Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

PRDM16 PRDM6 SMYD3

5.16e-0468463GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

PRDM16 PRDM6 SMYD3

5.39e-0469463GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

PRDM16 PRDM6 SMYD3

5.86e-0471463GO:0042054
GeneOntologyMolecularFunctionhistone H4 methyltransferase activity

PRDM6 SMYD3

6.91e-0417462GO:0140939
GeneOntologyMolecularFunctionstructural molecule activity

LTBP2 EFEMP1 CILP MUC5AC KRTAP27-1 KRT38 KRT37 OC90

8.79e-04891468GO:0005198
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LTBP2 EFEMP1 CILP MUC5AC

9.12e-04188464GO:0005201
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP4

9.61e-0420462GO:0034185
GeneOntologyMolecularFunctioncalcium ion binding

LRP1 LRP4 EYS LTBP2 EFEMP1 OC90 PROS1

1.52e-03749467GO:0005509
GeneOntologyMolecularFunctionprotein methyltransferase activity

PRDM16 PRDM6 SMYD3

1.72e-03103463GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

PRDM16 PRDM6 SMYD3

1.82e-03105463GO:0008170
GeneOntologyCellularComponentextracellular matrix

EYS MUC5B LTBP2 SERPINB9 EFEMP1 COL26A1 CILP MUC5AC TNN OC90

1.27e-066564610GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

EYS MUC5B LTBP2 SERPINB9 EFEMP1 COL26A1 CILP MUC5AC TNN OC90

1.31e-066584610GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

EYS LTBP2 SERPINB9 EFEMP1 COL26A1 CILP TNN

1.47e-04530467GO:0062023
DomainEGF_3

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

3.28e-09235449PS50026
DomainEGF

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

3.28e-09235449SM00181
DomainASX_HYDROXYL

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 PROS1

3.32e-09100447PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 PROS1

5.00e-09106447IPR000152
DomainEGF-like_dom

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

5.44e-09249449IPR000742
DomainEGF_1

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

6.69e-09255449PS00022
DomainEGF-like_CS

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

8.19e-09261449IPR013032
DomainEGF_2

LRP1 LRP4 EYS LTBP2 NRXN3 EFEMP1 MALRD1 TNN PROS1

9.35e-09265449PS01186
DomainEGF

LRP1 LRP4 EYS LTBP2 NRXN3 MALRD1 PROS1

1.67e-08126447PF00008
DomainGrowth_fac_rcpt_

LRP1 LRP4 EYS LTBP2 EFEMP1 TNN PROS1

7.33e-08156447IPR009030
DomainEGF_Ca-bd_CS

LRP1 LRP4 EYS LTBP2 EFEMP1 PROS1

1.01e-0797446IPR018097
DomainEGF_CA

LRP1 LRP4 EYS LTBP2 EFEMP1 PROS1

1.14e-0799446PS01187
DomainWxxW_domain

MUC5B CILP MUC5AC

2.43e-076443IPR025155
DomainMucin2_WxxW

MUC5B CILP MUC5AC

2.43e-076443PF13330
DomainEGF_CA

LRP1 LRP4 EYS LTBP2 EFEMP1 PROS1

3.96e-07122446SM00179
DomainEGF-like_Ca-bd_dom

LRP1 LRP4 EYS LTBP2 EFEMP1 PROS1

4.35e-07124446IPR001881
DomainEGF_CA

LRP1 LRP4 LTBP2 EFEMP1 PROS1

1.74e-0686445PF07645
DomainConA-like_dom

PAPPA2 EYS NRXN3 MALRD1 MID2 PROS1

1.18e-05219446IPR013320
DomaincEGF

LRP1 LRP4 EFEMP1

3.05e-0526443IPR026823
DomaincEGF

LRP1 LRP4 EFEMP1

3.05e-0526443PF12662
Domain-

PAPPA2 EYS NRXN3 PROS1

7.30e-05954442.60.120.200
DomainLAM_G_DOMAIN

EYS NRXN3 PROS1

9.71e-0538443PS50025
Domain-

LRP1 LRP4 TRIM2

1.05e-04394432.120.10.30
DomainLaminin_G_2

EYS NRXN3 PROS1

1.13e-0440443PF02210
DomainLDLR_class-A_CS

LRP1 LRP4 MALRD1

1.13e-0440443IPR023415
DomainLamG

EYS NRXN3 PROS1

1.51e-0444443SM00282
DomainLdl_recept_a

LRP1 LRP4 MALRD1

1.62e-0445443PF00057
DomainSET

PRDM16 PRDM6 SMYD3

1.73e-0446443SM00317
Domain-

LRP1 LRP4 MALRD1

1.73e-04464434.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP1 LRP4 TRIM2

1.73e-0446443IPR011042
DomainLDLRA_1

LRP1 LRP4 MALRD1

1.96e-0448443PS01209
DomainLDrepeatLR_classA_rpt

LRP1 LRP4 MALRD1

2.08e-0449443IPR002172
DomainLDLa

LRP1 LRP4 MALRD1

2.08e-0449443SM00192
DomainLDLRA_2

LRP1 LRP4 MALRD1

2.08e-0449443PS50068
DomainSET_dom

PRDM16 PRDM6 SMYD3

2.21e-0450443IPR001214
DomainSET

PRDM16 PRDM6 SMYD3

2.21e-0450443PS50280
DomainLaminin_G_1

EYS PROS1

2.94e-0411442PF00054
DomainLaminin_G

EYS NRXN3 PROS1

3.44e-0458443IPR001791
DomainTIL

MUC5B MUC5AC

3.53e-0412442PF01826
DomainC8

MUC5B MUC5AC

3.53e-0412442PF08742
DomainUnchr_dom_Cys-rich

MUC5B MUC5AC

4.16e-0413442IPR014853
DomainC8

MUC5B MUC5AC

4.16e-0413442SM00832
DomainLdl_recept_b

LRP1 LRP4

4.85e-0414442PF00058
DomainLDLRB

LRP1 LRP4

4.85e-0414442PS51120
DomainTIL_dom

MUC5B MUC5AC

4.85e-0414442IPR002919
DomainBbox_C

TRIM2 MID2

5.59e-0415442IPR003649
DomainGlyco_hormone_CN

MUC5B MUC5AC

5.59e-0415442IPR006208
DomainCys_knot

MUC5B MUC5AC

5.59e-0415442PF00007
DomainBBC

TRIM2 MID2

5.59e-0415442SM00502
DomainLY

LRP1 LRP4

5.59e-0415442SM00135
DomainLDLR_classB_rpt

LRP1 LRP4

5.59e-0415442IPR000033
DomainVWFD

MUC5B MUC5AC

6.37e-0416442PS51233
DomainVWD

MUC5B MUC5AC

6.37e-0416442SM00216
DomainVWF_type-D

MUC5B MUC5AC

6.37e-0416442IPR001846
DomainVWD

MUC5B MUC5AC

6.37e-0416442PF00094
DomainCTCK_1

MUC5B MUC5AC

8.10e-0418442PS01185
DomainVWC_out

MUC5B MUC5AC

9.04e-0419442SM00215
Domainzf-MYND

DEAF1 SMYD3

1.11e-0321442PF01753
DomainZnf_MYND

DEAF1 SMYD3

1.22e-0322442IPR002893
DomainZF_MYND_1

DEAF1 SMYD3

1.22e-0322442PS01360
DomainCT

MUC5B MUC5AC

1.22e-0322442SM00041
DomainZF_MYND_2

DEAF1 SMYD3

1.22e-0322442PS50865
DomainCys_knot_C

MUC5B MUC5AC

1.57e-0325442IPR006207
DomainCTCK_2

MUC5B MUC5AC

1.57e-0325442PS01225
DomainVWC

MUC5B MUC5AC

1.97e-0328442PF00093
Pubmed

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

LRP1 TGFBR2 TSC1 PRDM16 SMYD3

6.35e-087846523793025
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

PAPPA2 MUC5B LTBP2 SERPINB9 EFEMP1 CILP KRT38 KRT37 PROS1 MPI

1.09e-061070461023533145
Pubmed

Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).

MUC5B MUC5AC

1.71e-0624627513696
Pubmed

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.

MUC5B MUC5AC

1.71e-06246234058148
Pubmed

The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.

MUC5B MUC5AC

1.71e-06246237146737
Pubmed

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

MUC5B MUC5AC

1.71e-06246214988081
Pubmed

Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.

MUC5B MUC5AC

1.71e-06246215563276
Pubmed

The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.

MUC5B MUC5AC

1.71e-06246217621824
Pubmed

Muc5b is required for airway defence.

MUC5B MUC5AC

1.71e-06246224317696
Pubmed

Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.

MUC5B MUC5AC

1.71e-06246222391959
Pubmed

C-Mannosylation of MUC5AC and MUC5B Cys subdomains.

MUC5B MUC5AC

1.71e-06246214718370
Pubmed

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

MUC5B MUC5AC

1.71e-06246235776514
Pubmed

The ocular surface phenotype of Muc5ac and Muc5b null mice.

MUC5B MUC5AC

1.71e-06246224327612
Pubmed

Mucin production during prenatal and postnatal murine lung development.

MUC5B MUC5AC

1.71e-06246221653907
Pubmed

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.

MUC5B MUC5AC

1.71e-06246236427316
Pubmed

Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA.

TGFBR2 ELF3

1.71e-06246220054123
Pubmed

Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1.

TGFBR2 ELF3

1.71e-06246211893733
Pubmed

Gel-forming mucins form distinct morphologic structures in airways.

MUC5B MUC5AC

1.71e-06246228607090
Pubmed

Mucin deficiency causes functional and structural changes of the ocular surface.

MUC5B MUC5AC

1.71e-06246223272068
Pubmed

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.

MUC5B MUC5AC

1.71e-06246231030254
Pubmed

Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.

MUC5B MUC5AC

1.71e-06246227729120
Pubmed

The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.

MUC5B MUC5AC

1.71e-06246223527003
Pubmed

Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.

MUC5B MUC5AC

1.71e-06246216540890
Pubmed

De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.

MUC5B MUC5AC

1.71e-06246236111525
Pubmed

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

MUC5B MUC5AC

1.71e-06246227845589
Pubmed

Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA.

TGFBR2 ELF3

1.71e-06246220079749
Pubmed

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

MUC5B MUC5AC

1.71e-06246227435107
Pubmed

Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.

MUC5B MUC5AC

1.71e-06246226871672
Pubmed

TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.

TGFBR2 ELF3

1.71e-06246217408644
Pubmed

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.

MUC5B MUC5AC

1.71e-06246232348677
Pubmed

In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.

MUC5B MUC5AC

1.71e-06246211587997
Pubmed

Effect of ets-related transcription factor (ERT) on transforming growth factor (TGF)-beta type II receptor gene expression in human cancer cell lines.

TGFBR2 ELF3

1.71e-06246214582709
Pubmed

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.

MUC5B MUC5AC

1.71e-06246224332705
Pubmed

Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.

MUC5B MUC5AC

1.71e-06246234656442
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP1 MED13L DMAC2L MUC5AC

2.44e-067146433541421
Pubmed

Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.

MUC5B MUC5AC

5.13e-06346227776277
Pubmed

HNE Induces the Hyperexpression of MUC5AC in Chronic Rhinosinusitis With Nasal Polyps by Activating the TRAF6/Autophagy Regulatory Axis.

TRAF6 MUC5AC

5.13e-06346235915986
Pubmed

High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.

MUC5B MUC5AC

5.13e-06346229286856
Pubmed

Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.

MUC5B MUC5AC

5.13e-06346236675209
Pubmed

Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.

LRP1 PRDM16

5.13e-06346235454329
Pubmed

Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.

MUC5B MUC5AC

5.13e-06346229802623
Pubmed

Home Dust Mites Promote MUC5AC Hyper-Expression by Modulating the sNASP/TRAF6 Axis in the Airway Epithelium.

TRAF6 MUC5AC

5.13e-06346236012669
Pubmed

Genetics of migraine in the age of genome-wide association studies.

LRP1 PRDM16

5.13e-06346222072275
Pubmed

Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.

MUC5B MUC5AC

5.13e-06346234158522
Pubmed

Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.

MUC5B MUC5AC

5.13e-06346229604272
Pubmed

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.

MUC5B MUC5AC

5.13e-06346219596978
Pubmed

Susceptible gene single nucleotide polymorphism and hemorrhage risk in patients with brain arteriovenous malformation.

TGFBR2 LTBP2

5.13e-06346221737283
Pubmed

Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.

MUC5B MUC5AC

5.13e-06346219556605
Pubmed

Aquaporin 5 expression increases mucin production in lung adenocarcinoma.

MUC5B MUC5AC

5.13e-06346221455588
Pubmed

TNF receptor-associated factor 6 (TRAF6) mediates the angiotensin-induced non-canonical TGF-β pathway activation of c-kit(+) cardiac stem cells.

TGFBR2 TRAF6

5.13e-06346226807171
Pubmed

Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.

MUC5B MUC5AC

5.13e-06346220422702
Pubmed

Genome-wide association study reveals three susceptibility loci for common migraine in the general population.

LRP1 PRDM16

5.13e-06346221666692
Pubmed

Mucin gene polymorphisms in otitis media patients.

MUC5B MUC5AC

5.13e-06346219718741
Pubmed

ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.

MUC5B MUC5AC

1.03e-05446231582416
Pubmed

Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.

MUC5B MUC5AC

1.03e-05446225638393
Pubmed

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.

MUC5B MUC5AC

1.03e-05446217471237
Pubmed

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.

MUC5B MUC5AC

1.03e-05446221097527
Pubmed

Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.

MUC5B MUC5AC

1.03e-05446222269464
Pubmed

The mouse secreted gel-forming mucin gene cluster.

MUC5B MUC5AC

1.03e-05446214984930
Pubmed

TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.

MUC5B MUC5AC

1.03e-05446223249391
Pubmed

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.

MUC5B MUC5AC

1.03e-05446229869461
Pubmed

Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.

MUC5B MUC5AC

1.03e-05446218258655
Pubmed

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.

MUC5B MUC5AC

1.03e-05446223807779
Pubmed

Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies.

LRP1 TGFBR2

1.03e-05446235143327
Pubmed

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

MUC5B MUC5AC

1.03e-05446212676567
Pubmed

Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

MUC5B MUC5AC

1.71e-05546211062147
Pubmed

PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.

TRAF6 MUC5AC

1.71e-05546222303480
Pubmed

Differential expression of MUC genes in endometrial and cervical tissues and tumors.

MUC5B MUC5AC

1.71e-05546216188033
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP4

1.71e-05546219047013
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC5B MUC5AC

2.56e-05646219110483
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

LRP1 MUC5B MUC5AC

3.37e-054746311208732
Pubmed

Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development.

TGFBR2 ELF3

3.58e-05746219801644
Pubmed

Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development.

TGFBR2 TNN

3.58e-05746232581832
Pubmed

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta.

TGFBR2 TRAF6

4.77e-05846218922473
Pubmed

MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.

TRAF6 MUC5AC

4.77e-05846218782768
Pubmed

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

LRP1 LRP4

6.12e-05946223986861
Pubmed

Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

KRT38 KRT37

6.12e-0594629756910
Pubmed

Human hair keratins.

KRT38 KRT37

6.12e-0594627686952
Pubmed

The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.

KRT38 KRT37

7.65e-051046210391933
Pubmed

Genome-wide association analysis identifies susceptibility loci for migraine without aura.

LRP1 TGFBR2

7.65e-051046222683712
Pubmed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

MUC5B MUC5AC

9.34e-051146224429156
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP4

9.34e-051146224639464
Pubmed

The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

KRT38 KRT37

1.12e-041246215617563
Pubmed

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

LRP1 LRP4

1.32e-041346216207730
Pubmed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.

MUC5B MUC5AC

1.54e-041446222797898
Pubmed

Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.

OC90 TG

1.54e-041446216964447
Pubmed

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.

LRP1 LRP4

1.78e-041546220205790
Pubmed

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

PRDM16 PRDM6

2.03e-041646225035420
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC5B MUC5AC

2.58e-041846218834073
Pubmed

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

PAPPA2 SMYD3

2.88e-041946224315451
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP4

3.54e-042146221337463
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM16 PRDM6

3.89e-042246219050759
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

TGFBR2 TRIM2 EFEMP1 MID2 KRT38 PROS1

4.19e-0474246626871637
Pubmed

Klf14 is an imprinted transcription factor that regulates placental growth.

LTBP2 COL26A1

4.25e-042346231675530
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

TRIM2 MID2

5.88e-042746221143188
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

TRAF6 MID2

6.33e-042846235474067
Pubmed

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

TRAF6 SMYD3

7.77e-043146226678539
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PAPPA2 LTBP2 EFEMP1

7.85e-0413646325429064
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

TRAF6 NRXN3

8.80e-043346222357600
Pubmed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

LTBP2 EFEMP1 CILP

9.64e-0414646327068509
InteractionZNF778 interactions

LRP4 LTBP2 EFEMP1

1.48e-0611433int:ZNF778
Cytoband11p15.5

MUC5B DEAF1 MUC5AC

2.32e-0411846311p15.5
Cytoband15q22

CILP MPI

3.92e-042946215q22
Cytoband17q12-q21

KRT38 KRT37

4.78e-043246217q12-q21
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR56A3 MUC5B DEAF1 MUC5AC

2.44e-03564464chr11p15
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

PRDM16 PRDM6 SMYD3

2.38e-0534303487
GeneFamilyLow density lipoprotein receptors

LRP1 LRP4

2.05e-0413302634
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM16 PRDM6

3.56e-04173021197
GeneFamilyCD molecules|Mucins

MUC5B MUC5AC

5.48e-0421302648
GeneFamilyZinc fingers MYND-type

DEAF1 SMYD3

5.48e-042130287
GeneFamilyKeratins, type I

KRT38 KRT37

9.79e-0428302608
GeneFamilyRing finger proteins

TRAF6 TRIM2 MID2

1.04e-0227530358
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM2 MID2

1.08e-029530259
GeneFamilyFibronectin type III domain containing

MID2 TNN

2.88e-02160302555
CoexpressionNABA_MATRISOME

PAPPA2 EYS MUC5B LTBP2 SERPINB9 EFEMP1 COL26A1 CILP MUC5AC TNN

5.96e-0610264410M5889
CoexpressionNABA_CORE_MATRISOME

EYS LTBP2 EFEMP1 COL26A1 CILP TNN

6.38e-06275446M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

EYS LTBP2 EFEMP1 CILP TNN

1.90e-05196445M3008
CoexpressionNABA_MATRISOME_POORLY_METASTATIC_MELANOMA

LTBP2 EFEMP1 TNN

3.57e-0538443M47982
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP

LRP4 TRIM2 EFEMP1 PROS1

3.63e-05111444M1348
CoexpressionNABA_MATRISOME

PAPPA2 MUC5B LTBP2 SERPINB9 EFEMP1 COL26A1 CILP MUC5AC TNN

3.74e-051008449MM17056
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP

LRP4 TRIM2 EFEMP1 PROS1

6.33e-05128444MM1000
CoexpressionNABA_CORE_MATRISOME

LTBP2 EFEMP1 COL26A1 CILP TNN

8.74e-05270445MM17057
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

HIPK3 OR56A3 TSC1 TUT4 EFEMP1 DMAC2L SMYD3

7.11e-06359437Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 LTBP2 TEX15 EFEMP1 PRDM6

8.28e-071684654b2d29a7843bf45922038c093ca7ec0600756adc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 LTBP2 TEX15 EFEMP1 PRDM6

9.04e-071714655d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.07e-06177465779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.07e-061774650f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.23e-061824653f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LTBP2 TRIM2 MALRD1 PRDM16

1.30e-06184465e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

ELF3 CACHD1 NRXN3 TRIM2 PRDM16

1.33e-06185465cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LTBP2 TRIM2 MALRD1 PRDM16

1.40e-061874657ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LTBP2 TRIM2 MALRD1 PRDM16

1.44e-061884652ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

ELF3 MUC5B CACHD1 TRIM2 MUC5AC

1.48e-0618946584d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellIPF-Epithelial-Goblet|IPF / Disease state, Lineage and Cell class

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.52e-06190465e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LTBP2 TRIM2 MALRD1 PRDM16

1.52e-061904653dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.52e-0619046551ca9ef4df3220487152fcf684147730637c7cc1
ToppCellIPF-Epithelial-Goblet|World / Disease state, Lineage and Cell class

ELF3 MUC5B NRXN3 TRIM2 MUC5AC

1.52e-06190465c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 LTBP2 TRIM2 MALRD1 PRDM16

1.60e-06192465562df5e87038c500dd3a003fe5374cb31946b145
ToppCellFibroblast-B_(Myofibroblast)|World / shred on cell class and cell subclass (v4)

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.72e-06195465a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.77e-061964659d7b631f24a19a7dc7a28f28525d4019fc8fcf8a
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-061974657d97c2d51a543c02d679e9257b22d0581e73a11d
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-061974659d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-06197465090a251194da3e2806989d9a522588f83f52da7f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-0619746543b5f8e917506c1717f9311584901b506ffd2c79
ToppCellP03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-061974652cec938caf6ffd031cea37277071487e59b2c71c
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 NRXN3 PRDM6 PROS1

1.81e-06197465671d6b5effbac2dd71d18f48d23c523738db1828
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FAM170B LTBP2 EFEMP1 CILP

1.05e-05132464893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCellClub_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

LRP4 ELF3 MUC5B CILP

1.25e-05138464133015953fc660d00339f47b415da5e9872313a2
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

EYS NRXN3 TEX15 MALRD1

1.29e-0513946464c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINB9 EFEMP1 COL26A1 CILP

2.24e-051604648590281165eab6514a9f6a022b900d4c222c1044
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 TRIM2

2.29e-051614642d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 MUC5B CCDC180 DNAH1

2.46e-05164464e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELF3 CACHD1 TRIM2 PRDM16

2.58e-05166464c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellLPS-antiTNF-Epithelial_airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 MUC5B CCDC180 PRDM16

2.58e-05166464eb942ed68677e55c46cb039046f45686d4062d7c
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 MUC5AC

2.65e-051674646efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MUC5B EFEMP1 MALRD1 MUC5AC

2.97e-051724640be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 MUC5AC

3.04e-05173464464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 MUC5AC

3.11e-051744647d2f802f493f19a068e097b2909a9000e2160266
ToppCellClub_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ELF3 MUC5B TRIM2 MUC5AC

3.39e-05178464be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ELF3 MUC5B TRIM2 MUC5AC

3.47e-051794646e965e424eebef50f0202cff75f458be395cfca1
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 MUC5AC

3.47e-051794641fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 LRP4 LTBP2 PRDM6

3.47e-0517946402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

3.47e-0517946404ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellControl-Epithelial-Goblet|Control / Disease state, Lineage and Cell class

ELF3 MUC5B TRIM2 MUC5AC

3.55e-051804645293d23b8b8ea587239ffde561b70bad01632521
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 LRP4 EFEMP1 PRDM6

3.62e-05181464091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA2 LTBP2 PRDM6 TNN

3.62e-05181464eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA2 LTBP2 PRDM6 TNN

3.62e-051814649c157de9d3403e092c907599f2a2c16db5b21131
ToppCellP28-Mesenchymal|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 LRP4 EFEMP1 PRDM6

3.70e-0518246469f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 LRP4 LTBP2 PRDM6

3.78e-051834647eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

3.78e-05183464ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP4 LTBP2 CILP PRDM6

3.78e-0518346406a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

ELF3 MUC5B NRXN3 MUC5AC

3.78e-05183464940cbe298e9c53b5622af09264586ed823d3141f
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA2 LTBP2 PRDM6 TNN

3.78e-05183464bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

3.86e-05184464cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 LRP4 EFEMP1 PRDM6

3.86e-05184464924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

3.95e-051854643bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

ELF3 CACHD1 TRIM2 MALRD1

3.95e-05185464673f0c688ae6984bc8027df2da335787924f4137
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LRP4 EFEMP1 CILP

3.95e-05185464eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LRP4 EFEMP1 CILP

3.95e-05185464f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

3.95e-05185464c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LRP4 EFEMP1 CILP

3.95e-05185464ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.03e-0518646473cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELF3 NRXN3 EFEMP1 PRDM16

4.03e-051864643aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ELF3 EFEMP1 PRDM16 MUC5AC

4.20e-051884643cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 TRIM2 MALRD1 PRDM16

4.20e-051884643cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.29e-0518946440cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 TRIM2 MALRD1 PRDM16

4.29e-05189464f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 LTBP2 EFEMP1 CILP

4.29e-05189464d531399749409d614adca13d181830c6e3287508
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.29e-05189464bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.38e-0519046478cc6c28b31de041c24175a98f47da256ecc15a2
ToppCellE17.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ELF3 WDR45 SERPINB9 TRIM2

4.38e-051904648e9ba1f1af520564a1a7dfa9ef74ef5f0d0bf0d5
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.38e-051904643a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ELF3 NRXN3 EFEMP1 PRDM16

4.38e-05190464c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.38e-05190464e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LTBP2 EFEMP1 CILP

4.38e-05190464d13fd234caa3fc69d8a59bc0060cdacdf716ee55
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.38e-05190464b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP4 CACHD1 EFEMP1 PRDM16

4.38e-051904641c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.47e-051914645c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

ELF3 CACHD1 MALRD1 PRDM16

4.47e-05191464d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 ELF3 NRXN3 TRIM2

4.47e-051914649032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 LTBP2 EFEMP1 CILP

4.47e-051914644e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELF3 CACHD1 PRDM16 SMYD3

4.47e-05191464e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.47e-05191464094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LTBP2 TRIM2 MALRD1 PRDM16

4.47e-05191464963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCellE17.5-Epithelial-epithelial_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ELF3 WDR45 SERPINB9 TRIM2

4.47e-0519146468b717fce7d9349ef56255ee0c5e57fc67e50fd8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 ELF3 NRXN3 TRIM2

4.47e-051914645717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.47e-05191464997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.47e-05191464ba02cbdfda6a94374a6472eb88499059979af472
ToppCellfacs-Lung-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 LRP4 EFEMP1 PRDM6

4.56e-051924648df15085b35b86f39debd933284cb703c5dd63c2
ToppCellCOVID-19-lung-Secretory|COVID-19 / Disease (COVID-19 only), tissue and cell type

ELF3 MUC5B CACHD1 MUC5AC

4.56e-0519246459261098ccb52306f837f632ebaea45b90ad30fe
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

ELF3 CACHD1 TRIM2 PRDM16

4.56e-05192464d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LTBP2 NRXN3 PRDM6 PROS1

4.56e-0519246493903576dddd8227328e4ced75aa7625eedb9baf
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 LRP4 EFEMP1 PRDM6

4.56e-051924645876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELF3 TRIM2 EFEMP1 COL26A1

4.65e-051934640499611c21d283321ef6dd24add154dea48da1b7
ToppCellClub_cells|World / lung cells shred on cell class, cell subclass, sample id

ELF3 MUC5B TRIM2 MUC5AC

4.65e-051934649d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

ELF3 NRXN3 TRIM2 PRDM16

4.65e-051934642bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LTBP2 NRXN3 PRDM6 PROS1

4.65e-05193464cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

LRP1 LTBP2 EFEMP1 CILP

4.75e-05194464d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ELF3 MUC5B TRIM2 MUC5AC

4.75e-05194464e0228f593c3493175962a4817500d4337ddc4e88
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ELF3 MUC5B TRIM2 KRT38

4.84e-05195464fc2a1d84b3d013e5cb9e7b9cdd740e4010897d20
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LTBP2 NRXN3 PRDM6 PROS1

4.84e-05195464b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PAPPA2 LTBP2 PRDM6 PROS1

4.84e-051954642514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCellE17.5-Mesenchymal-myocytic_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LTBP2 NRXN3 PRDM6 PROS1

4.84e-0519546401a750d660993017af00736215cbcff2de5909c1
DrugOxybenzone [131-57-7]; Up 200; 17.6uM; PC3; HT_HG-U133A

PAPPA2 ELF3 LTBP2 NRXN3 CILP MUC5AC

2.46e-061984566309_UP
DiseaseAbdominal Migraine

LRP1 TGFBR2 PRDM16

2.41e-079433C0270858
DiseaseSick Headaches

LRP1 TGFBR2 PRDM16

2.41e-079433C0700438
DiseaseAcute Confusional Migraine

LRP1 TGFBR2 PRDM16

2.41e-079433C0521664
DiseaseStatus Migrainosus

LRP1 TGFBR2 PRDM16

2.41e-079433C0338489
DiseaseCervical Migraine Syndrome

LRP1 TGFBR2 PRDM16

2.41e-079433C0007852
DiseaseHemicrania migraine

LRP1 TGFBR2 PRDM16

2.41e-079433C0018984
DiseaseMigraine Disorders

LRP1 TGFBR2 PRDM16

8.16e-0713433C0149931
Diseasesevere acute respiratory syndrome, COVID-19

TGFBR2 EYS LTBP2 MALRD1 PRDM6 TG

4.43e-05447436EFO_0000694, MONDO_0100096
Diseaseresponse to cranial radiation therapy, short-term memory

CACHD1 NRXN3 MALRD1

9.31e-0560433EFO_0004335, EFO_0010950
Diseasepancreatic ductal carcinoma (is_marker_for)

TGFBR2 MUC5B MUC5AC

9.78e-0561433DOID:3587 (is_marker_for)
DiseaseMarfan Syndrome

TGFBR2 LTBP2

1.13e-0411432C0024796
Diseasepulmonary fibrosis

MUC5B MUC5AC

1.13e-0411432EFO_0009448
Diseasesusceptibility to pneumonia measurement

MUC5B MALRD1 MUC5AC

3.86e-0497433EFO_0008410
DiseaseAntimigraine preparation use measurement

LRP1 PRDM16

4.28e-0421432EFO_0009939
DiseaseWest Syndrome

TSC1 WDR45

5.61e-0424432C0037769
Diseasepulse pressure measurement

LRP1 PAPPA2 LTBP2 EFEMP1 MALRD1 MED13L PRDM16 PRDM6

7.97e-041392438EFO_0005763
Diseaseintraocular pressure measurement

LRP4 LTBP2 EFEMP1 COL26A1 PRDM16

8.40e-04509435EFO_0004695
Diseaseelectrocardiography

TRIM2 CILP PRDM16 PRDM6 SMYD3

1.01e-03530435EFO_0004327
Diseasejoint hypermobility measurement

TUT4 EFEMP1

1.06e-0333432EFO_0007905
Diseaseobese body mass index status

HIPK3 PRDM6

1.06e-0333432EFO_0007041
DiseaseCOVID-19 symptoms measurement

MUC5B MUC5AC

1.20e-0335432EFO_0600019
Diseasenitric oxide exhalation measurement

PAPPA2 SMYD3

1.41e-0338432EFO_0005536

Protein segments in the cluster

PeptideGeneStartEntry
ETCDSLAFCACSMVD

CACHD1

941

Q5VU97
DFSRCDMDGATLCNC

ELF3

91

P78545
PDCMCDTFDQCAENI

CCDC180

1406

Q9P1Z9
MCCAVSEQRLTCADQ

DMAC2L

1

Q99766
SNCMFDTCNCERSED

MUC5B

646

Q9HC84
RNFDSCCICACNMNI

MED13L

1126

Q71F56
CSEEINECDSDPCMN

EYS

806

Q5T1H1
AMSCSEELQCCQSEI

KRT37

306

O76014
STCDDREFMCQNRQC

LRP1

2816

Q07954
DMSCSEELQCCQSEI

KRT38

306

O76015
TTCQEDSCANQGVCM

NRXN3

1051

Q9Y4C0
NCMFDTCNCERSEDC

MUC5AC

656

P98088
TVGMDCQECTCEAAT

MUC5AC

5291

P98088
CACDQTAAECMTSAS

OC90

391

Q02509
CEACQSTLNIDRMCS

HIPK3

896

Q9H422
GDCVECMACSDNTVR

MPI

281

P34949
SQYQSCCSCMCDEDN

FAM170B

86

A6NMN3
NNRCDMCADNRNGEC

PRDM6

196

Q9NQX0
DCMDFQLDESSCSEC

MALRD1

2011

Q5VYJ5
ECNNMLNDFDDGDCC

PAPPA2

631

Q9BXP8
ISDTCCSVLNCTDDM

DNAH1

626

Q9P2D7
EQSCVNCGREAMSEC

DEAF1

501

O75398
CIDIDECANDTMCGS

LTBP2

1301

Q14767
AVESGCAMCEREQCD

AGA

56

P20933
QETCNETTSCQMTNC

KRTAP27-1

51

Q3LI81
QMTNCEQDLFTDDSC

KRTAP27-1

61

Q3LI81
LMFRCSASCCEDSQA

FAM136A

31

Q96C01
FTGSNCDEECMNCTR

COL26A1

121

Q96A83
CDEECMNCTRLSDMS

COL26A1

126

Q96A83
HSRNDCSCNCDMDCS

MDFIC2

151

A0A1B0GVS7
NECETTNECREDEMC

EFEMP1

336

Q12805
CSCDDQNLTMCQISE

PRDM16

176

Q9HAZ2
ETFFMCSCSSDECND

TGFBR2

131

P37173
CICANMSVSRLSCDD

OR56A3

181

Q8NH54
SLRFNQDQSCFCCAM

WDR45

11

Q9Y484
QDQSCFCCAMETGVR

WDR45

16

Q9Y484
CEDIDECSENMCAQL

PROS1

241

P07225
CDCFRCQTQDKDADM

SMYD3

261

Q9H7B4
QVNADCDACMCQDFM

CILP

211

O75339
ERLDCCNDGCSDSMV

TSC1

991

Q92574
AASSCFVVAECCMES

SERPINB9

331

P50453
VCQCHEDFMSEDCSE

TNN

216

Q9UQP3
ESDCCVAMASSCSAV

TRAF6

16

Q9Y4K3
QVSCDNCAASMAFED

TRAF6

186

Q9Y4K3
NECEAIMEHCSDCFD

TEX15

1791

Q9BXT5
QSCETAMCRECTEGE

TRIM2

131

Q9C040
AMSSERIACQFCEQD

MID2

131

Q9UJV3
CDEMDCTSQRCIIDN

TUT4

766

Q5TAX3
MQCLTDCTEDEACSF

TG

1601

P01266
MQEDCEKGFQCCSSF

WFDC13

51

Q8IUB5
CDDQSDERNCTTSMC

LRP4

256

O75096
DERNCTTSMCTAEQF

LRP4

261

O75096