Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein phosphatase binding	AKAP6 DLG4 FCRL5 PTPRT	8.88e-04	210	41	4	GO:0019903
GeneOntologyMolecularFunction	phosphatase binding	AKAP6 DLG4 FCRL5 PTPRT	2.06e-03	264	41	4	GO:0019902
GeneOntologyBiologicalProcess	skin epidermis development	SOX9 LAMA5 FLG HRNR FLG2	1.88e-05	166	41	5	GO:0098773
GeneOntologyBiologicalProcess	insulin receptor recycling	IDE CTSD	3.84e-05	5	41	2	GO:0038020
GeneOntologyBiologicalProcess	branching morphogenesis of an epithelial tube	SOX9 LAMA5 DDR1 KDR CTSD	4.39e-05	198	41	5	GO:0048754
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG HRNR FLG2	7.37e-05	41	41	3	GO:0061436
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	SOX9 LAMA5 DDR1 KDR CTSD	1.01e-04	236	41	5	GO:0061138
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	SOX9 LAMA5 DDR1 KDR CTSD	1.53e-04	258	41	5	GO:0001763
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	SOX9 LAMA5 ROBO1 DDR1 KDR CTSD	1.71e-04	421	41	6	GO:0060562
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	SOX9 LAMA5 ROBO1 DDR1 KDR FLG2 CTSD	1.96e-04	619	41	7	GO:0002009
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	6.98e-08	5	41	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG HRNR FLG2 PKP4	1.00e-05	69	41	4	GO:0001533
HumanPheno	Aplasia/Hypoplasia of the sternum	SOX9 LAMA5 RBM10	2.39e-05	19	16	3	HP:0006714
HumanPheno	Short 1st metacarpal	SOX9 LAMA5 ROBO1	7.10e-05	27	16	3	HP:0010034
HumanPheno	Short proximal phalanx of finger	SOX9 LAMA5 ROBO1	1.19e-04	32	16	3	HP:0010241
HumanPheno	Aplasia/Hypoplasia of the 1st metacarpal	SOX9 LAMA5 ROBO1	1.43e-04	34	16	3	HP:0010026
HumanPheno	Short phalanx of the thumb	SOX9 LAMA5 ROBO1	1.85e-04	37	16	3	HP:0009660
HumanPheno	Aplasia/Hypoplasia of the proximal phalanges of the hand	SOX9 LAMA5 ROBO1	2.17e-04	39	16	3	HP:0009851
HumanPheno	Abnormal 1st metacarpal morphology	SOX9 LAMA5 ROBO1	2.34e-04	40	16	3	HP:0010009
Domain	Filaggrin	FLG FLG2	4.70e-06	2	41	2	IPR003303
Domain	S100_CABP	FLG HRNR FLG2	2.77e-05	27	41	3	PS00303
Domain	S_100	FLG HRNR FLG2	2.77e-05	27	41	3	PF01023
Domain	S100_Ca-bd_sub	FLG HRNR FLG2	3.10e-05	28	41	3	IPR013787
Domain	S100/CaBP-9k_CS	FLG HRNR FLG2	3.10e-05	28	41	3	IPR001751
Domain	S_100	FLG HRNR FLG2	3.10e-05	28	41	3	SM01394
Domain	Galactose-bd-like	NPRL3 LAMA5 DDR1 NGLY1	5.28e-05	94	41	4	IPR008979
Domain	RRM_1	RBM14 HTATSF1 RBMXL3 RBM10	1.10e-03	208	41	4	PF00076
Domain	RRM	RBM14 HTATSF1 RBMXL3 RBM10	1.28e-03	217	41	4	SM00360
Domain	RRM_dom	RBM14 HTATSF1 RBMXL3 RBM10	1.51e-03	227	41	4	IPR000504
Domain	RRM	RBM14 HTATSF1 RBMXL3 RBM10	1.59e-03	230	41	4	PS50102
Domain	IGc2	ROBO1 KDR FCRL5 MYOM1	1.72e-03	235	41	4	SM00408
Domain	Ig_sub2	ROBO1 KDR FCRL5 MYOM1	1.72e-03	235	41	4	IPR003598
Domain	IG	ROBO1 KDR FCRL5 MYOM1 PTPRT	2.18e-03	421	41	5	SM00409
Domain	Ig_sub	ROBO1 KDR FCRL5 MYOM1 PTPRT	2.18e-03	421	41	5	IPR003599
Domain	Nucleotide-bd_a/b_plait	RBM14 HTATSF1 RBMXL3 RBM10	2.41e-03	258	41	4	IPR012677
Domain	IG_LIKE	ROBO1 KDR FCRL5 MYOM1 PTPRT	4.23e-03	491	41	5	PS50835
Domain	Ig-like_dom	ROBO1 KDR FCRL5 MYOM1 PTPRT	4.68e-03	503	41	5	IPR007110
Domain	fn3	ROBO1 MYOM1 PTPRT	5.36e-03	162	41	3	PF00041
Domain	EF_Hand_1_Ca_BS	FLG HRNR FLG2	6.64e-03	175	41	3	IPR018247
Domain	FN3	ROBO1 MYOM1 PTPRT	7.73e-03	185	41	3	SM00060
Domain	Ig_I-set	ROBO1 KDR MYOM1	8.32e-03	190	41	3	IPR013098
Domain	ig	KDR FCRL5 MYOM1	8.32e-03	190	41	3	PF00047
Domain	Immunoglobulin	KDR FCRL5 MYOM1	8.32e-03	190	41	3	IPR013151
Domain	I-set	ROBO1 KDR MYOM1	8.32e-03	190	41	3	PF07679
Domain	FN3	ROBO1 MYOM1 PTPRT	9.43e-03	199	41	3	PS50853
Domain	EF_HAND_1	FLG HRNR FLG2	1.01e-02	204	41	3	PS00018
Domain	FN3_dom	ROBO1 MYOM1 PTPRT	1.08e-02	209	41	3	IPR003961
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	1.52e-09	3	41	3	23403047
Pubmed	Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.	SOX9 LAMA5 ROBO1 DLG4	6.63e-08	33	41	4	18480165
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	RBM14 FLG HRNR FLG2 CTSD	7.63e-08	91	41	5	34445801
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	LAMA5 NGLY1 GALK1 ILF3 HRNR FLG2 CTSD RBM10	5.09e-07	613	41	8	22268729
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	ILF3 HRNR FLG2	8.42e-07	16	41	3	31823782
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	RBM14 HTATSF1 FLG ILF3 UBAP2 FLG2 CTSD	1.31e-06	477	41	7	31300519
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	1.36e-06	2	41	2	27678121
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	1.36e-06	2	41	2	24813994
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	1.99e-06	21	41	3	19601998
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	FLG GALK1 ILF3 HRNR FLG2 KCTD5 RBM10	3.69e-06	558	41	7	27591049
Pubmed	The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.	SOX9 CATSPER1	4.06e-06	3	41	2	25101494
Pubmed	Wilms tumor protein-dependent transcription of VEGF receptor 2 and hypoxia regulate expression of the testis-promoting gene Sox9 in murine embryonic gonads.	SOX9 KDR	4.06e-06	3	41	2	29042436
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	4.06e-06	3	41	2	28928464
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	4.06e-06	3	41	2	32437351
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	RBM14 HTATSF1 FLG ILF3 HRNR FLG2 RBM10	6.27e-06	605	41	7	28977666
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	ILF3 HRNR FLG2 KCTD5 RBM10	6.43e-06	223	41	5	33731348
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	HRNR FLG2 LCT CTSD	7.85e-06	107	41	4	32989256
Pubmed	Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism.	IDE CTSD	8.12e-06	4	41	2	27703010
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	FLG HRNR FLG2 CTSD KCTD5	8.82e-06	238	41	5	35864588
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	HTATSF1 KDR HRNR CTSD RBM10 PTPRT	9.41e-06	420	41	6	28065597
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	RBM14 FLG ILF3 HRNR FLG2	1.01e-05	245	41	5	35652658
Pubmed	Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.	FLG HRNR RBM10	1.06e-05	36	41	3	31669268
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	RBM14 ILF3 UBAP2 HRNR FLG2	1.35e-05	260	41	5	36199071
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	2.03e-05	6	41	2	27304082
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	ILF3 HRNR FLG2 KCTD5 RBM10	2.14e-05	286	41	5	32041737
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RBM14 FLG ILF3 HRNR FLG2 ZC3H6 RBM10 SS18L1	3.28e-05	1082	41	8	38697112
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	HRNR FLG2 RBM10	3.62e-05	54	41	3	35474131
Pubmed	Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.	LAMA5 PTPRT	3.78e-05	8	41	2	10760573
Pubmed	Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.	ROBO1 KDR	3.78e-05	8	41	2	26659946
Pubmed	Robo4 is a vascular-specific receptor that inhibits endothelial migration.	ROBO1 KDR	3.78e-05	8	41	2	12941633
Pubmed	Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.	FLG IDE HRNR	4.04e-05	56	41	3	37059927
Pubmed	KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.	SOX9 KDR	4.86e-05	9	41	2	23746980
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	FLG ILF3 HRNR FLG2 CTSD	5.29e-05	346	41	5	25324306
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBM14 HTATSF1 ILF3 RBMXL3 RBM10	5.36e-05	347	41	5	16033648
Pubmed	Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation.	SOX9 ROBO1 ZC3H6	5.48e-05	62	41	3	19463158
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	FLG HRNR CTSD	5.48e-05	62	41	3	28344315
Pubmed	Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.	HRNR FLG2 CTSD	6.03e-05	64	41	3	36636478
Pubmed	The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf.	SOX9 KDR	6.07e-05	10	41	2	19261698
Pubmed	Wnt4 is required for proper male as well as female sexual development.	SOX9 KDR	6.07e-05	10	41	2	15581876
Pubmed	SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.	RBM14 HRNR FLG2	6.61e-05	66	41	3	36095012
Pubmed	Revealing A-Raf functions through its interactome.	RBM14 HTATSF1 ILF3 HRNR	7.02e-05	187	41	4	29777862
Pubmed	Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.	KDR MYOM1	7.41e-05	11	41	2	24355925
Pubmed	Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.	SOX9 LAMA5	7.41e-05	11	41	2	33515576
Pubmed	VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.	SOX9 KDR	7.41e-05	11	41	2	34010630
Pubmed	Prdm6 controls heart development by regulating neural crest cell differentiation and migration.	SOX9 KDR	7.41e-05	11	41	2	35108221
Pubmed	Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.	SOX9 KDR	7.41e-05	11	41	2	17470636
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	HRNR CTSD KCTD5 PKP4	8.58e-05	197	41	4	23686814
Pubmed	Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.	LAMA5 KDR	8.88e-05	12	41	2	11381080
Pubmed	Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.	LAMA5 KDR	8.88e-05	12	41	2	17460146
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLG HRNR	8.88e-05	12	41	2	31406141
Pubmed	Wnt ligands signal in a cooperative manner to promote foregut organogenesis.	SOX9 KDR	8.88e-05	12	41	2	22949635
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	HTATSF1 GALK1 ILF3 UBAP2 RBM10	1.03e-04	399	41	5	35987950
Pubmed	FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.	SOX9 KDR	1.05e-04	13	41	2	17014841
Pubmed	Blimp1 regulates the transition of neonatal to adult intestinal epithelium.	SOX9 LCT	1.05e-04	13	41	2	21878906
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG HRNR	1.22e-04	14	41	2	29178343
Pubmed	A functional reference map of the RNF8 interactome in cancer.	FLG HRNR FLG2 CTSD	1.27e-04	218	41	4	35831895
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	RBM14 FLG ILF3 CTSD KCTD5	1.29e-04	418	41	5	35338135
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	ROBO1 ILF3 CTSD	1.31e-04	83	41	3	19799774
Pubmed	CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.	ROBO1 KDR	1.41e-04	15	41	2	26503042
Pubmed	The septum transversum mesenchyme induces gall bladder development.	SOX9 KDR	1.41e-04	15	41	2	23951403
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	HTATSF1 KDR UBAP2 HRNR ADGRL3	1.47e-04	430	41	5	35044719
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	LAMA5 DLG4	1.61e-04	16	41	2	30579834
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KDR ILF3 HRNR FLG2	1.66e-04	234	41	4	36243803
Pubmed	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.	KDR MYOM1	1.82e-04	17	41	2	29371594
Pubmed	Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.	LAMA5 KDR	1.82e-04	17	41	2	22306086
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	RBM14 HTATSF1 ILF3 RBM10	1.95e-04	244	41	4	29884807
Pubmed	Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.	SOX9 KDR	2.05e-04	18	41	2	23884891
Pubmed	The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.	FLG IDE CTSD	2.27e-04	100	41	3	21800051
Pubmed	Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.	SOX9 DLG4	2.29e-04	19	41	2	32579270
Pubmed	Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.	ROBO1 KDR	2.29e-04	19	41	2	21508241
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	ILF3 HRNR KCTD5 RBM10	2.34e-04	256	41	4	32698014
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	LAMA5 HTATSF1 FLG HRNR CTSD RBM10	2.40e-04	754	41	6	35906200
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	NPRL3 CTSD	2.54e-04	20	41	2	28199306
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	LAMA5 CHRDL1	2.54e-04	20	41	2	22911573
Pubmed	Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.	SOX9 LAMA5	2.54e-04	20	41	2	26033091
Pubmed	Wntless is required for peripheral lung differentiation and pulmonary vascular development.	SOX9 KDR	2.54e-04	20	41	2	23523683
Pubmed	Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.	RBM14 RBM10	2.81e-04	21	41	2	32360748
Pubmed	Cooperation of BMP and IHH signaling in interdigital cell fate determination.	SOX9 CHRDL1	2.81e-04	21	41	2	29771958
Pubmed	Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.	SOX9 KDR	3.09e-04	22	41	2	32369453
Pubmed	FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.	SOX9 KDR	3.09e-04	22	41	2	17544391
Pubmed	Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number.	SOX9 KDR	3.09e-04	22	41	2	32141129
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	RBM14 FLG HRNR FLG2	3.34e-04	281	41	4	26725010
Pubmed	p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.	SOX9 PKP4	3.38e-04	23	41	2	25523391
Pubmed	The Sox9 transcription factor determines glial fate choice in the developing spinal cord.	SOX9 KDR	3.38e-04	23	41	2	12842915
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	HTATSF1 ILF3 RBM10	3.43e-04	115	41	3	17332742
Pubmed	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.	FLG FLG2 CTSD	3.60e-04	117	41	3	36898370
Pubmed	E-cadherin is required for intestinal morphogenesis in the mouse.	SOX9 LCT	3.68e-04	24	41	2	22766025
Pubmed	Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.	SOX9 KDR	4.00e-04	25	41	2	36046192
Pubmed	Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.	SOX9 KDR	4.00e-04	25	41	2	16887829
Pubmed	BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.	SOX9 CHRDL1	4.33e-04	26	41	2	34851738
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	IDE HRNR FLG2 CTSD	4.49e-04	304	41	4	32235678
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	RBM14 ILF3 UBAP2 CTSD RBM10	4.59e-04	551	41	5	34728620
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	TMC5 PKP4	4.67e-04	27	41	2	18649358
Pubmed	In Vitro Identification of Histatin 5 Salivary Complexes.	FLG HRNR	4.67e-04	27	41	2	26544073
Pubmed	Genetic link between renal birth defects and congenital heart disease.	LAMA5 ROBO1	5.03e-04	28	41	2	27002738
Pubmed	Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.	SOX9 KDR	5.03e-04	28	41	2	17126317
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	DDR1 KDR	5.03e-04	28	41	2	18593464
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	SOX9 ROBO1	5.39e-04	29	41	2	25336744
Pubmed	Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.	SOX9 KDR	5.39e-04	29	41	2	34267243
Pubmed	HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development.	SOX9 KDR	5.78e-04	30	41	2	28538179
Interaction	CUL2 interactions	RBM14 SOX9 FLG ILF3 HRNR FLG2 CTSD ANKRD39 KCTD5	2.29e-06	591	41	9	int:CUL2
Interaction	KHDRBS2 interactions	RBM14 CATSPER1 ILF3 HRNR RBM10	6.19e-06	129	41	5	int:KHDRBS2
Cytoband	1q21.3	FLG HRNR FLG2	1.60e-04	117	41	3	1q21.3
Cytoband	Xq23	CHRDL1 RBMXL3	1.00e-03	52	41	2	Xq23
Cytoband	Ensembl 112 genes in cytogenetic band chrXq23	CHRDL1 RBMXL3	2.90e-03	89	41	2	chrXq23
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG HRNR FLG2	5.63e-03	404	41	3	chr1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr20q13	LAMA5 PTPRT SS18L1	6.35e-03	422	41	3	chr20q13
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG HRNR FLG2	1.04e-07	7	27	3	1350
GeneFamily	RNA binding motif containing	RBM14 HTATSF1 RBMXL3 RBM10	2.66e-04	213	27	4	725
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	DDR1 KDR	1.62e-03	40	27	2	321
GeneFamily	Fibronectin type III domain containing	ROBO1 MYOM1 PTPRT	1.70e-03	160	27	3	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO1 KDR MYOM1	1.73e-03	161	27	3	593
GeneFamily	Immunoglobulin like domain containing	KDR FCRL5 PTPRT	2.90e-03	193	27	3	594
GeneFamily	EF-hand domain containing	FLG HRNR FLG2	4.14e-03	219	27	3	863
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	DDR1 KDR FCRL5	2.04e-02	394	27	3	471
Coexpression	GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_DN	ZNRF1 DDR1 DLG4 UBAP2 RBM10 PKP4	4.45e-07	187	41	6	M6691
ToppCell	droplet-Limb_Muscle-Pre-Sort\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 LAMA5 CHRDL1 MYOM1 PKP4	6.46e-07	180	41	5	af2bafcd1b2082629de3ea336711add01565c4c4
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 LAMA5 CHRDL1 MYOM1 PKP4	6.46e-07	180	41	5	f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3 PKP4	9.12e-07	193	41	5	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3 PKP4	9.12e-07	193	41	5	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3 PKP4	9.35e-07	194	41	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3 PKP4	9.35e-07	194	41	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	facs-Skin-Anagen-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 DLG4 ANKRD39 ADGRL3	2.18e-06	100	41	4	97ca9cda55a05fbb4d1f5d61f847c965e014f05c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 TMC5 MYOM1	1.44e-05	161	41	4	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CATSPER1 TMC5 ZC3H6 ADGRL3	1.79e-05	170	41	4	a6fa0cab1fa829ec601fe48306b4c43c83425b04
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CATSPER1 TMC5 ZC3H6 ADGRL3	1.79e-05	170	41	4	b40255eee45eb18b5a297336d7f3845fd8f8aa3b
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|COPD / Disease state, Lineage and Cell class	SOX9 LAMA5 DDR1 KDR	2.05e-05	176	41	4	11d867bcb4f2471b4e13a5f7dc1c24286197f26d
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	LAMA5 KDR PALMD ADGRL3	2.28e-05	181	41	4	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR PALMD HRNR PKP4	2.49e-05	185	41	4	0ab1be455f2cd883c9d1522ca78112c37833352e
ToppCell	droplet-Fat-SCAT-30m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.65e-05	188	41	4	e901a9bdf00b8e91806f445af66647373bf62661
ToppCell	droplet-Fat-SCAT-30m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.65e-05	188	41	4	5cf060bb8adaefa9964187195d67993c1248ef47
ToppCell	droplet-Fat-SCAT-30m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.65e-05	188	41	4	449f9602df3c83b2110eb479a00d428d1b55b423
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.65e-05	188	41	4	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	SOX9 LAMA5 DDR1 KDR	2.71e-05	189	41	4	8030a353473da34ae92429f2d822171a2e94248f
ToppCell	facs-GAT-Fat-24m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	da2fcd4a2cc6e45c8174109d892f1424e39919a1
ToppCell	facs-GAT-Fat-24m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	e584eaccbc22aa7f7a4340ed8a2a8b45ddca93f4
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMA5 ZNRF1 KDR ADGRL3	2.76e-05	190	41	4	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.76e-05	190	41	4	a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCell	facs-GAT-Fat-24m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	3395b2ff6ffadf84cdb1b5a37a5b6be05b56c30f
ToppCell	facs-MAT-Fat-18m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	9aaa48f3aad813c87a45efdbb67d255c94f6e6a4
ToppCell	facs-MAT-Fat-18m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	34e56c5e7ea6a8f227dbaefe73cbb8818d18b523
ToppCell	facs-MAT-Fat-18m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.76e-05	190	41	4	14cdb660ad3aabcf49572173e7628d8b99dcbe6f
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.76e-05	190	41	4	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 LAMA5 MYOM1 SS18L1	2.82e-05	191	41	4	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.82e-05	191	41	4	a0018f88f7132477cc467ee15db029a585290595
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.82e-05	191	41	4	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.82e-05	191	41	4	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.88e-05	192	41	4	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	IPF-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	AKAP6 LAMA5 MYOM1 ADGRL3	2.88e-05	192	41	4	9b06c7336624ef21f8e5393725b56038a8028e57
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.88e-05	192	41	4	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KDR PALMD ADGRL3 PKP4	2.88e-05	192	41	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	facs-MAT-Fat-24m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	ba9a47e2dc01efa6d2a99b1631d4951fac2648d4
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KDR PALMD ADGRL3 PKP4	2.94e-05	193	41	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	facs-MAT-Fat-24m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	724bb613fa434add5b1c5586b629328f819fbdfe
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KDR PALMD ADGRL3 PKP4	2.94e-05	193	41	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KDR PALMD ADGRL3 PKP4	2.94e-05	193	41	4	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR PALMD ADGRL3	2.94e-05	193	41	4	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	facs-MAT-Fat-24m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	737e540c72a3cfe8dbd4c0f139f7d729a166793a
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	LAMA5 KDR PALMD ADGRL3	2.94e-05	193	41	4	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	2.94e-05	193	41	4	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KDR PALMD ADGRL3 PKP4	3.00e-05	194	41	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR ADGRL3 PKP4	3.00e-05	194	41	4	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNRF1 KDR ADGRL3 PKP4	3.00e-05	194	41	4	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 LAMA5 MYOM1 SS18L1	3.00e-05	194	41	4	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 KDR ADGRL3 PKP4	3.06e-05	195	41	4	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	facs-GAT-Fat-3m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	3.12e-05	196	41	4	b6cc1f466d45479764080d34b1daeb8243a5a9f3
ToppCell	facs-GAT-Fat-3m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	3.12e-05	196	41	4	ede6104cdfa4ee5287efcca9bbc36677cbf7a8d8
ToppCell	facs-GAT-Fat-3m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 KDR PALMD PKP4	3.12e-05	196	41	4	039044ab28c53391c34d8226fb8cf78549e63ef4
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	AKAP6 LAMA5 MYOM1 ADGRL3	3.12e-05	196	41	4	1d94cecd378a829dd8014fc086d7fca48c953a91
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	AKAP6 LAMA5 MYOM1 ADGRL3	3.12e-05	196	41	4	aacec48285bcb7ccf1b538187071885e3602cc49
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 KDR PALMD PKP4	3.18e-05	197	41	4	7caa2c86dc4d50b57a7db8f7278d1588282ad6db
ToppCell	368C-Endothelial_cells-Endothelial-A_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 KDR PALMD PKP4	3.18e-05	197	41	4	951f18f326967206adbbfc422cce9eea3d2e0854
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	KDR PALMD ADGRL3 PKP4	3.37e-05	200	41	4	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA5 KDR PALMD PKP4	3.37e-05	200	41	4	a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCell	droplet-Heart-nan-24m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR PALMD SKIDA1	1.62e-04	115	41	3	e11128262ba1e2a7053b1b6c039f1aab37d2ce27
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 PTPRT ADGRL3	2.22e-04	128	41	3	e100629f6038e32176ffcc81bd06bd175df46cef
ToppCell	ASK440-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	KDR CTSD DOCK11	3.01e-04	142	41	3	ea694a907eaa46c55665692cb830870281700e40
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 TMC5 MYOM1	3.81e-04	154	41	3	c0fe767fc9ab45b2dfa71171f2a673a4a8decbaf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 TMC5 MYOM1	3.81e-04	154	41	3	3211f003f4d1735c7cab9b6cc68af3e0bbfba35e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 TMC5 MYOM1	3.81e-04	154	41	3	4c2a7590791c2255b15dab82c3622f71f9ffd949
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHRDL1 GALK1 CATSPER1	4.11e-04	158	41	3	1635a85fc73c544028418087f36d28957dd4f458
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHRDL1 GALK1 CATSPER1	4.11e-04	158	41	3	80841dadfa53bcde36a3e486408a095f78e772eb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 PTPRT ADGRL3	4.11e-04	158	41	3	1cefb82b9bf79c687a119be568cfc15b14c6e040
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 MYOM1	4.18e-04	159	41	3	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 MYOM1 ADGRL3	4.18e-04	159	41	3	a75ab494959575143cefdaec99e7aee3f318d559
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 MYOM1 ADGRL3	4.18e-04	159	41	3	cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	SOX9 PALMD ADGRL3	4.26e-04	160	41	3	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 PALMD TMC5	4.42e-04	162	41	3	3a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX9 PALMD TMC5	4.42e-04	162	41	3	04b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 MYOM1	4.42e-04	162	41	3	82e782096f89cd03d1fdf599ba727d6f23e35e2d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 MYOM1	4.42e-04	162	41	3	6bed33b17b59812646dc6a29c1d87413bad86c11
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 MYOM1	4.42e-04	162	41	3	502ed67f6a572f10ac6e22948a1747d8214eb974
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LCT ANKRD39 SKIDA1	4.58e-04	164	41	3	d7053de88ef8e42cac6726a40e72f212659ee034
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	KDR PALMD PKP4	4.66e-04	165	41	3	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX9 LAMA5 DDR1	4.74e-04	166	41	3	006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	AKAP6 MYOM1 SKIDA1	4.74e-04	166	41	3	68e6fc7c0040bbe48a93f96ecf28afffdc626845
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SOX9 LAMA5 DDR1	4.74e-04	166	41	3	ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DLG4 GALK1 CATSPER1	4.74e-04	166	41	3	a42268a02a89fc97272e45c4cbe21acf04b7428c
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX9 KDR TMC5	4.74e-04	166	41	3	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SOX9 KDR TMC5	4.74e-04	166	41	3	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	AKAP6 GPR155 SKIDA1	5.00e-04	169	41	3	241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR PALMD PKP4	5.00e-04	169	41	3	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC5 MYOM1 PTPRT	5.00e-04	169	41	3	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 PALMD MYOM1	5.08e-04	170	41	3	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	Mild_COVID-19-Myeloid-MoAM5\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SOX9 LAMA5 DDR1	5.08e-04	170	41	3	b2daf46ab5a49590ede8f75e4240bfe6e9d8b764
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 TMC5 MYOM1	5.08e-04	170	41	3	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO1 TMC5 MYOM1	5.08e-04	170	41	3	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 ROBO1 MYOM1	5.08e-04	170	41	3	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
Disease	cystic kidney disease (implicated_via_orthology)	LAMA5 ROBO1	7.22e-05	10	38	2	DOID:2975 (implicated_via_orthology)
Disease	Malignant neoplasm of lung	SOX9 ROBO1 DDR1 PTPRT	3.74e-04	266	38	4	C0242379
Disease	Adenocarcinoma	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0001418
Disease	Carcinoma, Granular Cell	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0205644
Disease	Adenocarcinoma, Tubular	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0205642
Disease	Carcinoma, Cribriform	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0205643
Disease	Adenocarcinoma, Basal Cell	ROBO1 DDR1 KDR	4.52e-04	116	38	3	C0205641
Disease	colorectal cancer (is_implicated_in)	KDR RBM10 PTPRT	5.11e-04	121	38	3	DOID:9256 (is_implicated_in)
Disease	Ischemic stroke	FCRL5 ILF3 PTPRT ADGRL3	7.85e-04	324	38	4	HP_0002140
Disease	high grade glioma (is_marker_for)	DDR1 KDR	1.35e-03	42	38	2	DOID:3070 (is_marker_for)
Disease	colitis (biomarker_via_orthology)	KDR LCT	1.35e-03	42	38	2	DOID:0060180 (biomarker_via_orthology)
Disease	AMYOTROPHIC LATERAL SCLEROSIS 1	CTSD SS18L1	1.90e-03	50	38	2	C1862939
Disease	Respiratory Distress Syndrome, Adult	CES3 LCT	2.30e-03	55	38	2	C0035222

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYSDSGYQEAGSFHN	PKP4	151	Q99569
SSVGSYQRGISDYHS	CATSPER1	251	Q8NEC5
NDSTYDGHTVGGLQY	DDR1	211	Q08345
GNHGNSYSIASGEYL	ADGRL3	1201	Q9HAR2
YSGSQASDNEGHSED	FLG	3011	P20930
SADYDYGESGFRHSQ	FLG	3981	P20930
DSAGYTALHYASRNG	ANKRD39	61	Q53RE8
NSQGTESSLYAHGYL	RBM10	446	P98175
SYGAQAASYGAQSAA	RBM14	376	Q96PK6
SVYAVSSNHSAAYNG	PALMD	216	Q9NP74
SSNHSAAYNGTDGLA	PALMD	221	Q9NP74
SGHSEYSDSEGYSGV	FLG2	1726	Q5D862
STYGESYDHSSNAGF	LRRC34	441	Q8IZ02
GDNSLHSYADFSGAT	NGLY1	596	Q96IV0
AQAGSYEGFDQSQSH	GPR155	546	Q7Z3F1
LTEGHSGNYYCTADN	FCRL5	531	Q96RD9
YAASNTGDHADEQDG	NPRL3	46	Q12980
HYGGTATFYLSQAAD	GALK1	371	P51570
SYSGQSSSYGEQNSD	HRNR	171	Q86YZ3
YSYSRGHYESGSGQT	HRNR	331	Q86YZ3
TGRNSSINSHGVDYY	LCT	986	P09848
NVYSGFGFHSAQDSA	LAMA5	3146	O15230
EHYSNCGYSVALGTN	PTPRT	36	O14522
YQANYGFSNDGASSS	HTATSF1	71	O43719
STDKDTAYGSFQNGH	DOCK11	1216	Q5JSL3
TSKSCEYNGTTYQHG	CHRDL1	111	Q9BU40
HYGSGSLSGYLSQDT	CTSD	141	P07339
SATAGYSQFYSNGGH	ILF3	681	Q12906
AGQYNSHLYGTSVQS	DLG4	601	P78352
SIGSSYNYGNEDQAE	KCTD5	186	Q9NXV2
GSSNAFTSGEHTNYY	IDE	136	P14735
AATSYDGSALAAYGD	CES3	156	Q6UWW8
SSYSDHAANDSDFGS	SKIDA1	386	Q1XH10
QNSSSYYSHAAGQGT	SOX9	446	P48436
YDEEADNHGGSQYAS	AKAP6	1261	Q13023
SHYSSAQGGSQHYQG	SS18L1	196	O75177
HGYSTGYDDLTQGTA	UBAP2	961	Q5T6F2
STYSDDNFGNYSDDN	ZC3H6	141	P61129
SSSNSYGQSHHYGGE	RBMXL3	406	Q8N7X1
SSSNSYGQSHRYGGE	RBMXL3	536	Q8N7X1
AYSGGHDSSSQSNRY	RBMXL3	571	Q8N7X1
NAYSGGRDSSSNSYD	RBMXL3	836	Q8N7X1
SYDQNTGGSYNSSDR	ROBO1	1141	Q9Y6N7
PDYSDAENGHDYGSS	TMC5	241	Q6UXY8
SEGSNQTSGYQSGYH	KDR	1296	P35968
QTSGYQSGYHSDDTD	KDR	1301	P35968
SASDSTYAHGNGYQE	ZNRF1	91	Q8ND25
AASAYDYGSSHGLTD	MYOM1	86	P52179