Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	5.81e-05	5	51	2	GO:1990508
Domain	-	VAPA CFAP221	1.95e-04	8	50	2	2.60.40.360
Domain	PapD-like	VAPA CFAP221	2.50e-04	9	50	2	IPR008962
Domain	A1pp	MACROD1 PARP14	2.50e-04	9	50	2	SM00506
Domain	Macro	MACROD1 PARP14	2.50e-04	9	50	2	PF01661
Domain	Macro_dom	MACROD1 PARP14	3.12e-04	10	50	2	IPR002589
Domain	MACRO	MACROD1 PARP14	3.12e-04	10	50	2	PS51154
Domain	SANT	ZKSCAN2 MIER1 DNAJC2	3.24e-04	50	50	3	SM00717
Domain	SANT/Myb	ZKSCAN2 MIER1 DNAJC2	3.64e-04	52	50	3	IPR001005
Domain	-	HSP90B1 SACS	1.29e-03	20	50	2	3.30.565.10
Domain	HATPase_C	HSP90B1 SACS	1.43e-03	21	50	2	IPR003594
Domain	SANT_dom	MIER1 DNAJC2	2.19e-03	26	50	2	IPR017884
Domain	SANT	MIER1 DNAJC2	2.54e-03	28	50	2	PS51293
Domain	Myb_DNA-binding	MIER1 DNAJC2	3.95e-03	35	50	2	PF00249
Domain	MYB_LIKE	MIER1 DNAJC2	4.64e-03	38	50	2	PS50090
Domain	DnaJ	SACS DNAJC2	7.62e-03	49	50	2	SM00271
Domain	DNAJ_1	SACS DNAJC2	7.62e-03	49	50	2	PS00636
Domain	DNAJ_2	SACS DNAJC2	7.62e-03	49	50	2	PS50076
Domain	-	SACS DNAJC2	7.62e-03	49	50	2	1.10.287.110
Pathway	WP_COVID19_STRUCTURAL_COVERAGE_MAP	MACROD1 PARP14 AQR	3.82e-05	26	36	3	M48318
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	VAPA USP5 HSP90B1 MYCBP2 SYTL4 RRN3 POLA1 YLPM1 CBX1 USP37 CNOT1 AQR NUP205	1.56e-09	1005	51	13	19615732
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	NDUFA13 HSP90B1 AFAP1 MAP2 MYCBP2 SACS YLPM1 CBX1 CNOT1 AQR NUP205	3.83e-07	1082	51	11	38697112
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	2.11e-06	2	51	2	26416749
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	2.11e-06	2	51	2	32560467
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	2.11e-06	2	51	2	28855340
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	2.11e-06	2	51	2	35181333
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	2.11e-06	2	51	2	30585107
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	2.11e-06	2	51	2	27678455
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	2.11e-06	2	51	2	31044597
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	2.11e-06	2	51	2	36006697
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	2.11e-06	2	51	2	20408451
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	2.11e-06	2	51	2	37378433
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	2.11e-06	2	51	2	22117896
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP5 MYCBP2 POLA1 YLPM1 CNOT1 AQR ESF1 NUP205	4.63e-06	653	51	8	22586326
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	6.32e-06	3	51	2	26002960
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	6.32e-06	3	51	2	28151579
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	MYCBP2 YLPM1 CNOT1 AQR NUP205	1.19e-05	202	51	5	24639526
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	1.26e-05	4	51	2	29440396
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	1.26e-05	4	51	2	32439758
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EEF1B2 HSP90B1 MYCBP2 SACS YLPM1 CBX1 CNOT1 AQR NUP205	1.61e-05	1024	51	9	24711643
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PASK SYNJ1 MYCBP2 CDK19 ALPK1	2.00e-05	225	51	5	12168954
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 CDK19	2.10e-05	5	51	2	36545778
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NDUFA13 EEF1B2 USP5 HSP90B1 MYCBP2 MACROD1 CNOT1 MYO16	2.14e-05	807	51	8	30575818
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	EEF1B2 USP5 AFAP1 MAP2 ZNF830	3.06e-05	246	51	5	15345747
Pubmed	The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.	ZNF830 AQR	3.15e-05	6	51	2	25599396
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	4.41e-05	7	51	2	22668559
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	VAPA PASK HSP90B1 MAP2 MYCBP2 SACS SUCO AQR ESF1 DNAJC2	5.10e-05	1487	51	10	33957083
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 CDK19	5.87e-05	8	51	2	23749998
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 CDK19	5.87e-05	8	51	2	30695077
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	VAPA EEF1B2 HSP90B1 AFAP1 CBX1 AQR ESF1 DNAJC2 NUP205	7.92e-05	1257	51	9	36526897
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYCBP2 SYTL4 RRN3 POLA1 YLPM1 CBX1 CNOT1	8.60e-05	724	51	7	36232890
Pubmed	Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta.	HSP90B1 POLA1	9.42e-05	10	51	2	7654366
Pubmed	METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.	USP5 USP37	1.15e-04	11	51	2	36602428
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CDK8 TRMT44 POLA1 YLPM1 AIG1 MACROD1 CNOT1 ESF1 NUP205	1.20e-04	1327	51	9	32694731
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	CDK8 CDK19	1.38e-04	12	51	2	23563140
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EEF1B2 USP5 HSP90B1 MYCBP2 POLA1 CBX1 AQR ESF1 NUP205	1.38e-04	1353	51	9	29467282
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	POLA1 YLPM1 PARP14 AQR NUP205	1.43e-04	341	51	5	32971831
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	VAPA EEF1B2 HSP90B1 MYCBP2 YLPM1 GID8 CNOT1	1.71e-04	809	51	7	32129710
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SYNJ1 MYCBP2 YLPM1 GID8 CNOT1	1.79e-04	358	51	5	32460013
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	HSP90B1 SACS	1.90e-04	14	51	2	15082773
Pubmed	An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.	CBX1 MIER1	1.90e-04	14	51	2	28981838
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	VAPA NDUFA13 EEF1B2 USP5 HSP90B1 POLA1 GID8 AQR DNAJC2	1.94e-04	1415	51	9	28515276
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NDUFA13 EEF1B2 USP5 HSP90B1 AFAP1 SYNJ1 MAP2 SACS CNOT1	2.10e-04	1431	51	9	37142655
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	VAPA NDUFA13 USP5 SYNJ1	2.23e-04	202	51	4	33601422
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	VAPA EEF1B2 HSP90B1 SYNJ1 MAP2 MYCBP2 GID8 CNOT1	2.35e-04	1139	51	8	36417873
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP5 USP37	2.83e-04	17	51	2	23287719
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	VAPA NDUFA13 USP5 HSP90B1 SYNJ1 MAP2	2.88e-04	621	51	6	22794259
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	MYCBP2 SACS CNOT1	3.09e-04	89	51	3	36861887
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	VAPA USP5 HSP90B1 POLA1 CNOT1 NUP205	3.32e-04	638	51	6	33239621
Pubmed	RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.	EEF1B2 USP5 HSP90B1	3.40e-04	92	51	3	23055941
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	VAPA NDUFA13 CYTH3 MACROD1 CBX1 GID8 NUP205	4.00e-04	931	51	7	27432908
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNJ1 MYCBP2 MYO16	4.35e-04	100	51	3	10048485
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MYCBP2 YLPM1 AQR ESF1 NUP205	4.61e-04	440	51	5	34244565
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	USP5 HSP90B1 PARP14 NUP205	5.96e-04	262	51	4	36880596
Pubmed	High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.	ZNF830 AQR	6.19e-04	25	51	2	26627737
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EEF1B2 USP5 POLA1 YLPM1 AQR ESF1 NUP205	6.64e-04	1014	51	7	32416067
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KIF26B POLA1 PWWP3B PARP14 CNOT1 NUP205	7.05e-04	736	51	6	29676528
Pubmed	The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1.	EEF1B2 CBX1	7.78e-04	28	51	2	22234250
Pubmed	Phosphorylated tau interactome in the human Alzheimer's disease brain.	USP5 HSP90B1 MAP2	8.32e-04	125	51	3	32812023
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SYNJ1 POLA1 YLPM1 AQR ESF1	8.65e-04	506	51	5	30890647
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	VAPA USP37 CNOT1	8.91e-04	128	51	3	25332235
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PASK EEF1B2 MYCBP2 YLPM1 MIER1 ESF1	9.15e-04	774	51	6	15302935
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AFMID TMEM248 SYNJ1 SUCO CNOT1 MIER1 ESF1	9.81e-04	1084	51	7	11544199
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP5 USP37	1.02e-03	32	51	2	33669244
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	VAPA EEF1B2 HSP90B1 POLA1 CNOT1 AQR ESF1 NUP205	1.03e-03	1425	51	8	30948266
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PASK AFAP1 CNOT1 MIER1 NUP205	1.05e-03	529	51	5	14621295
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	VAPA EEF1B2 USP5 HSP90B1 AFAP1 GID8 CNOT1 NUP205	1.10e-03	1440	51	8	30833792
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	VAPA EEF1B2 HSP90B1 SACS DGKK YLPM1 ESF1 NUP205	1.11e-03	1442	51	8	35575683
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	USP5 CBX1 CNOT1 NUP205	1.18e-03	315	51	4	26777405
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	EEF1B2 USP5 HSP90B1 MAP2 POLA1 GID8 CNOT1 NUP205	1.18e-03	1455	51	8	22863883
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNJ1 MYCBP2 YLPM1 CNOT1 ESF1	1.24e-03	549	51	5	38280479
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	VAPA USP5 HSP90B1 SYNJ1 MAP2	1.27e-03	552	51	5	36293380
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	NDUFA13 USP5 DNAJC2	1.28e-03	145	51	3	28846114
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 AFMID MAP2 MYCBP2 CDK19 AIG1 MACROD1 CNOT1	1.37e-03	1489	51	8	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	VAPA NDUFA13 EEF1B2 AFAP1 CBX1 AQR ESF1 DNAJC2	1.41e-03	1497	51	8	31527615
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	TMEM248 POLA1 CNOT1 NUP205	1.42e-03	331	51	4	19490893
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CBX1 CNOT1 ESF1 NUP205	1.43e-03	332	51	4	25693804
Interaction	CDK8 interactions	CDK8 POLA1 CDK19 ZNF830 AQR ESF1 NUP205	1.37e-06	222	51	7	int:CDK8
Cytoband	13q12	CDK8 SACS	3.29e-04	24	51	2	13q12
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	ZKSCAN2 MIER1 DNAJC2	1.11e-04	53	32	3	532
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	9.61e-04	26	32	2	496
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	1.55e-03	33	32	2	1061
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SACS DNAJC2	3.39e-03	49	32	2	584
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SACS YLPM1 MYO16	3.95e-03	181	32	3	694
GeneFamily	Ubiquitin specific peptidases	USP5 USP37	4.40e-03	56	32	2	366
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	SYT15 SYCP2L KIF26B CYTH3 DGKK CDK19 YLPM1 SNX15 PWWP3B USP37	1.69e-05	834	49	10	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AFAP1 SYTL4 ALPK1 DNAI3 MYO16	3.05e-06	197	51	5	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AFAP1 MYCBP2 SYTL4 DNAI3 MYO16	3.21e-06	199	51	5	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AFAP1 SYTL4 KIF26B ALPK1 MYO16	3.28e-06	200	51	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	MYCBP2 SYTL4 ALPK1 DNAI3 MYO16	3.28e-06	200	51	5	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	HSP90B1 MYCBP2 PARP14 CNOT1 MIER1	3.28e-06	200	51	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TRMT44 SYTL4 CYTH3 USP37	1.95e-05	139	51	4	4efab4421e3448880a1dcf981f6a65131b038010
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TRMT44 SYTL4 CYTH3 USP37	1.95e-05	139	51	4	39f3c28f89c37bb8cc049c56d2948ea906fb3d86
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 CBX1 MIER1 AQR	5.82e-05	184	51	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Mild-CD4+_T\|Mild / Disease group and Cell class	PASK EEF1B2 CYTH3 MYO16	5.95e-05	185	51	4	c28ecb63146de1b02418e5a4fad0ae7c2b66a41d
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SYNJ1 MYCBP2 KIF26B PWWP3B	6.33e-05	188	51	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1 KIF26B DNAI3 MYO16	6.59e-05	190	51	4	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AFAP1 KIF26B DNAI3 MYO16	6.87e-05	192	51	4	deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell	Severe-CD4+_T\|World / Disease group and Cell class	PASK EEF1B2 AFAP1 CYTH3	7.15e-05	194	51	4	2ad888f78765ecfb8d1ea978c75c90fa3030509a
ToppCell	COVID-19-Lymphoid-CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	PASK EEF1B2 AFAP1 CYTH3	7.44e-05	196	51	4	28515d8e2f02366fa0ac1bea251a7a3f659c98c7
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	AFAP1 MYCBP2 SYTL4 MYO16	7.89e-05	199	51	4	fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts\|LPS_only / Treatment groups by lineage, cell group, cell type	AFAP1 MYCBP2 SYTL4 MYO16	7.89e-05	199	51	4	1a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell	LPS_only-Mesenchymal_fibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	AFAP1 MYCBP2 SYTL4 MYO16	7.89e-05	199	51	4	211c3a08f2d484ab7a3368006767289088f0d957
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	AFAP1 SYTL4 DNAI3 MYO16	8.04e-05	200	51	4	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	AFAP1 MAP2 KIF26B MYO16	8.04e-05	200	51	4	961858738ce35db8760c8c2e136f8369bc444ccf
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	2.70e-06	2	49	2	DOID:0112221 (implicated_via_orthology)
Disease	myeloperoxidase (MPO)-DNA complex measurement	KIF26B CDK19	6.11e-04	22	49	2	EFO_0011039
Disease	diverticular disease	VAPA AFMID AFAP1 KIF26B	6.37e-04	236	49	4	EFO_0009959
Disease	daytime rest measurement	MYCBP2 KIF26B ZSCAN9 SUCO	1.46e-03	295	49	4	EFO_0007828
Disease	diet measurement	EEF1B2 HPD KIF26B ZKSCAN2 ALPK1 CNOT1 MYO16	1.64e-03	1049	49	7	EFO_0008111
Disease	lysophosphatidylcholine 20:3 measurement	HSP90B1 RRN3	2.02e-03	40	49	2	EFO_0010362
Disease	anxiety, stress-related disorder, major depressive disorder	ZSCAN9 ZKSCAN2	2.67e-03	46	49	2	EFO_0005230, EFO_0010098, MONDO_0002009
Disease	FEV/FEC ratio	VAPA AFAP1 MAP2 SYTL4 YLPM1 ZKSCAN2 MYO16	3.96e-03	1228	49	7	EFO_0004713
Disease	brain connectivity measurement	AFAP1 MAP2 KIF26B MYO16	4.36e-03	400	49	4	EFO_0005210
Disease	triglycerides to total lipids in very large HDL percentage	RRN3 MACROD1	4.79e-03	62	49	2	EFO_0022339
Disease	free cholesterol to total lipids in large LDL percentage	RRN3 MACROD1	6.76e-03	74	49	2	EFO_0022280

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSDMEAVWKEAKPDE	VAPA	106	Q9P0L0
AVWKEAKPDELMDSK	VAPA	111	Q9P0L0
IWDTQKSMEEEKEKP	AIG1	221	Q9NVV5
FPADKDWEDIRKMPE	CDK19	261	Q9BWU1
WPSEEASMDLVKDAK	AFAP1	141	Q8N556
FWNLIKKNDEKMDPE	AQR	196	O60306
GEVIYTDWKMEKDPE	DNAI3	641	Q8IWG1
EEFPMLKTLDPKDWK	DNAJC2	71	Q99543
EKFESLKENIWMKDP	FAM200A	441	Q8TCP9
IQEAKEMKWPFVPEK	ALPK1	51	Q96QP1
SKVPWKKMSAEELEN	AFMID	11	Q63HM1
DEPDTLEAAKKTMWE	NUP205	1436	Q92621
KEFKKLSEIDWMNPI	DGKK	1186	Q5KSL6
KKEKVLEDCWIEDPK	PASK	1031	Q96RG2
KAEIAWEEKMKEPLS	MYO16	306	Q9Y6X6
MPWKEESEFTKQDKA	MFI	1	Q8NCR3
AKKEMKFEDPWLKRE	KIF26B	1431	Q2KJY2
RFWEMPEKDRKVKID	ESF1	21	Q9H501
LEEEAIIMKDVPDWK	NDUFA13	91	Q9P0J0
IIMKDVPDWKVGESV	NDUFA13	96	Q9P0J0
EEVDLEPMAAKAWDK	POLA1	261	P09884
DPTMWDTIKNDVKDD	PARP14	406	Q460N5
VEKEFEPLLNWMKDK	HSP90B1	611	P14625
VPDKADSMLTWEKEE	CCDC105	191	Q8IYK2
LWPESETEKEESKEM	CFAP119	236	A1A4V9
KPDEITKDEWMEKLN	GID8	6	Q9NWU2
MKWKNSDEADLVPAK	CBX1	136	P83916
PEEKEEWMKSIKASI	CYTH3	366	O43739
PTWKEMAKGVAVKVE	MACROD1	126	Q9BQ69
VKPWDDETDMAKLEE	EEF1B2	146	P24534
FPADKDWEDIKKMPE	CDK8	261	P49336
FVMVEDGWKLLKPEE	SACS	3796	Q9NZJ4
DYIPSEDWKKEIMVG	MIER1	171	Q8N108
PMSFKLKKELTEEWQ	CFAP221	386	Q4G0U5
KIMREPWVEQDKFGK	HPD	116	P32754
EKMEVAKPADSWELI	RTP2	16	Q5QGT7
WEDMSAEELQEFKKP	RRN3	581	Q9NYV6
EWKKMSAPKSQVEKE	SYTL4	226	Q96C24
EKYKEMVKVWPEVTD	TRMT44	311	Q8IYL2
FKIKEIKSPEMAEDW	TMEM248	41	Q9NWD8
EHWDEMLSKPKELVK	SYT15	396	Q9BQS2
PDWIKNLEEEMSLEK	SYNJ1	971	O43426
DQIMPTWIKDDKIKF	PWWP3B	621	Q5H9M0
MHKWPLKEISVDEDD	MYCBP2	351	O75592
EELKETVKEEFMPWV	CNOT1	1116	A5YKK6
EMRKPADEKLEKFWI	SYCP2L	306	Q5T4T6
SKKDPEDVKEVVVWK	SNX15	36	Q9NRS6
EDIPTFDEWKKKVME	SUCO	266	Q9UBS9
PKSKWEMDTSEAKLD	YLPM1	2041	P49750
EQKDWFIEMPTEAKK	MAP2	261	P11137
FIEMPTEAKKDEWGL	MAP2	266	P11137
PMREKDVFDDIPKWE	MAP2	291	P11137
KEDMEKLNKTWKTEP	USP37	441	Q86T82
RKVDAPKDQMDKEWD	ZNF830	261	Q96NB3
PKDQMDKEWDEFQKA	ZNF830	266	Q96NB3
MKVEKDPEWASEPIL	ZKSCAN2	21	Q63HK3
PEAWEELLTMKVEAK	ZSCAN9	16	O15535
DWVPKKLDVSIEMPE	USP5	581	P45974