Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponenthistone methyltransferase complex

PHF20 KMT2A BOD1L1 PRDM4 HCFC1

2.11e-0575935GO:0035097
GeneOntologyCellularComponentaxon

SLC12A6 CNTN4 RIN3 DRD2 SHANK2 CLCN3 MAP1B TRPC5 BRSK1 CBL SLC1A1 DICER1 DSCAML1 HCFC1

3.81e-058919314GO:0030424
GeneOntologyCellularComponentmethyltransferase complex

PHF20 KMT2A BOD1L1 PRDM4 HCFC1

1.21e-04108935GO:0034708
GeneOntologyCellularComponentdistal axon

DRD2 SHANK2 CLCN3 MAP1B TRPC5 BRSK1 CBL SLC1A1 DICER1

1.38e-04435939GO:0150034
GeneOntologyCellularComponentMLL1 complex

PHF20 KMT2A HCFC1

3.85e-0432933GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

PHF20 KMT2A HCFC1

4.22e-0433933GO:0044665
GeneOntologyCellularComponenthistone acetyltransferase complex

PHF20 SUPT7L KAT6A HCFC1

8.25e-0494934GO:0000123
GeneOntologyCellularComponentNSL complex

PHF20 HCFC1

1.05e-0311932GO:0044545
GeneOntologyCellularComponentprotein acetyltransferase complex

PHF20 SUPT7L KAT6A HCFC1

1.20e-03104934GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

PHF20 SUPT7L KAT6A HCFC1

1.43e-03109934GO:1902493
GeneOntologyCellularComponentcaveola

AKAP6 LIPE CBL VDR

1.53e-03111934GO:0005901
GeneOntologyCellularComponentpostsynapse

DRD2 SHANK2 CLCN3 MAP1B ARHGAP44 EIF4G1 PRICKLE2 NBEA DGCR8 SLC1A1 DICER1 CHRNB4

1.83e-0310189312GO:0098794
HumanPhenoAbnormal thought pattern

ZNF526 DRD2 CLCN3 IMPDH2 MAP1B KAT6A KMT2A DGCR8 HERC2 GTF2IRD1 RAD21

9.35e-064043011HP:5200269
HumanPhenoRestricted or repetitive behaviors or interests

ZNF526 DRD2 CLCN3 IMPDH2 MAP1B KAT6A KMT2A HERC2 GTF2IRD1 RAD21

2.78e-053683010HP:0031432
HumanPhenoPerseverative thought

ZNF526 DRD2 CLCN3 IMPDH2 MAP1B KAT6A KMT2A HERC2 GTF2IRD1 RAD21

3.43e-053773010HP:0030223
HumanPhenoDisordered formal thought process

ZNF526 DRD2 CLCN3 IMPDH2 MAP1B KAT6A KMT2A HERC2 GTF2IRD1 RAD21

4.21e-053863010HP:0025769
HumanPhenoBroad lateral eyebrow

KMT2A SON

1.00e-043302HP:0007933
MousePhenoreduced fertility

FREM2 DRD2 LIPE CLCN3 MAP1B TRPC5 KAT6A KMT2A AKAP13 SMARCAD1 HERC2 HSF2 ANKH ZFX VDR RAD21

1.14e-058447716MP:0001921
MousePhenoreduced female fertility

DRD2 TRPC5 KMT2A SMARCAD1 HERC2 HSF2 ANKH ZFX VDR

3.46e-05296779MP:0001923
MousePhenodecreased spleen weight

DRD2 SLC14A1 KAT6A EIF4G1 AKAP13 DICER1

3.63e-05113776MP:0004953
MousePhenoabnormal response to novelty

SLC12A6 DRD2 SHANK2 CLCN3 MAP1B ARHGAP44 EIF4G1 GTF2IRD1 SLC1A1 ATP10A DSCAML1 AREG SON VDR

8.75e-057877714MP:0003107
MousePhenoshort face

FREM2 KMT2A HCFC1

1.03e-0417773MP:0030066
MousePhenolethality during fetal growth through weaning, incomplete penetrance

AKAP6 FREM2 NRXN3 SHANK2 PHF20 MAP1B KMT2A SHISA2 SMARCAD1 HERC2 NEB HSF2 CBL DICER1 DSCAML1 HCFC1 ZFX

1.04e-0411247717MP:0011112
MousePhenoabnormal seizure response to pharmacological agent

SLC12A6 DRD2 CLCN3 TRPC5 PRICKLE2 CHRNB4

1.57e-04147776MP:0000950
DomainDS_RBD

DGCR8 DICER1 SON

1.31e-0421893PS50137
Domain-

DGCR8 DICER1 SON

2.82e-04278933.30.160.20
DomainAT_hook

PHF20 KMT2A BOD1L1

2.82e-0427893SM00384
DomainAT_hook_DNA-bd_motif

PHF20 KMT2A BOD1L1

2.82e-0427893IPR017956
DomaindsRBD_dom

DGCR8 DICER1 SON

3.14e-0428893IPR014720
DomainENTH_VHS

U2SURP RPRD2 EPN2

3.49e-0429893IPR008942
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

PHF20 KMT2A BOD1L1 HCFC1

4.76e-0538754MM17073
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

PHF20 KMT2A BOD1L1 HCFC1

7.10e-0542754M48018
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC4 MUC20

7.71e-0516753M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC4 MUC20

9.32e-0517753M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC4 MUC20

1.80e-0421753MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC4 MUC20

2.37e-0423753M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 MUC4 MUC20

3.44e-0426753M27483
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

DGCR8 DICER1

4.13e-046752M39578
PathwayWP_MIRNA_BIOGENESIS

DGCR8 DICER1

4.13e-046752M39416
Pubmed

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

MUC16 MUC4 MUC20

1.85e-08393330236127
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IMPDH2 MAP1B U2SURP EIF4G1 MKI67 BYSL KMT2A HERC2 DICER1 HCFC1 PPP6R3 SON RAD21

2.10e-08653931322586326
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FREM2 ARHGEF28 CLCN3 RPAP1 IMPDH2 MAP1B KMT2A AKAP13 SMARCAD1 DICER1 HCFC1 RBM20

1.72e-07650931238777146
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

MRPS31 SHANK2 IMPDH2 PIEZO1 SUPT7L EIF4G1 BYSL KMT2A ZNF217 DGCR8 ITPRID2 HERC2 DICER1 EPN2 PPP6R3 SON RAD21

4.23e-071497931731527615
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

TOX4 IMPDH2 MAP1B KAT6A EIF4G1 MKI67 BYSL DGCR8 HERC2 HSF2 SON RAD21

8.87e-07759931235915203
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TOX4 IMPDH2 MAP1B U2SURP MKI67 KMT2A RPRD2 AASDHPPT BOD1L1 HCFC1 PPP6R3 SON RAD21

1.24e-06934931333916271
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

TOX4 MAP1B U2SURP EIF4G1 MKI67 BYSL KMT2A RPRD2 BOD1L1 DGCR8 HCFC1 SON RAD21

1.57e-06954931336373674
Pubmed

Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.

PHF20 KMT2A HCFC1

2.19e-061093324244196
Pubmed

Human transcription factor protein interaction networks.

MRPS31 IMPDH2 SUPT7L EIF4G1 MKI67 KMT2A RPRD2 ZNF217 HERC2 CABIN1 HCFC1 RBM20 ZNF691 PPP6R3 RAD21

5.73e-061429931535140242
Pubmed

MicroRNA activity is suppressed in mouse oocytes.

DGCR8 DICER1

7.07e-06293220116252
Pubmed

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.

NEB RBM20

7.07e-06293227139341
Pubmed

MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

DGCR8 DICER1

7.07e-06293228104803
Pubmed

Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.

DRD2 DGCR8

7.07e-06293224904170
Pubmed

Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.

DGCR8 DICER1

7.07e-06293238252873
Pubmed

Skeletal stem and progenitor cells maintain cranial suture patency and prevent craniosynostosis.

AXIN2 TWIST1

7.07e-06293234330896
Pubmed

Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.

MUC16 MUC4

7.07e-06293223544943
Pubmed

Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.

DGCR8 DICER1

7.07e-06293225244517
Pubmed

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.

DGCR8 DICER1

7.07e-06293221712401
Pubmed

CBL mutations in infant acute lymphoblastic leukaemia.

KMT2A CBL

7.07e-06293221988239
Pubmed

DGCR8-dependent microRNA biogenesis is essential for skin development.

DGCR8 DICER1

7.07e-06293219114655
Pubmed

Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.

KMT2A CBL

7.07e-06293212696071
Pubmed

Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.

DGCR8 DICER1

7.07e-06293225934699
Pubmed

Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation.

CBL TWIST1

7.07e-06293217003487
Pubmed

A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes.

DGCR8 DICER1

7.07e-06293224209619
Pubmed

Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling.

MUC4 MUC20

7.07e-06293226673820
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RPAP1 EIF4G1 MKI67 KMT2A ZNF217 SMARCAD1 ITPRID2 GTF2IRD1 ZFX PPP6R3 SON

7.19e-06774931115302935
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RIN3 SHANK2 RPAP1 PIEZO1 ARHGAP44 KAT6A EIF4G1 AKAP13 HERC2 GTF2IRD1 CABIN1 FAAP100 HCFC1

7.74e-061105931335748872
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

AKAP6 U2SURP PPIP5K1 HERC2 CABIN1

9.15e-061049359205841
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

TOX4 PHF20 KCTD10 U2SURP EIF4G1 MKI67 C11orf24 HERC2 HSF2 FAAP100 HCFC1 PRRC1 RAD21

1.24e-051155931320360068
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC16 MUC4 MUC20

1.47e-051893318834073
Pubmed

VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.

MKI67 PRICKLE2 AXIN2

1.47e-051893331068622
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

IMPDH2 EIF4G1 AKAP13 ITPRID2 HERC2 DICER1

1.78e-0520293633005030
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

TOX4 MKI67 KMT2A ZNF217 GTF2IRD1 CBL PRDM4 ZFX TWIST1 VDR

2.05e-05709931022988430
Pubmed

Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis.

AXIN2 TWIST1

2.12e-05393220547147
Pubmed

Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model.

MUC16 MUC4

2.12e-05393223053434
Pubmed

Predicting Lymph Node Metastasis in Endometrial Cancer Using Serum CA125 Combined with Immunohistochemical Markers PR and Ki67, and a Comparison with Other Prediction Models.

MKI67 MUC16

2.12e-05393227163153
Pubmed

A microRNA expression signature of osteoclastogenesis.

DGCR8 DICER1

2.12e-05393221273303
Pubmed

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.

KMT2A SON

2.12e-05393226990989
Pubmed

E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases.

KMT2A HCFC1

2.12e-05393219763085
Pubmed

Overexpression of TrpC5 promotes tumor metastasis via the HIF-1α-Twist signaling pathway in colon cancer.

TRPC5 TWIST1

2.12e-05393228864720
Pubmed

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.

MUC16 MUC20

2.12e-05393226770020
Pubmed

Pineoblastoma is uniquely tolerant of mutually exclusive loss of DICER1, DROSHA or DGCR8.

DGCR8 DICER1

2.12e-05393232124011
Pubmed

Drosha, DGCR8, and Dicer mRNAs are down-regulated in human cells infected with dengue virus 4, and play a role in viral pathogenesis.

DGCR8 DICER1

2.12e-05393227173348
Pubmed

EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate.

CBL AREG

2.12e-05393218045238
Pubmed

Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models.

CNTN4 SHANK2

2.12e-05393229970989
Pubmed

Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells.

DGCR8 DICER1

2.12e-05393222925886
Pubmed

Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.

DICER1 ALOX12

2.12e-05393215576842
Pubmed

Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma.

MKI67 VDR

2.12e-05393222542077
Pubmed

Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease.

DGCR8 DICER1

2.12e-05393223663110
Pubmed

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).

MUC16 MUC4

2.12e-05393227483328
Pubmed

MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer.

MUC16 MUC4

2.12e-05393224204560
Pubmed

The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.

KMT2A HCFC1

2.12e-05393217578910
Pubmed

Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.

MUC16 MUC4

2.12e-05393224939955
Pubmed

Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.

DGCR8 DICER1

2.12e-05393225439752
Pubmed

The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.

DGCR8 DICER1

2.12e-05393230295958
Pubmed

Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.

PMEL CABIN1

2.12e-05393234503492
Pubmed

Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone.

MUC16 MUC4

2.12e-05393217592322
Pubmed

A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus.

MUC4 MUC20

2.12e-05393235065708
Pubmed

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

NEB RBM20

2.12e-05393227889803
Pubmed

MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells.

KAT6A MKI67

2.12e-05393224307508
Pubmed

Biogenesis of mammalian microRNAs by a non-canonical processing pathway.

DGCR8 DICER1

2.12e-05393222270084
Pubmed

Recurrent YAP1 and KMT2A Gene Rearrangements in a Subset of MUC4-negative Sclerosing Epithelioid Fibrosarcoma.

KMT2A MUC4

2.12e-05393231592798
Pubmed

Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2.

KMT2A HSF2

2.12e-05393226478434
Pubmed

Craniosynostosis of coronal suture in twist1 mice occurs through endochondral ossification recapitulating the physiological closure of posterior frontal suture.

AXIN2 TWIST1

2.12e-05393221811467
Pubmed

Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters.

DRD2 KMT2A

2.12e-05393217942719
Pubmed

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

MUC16 MUC4

2.12e-05393235879412
Pubmed

Transcript Level of MicroRNA Processing Elements in Gastric Cancer.

DGCR8 DICER1

2.12e-05393230168106
Pubmed

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice.

PIEZO1 TWIST1

2.12e-05393237917195
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

MAP1B U2SURP MKI67 RPRD2 SON

2.70e-0513093535545047
Pubmed

Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis.

MKI67 DICER1 AXIN2

2.75e-052293325651362
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2A BOD1L1 HCFC1

2.75e-052293326886794
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MRPS31 FREM2 RPAP1 PRICKLE2 C11orf24 AKAP13 NBEA BOD1L1 DSCAML1 CHRNB4

2.82e-05736931029676528
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

IMPDH2 RPRD2 BOD1L1 DGCR8 SAGE1 GTF2IRD1 CABIN1 FAAP100

3.02e-0545393829656893
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

MRPS31 BYSL AASDHPPT CBL DICER1 PPP6R3

3.11e-0522393633187986
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

U2SURP SUPT7L KMT2A RPRD2 HCFC1

3.12e-0513493525452129
Pubmed

Tagging genes with cassette-exchange sites.

KCTD10 EIF4G1 MKI67 AKAP13 SMARCAD1 DGCR8 PPP6R3

3.37e-0533593715741177
Pubmed

Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria.

MKI67 AXIN2 TWIST1

3.60e-052493329852132
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

KAT6A MKI67 KMT2A BOD1L1 SMARCAD1 HERC2 CABIN1 HCFC1 RAD21

3.75e-0560893936089195
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

TOX4 PHF20 U2SURP SUPT7L MKI67 KMT2A RPRD2 GTF2IRD1 CABIN1 HCFC1 ZFX SON RAD21

4.04e-051294931330804502
Pubmed

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

EIF4G1 KMT2A HERC2 RAD21

4.06e-057193429346117
Pubmed

MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.

MKI67 DGCR8 DICER1

4.08e-052593326062936
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SLC12A6 SHANK2 PDE9A MAP1B ARHGAP44 KAT6A RASGEF1C AKAP13 RPRD2 BOD1L1 GTF2IRD1 SLC1A1 ATP10A ANKH

4.09e-051489931428611215
Pubmed

Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.

DRD2 TRPC5

4.23e-05493218261457
Pubmed

Immunohistochemical analysis of 1,25-dihydroxyvitamin-D3-receptors, estrogen and progesterone receptors and Ki-67 in ovarian carcinoma.

MKI67 VDR

4.23e-05493212174912
Pubmed

DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.

MKI67 PMEL

4.23e-05493228334846
Pubmed

The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.

C11orf24 PPP6R3

4.23e-05493211401438
Pubmed

MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development.

MKI67 DICER1

4.23e-05493221969379
Pubmed

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.

DGCR8 DICER1

4.23e-05493226748703
Pubmed

Distinct requirements of microRNAs in NK cell activation, survival, and function.

DGCR8 DICER1

4.23e-05493220805417
Pubmed

TRPV4 activation in human corneal epithelial cells promotes membrane mucin production.

MUC16 MUC4

4.23e-05493239024979
Pubmed

Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles.

MKI67 DICER1

4.23e-05493234572101
Pubmed

Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells.

KAT6A KMT2A

4.23e-05493223994619
Pubmed

Recognition of unknown conserved alternatively spliced exons.

PPIP5K1 SON

4.23e-05493216110330
Pubmed

TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.

RIN3 KCTD10

4.23e-05493222810651
Pubmed

Distinct roles of microRNAs in epithelium and mesenchyme during tooth development.

MKI67 DICER1 AXIN2

4.60e-052693322753148
Pubmed

A protein interaction landscape of breast cancer.

TOX4 IMPDH2 MKI67 RO60 SMARCAD1 ITPRID2 AREG PPP6R3 RAD21

5.18e-0563493934591612
Pubmed

Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients.

SHISA2 AXIN2 TWIST1

5.78e-052893325082703
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

EIF4G1 MKI67 AKAP13 RPRD2 CBL HCFC1 PPP6R3 SON

6.29e-0550393816964243
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

MRPS31 IMPDH2 U2SURP MKI67 BYSL BOD1L1 ZNF217 DGCR8 HCFC1 SON RAD21

6.77e-05989931136424410
Pubmed

Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states.

PIEZO1 MKI67

7.04e-05593235302846
InteractionARRDC2 interactions

MAP1B BOD1L1 HCFC1 EPN2 PPP6R3

4.46e-0654915int:ARRDC2
Cytoband11q23

DRD2 KMT2A DSCAML1

5.47e-053693311q23
Cytoband15q13

SLC12A6 HERC2

1.45e-04993215q13
GeneFamilyCD molecules|Mucins

MUC16 MUC22 MUC4 MUC20

5.48e-0721584648
GeneFamilyZinc fingers MYND-type|A-kinase anchoring proteins

AKAP6 AKAP13 NBEA

1.08e-0429583396
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MAP1B TRPC5 MKI67 HCFC1 VDR

2.84e-04181585694
GeneFamilyPHD finger proteins

PHF20 KAT6A KMT2A

3.02e-039058388
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRXN3 SHANK2 MUC16 NBEA MUC4 MUC20

1.13e-061619362d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

NRXN3 ARHGEF28 SHANK2 MUC16 NBEA MUC4

2.37e-06183936940cbe298e9c53b5622af09264586ed823d3141f
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK2 PDE9A PIEZO1 RASGEF1C MUC4 MUC20

2.86e-0618993627e5d706f10a6221f314faf642eede15deab3165
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

NRXN3 ARHGEF28 SHANK2 MUC16 NBEA MUC4

2.94e-0619093651ca9ef4df3220487152fcf684147730637c7cc1
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 MUC16 NBEA MUC4 NEK11 CDHR4

3.32e-061949364a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B KMT2A NBEA BOD1L1 SON VDR

3.42e-061959363e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B KMT2A NBEA BOD1L1 SON VDR

3.42e-061959367796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.52e-06196936676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.73e-06198936c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.73e-061989366d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.73e-061989364ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.73e-061989360ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CNTN4 NRXN3 SHANK2 MAP1B ARHGAP44 NBEA

3.96e-0620093648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KMT2A AKAP13 BOD1L1 AREG SON RAD21

3.96e-062009367dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIPE NRXN3 ARHGEF28 SHANK2 ARHGAP44

8.83e-061339355bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPIP5K1 NBEA AASDHPPT HSF2 CHRNB4

2.43e-05164935d8ecb3de6e34f5f574449e3d2f26fa0b2b7e84e8
ToppCellControl|World / group, cell type (main and fine annotations)

CNTN4 FREM2 NRXN3 ARHGEF28 SHANK2

2.73e-05168935a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellfacs-Lung-EPCAM-3m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF28 NEB SLC1A1 ATP10A VDR

2.88e-0517093582ccba6ec53f6ca0d19949a1277434c565af2983
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF28 NEB SLC1A1 ATP10A VDR

2.88e-05170935ab19ea729ed8c8361c870e79893d1a95a1e487fa
ToppCell3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN3 CLCN3 PDE9A AKAP13 ITPRID2

2.97e-051719350de81d12a8000f2c59cdb214e67dc526d18098fe
ToppCell3'-Adult-Distal_Rectal-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN3 CLCN3 PDE9A AKAP13 ITPRID2

2.97e-051719350597339618fb4d416d55c538eceb353218a55002
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

MAP1B MUC16 NBEA NEK11 CDHR4

3.05e-05172935187ae91148d293537afc77e10da2b64302322224
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGEF1C PPIP5K1 SHISA2 ZNF691 VDR

3.22e-051749356987fe7959afce347282f632abc16d800ccab7c4
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ARHGEF28 SHANK2 DSCAML1 ZFX ZNF710

3.40e-051769351e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTN4 FREM2 SHANK2 ARHGAP44 SLC1A1

3.69e-05179935cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DRD2 MAP1B NBEA ITPRID2 ADGRG4

3.69e-051799358ce5000088b727783a0619baa16a2cd036d21f54
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 ARHGEF28 SHANK2 SLC1A1 DSCAML1

3.79e-05180935358923e4228035a3e90e2957392089219e90dcd7
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 ARHGEF28 SHANK2 SLC1A1 DSCAML1

3.79e-05180935864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRXN3 SHANK2 MUC16 NBEA MUC4

3.99e-051829353f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 ARHGEF28 SHANK2 SLC1A1 DSCAML1

4.10e-051839356878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM2 NRXN3 ARHGEF28 SHANK2 ARHGAP44

4.32e-051859350d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CNTN4 NRXN3 SHANK2 ARHGAP44 MUC4

4.32e-05185935cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP6 SHANK2 MAP1B NEK11 CDHR4

4.32e-051859355e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 NRXN3 MAP1B ATP10A RBM20

4.54e-05187935ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTN4 SHANK2 ARHGAP44 GTF2IRD1 SLC1A1

4.54e-05187935d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 NRXN3 MAP1B ATP10A RBM20

4.54e-05187935530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SHANK2 ARHGAP44 GTF2IRD1 MUC4 AREG

4.66e-0518893543a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

CNTN4 ARHGEF28 SHANK2 NBEA MUC4

4.78e-0518993584d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

AKAP6 AKAP13 GTF2IRD1 ANKH RBM20

4.90e-0519093593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 NRXN3 ARHGEF28 SHANK2 AREG

4.90e-05190935625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GARIN4 ARHGAP44 SHISA2 ITPRID2 VDR

5.02e-05191935ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

CNTN4 FREM2 SHANK2 ARHGAP44 SLC1A1

5.02e-05191935d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 NRXN3 ARHGEF28 SHANK2 AREG

5.15e-0519293525378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellASK452-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CLCN3 PHF20 AKAP13 AREG RAD21

5.15e-051929358269b88ff6073a908f547fcc7c5941f2e8289694
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 NRXN3 MAP1B ATP10A RBM20

5.15e-0519293524e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

PIEZO1 MKI67 KMT2A BOD1L1 SON

5.15e-051929359cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 SHANK2 ARHGAP44 AKAP13 SLC1A1

5.15e-0519293529f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 NRXN3 ARHGEF28 SHANK2 AREG

5.15e-05192935d3634574b2e8d2ded6446969361b70761b331aea
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 NRXN3 ARHGEF28 SHANK2 AREG

5.15e-051929351aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

CNTN4 NRXN3 SHANK2 NBEA MUC4

5.28e-051939352bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCN3 PDE9A RASGEF1C MUC4 MUC20

5.28e-051939351526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A RASGEF1C MUC4 MUC20 VDR

5.41e-051949350ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCN3 PDE9A SLC1A1 MUC4 MUC20

5.41e-05194935550e61a40be2baa59520aaf5912bb99ad094ba15
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

RPAP1 PIEZO1 ITPRID2 ATP10A EPN2

5.41e-0519493588db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

RPAP1 PIEZO1 ITPRID2 ATP10A EPN2

5.41e-05194935a71728202493d4858342ea2756ea281cd0d99a3a
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SHANK2 PRICKLE2 SLC1A1 MUC4 CDHR4

5.54e-0519593521dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRPS31 MUC16 NBEA NEK11 CDHR4

5.54e-051959359651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCellfacs-Skin-nan-18m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GARIN4 SLC14A1 ARHGAP44 SHISA2 ANKH

5.68e-0519693581f9754567bbfa67edd304b9ef7b03e7bd9a3b52
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRPS31 MUC16 NBEA AXIN2 TWIST1

5.68e-05196935d9426eba69047166ffa8179f1654e011c1020328
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SHANK2 MKI67 PRICKLE2 MUC4 CDHR4

5.68e-05196935af4cdc61830685a888a1209826c23bcf54a43084
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MRPS31 MUC16 NBEA AXIN2 TWIST1

5.68e-051969357e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SHANK2 MKI67 PRICKLE2 MUC4 CDHR4

5.68e-051969356d02d494196e3f857d53eea46d9419690d43beca
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FREM2 ARHGEF28 SHANK2 PDE9A GTF2IRD1

5.68e-05196935eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A PIEZO1 RASGEF1C MUC4 MUC20

5.82e-05197935ed3a37f532741764060d297a560eeeeec279d9c4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRPC5 ICAM3 SIGLEC5 AREG VDR

5.82e-05197935ad4147435ac0fdf6274fea6d535f4e00d990e535
ToppCellBL-critical-LOC-Epithelial|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGEF28 MUC16 NBEA MUC4 MUC20

5.96e-051989356218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGEF28 MUC16 NBEA MUC4 MUC20

5.96e-05198935a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NRXN3 SHANK2 MUC16 NBEA MUC4

5.96e-05198935fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NRXN3 ARHGEF28 MUC16 NBEA MUC4

6.25e-05200935b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCellBAL-Control-cDC_7|Control / Compartment, Disease Groups and Clusters

SUPT7L SLC9B2 ATP10A AREG

1.21e-04121934b49b044a687a31883dfccecf10a183b5ba567f7a
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRXN3 SHANK2 ARHGAP44 AKAP13

1.46e-041279345b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell(06)_Krt4/13+-(4)_1wkpi|(06)_Krt4/13+ / shred by cell type and Timepoint

SLC1A1 MUC20

1.88e-0410932c76279ff80347dfffb7d7074b37085e53d047509
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_2|E16.5-samps / Age Group, Lineage, Cell class and subclass

ZNF526 SLC14A1 PMEL BRSK1

2.00e-0413893405de2cef97c0912fb23f138dd45348f565a14d74
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

CNTN4 TRPC5 RASGEF1C DSCAML1

2.68e-041499346e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF28 PIEZO1 ATP10A MUC20

2.89e-041529347a1072315cce71eefe2d32149a107d5648999968
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-B|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MKI67 SIGLEC5 ATP10A NEK11

2.89e-041529345ce8920aedd39a4daf7082153b5e213707c14227
ToppCellPBMC-Control-cDC_2|Control / Compartment, Disease Groups and Clusters

NRXN3 SHANK2 MUC16 BRSK1

2.97e-041539344ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCellSevere-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MAP1B SHISA2 NEK11 AXIN2

2.97e-0415393444572f87d403e314050ab935d2cd676c33d9c287
ToppCellRV-16._Neuronal|RV / Chamber and Cluster_Paper

NRXN3 PDE9A MAP1B RASGEF1C

2.97e-04153934bed8bbf5c5cbfbf46a816066da472c3fdddecb5d
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF28 PIEZO1 ATP10A MUC20

3.04e-041549346c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCellSevere-B_naive-5|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MAP1B SHISA2 NEK11 AXIN2

3.27e-04157934a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP44 EIF4G1 GTF2IRD1 AXIN2

3.52e-0416093419105debef96ea0c267d6a1d332303ec668ae47e
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

MAP1B BRSK1 HCFC1 RBM20

3.60e-0416193464891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SLC14A1 RASGEF1C AREG

3.77e-04163934360cd65decda24853124f33a174f5224d7f3ce23
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SLC14A1 RASGEF1C AREG

3.77e-04163934b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 MAP1B ATP10A TWIST1

3.95e-041659344f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN4 MAP1B ATP10A TWIST1

3.95e-04165934cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 ZNF526 KAT6A FAAP100

4.04e-04166934b64ab3d13b76bba3c305ebbfc96f983cd6ca30c9
ToppCellfacs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RIN3 SLC14A1 SIGLEC5 ANKH

4.13e-04167934fd84a99ea142d1684cdcf4a88ef1d541760bc78a
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTN4 ARHGEF28 SHANK2 DSCAML1

4.23e-04168934a086c306be430adf0632ba53e98cd8014d2de330
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-MEMP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

IMPDH2 ALOX12 NEK11 MUC20

4.32e-041699349a2fedee8ff90513bc2cbe2a65d07575ee8a0b70
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 NBEA NEK11 CDHR4

4.32e-0416993414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTN4 SHANK2 PRICKLE2 RSPH6A

4.42e-04170934a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC14A1 PPIP5K1 ATP10A NEK11

4.42e-04170934c1f7f1bb8865e954bb499963d82bb51923d5d8d6
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FREM2 MUC16 MUC4 MUC20

4.52e-0417193425c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FREM2 MUC16 MUC4 MUC20

4.52e-04171934fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCellfacs-GAT-Fat-24m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A MUC4 CHRNB4 VDR

4.72e-04173934815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCellfacs-GAT-Fat-24m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A MUC4 CHRNB4 VDR

4.72e-0417393498e464d9e6d6b69421e9e4041b638b6825247f60
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRXN3 MUC16 NBEA MUC4

4.72e-04173934464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCellfacs-GAT-Fat-24m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A MUC4 CHRNB4 VDR

4.72e-041739343e6f0a08eddfd61871f7a85acccf6d539af6ebda
Drug0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A

LIPE CLCN3 MAP1B TRPC5 KAT6A DGCR8 ANKH DICER1

1.47e-061999284334_UP
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

ARHGEF28 MKI67 GTF2IRD1 DICER1 HCFC1 ZFX RAD21

6.84e-061749275940_DN
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA

PHF20 EIF4G1 KMT2A AKAP13 RO60 DICER1 SON

7.66e-06177927985_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

EIF4G1 KMT2A AKAP13 RO60 DICER1 SON RAD21

7.94e-061789273998_DN
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A

TOX4 EIF4G1 KMT2A RO60 DICER1 SON RAD21

1.13e-051889276735_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

CLCN3 MAP1B KAT6A AKAP13 NEB CBL DICER1

1.26e-051919274279_DN
DrugIsocorydine (+) [475-67-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

RIN3 KMT2A DGCR8 NEB CBL ZFX ZNF710

1.49e-051969272780_DN
DrugTrihexyphenidyl-D,L Hydrochloride [58947-95-8]; Down 200; 11.8uM; HL60; HT_HG-U133A

DRD2 POM121L2 RO60 DGCR8 GTF2IRD1 EPN2 VDR

1.49e-051969272158_DN
DrugHomosalate [118-56-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A

SLC12A6 RIN3 PHF20 RPAP1 KAT6A HCFC1 VDR

1.54e-051979274355_DN
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

DRD2 NBEA NEB GTF2IRD1 HCFC1 ALOX12 EPN2

1.54e-051979272702_DN
DrugChlorhexidine [55-56-1]; Down 200; 8uM; PC3; HT_HG-U133A

SLC12A6 SHANK2 U2SURP C11orf24 AKAP13 FAAP100 ZNF710

1.59e-051989276302_DN
DrugCP-319743 [172078-87-4]; Down 200; 10uM; MCF7; HT_HG-U133A

PDE9A U2SURP RO60 HSF2 NEK11 ZFX ZNF710

1.59e-051989277532_DN
DrugTerazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A

DRD2 MAP1B KMT2A NEB CABIN1 ZNF710 VDR

1.64e-051999276092_DN
DrugBetaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; HL60; HG-U133A

ICAM3 KMT2A AKAP13 RPRD2 DGCR8 CABIN1 ZNF710

1.69e-052009271592_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SLC14A1 U2SURP RPRD2 GTF2IRD1 HCFC1 ZFX

5.27e-051639267285_DN
DrugHC toxin from Helminthosporium carbonum; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

RO60 DGCR8 GTF2IRD1 HCFC1 ZFX ZNF710

7.57e-05174926909_DN
DrugCaptopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

EIF4G1 KMT2A RO60 DICER1 SON RAD21

8.85e-051799264585_DN
Drugsulfolene

TWIST1 VDR

9.64e-054922CID000006498
DrugAdamantamine fumarate [80789-67-9]; Down 200; 9.6uM; HL60; HT_HG-U133A

TOX4 CLCN3 HSF2 DICER1 PRRC1 RAD21

1.03e-041849261344_DN
DrugLabetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A

DRD2 PHF20 RO60 DGCR8 NEB VDR

1.30e-041929266809_DN
Druggeldanamycin

MAP1B KAT6A KMT2A BOD1L1 RO60 ITPRID2 CBL ZFX

1.30e-04371928ctd:C001277
DrugMefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A

U2SURP SUPT7L C11orf24 AKAP13 ITPRID2 DICER1

1.34e-041939266205_DN
DrugDibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

RIN3 DRD2 KAT6A RO60 HCFC1 VDR

1.38e-041949264149_DN
DrugSTOCK1N-35215; Down 200; 10uM; PC3; HT_HG-U133A

TOX4 TRPC5 DGCR8 ATP10A HCFC1 ALOX12

1.38e-041949266380_DN
DrugNaftifine hydrochloride [65473-14-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A

DRD2 MAP1B TRPC5 KAT6A NEB ZNF710

1.38e-041949267032_UP
DrugICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A

RPAP1 PIEZO1 C11orf24 CABIN1 HCFC1 ZFX

1.38e-041949261179_DN
DrugBupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A

U2SURP C11orf24 HSF2 HCFC1 EPN2 VDR

1.41e-041959267435_UP
DrugNaloxone hydrochloride [357-08-4]; Down 200; 11uM; HL60; HG-U133A

KMT2A C11orf24 ZNF217 DGCR8 ATP10A SON

1.41e-041959262006_DN
DrugGentamicine sulfate [1405-41-0]; Down 200; 2.6uM; MCF7; HT_HG-U133A

ARHGEF28 TRPC5 KAT6A POM121L2 ALOX12 VDR

1.41e-041959262245_DN
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

RIN3 RPAP1 U2SURP BYSL DGCR8 VDR

1.41e-041959261207_DN
DrugCisapride [81098-60-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A

U2SURP AASDHPPT RO60 HSF2 ZFX EPN2

1.41e-041959265305_DN
DrugNabumetone [42924-53-8]; Down 200; 17.6uM; HL60; HT_HG-U133A

RIN3 PHF20 RPAP1 RO60 ZFX ZNF710

1.41e-041959263108_DN
DrugMethyldopa (L,-) [555-30-6]; Up 200; 19uM; HL60; HG-U133A

ICAM3 CBL ATP10A PRRC1 ZFX ZNF710

1.41e-041959261619_UP
DrugAzathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A

DRD2 PHF20 KAT6A AKAP13 FAAP100 EPN2

1.41e-041959264106_DN
DrugPiretanide [55837-27-9]; Down 200; 11uM; MCF7; HT_HG-U133A

PHF20 RPAP1 MAP1B SUPT7L DGCR8 VDR

1.41e-041959266828_DN
DrugNovobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A

SLC12A6 RPAP1 RO60 HSF2 NEK11 ZFX

1.45e-041969264392_DN
DrugEpivincamine [6835-99-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A

CLCN3 PHF20 MAP1B KMT2A AKAP13 HCFC1

1.45e-041969262775_DN
DrugProstaglandin E1; Down 200; 10uM; PC3; HT_HG-U133A

RIN3 DRD2 SHANK2 MAP1B AKAP13 DGCR8

1.45e-041969266571_DN
DrugNapelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A

RIN3 POM121L2 ATP10A ANKH DICER1 ZNF710

1.45e-041969266824_UP
DrugCefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A

RPAP1 AKAP13 RPRD2 PMEL EPN2 VDR

1.45e-041969264718_DN
DrugTrimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; HL60; HT_HG-U133A

AKAP13 RO60 DGCR8 GTF2IRD1 HCFC1 ZNF710

1.45e-041969262736_DN
DrugBuspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A

MAP1B RO60 PMEL NEB HCFC1 ZNF710

1.45e-041969265343_UP
DrugKhellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A

PHF20 KAT6A NEB DICER1 ZFX ZNF710

1.45e-041969264987_DN
DrugTalampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A

POM121L2 AKAP13 CABIN1 CBL HCFC1 ZNF710

1.50e-041979267014_UP
DrugFlecainide acetate [54143-56-5]; Down 200; 8.4uM; PC3; HT_HG-U133A

RIN3 DRD2 POM121L2 NEB FAAP100 HCFC1

1.50e-041979264318_DN
DrugFolinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; PC3; HT_HG-U133A

RIN3 NEB FAAP100 ATP10A HCFC1 NEK11

1.50e-041979267401_UP
DrugSolasodine [126-17-0]; Up 200; 9.6uM; PC3; HT_HG-U133A

LIPE NRXN3 SHANK2 SIGLEC5 ALOX12 VDR

1.50e-041979264305_UP
DrugGlimepiride [93479-97-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A

AKAP6 PHF20 MAP1B SUPT7L CABIN1 HCFC1

1.50e-041979262809_UP
DrugHarmol hydrochloride monohydrate [40580-83-4]; Up 200; 15.8uM; HL60; HG-U133A

U2SURP DGCR8 HSF2 CBL ATP10A EPN2

1.50e-041979261750_UP
DrugBumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A

MAP1B KAT6A AKAP13 CABIN1 FAAP100 ZNF710

1.50e-041979267440_DN
DrugFinasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

DRD2 NRXN3 POM121L2 PMEL CBL ATP10A

1.50e-041979264766_UP
DrugAlfadolone acetate [23930-37-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

NRXN3 MAP1B SLC14A1 AKAP13 DGCR8 CABIN1

1.50e-041979267262_UP
DrugStreptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A

DRD2 AKAP13 RO60 CABIN1 HCFC1 NEK11

1.50e-041979267194_DN
DrugNorgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A

RPAP1 KMT2A AKAP13 RO60 HCFC1 EPN2

1.50e-041979263406_DN
DrugOxyphenbutazone [129-20-4]; Down 200; 12.4uM; PC3; HT_HG-U133A

DRD2 U2SURP ARHGAP44 AKAP13 NEB NEK11

1.50e-041979264506_DN
DrugNicardipine hydrochloride [54527-84-3]; Up 200; 7.8uM; MCF7; HT_HG-U133A

DRD2 PDE9A SLC14A1 NEB ANKH ALOX12

1.54e-041989263215_UP
DrugAG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A

NRXN3 ARHGEF28 SUPT7L KAT6A HSF2 ZFX

1.54e-041989266557_DN
Drugprostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

DRD2 MAP1B NEB ATP10A NEK11 EPN2

1.54e-041989266590_UP
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; MCF7; HT_HG-U133A

SHANK2 RPRD2 CBL NEK11 ZNF710 VDR

1.54e-041989266790_DN
DrugPinacidil [85371-64-8]; Up 200; 16.4uM; MCF7; HT_HG-U133A

PHF20 POM121L2 CBL ATP10A NEK11 ZFX

1.54e-041989267437_UP
Drug(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; PC3; HT_HG-U133A

DRD2 AKAP13 CABIN1 CBL HCFC1 ZNF710

1.54e-041989267296_UP
DrugFipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; HL60; HG-U133A

RPRD2 CABIN1 PRDM4 ATP10A DICER1 RAD21

1.54e-041989261560_DN
DrugNalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

DRD2 CLCN3 C11orf24 DGCR8 PRDM4 HCFC1

1.54e-041989267177_DN
Drug2-propylpentanoic acid; Down 200; 500uM; PC3; HT_HG-U133A

DRD2 PHF20 KAT6A AKAP13 NEB ANKH

1.54e-041989264464_DN
DrugDacarbazine [4342-03-4]; Up 200; 22uM; HL60; HG-U133A

AKAP6 RPAP1 DGCR8 PRDM4 FAAP100 ZNF710

1.54e-041989261762_UP
DrugDantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; PC3; HT_HG-U133A

AKAP6 MAP1B KAT6A DGCR8 ATP10A ANKH

1.54e-041989264343_UP
DrugDichlorphenamide [120-97-8]; Down 200; 13.2uM; MCF7; HT_HG-U133A

C11orf24 AKAP13 NEB HSF2 HCFC1 EPN2

1.54e-041989265286_DN
DrugPHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A

SHANK2 RO60 CBL ANKH HCFC1 VDR

1.54e-041989263854_DN
DrugDantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; HL60; HT_HG-U133A

RIN3 SIGLEC5 RSPH6A DGCR8 ALOX12 ZNF710

1.54e-041989262369_UP
DrugFlavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; PC3; HT_HG-U133A

RIN3 NRXN3 POM121L2 CABIN1 ATP10A NEK11

1.54e-041989266326_UP
DrugProxyphylline [603-00-9]; Down 200; 16.8uM; HL60; HT_HG-U133A

KMT2A POM121L2 NEB FAAP100 ZFX ZNF710

1.58e-041999263115_DN
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A_EA

PHF20 TRPC5 AKAP13 RO60 DGCR8 CABIN1

1.58e-041999261009_UP
DrugPipenzolate bromide [125-51-9]; Down 200; 9.2uM; PC3; HT_HG-U133A

SLC14A1 DGCR8 CABIN1 FAAP100 NEK11 ZNF710

1.58e-041999264484_DN
DrugChrysin [480-40-0]; Up 200; 15.8uM; MCF7; HT_HG-U133A

SLC12A6 DRD2 SHANK2 PMEL CABIN1 NEK11

1.58e-041999265505_UP
DrugYohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; HL60; HT_HG-U133A

DRD2 POM121L2 RO60 NEB FAAP100 EPN2

1.58e-041999262147_DN
DrugClebopride maleate [84370-95-6]; Up 200; 8.2uM; MCF7; HT_HG-U133A

SHANK2 PMEL HCFC1 ZFX ZNF710 VDR

1.58e-041999265412_UP
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; MCF7; HT_HG-U133A

AKAP6 RIN3 SLC14A1 POM121L2 DGCR8 ATP10A

1.58e-041999262297_UP
DrugEpiandrosterone [481-29-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A

DRD2 SHANK2 TRPC5 KAT6A HCFC1 ALOX12

1.58e-041999263306_UP
DrugDeferoxamine mesylate [138-14-7]; Up 200; 6uM; PC3; HT_HG-U133A

AKAP6 DRD2 SHANK2 SLC14A1 ARHGAP44 ANKH

1.62e-042009263760_UP
DrugAminophylline [317-34-0]; Down 200; 9.6uM; HL60; HT_HG-U133A

DRD2 TRPC5 KAT6A NEB NEK11 ZNF710

1.62e-042009263036_DN
DrugPentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A

KAT6A RO60 DGCR8 CBL HCFC1 ZFX

1.62e-042009265264_DN
Drugchrysene

TOX4 PIEZO1 EIF4G1 MKI67 RASGEF1C MUC16 SHISA2 NEB DICER1 AREG ZNF710 CDHR4

1.99e-048719212ctd:C031180
Diseasecongenital heart disease (implicated_via_orthology)

KMT2A HCFC1 AXIN2 SON

5.51e-0569884DOID:1682 (implicated_via_orthology)
Diseasemucositis (biomarker_via_orthology)

MKI67 MUC4

8.74e-055882DOID:0080178 (biomarker_via_orthology)
DiseaseChild Development Disorders, Specific

CNTN4 DRD2 CBL

8.85e-0529883C0085997
DiseaseChild Development Deviations

CNTN4 DRD2 CBL

8.85e-0529883C0085996
DiseaseBipolar Disorder

SLC12A6 CNTN4 DRD2 SHANK2 PDE9A SLC1A1 ALOX12 VDR

9.13e-05477888C0005586
Diseasehair colour measurement

FREM2 RIN3 PIEZO1 AKAP13 HERC2 ATP10A AREG AXIN2 PPP6R3

9.26e-05615889EFO_0007822
Diseaseautism spectrum disorder (implicated_via_orthology)

NRXN3 SHANK2 TRPC5 NBEA DSCAML1

9.43e-05152885DOID:0060041 (implicated_via_orthology)
DiseaseDevelopmental Disabilities

CNTN4 DRD2 CBL

9.82e-0530883C0008073
Diseasechronic obstructive pulmonary disease

AKAP6 RIN3 ARHGEF28 RPAP1 PIEZO1 RASGEF1C POM121L2 CHRNB4 TWIST1

2.14e-04688889EFO_0000341
DiseaseCornelia De Lange Syndrome

KMT2A RAD21

2.43e-048882C0270972
Diseasediffuse large B-cell lymphoma (is_marker_for)

MKI67 DICER1

2.43e-048882DOID:0050745 (is_marker_for)
DiseaseColorectal Carcinoma

AKAP6 CNTN4 RPAP1 MAP1B EIF4G1 MKI67 ZNF217 DSCAML1 AXIN2

2.49e-04702889C0009402
DiseaseFEV/FEC ratio

AKAP6 FREM2 ARHGEF28 RPAP1 PDE9A U2SURP RASGEF1C RSPH6A NEB GTF2IRD1 CDHR4 TWIST1

2.83e-0412288812EFO_0004713
DiseasePituitary Adenoma

DRD2 DICER1

3.12e-049882C0032000
Diseaseinflammatory biomarker measurement, YKL40 measurement

CNTN4 ARHGEF28 VDR

4.81e-0451883EFO_0004869, EFO_0004872
Diseasesialic acid-binding Ig-like lectin 14 measurement

ARHGEF28 SIGLEC5

5.69e-0412882EFO_0008284
Diseasenicotine dependence (implicated_via_orthology)

DRD2 TRPC5

5.69e-0412882DOID:0050742 (implicated_via_orthology)
DiseasePeripheral Nervous System Diseases

SLC12A6 MKI67 ALOX12

5.70e-0454883C4721453
Diseasecholangiocarcinoma (is_marker_for)

MKI67 MUC16 MUC4

9.36e-0464883DOID:4947 (is_marker_for)
DiseaseSchizoaffective disorder-bipolar type

NRXN3 RAD21

1.03e-0316882EFO_0009965
Diseasebreast cancer (is_implicated_in)

MKI67 AREG TWIST1 VDR

1.07e-03150884DOID:1612 (is_implicated_in)
Diseasegait measurement

AKAP6 DRD2 NRXN3 POM121L2

1.07e-03150884EFO_0007680
DiseaseAutistic Disorder

CNTN4 NRXN3 SHANK2 NBEA ATP10A

1.12e-03261885C0004352
Diseaseresponse to phenylephrine

ATP10A NEK11

1.16e-0317882EFO_0010152
DiseaseAlcoholic Intoxication, Chronic

CNTN4 DRD2 NRXN3 DSCAML1 CHRNB4

1.26e-03268885C0001973
DiseaseMyeloid Leukemia

KMT2A RAD21

1.30e-0318882C0023470
DiseaseLeukemia, Monocytic, Chronic

KMT2A RAD21

1.30e-0318882C0023466
DiseaseEndometrioma

SLC1A1 ANKH DICER1 AREG

1.39e-03161884C0269102
DiseaseEndometriosis

SLC1A1 ANKH DICER1 AREG

1.39e-03161884C0014175
DiseaseDiGeorge syndrome (implicated_via_orthology)

KAT6A DICER1

1.45e-0319882DOID:11198 (implicated_via_orthology)
Diseasebone density, lean body mass

RIN3 PPP6R3

1.78e-0321882EFO_0003923, EFO_0004995
DiseaseObsessive-compulsive trait

MUC22 NEK11

1.78e-0321882HP_0008770
DiseaseHodgkins lymphoma

ZNF526 ARHGEF28 SHANK2

1.91e-0382883EFO_0000183
DiseaseStomach Neoplasms

CLCN3 KMT2A AREG AXIN2 TWIST1

1.98e-03297885C0038356
Diseaseacute myeloid leukemia (is_implicated_in)

KAT6A KMT2A CBL

2.05e-0384883DOID:9119 (is_implicated_in)
DiseaseMalignant neoplasm of stomach

CLCN3 KMT2A AREG AXIN2 TWIST1

2.07e-03300885C0024623
Diseaselung adenocarcinoma (is_marker_for)

MKI67 MUC4 CHRNB4

2.12e-0385883DOID:3910 (is_marker_for)
DiseaseEpilepsy, Benign Psychomotor, Childhood

SLC1A1 VDR

2.14e-0323882C0393672
DiseaseEpilepsy, Lateral Temporal

SLC1A1 VDR

2.14e-0323882C0393682
DiseaseUncinate Epilepsy

SLC1A1 VDR

2.14e-0323882C0014558
DiseaseEpilepsy, Temporal Lobe

SLC1A1 VDR

2.14e-0323882C0014556
Diseasesuicidal ideation, suicide behaviour

DRD2 POM121L2

2.33e-0324882EFO_0004320, EFO_0007623
Diseasehair color

CNTN4 FREM2 HERC2 AREG AXIN2

2.42e-03311885EFO_0003924
DiseaseProstatic Neoplasms

KAT6A KMT2A AKAP13 RPRD2 SMARCAD1 MUC4 VDR

2.47e-03616887C0033578
DiseaseMalignant neoplasm of prostate

KAT6A KMT2A AKAP13 RPRD2 SMARCAD1 MUC4 VDR

2.47e-03616887C0376358
Diseaseforced expiratory volume

RIN3 NRXN3 PIEZO1 RASGEF1C POM121L2 RPRD2 RBM20 TWIST1

2.47e-03789888EFO_0004314
Diseaselarge artery stroke, coronary artery disease

CHRNB4 TWIST1

2.52e-0325882EFO_0001645, EFO_0005524
Diseasebreast cancer, lung cancer

RIN3 POM121L2

2.52e-0325882MONDO_0007254, MONDO_0008903
Diseaseosteoarthritis, hip

PIEZO1 RPRD2 HERC2

2.66e-0392883EFO_1000786
DiseaseIschemic stroke

PDE9A SLC14A1 SLC1A1 ZNF691 TWIST1

2.88e-03324885HP_0002140
Diseaserefractive error

AKAP6 SLC12A6 NBEA FAAP100 DSCAML1

2.96e-03326885MONDO_0004892

Protein segments in the cluster

PeptideGeneStartEntry
MEAMAASTSLPDPGD

VDR

1

P11473
MTPTASMDDFTPSGE

CHRNB4

186

P30926
MEEMSGESVVSSAVP

KCTD10

1

Q9H3F6
DLMSSAVPMTPEDPS

AASDHPPT

276

Q9NRN7
EMSSGSEISPVSEMP

AREG

56

P15514
PCTATSGPMSEMSSI

ADGRG4

1551

Q8IZF6
MMTAQDPSSAPETDG

AKAP13

301

Q12802
DPTRVMVPPSSMDVT

CNTN4

496

Q8IWV2
MVPPSSMDVTVGESI

CNTN4

501

Q8IWV2
SMSMTDSSVDGIPPY

AXIN2

311

Q9Y2T1
SDHPSDGETSVQPMM

DGCR8

271

Q8WYQ5
TSDGSPVMAVMPGTT

DICER1

1251

Q9UPY3
VPSTMTPMLVTDTEA

CDHR4

666

A6H8M9
ASGEPSTVDMSMPVR

ATP10A

1366

O60312
SASTSCPSDMDVEMP

RBM20

986

Q5T481
VDPVEPMPTMTDQTT

RAD21

281

O60216
MGSSPSTESFIMEDV

ARHGEF28

796

Q8N1W1
VMGTGEPMDTSEAAA

HCFC1

1646

P51610
STTTPNPEVGMSTMD

MUC16

3551

Q8WXI7
NPEVGMSTMDSTPAT

MUC16

3556

Q8WXI7
TSMPGSSEITRIEME

MUC16

6636

Q8WXI7
SGMTTPMSRGPEDVS

MUC16

8826

Q8WXI7
METAPPDEMTTSFPS

MUC4

111

Q99102
TVSSDSPLKMETPGM

MUC4

4251

Q99102
ISSEPTPMDEMSTPR

MAP1B

1126

P46821
TPMDEMSTPRDVMSD

MAP1B

1131

P46821
MTTDDTEVPAMTLAP

MUC20

36

Q8N307
MGSETTMASTIGPET

MUC22

551

E2RYF6
PSDASAMASPMNGEE

HERC2

3436

O95714
PGPGVESMAVASMTS

EPN2

581

O95208
ETVGSMTPDIMETVT

GARIN4

576

Q8IYT1
VSSPMDTVTEAGMAI

IMPDH2

66

P12268
EEMSSMADVTFPSVP

FREM2

2361

Q5SZK8
TDDAMVSIDPTMPAN

PDE9A

56

O76083
TSMPPEMSTTVMETT

NRXN3

1276

Q9Y4C0
ETTMPPSETATSETM

DEFB125

131

Q8N687
DTKTITTMAEDMSPG

NEK11

541

Q8NG66
TPGPSEESMTDEKTT

MKI67

1111

P46013
PTTKEDVTMATVMGS

ALOX12

566

P18054
LDSEMPGPARMTTES

FAAP100

436

Q0VG06
MSSENTTGPPSSMDR

ITPRID2

676

P28290
TSMQPTEAMGEEPSR

ICAM3

531

P32942
EDMTPTEQTPRGSME

PRICKLE2

531

Q7Z3G6
NMETSPMMDVPSVSD

KAT6A

1526

Q92794
VTPAEEMGDTAMIST

BOD1L1

2281

Q8NFC6
EEGMSETPMLPSSLM

CABIN1

876

Q9Y6J0
NADSMTSMSTPSEPG

DSCAML1

1851

Q8TD84
EGEDSAMTDMPPTEE

ANKH

466

Q9HCJ1
AMTDMPPTEEVTDIV

ANKH

471

Q9HCJ1
MQVPTAEEMSSLTPE

BRSK1

571

Q8TDC3
PGDTMTTIQMSVEES

EIF4G1

286

Q04637
TPSVMETNTSVLGPM

KMT2A

3111

Q03164
SMSMNSSPLVGPECD

CBL

646

P22681
AQELEMEMLSSTSPP

DRD2

276

P14416
PSPTSEEMTDSMPGH

GTF2IRD1

511

Q9UHL9
GTPTQDEMMDKPTSS

RPRD2

731

Q5VT52
VPETSRSEPMSEMSG

SLC12A6

51

Q9UHW9
EVETVMSEVSGFPMP

BYSL

161

Q13895
PPSDPEMNMTEESFT

SLC1A1

171

P43005
SSDTDSPATMGGMVA

LIPE

241

Q05469
TSPISTDGMAEELTM

PRDM4

201

Q9UKN5
DLGVTTSVPEVPMME

RIN3

726

Q8TB24
GSSSLTSEDPVTMMD

HSF2

331

Q03933
CPSMGENTMKTEPTS

PHF20

401

Q9BVI0
MMAVTKEAPETDTSP

MRPS31

261

Q92665
ETMSMPQLTVPASGS

RTL9

521

Q8NET4
SGPEIMEMSDPTVEE

RSPH6A

671

Q9H0K4
MTTVDEGDEGSMPAD

SMARCAD1

1001

Q9H4L7
TSMPPEMSTTVMETT

NRXN3

271

Q9HDB5
VAPMPEDSAENMSIT

NBEA

1871

Q8NFP9
EDSEPSTGMNYTPSM

SLC9B2

11

Q86UD5
MDDEDPIMGTITSGS

SIGLEC5

476

O15389
METIPMIPSASTSRG

SHISA2

161

Q6UWI4
SVESMITTLDPGMAP

PRRC1

236

Q96M27
GSDVFEEPMSGMSEA

SUPT7L

361

O94864
EEPMSGMSEAGIPQS

SUPT7L

366

O94864
TAPVQMPTAESTGMT

PMEL

361

P40967
VSEVMGTTLAEMSTP

PMEL

381

P40967
GTTLAEMSTPEATGM

PMEL

386

P40967
EMSTPEATGMTPAEV

PMEL

391

P40967
SDEMVPCPVTTDMTL

RO60

416

P10155
SSPQSTEAPMLDGMS

ARHGAP44

751

Q17R89
DESGIIMTGPDMSPT

POM121L2

901

Q96KW2
MPRSPTSSEDEMAQS

SHANK2

1

Q9UPX8
MDASGPSDSDMPSRT

U2SURP

31

O15042
TDASPMAINMTPTVE

AKAP6

21

Q13023
DMSPFTVTDHTPMEI

CLCN3

756

P51790
TSPIPEMEAMSPTTQ

C11orf24

311

Q96F05
EMLPLSSEGSEMGSE

ZNF691

21

Q5VV52
NMTDTGISPMSTRDP

SAGE1

231

Q9NXZ1
MPQTLSASDMVTPGS

RASGEF1C

1

Q8N431
DSQDPMMELTGTDPS

ZNF710

606

Q8N1W2
TPSGLSPTDTMGTAM

RPAP1

1116

Q9BWH6
MEDSPTMVRVDSPTM

SLC14A1

1

Q13336
GSSGMTMDTESEIDP

ZFX

226

P17010
PEVIGSSLGSPMEME

ZNF217

21

O75362
SPGAVEMSTPMSAEM

ZNF526

16

Q8TF50
MSEPSSEPMYTISDG

TRPC5

856

Q9UL62
AEEPLSSMTDDMGSP

PIEZO1

1596

Q92508
PVEMETSTEPMDPLT

PPP6R3

741

Q5H9R7
MMQDVSSSPVSPADD

TWIST1

1

Q15672
VTCMVSETPAMSAEP

SON

1281

P18583
EPPVMSETAETFDSM

SON

1301

P18583
PVTIDVPMTDMTSGL

TOX4

121

O94842
EDIPIVPTTSGTMME

PPIP5K1

376

Q6PFW1
PDTVKFTSVPDSMGM

NEB

1476

P20929