Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionapolipoprotein A-I receptor activity

ABCA1 ABCA7

2.15e-052932GO:0034188
GeneOntologyMolecularFunctionapolipoprotein receptor activity

ABCA1 ABCA7

6.42e-053932GO:0030226
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA1 ABCA4 ABCD2 ABCA7

7.96e-0549934GO:0140359
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ABCA1 ABCA4 ABCA7

2.94e-0428933GO:0140326
GeneOntologyMolecularFunctionlipid transporter activity

ABCA1 ABCA4 APOA5 ABCD2 CERT1 ABCA7

3.11e-04196936GO:0005319
GeneOntologyMolecularFunctionphospholipid transporter activity

ABCA1 ABCA4 CERT1 ABCA7

3.95e-0474934GO:0005548
GeneOntologyMolecularFunctionphosphatidylcholine floppase activity

ABCA1 ABCA7

5.90e-048932GO:0090554
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ABCA1 ABCA7

7.56e-049932GO:0090556
GeneOntologyMolecularFunctionprotein-glutamine gamma-glutamyltransferase activity

TGM1 TGM7

7.56e-049932GO:0003810
DomainABC_A

ABCA1 ABCA4 ABCA7

2.63e-0512943IPR026082
DomainABC_transporter_CS

ABCA1 ABCA4 ABCD2 ABCA7

5.82e-0542944IPR017871
DomainABC_tran

ABCA1 ABCA4 ABCD2 ABCA7

9.88e-0548944PF00005
DomainABC_TRANSPORTER_2

ABCA1 ABCA4 ABCD2 ABCA7

9.88e-0548944PS50893
DomainABC_TRANSPORTER_1

ABCA1 ABCA4 ABCD2 ABCA7

1.07e-0449944PS00211
DomainABC_transporter-like

ABCA1 ABCA4 ABCD2 ABCA7

1.16e-0450944IPR003439
DomainMethyltransf_12

FASN HNMT

3.71e-046942PF08242
DomainDUF3669_Znf

ZNF398 ZNF783

3.71e-046942IPR022137
DomainDUF3669

ZNF398 ZNF783

3.71e-046942PF12417
DomainMethyltransf_12

FASN HNMT

3.71e-046942IPR013217
DomainPH-BEACH_dom

NBEA WDFY4

6.88e-048942IPR023362
Domain-

NBEA WDFY4

6.88e-0489422.30.29.40
DomainPH_BEACH

NBEA WDFY4

6.88e-048942PS51783
DomainAAA+_ATPase

ABCA1 ABCA4 ABCD2 DNAH5 ABCA7

8.04e-04144945IPR003593
DomainAAA

ABCA1 ABCA4 ABCD2 DNAH5 ABCA7

8.04e-04144945SM00382
DomainTransglut_N

TGM1 TGM7

8.82e-049942PF00868
DomainTRANSGLUTAMINASES

TGM1 TGM7

8.82e-049942PS00547
DomainTransglutaminase_N

TGM1 TGM7

8.82e-049942IPR001102
DomainTransglut_C

TGM1 TGM7

8.82e-049942PF00927
Domain-

TGM1 TGM7

8.82e-0499423.90.260.10
DomainBEACH_dom

NBEA WDFY4

8.82e-049942IPR000409
DomainGln_gamma-glutamylTfrase_euk

TGM1 TGM7

8.82e-049942IPR023608
DomainTransglutaminase_AS

TGM1 TGM7

8.82e-049942IPR013808
DomainBEACH

NBEA WDFY4

8.82e-049942PS50197
DomainBeach

NBEA WDFY4

8.82e-049942PF02138
Domain-

NBEA WDFY4

8.82e-0499421.10.1540.10
DomainBeach

NBEA WDFY4

8.82e-049942SM01026
DomainTransglutaminase_C

TGM1 TGM7

1.10e-0310942IPR008958
DomainTGc

TGM1 TGM7

1.34e-0311942SM00460
DomainTransglut_core

TGM1 TGM7

1.34e-0311942PF01841
DomainTransglutaminase-like

TGM1 TGM7

1.34e-0311942IPR002931
DomainTIL

MUC19 OTOG

1.60e-0312942PF01826
DomainC8

MUC19 OTOG

1.60e-0312942PF08742
DomainUnchr_dom_Cys-rich

MUC19 OTOG

1.89e-0313942IPR014853
DomainC8

MUC19 OTOG

1.89e-0313942SM00832
DomainIRS_PTB

TLN1 FRS3

2.19e-0314942IPR002404
DomainTIL_dom

MUC19 OTOG

2.19e-0314942IPR002919
DomainIRS

TLN1 FRS3

2.19e-0314942PF02174
DomainSTART

STARD9 CERT1

2.52e-0315942PF01852
DomainSTART_lipid-bd_dom

STARD9 CERT1

2.52e-0315942IPR002913
DomainSTART

STARD9 CERT1

2.52e-0315942PS50848
DomainVWD

MUC19 OTOG

2.87e-0316942SM00216
DomainVWF_type-D

MUC19 OTOG

2.87e-0316942IPR001846
DomainVWFD

MUC19 OTOG

2.87e-0316942PS51233
DomainVWD

MUC19 OTOG

2.87e-0316942PF00094
DomainVWC_out

MUC19 OTOG

4.05e-0319942SM00215
DomainCT

MUC19 OTOG

5.42e-0322942SM00041
DomainPH_dom-like

JAK3 TLN1 FRS3 NBEA CERT1 WDFY4 SHC3

5.71e-03426947IPR011993
Pubmed

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants.

ABCA1 ABCA4 ABCA7

1.97e-08395324097981
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CEP350 IPO5 DMXL2 EXOSC9 TTC7B ZNF473 CAMK2A TTLL5 YLPM1 PPP1R16B NBEA ARMCX4 HERC2 ITGB8 USP47

2.08e-061285951535914814
Pubmed

Oxygen modulates iron homeostasis by switching iron sensing of NCOA4.

HERC2 NCOA4

7.38e-06295237059186
Pubmed

CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.

HP CD163

7.38e-06295211854028
Pubmed

Haemoglobin scavenging after subarachnoid haemorrhage.

HP CD163

7.38e-06295225366599
Pubmed

ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1.

ABCA1 ABCA7

7.38e-06295226749169
Pubmed

Identification of the haemoglobin scavenger receptor.

HP CD163

7.38e-06295211196644
Pubmed

Lysophosphatidylcholine export by human ABCA7.

ABCA1 ABCA7

7.38e-06295228373057
Pubmed

Preferential incorporation of shorter and less unsaturated acyl phospholipids into high density lipoprotein-like particles in the ABCA1- and ABCA7-mediated biogenesis with apoA-I.

ABCA1 ABCA7

7.38e-06295225665932
Pubmed

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.

HP CD163

7.38e-06295219131549
Pubmed

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.

HP CD163

7.38e-06295217102136
Pubmed

Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.

ABCA1 ABCA7

7.38e-06295214570867
Pubmed

CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system.

HP CD163

7.38e-06295217460152
Pubmed

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.

HP CD163

7.38e-06295217525367
Pubmed

Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes.

HP CD163

7.38e-06295211865982
Pubmed

Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients.

HP CD163

7.38e-06295235011566
Pubmed

Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.

ABCA1 ABCA7

7.38e-06295215930518
Pubmed

A genome-wide association study of brain lesion distribution in multiple sclerosis.

RNASEL DSC1 MMP10

1.08e-051695323412934
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

CEP350 IPO5 FASN TLN1 HERC2 MTDH

1.12e-0518295631067453
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

TGM1 ABCA1 ABCA4 ABCD2 HNMT ABCA7

1.56e-0519395619343046
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

FASN HP PRCP TLN1 PACSIN3 MMRN2 LTA4H PATJ HNMT ITGB8 SFN SECTM1

2.13e-051016951219056867
Pubmed

CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing.

HP CD163

2.21e-05395223671278
Pubmed

The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.

HP CD163

2.21e-05395228464519
Pubmed

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.

CPQ MTDH

2.21e-05395220802479
Pubmed

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

HERC2 NCOA4

2.21e-05395226436293
Pubmed

Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.

RNASEL OASL

2.21e-05395216235172
Pubmed

Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent.

HP CD163

2.21e-05395218563533
Pubmed

Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria.

HP CD163

2.21e-05395222290142
Pubmed

ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.

ABCA1 ABCA7

2.21e-05395218793613
Pubmed

Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.

ABCA1 ABCA7

2.21e-05395222403608
Pubmed

Potential role of ABCA7 in cellular lipid efflux to apoA-I.

ABCA1 ABCA7

2.21e-05395215520449
Pubmed

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

HP CD163

2.21e-05395227294203
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

FASN DSC1 CPQ HP PRCP TLN1 PACSIN3 MMRN2 LTA4H PATJ SFN SECTM1

3.53e-051070951223533145
Pubmed

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

ABCA1 ABCA7

4.41e-05495220495215
Pubmed

Apoptotic engulfment pathway and schizophrenia.

ABCA1 ABCA7

4.41e-05495219721717
Pubmed

The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.

ABCA1 APOA5

4.41e-05495228865324
Pubmed

An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.

CITED1 SFN

4.41e-05495217938205
Pubmed

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.

ABCA1 ABCA7

7.34e-05595217142808
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CEP350 IPO5 TGM1 FANCB FASN HP TLN1 C11orf68 YLPM1 PACSIN3 HERC2 USP47

7.35e-051155951220360068
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

IPO5 TGM1 FASN DSC1

8.53e-058495429563501
Pubmed

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.

ABCA4 ABCA7

1.10e-04695212111378
Pubmed

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

FASN ABCA1

1.10e-04695227545894
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP350 RALGAPA1 DENND1B STARD9 CAMK2A TANC1 PATJ SFN OTOG ITPKB

1.24e-04861951036931259
Pubmed

Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.

TGM1 TGM7

1.54e-04795211390390
Pubmed

Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults.

ABCA1 APOA5

1.54e-04795223656756
Pubmed

Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.

FANCB INTU

1.54e-04795221948523
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CEP350 RALGAPA1 YLPM1 FNDC3A TANC1 NHLRC2 NCOA4 PATJ TRIP4

1.83e-0473395934672954
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RALGAPA1 SEC61A2 FAM184B DMXL2 TTLL5 TLN1 MRPL28 FNDC3A TANC1 HERC2 SLIRP MTDH TRIP4

2.02e-041487951333957083
Pubmed

MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.

FASN TLN1

2.05e-04895234131310
Pubmed

HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.

TGM1 TGM7

2.05e-0489527906657
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA1 ABCA7

2.05e-04895224293640
Pubmed

Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia.

ABCA1 APOA5

2.05e-04895215135251
Pubmed

Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.

TGM1 TGM7

2.05e-0489527688299
Pubmed

Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.

DNAH5 WDFY4

2.05e-04895217903303
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

IPO5 SEC61A2 TTLL5 RANBP6 MRPL28 FNDC3A TANC1 ARMCX4 HERC2 SLIRP BCL2L13 MTDH USP47

2.15e-041496951332877691
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

FASN HP TLN1

2.41e-044495331273033
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CEP350 EXOSC9 FASN STARD9 TLN1 YLPM1 PACSIN3 HERC2 SLIRP MTDH TRIP4 SHC3

3.58e-041371951236244648
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IPO5 FASN TLN1 YLPM1 OASL LTA4H HERC2 USP47

4.29e-0465395822586326
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

FNIP2 RALGAPA1 DMXL2 FNDC3A NBEA BCL2L13 MTDH

4.75e-0450495734432599
Pubmed

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

IPO5 SFN

4.79e-041295229686263
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CEP350 IPO5 EXOSC9 FASN RBM12B TLN1 YLPM1 PACSIN3 HERC2 MTDH

4.94e-041024951024711643
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

IPO5 RALGAPA1 TGM1 DMXL2 FASN TTC7B CAMK2A TLN1 NBEA TANC1 MTDH ITPKB

5.25e-041431951237142655
Pubmed

A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.

CAMK2A TANC1

5.65e-041395215673434
Pubmed

Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy.

ABCA1 APOA5

5.65e-041395217700364
Pubmed

Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.

ABCA1 APOA5 ABCA7

5.74e-045995320855565
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

JAK3 TGM1 ABCA1 RNASEL ABCA7 IL6R

5.78e-0437495619625176
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

FASN ABCA1 APOA5 NCOA4 ABCD2

6.31e-0425095518660489
Pubmed

Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

ABCA1 APOA5 HP

6.33e-046195322916037
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

JAK3 TGM1 ABCA1 RNASEL ABCA7 IL6R

6.36e-0438195618676680
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

JAK3 TGM1 ABCA1 RNASEL ABCA7 IL6R

6.45e-0438295619170196
Pubmed

Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants.

ABCA1 APOA5

7.57e-041595216763159
Pubmed

Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

ABCA1 APOA5

7.57e-041595220160193
Pubmed

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

MUC19 HERC2

8.64e-041695219068216
Pubmed

IRF6 and AP2A Interaction Regulates Epidermal Development.

TGM1 DSC1

8.64e-041695229913133
Pubmed

Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.

ABCA1 APOA5

8.64e-041695217855807
Pubmed

Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics.

CAMK2A PATJ

8.64e-041695219138174
Pubmed

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.

FRS3 SHC3

8.64e-041695219943849
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

IPO5 RANBP6 MRPL28 SFN

8.82e-0415595434921745
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAK3 FASN SSH1 TLN1 ZNF398 TANC1 HERC2 SNAPC4 BCL2L13 ABCA7

8.85e-041105951035748872
Pubmed

C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.

FASN HP

9.78e-041795210982846
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

JAK3 TGM1 ABCA1 RNASEL ABCA7 IL6R

1.07e-0342195619692168
Pubmed

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

OASL TRIP4

1.10e-03189527776974
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

CEP350 HERC2 USP47

1.20e-037695327542412
Pubmed

The functional interactome landscape of the human histone deacetylase family.

IPO5 RBM12B YLPM1 USP47 SFN

1.21e-0328995523752268
Pubmed

No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels.

ABCA1 APOA5

1.22e-031995220430392
Pubmed

Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

ABCA1 APOA5

1.22e-031995219148283
Pubmed

Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation.

CPQ PRCP

1.22e-031995229514215
Pubmed

Network organization of the human autophagy system.

IPO5 SEC61A2 DSC1 YLPM1 LTA4H SNAPC4

1.29e-0343795620562859
Pubmed

Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.

ABCA1 APOA5 LTA4H

1.34e-037995319056482
Pubmed

Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.

CAMK2A SFN

1.36e-032095215648052
Pubmed

Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.

ABCA1 APOA5

1.36e-032095220714348
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

IPO5 FASN SSH1 WDR97 RANBP6 NHLRC2 MTDH USP47 SFN

1.40e-0397495928675297
Pubmed

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

IPO5 FASN STARD9 TLN1 NBEA MTDH

1.48e-0344995631732153
Pubmed

SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.

TLN1 FNDC3A

1.50e-032195232591430
Pubmed

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.

FASN SFN

1.50e-032195221093383
Pubmed

Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.

IPO5 FASN RANBP6 MRPL28

1.66e-0318495423402259
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

FNIP2 IPO5 TTC7B RANBP6

1.73e-0318695433637726
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

IPO5 SEC61A2 DSC1 YLPM1 HERC2 SLIRP CERT1 MTDH USP47

1.73e-03100595919615732
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

IPO5 YLPM1 HERC2

1.77e-038795317148452
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TTLL5 NBEA TANC1

1.77e-038795312465718
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA4 ABCA7

1.80e-0514683805
GeneFamilyTransglutaminases

TGM1 TGM7

4.93e-049682773
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA WDFY4

4.93e-0496821230
GeneFamilyStAR related lipid transfer domain containing

STARD9 CERT1

1.42e-0315682759
GeneFamilyCarboxypeptidases

CPQ PRCP

2.79e-03216821321
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

FNIP2 DENND1B

3.95e-0325682504
CoexpressionFULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN

FNIP2 DMXL2 PRCP OASL LTA4H CERT1 HNMT CD163 ITPKB SECTM1

5.87e-064589410M4785
CoexpressionGSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP

RALGAPA1 DMXL2 TTC7B ZNF473 LTA4H ARMCX4 NCOA4

7.92e-06200947M5276
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

FNIP2 DMXL2 ABCA1 TTC7B WDFY4 ITGB8 CD163

2.00e-07192967733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNIP2 DMXL2 ABCA1 TLN1 IL6R CD163 SECTM1

2.46e-071989673a1707318814dabdec48f91fa6bd223f5b879653
ToppCellCOPD-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 SSH1 FNDC3A IL6R CD163

2.55e-071999671cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 ABCA1 CPQ TLN1 WDFY4 CD163

1.86e-061709669ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP350 PPP1R16B MMRN2 TANC1 CERT1 ITPKB

3.13e-061869660ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellIPF-Myeloid-Macrophage_Alveolar|IPF / Disease state, Lineage and Cell class

HP OASL LTA4H HNMT ITGB8 SECTM1

3.54e-06190966e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

IPO5 JAK3 RBM12B PRCP WDFY4 IL6R

4.24e-0619696609d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCelldistal-2-Hematologic-Alveolar_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT ITGB8 CD163

4.49e-06198966a8093144cbe3069c25a6c1f1c94218a115da8748
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DMXL2 TTC7B OASL WDFY4 ITGB8 CD163

4.49e-06198966e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCellmedial-Hematologic-Alveolar_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT ITGB8 CD163

4.49e-06198966d64f3d806594619607a72025a93b43ed4efaed01
ToppCellmedial-2-Hematologic-Alveolar_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT ITGB8 CD163

4.49e-06198966ad8b9ac155737f794bf1974c59f8143c6ef63d71
ToppCellmedial-Hematologic-Alveolar_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT ITGB8 CD163

4.49e-061989668a21f885d26959b349eb4ca027328d6cf0f1b9cf
ToppCelldistal-Hematologic-Alveolar_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT CD163 SECTM1

4.62e-061999662918967da22602404c767d948fed6c4754e53518
ToppCelldistal-3-Hematologic-Alveolar_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT CD163 SECTM1

4.62e-06199966f57ba6c711e16fe46f8ddc70223576906b3a710b
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FNIP2 DMXL2 ABCA1 LTA4H HNMT CD163

4.62e-06199966f987f48970aec46156b80656e49b9f3604f3758c
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

OASL LTA4H HNMT WDFY4 CD163 SECTM1

4.76e-062009666e50272d172b491200d9a255ed08e6d6998cfe02
ToppCellHealthy-CD4+_T_activated|World / disease group, cell group and cell class

TGM1 OASL ARMCX4 ABCD2 ITGB8

1.32e-05140965407691970ec72a3afb45e431cf48814546b8acff
ToppCellHealthy-CD4+_T_activated|Healthy / disease group, cell group and cell class

TGM1 OASL ARMCX4 ABCD2 ITGB8

1.57e-0514596545e8089fdf7d6f69b383816d8945e39fba24c873
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TTC7B ZNF473 OASL ITGB8 SECTM1

2.09e-051549656c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PPP1R16B CITED1 WDFY4 ABCA7 MGAM2

2.59e-05161965cd41abb7ae659d3d314281783a0aaad562b26037
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GRID2IP GLRA1 VWA7 SBK3

3.00e-05829647f0ee8dafc37c3628506397f88fbb98fc6420bfb
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GRID2IP GLRA1 VWA7 SBK3

3.00e-0582964c8242d273513e99107c154afb489980d11008555
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTLL5 OASL PPP1R16B TANC1 HERC2

3.09e-05167965774f3264318b002d0df5d06d41d645366038d0bf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA1 PPP1R16B ZNF783 CD163 SECTM1

3.46e-0517196587d652afbb375f8ee50e5faecf6085630cd2163c
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LTA4H NBEA PATJ DNAH5 HNMT

3.97e-051769653bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DMXL2 NCOA4 PATJ ABCD2 WDFY4

4.07e-0517796571919b5c9bfa87fdd2cd44dfa057b66ea081be5d
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 OASL HNMT WDFY4 CD163

4.30e-05179965dc03b9045510eb1bb934329646bb92dd06890ce9
ToppCellLPS_only-Myeloid-Monocytes,_Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 OASL HNMT WDFY4 CD163

4.30e-05179965330c1326ba93bb8f32559ee1cc40e357cc44ad8d
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

DMXL2 INTU ABCA1 MMP10 CD163

4.41e-051809657be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellControl-Myeloid-Alveolar_macrophages|Control / group, cell type (main and fine annotations)

DMXL2 LTA4H WDFY4 ITGB8 CD163

4.53e-051819658d2102c8c86c59a82610f26f90946b290552e666
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OASL LTA4H HNMT CD163 SECTM1

4.77e-0518396502deb595819fb864a934fd0fcaad684f1ca42964
ToppCellCOPD-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

HP OASL LTA4H ITGB8 SECTM1

4.90e-051849657fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCellE12.5-Endothelial-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JAK3 ABCA4 PRCP PPP1R16B MMRN2

5.03e-05185965e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DMXL2 ABCA1 NCOA4 PATJ ABCD2

5.03e-051859654bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCellE12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JAK3 ABCA4 PRCP PPP1R16B MMRN2

5.03e-051859650bccc424d0466f7f82baa00127c733640a2d50fb
ToppCelldroplet-Lung-LUNG-1m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 PRCP NCOA4 PATJ WDFY4

5.03e-0518596553a5218c1e6eb12daccde3d6e02f337e2586d74c
ToppCellmild-unassigned|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TGM1 PRCP YLPM1 FRS3 ARMCX4

5.16e-051869655b2e1a58916f392fa1156bf9210df528775248ff
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 NCOA4 PATJ ABCD2 WDFY4

5.56e-05189965287e59104687fe1665232c52993889f0f2c97f17
ToppCelldroplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 NCOA4 PATJ ABCD2 WDFY4

5.56e-051899656d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell368C-Myeloid-Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

OASL LTA4H HNMT CD163 SECTM1

5.56e-05189965e62355be0d136e2b7c739848022292e9c6af7392
ToppCellControl|World / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 OASL FNDC3A

5.56e-05189965fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCellAdult|World / Lineage, Cell type, age group and donor

DMXL2 FASN HP DNAH5 SFN

5.56e-051899655cd285bfad973125d46d704fec18b21266a63379
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

HP OASL LTA4H ITGB8 SECTM1

5.70e-051909652592765016f291565697265800a232b2edef3792
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

HP OASL LTA4H HNMT ITGB8

5.70e-051909659fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

FNIP2 DMXL2 WDFY4 CD163 ITPKB

5.85e-051919653b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FNIP2 DMXL2 ABCA1 ITGB8 IL6R

5.85e-051919650b296404ebad0aadb75737f8c0462ec6934fc8bb
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

DMXL2 ABCA1 HNMT WDFY4 CD163

6.14e-05193965a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

FNIP2 NBEA PATJ DNAH5 HNMT

6.14e-051939652bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellControl-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 FNDC3A IL6R

6.14e-051939652a6d531abd34df20941cf3dac4fdfb1621a1bde6
ToppCellCOVID-19-Myeloid-TRAM2|COVID-19 / Condition, Lineage and Cell class

OASL LTA4H HNMT ITGB8 SECTM1

6.30e-05194965c5bdf2b58c10dcb09797ddaf46b2e6c80d10399f
ToppCellControl-Myeloid-Macrophage|World / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 FNDC3A IL6R

6.30e-05194965c35bf04d5e7450cb6679a036fcabb1b28f409f29
ToppCellcontrol-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DMXL2 OASL HNMT CD163 SECTM1

6.45e-0519596519413dc6aa0010686cdfa0c750ef0a7a76caf308
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

DMXL2 ABCA1 CPQ WDFY4 CD163

6.45e-05195965c172c5599379c29123340621a36bfb1fc90c2115
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FNIP2 DMXL2 ABCA1 CERT1 CD163

6.45e-051959659d649ac7d2af313481069c95349efc0c68449e2b
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA1 OASL LTA4H HNMT ITGB8

6.45e-051959659e49e59a20b1bbd6167d594c33ab6bdfe2c1ebaf
ToppCell343B|World / Donor, Lineage, Cell class and subclass (all cells)

FASN HP FCN3 DNAH5 SFN

6.45e-051959652290911fde6efacfa38b985a2541322968bee42d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNIP2 DMXL2 ABCA1 HNMT CD163

6.45e-051959659168267a799bbd4111b1227754ab8173ac1a4714
ToppCellCOVID-19-Myeloid-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

FNIP2 DMXL2 ABCA1 FNDC3A CD163

6.61e-051969654929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell(7)_Monocyte|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

DMXL2 HP HNMT CD163 SECTM1

6.61e-051969650232167559dcd2d86ee8b78017cf5f2a084b2cb7
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

OASL LTA4H SLIRP HNMT SECTM1

6.61e-051969651311d5fbbead32fcc6e6b41133a84f92f461b3d9
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_venous_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PRCP PPP1R16B MMRN2 MMP10 FCN3

6.61e-0519696585b697db1c925eff8bbef9d74565c82be5a0ddcc
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNIP2 ABCA1 LTA4H WDFY4 CD163

6.77e-051979651ded28732ea5d1f9ebca0b136575103540600ff1
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OASL LTA4H HNMT CD163 SECTM1

6.77e-05197965bf0f64bd356584cd4f8ac68867604c2118067450
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 LTA4H NCOA4 CD163 SECTM1

6.77e-051979652afc23f7394d9b40bdf06527c5e6b553e1b02dca
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNIP2 DMXL2 OASL HNMT CD163

6.77e-05197965b17ac6c88dc53e54e04e8a79409d9a0de0be88dc
ToppCellNS-moderate-d_07-13-Myeloid-Non-resident_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FNIP2 DMXL2 ABCA1 IL6R CD163

6.77e-05197965774a5053f43ac7d614c127ae7363d32a3a194f63
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

JAK3 DMXL2 LTA4H CD163 SECTM1

6.77e-05197965df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell390C-Myeloid-Monocyte-CD16+_Monocyte|390C / Donor, Lineage, Cell class and subclass (all cells)

FNIP2 DMXL2 ABCA1 HNMT CD163

6.77e-0519796501f5f5c34e904cc0146e978cc05ed1cd86a41533
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNIP2 DMXL2 OASL HNMT CD163

6.77e-05197965a22c0f2ffac34635c9c8221aee778e2fc78d672b
ToppCellIPF-Myeloid-Macrophage|IPF / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 FNDC3A CD163

6.77e-05197965a2ffb33c7cad6be43cbb8ed9a91338923cc07db4
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DMXL2 LTA4H HNMT CD163 SECTM1

6.93e-0519896574591eba5dbb2d77d416309326a26be969e4ad42
ToppCelldistal-Hematologic-Alveolar_Macrophage-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP LTA4H HNMT CD163 SECTM1

6.93e-05198965cd56124ff98a194ec030588dac684535a31cb5e4
ToppCelldistal-Hematologic-Alveolar_Macrophage|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT CD163

6.93e-0519896544c9f902af6641dcee4c64c43f83a4047f1a460e
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TTC7B OASL WDFY4 ITGB8 CD163

6.93e-051989650baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCelldistal-1-Hematologic-Alveolar_Macrophage|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HP OASL LTA4H HNMT CD163

6.93e-051989658ce1e5e1b520fe9bc66b15f808c8d1172d1e478c
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FNIP2 NBEA PATJ DNAH5 HNMT

6.93e-051989655fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DMXL2 HP LTA4H HNMT CD163

6.93e-0519896570e62d815b2a0aa5327ff94d6f4d503176e007b9
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DMXL2 LTA4H HNMT MTDH CD163

6.93e-05198965f3346c26b9647a199faf3cd7ab19c3a963dbabc2
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DMXL2 ABCA1 TTC7B WDFY4 CD163

6.93e-051989650b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCelldistal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FAM184B LTA4H SLIRP HNMT CD163

6.93e-051989656aef5f5f89b508b214e1ab1876a743dedda0553b
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DMXL2 LTA4H HNMT CD163 SECTM1

6.93e-051989653e1e79bb7b13540a06956b59c6a62984efea19ee
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 HP LTA4H HNMT CD163

6.93e-0519896551c220507bb05aa6338fec494b8ecf4902437708
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FNIP2 DMXL2 HNMT IL6R CD163

6.93e-0519896576db943db8b5483754f38e4c6af7f5955cec420c
ToppCell10x5'-Liver-Myeloid_Monocytic|Liver / Manually curated celltypes from each tissue

DMXL2 LTA4H HNMT CD163 SECTM1

6.93e-05198965d0925948bf667545fb0b343e2fc80f7379e433e3
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FNIP2 NBEA PATJ DNAH5 HNMT

6.93e-051989656ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 NCOA4 HNMT CD163 SECTM1

7.10e-051999654fc03377c017209111561789226621d258291481
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMXL2 ABCA1 WDFY4 IL6R CD163

7.10e-05199965f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCellmoderate-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FNIP2 DMXL2 MTDH ITGB8 CD163

7.10e-051999653895e367a33ac0316f96a64c07574de99684f4b7
ToppCellhealthy_donor-Myeloid|healthy_donor / Disease condition, Lineage, Cell class and subclass

DMXL2 LTA4H NCOA4 CD163 SECTM1

7.10e-05199965d41994e08f7c3f5bd865b689db8f032efbe88d24
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FNIP2 DMXL2 HNMT IL6R CD163

7.10e-05199965bcf7d15b6a08b24e7dd0ce106817659cb976f833
ToppCell10x5'-bone_marrow-Myeloid_Monocytic|bone_marrow / Manually curated celltypes from each tissue

DMXL2 LTA4H HNMT CD163 SECTM1

7.10e-0519996562b0861faf173eead75678aad10d396cd0d80c2c
ToppCell10x5'-Liver-Myeloid_Monocytic-Classical_monocytes|Liver / Manually curated celltypes from each tissue

DMXL2 LTA4H HNMT CD163 SECTM1

7.10e-0519996546491e8e76aa4d7ada036946f93cf71609c85462
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMXL2 ABCA1 WDFY4 IL6R CD163

7.10e-051999655ceeed92f831d068ff4bb3994f420002338330e7
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DMXL2 LTA4H HNMT CD163 SECTM1

7.10e-0519996596dfbcf5261286f17d9718b04ebb7b288d229b52
ToppCellIPF-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

FNIP2 DMXL2 ABCA1 FNDC3A IL6R

7.10e-051999653c2b362d5e824e1a04830e70352f8818de984174
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DMXL2 NCOA4 HNMT CD163 SECTM1

7.10e-05199965f965eb89d6d023c83154276b8fded490fd89c100
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

JAK3 DMXL2 OASL WDFY4 SECTM1

7.10e-05199965841338719d042247966867ac608146395eb8c4d9
ToppCellBAL-Severe-cDC_9|Severe / Compartment, Disease Groups and Clusters

TGM1 OASL SLIRP CD163 SECTM1

7.10e-051999659bf63b6005addc926b77417f426b89c573bf40d9
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DMXL2 LTA4H HNMT CD163 SECTM1

7.10e-0519996587d513a521dd0359f4f79b01e9e97eacb0a3c6e2
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FNIP2 ABCA1 HNMT CD163 SECTM1

7.10e-051999656783d571d28eac891fcc70380f176b53f35c88ba
DrugPirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A

IPO5 RNASEL ZNF473 ZBTB48 TTLL5 FNDC3A PATJ ZNF783

1.55e-061969487226_DN
DrugRauwolscine hydrochloride [6211-32-1]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CRELD1 ABCA1 ZBTB48 CPQ TTLL5 YLPM1 OASL MMRN2

1.61e-061979486274_UP
DrugSulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A

RALGAPA1 DMXL2 ABCA1 CPQ TTLL5 HNMT ITPKB SECTM1

1.67e-061989485446_UP
Drugdidansylcadaverine

TGM1 LMLN TGM7

3.76e-068943CID000108731
Drug2,6-dichloroquinone

TGM1 PRCP LMLN

1.10e-0511943CID000012771
Drugpropanethiol

GLRA1 LTA4H

1.69e-052942ctd:C030762
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; PC3; HT_HG-U133A

CEP350 TTLL5 YLPM1 MMRN2 SNAPC4 PATJ ABCA7

1.77e-051979474477_DN
Drugaspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A

CEP350 JAK3 CRELD1 HNMT MAP3K12 ZNF783 SECTM1

1.77e-051979471629_UP
Drug5149715; Up 200; 10uM; MCF7; HT_HG-U133A_EA

CRELD1 ZNF473 TLN1 OASL FNDC3A HNMT SECTM1

1.89e-05199947890_UP
DrugApramycin [37321-09-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A

IPO5 ABCA1 RNASEL ZNF473 ZBTB48 YLPM1 PATJ

1.95e-052009474959_DN
DiseaseHDL cholesterol change measurement

ABCA1 APOA5 FNDC3A

6.23e-0524953EFO_0007805
Diseaseneutrophil percentage of granulocytes

ACTRT3 C11orf68 ZNF398 RANBP6 ITGB8 SFN

9.76e-05228956EFO_0007994
DiseaseAsthma

MMP10 DNAH5 HNMT IL6R

1.32e-0480954C0004096
Diseasecontactin-1 measurement

MUC19 MRPL28

1.53e-046952EFO_0020286
Diseasecomplex trait

DMXL2 ABCA1 APOA5 OASL MMRN2 IL6R

2.49e-04271956EFO_0010578
Diseasemeningitis

APOA5 ITPKB

5.54e-0411952MONDO_0021108
DiseaseAtherosclerosis

ABCA1 HP LTA4H

9.22e-0459953C0004153
DiseaseAtherogenesis

ABCA1 HP LTA4H

9.22e-0459953C1563937
Diseasesusceptibility to mumps measurement

PRDM11 FMOD ITPKB

1.85e-0375953EFO_0008404
Diseaseactivities of daily living score measurement

PATJ HNMT

2.07e-0321952EFO_0008451
Diseaseankylosing spondylitis

FASN SNAPC4 IL6R

3.20e-0391953EFO_0003898

Protein segments in the cluster

PeptideGeneStartEntry
QQGGWGTVFSLESEE

BCL2L13

196

Q9BXK5
GELGAARAWENLGEQ

ADAD2

76

Q8NCV1
VLWTAEEQGGVGAFQ

CPQ

331

Q9Y646
RFEEQGLGLQWSNIG

ABCA4

811

P78363
QFDGEGGWRFEQLDT

ABCD2

676

Q9UBJ2
NLTLWTADNAGEEGG

SFN

226

P31947
QGGLELCVGDQAQDW

ACTRT3

46

Q9BYD9
LFEEQGIGVQWDNLF

ABCA1

796

O95477
QLLGGVDEAWALLQG

APOA5

161

Q6Q788
VDDGNGGFVVHWLNN

DMXL2

381

Q8TDJ6
LAGNQAIGELWAAGQ

ARMCX4

1226

Q5H9R4
LLEEQGEGAQWHNVG

ABCA7

706

Q8IZY2
QQWIEFGGNAVKEGD

RBM12B

231

Q8IXT5
DGGIAWTQGEQEVLQ

JAK3

276

P52333
FNALGGWGELQNSVK

LTA4H

341

P09960
DVGGDANWQLVVEEG

CERT1

411

Q9Y5P4
GNEFWAIRGNEVQAG

MMP10

356

P09238
RAGFGNQESEFWLGN

FCN3

151

O75636
DNFGGGNTAWEEENL

CRELD1

66

Q96HD1
QEGVFDNATGLLWIA

FMOD

121

Q06828
LLWGQLFAVDSGNDV

HP

11

P00738
DNGTAEGQVFWDDGQ

MGAM2

1696

Q2M2H8
ENHNKDGGFWTVIDG

HERC2

1216

O95714
LQDAASGLQEQALGW

MMRN2

641

Q9H8L6
SGEGCGLWEENAQLQ

FAM184B

801

Q9ULE4
LENQGGVGTELNHWE

LMLN

366

Q96KR4
TAQIGEGVENSWGDL

EXOSC9

336

Q06265
IDGNENGDLLWDFLT

HNMT

231

P50135
NLWDSGQEGFGINEI

MUC19

326

Q7Z5P9
GNEGDIIWFCNNTGF

PRCP

91

P42785
GWEFVNLGDQQSFGI

IPO5

656

O00410
EGNEWLLQGQIAAGD

NHLRC2

641

Q8NBF2
LEFQGQVLQDWLGLG

OASL

476

Q15646
NFSSIQWAGEIENLG

FANCB

166

Q8NB91
WGEEVEGIQQSGLNT

INTU

291

Q9ULD6
FFNNVGGNLKGLENW

NCOA4

246

Q13772
IAAGQDLDWIDAQGA

PPP1R16B

216

Q96T49
WVFSLVLGLGQGEDN

ITGB8

31

P26012
QLRAQEEFGQGEWSE

IL6R

291

P08887
EQVENSEGTIWGQLG

GRID2IP

836

A4D2P6
IQNFVLEWDEGKGNG

FNDC3A

401

Q9Y2H6
VWESQAQQLGGEAGD

FRS3

331

O43559
QENQLTWSGNHGEGD

FNIP2

531

Q9P278
WAGVELDKPEGNNNG

CEP350

2526

Q5VT06
LDLQWVGSGAQGAVF

MAP3K12

126

Q12852
NENLTVNGGGWNEKS

MTDH

276

Q86UE4
LGDEDNWFEINQHTG

DSC1

511

Q08554
SENLQEFWDNLIGGV

FASN

16

P49327
GNGQIWAEEFQCEGH

CD163

536

Q86VB7
GGSGDQAEWNLGQDD

DENND1B

621

Q6P3S1
LDFLGDDWGLQGNRE

SBK3

301

P0C264
LGGFHERGQDWEQTQ

NIT1

126

Q86X76
HGWGELEGLQDAANI

DNAH5

181

Q8TE73
EDEQGWCQGQLQSGR

PACSIN3

396

Q9UKS6
QWQGQLAGLCGNFDL

OTOG

1106

Q6ZRI0
FLVNLLGQWADVSGG

SEC61A2

316

Q9H9S3
WVGNDFTQNAGTGLV

PLD5

456

Q8N7P1
WQEGNREDGYLSGLN

ITPKB

916

P27987
FEWQEQGAVQVADGL

GLRA1

196

P23415
NLVTGGDNGVVEVWQ

NBEA

2876

Q8NFP9
GVQNIGQTQGEGDWK

PRDM11

386

Q9NQV5
EGGANVNFQEEEGGW

RNASEL

46

Q05823
QGRHLGDTFGEDWQQ

SHC3

381

Q92529
AINAGHIQGEQGWED

TANC1

776

Q9C0D5
ENAQGSNEAWEVFRG

STARD9

3546

Q9P2P6
DFGLAIEVEGEQQAW

CAMK2A

156

Q9UQM7
IEVEGEQQAWFGFAG

CAMK2A

161

Q9UQM7
DDDGWQFVNLGDQQS

RANBP6

661

O60518
EWNASNLEELQGSGV

SSH1

321

Q8WYL5
LQNWDFGAQAGGAES

CITED1

121

Q99966
SGDVQGLQAAWEALQ

C11orf68

131

Q9H3H3
GAQLQGGSNEWEVVV

ZBTB48

221

P10074
EDFVAGLGWEVNLTN

RALGAPA1

1836

Q6GYQ0
FSRDGWQLQVQGGVA

SECTM1

86

Q8WVN6
DGRLWAGDQILEVNG

PATJ

1476

Q8NI35
ANALDDGQWSQGLIS

TLN1

2381

Q9Y490
AQVGEVALGFWGQDK

WDR97

366

A6NE52
GVNTEGLETNQWYGE

ZNF398

621

Q8TD17
SWGGNWEQGLELEGQ

ZNF774

106

Q6NX45
GTFDLVWGNGINTAD

USP47

86

Q96K76
QLFGELGLWSQGEET

WDFY4

2266

Q6ZS81
GGEGWILGQIYANND

MRPL28

81

Q13084
GLGWVQFSSEEGLRN

SLIRP

61

Q9GZT3
GLWDTNDEQGLNSEF

YLPM1

1581

P49750
WNGLGEVLQAQGNDA

TTC7B

801

Q86TV6
QLWCGDSEGDQGQLS

ZNF484

836

Q5JVG2
QEGEAATQQWLGGQR

SNAPC4

1276

Q5SXM2
SLDDNGVLIGNWSGD

TGM1

331

P22735
RIQDQEFQEGFDGGW

TRIP4

421

Q15650
EWGLDQEQVFSLGDG

ZBED1

666

O96006
NSNDDNGVLQGNWGE

TGM7

231

Q96PF1
FWQQLNEIHALGGGD

VWA7

376

Q9Y334
LGQQGEGDSWEQLRL

THSD8

31

A0A1W2PP97
LQTGGFAWEGEVENN

TTLL5

1111

Q6EMB2
LADFWGNNNEILSGL

TANGO2

36

Q6ICL3
VEFGNQLEGKWAVLG

ZNF783

86

Q6ZMS7
EQLGLEQGDTFWDTA

ZNF473

21

Q8WTR7