Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	zinc ion binding	TCEA1 CALB1 ANPEP POLA1 BAZ1B DNAJC21 DPP3 TRIM14 TRIM52 RNF14 RNPEP TLL2 RECQL4 PAM ZMYM4	4.05e-05	891	101	15	GO:0008270
GeneOntologyBiologicalProcess	regulation of nucleus organization	SYNE1 NFE2L1	2.37e-05	2	101	2	GO:1903353
GeneOntologyBiologicalProcess	regulation of organelle organization	PDE3A SYNE1 FRMD7 OBSL1 BAZ1B RICTOR TWF2 CUL7 XRCC5 TWF1 USP10 NCAPG VILL NFE2L1 RECQL4 DIAPH1 PAM IQCJ-SCHIP1 PICK1	2.43e-05	1342	101	19	GO:0033043
GeneOntologyBiologicalProcess	DNA strand elongation involved in DNA replication	POLA1 MCM3 LIG1	4.97e-05	15	101	3	GO:0006271
GeneOntologyBiologicalProcess	glial cell projection elongation	ANO1 CSPG5	7.10e-05	3	101	2	GO:0106091
GeneOntologyBiologicalProcess	mitotic DNA replication	POLA1 MCM3 LIG1	7.37e-05	17	101	3	GO:1902969
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	FRMD7 BAZ1B TWF2 XRCC5 TWF1 USP10 PTPRG VILL RECQL4 CST2 DIAPH1 IQCJ-SCHIP1 PICK1 PCSK9	8.00e-05	864	101	14	GO:0051129
GeneOntologyBiologicalProcess	lagging strand elongation	POLA1 LIG1	1.42e-04	4	101	2	GO:0006273
GeneOntologyBiologicalProcess	negative regulation of organelle organization	FRMD7 BAZ1B TWF2 TWF1 USP10 VILL RECQL4 IQCJ-SCHIP1 PICK1	2.25e-04	421	101	9	GO:0010639
GeneOntologyBiologicalProcess	mitotic DNA replication initiation	POLA1 MCM3	2.35e-04	5	101	2	GO:1902975
GeneOntologyBiologicalProcess	nuclear cell cycle DNA replication initiation	POLA1 MCM3	2.35e-04	5	101	2	GO:1902315
GeneOntologyBiologicalProcess	cell cycle DNA replication initiation	POLA1 MCM3	2.35e-04	5	101	2	GO:1902292
GeneOntologyCellularComponent	alpha DNA polymerase:primase complex	POLA1 MCM3	2.29e-04	5	101	2	GO:0005658
GeneOntologyCellularComponent	3M complex	OBSL1 CUL7	2.29e-04	5	101	2	GO:1990393
Domain	ARM-like	STK36 SETX IPO7 PPP4R1L RICTOR CUL7 SIL1 NCAPG ARMH4	1.46e-05	270	100	9	IPR011989
Domain	Twinfilin	TWF2 TWF1	2.84e-05	2	100	2	IPR028458
Domain	OKL38_fam	OSGIN2 OSGIN1	2.84e-05	2	100	2	IPR029731
Domain	EGF_3	CRTAC1 FAT2 CNTNAP5 FBN2 PROZ NRXN2 CSPG5 TLL2	3.84e-05	235	100	8	PS50026
Domain	EGF-like_dom	CRTAC1 FAT2 CNTNAP5 FBN2 PROZ NRXN2 CSPG5 TLL2	5.77e-05	249	100	8	IPR000742
Domain	EGF_1	CRTAC1 FAT2 CNTNAP5 FBN2 PROZ NRXN2 CSPG5 TLL2	6.82e-05	255	100	8	PS00022
Domain	EGF_2	CRTAC1 FAT2 CNTNAP5 FBN2 PROZ NRXN2 CSPG5 TLL2	8.92e-05	265	100	8	PS01186
Domain	EGF	FAT2 CNTNAP5 FBN2 PROZ NRXN2 CSPG5 TLL2	2.71e-04	235	100	7	SM00181
Domain	-	TWF2 TWF1 VILL	2.78e-04	24	100	3	3.40.20.10
Domain	ADF-H/Gelsolin-like_dom	TWF2 TWF1 VILL	2.78e-04	24	100	3	IPR029006
Domain	E2F_CC-MB	E2F2 E2F3	4.20e-04	6	100	2	IPR032198
Domain	E2F_CC-MB	E2F2 E2F3	4.20e-04	6	100	2	PF16421
Domain	ARM-type_fold	STK36 IPO7 RICTOR CUL7 SIL1 NCAPG RNPEP DIAPH1	4.74e-04	339	100	8	IPR016024
Domain	EGF_CA	CRTAC1 FAT2 FBN2 PROZ TLL2	5.03e-04	122	100	5	SM00179
Domain	EGF-like_CS	CRTAC1 FAT2 FBN2 PROZ NRXN2 CSPG5 TLL2	5.09e-04	261	100	7	IPR013032
Domain	EGF-like_Ca-bd_dom	CRTAC1 FAT2 FBN2 PROZ TLL2	5.41e-04	124	100	5	IPR001881
Domain	E2F	E2F2 E2F3	7.78e-04	8	100	2	IPR015633
Domain	LAM_G_DOMAIN	FAT2 CNTNAP5 NRXN2	1.10e-03	38	100	3	PS50025
Domain	-	STK36 IPO7 RICTOR CUL7 SIL1 NCAPG	1.24e-03	222	100	6	1.25.10.10
Domain	ADF	TWF2 TWF1	1.24e-03	10	100	2	SM00102
Domain	Cofilin_ADF	TWF2 TWF1	1.24e-03	10	100	2	PF00241
Domain	ADF_H	TWF2 TWF1	1.24e-03	10	100	2	PS51263
Domain	ADF-H	TWF2 TWF1	1.24e-03	10	100	2	IPR002108
Domain	Laminin_G_2	FAT2 CNTNAP5 NRXN2	1.27e-03	40	100	3	PF02210
Domain	E2F_TDP	E2F2 E2F3	1.51e-03	11	100	2	PF02319
Domain	E2F_TDP	E2F2 E2F3	1.51e-03	11	100	2	SM01372
Domain	E2F_WHTH_DNA-bd_dom	E2F2 E2F3	1.51e-03	11	100	2	IPR003316
Domain	LamG	FAT2 CNTNAP5 NRXN2	1.68e-03	44	100	3	SM00282
Domain	Peptidase_M1	ANPEP RNPEP	1.81e-03	12	100	2	IPR001930
Domain	Peptidase_M1_N	ANPEP RNPEP	2.13e-03	13	100	2	IPR014782
Domain	Peptidase_M1	ANPEP RNPEP	2.13e-03	13	100	2	PF01433
Domain	HEAT	STK36 PPP4R1L NCAPG	2.16e-03	48	100	3	PF02985
Domain	HEAT	STK36 PPP4R1L NCAPG	3.71e-03	58	100	3	IPR000357
Domain	Laminin_G	FAT2 CNTNAP5 NRXN2	3.71e-03	58	100	3	IPR001791
Domain	EGF	FAT2 PROZ NRXN2 TLL2	4.70e-03	126	100	4	PF00008
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETX OBSL1 BAZ1B MCM3 E2F2 E2F3 TWF2 ITPRID2 CUL7 ZNF644 DIAPH1 ZMYM4 GAB1	1.91e-08	588	102	13	38580884
Pubmed	Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.	E2F2 E2F3 FBN2	2.44e-07	5	102	3	19142862
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO7 SYNE1 POLR1C BMS1 OBSL1 BAZ1B DNAJC21 RICTOR ITPRID2 XRCC5 GTF3C3 USP10 NCAPG NSFL1C ZNF644 NEURL4 VPS13B GAB1	3.07e-07	1487	102	18	33957083
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	PRPF31 NSD2 POLR1C BMS1 BAZ1B DNAJC21 YTHDC2 CUL7 XRCC5 GTF3C3 USP10 NEURL4 WDR24	3.61e-07	759	102	13	35915203
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PRPF31 IPO7 NSD2 POLA1 ACLY SYNE1 BMS1 BAZ1B MCM3 YTHDC2 XRCC5 TRIM14 GTF3C3 USP10 NCAPG RNPEP DIAPH1	8.35e-07	1425	102	17	30948266
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TCEA1 PRPF31 IPO7 NSD2 POLA1 POLR1C BAZ1B MCM3 XRCC5 GTF3C3 USP10 NCAPG RNPEP DIAPH1	1.61e-06	1014	102	14	32416067
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PRPF31 SETX IPO7 NSD2 POLA1 BAZ1B E2F3 XRCC5 GTF3C3 ZNF644 ZMYM4	1.80e-06	608	102	11	36089195
Pubmed	Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.	AMER1 MCM3 DPP3	2.03e-06	9	102	3	24322982
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PRPF31 SETX IPO7 POLA1 ACLY POLR1C BMS1 BAZ1B MCM3 RICTOR XRCC5 GTF3C3 NCAPG NSFL1C RECQL4 DIAPH1	2.04e-06	1353	102	16	29467282
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TCEA1 ACLY BAZ1B MCM3 RICTOR YTHDC2 ITPRID2 LIG1 USP10 NSFL1C ZNF644 ZMYM4	2.94e-06	774	102	12	15302935
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	CALB1 CRTAC1 TWF2 CSPG5 TLL2 PICK1 PCSK9	3.01e-06	210	102	7	16537572
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO7 NSD2 POLA1 ACLY BMS1 BAZ1B YTHDC2 CUL7 XRCC5 GTF3C3 RNPEP	3.57e-06	653	102	11	22586326
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PRPF31 IPO7 ACLY POLR1C BMS1 BAZ1B DNAJC21 MCM3 YTHDC2 ITPRID2 XRCC5 TRIM14 GTF3C3 TWF1 USP10	3.96e-06	1257	102	15	36526897
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	PRPF31 BMS1 DNAJC21 MCM3 XRCC5 USP10 KCTD5	4.47e-06	223	102	7	33731348
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	TCEA1 PDE3A IPO7 POLA1 ACLY POLR1C MCM3 UNC13D TWF2 DPP3 XRCC5 TWF1 LIG1 NCAPG NSFL1C DIAPH1	5.16e-06	1455	102	16	22863883
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PRPF31 IPO7 POLA1 POLR1C BMS1 YTHDC2 DPP3 USP10 SPATA2L NSFL1C NEURL4 ZMYM4 WDR24	7.89e-06	1005	102	13	19615732
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	PRPF31 SETX ACLY BMS1 OBSL1 CUL7 GTF3C3 NCAPG ZNF644 RECQL4 CCDC15 ZMYM4	8.24e-06	857	102	12	25609649
Pubmed	Cloning, expression and characterization of an A6-related protein.	TWF2 TWF1	8.52e-06	2	102	2	10406962
Pubmed	Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.	OBSL1 CUL7	8.52e-06	2	102	2	34597859
Pubmed	Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.	TWF2 TWF1	8.52e-06	2	102	2	18837697
Pubmed	Twinfilin 2a regulates platelet reactivity and turnover in mice.	TWF2 TWF1	8.52e-06	2	102	2	28743718
Pubmed	Further expanding the mutational spectrum and investigation of genotype-phenotype correlation in 3M syndrome.	OBSL1 CUL7	8.52e-06	2	102	2	30980518
Pubmed	Calbindin and S100 protein expression in the developing inner ear in mice.	CALB1 S100A1	8.52e-06	2	102	2	19226521
Pubmed	Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis.	E2F2 E2F3	8.52e-06	2	102	2	23603666
Pubmed	Twinfilin, a molecular mailman for actin monomers.	TWF2 TWF1	8.52e-06	2	102	2	11870207
Pubmed	Contrasting roles of E2F2 and E2F3 in cardiac neovascularization.	E2F2 E2F3	8.52e-06	2	102	2	23799044
Pubmed	Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated.	TWF2 TWF1	8.52e-06	2	102	2	12807912
Pubmed	Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells.	NSD2 CD79A	8.52e-06	2	102	2	30566865
Pubmed	PTX promotes breast cancer migration and invasion by recruiting ATF4 to upregulate FGF19.	ATF4 FGF19	8.52e-06	2	102	2	39053672
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	KIF21B PRPF31 IPO7 ANPEP MCM3 ITPRID2 XRCC5 SIL1 KCTD5	1.02e-05	468	102	9	36042349
Pubmed	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.	MCM3 XRCC5 LIG1	1.33e-05	16	102	3	28803780
Pubmed	Cell proliferation in the absence of E2F1-3.	MCM3 E2F2 E2F3	1.33e-05	16	102	3	21185283
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TCEA1 AMER1 SETX BAZ1B UNC13D RICTOR ALS2 PRAMEF18 VILL NFE2L1 DIAPH1 VPS13B SERTAD3	1.75e-05	1084	102	13	11544199
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KIF21B ACLY POLR1C BAZ1B MCM3 TWF2 ITPRID2 XRCC5 TWF1 USP10	2.52e-05	660	102	10	32780723
Pubmed	A rare cause of syndromic short stature: 3M syndrome in three families.	OBSL1 CUL7	2.55e-05	3	102	2	33258289
Pubmed	Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.	E2F2 E2F3	2.55e-05	3	102	2	20404092
Pubmed	RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.	XRCC5 RECQL4	2.55e-05	3	102	2	24942867
Pubmed	Three M Syndrome	OBSL1 CUL7	2.55e-05	3	102	2	20301654
Pubmed	PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.	NSD2 ACLY	2.55e-05	3	102	2	35069527
Pubmed	Transcription factor compensation during mammary gland development in E2F knockout mice.	E2F2 E2F3	2.55e-05	3	102	2	29617434
Pubmed	FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress.	ATF4 FGF19	2.55e-05	3	102	2	23205607
Pubmed	The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway.	OBSL1 CUL7	2.55e-05	3	102	2	22156540
Pubmed	The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer.	E2F2 E2F3	2.55e-05	3	102	2	24934442
Pubmed	Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2.	XRCC5 VAV1	2.55e-05	3	102	2	10673353
Pubmed	Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors.	E2F2 E2F3	2.55e-05	3	102	2	21245101
Pubmed	Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype.	ANPEP RNPEP	2.55e-05	3	102	2	23500679
Pubmed	Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth.	OBSL1 CUL7	2.55e-05	3	102	2	21737058
Pubmed	Mouse development with a single E2F activator.	E2F2 E2F3	2.55e-05	3	102	2	18594513
Pubmed	Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.	OBSL1 CUL7	2.55e-05	3	102	2	23018678
Pubmed	The E2F1-3 transcription factors are essential for cellular proliferation.	E2F2 E2F3	2.55e-05	3	102	2	11719808
Pubmed	An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells.	E2F2 E2F3	2.55e-05	3	102	2	28698574
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B SETX NSD2 BMS1 E2F3 USP10 NRXN2 KCTD5 ZMYM4	2.66e-05	529	102	9	14621295
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO7 BMS1 RICTOR ITPRID2 XRCC5 NEURL4	3.02e-05	202	102	6	33005030
Pubmed	Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.	GCK FGF19 PCSK9	3.62e-05	22	102	3	27146480
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	PRPF31 ACLY POLR1C BMS1 XRCC5 GTF3C3 USP10	4.22e-05	316	102	7	31665637
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PRPF31 IPO7 ACLY SYNE1 OBSL1 BAZ1B MCM3 YTHDC2 ITPRID2 CUL7 XRCC5 NEURL4	4.72e-05	1024	102	12	24711643
Pubmed	Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.	ANPEP RNPEP	5.09e-05	4	102	2	26311161
Pubmed	Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.	E2F2 E2F3	5.09e-05	4	102	2	26396186
Pubmed	Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F.	E2F2 E2F3	5.09e-05	4	102	2	8657141
Pubmed	E2f1-3 are critical for myeloid development.	E2F2 E2F3	5.09e-05	4	102	2	21115501
Pubmed	Myc requires distinct E2F activities to induce S phase and apoptosis.	E2F2 E2F3	5.09e-05	4	102	2	11511364
Pubmed	Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.	E2F2 E2F3	5.09e-05	4	102	2	25088905
Pubmed	EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.	E2F2 E2F3	5.09e-05	4	102	2	15716352
Pubmed	Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.	E2F2 E2F3	5.09e-05	4	102	2	12065245
Pubmed	HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors.	E2F2 E2F3	5.09e-05	4	102	2	24362522
Pubmed	MEKs/ERKs-mediated FBXO1/E2Fs interaction interference modulates G1/S cell cycle transition and cancer cell proliferation.	E2F2 E2F3	5.09e-05	4	102	2	36607545
Pubmed	E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.	E2F2 E2F3	5.09e-05	4	102	2	17167174
Pubmed	The 3M complex maintains microtubule and genome integrity.	OBSL1 CUL7	5.09e-05	4	102	2	24793695
Pubmed	The subcellular localization of E2F-4 is cell-cycle dependent.	E2F2 E2F3	5.09e-05	4	102	2	9144196
Pubmed	An E2F/miR-20a autoregulatory feedback loop.	E2F2 E2F3	5.09e-05	4	102	2	17135249
Pubmed	E2f3a and E2f3b contribute to the control of cell proliferation and mouse development.	E2F2 E2F3	5.09e-05	4	102	2	19015245
Pubmed	Study of Fgf15 gene expression in developing mouse brain.	CALB1 FGF19	5.09e-05	4	102	2	12915315
Pubmed	Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells.	VAV1 GAB1	5.09e-05	4	102	2	9891995
Pubmed	Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2.	E2F2 E2F3	5.09e-05	4	102	2	17855529
Pubmed	E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.	E2F2 E2F3	5.09e-05	4	102	2	20016602
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	IPO7 NSD2 SYNE1 BMS1 BAZ1B YTHDC2 ITPRID2	5.76e-05	332	102	7	25693804
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	IPO7 NSD2 BMS1 PPP2R3B RICTOR ITPRID2 CUL7 NCAPG PTPRG CSPG5 NEURL4 GAB1	5.95e-05	1049	102	12	27880917
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TCEA1 SETX IPO7 OBSL1 GTF3C3 LIG1 NCAPG ZMYM4	7.47e-05	469	102	8	27634302
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	IPO7 NSD2 POLA1 BMS1 ALG11 YTHDC2 SIL1 FBN2 NSFL1C NEURL4	7.66e-05	754	102	10	33060197
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	NSD2 BMS1 BAZ1B YTHDC2 XRCC5 USP10 ZMYM4	7.88e-05	349	102	7	25665578
Pubmed	Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a.	E2F2 E2F3	8.47e-05	5	102	2	17608565
Pubmed	Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.	E2F2 E2F3	8.47e-05	5	102	2	26192440
Pubmed	Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.	E2F2 E2F3	8.47e-05	5	102	2	17008321
Pubmed	Transcriptional regulation of AKT activation by E2F.	E2F2 E2F3	8.47e-05	5	102	2	15574337
Pubmed	Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.	RICTOR GCK	8.47e-05	5	102	2	22521878
Pubmed	Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.	E2F2 E2F3	8.47e-05	5	102	2	24276244
Pubmed	The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway.	E2F2 E2F3	8.47e-05	5	102	2	22022495
Pubmed	Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.	E2F2 E2F3	8.47e-05	5	102	2	8846921
Pubmed	Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.	CD79A IL7R	8.47e-05	5	102	2	34193976
Pubmed	Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.	E2F2 E2F3	8.47e-05	5	102	2	17881568
Pubmed	Cooperative assembly of a protein-DNA filament for nonhomologous end joining.	XRCC5 LIG1	8.47e-05	5	102	2	23620595
Pubmed	A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.	E2F2 E2F3	8.47e-05	5	102	2	19749980
Pubmed	Division and apoptosis of E2f-deficient retinal progenitors.	E2F2 E2F3	8.47e-05	5	102	2	20016601
Pubmed	SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.	RICTOR XRCC5 USP10	9.39e-05	30	102	3	34780058
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	POLR1C BMS1 MCM3 YTHDC2 XRCC5 GTF3C3 USP10 RECQL4	9.55e-05	486	102	8	30940648
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	NSD2 RDM1 XRCC5 LIG1 ZMYM4	1.03e-04	157	102	5	30686591
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	E2F2 RICTOR E2F3 CUL7 ZNF644 CST2 DIAPH1 ZMYM4	1.08e-04	495	102	8	27705803
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	PRPF31 ACLY BMS1 MCM3 XRCC5 KCTD5	1.12e-04	256	102	6	32698014
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	IPO7 POLA1 ACLY MCM3 XRCC5 GTF3C3 USP10 NCAPG DIAPH1	1.12e-04	638	102	9	33239621
Pubmed	Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.	CALB1 ANO1 PIEZO2	1.14e-04	32	102	3	33288908
Interaction	HECTD1 interactions	PRPF31 IPO7 NSD2 GPATCH1 POLR1C BMS1 OBSL1 BAZ1B DNAJC21 YTHDC2 CUL7 XRCC5 GTF3C3 USP10 NCAPG RECQL4 TTLL1 NEURL4 WDR24	3.17e-07	984	100	19	int:HECTD1
Interaction	PARP1 interactions	PRPF31 NSD2 POLA1 POLR1C BMS1 OBSL1 BAZ1B MCM3 RICTOR E2F3 YTHDC2 ITPRID2 CUL7 XRCC5 TRIM14 GTF3C3 LIG1 USP10 NCAPG ZNF644 RECQL4 ZMYM4	3.80e-07	1316	100	22	int:PARP1
Interaction	POLR2A interactions	TCEA1 SETX CALB1 NSD2 POLR1C OBSL1 BAZ1B MCM3 E2F3 CUL7 XRCC5 GTF3C3 RECQL4 NEURL4	4.06e-07	536	100	14	int:POLR2A
Interaction	TRIM52 interactions	SETX RICTOR YTHDC2 TRIM52 GTF3C3 ZNF644 RECQL4	4.47e-06	133	100	7	int:TRIM52
Interaction	PCNA interactions	NSD2 POLA1 ACLY OBSL1 BAZ1B E2F3 GCK CUL7 XRCC5 LIG1 USP10 RECQL4	6.51e-06	497	100	12	int:PCNA
Interaction	TFDP3 interactions	POLA1 RICTOR E2F3 ITPRID2	2.98e-05	36	100	4	int:TFDP3
Interaction	TRIM28 interactions	PRPF31 AMER1 IPO7 NSD2 POLA1 ACLY POLR1C OBSL1 BAZ1B MCM3 RICTOR E2F3 YTHDC2 CUL7 XRCC5 LIG1 NCAPG ZNF644 RECQL4 ZMYM4	3.16e-05	1474	100	20	int:TRIM28
Interaction	PNMA2 interactions	PRPF31 SETX RICTOR CUL7 GTF3C3 ZNF644 RECQL4 NEURL4	3.59e-05	251	100	8	int:PNMA2
Interaction	CDC6 interactions	POLA1 PPP2R3B MCM3 E2F2 E2F3 PROZ	3.74e-05	125	100	6	int:CDC6
Interaction	IFI16 interactions	PRPF31 IPO7 NSD2 ACLY SYNE1 POLR1C BMS1 BAZ1B YTHDC2 ITPRID2 XRCC5 GTF3C3 USP10	5.18e-05	714	100	13	int:IFI16
Interaction	RUVBL2 interactions	PRPF31 POLR1C OBSL1 CRTAC1 RICTOR RDM1 CUL7 XRCC5 LIG1 USP10 NCAPG RECQL4	5.40e-05	616	100	12	int:RUVBL2
Interaction	NUP43 interactions	SETX NSD2 POLA1 GPATCH1 BMS1 RICTOR ITPRID2 CUL7 ZNF644 GUCY2D RECQL4 ZMYM4	6.21e-05	625	100	12	int:NUP43
Interaction	FBL interactions	PRPF31 IPO7 POLR1C BMS1 OBSL1 BAZ1B YTHDC2 CUL7 GTF3C3 ZNF644 RECQL4 ZMYM4	7.67e-05	639	100	12	int:FBL
Interaction	CDC5L interactions	STK36 SETX IPO7 SYNE1 GPATCH1 BMS1 OBSL1 MCM3 RICTOR CUL7 TWF1 USP10 RECQL4 DIAPH1	8.19e-05	855	100	14	int:CDC5L
Interaction	CBX3 interactions	AMER1 NSD2 ACLY OBSL1 BAZ1B CUL7 TRIM14 LIG1 ZNF644 RECQL4 DIAPH1 ZMYM4	8.50e-05	646	100	12	int:CBX3
Interaction	ZNF764 interactions	OBSL1 YTHDC2 GTF3C3 RECQL4 PICK1	1.00e-04	93	100	5	int:ZNF764
Interaction	CENPA interactions	PRPF31 IPO7 NSD2 BMS1 BAZ1B XRCC5 GTF3C3 ZNF644 DIAPH1	1.08e-04	377	100	9	int:CENPA
Interaction	DNAJC9 interactions	ACLY BMS1 OBSL1 BAZ1B MCM3 XRCC5 GTF3C3 RECQL4	1.14e-04	296	100	8	int:DNAJC9
Interaction	RUVBL1 interactions	PRPF31 ACLY POLR1C OBSL1 CRTAC1 RICTOR CUL7 USP10 NCAPG RECQL4 VAV1	1.32e-04	575	100	11	int:RUVBL1
Interaction	WDR75 interactions	KIF21B OBSL1 RICTOR CUL7 RECQL4	1.70e-04	104	100	5	int:WDR75
Interaction	TOP1 interactions	PRPF31 NSD2 POLA1 OBSL1 BAZ1B MCM3 CUL7 XRCC5 GTF3C3 LIG1 DIAPH1 IL7R	1.71e-04	696	100	12	int:TOP1
Interaction	POLE3 interactions	KIF21B POLA1 XRCC5 LIG1 RECQL4	1.85e-04	106	100	5	int:POLE3
Interaction	XRCC6 interactions	NSD2 GPATCH1 BMS1 OBSL1 BAZ1B RICTOR YTHDC2 CUL7 XRCC5 USP10 NSFL1C RECQL4 DIAPH1 VAV1	1.93e-04	928	100	14	int:XRCC6
Interaction	PRMT1 interactions	PRPF31 IPO7 ACLY POLR1C BMS1 OBSL1 MCM3 YTHDC2 CUL7 XRCC5 TWF1 USP10 NCAPG RECQL4	1.95e-04	929	100	14	int:PRMT1
Interaction	PTEN interactions	STK36 SETX IPO7 NSD2 MCM3 YTHDC2 ITPRID2 XRCC5 GTF3C3 USP10 FBN2 NSFL1C PICK1 OSGIN1	1.95e-04	929	100	14	int:PTEN
Interaction	NCAPH2 interactions	PRPF31 RICTOR TRIM52 GTF3C3 NCAPG ZNF644	1.98e-04	169	100	6	int:NCAPH2
Interaction	NSUN5P1 interactions	SETX RICTOR CUL7 RECQL4	2.11e-04	59	100	4	int:NSUN5P1
Interaction	PCGF6 interactions	E2F2 RICTOR E2F3 TRIM14 TRIM52 ZNF644	2.11e-04	171	100	6	int:PCGF6
Interaction	SMARCA5 interactions	NSD2 POLR1C OBSL1 BAZ1B MCM3 CUL7 XRCC5 NCAPG RECQL4	2.22e-04	415	100	9	int:SMARCA5
Interaction	HMGA1 interactions	STK36 NSD2 OBSL1 BAZ1B CUL7 XRCC5 USP10 ZNF644 ZMYM4	2.39e-04	419	100	9	int:HMGA1
Interaction	EED interactions	TCEA1 SETX IPO7 NSD2 ACLY BAZ1B MCM3 RICTOR TWF2 CUL7 XRCC5 GTF3C3 LIG1 USP10 RNPEP VILL GUCY2D VAV1	2.45e-04	1445	100	18	int:EED
GeneFamily	E2F transcription factors	E2F2 E2F3	3.51e-04	8	65	2	982
GeneFamily	Cadherin related	DCHS2 FAT2	1.67e-03	17	65	2	24
GeneFamily	Aminopeptidases\|CD molecules	ANPEP RNPEP	1.67e-03	17	65	2	104
Coexpression	GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN	CALB1 ANPEP BAZ1B ITPRID2 RNF14 USP10 ATF4	1.31e-05	199	102	7	M3912
Coexpression	HE_LIM_SUN_FETAL_LUNG_C5_LARGE_PRE_B_CELL	PRPF31 IPO7 NSD2 POLA1 ACLY BAZ1B DNAJC21 MCM3 E2F2 E2F3 DPP3 LIG1 NCAPG RNPEP RECQL4 DIAPH1 IL7R	1.94e-05	1363	102	17	M45782
Coexpression	CAIRO_HEPATOBLASTOMA_CLASSES_UP	TCEA1 IPO7 NSD2 ACLY POLR1C MCM3 XRCC5 GTF3C3 LIG1 USP10 NCAPG	2.68e-05	612	102	11	M4772
CoexpressionAtlas	B cells, proB.FrBC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-1	NSD2 POLA1 DNAJC21 E2F2 LIG1 NCAPG CD79A IL7R RAPGEFL1	6.62e-05	376	99	9	GSM538418_500
CoexpressionAtlas	B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3	NSD2 POLA1 DNAJC21 MCM3 E2F2 LIG1 NCAPG CD79A IL7R	1.06e-04	400	99	9	GSM538358_500
CoexpressionAtlas	B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2	NSD2 POLA1 DNAJC21 E2F2 LIG1 NCAPG CD79A IL7R RAPGEFL1	1.08e-04	401	99	9	GSM399450_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	SETX NSD2 POLA1 BMS1 DNAJC21 MCM3 ALS2 YTHDC2 XRCC5 GTF3C3 LIG1 NCAPG DIAPH1	1.14e-04	822	99	13	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlas	B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3	NSD2 POLA1 MCM3 E2F2 E2F3 LIG1 NCAPG CD79A IL7R	1.25e-04	409	99	9	GSM399452_500
CoexpressionAtlas	alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3	NSD2 POLA1 MCM3 E2F2 E2F3 XRCC5 LIG1 USP10 NCAPG	1.35e-04	413	99	9	GSM791149_500
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 E2F2 RDM1 CSMD2 LIG1 NCAPG RECQL4	8.94e-09	180	102	8	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	POLA1 MCM3 E2F2 E2F3 LIG1 NCAPG RECQL4 CCDC15	1.67e-08	195	102	8	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	POLA1 MCM3 E2F2 LIG1 NCAPG CSPG5 RECQL4 CCDC15	1.95e-08	199	102	8	1d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 E2F2 LIG1 NCAPG RECQL4 CCDC15	1.27e-07	169	102	7	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	POLA1 MCM3 RDM1 CSMD2 LIG1 NCAPG RECQL4	1.88e-07	179	102	7	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.25e-07	194	102	7	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	Control-Lymphoid_T/NK-T/NK_proliferative\|Control / Disease group, lineage and cell class	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.25e-07	194	102	7	9bbb124001fba7450f4639f47f9b720a483e7242
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ANO1 MCM3 E2F2 LIG1 NCAPG RECQL4 FGF19	3.25e-07	194	102	7	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.25e-07	194	102	7	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.25e-07	194	102	7	17744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.25e-07	194	102	7	e14f66f7584909621b776292fbd52808273fd2ee
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NSD2 POLA1 MCM3 LIG1 NCAPG RECQL4 CCDC15	3.36e-07	195	102	7	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	POLA1 MCM3 E2F3 LIG1 NCAPG RECQL4 CCDC15	3.36e-07	195	102	7	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NSD2 POLA1 MCM3 LIG1 NCAPG RECQL4 CCDC15	3.48e-07	196	102	7	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.86e-07	199	102	7	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.86e-07	199	102	7	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.86e-07	199	102	7	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.99e-07	200	102	7	e4eb915c29909cf8535a3603c68976545c05e54b
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.99e-07	200	102	7	415e7556b5ac45688e2c6c30a52bd40e0eb27c7d
ToppCell	3'_v3-Lung-Lymphocytic_NK-Cycling_NK\|Lung / Manually curated celltypes from each tissue	NSD2 MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	3.99e-07	200	102	7	381bafdde6492f020ae93ab8fffa6215c631c570
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG RECQL4	3.99e-07	200	102	7	04bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	POLA1 MCM3 E2F2 LIG1 NCAPG RECQL4 CCDC15	3.99e-07	200	102	7	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG RECQL4	3.99e-07	200	102	7	f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 E2F2 LIG1 NCAPG RECQL4	2.40e-06	167	102	6	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	GPATCH1 PPP2R3B MCM3 RDM1 NCAPG CCDC15	2.57e-06	169	102	6	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG	2.57e-06	169	102	6	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DCHS2 POLA1 MCM3 LIG1 NCAPG CCDC15	2.84e-06	172	102	6	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 E2F2 LIG1 NCAPG RECQL4	3.58e-06	179	102	6	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DCHS2 POLA1 GPATCH1 RECQL4 PCSK9 OSGIN1	4.06e-06	183	102	6	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 E2F2 RDM1 LIG1 NCAPG RECQL4	4.60e-06	187	102	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	10x5'-Liver-Lymphocytic_NK-Cycling_NK\|Liver / Manually curated celltypes from each tissue	NSD2 MCM3 E2F2 LIG1 NCAPG RECQL4	4.74e-06	188	102	6	5eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLA1 MCM3 LIG1 NCAPG FBN2 CSPG5	4.74e-06	188	102	6	61ae7405ab56570409bf35382dc0a038e4137c15
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLA1 MCM3 LIG1 NCAPG FBN2 CSPG5	5.19e-06	191	102	6	15dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLA1 MCM3 LIG1 NCAPG FBN2 CSPG5	5.19e-06	191	102	6	45c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCell	Control-Lymphocyte-T_NK-T_NK_proliferative\|Control / Disease, Lineage and Cell Type	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	5.68e-06	194	102	6	844731b7943d1cfca819b7b89e4e62067bfa0230
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM3 E2F2 LIG1 NCAPG CSPG5 RECQL4	5.68e-06	194	102	6	4c1d13d8cb6fb424655c67755ee6dbaf59d6b418
ToppCell	facs-Thymus-nan-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG	5.85e-06	195	102	6	93c345e70d6c8ff5d12fd63d73228c1700b804a0
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	POLA1 MCM3 E2F2 LIG1 NCAPG RECQL4	5.85e-06	195	102	6	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG	5.85e-06	195	102	6	043e2f19d95e94cd5219e2c415f322ed340aa80f
ToppCell	Control-T/NK_proliferative\|Control / Disease condition and Cell class	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.02e-06	196	102	6	7b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-Large_pre-B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MCM3 E2F2 LIG1 NCAPG RECQL4 CD79A	6.20e-06	197	102	6	cebf47d66f425c84d3fea962e11f5bf4bfe2e60f
ToppCell	(0)_NK_cells-(0)_NK_Dividing\|(0)_NK_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.38e-06	198	102	6	d9cdbc7d420472cb1ffb36ad9c8e53a61b7dbdeb
ToppCell	COVID-19_Severe-T/NK_proliferative\|World / disease group, cell group and cell class	POLA1 MCM3 RDM1 LIG1 NCAPG RECQL4	6.38e-06	198	102	6	48045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCell	(0)_NK_Dividing\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.38e-06	198	102	6	5ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NSD2 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	10x5'v1-week_12-13-Lymphocytic_B-B_lineage-pre_pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MCM3 XRCC5 LIG1 NCAPG CD79A IL7R	6.57e-06	199	102	6	5478b78349b5d8d57f30bb650dcbd5fdb84283d6
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NSD2 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	MCM3 E2F2 LIG1 NCAPG CSPG5 RECQL4	6.57e-06	199	102	6	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	101f78fe6dd1bf9e2e4dd5ad8a970312b3540927
ToppCell	normal_Lung-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	NSD2 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	4142d5b1b20212508f95841fdac4efb7655616cb
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	e0fcec796afe75e42467ca86355b9fc5aa9ae0a1
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	NSD2 MCM3 E2F2 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / disease group, cell group and cell class	MCM3 RDM1 LIG1 NCAPG RECQL4 CCDC15	6.57e-06	199	102	6	af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCell	mild_COVID-19-T/NK_proliferative\|mild_COVID-19 / disease group, cell group and cell class (v2)	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.57e-06	199	102	6	df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.76e-06	200	102	6	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	Control-Control-Lymphocyte-T/NK-T/NK_proliferative\|Control / Disease, condition lineage and cell class	MCM3 E2F2 RDM1 LIG1 NCAPG RECQL4	6.76e-06	200	102	6	6cf63dd57f6bc0c42e7182322dd24ff9afbe9186
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG	6.76e-06	200	102	6	7e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NSD2 POLA1 MCM3 E2F2 LIG1 NCAPG	6.76e-06	200	102	6	9775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCell	P07-Hematopoietic\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	E2F2 GUCY2D CD79A VAV1 IL7R	1.66e-05	138	102	5	fb8038393c2b88eb29bd23574c0c6178644900be
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF21B POLA1 MCM3 DPP3 LIG1	3.27e-05	159	102	5	95128a2367ff2a639b21913c0350924c174faef8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STK36 E2F2 LIG1 RECQL4 CCDC15	3.79e-05	164	102	5	1642a67c66eeb77a218e7814e3cfe517d9822955
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STK36 E2F2 LIG1 RECQL4 CCDC15	3.79e-05	164	102	5	25758fb8112baf296264122d5d4121f1ebb3d0fa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 LIG1 NCAPG RECQL4 CCDC15	3.90e-05	165	102	5	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NSD2 POLA1 LIG1 NCAPG RECQL4	4.37e-05	169	102	5	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NSD2 POLA1 MCM3 LIG1 NCAPG	4.76e-05	172	102	5	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK\|bone_marrow / Manually curated celltypes from each tissue	MCM3 E2F2 RDM1 LIG1 NCAPG	4.89e-05	173	102	5	8a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell	BL-critical-LOC-Lymphoid-PC\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	E2F2 SIL1 NCAPG CD79A GAB1	4.89e-05	173	102	5	90700a876d997f7c0f7b3899dffcda7fdafee547
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NSD2 POLA1 MCM3 LIG1 NCAPG	5.02e-05	174	102	5	c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 CALB1 CNTNAP5 IQCJ-SCHIP1 GAB1	5.02e-05	174	102	5	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A ANO1 PIEZO2 PTPRG NRXN2	5.02e-05	174	102	5	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 CALB1 CNTNAP5 IQCJ-SCHIP1 GAB1	5.30e-05	176	102	5	40993c41c1017b53039a337174fc56632b278609
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A6 ANO1 PIEZO2 NRXN2 ARMH4	5.45e-05	177	102	5	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A6 ANO1 PIEZO2 NRXN2 ARMH4	5.45e-05	177	102	5	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	STK36 PPP2R3B RDM1 NCAPG CCDC15	5.60e-05	178	102	5	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 POLA1 MCM3 LIG1 NCAPG	5.60e-05	178	102	5	79823d13652177de852c2acce9159049241f1d86
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B STK36 ADHFE1 NRXN2 TTLL1	5.75e-05	179	102	5	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCM3 DPP3 LIG1 NCAPG RECQL4	6.06e-05	181	102	5	6873c1138b28c130637d06b64981ad11c262e85f
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T\|Liver / Manually curated celltypes from each tissue	MCM3 E2F2 LIG1 NCAPG RECQL4	6.22e-05	182	102	5	81557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POLA1 MCM3 LIG1 NCAPG RECQL4	6.38e-05	183	102	5	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NSD2 POLA1 MCM3 LIG1 NCAPG	6.55e-05	184	102	5	1edefa2a049d7e22d0bdb1ea3d7ef1c8d6ae0fe3
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NSD2 POLA1 MCM3 LIG1 NCAPG	6.55e-05	184	102	5	8578c50eaa8ce1cefc0228185c66c8e25f4bfc32
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 POLA1 MCM3 LIG1 NCAPG	6.55e-05	184	102	5	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MCM3 RDM1 LIG1 NCAPG CCDC15	6.89e-05	186	102	5	4fe8e0bf74c7dbf73634cafdacad89020d2634d0
ToppCell	droplet-Fat-SCAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO7 POLA1 ANO1 PIEZO2 TTLL1	7.07e-05	187	102	5	5fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCell	droplet-Fat-SCAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO7 POLA1 ANO1 PIEZO2 TTLL1	7.07e-05	187	102	5	766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SECISBP2L ADAMTSL1 UNC13D FBN2 IQCJ-SCHIP1	7.07e-05	187	102	5	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	droplet-Fat-SCAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO7 POLA1 ANO1 PIEZO2 TTLL1	7.07e-05	187	102	5	f49d06600060deeb2fc1b1da5b93496535f20104
ToppCell	PBMC-Mild-cDC_12\|Mild / Compartment, Disease Groups and Clusters	POLA1 MCM3 E2F2 LIG1 NCAPG	7.43e-05	189	102	5	946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NSD2 E2F2 NCAPG RECQL4 CCDC15	7.43e-05	189	102	5	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 PDE3A ADAMTSL1 PIEZO2 LOXHD1	7.62e-05	190	102	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	NSD2 MCM3 E2F2 RDM1 LIG1	7.62e-05	190	102	5	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 PDE3A ADAMTSL1 PIEZO2 LOXHD1	7.62e-05	190	102	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 PDE3A ADAMTSL1 PIEZO2 LOXHD1	7.81e-05	191	102	5	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 POLA1 MCM3 LIG1 NCAPG	7.81e-05	191	102	5	239300ff76f2c855b2b04d3002461158be90a01b
ToppCell	Dividing_Macrophages-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	E2F2 RDM1 NCAPG RECQL4 CCDC15	7.81e-05	191	102	5	3e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 MCM3 E2F3 LIG1 NCAPG	7.81e-05	191	102	5	c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MCM3 E2F2 LIG1 NCAPG CCDC15	7.81e-05	191	102	5	50854384fdaa0efa2e3227659d544ed09ac102f2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 PDE3A ADAMTSL1 PIEZO2 LOXHD1	8.00e-05	192	102	5	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 PDE3A ADAMTSL1 PIEZO2 LOXHD1	8.00e-05	192	102	5	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSD2 SYNE1 MCM3 PIEZO2 PTPRG	8.00e-05	192	102	5	1ccc47792edf9ee23501c8e2165d11271636b66a
Computational	Neighborhood of PRKDC	TCEA1 PRPF31 NSD2 BMS1 BAZ1B MCM3 XRCC5 RNPEP DIAPH1	1.14e-06	191	61	9	MORF_PRKDC
Computational	Neighborhood of BUB3	TCEA1 PRPF31 IPO7 NSD2 ACLY BAZ1B MCM3 XRCC5 RNPEP	2.36e-05	277	61	9	MORF_BUB3
Computational	Neighborhood of XRCC5	TCEA1 PRPF31 NSD2 ACLY BAZ1B XRCC5 RNPEP DIAPH1	5.02e-05	235	61	8	MORF_XRCC5
Computational	Neighborhood of RAD23A	TCEA1 PRPF31 NSD2 ACLY BAZ1B MCM3 XRCC5 RNPEP DIAPH1	1.38e-04	348	61	9	MORF_RAD23A
Computational	Neighborhood of HDAC2	TCEA1 PRPF31 NSD2 BMS1 BAZ1B XRCC5 RNPEP ZMYM4	1.71e-04	280	61	8	MORF_HDAC2
Computational	Genes in the cancer module 198.	IPO7 POLA1 MCM3 E2F3 XRCC5 LIG1 RECQL4 ATF4	2.92e-04	303	61	8	MODULE_198
Computational	Neighborhood of GNB1	TCEA1 PRPF31 NSD2 BAZ1B XRCC5 RNPEP DIAPH1 ATF4	3.05e-04	305	61	8	MORF_GNB1
Computational	Neighborhood of PPP1CC	TCEA1 IPO7 NSD2 BAZ1B MCM3 XRCC5	3.41e-04	166	61	6	MORF_PPP1CC
Computational	TFs and nuclear.	IPO7 POLA1 MCM3 E2F3 XRCC5 LIG1 RECQL4	3.67e-04	237	61	7	MODULE_252
Computational	Neighborhood of EIF3S2	TCEA1 PRPF31 ACLY BAZ1B XRCC5 RNPEP ATF4	4.59e-04	246	61	7	MORF_EIF3S2
Computational	Genes in the cancer module 318.	MCM3 XRCC5 RECQL4	5.15e-04	28	61	3	MODULE_318
Computational	Neighborhood of DNMT1	TCEA1 NSD2 BAZ1B MCM3 XRCC5	5.33e-04	118	61	5	MORF_DNMT1
Computational	Response to DNA damage.	POLA1 MCM3 XRCC5 LIG1 GUCY2D RECQL4	6.42e-04	187	61	6	MODULE_244
Computational	Neighborhood of CDC16	NSD2 BAZ1B XRCC5 DIAPH1	8.45e-04	75	61	4	MORF_CDC16
Computational	Neighborhood of AATF	TCEA1 PRPF31 ACLY BMS1 BAZ1B XRCC5	1.15e-03	209	61	6	MORF_AATF
Computational	Genes in the cancer module 98.	IPO7 POLA1 MCM3 E2F3 XRCC5 LIG1 RECQL4 ATF4	1.60e-03	393	61	8	MODULE_98
Computational	DNA replication.	POLA1 MCM3 LIG1	1.83e-03	43	61	3	MODULE_158
Computational	Genes in the cancer module 125.	POLA1 MCM3 LIG1	1.95e-03	44	61	3	MODULE_125
Computational	Metal ion (zinc) binding.	ANPEP PTPRG PAM	2.08e-03	45	61	3	MODULE_280
Computational	DNA damage response.	MCM3 XRCC5 RECQL4	2.22e-03	46	61	3	MODULE_403
Computational	Neighborhood of RRM1	NSD2 BAZ1B MCM3 XRCC5	2.64e-03	102	61	4	MORF_RRM1
Disease	3-M syndrome (is_implicated_in)	OBSL1 CUL7	3.20e-05	3	97	2	DOID:0060241 (is_implicated_in)
Disease	3-M syndrome	OBSL1 CUL7	3.20e-05	3	97	2	cv:C1848862
Disease	Ataxias, Hereditary	SETX SIL1	2.96e-04	8	97	2	C0004138
Disease	response to TNF antagonist	PDE3A CSMD2 CST2	7.56e-04	54	97	3	EFO_0004653
Disease	ascending aortic diameter	ANO1 UNC13D PIEZO2 FBN2	1.20e-03	140	97	4	EFO_0021787
Disease	Amyotrophic lateral sclerosis	SETX ALS2	1.41e-03	17	97	2	cv:C0002736
Disease	food allergy measurement, parental genotype effect measurement	DCHS2 PROZ	1.58e-03	18	97	2	EFO_0005939, EFO_0007016
Disease	Nonsyndromic genetic hearing loss	LOXHD1 DIAPH1 GAB1	2.03e-03	76	97	3	cv:C5680182
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	CRTAC1 E2F3 GCK PCSK9	2.23e-03	166	97	4	EFO_0004530, EFO_0004611
Disease	blood pressure	SYNE1 CNTNAP5	2.37e-03	22	97	2	EFO_0004325
Disease	susceptibility to childhood ear infection measurement	ANO1 SIL1 GUCY2D VPS13B	2.48e-03	171	97	4	EFO_0007904

Protein segments in the cluster

Peptide	Gene	Start	Entry
GEEYQELQLDGFDNE	PTPRG	96	P23470
EGDITGFLAESEEDY	ALG11	431	Q2TAA5
EEYNGVIEEFLATGE	RNPEP	261	Q9H4A4
DFQLEDGYDFLEVTG	CSMD2	246	Q7Z408
DIIDIDYFEGLDGEG	CSPG5	206	O95196
GVLLSEDDTIYEGEF	ALS2	1211	Q96Q42
TLLQDEIAEDYGELG	BAZ1B	661	Q9UIG0
GAEESLGLLDDYLEV	ATF4	26	P18848
SYGLDQLESEEGQED	ARMH4	601	Q86TY3
EEEVLDQGDFYSLLS	PAM	381	P19021
DEDLAASLEAFELGY	AMER1	831	Q5JTC6
EFEGELADDLAGFYR	ANPEP	181	P15144
NEKLGLDAGDEYEDE	CD79A	171	P11912
LDAGDEYEDENLYEG	CD79A	176	P11912
DEQGEEDSYDLKGRL	DIAPH1	366	O60610
DEELYGDFEDLETGD	BMS1	776	Q14692
ETLDLEEAEGAVGYQ	NFE2L1	531	Q14494
DLDGDGALSMFELEY	PPP2R3B	401	Q9Y5P8
GDSGELDEFLLEYDR	GCK	261	P35557
GQEEEGYLSDFSLEE	RDM1	261	Q8NG50
GLEDVQVYDGEDAVF	OBSL1	621	O75147
LGETEDLLSFEAYEL	KLHL33	426	A6NCF5
LQLEDLDGFEGYSLS	LYZL6	31	O75951
LGGEEQRYLLEAAEE	GUCY2D	251	Q02846
GDKQVEYLDLDLDSG	GAB1	621	Q13480
SGSLQLDEEDEDAYF	FRMD7	681	Q6ZUT3
AELLNYASEDDEGEL	LOXHD1	21	Q8IVV2
DGLFGGLQDFDELYD	ADAMTSL1	596	Q8N6G6
FGVGALEEEDDDIYA	GPATCH1	286	Q9BRR8
QEDEDGDYEELVLAL	PCSK9	31	Q8NBP7
AQDDDSGLDGELQYF	FAT2	1056	Q9NYQ8
DDIDEDGQEYLEILA	IPO7	906	O95373
EFYEQGDEEASLGLP	PDE3A	971	Q14432
LDDYEEISAGDEGEF	CUL7	386	Q14999
EDGAEGYSDLFRENA	KIF21B	411	O75037
ETLALTYGFLEEEDL	PRAMEF18	296	Q5VWM3
GEFVNEYVGELIDEE	NSD2	1086	O96028
GLLQYSEEDCAFEEE	FGF19	111	O95750
LLYLDDGGDCDFLEL	NRXN2	66	Q9P2S2
EIFGFEGADAEDVIY	DPP3	526	Q9NY33
QNGDLEDAELDDYSF	IL7R	26	P16871
YEGNLLEAGLELERD	ANO1	131	Q5XXA6
GFDGEYQDDSLDLLR	DNAJC21	76	Q5F1R6
IALASFYEDGGDEDI	NSFL1C	36	Q9UNZ2
EEILYNLGFGRDEPD	ITPRID2	181	P28290
FLLESEEDGQGYLED	RICTOR	611	Q6R327
EEDGQGYLEDLVKDI	RICTOR	616	Q6R327
LGDEDEEIDGDTNKY	POLA1	816	P09884
DEGLNGQTEYFLTDE	DCHS2	1961	Q6V1P9
QRDYLDFLDDEEDQG	MCM3	16	P25205
VDQDLEYLSEGLEGR	OSGIN2	66	Q9Y236
LEAGEGISDLFDSYD	E2F2	416	Q14209
QEDYLLSLGEEEGIS	E2F3	431	O00716
DGNGYIDENELDALL	CALB1	201	P05937
DLAEEGVLEEAEFYN	KCTD5	116	Q9NXV2
DIDGDGREEIYFLNT	CRTAC1	121	Q9NQ79
EDRIIEGGIYDADLN	CST2	26	P09228
LEESNEDDYLLGELG	FBN2	2886	P35556
GGFLLASYDEDSEEL	LIG1	776	P18858
LQDDLDDYGFEDYGT	PPP4R1L	11	Q9P1A2
SVLEEYGQDLDQLGE	NEURL4	141	Q96JN8
GETDALDIDYELSFG	CNTNAP5	296	Q8WYK1
DTEEADIYLLIDGSG	COL6A6	431	A6NMZ7
LDQDLDYLSEGLEGR	OSGIN1	66	Q9UJX0
LFDLDVDDGLAAVGY	ADHFE1	411	Q8IWW8
LQEDEGSEDASLYGE	SPATA2L	231	Q8IUW3
ELDENGDGEVDFQEY	S100A1	61	P23297
GVYDDGLEELSDALN	TAAR6	171	Q96RI8
EDEEGQDDKDFYLRG	SYNE1	8306	Q8NF91
SDIEDEQLAYGFTEL	BMT2	361	Q1RMZ1
KDLLGRYFEEEEGQE	RECQL4	1101	O94761
IGDDDELYIVDNNGE	SETX	81	Q7Z333
VLASLELQDGEDEGY	SIL1	431	Q9H173
ELQDGEDEGYFQELL	SIL1	436	Q9H173
SLYFEDEDGFQELNE	SECISBP2L	386	Q93073
AGSYLLEELFEGNLE	PROZ	41	P22891
DDYIAIGADEEELGS	TCEA1	156	P23193
LFEYRNQGDEEGTEI	POLR1C	121	O15160
GGSLDLVSALEDYEE	IQCJ-SCHIP1	141	B3KU38
DYAEGELFQILEDDG	STK36	81	Q9NRP7
YLGDSGLDDFFLDID	SERTAD3	141	Q9UJW9
GDLYLDVAEAFLDVG	GTF3C3	421	Q9Y5Q9
EEADEYIDIGALNGI	ACLY	1046	P53396
EAQDYFLEAQGDLLE	CCDC15	331	Q0P6D6
DDEEEEDGGLLNYLF	NCAPG	86	Q9BPX3
EEEEEDQDYYLGGLR	TRIM52	126	Q96A61
DELLALASIYDGDEF	RNF14	11	Q9UBS8
VGDEDIYSGLSDQID	VAV1	136	P15498
DSEEALIYEEDFNGG	PIEZO2	171	Q9H5I5
GEIEEDAYQEDLGFS	PRPF31	381	Q8WWY3
YSELDGEEGTEQQLE	TLL2	36	Q9Y6L7
DLLQEEDFYILDQGG	VILL	276	O15195
DDLDRLGVFLDYEAG	TRIM14	386	Q14142
ASEEEGLNFLNEYDE	ZNF644	1141	Q9H582
TDEYDLLDDGGDAVF	YTHDC2	436	Q9H6S0
IVSYDDGEEDFVGND	VPS13B	356	Q7Z7G8
QEDAEEYLGFILNGL	USP10	521	Q14694
ADYLLGDVEGEEDEL	WDR24	536	Q96S15
FLDTYQGLLQEEEGA	RAPGEFL1	226	Q9UHV5
YGLNQEEFTDGEEEE	PICK1	371	Q9NRD5
YDTLGADDLEGEAFL	UNC13D	1006	Q70J99
EIGDGAELTAEFLYD	TWF2	296	Q6IBS0
LLDEDDYFLNSGDLA	ZMYM4	66	Q5VZL5
LYDEELAQGDGADRE	TTLL1	381	O95922
EGEDGLDEIYSFSES	XRCC5	216	P13010
EIDNGDELTADFLYE	TWF1	296	Q12792