Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

GMPR2 GMPR

6.30e-0521592GO:0046857
GeneOntologyMolecularFunctionGMP reductase activity

GMPR2 GMPR

6.30e-0521592GO:0003920
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DAB2IP DENND5B RASA2 OBSCN ADGRB3 RCBTB2 RGS11 DENND2B SLIT2 DENND6A ARHGAP28 RAPGEF2 PREX1

2.17e-0450715913GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DAB2IP DENND5B RASA2 OBSCN ADGRB3 RCBTB2 RGS11 DENND2B SLIT2 DENND6A ARHGAP28 RAPGEF2 PREX1

2.17e-0450715913GO:0030695
GeneOntologyMolecularFunctionmitogen-activated protein kinase kinase binding

DAB2IP KSR2 ACE

4.37e-04191593GO:0031434
GeneOntologyMolecularFunctionphospholipid binding

DAB2IP CPNE8 RASA2 OBSCN SMURF1 ARFIP1 SYT7 SH3YL1 KCNJ2 NISCH RAPGEF2 PREX1 EPB41

4.55e-0454815913GO:0005543
GeneOntologyMolecularFunctioncytoskeletal protein binding

KIF18A CENPF OBSCN FHOD3 CLSTN2 MAP10 ACE KIF20B DST BAIAP2L1 GLI1 NISCH SYNE2 MYH15 AATF DCLK2 SSH2 CAMSAP2 EPB41 ADSS1

4.72e-04109915920GO:0008092
GeneOntologyMolecularFunctioncalmodulin binding

OBSCN GRM4 ACE SYT7 IQCB1 MYH15 CAMSAP2 EPB41

5.24e-042301598GO:0005516
GeneOntologyBiologicalProcesspurine ribonucleotide salvage

GMPR2 HPRT1 GMPR ADSS1

5.62e-06161584GO:0106380
GeneOntologyBiologicalProcesspurine nucleotide salvage

GMPR2 HPRT1 GMPR ADSS1

1.17e-05191584GO:0032261
GeneOntologyBiologicalProcesspurine-containing compound salvage

GMPR2 HPRT1 GMPR ADSS1

2.18e-05221584GO:0043101
GeneOntologyBiologicalProcesspurine ribonucleoside monophosphate biosynthetic process

GMPR2 HPRT1 GMPR ADSS1

2.62e-05231584GO:0009168
GeneOntologyBiologicalProcessIMP metabolic process

GMPR2 HPRT1 GMPR ADSS1

3.13e-05241584GO:0046040
GeneOntologyBiologicalProcessIMP salvage

GMPR2 HPRT1 GMPR

3.58e-0591583GO:0032264
GeneOntologyBiologicalProcessnucleoside monophosphate biosynthetic process

GMPR2 TK1 HPRT1 GMPR ADSS1

3.60e-05491585GO:0009124
GeneOntologyBiologicalProcesspurine nucleoside monophosphate biosynthetic process

GMPR2 HPRT1 GMPR ADSS1

3.70e-05251584GO:0009127
GeneOntologyBiologicalProcessnucleotide salvage

GMPR2 HPRT1 GMPR ADSS1

4.35e-05261584GO:0043173
GeneOntologyBiologicalProcessdendrite development

DAB2IP ADGRB3 CSMD3 BTBD3 SH3GLB1 HPRT1 NLGN2 CTNND2 RAPGEF2 CAMSAP2 PREX1

5.67e-0533515811GO:0016358
GeneOntologyBiologicalProcessliver regeneration

PNPT1 SULF2 GLI1 PRMT5

1.29e-04341584GO:0097421
GeneOntologyBiologicalProcessregulation of dendrite development

DAB2IP ADGRB3 CSMD3 SH3GLB1 RAPGEF2 CAMSAP2 PREX1

1.59e-041501587GO:0050773
GeneOntologyBiologicalProcesschemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

SLIT2 SLIT3

1.74e-0431582GO:0021834
GeneOntologyBiologicalProcessIMP biosynthetic process

GMPR2 HPRT1 GMPR

1.88e-04151583GO:0006188
GeneOntologyBiologicalProcessribonucleoside monophosphate biosynthetic process

GMPR2 HPRT1 GMPR ADSS1

2.00e-04381584GO:0009156
GeneOntologyBiologicalProcesstelencephalon cell migration

DAB2IP SLIT2 GLI3 SYNE2 SLIT3

2.29e-04721585GO:0022029
GeneOntologyBiologicalProcesscellular metabolic compound salvage

GMPR2 HPRT1 GMPR ADSS1

2.44e-04401584GO:0043094
GeneOntologyBiologicalProcessforebrain cell migration

DAB2IP SLIT2 GLI3 SYNE2 SLIT3

2.77e-04751585GO:0021885
GeneOntologyCellularComponentGMP reductase complex

GMPR2 GMPR

5.75e-0521592GO:1902560
GeneOntologyCellularComponentcell-cell contact zone

AKAP6 OBSCN JAM2 JUP DST KCNJ2

8.26e-05941596GO:0044291
GeneOntologyCellularComponentintercalated disc

AKAP6 OBSCN JUP DST KCNJ2

1.69e-04681595GO:0014704
GeneOntologyCellularComponentmitotic spindle midzone

KIF18A MAP10 KIF20B

2.25e-04161593GO:1990023
GeneOntologyCellularComponentGLI-SUFU complex

GLI1 GLI3

3.42e-0441592GO:1990788
GeneOntologyCellularComponentsarcolemma

AKAP6 OBSCN LAMP1 DST KCNJ2 AGRN VCAM1

6.40e-041901597GO:0042383
GeneOntologyCellularComponenthost intracellular region

GBP7 GBP4

8.45e-0461592GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP7 GBP4

8.45e-0461592GO:0030430
GeneOntologyCellularComponenthost cell part

GBP7 GBP4

8.45e-0461592GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP7 GBP4

8.45e-0461592GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP7 GBP4

8.45e-0461592GO:0033655
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP7 GBP4

8.45e-0461592GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP7 GBP4

8.45e-0461592GO:0020005
GeneOntologyCellularComponentZ disc

OBSCN FHOD3 JUP DST SYNE2 ASB2

1.06e-031511596GO:0030018
GeneOntologyCellularComponentI band

OBSCN FHOD3 JUP DST SYNE2 ASB2

1.72e-031661596GO:0031674
GeneOntologyCellularComponentcell-cell junction

AKAP6 OBSCN EVPL JAM2 JUP DST BAIAP2L1 KCNJ2 SSX2IP CTNND2 RAPGEF2 CDH13

1.92e-0359115912GO:0005911
GeneOntologyCellularComponentperinuclear region of cytoplasm

AKAP6 GTPBP4 NCOA3 RASA2 GBP7 CENPF LAMP1 HRNR KIF20B DST GBP4 CCAR1 RAPGEF2 PREX1 CDH13 SPINK5

2.07e-0393415916GO:0048471
DomainGMPR

GMPR2 GMPR

7.20e-0521592IPR005993
DomainC2

DAB2IP CPNE8 RASA2 SMURF1 SYT7 FER1L6 TC2N

1.31e-041311597PF00168
DomainSPEC

AKAP6 EVPL DST SYNE2

1.51e-04321594SM00150
DomainSpectrin/alpha-actinin

AKAP6 EVPL DST SYNE2

1.51e-04321594IPR018159
DomainC2

DAB2IP CPNE8 RASA2 SMURF1 SYT7 FER1L6 TC2N

1.73e-041371597SM00239
DomainC2

DAB2IP CPNE8 RASA2 SMURF1 SYT7 FER1L6 TC2N

2.16e-041421597PS50004
Domain-

DAB2IP CPNE8 RASA2 SMURF1 SYT7 FER1L6 TC2N

2.78e-0414815972.60.40.150
Domain-

GTF2IRD2B GTF2IRD2

4.27e-04415923.90.1460.10
DomainIMPDH

GMPR2 GMPR

4.27e-0441592PF00478
DomainIMP_DH_GMPRt

GMPR2 GMPR

4.27e-0441592IPR001093
DomainIMP_DH_GMP_RED

GMPR2 GMPR

4.27e-0441592PS00487
DomainIMP_DH/GMP_Rdtase_CS

GMPR2 GMPR

4.27e-0441592IPR015875
DomainGTF2I

GTF2IRD2B GTF2IRD2

4.27e-0441592PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

4.27e-0441592PF02946
DomainGTF2I

GTF2IRD2B GTF2IRD2

4.27e-0441592IPR004212
DomainC2_dom

DAB2IP CPNE8 RASA2 SMURF1 SYT7 FER1L6 TC2N

5.17e-041641597IPR000008
PathwayREACTOME_NUCLEOTIDE_SALVAGE

GMPR2 TK1 HPRT1 GMPR

3.65e-05231184MM15552
PathwayREACTOME_NUCLEOTIDE_SALVAGE

GMPR2 TK1 HPRT1 GMPR

3.65e-05231184M27831
PathwayREACTOME_PURINE_SALVAGE

GMPR2 HPRT1 GMPR

1.54e-04131183M814
PathwayREACTOME_PURINE_SALVAGE

GMPR2 HPRT1 GMPR

1.54e-04131183MM15438
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

AKAP6 DAB2IP ZBTB6 ATRX RASA2 GBP7 OBSCN SMURF1 HIPK2 ARFIP1 ZNF568 ERLIN1 KMT2C JUP GBP4 GLI1 GRAMD2B AATF TASOR AGRN RAD17

3.05e-0810841602111544199
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DAB2IP GTPBP4 NCOA3 CENPF KSR2 ADGRB3 GRM4 DST NISCH SYNE2 CCAR1 NLGN2 SSH2 CTNND2 RAPGEF2 CAMSAP2 AGRN RAI1

5.34e-079631601828671696
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

DAB2IP TEX15 HRNR ARFIP1 BTBD3 JUP DST MKI67 HADHA TDRD6

8.72e-072841601029459677
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

GTPBP4 CPNE8 DDX17 CENPF HRNR ERLIN1 SLIT2 CRNKL1 JUP DST ATAD3A PRMT5 HPRT1 SYNE2 AHCY MKI67 AATF HADHA

1.28e-0610241601824711643
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

GTPBP4 CPNE8 DDX17 CENPF EVPL HRNR NDUFB10 KIF20B ERLIN1 CRNKL1 JUP DST BAIAP2L1 ATAD3A PRMT5 AHCY MKI67 AATF HADHA TBL2

1.47e-0612571602036526897
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

GTPBP4 DDX17 TEX15 HRNR FER1L6 SLIT2 DST CCAR1 UTY

1.51e-06234160936243803
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DENND2B JUP DST MAST4 BAIAP2L1 PRMT5 SYNE2 IQCB1 SSX2IP DCLK2 SSH2 MORC3 RAPGEF2 MAP3K21 CAMSAP2 EPB41

2.56e-068611601636931259
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

DNAH10 PGM3 DST ATAD3A PRMT5 SYNE2 ANKRD36 SSH2

2.67e-06187160826460568
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

DDX17 ATRX CENPF SPG11 RGS11 ERLIN1 FER1L6 GTF2IRD2B DST ANTXR2 ATAD3A SYNE2 GTF2IRD2 CCAR1 MYH15 AATF HADHA CAMSAP2 TASOR PREX1 RAI1

3.17e-0614421602135575683
Pubmed

Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line.

GLI1 GLI3 MKI67

3.30e-067160328799057
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

FNDC3B ATRX SYT7 KIF20B GGCX ERLIN1 KMT2C CRNKL1 DST PRMT5 CCAR1 WDR89 AATF DGCR8 CTNND2 CAMSAP2 TASOR AGRN PREX1 TBL2 EPB41

5.64e-0614971602131527615
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AKAP6 ATRX ADGRB3 HUNK BRWD3 SH3YL1 CRNKL1 DST NISCH AHCY CCAR1 ASTN1 DCLK2 ANKRD36 DGCR8 MORC3 CTNND2 RAPGEF2 PREX1

7.83e-0612851601935914814
Pubmed

miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis.

PIWIL1 ODF1 ACE

7.87e-069160312062093
Pubmed

Gli3 null mice display glandular overgrowth of the developing stomach.

GLI1 GLI3 MKI67

7.87e-069160316247775
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

NCOA3 DDX17 ATRX HIPK2 KMT2C CRNKL1 CCAR1 MORC3

8.83e-06220160835785414
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 DAB2IP ADGRB3 KMT2C SULF2 DST SYNE2 PREX1

1.04e-05225160812168954
Pubmed

Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis.

GLI1 GLI3 MKI67

1.12e-0510160338358805
Pubmed

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

PIWIL1 PRMT5 TDRD6

1.12e-0510160319584108
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GTPBP4 CENPF PNPT1 CRNKL1 DST ATAD3A PRMT5 SYNE2 MKI67 CCAR1 AATF HADHA RAI1

1.13e-056531601322586326
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

DDX17 MUC16 HRNR ARFIP1 BTBD3 DENND6A DST BAIAP2L1 GLI3 MKI67 DGCR8 RAPGEF2 TASOR EPB41

1.57e-057771601435844135
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BDP1 EPHA6 ATRX RASA2 KSR2 OBSCN SMURF1 HIPK2 DENND2B BRWD3 SH3YL1 KMT2C ATAD3A CCAR1 NLGN2 DCLK2 RAPGEF2 EPB41 RAI1 ADSS1

1.79e-0514891602028611215
Pubmed

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.

GLI1 GLI3 MKI67

2.04e-0512160318582859
Pubmed

The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase.

GBP7 GBP4

2.10e-052160221142871
Pubmed

Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.

GLI1 GLI3

2.10e-052160218559511
Pubmed

Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.

GLI1 GLI3

2.10e-052160212351188
Pubmed

A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.

GLI1 GLI3

2.10e-052160221921029
Pubmed

Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.

KIF20B GLI1

2.10e-052160229573464
Pubmed

TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes.

PRMT5 TDRD6

2.10e-052160228263986
Pubmed

Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).

GLI1 GLI3

2.10e-05216029918099
Pubmed

Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.

GLI1 GLI3

2.10e-052160232114096
Pubmed

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

GLI1 GLI3

2.10e-052160210693759
Pubmed

piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis.

PIWIL1 TDRD6

2.10e-052160238491008
Pubmed

Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes.

TK1 HPRT1

2.10e-052160210462721
Pubmed

Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.

GBP7 GBP4

2.10e-052160237621179
Pubmed

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.

GLI1 GLI3

2.10e-05216028364225
Pubmed

Dystonin deficiency reduces taste buds and fungiform papillae in the anterior part of the tongue.

SULF2 DST

2.10e-052160217156752
Pubmed

Smurf1 regulation of DAB2IP controls cell proliferation and migration.

DAB2IP SMURF1

2.10e-052160227036023
Pubmed

Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker.

TK1 MKI67

2.10e-052160228651488
Pubmed

Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.

GLI1 GLI3

2.10e-052160225103784
Pubmed

Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice.

LAMP1 SYT7

2.10e-052160212925704
Pubmed

Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators.

GMPR2 GMPR

2.10e-0521602218932
Pubmed

Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.

DAB2IP SMURF1

2.10e-052160230672020
Pubmed

Expression of cell proliferating genes in patients with non-small cell lung cancer by immunohistochemistry and cDNA profiling.

TK1 MKI67

2.10e-052160215809747
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

2.10e-052160215388857
Pubmed

Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells.

GBP7 GBP4

2.10e-05216029659399
Pubmed

NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.

GMPR2 GMPR

2.10e-052160212009299
Pubmed

Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.

GLI1 GLI3 MKI67

2.64e-0513160334210780
Pubmed

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development.

GLI1 GLI3 MKI67

2.64e-0513160334887903
Pubmed

Sufu and Kif7 in limb patterning and development.

GLI1 GLI3 MKI67

3.35e-0514160325581370
Pubmed

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

DAB2IP GTPBP4 PIWIL1 AHCY

3.46e-0540160420308539
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

DDX17 ATRX NDUFB10 KIF20B CRNKL1 JUP ATAD3A MKI67 CCAR1 AATF DGCR8 ZCCHC7 TASOR EPB41 RAI1

3.75e-059541601536373674
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DAB2IP NCOA3 KIF18A DDX17 ATRX ECHDC1 ERLIN1 PGM3 SLIT2 SH3GLB1 WDCP GLI3 HPRT1 NISCH IQCB1 MORC3 MAP3K21 CAMSAP2

4.03e-0513211601827173435
Pubmed

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

LAMP1 GLI1 GLI3

4.17e-0515160322340494
Pubmed

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.

PIWIL1 ODF1 TDRD6

4.17e-0515160325762440
Pubmed

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.

GLI1 GLI3 MKI67

4.17e-0515160326439735
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NCOA3 RASA2 MUC16 ZNF568 FER1L6 SYNE2 AATF CTNND2 PREX1 UTY TBL2 RAI1

4.29e-056381601231182584
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GTPBP4 FNDC3B DDX17 RASA2 THUMPD3 KIF20B ERLIN1 CRNKL1 JUP DST ATAD3A TK1 AHCY MKI67 CCAR1 AATF HADHA AGRN

5.49e-0513531601829467282
Pubmed

Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.

SLIT2 SLIT3

6.29e-053160210102269
Pubmed

Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.

GLI1 GLI3

6.29e-053160226010061
Pubmed

Predicting Lymph Node Metastasis in Endometrial Cancer Using Serum CA125 Combined with Immunohistochemical Markers PR and Ki67, and a Comparison with Other Prediction Models.

MUC16 MKI67

6.29e-053160227163153
Pubmed

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

SLIT2 SLIT3

6.29e-05316029813312
Pubmed

Function of Slit/Robo signaling in breast cancer.

SLIT2 SLIT3

6.29e-053160226542734
Pubmed

Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.

SLIT2 SLIT3

6.29e-053160216840550
Pubmed

Brachyphalangy, an allele of extra-toes in the mouse.

GLI1 GLI3

6.29e-05316025806166
Pubmed

CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes.

HPRT1 UTY

6.29e-053160234862376
Pubmed

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.

GLI1 GLI3

6.29e-053160228965847
Pubmed

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.

SLIT2 SULF2

6.29e-053160229062064
Pubmed

Gli family members are differentially expressed during the mitotic phase of spermatogenesis.

GLI1 GLI3

6.29e-05316029178901
Pubmed

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.

GLI1 GLI3

6.29e-05316028378770
Pubmed

The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.

JUP DST

6.29e-053160231425296
Pubmed

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.

SLIT2 SLIT3

6.29e-053160224065825
Pubmed

Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.

SLIT2 SLIT3

6.29e-053160216162649
Pubmed

Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.

GLI1 GLI3

6.29e-053160224311597
Pubmed

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation.

HIPK2 AATF

6.29e-053160225210797
Pubmed

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.

GLI1 GLI3

6.29e-053160210075717
Pubmed

DNA topoisomerase IIα and mitosin expression predict meningioma recurrence better than histopathological grade and MIB-1 after initial surgery.

CENPF MKI67

6.29e-053160228301542
Pubmed

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.

GLI1 GLI3

6.29e-05316028387379
Pubmed

Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.

GLI1 GLI3

6.29e-053160216571352
Pubmed

The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.

GLI1 GLI3

6.29e-053160229722127
Pubmed

Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

SLIT2 SLIT3

6.29e-053160210349621
Pubmed

Conserved modularity and potential for alternate splicing in mouse and human Slit genes.

SLIT2 SLIT3

6.29e-053160212141424
Pubmed

Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.

GLI1 GLI3

6.29e-053160222178118
Pubmed

[Expression of HER2/neu in meningiomas: an immunohistochemistry and fluorescence in situ hybridization study].

TK1 MKI67

6.29e-053160220450760
Pubmed

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

GBP7 GBP4

6.29e-053160235780181
Pubmed

Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma.

CENPF MKI67

6.29e-053160220398247
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

6.29e-053160215100712
Pubmed

UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells.

PIWIL1 PRMT5

6.29e-053160231624244
Pubmed

Common variation in GPC5 is associated with acquired nephrotic syndrome.

SULF2 PREX1

6.29e-053160221441931
Pubmed

GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.

GBP7 GBP4

6.29e-053160229128363
Pubmed

The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer.

KLK10 MUC16

6.29e-053160220680316
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

DDX17 HRNR JUP PRMT5 HADHA

6.54e-0591160534445801
Pubmed

A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.

GTPBP4 NCOA3 CLCA4 RGS11 CCAR1 TASOR EPB41

7.15e-05218160719460752
Pubmed

The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.

SLIT2 GLI1 SLIT3

7.41e-0518160316854408
Pubmed

Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.

ATRX GLI1 GLI3

7.41e-0518160314645126
Pubmed

Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.

GLI1 GLI3 MKI67

7.41e-0518160319570847
Pubmed

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.

GLI1 GLI3 MKI67

8.77e-0519160332234482
Pubmed

APC sets the Wnt tone necessary for cerebral cortical progenitor development.

GLI1 GLI3 MKI67

8.77e-0519160328916710
Pubmed

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.

GLI1 GLI3 MKI67

8.77e-0519160325848030
Pubmed

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.

GLI1 GLI3 MKI67

8.77e-0519160324886827
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

DST ATAD3A SYNE2 CCAR1 RAD17

9.31e-0598160534943047
CytobandEnsembl 112 genes in cytogenetic band chr1p22

CLCA4 GBP7 SH3GLB1 GBP4 SSX2IP

1.25e-041371605chr1p22
Cytoband3p14.3

DENND6A TASOR DNASE1L3

1.57e-043016033p14.3
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND5B DENND2B DENND6A

3.99e-04251053504
GeneFamilyEF-hand domain containing|Plakins

EVPL DST

9.14e-0481052939
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

DAB2IP RASA2

1.46e-03101052830
CoexpressionGSE11961_MARGINAL_ZONE_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN

IL10RA KRT26 GBP7 DENND2B KIF20B ANTXR2 GBP4 SSX2IP ASB2 RAPGEF2

4.25e-0720015910M9321
CoexpressionGSE411_WT_VS_SOCS3_KO_MACROPHAGE_IL6_STIM_400MIN_UP

COQ10B ERLIN1 BAIAP2L1 TK1 GRAMD2B MKI67 ASB2 RAPGEF2 DNASE1L3

3.88e-062001599M5994
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

BDP1 KIF18A ECHDC1 THUMPD3 HIPK2 SPG11 ZNF397 KIF20B SULF2 SYNE2 MKI67 CCAR1 CTNND2 TASOR RAD17

1.18e-0565615915M18979
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

BDP1 KIF18A ATRX CENPF KIF20B JAM2 GLI3 SYNE2 CCAR1

1.34e-051921579Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#4

BDP1 ATRX CENPF KIF20B SYNE2 MKI67 CCAR1 ASTN1 EPB41

1.34e-051921579Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

BDP1 GTPBP4 KIF18A ATRX CENPF ECHDC1 KIF20B GLI3 SYNE2 MKI67 CCAR1

2.09e-0531115711Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlaskidney_e10.5_UretericTip_HoxB7_top-relative-expression-ranked_1000

GTPBP4 ZBTB6 CENPF THUMPD3 RCBTB2 FHOD3 KIF20B BRWD3 SH3YL1 SLIT2 PNPT1 MEX3A INSL6 SSX2IP AATF SSH2 CTNND2 MAP3K21

2.19e-0578715718gudmap_kidney_e10.5_UretericTip_HoxB7_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

KIF18A KLK10 EPHA6 ATRX CENPF KSR2 HIPK2 FHOD3 CLSTN2 KIF20B SLIT2 WDCP GLI3 SYNE2 SSX2IP MKI67 TIGD3 CCAR1 ASTN1 CTNND2 EPB41

3.69e-05106015721facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000

DENND5B ATRX CENPF ADGRB3 HIPK2 FHOD3 ZKSCAN2 CLSTN2 KIF20B JAM2 SLIT2 KCNJ2 SYNE2 SLIT3 CCAR1 ASTN1 DCLK2 CTNND2 EPB41 VCAM1

4.13e-0598615720Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

BDP1 KIF18A ATRX CENPF ARFIP1 KIF20B DST GLI3 CCAR1 MORC3 RAPGEF2 PREX1 EPB41

4.78e-0546915713Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#3_top-relative-expression-ranked_1000

NCOA3 ATRX HIPK2 WDCP CAMSAP2 AGRN

5.89e-05911576DevelopingKidney_e15.5_Endothelial cells_emap-29977_k3_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5

BDP1 CENPF FHOD3 KIF20B JAM2 GLI3 SYNE2 ASTN1 CTNND2

5.92e-052321579Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500

KIF18A KLK10 EPHA6 ATRX CENPF KSR2 HIPK2 FHOD3 CLSTN2 GRM4 KIF20B JAM2 SLIT2 WDCP GLI3 SYNE2 SSX2IP MKI67 TIGD3 CCAR1 ASTN1 CTNND2 EPB41 VCAM1

1.14e-04141415724facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

DENND5B BDP1 GTPBP4 KIF18A ATRX CENPF ECHDC1 ADGRB3 FHOD3 ZKSCAN2 KIF20B JAM2 SLIT2 GLI3 SYNE2 MKI67 CCAR1 ASTN1 CTNND2

1.33e-0498915719Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

DENND5B KIF18A ATRX CENPF ECHDC1 HIPK2 ZNF397 GRM4 KIF20B BRWD3 SLIT2 SULF2 TRMT44 INSL6 KCNJ2 WDCP GLI3 SYNE2 MKI67 CCAR1 PREX1 EPB41

1.39e-04125215722facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#4_top-relative-expression-ranked_1000

KHNYN RCBTB2 CLSTN2 HUNK SYT7 CRNKL1 NLGN2

1.99e-041611577gudmap_developingKidney_e11.5_metaneph mesench_1000_k4
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX RGS11 SYT7 KMT2C DST NISCH GMPR ZCCHC7 UTY

3.84e-0819516097796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX RGS11 SYT7 KMT2C DST NISCH GMPR ZCCHC7 UTY

3.84e-0819516093e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 CSMD3 SLIT2 DST MAST4 GLI3 SLIT3 ARHGAP28 VCAM1

4.20e-0819716090034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 JUP SULF2 C2 ASB2 CTNND2 DNASE1L3 VCAM1

1.93e-071701608670027daec5a10dfa12246f1497b58db21d32a22
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

CENPF GNLY ODF1 ANGPTL2 TC2N SYNE2 MKI67 VCAM1

2.02e-071711608dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

AKAP6 ADGRB3 CSMD3 SLIT2 DST GLI3 SLIT3 ARHGAP28

4.32e-071891608203c80030df08ae112f9ae4043709f455d87ce89
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DENND5B FNDC3B FHOD3 SLIT2 MAST4 SYNE2 SSH2 RAPGEF2

4.87e-071921608e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TEX15 CSMD3 SLIT2 ANTXR2 MAST4 GLI3 ARHGAP28 VCAM1

5.27e-07194160899577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TEX15 CSMD3 SLIT2 ANTXR2 MAST4 GLI3 ARHGAP28 VCAM1

5.48e-07195160870387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 SLIT2 DST MAST4 GLI3 SLIT3 ARHGAP28 VCAM1

5.92e-07197160831a1852911bda38543916585fda34255fd62a134
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 SLIT2 DST MAST4 GLI3 SLIT3 ARHGAP28 VCAM1

5.92e-07197160811a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellFibroblasts-HLA-DRA_high_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SIX1 DENND2B SLIT2 SULF2 ANGPTL2 GLI3 NLGN2 VCAM1

6.15e-071981608e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 DDX17 ATRX TC2N SYNE2 ANKRD36 UTY EPB41

6.39e-071991608f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCA4 GBP7 SIX1 DENND2B MAST4 GBP4 HAS3 SPINK5

6.63e-0720016080f6620a5baace704518d42fa2f3f90751240f7dd
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

ADGRB3 MUC16 TEX15 CSMD3 RAB41 CTNND2 CDH13

7.26e-07139160764c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 JUP C2 ASB2 CTNND2 DNASE1L3 VCAM1

2.68e-0616916073f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 JUP C2 ASB2 CTNND2 DNASE1L3 VCAM1

2.68e-06169160726de495c7562e0740689d0f78e803698e3e793db
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC1|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CLSTN2 ACE DST GRAMD2B ASB2 CTNND2 DNASE1L3

2.68e-061691607488ba50631a64cb9e0d69219491c66ac824c9e7d
ToppCellfacs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B FNDC3B HRNR DCST1 GGCX INSL6 C2

2.68e-061691607b798b91567d2f49082e2d8a337169f241c8d2080
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 JUP SULF2 DST C2 ASB2 VCAM1

3.64e-06177160726bad614560609d318bfc9c235a698bca4e1c22c
ToppCellPBMC-Mild-cDC_11|Mild / Compartment, Disease Groups and Clusters

RGS11 CLSTN2 DENND2B GLI1 ASB2 DNASE1L3 VCAM1

3.64e-061771607974305e4c0eff90134c4e58cf11b955d1eee0501
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB2IP KLK10 EVPL SYT7 JAM2 DST CDH13

3.92e-061791607a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CPNE8 JAM2 SULF2 MAST4 SYNE2 RAPGEF2 CDH13

3.92e-0617916072a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OBSCN FHOD3 RGS11 CLSTN2 DENND2B CTNND2 CDH13

3.92e-061791607a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

STAB2 ACE BTBD3 JAM2 JUP KCNJ2 DCLK2

4.37e-061821607fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAB2IP KLK10 EVPL SYT7 JAM2 DST CDH13

4.70e-0618416078bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

CLSTN2 DST KCNJ2 MYH15 DCLK2 ASB2 DNASE1L3

4.70e-061841607ee295f6fa898da53883e1358b17f2c2dd177e9a7
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAB2IP KLK10 EVPL SYT7 JAM2 DST CDH13

4.70e-061841607f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE SYT7 JAM2 DST AGRN CDH13 VCAM1

5.04e-0618616079c7924875f70420720149287c500b4dfa8d24673
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE SYT7 JAM2 DST AGRN CDH13 VCAM1

5.23e-06187160712129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EVPL ACE ATP6AP1L JAM2 DST CDH13 VCAM1

5.23e-0618716077170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

AKAP6 SLIT2 DST SLIT3 ARHGAP28 DCLK2 CDH13

5.23e-061871607464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACE SYT7 JAM2 DST AGRN CDH13 VCAM1

5.23e-06187160783930ef55191eff9006113feaeabb3c2fa21fd05
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

FNDC3B EPHA6 ADGRB3 SLIT2 TC2N GRAMD2B SSH2

5.80e-06190160712992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCOA3 GRM4 BTBD3 SLIT2 ANTXR2 MAST4 GRAMD2B

5.80e-0619016071bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

RASA2 CENPF GNLY TC2N SYNE2 MKI67 EPB41

6.00e-0619116077f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

AKAP6 OBSCN FHOD3 DST MAST4 CTNND2 CDH13

6.00e-06191160725f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCA4 CENPF GRM4 JUP TK1 MKI67 HAS3

6.00e-0619116070f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

FNDC3B EPHA6 ADGRB3 CLSTN2 SLIT2 TC2N SSH2

6.00e-06191160770c067c54084bfb02c29bab085f4defd477194fb
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCOA3 GRM4 BTBD3 JAM2 SLIT2 ANTXR2 MAST4

6.21e-06192160725460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DNAH10 KSR2 CLSTN2 HRNR CSMD3 ZNF17 ARHGAP28

6.43e-061931607088c8b1e968f5356502347eaabdc6b1b1d4befd0
ToppCellSevere_COVID-19-Myeloid-proliferating_Myeloid_cells|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.43e-0619316070d85025690c9cd545cba30abc38acbdd6a39b153
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

FNDC3B EPHA6 ADGRB3 CLSTN2 SLIT2 TC2N SSH2

6.65e-06194160711c79a8c56ece42713b04b321982e41e239f07a5
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-0619416072360b5f995b360419de41612368cab9fb61781a1
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-061941607903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CPNE8 ACE GBP4 KCNJ2 PREX1 DNASE1L3 CDH13

6.65e-0619416072e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-061941607cb39850e9577015b6b9834e98c36b412bae7d462
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-061941607408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-061941607193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CENPF ADGRB3 KIF20B DST TK1 SLIT3 MKI67

6.65e-06194160758406502a8cbcc3037f79a1b6a683df408297ae5
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

DDX17 OBSCN MAST4 TC2N SYNE2 ANKRD36 EPB41

6.87e-0619516074bdedd924564a260841a9153604026b57487c83d
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 SLIT2 DST MAST4 SLIT3 ARHGAP28 VCAM1

6.87e-0619516071cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

CFAP95 DNAH10 ODAD4 FHAD1 FAM227A SPATS1 BBOX1

6.87e-06195160760067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 SLIT2 DST MAST4 GLI3 SLIT3 ARHGAP28

7.11e-0619616071450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CENPF TEX15 KIF20B JAM2 TK1 MKI67 VCAM1

7.35e-06197160776b61e60a757e58b465569538e632d6d9953e89a
ToppCellTransverse-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

DAB2IP FNDC3B MUC16 DCST1 FHAD1 HAS3 ADSS1

7.35e-061971607a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KLK10 CENPF HUNK KIF20B TK1 MKI67 MYH15

7.35e-0619716070a6754a5109bec0d0de42adbfdf4db43ff60c3d2
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AKAP6 DNAH10 ODAD4 CLSTN2 FHAD1 SYNE2 FAM227A

7.35e-06197160774a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLCA4 KLK10 JUP DST MAST4 GRAMD2B HAS3

7.59e-06198160777517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

ADGRB3 SLIT2 DST GLI3 SLIT3 ARHGAP28 CDH13

7.59e-061981607df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGRB3 SLIT2 DST MAST4 GLI3 SLIT3 ARHGAP28

7.59e-06198160717dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CENPF JUP GBP4 TK1 SYNE2 MKI67 ZCCHC7

7.85e-0619916078e7f9312dec1e3a92b6a0ccc7baa2d46e89c11f3
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

FNDC3B ADGRB3 KMT2C SSH2 ZCCHC7 RAPGEF2 UTY

7.85e-06199160794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

CENPF KIF20B SLIT2 DST TK1 MKI67 VCAM1

7.85e-0619916077ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KIF18A CENPF MEIOB KIF20B TK1 SYNE2 MKI67

7.85e-061991607be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 DDX17 ATRX KMT2C JUP SYNE2 EPB41

8.11e-06200160712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 FHOD3 CLSTN2 SLIT3 DCLK2 ASB2 CDH13

8.11e-062001607a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ATRX ACE SYT7 DST MAST4 SYNE2 DCLK2

8.11e-062001607a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellNon-neuronal-Dividing-IPC|World / Primary Cells by Cluster

KIF18A CENPF KIF20B TK1 GLI3 SYNE2 MKI67

8.11e-062001607971533181daa1bfac1f1b8c507d2013f891f9078
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD8-positive,_alpha-beta_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 KIF20B ANGPTL2 GLI1 MORC3 UTY

9.88e-0613616069d7080f695de4ef183e3dbdc18ba464a3b8e3469
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

DDX17 HUNK KMT2C SYNE2 ANKRD36 UTY

2.15e-0515616061545169694f686d28648a68b552c2ae606599d66
ToppCell368C-Myeloid-Dendritic-cDC1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DENND5B HRNR IQCB1 DCLK2 ASB2 DNASE1L3

2.57e-0516116061011094c54381d52566e24c92f89f2efc2aa3eea
ToppCellCOVID-19_Severe-multiplets|World / disease group, cell group and cell class

CENPF RGS11 GNLY TEX15 TK1 MKI67

2.76e-0516316066db4271c2d47a9c333964f36d2c32207115e52cd
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

CLCA4 STAB2 ACE ANTXR2 GBP4 DCLK2

2.76e-051631606d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCellfacs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF18A SYT7 ZNF568 ZNF8 TRMT44 AGRN

2.85e-0516416061d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF18A SYT7 ZNF568 ZNF8 TRMT44 AGRN

2.85e-051641606bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA ACE ZNF8 ANGPTL2 RAPGEF2 UTY

2.85e-051641606b77995958c938e10a526118f75d78cee72e0b207
ToppCellDividing_Macrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

KIF18A ATRX CENPF KIF20B TK1 MKI67

3.06e-051661606c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

KLK10 MUC16 SLIT2 ANGPTL2 SLIT3 VCAM1

3.06e-0516616061ed3788257e14f097862b999f020bfe2a57de52b
ToppCell356C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CFAP95 HIPK2 MYH15 ASB2 DNASE1L3 VCAM1

3.06e-051661606971ee6602a1e751f453f9d823295e63dadce62bf
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AKAP6 GBP7 JAM2 FAM227A CDH13 VCAM1

3.16e-051671606774f3264318b002d0df5d06d41d645366038d0bf
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA SMURF1 ACE FHAD1 C2 SSH2

3.27e-051681606e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF18A KRT26 CENPF PIWIL1 KIF20B MKI67

3.38e-051691606e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCST1 JAM2 SLIT3 ASTN1 NLGN2 CDH13

3.49e-0517016068fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF18A STAB2 CENPF KIF20B TK1 MKI67

3.49e-051701606b04e2f84024baaae9b4ff19bdac8c69afdb92a76
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCST1 JAM2 SLIT3 ASTN1 NLGN2 CDH13

3.49e-0517016063232db50b1a40f861e981a1b9c9073b81af9f832
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCST1 JAM2 SLIT3 ASTN1 NLGN2 CDH13

3.49e-05170160650c6c571591aa4b218caefe5778c570c809f567e
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA OBSCN ACE SSH2 VCAM1 ADSS1

3.61e-051711606355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX DENND6A DST KCNJ2 SSH2 TASOR

3.85e-051731606869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 STAB2 ERLIN1 ASB2 RAPGEF2 ADSS1

3.85e-05173160620f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KLK10 MUC16 FHOD3 HUNK FER1L6 GRAMD2B

3.85e-051731606464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX DENND6A DST KCNJ2 SSH2 TASOR

3.85e-0517316060672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX DENND6A DST KCNJ2 SSH2 TASOR

3.85e-051731606870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPNE8 CLSTN2 TEX15 GRM4 TC2N SLIT3

4.10e-05175160690e29945aa861082c94bb4f331161adc3a6ef899
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF18A CENPF KIF20B BTBD3 ZNF667 MKI67

4.10e-05175160615c69dd5635c9251c535f1e22467712e9667ae92
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB3 CSMD3 WDR89 MYH15 ANKRD36 DNASE1L3

4.10e-051751606887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF KIF20B TK1 SLIT3 MKI67 TIGD3

4.24e-05176160645c6983ab671b0f306e7390320bd84f848e474cc
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DENND5B ACE ANTXR2 GBP4 IQCB1 ARHGAP28

4.37e-0517716066da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KLK10 MUC16 SIX1 GRM4 TC2N GRAMD2B

4.37e-051771606a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellEndothelial-Endothelial-C|Endothelial / shred on cell class and cell subclass (v4)

COQ10B ACE SYT7 JAM2 MAST4 MYH15

4.37e-051771606b5b9278dfd76b1aacd88e5fe86e91a2c9b565f87
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

FNDC3B ATRX HIPK2 KMT2C DST

6.80e-0549955GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED
DrugHPPR -MP

GMPR2 HPRT1 GMPR ADSS1

3.49e-0861604CID000086479
Drugthiopurinol

GMPR2 HPRT1 GMPR ADSS1

2.23e-06141604CID000667510
Drug1-nitrosopyrene

GMPR2 TK1 HPRT1 GMPR

3.02e-06151604CID000104777
Drug6-mercaptopurine monohydrate; Down 200; 10uM; PC3; HG-U133A

KIF18A HIPK2 SIX1 ARFIP1 MAST4 PLEKHO2 SSX2IP RAPGEF2 UTY

1.02e-051951609667_DN
Drugestradiol, USP; Down 200; 0.01uM; PC3; HG-U133A

HIPK2 SIX1 ARFIP1 MAST4 PLEKHO2 SSX2IP AGRN UTY CARD14

1.25e-052001609665_DN
Drugroxarsone

GMPR2 GLI3 HPRT1 GMPR

2.65e-05251604CID000005104
Drug1-nitropyren-6-ol

GMPR2 HPRT1 GMPR

3.94e-05101603CID000104988
DrugACVDP

PNPT1 HPRT1 ADSS1

3.94e-05101603CID000501523
DrugAC1LAQAP

GMPR2 GMPR ADSS1

3.94e-05101603CID000493157
Drug1-nitropyren-8-ol

GMPR2 HPRT1 GMPR

3.94e-05101603CID000105022
Drug3-nitrofluoranthen-6-ol

GMPR2 GMPR

4.91e-0521602CID000146572
Drug3-nitrofluoranthen-9-ol

GMPR2 GMPR

4.91e-0521602CID000146573
Drug3-nitrofluoranthen-8-ol

GMPR2 GMPR

4.91e-0521602CID000146567
Drug1,3,6-trinitropyrene

GMPR2 GMPR

4.91e-0521602CID000053229
DrugAC1L25J4

GMPR2 GMPR

4.91e-0521602CID000041328
Drug2-methylcarbazole

GMPR2 GMPR

4.91e-0521602CID000019290
Drugm-nitrobenzamidine hydrochloride

GMPR2 GMPR

4.91e-0521602CID000165122
Drug2-hydroxypropyl

CLSTN2 C2

4.91e-0521602CID000141483
Drug2-nitrobenzofuran

GMPR2 GMPR

4.91e-0521602CID000036328
Drug1,3,6,8-tetranitropyrene

GMPR2 GMPR

4.91e-0521602CID000034321
DiseaseLiver carcinoma

KIF18A STAB2 CENPF ACE SLIT2 PNPT1 KMT2C TK1 GLI1 MKI67 DNASE1L3 CDH13 VCAM1

2.63e-0650715313C2239176
Diseasevisceral adipose tissue measurement, body mass index

DNAH10 KSR2 CLSTN2 GRAMD2B DCLK2

9.21e-05871535EFO_0004340, EFO_0004765
DiseaseAtrial Fibrillation

AKAP6 DNAH10 ACE KCNJ2 SYNE2 SLIT3

1.94e-041601536C0004238
Diseasevon Willebrand factor measurement

DAB2IP STAB2 TC2N C2

2.07e-04561534EFO_0004629
DiseaseIGF-1 measurement

DENND5B FNDC3B STAB2 EPHA6 RASA2 MEIOB INSL6 SYNE2 SLIT3 ASTN1

2.44e-0448815310EFO_0004627
Diseasecongenital diaphragmatic hernia (biomarker_via_orthology)

ACE SLIT2 SLIT3

2.55e-04241533DOID:3827 (biomarker_via_orthology)
Diseaseinterstitial cystitis (is_marker_for)

MKI67 VCAM1

2.64e-0451532DOID:13949 (is_marker_for)
DiseaseColorectal Carcinoma

AKAP6 OBSCN CLSTN2 CSMD3 KMT2C TK1 GLI3 MKI67 CCAR1 CTNND2 CAMSAP2 DNASE1L3

3.13e-0470215312C0009402
Diseaseblood rubidium measurement

INSL6 PREX1 CDH13

3.26e-04261533EFO_0021529
Diseaseunipolar depression, depressive symptom measurement

KSR2 ZKSCAN2 PREX1

3.26e-04261533EFO_0003761, EFO_0007006
DiseaseCarcinoma, Granular Cell

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0205644
DiseaseAdenocarcinoma, Tubular

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0205645
DiseaseAdenocarcinoma, Oxyphilic

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0205642
DiseaseCarcinoma, Cribriform

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0205643
DiseaseAdenocarcinoma, Basal Cell

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0205641
DiseaseAdenocarcinoma

NCOA3 GMPR2 ACE KMT2C MKI67

3.54e-041161535C0001418
DiseaseSubstance abuse problem

PIWIL1 FHOD3 CSMD3 ASTN1 CDH13

3.54e-041161535C0740858
Diseasefactor VIII measurement, von Willebrand factor measurement

DAB2IP STAB2 TC2N

3.65e-04271533EFO_0004629, EFO_0004630
DiseaseProstatic Neoplasms

DAB2IP NCOA3 STAB2 CENPF ACE KMT2C JUP ANTXR2 ATAD3A CDH13 SPINK5

3.87e-0461615311C0033578
DiseaseMalignant neoplasm of prostate

DAB2IP NCOA3 STAB2 CENPF ACE KMT2C JUP ANTXR2 ATAD3A CDH13 SPINK5

3.87e-0461615311C0376358
Diseaseubiquitin-like protein ISG15 measurement

C2 AGRN

3.95e-0461532EFO_0021875
Diseasealcohol consumption measurement

AKAP6 CPNE8 RASA2 ADGRB3 CSMD3 ERLIN1 BTBD3 MAST4 GLI3 FAM227A AATF ANKRD36 CTNND2 HAS3 AGRN CDH13

7.53e-04124215316EFO_0007878
Diseaseprimary bacterial infectious disease (implicated_via_orthology)

GLI1 GLI3

9.39e-0491532DOID:0050338 (implicated_via_orthology)
DiseaseParoxysmal atrial fibrillation

AKAP6 DNAH10 ACE SYNE2 SLIT3

1.35e-031561535C0235480
Diseasefamilial atrial fibrillation

AKAP6 DNAH10 ACE SYNE2 SLIT3

1.35e-031561535C3468561
DiseasePersistent atrial fibrillation

AKAP6 DNAH10 ACE SYNE2 SLIT3

1.35e-031561535C2585653
Diseasepars orbitalis volume measurement

CFAP95 SLIT2

1.42e-03111532EFO_0010320
Diseasesuicide behaviour measurement

MKI67 ZCCHC7 CTNND2

1.45e-03431533EFO_0006882
DiseaseMalignant neoplasm of breast

AKAP6 NCOA3 FNDC3B KLK10 CENPF OBSCN ATP6AP1L SULF2 GLI1 WDCP NISCH SYNE2 MKI67 DNASE1L3

1.45e-03107415314C0006142
DiseaseGastrointestinal Stromal Sarcoma

HIPK2 GLI1 GLI3

1.88e-03471533C3179349
Diseasesystemic lupus erythematosus (is_marker_for)

MKI67 C2 VCAM1

1.88e-03471533DOID:9074 (is_marker_for)
Diseasehigh density lipoprotein particle size measurement

DNAH10 SULF2 BAIAP2L1 NISCH RAI1

1.97e-031701535EFO_0008592
Diseasemiddle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement

KSR2 MAP3K21

2.01e-03131532EFO_0006514, EFO_0010316
DiseaseGastrointestinal Stromal Tumors

HIPK2 GLI1 GLI3

2.24e-03501533C0238198
Diseaseprecuneus cortex volume measurement

CFAP95 CDH13

2.33e-03141532EFO_0010326
Diseasediacylglycerol 42:7 measurement

SYNE2 WDR89

2.33e-03141532EFO_0020068
Diseasecognitive function measurement, self reported educational attainment

AKAP6 CLSTN2 SYT7 ATP6AP1L ERLIN1 MYH15 PREX1

2.61e-033551537EFO_0004784, EFO_0008354
Diseasemonoclonal gammopathy

KSR2 PREX1 CDH13

2.65e-03531533EFO_0000203
Diseaseidiopathic scoliosis (implicated_via_orthology)

DNAH10 PRMT5

3.06e-03161532DOID:0060250 (implicated_via_orthology)
DiseaseDrug habituation

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0013170
DiseaseDrug abuse

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0013146
DiseasePrescription Drug Abuse

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C4316881
DiseaseSubstance-Related Disorders

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0236969
DiseaseDrug Use Disorders

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0013222
DiseaseDrug Dependence

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C1510472
DiseaseSubstance Dependence

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0038580
DiseaseSubstance Use Disorders

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

PIWIL1 FHOD3 CSMD3 CDH13

3.08e-031151534C0029231
Diseaseovarian cancer (is_implicated_in)

MUC16 JUP CDH13

3.10e-03561533DOID:2394 (is_implicated_in)
DiseaseHypertrophic Cardiomyopathy

OBSCN FHOD3 ATAD3A

3.26e-03571533C0007194
Diseasepre-malignant neoplasm (biomarker_via_orthology)

GLI1 GLI3

3.45e-03171532DOID:0060071 (biomarker_via_orthology)
Diseasesphingomyelin 14:0 measurement

SYNE2 WDR89

3.45e-03171532EFO_0010390
Diseaselevel of Sphingomyelin (d32:1) in blood serum

SYNE2 WDR89

3.45e-03171532OBA_2045173
Diseasehippocampal tail volume

ATP6AP1L MAST4

4.31e-03191532EFO_0009398
Diseaseend stage renal disease (implicated_via_orthology)

GTPBP4 ACE

4.77e-03201532DOID:783 (implicated_via_orthology)
Diseasebrain connectivity measurement

ATP6AP1L SLIT2 ANTXR2 GLI3 DCLK2 SSH2 HAS3

4.99e-034001537EFO_0005210

Protein segments in the cluster

PeptideGeneStartEntry
RQRKSQYSCKGSELR

FAM227A

101

F5H4B4
CSSGLLVYKDKLRIN

EPB41

416

P11171
TSTKEKQPCSDRYRI

BDP1

131

A6H8Y1
KQASCSGDEYRSLKV

PGM3

196

O95394
RLVGKSSAVCRKSSY

CSMD3

2601

Q7Z407
QCDIYRSTKAGAKLR

ACE

556

P12821
KKENSELRRTVYLCT

ADGRB3

1271

O60242
RESCFYRKLTDTSKD

CCAR1

971

Q8IX12
SCYSKLKEQLETSRR

SSX2IP

136

Q9Y2D8
SNKSRETPLYKACER

ASB2

201

Q96Q27
SDVISKRSGYCKTRL

COQ10B

111

Q9H8M1
RLKLAQFDYGRKCSE

ATAD3A

551

Q9NVI7
SCALKYSDIRTGRES

ERLIN1

311

O75477
KKCTNRERIGQDSAY

GRM4

386

Q14833
DSLYRCKQLKRAALG

GTPBP4

121

Q9BZE4
LKKARCESQRGLYVA

AGRN

731

O00468
YKCTRQIISEKLGRG

ARFIP1

136

P53367
KEAKISRSLGASVYC

ANTXR2

161

P58335
GRQSLLRDAKDCKST

BRWD3

101

Q6RI45
SCGSAEYSAKIELKR

BTBD3

416

Q9Y2F9
LNRYKRAGESQDKCT

ANGPTL2

41

Q9UKU9
KRNGETLAKTIACYS

ANKRD36

1556

A6QL64
SDCKGNDKLRYEVSS

CDH13

56

P55290
ESCRSKDRKVLYTGA

DGCR8

126

Q8WYQ5
DRETYSEKSLQKLCG

CLSTN2

311

Q9H4D0
SCYSVDRGKRKTGTL

DENND2B

306

P78524
LSDSKKRSLYDRAGC

DNAJB8

56

Q8NHS0
ISLKERKTDYECTGS

CTNND2

1081

Q9UQB3
KNFRCISDRKLDSTG

ASTN1

621

O14525
RLDSLNGKKIACLSY

RCBTB2

91

O95199
AGLSCDRQRLLAKDY

RAI1

36

Q7Z5J4
RLKYISSCKRLRSDS

RAI1

1576

Q7Z5J4
SKTDDLGSLRLNICY

RASA2

301

Q15283
GKILYCKRASLTELD

RAD17

401

O75943
AERTEYQSLCKSKLL

RAB41

21

Q5JT25
NIRKRGTLVDYEKDC

RGS11

131

O94810
IYCNLLDGEERKSKS

KRT26

386

Q7Z3Y9
CSARDLAEKKYILSN

KCNJ2

356

P63252
KKLCNSTYRRLGTDE

CFAP95

71

Q5VTT2
KYFTTSDRRKGQRCE

MEIOB

181

Q8N635
CLDDVLYARTTGKLK

DAB2IP

236

Q5VWQ8
LYSGCRLTSLRSEKD

MUC16

12436

Q8WXI7
EGCTKAYSRLENLKT

GLI3

551

P10071
SSSRRIQKGEELCYD

KMT2C

4871

Q8NEZ4
RRSTVSLLDTYQKCG

HIPK2

116

Q9H2X6
ISDKRTGKNSCYENI

MAP10

681

Q9P2G4
RALKKSVCSGRELYL

ECHDC1

261

Q9NTX5
LCSEYRKLVRNGKLA

SPINK5

366

Q9NQ38
LCSEYRKSRKNGRLF

SPINK5

436

Q9NQ38
LRNECSSVYSKGRIL

DST

476

Q03001
RKQYCTLKEAGLSNA

KIF18A

581

Q8NI77
DKVRYRCSSNLVLTG

C2

171

P06681
LCKGRTLYSVVRDAK

KSR2

741

Q6VAB6
GNRCSESSTLLEKYK

DCLK2

381

Q8N568
CLVRSKYNDDIRKGI

FIS1

41

Q9Y3D6
RQLDKCSIERDQYKS

MORC3

821

Q14149
RKSGKQYSIEAALRC

EVPL

1741

Q92817
GAYSSARKCLAKQRQ

NDUFB10

141

O96000
LTKTQELGRDYRTCL

GNLY

56

P22749
KDYCQVSGSKLRDDT

HRNR

91

Q86YZ3
KRALSELTQGVTCYK

KIF20B

1146

Q96Q89
ASAKYCQAELKRLSE

GBP4

416

Q96PP9
ASAKYCQAELKRLSE

GBP7

401

Q8N8V2
EGCRKSYSRLENLKT

GLI1

306

P08151
YLRQTRCAEEKATKT

IL10RA

446

Q13651
CTYVGAAKLKELSRR

GMPR2

316

Q9P2T1
IKNVTRSDAGKYRCE

JAM2

96

P57087
CRKSGLQTDYATEKE

MKI67

261

P46013
SAERENRYDCLGSKK

ODF1

151

Q14990
CFREAAYTKRLGTEK

TK1

156

P04183
DEACGRQYTLKKTTT

JUP

46

P14923
RLKSYCNDQSTGDIK

HPRT1

101

P00492
LKILFCKQSDRGLYT

OBSCN

296

Q5VST9
RYSLRQDGTKCELQI

OBSCN

3581

Q5VST9
LAGCVQRKDYTALTK

ATRX

1811

P46100
GSLTKCRQIYEEANK

CRNKL1

726

Q9BZJ0
KGYSKVLCQTLSERN

FHAD1

311

B1AJZ9
RSNVVRKDYDTLSKC

BAIAP2L1

266

Q9UHR4
CLSVKVNTDGYKRLL

CARD14

651

Q9BXL6
KKSTNCAYDRIVLRG

DNASE1L3

226

Q13609
QTYREKLTSKEECLS

CENPF

2726

P49454
STYFCQIDDRRKKLG

DCST1

411

Q5T197
YTGEDLTCTVKNLKR

FNDC3B

526

Q53EP0
CIEKLYNSSGRDLRR

FHOD3

111

Q2V2M9
GKSDIQDSLCYKTRL

HUNK

391

P57058
SDCYLDSAKARKLLV

BBOX1

41

O75936
LRTSIYQKCSTLKEA

DENND5B

606

Q6ZUT9
SKLTDREKTNICYLS

DENND6A

86

Q8IWF6
SSSKLYNEVRACREK

PRMT5

476

O14744
DRRAEGKKCTEALYA

MAST4

2366

O15021
CQYRIATKDRKTVLG

HADHA

156

P40939
STCYKGLRRLLSKQE

IQCB1

251

Q15051
ENASRAKEYLKGLCS

KHNYN

61

O15037
RADIDKKYRCVSGTQ

LAMP1

146

P11279
SLGYRTKYTARSKCL

HAS3

326

O00219
GNTTRRCLLEGYDTK

FAM102B

111

Q5T8I3
SGKTNLRRCTYLVLD

DDX17

311

Q92841
CTYVGAAKLKELSRR

GMPR

316

P36959
KGLRKYLLGSSDTEC

GTF2IRD2

491

Q86UP8
KGLRKYLLGSSDTEC

GTF2IRD2B

491

Q6EKJ0
LSRDSTYKLLKSVCG

GRAMD2B

201

Q96HH9
YDRGKELNCKSIRDL

DNAH10

2551

Q8IVF4
DTSECYTDSGRKRKR

EFCAB3

416

Q8N7B9
KSKFDNLYGCRESLI

AHCY

186

P23526
KYTRLLAAKVGCDRE

NLGN2

306

Q8NFZ4
YCRAGSLILKSDAAK

CAMSAP2

81

Q08AD1
SVRALCNGDYDRTIK

CPNE8

216

Q86YQ8
DTGGRKDLTYSVICK

EPHA6

356

Q9UF33
VVCLLSSNRKDKYDA

PIWIL1

556

Q96J94
DIRTGTKGYLKCDIS

FER1L6

191

Q2WGJ9
CQRKLGKRYKNSLET

SYT7

41

O43581
TKTLLGKAVRCYESL

UTY

66

O14607
VDEKRTQYIKSRRGC

TRMT44

516

Q8IYL2
YECESKNKVGSQLRS

VCAM1

666

P19320
YSSKAARTGLRICDL

ADSS1

171

Q8N142
VDYGRKELVSCSSLR

TDRD6

346

O60522
AVCRSKSLKAGLDYN

SYNE2

4621

Q8WXH0
KRLYGSVCDLRTNKL

TC2N

151

Q8N9U0
RKKTESALYGCTVLL

MAP3K21

716

Q5TCX8
ISSARKLCGRYLVKE

INSL6

26

Q9Y581
TRAKANAEKLCTLYE

MYH15

1251

Q9Y2K3
YLQDGDKNCLVARSK

ODAD4

41

Q96NG3
CSGEKRRREQESKYI

NCOA3

31

Q9Y6Q9
GSCLIERKETNRKFY

SH3YL1

166

Q96HL8
NLLVYCKRKSRVTGS

PREX1

296

Q8TCU6
LKECSGSRKARVLYD

SH3GLB1

301

Q9Y371
ETSYCFKEKSRGVLR

SIX1

126

Q15475
YKRCDGRDLTSLRNV

PNPT1

356

Q8TCS8
SRLKDTGYQRLDLCK

SMURF1

106

Q9HCE7
KGKLLCYISLRSATR

TASOR

366

Q9UK61
DTDKRYCGKTTSRKA

AATF

66

Q9NY61
KEISSSLGRLNDCYK

AKAP6

476

Q13023
SLGRLNDCYKEKSRL

AKAP6

481

Q13023
LSRACRIDSTTKLYG

CLCA4

206

Q14CN2
RSKRRKYVFQCTDGS

SLIT3

1491

O75094
KLSISYLRECAKAND

SPG11

1356

Q96JI7
SGTLKTALLDYIKRC

SPG11

2196

Q96JI7
SKCGKAYSRSSSLIR

ZNF667

586

Q5HYK9
SLCKKYSRETSQILE

RNF212

71

Q495C1
YIDDLFKLRSKTSCA

RAPGEF2

741

Q9Y4G8
KRESKYSGIDEALLC

TIGD3

71

Q6B0B8
SSLDRKYLDGLDVCR

GGCX

86

P38435
LLRYEKGCVREKQSN

ZNF568

191

Q3ZCX4
RSASLAKLGYLDLCK

SSH2

1256

Q76I76
LGNKRSLSERTVDKC

SPATS1

171

Q496A3
CALYKEAELRLKGSS

MEX3A

116

A1L020
RLSGCTAKVKQYREE

ARHGAP28

421

Q9P2N2
LDFTCRLKYLKVSGT

NISCH

181

Q9Y2I1
GTKSLGNEKRRCIYT

STAB2

1296

Q8WWQ8
RSKRRKYSFECTDGS

SLIT2

1496

O94813
GSSCKISRDRGKIYF

THUMPD3

61

Q9BV44
KSLGKRDLYDEAERC

ZNF397

251

Q8NF99
QGYKTLRLRENCVLS

ZNF8

171

P17098
DEDSIYRCKGKNVRV

ZCCHC7

96

Q8N3Z6
QSTDPSKYRKRECIS

ZKSCAN2

696

Q63HK3
GSYEKCQDLRALLKR

PLEKHO2

66

Q8TD55
LCSNGSIRIYDKERL

WDR89

46

Q96FK6
YGRKRRLTSQDSSEC

TEX15

941

Q9BXT5
EGNSLICLRKKDYLT

WDCP

296

Q9H6R7
ICLRKKDYLTGTGQD

WDCP

301

Q9H6R7
KELLRSQGAECYKLR

ATP6AP1L

201

Q52LC2
CDSGDYKLSLAGRRK

SULF2

506

Q8IWU5
ERVYSNTKKIGRCIS

TGM6

411

O95932
NGKYLATCADDRTIR

TBL2

101

Q9Y4P3
SECGKLFRYNSDLIK

ZNF17

221

P17021
LSCYTGALEVKRKEL

ZBTB6

86

Q15916
TTAARRVKYNKGLTC

KLK10

176

O43240