Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	long-chain fatty acyl-CoA hydrolase activity	ACOT1 ACOT2	9.21e-05	17	17	2	GO:0052816
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT11 GALNT9	1.28e-04	20	17	2	GO:0004653
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	ACOT1 ACOT2	2.36e-04	27	17	2	GO:0047617
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	ACOT1 ACOT2	2.55e-04	28	17	2	GO:0016289
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNT11 GALNT9	3.99e-04	35	17	2	GO:0008376
GeneOntologyMolecularFunction	thiolester hydrolase activity	ACOT1 ACOT2	7.21e-04	47	17	2	GO:0016790
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	GALNT11 GALNT9	7.36e-03	153	17	2	GO:0008194
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	ACOT1 ACOT2	7.73e-03	157	17	2	GO:0052689
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA catabolic process	ACOT1 ACOT2	1.92e-06	3	17	2	GO:0036116
GeneOntologyBiologicalProcess	fatty-acyl-CoA catabolic process	ACOT1 ACOT2	1.79e-05	8	17	2	GO:0036115
GeneOntologyBiologicalProcess	nucleoside bisphosphate catabolic process	ACOT1 ACOT2	1.08e-04	19	17	2	GO:0033869
GeneOntologyBiologicalProcess	ribonucleoside bisphosphate catabolic process	ACOT1 ACOT2	1.08e-04	19	17	2	GO:0034031
GeneOntologyBiologicalProcess	purine nucleoside bisphosphate catabolic process	ACOT1 ACOT2	1.08e-04	19	17	2	GO:0034034
GeneOntologyBiologicalProcess	fatty acid derivative catabolic process	ACOT1 ACOT2	1.46e-04	22	17	2	GO:1901569
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA metabolic process	ACOT1 ACOT2	2.22e-04	27	17	2	GO:0035336
GeneOntologyBiologicalProcess	very long-chain fatty acid metabolic process	ACOT1 ACOT2	3.74e-04	35	17	2	GO:0000038
GeneOntologyBiologicalProcess	fatty-acyl-CoA metabolic process	ACOT1 ACOT2	5.40e-04	42	17	2	GO:0035337
GeneOntologyBiologicalProcess	O-glycan processing	GALNT11 GALNT9	5.66e-04	43	17	2	GO:0016266
GeneOntologyBiologicalProcess	sulfur compound catabolic process	ACOT1 ACOT2	8.60e-04	53	17	2	GO:0044273
Domain	Thio_Ohase/aa_AcTrfase	ACOT1 ACOT2	4.67e-06	4	17	2	IPR006862
Domain	Acyl-CoA_thioEstase_long-chain	ACOT1 ACOT2	4.67e-06	4	17	2	IPR016662
Domain	Bile_Hydr_Trans	ACOT1 ACOT2	4.67e-06	4	17	2	PF04775
Domain	BAAT_C	ACOT1 ACOT2	7.79e-06	5	17	2	PF08840
Domain	BAAT_C	ACOT1 ACOT2	7.79e-06	5	17	2	IPR014940
Domain	Ricin_B_lectin	GALNT11 GALNT9	2.31e-04	25	17	2	PF00652
Domain	RICIN	GALNT11 GALNT9	2.91e-04	28	17	2	SM00458
Domain	RICIN_B_LECTIN	GALNT11 GALNT9	2.91e-04	28	17	2	PS50231
Domain	Glyco_trans_2-like	GALNT11 GALNT9	3.34e-04	30	17	2	IPR001173
Domain	Ricin_B_lectin	GALNT11 GALNT9	3.34e-04	30	17	2	IPR000772
Domain	Glycos_transf_2	GALNT11 GALNT9	3.34e-04	30	17	2	PF00535
Domain	-	GALNT11 GALNT9	2.42e-03	81	17	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	GALNT11 GALNT9	2.85e-03	88	17	2	IPR029044
Domain	-	ACOT1 ACOT2	5.14e-03	119	17	2	3.40.50.1820
Domain	AB_hydrolase	ACOT1 ACOT2	5.14e-03	119	17	2	IPR029058
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	7.10e-05	14	13	2	MM15840
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	8.19e-05	15	13	2	M39789
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	9.35e-05	16	13	2	MM15813
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	ACOT1 ACOT2	1.79e-04	22	13	2	M11673
Pathway	WP_7OXOC_AND_7BETAHC_PATHWAYS	ACOT1 ACOT2	2.72e-04	27	13	2	M40054
Pathway	KEGG_O_GLYCAN_BIOSYNTHESIS	GALNT11 GALNT9	3.37e-04	30	13	2	M6929
Pathway	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION	ACOT1 ACOT2	4.59e-04	35	13	2	MM15462
Pathway	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION	ACOT1 ACOT2	5.13e-04	37	13	2	M14690
Pathway	WP_OXYSTEROLS_DERIVED_FROM_CHOLESTEROL	ACOT1 ACOT2	9.76e-04	51	13	2	M39754
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ACOT1 ACOT2	1.01e-03	52	13	2	MM15920
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	GALNT11 GALNT9	1.35e-03	60	13	2	MM15636
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	GALNT11 GALNT9	1.44e-03	62	13	2	M546
Pathway	REACTOME_PEROXISOMAL_PROTEIN_IMPORT	ACOT1 ACOT2	1.58e-03	65	13	2	MM15628
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP153 RNF168	2.21e-03	77	13	2	M27226
Pathway	REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION	ACOT1 ACOT2	2.50e-03	82	13	2	MM17230
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP153 RNF168	2.62e-03	84	13	2	MM14929
Pubmed	Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.	ACOT1 ACOT2	2.25e-07	2	17	2	25114170
Pubmed	Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.	ACOT1 ACOT2	2.25e-07	2	17	2	11330065
Pubmed	Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.	ACOT1 ACOT2	6.74e-07	3	17	2	35215835
Pubmed	Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.	ACOT1 ACOT2	6.74e-07	3	17	2	31930115
Pubmed	Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.	ACOT1 ACOT2	6.74e-07	3	17	2	10567408
Pubmed	Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.	ACOT1 ACOT2	1.35e-06	4	17	2	15007068
Pubmed	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.	ACOT1 ACOT2	2.25e-06	5	17	2	16940157
Pubmed	Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.	ACOT1 ACOT2	2.25e-06	5	17	2	31676684
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT1 ACOT2	8.08e-06	9	17	2	16103133
Pubmed	Cloning and characterization of human karyopherin beta3.	NUP153 RPL13	8.08e-06	9	17	2	9114010
Pubmed	Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.	DDB1 RNF168	3.83e-05	19	17	2	34188037
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	ACOT1 ACOT2	4.25e-05	20	17	2	26241474
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT11 GALNT9	6.17e-05	24	17	2	31882545
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SLC4A1AP MCM3 RPL13	6.55e-05	163	17	3	22113938
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	DDB1 MCM3	7.84e-05	27	17	2	27462463
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SLC4A1AP DDB1 MCM3 NUP153 RPL13	8.57e-05	989	17	5	36424410
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	DDB1 MCM3	9.06e-05	29	17	2	24239288
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	ACOT1 ACOT2	9.06e-05	29	17	2	28364022
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	SLC4A1AP DDB1 MCM3 RPL13	1.26e-04	551	17	4	34728620
Pubmed	A cohesin-RAD21 interactome.	DDB1 MCM3 RPL13	1.35e-04	208	17	3	22145905
Pubmed	A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation.	MCM3 NUP153	1.48e-04	37	17	2	32912968
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ACOT1 GPR63 ACOT2	1.88e-04	233	17	3	37704626
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	DDB1 MCM3 RPL13	1.96e-04	236	17	3	36339263
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	DDB1 MCM3 NUP153 RPL13	2.03e-04	624	17	4	33729478
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	DDB1 NUP153 RNF168	2.32e-04	250	17	3	33536335
Pubmed	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.	ACOT1 ACOT2	2.40e-04	47	17	2	31097699
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	DDB1 MCM3 RPL13	2.54e-04	258	17	3	21081666
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	DDB1 MCM3 RPL13	2.97e-04	272	17	3	25315684
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DDB1 NUP153 NKTR RPL13 RNF168	3.01e-04	1294	17	5	30804502
Pubmed	CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.	DDB1 MCM3	3.05e-04	53	17	2	34026424
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DDB1 MCM3 NUP153 RPL13	3.28e-04	708	17	4	39231216
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	DDB1 MCM3 SVEP1 RPL13	3.39e-04	714	17	4	28302793
Pubmed	Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.	ACOT1 ACOT2	4.05e-04	61	17	2	27694478
Pubmed	Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.	DDB1 NUP153	4.88e-04	67	17	2	29357390
Cytoband	14q24.3	ACOT1 ACOT2	5.41e-04	93	17	2	14q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	ACOT1 ACOT2	2.46e-03	200	17	2	chr14q24
GeneFamily	Acyl-CoA thioesterases	ACOT1 ACOT2	2.50e-05	10	14	2	41
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT11 GALNT9	1.05e-04	20	14	2	433
Coexpression	SERVITJA_LIVER_HNF1A_TARGETS_UP	ACOT1 ACOT2 MOGAT1	9.00e-05	137	17	3	M2397
Coexpression	WENG_POR_TARGETS_LIVER_DN	ACOT1 ACOT2	9.94e-05	23	17	2	M1677
Coexpression	WENG_POR_DOSAGE	ACOT1 ACOT2	9.94e-05	23	17	2	M1634
Coexpression	WENG_POR_TARGETS_GLOBAL_DN	ACOT1 ACOT2	1.18e-04	25	17	2	M1615
Coexpression	WENG_POR_TARGETS_LIVER_DN	ACOT1 ACOT2	1.18e-04	25	17	2	MM1206
Coexpression	SERVITJA_LIVER_HNF1A_TARGETS_UP	ACOT1 ACOT2 MOGAT1	1.18e-04	150	17	3	MM936
Coexpression	WAGNER_APO2_SENSITIVITY	GALNT11 GALNT9	1.28e-04	26	17	2	M13240
Coexpression	WENG_POR_TARGETS_GLOBAL_DN	ACOT1 ACOT2	1.38e-04	27	17	2	MM1192
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_DN	SLC4A1AP GPR63 RPL13	1.65e-04	168	17	3	M2991
Coexpression	WENG_POR_DOSAGE	ACOT1 ACOT2	1.70e-04	30	17	2	MM1199
Coexpression	GSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_UP	SLC4A1AP DDB1 RPL13	2.71e-04	199	17	3	M4141
Coexpression	GSE41867_DAY8_VS_DAY15_LCMV_CLONE13_EFFECTOR_CD8_TCELL_UP	GALNT11 NKTR ACOT2	2.75e-04	200	17	3	M9449
Coexpression	OHGUCHI_LIVER_HNF4A_TARGETS_UP	ACOT1 ACOT2	4.76e-04	50	17	2	M2193
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	SLC4A1AP GALNT11 ACOT1 ACOT2	5.10e-04	600	17	4	MM1025
Computational	Neighborhood of SMC1L1	MCM3 NUP153	2.16e-04	27	9	2	GNF2_SMC1L1
Computational	Neighborhood of MLH1	MCM3 NUP153	5.27e-04	42	9	2	GNF2_MLH1
Computational	Neighborhood of HAT1	MCM3 NUP153	7.48e-04	50	9	2	GNF2_HAT1
Computational	Neighborhood of MCM5	MCM3 NUP153	1.11e-03	61	9	2	GNF2_MCM5
Disease	Disease Exacerbation	DDB1 RPL13	3.11e-03	165	15	2	C0235874
Disease	Hereditary Diffuse Gastric Cancer	DDB1 RPL13	9.47e-03	293	15	2	C1708349
Disease	Stomach Neoplasms	DDB1 RPL13	9.72e-03	297	15	2	C0038356
Disease	Malignant neoplasm of stomach	DDB1 RPL13	9.91e-03	300	15	2	C0024623
Disease	mean platelet volume	MCM3 SVEP1 GALNT9	1.37e-02	1020	15	3	EFO_0004584

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRRKPQIICYPETGH	ACOT1	346	Q86TX2
AHGRRKPQIICYPET	ACOT2	406	P49753
TYRKAIHTVVGRPIP	MOGAT1	276	Q96PD6
PCSRVAHIERTRKPY	GALNT9	371	Q9HCQ5
IPCSRVGHIFRKRRP	GALNT11	371	Q8NCW6
LVRPKVVRSVHYCPA	MCM3	136	P25205
IRYICLRRHSKPAEP	C1orf100	76	Q5SVJ3
KRRIRPSAVYVCGEH	GPR63	401	Q9BZJ6
HIRTVPLYESPRKIC	DDB1	711	Q16531
RPIVRCPTVRYHTKV	RPL13	56	P26373
CPTVRYHTKVRAGRG	RPL13	61	P26373
RKIKGRGTIRYHTPP	NKTR	331	P30414
SYCRVRTCPHLRQPK	SVEP1	431	Q4LDE5
KYCHLLVRGFRPRPS	TENT5B	281	Q96A09
IQHKRIDIRPRPYTC	ZNF749	471	O43361
SYRKVRRGRVPEPCI	ZSCAN32	316	Q9NX65
IRTRRCHQGPIKPYQ	NUP153	16	P49790
CVLSHERPKTRVPYS	RNF168	326	Q8IYW5
KTRIPPRTYCRVHVG	SLC4A1AP	246	Q9BWU0