Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-arginine deiminase activity	PADI4 PADI3 PADI1	2.98e-07	5	63	3	GO:0004668
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	PADI4 PADI3 PADI1	4.85e-06	11	63	3	GO:0016813
GeneOntologyMolecularFunction	ATP hydrolysis activity	TRAP1 MDN1 SPG7 LONP2 SMCHD1 KIF12 PSMC6 POLQ KIFC2	9.48e-06	441	63	9	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	TRAP1 MYH9 MDN1 SPG7 LONP2 SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.07e-05	614	63	10	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	1.45e-04	775	63	10	GO:0017111
GeneOntologyMolecularFunction	calcium-dependent protein binding	RBM22 MASP1 FCN1 GRM4	2.60e-04	98	63	4	GO:0048306
GeneOntologyMolecularFunction	ATP-dependent peptidase activity	SPG7 LONP2	2.71e-04	8	63	2	GO:0004176
GeneOntologyMolecularFunction	pyrophosphatase activity	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.75e-04	839	63	10	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.78e-04	840	63	10	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.78e-04	840	63	10	GO:0016818
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH9 KIF12 MYO18B KIFC2	5.27e-04	118	63	4	GO:0003774
GeneOntologyMolecularFunction	immunoglobulin receptor binding	FLNA ADAM15	1.98e-03	21	63	2	GO:0034987
GeneOntologyMolecularFunction	endopeptidase activity	MASP1 PRSS47P SPG7 LONP2 ADAM15 TYSND1	2.32e-03	430	63	6	GO:0004175
GeneOntologyMolecularFunction	serine-type endopeptidase activity	MASP1 PRSS47P LONP2 TYSND1	3.05e-03	190	63	4	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	MASP1 PRSS47P LONP2 TYSND1	4.15e-03	207	63	4	GO:0008236
GeneOntologyMolecularFunction	peptidase activity	MASP1 PRSS47P SPG7 LONP2 ADAM15 TYSND1 STAMBP	4.42e-03	654	63	7	GO:0008233
GeneOntologyMolecularFunction	serine hydrolase activity	MASP1 PRSS47P LONP2 TYSND1	4.51e-03	212	63	4	GO:0017171
Domain	PAD_C	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013530
Domain	Prot_Arg_deaminase_cen_dom	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013733
Domain	PAD_N	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013732
Domain	PAD	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF03068
Domain	PAD_N	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF08526
Domain	PAD_M	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF08527
Domain	PAD	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR004303
Domain	Cupredoxin	PADI4 PADI3 PADI1	4.65e-05	22	60	3	IPR008972
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	PF12881
Domain	P-loop_NTPase	MYH9 MDN1 SPG7 LONP2 RHOV KIF12 PSMC6 MYO18B POLQ KIFC2	3.38e-04	848	60	10	IPR027417
Domain	AAA	SPG7 LONP2 PSMC6	6.23e-04	52	60	3	PF00004
Domain	ATPase_AAA_core	SPG7 LONP2 PSMC6	6.96e-04	54	60	3	IPR003959
Domain	AAA+_ATPase	MDN1 SPG7 LONP2 PSMC6	1.18e-03	144	60	4	IPR003593
Domain	AAA	MDN1 SPG7 LONP2 PSMC6	1.18e-03	144	60	4	SM00382
Domain	Myosin-like_IQ_dom	MYH9 MYO18B	1.68e-03	19	60	2	IPR027401
Domain	-	MYH9 MYO18B	1.68e-03	19	60	2	4.10.270.10
Domain	-	TRAP1 SMCHD1	1.86e-03	20	60	2	3.30.565.10
Domain	HATPase_C	TRAP1 SMCHD1	2.05e-03	21	60	2	IPR003594
Domain	EGF_CA	MASP1 FBN1 EGFL7	2.67e-03	86	60	3	PF07645
Domain	AT_hook	BOD1L1 DOT1L	3.38e-03	27	60	2	SM00384
Domain	AT_hook_DNA-bd_motif	BOD1L1 DOT1L	3.38e-03	27	60	2	IPR017956
Domain	EGF_Ca-bd_CS	MASP1 FBN1 EGFL7	3.75e-03	97	60	3	IPR018097
Domain	EGF_CA	MASP1 FBN1 EGFL7	3.97e-03	99	60	3	PS01187
Domain	ASX_HYDROXYL	MASP1 FBN1 EGFL7	4.09e-03	100	60	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 FBN1 EGFL7	4.81e-03	106	60	3	IPR000152
Domain	Ribosomal_S5_D2-typ_fold	TRAP1 LONP2	5.33e-03	34	60	2	IPR020568
Domain	Myosin_head_motor_dom	MYH9 MYO18B	6.62e-03	38	60	2	IPR001609
Domain	MYOSIN_MOTOR	MYH9 MYO18B	6.62e-03	38	60	2	PS51456
Domain	Myosin_head	MYH9 MYO18B	6.62e-03	38	60	2	PF00063
Domain	MYSc	MYH9 MYO18B	6.62e-03	38	60	2	SM00242
Domain	EGF_3	MASP1 FBN1 ADAM15 EGFL7	6.87e-03	235	60	4	PS50026
Domain	EGF_CA	MASP1 FBN1 EGFL7	7.10e-03	122	60	3	SM00179
Domain	EGF-like_Ca-bd_dom	MASP1 FBN1 EGFL7	7.42e-03	124	60	3	IPR001881
Domain	Kinesin_motor_CS	KIF12 KIFC2	7.68e-03	41	60	2	IPR019821
Domain	EGF-like_dom	MASP1 FBN1 ADAM15 EGFL7	8.39e-03	249	60	4	IPR000742
Domain	t-SNARE	EXOC7 KIFC2	8.42e-03	43	60	2	IPR010989
Domain	Kinesin-like_fam	KIF12 KIFC2	8.42e-03	43	60	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF12 KIFC2	8.80e-03	44	60	2	PS00411
Domain	-	KIF12 KIFC2	8.80e-03	44	60	2	3.40.850.10
Pubmed	Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.	PADI4 PADI3 PADI1	2.26e-08	4	63	3	27929094
Pubmed	Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.	PADI4 PADI3 PADI1	2.26e-08	4	63	3	10092850
Pubmed	Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.	PADI4 PADI3 PADI1	1.13e-07	6	63	3	15087120
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	FLNA TRAP1 MYH9 PSMC6 TACC3 DCUN1D3 KHSRP BAHCC1	3.10e-06	495	63	8	28581483
Pubmed	The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone.	ACAN DOT1L	3.23e-06	2	63	2	32083237
Pubmed	Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.	PADI4 PADI3	3.23e-06	2	63	2	24901704
Pubmed	Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.	PADI3 PADI1	3.23e-06	2	63	2	15150696
Pubmed	In vivo intra-articular contrast enhanced μCT imaging of mouse knee cartilage.	ACAN DOT1L	3.23e-06	2	63	2	36436817
Pubmed	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	MASP1 FCN1	3.23e-06	2	63	2	17938215
Pubmed	The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.	PADI3 PADI1	3.23e-06	2	63	2	16091842
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 MYO18B NUP160 NDUFS1 KHSRP	8.22e-06	1425	63	12	30948266
Pubmed	TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation.	FLNA TACC3	9.68e-06	3	63	2	32156598
Pubmed	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.	PADI3 PADI1	9.68e-06	3	63	2	33741961
Pubmed	Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice.	ACAN DOT1L	9.68e-06	3	63	2	30513362
Pubmed	Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.	PADI3 PADI1	9.68e-06	3	63	2	16973334
Pubmed	Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.	PADI3 PADI1	9.68e-06	3	63	2	15675958
Pubmed	Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.	FBN1 ACAN	9.68e-06	3	63	2	29515038
Pubmed	Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.	PADI4 PADI3	9.68e-06	3	63	2	32098295
Pubmed	The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.	PADI4 PADI3	9.68e-06	3	63	2	26255191
Pubmed	Three types of mouse peptidylarginine deiminase: characterization and tissue distribution.	PADI3 PADI1	9.68e-06	3	63	2	1778991
Pubmed	Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.	PADI3 PADI1	9.68e-06	3	63	2	26616205
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	FLNA MYH9 LONP2 IFRD2 PSMC6 TYSND1 TARBP1 NUP160 NDUFS1 STAMBP	1.24e-05	1005	63	10	19615732
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNA MYH9 ADAM15 SMCHD1 PSMC6 BOD1L1 EGFL7 TYSND1 RAB11FIP1 NUP160 NDUFS1	1.93e-05	1297	63	11	33545068
Pubmed	Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.	MASP1 FCN1	1.93e-05	4	63	2	10679061
Pubmed	FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.	ACAN FOXO4	1.93e-05	4	63	2	31980519
Pubmed	PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.	PADI3 PADI1	1.93e-05	4	63	2	14579251
Pubmed	FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.	ACAN FOXO4	1.93e-05	4	63	2	29963746
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 IFRD2 PSMC6 NUP160 NDUFS1 KHSRP	2.24e-05	1318	63	11	30463901
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	FLNA MYH9 SMCHD1 PSMC6 PATJ NUP160	3.22e-05	334	63	6	30425250
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	FLNA TRAP1 MYH9 MDN1 SMCHD1 PSMC6 NDUFS1 KHSRP	4.05e-05	707	63	8	19738201
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	FLNA RBM22 TRAP1 SMCHD1 PSMC6 PATJ NUP160 NDUFS1 KHSRP	4.08e-05	922	63	9	27609421
Pubmed	Defining the membrane proteome of NK cells.	FLNA TRAP1 MYH9 MDN1 LONP2 PSMC6 TYSND1 EXOC7 KHSRP CYB5R1	4.45e-05	1168	63	10	19946888
Pubmed	Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.	MASP1 FCN1	4.82e-05	6	63	2	15950722
Pubmed	The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.	FLNA GRM4	4.82e-05	6	63	2	11943148
Pubmed	Vector-capping: a simple method for preparing a high-quality full-length cDNA library.	FLNA MYH9	4.82e-05	6	63	2	16106752
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FLNA MYH9 FBN1 MDN1 EGFL7	4.94e-05	219	63	5	31353912
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 BOD1L1 POLQ NDUFS1 KHSRP BAHCC1	5.07e-05	1442	63	11	35575683
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FLNA SMCHD1 BOD1L1 TACC3 DOT1L PATJ KHSRP	6.06e-05	549	63	7	38280479
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 KHSRP	7.00e-05	989	63	9	36424410
Pubmed	MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.	FLNA MYH9	8.98e-05	8	63	2	34131310
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	MASP1 FCN1	1.44e-04	10	63	2	21943708
Pubmed	Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin.	FLNA MYH9	1.44e-04	10	63	2	20797700
Pubmed	Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.	FLNA ACAN	1.44e-04	10	63	2	24436304
Pubmed	A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.	TACC3 KHSRP	1.44e-04	10	63	2	15851029
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	FLNA MYH9 SMCHD1 PSMC6 RAB11FIP1 NDUFS1 KHSRP	1.76e-04	652	63	7	31180492
Pubmed	Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).	FLNA MYH9	1.76e-04	11	63	2	25336651
Pubmed	OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.	FLNA MYH9	1.76e-04	11	63	2	36411454
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA MYH9 MDN1 SMCHD1 NUP160 NDUFS1 KHSRP	1.77e-04	653	63	7	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	FLNA MYH9 PSMC6 EXOC7 NUP160 NDUFS1 SLC16A10	1.84e-04	657	63	7	36180527
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	FLNA TRAP1 MYH9 PSMC6 NUP160 KHSRP	1.93e-04	463	63	6	34901782
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FLNA TRAP1 MYH9 TACC3 NDUFS1 KHSRP	2.26e-04	477	63	6	31300519
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	FLNA MYH9 MDN1 SMCHD1 NUP160 KHSRP	2.45e-04	484	63	6	31995728
Pubmed	The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.	SLC16A7 SLC16A10	2.90e-04	14	63	2	12739169
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FLNA MYH9 TACC3 RAB11FIP1 EXOC7 KHSRP	3.00e-04	503	63	6	16964243
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	FLNA TRAP1 MYH9 KHSRP	3.19e-04	179	63	4	36261009
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TRAP1 MYH9 ACAN SMCHD1 NDUFS1 KHSRP	3.34e-04	513	63	6	25798074
Pubmed	Active conformation of the p97-p47 unfoldase complex.	MYH9 PSMC6	3.34e-04	15	63	2	35552390
Pubmed	Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.	FBN1 ACAN	3.34e-04	15	63	2	36207400
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	FLNA TRAP1 MYH9 NDUFS1	3.40e-04	182	63	4	30711629
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FLNA MDN1 SMCHD1 BOD1L1 NUP160	3.44e-04	332	63	5	32786267
Pubmed	The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.	FLNA PATJ	3.81e-04	16	63	2	18824598
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	FLNA TRAP1 SMCHD1 PSMC6 NUP160 NDUFS1	4.13e-04	534	63	6	35032548
Pubmed	STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.	FLNA TRAP1 SMCHD1 NDUFS1	4.16e-04	192	63	4	32176739
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLNA MYH9 SMCHD1 RAB11FIP1 KIFC2 NUP160 KHSRP	4.22e-04	754	63	7	35906200
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	FLNA MYH9 MDN1 PSMC6 MYO18B KHSRP	4.29e-04	538	63	6	28524877
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 ACAN	4.85e-04	18	63	2	35503090
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FLNA MYH9 RAB11FIP1	5.03e-04	85	63	3	15449545
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FLNA TRAP1 MYH9 FBN1 EGFL7 TACC3	5.30e-04	560	63	6	21653829
Pubmed	Binding specificity of Toll-like receptor cytoplasmic domains.	FLNA TRAP1	5.41e-04	19	63	2	16482509
Pubmed	Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.	FLNA MYH9	5.41e-04	19	63	2	32888949
Pubmed	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.	MYH9 EXOC7	6.01e-04	20	63	2	29158485
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	FLNA TRAP1 MYH9 PSMC6 NUP160 NDUFS1 KHSRP	6.14e-04	803	63	7	36517590
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FLNA MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 KHSRP	6.41e-04	809	63	7	32129710
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TRAP1 MYH9 MDN1 SMCHD1 PSMC6 EXOC7	6.48e-04	582	63	6	20467437
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	MYH9 KHSRP	6.63e-04	21	63	2	33029523
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA RBM22 MYH9 MDN1 SMCHD1 PSMC6 NUP160 NDUFS1 KHSRP	7.09e-04	1353	63	9	29467282
Pubmed	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.	FBN1 ACAN	7.29e-04	22	63	2	27527664
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	MYH9 PSMC6 RAB11FIP1 NDUFS1 KHSRP SLC16A10	7.86e-04	604	63	6	37616343
Pubmed	Decoding the fine-scale structure of a breast cancer genome and transcriptome.	SMCHD1 STAMBP	7.97e-04	23	63	2	16461635
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA MDN1 SPG7 ZNF341 IFRD2 DOT1L KIFC2 BAHCC1	8.34e-04	1105	63	8	35748872
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	FLNA MYH9 MDN1 PSMC6 BOD1L1 EXOC7 KHSRP	8.39e-04	847	63	7	35235311
Pubmed	β-Actin mRNA interactome mapping by proximity biotinylation.	MYH9 KHSRP	8.69e-04	24	63	2	31189591
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	FLNA NDUFS1	8.69e-04	24	63	2	21080425
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	MYO18B PADI3	8.69e-04	24	63	2	32212159
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FLNA MYH9 PSMC6 EXOC7 NUP160	8.72e-04	408	63	5	33766124
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	FLNA TRAP1 KHSRP	9.05e-04	104	63	3	36055981
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF12 KIFC2	9.43e-04	25	63	2	9275178
Pubmed	Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.	FLNA MYH9	1.02e-03	26	63	2	23382103
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	LONP2 TYSND1	1.02e-03	26	63	2	30378028
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN1 ACAN	1.02e-03	26	63	2	34189436
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNA TRAP1 MDN1 PSMC6 NUP160 NDUFS1	1.04e-03	638	63	6	33239621
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNA TRAP1 MYH9 MDN1 PSMC6 PATJ EXOC7 KHSRP	1.07e-03	1149	63	8	35446349
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	FBN1 ACAN	1.10e-03	27	63	2	11518254
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	FBN1 ACAN	1.10e-03	27	63	2	35894043
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FLNA MYH9 POLQ NUP160	1.11e-03	250	63	4	33536335
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH9 MDN1 PSMC6 EXOC7 NDUFS1 KHSRP	1.12e-03	647	63	6	26618866
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	LONP2 TYSND1	1.18e-03	28	63	2	22002062
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	FLNA MYH9 SMCHD1 KHSRP	1.21e-03	256	63	4	32698014
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	FLNA TRAP1 MYH9 PSMC6	1.25e-03	258	63	4	21081666
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	SPATA31E1 ASF1B TYSND1 DOT1L STAMBP	1.35e-03	450	63	5	16751776
Interaction	DCN interactions	COL4A6 FLNA FBN1 LONP2	9.16e-06	43	62	4	int:DCN
Cytoband	1p36.13	PADI4 PADI3 PADI1	6.48e-05	56	63	3	1p36.13
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	PRSS47P SPATA31E1 NUTM2F NUTM2G	1.70e-04	200	63	4	chr9q22
GeneFamily	Peptidyl arginine deiminases	PADI4 PADI3 PADI1	1.08e-07	5	41	3	677
GeneFamily	AAA ATPases	MDN1 SPG7 LONP2 PSMC6	6.15e-06	53	41	4	413
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF12 KIFC2	4.88e-03	46	41	2	622
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	MASP1 ACAN	7.40e-03	57	41	2	1179
GeneFamily	Proteases, serine	MASP1 PRSS47P	8.98e-03	63	41	2	738
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	DPF1 FBN1 EGFL7 POLQ BAHCC1	3.69e-06	165	63	5	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SP140L ASF1B TACC3 POLQ PADI3	4.40e-06	171	63	5	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	PADI4 ASF1B FCN1 TACC3 POLQ	6.62e-06	186	63	5	e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCell	droplet-Spleen-nan-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASF1B IFRD2 EGFL7 TACC3 SLC16A10	7.34e-06	190	63	5	a273fc119baebc11020009c923beafeebb6428c9
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASF1B ADAM15 EGFL7 TACC3 POLQ	8.75e-06	197	63	5	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASF1B RHOV KIF12 DOT1L POLQ	9.19e-06	199	63	5	f0c289523957258d16135c04679db379d43d28d9
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	DPF1 PADI4 MYH9 SMCHD1 BOD1L1	9.41e-06	200	63	5	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MDN1 MYO18B EXOC7 TARBP1	6.72e-05	154	63	4	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	droplet-Fat-Gat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.37e-05	163	63	4	3d12a8ca97005308403a3ab136af483ab25f9b0e
ToppCell	droplet-Fat-Gat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.57e-05	164	63	4	c7ad946829c655038b33748dddd7d68c15489034
ToppCell	droplet-Fat-Gat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.57e-05	164	63	4	3aae702a23fbf1d36a6f18596c23e985581de815
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.78e-05	165	63	4	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B ACAN TACC3 POLQ	8.78e-05	165	63	4	eec2d327c94832d1390314c93ef6a2be4648478b
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.78e-05	165	63	4	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ACAN ZXDB BAHCC1	9.20e-05	167	63	4	4ae9f2c5df13463709ea880ab035965fd99e7626
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ACAN ZXDB BAHCC1	9.20e-05	167	63	4	4e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF341 FOXO4 KIFC2 SLC16A10	9.41e-05	168	63	4	17fb9426eeea407b26fb895b8397faca95b7552d
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF341 FOXO4 KIFC2 SLC16A10	9.41e-05	168	63	4	a61b39884851384cffd430079040546d125b2b40
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	COL4A6 ACAN NCR2 PADI1	9.41e-05	168	63	4	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 ACAN POLQ	1.01e-04	171	63	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 ACAN POLQ	1.01e-04	171	63	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASF1B TACC3 POLQ BAHCC1	1.03e-04	172	63	4	35c20de4db47dbf31c857d23c7a25cd7f95c085c
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Myeloid\|bone_marrow / Manually curated celltypes from each tissue	ASF1B EGFL7 TACC3 POLQ	1.05e-04	173	63	4	5645a3b1e805c71d5d65fc8e4edc4e13208063fc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B ADAM15 TACC3 POLQ	1.08e-04	174	63	4	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	wk_20-22-Hematologic-Myeloid-Promonocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PADI4 FCN1 TACC3 POLQ	1.10e-04	175	63	4	654299df246debe0a5b12f0d9568eb828bb94bb9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 RHOV NUTM2F	1.10e-04	175	63	4	910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 RHOV NUTM2F	1.10e-04	175	63	4	f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD7B POLQ TARBP1 KIFC2	1.15e-04	177	63	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B TACC3 DOT1L POLQ	1.20e-04	179	63	4	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPF1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	145fae2746c5212640b7b11b04a7759ba8e5c322
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPF1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	a9f1fc5973cffdbeb7d1f5c41534422d85d596ff
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|bone_marrow / Manually curated celltypes from each tissue	ASPHD1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASF1B DOT1L STAMBP OSGIN1	1.31e-04	183	63	4	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.39e-04	186	63	4	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ASF1B TACC3 POLQ	1.42e-04	187	63	4	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ASF1B TACC3 POLQ	1.42e-04	187	63	4	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PADI4 FCN1 SMCHD1 SLC16A7	1.48e-04	189	63	4	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH9 FBN1 ADAM15 EGFL7	1.48e-04	189	63	4	fccadf8efbef17b7f12291b069c71060a71b04e2
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PADI4 FCN1 SMCHD1 SLC16A7	1.51e-04	190	63	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B EGFL7 TACC3 POLQ	1.51e-04	190	63	4	31de1727822e9818652946dfb962daee77ffad68
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA PADI4 FCN1 SMCHD1	1.54e-04	191	63	4	63d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	MDN1 SPG7 BOD1L1 TACC3	1.57e-04	192	63	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.57e-04	192	63	4	c7185fbc56ffd4c62db47fc240b3207ef65db40e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA FBN1 ACAN TMEM215	1.60e-04	193	63	4	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DPF1 ASF1B TACC3 POLQ	1.60e-04	193	63	4	516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 RAB11FIP1 SAT2	1.64e-04	194	63	4	e2d0dfb92356fa7ad7008aa8ac4198e2ac5d2495
ToppCell	Monocytes-Inflammatory_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	FLNA FCN1 SLC16A7 PPM1N	1.64e-04	194	63	4	28d19105123b015f8aa25ea8e6c078f630d4ba80
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA FBN1 ACAN TMEM215	1.67e-04	195	63	4	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	Control-Classical_Monocyte-cMono_2\|Control / Disease condition and Cell class	FLNA MYH9 SMCHD1 RAB11FIP1	1.67e-04	195	63	4	0fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 RAB11FIP1 SAT2	1.70e-04	196	63	4	ad193b231ff2f7c72590fab79919c179d5d2f327
ToppCell	mild-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PADI4 MYH9 SMCHD1 BOD1L1	1.70e-04	196	63	4	9c351306b6aae68ed47d4cb1911957bf67f9e1ae
ToppCell	droplet-Tongue-nan-3m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.70e-04	196	63	4	159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FCN1 ADAM15 RAB11FIP1 SLC16A10	1.74e-04	197	63	4	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	FLNA MYH9 SMCHD1 RAB11FIP1	1.74e-04	197	63	4	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASF1B RHOV TACC3 POLQ	1.74e-04	197	63	4	0a6754a5109bec0d0de42adbfdf4db43ff60c3d2
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 SMCHD1 BOD1L1	1.77e-04	198	63	4	e76061e66f6d60f5735962aa7777dda8958caed9
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|COVID-19_Convalescent / Disease condition and Cell class	MYH9 FCN1 SMCHD1 RAB11FIP1	1.77e-04	198	63	4	f65fd9b773aeafa55e38309479954a8e41371f52
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	FLNA SP140L FCN1 SMCHD1	1.80e-04	199	63	4	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 MYH9 FCN1	1.80e-04	199	63	4	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.80e-04	199	63	4	aa30a57c0907d012942e7babdbff6ea4d01d7798
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	PADI4 ASF1B FCN1 POLQ	1.80e-04	199	63	4	961666a677589c65f733f7262822689101d39ae3
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic-monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.80e-04	199	63	4	7e5a56bb2ac441a8fa4ad0b928f9c0c82d128190
ToppCell	10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 SAT2 OSGIN1	1.80e-04	199	63	4	50a30d5ee99e51743a0dd60144fc341ff68da9af
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A6 RHOV GRM4 PADI1	1.80e-04	199	63	4	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	FBN1 RHOV IFRD2 PPM1N	1.84e-04	200	63	4	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal\|2m / Sample Type, Dataset, Time_group, and Cell type.	COL4A6 FBN1 RAB11FIP1 SLC16A10	1.84e-04	200	63	4	3b9dcc9df54fb81deb7dd4b2749b1bc746c1e563
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	FLNA MYH9 SMCHD1 BOD1L1	1.84e-04	200	63	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	FBN1 RHOV IFRD2 PPM1N	1.84e-04	200	63	4	da45a85a4667965b24ba824af871157af5b4cd19
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.84e-04	200	63	4	07197f95282ee607db17b92fea1376051e65fc50
Drug	L-Citrulline	PADI4 PADI3 PADI1	4.16e-06	12	62	3	DB00155
Drug	N-alpha-(2-carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)ornithine amide	PADI4 PADI1	7.30e-06	2	62	2	ctd:C568520
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A	ASPHD1 GRM4 PADI3 PADI1 CYB5R1 OSGIN1	1.42e-05	193	62	6	6938_UP
Drug	Clozapine [5786-21-0]; Up 200; 12.2uM; PC3; HT_HG-U133A	COL4A6 ACAN NCR2 EXOC7 SLC16A7 KHSRP	1.42e-05	193	62	6	4670_UP
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	DPF1 COL4A6 ACAN EGFL7 NUP160 PADI1	1.51e-05	195	62	6	3821_DN
Drug	6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; PC3; HT_HG-U133A	DPF1 FBN1 ASPHD1 FCN1 EGFL7 SLC16A7	1.55e-05	196	62	6	4250_UP
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; HL60; HG-U133A	TNK1 SPG7 SP140L ACAN NCR2 SLC16A7	1.60e-05	197	62	6	1578_UP
Drug	Carbimazole [22232-54-8]; Up 200; 21.4uM; HL60; HT_HG-U133A	TNK1 PADI4 FOXO4 EGFL7 NUP160 KHSRP	1.64e-05	198	62	6	2437_UP
Drug	chlorpropamide; Down 200; 100uM; MCF7; HG-U133A	SPG7 ADAM15 ACAN NCR2 GRM4 TARBP1	1.64e-05	198	62	6	144_DN
Drug	N-alpha-(2-carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)ornithine amide	PADI4 PADI1	2.18e-05	3	62	2	ctd:C568519
Drug	Mustard Gas	TNK1 FBN1 FCN1 ACAN TACC3 DOT1L RAB11FIP1 PATJ POLQ SLC16A7 KIFC2 CYB5R1 OSGIN1	5.37e-05	1341	62	13	ctd:D009151
Drug	Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; MCF7; HT_HG-U133A	ASPHD1 ASF1B TACC3 POLQ BAHCC1	1.53e-04	186	62	5	3518_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	LONP2 ADAM15 EGFL7 EXOC7 SLC16A7	1.82e-04	193	62	5	3841_DN
Drug	splitomicin; Up 200; 20uM; PC3; HG-U133A	ACAN SMCHD1 EXOC7 GRM4 SLC16A7	1.86e-04	194	62	5	661_UP
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; PC3; HT_HG-U133A	PADI4 FOXO4 PATJ GRM4 PADI1	1.86e-04	194	62	5	6710_UP
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; HL60; HG-U133A	PADI4 ACAN NCR2 SLC16A7 SLC16A10	1.86e-04	194	62	5	1369_DN
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	FBN1 NCR2 EXOC7 PADI3 PADI1	1.86e-04	194	62	5	2789_UP
Drug	Chlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; HL60; HG-U133A	PADI4 SPG7 ACAN NCR2 PADI1	1.91e-04	195	62	5	1371_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	DPF1 PADI4 ACAN FOXO4 OSGIN1	1.95e-04	196	62	5	3742_UP
Drug	Cinnarizine [298-57-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	FCN1 ACAN NCR2 KHSRP OSGIN1	1.95e-04	196	62	5	3175_UP
Drug	Gramine [87-52-5]; Up 200; 23uM; PC3; HT_HG-U133A	MASP1 ASPHD1 ACAN PATJ EXOC7	1.95e-04	196	62	5	3999_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; PC3; HT_HG-U133A	ASPHD1 FCN1 ACAN FOXO4 EGFL7	2.00e-04	197	62	5	4475_UP
Drug	Chlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A	SP140L EGFL7 PADI1 KHSRP BAHCC1	2.00e-04	197	62	5	7472_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A	SP140L ACAN NCR2 GRM4 PADI1	2.00e-04	197	62	5	1591_UP
Drug	Epirizole [18694-40-1]; Up 200; 17uM; PC3; HT_HG-U133A	DPF1 TNK1 LONP2 FOXO4 SLC16A7	2.00e-04	197	62	5	7292_UP
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	TNK1 ASPHD1 LONP2 DOT1L EXOC7	2.00e-04	197	62	5	7003_UP
Drug	Tomatidine [77-59-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TNK1 SMCHD1 EXOC7 SLC16A7 NUP160	2.05e-04	198	62	5	7166_DN
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT_HG-U133A	DPF1 FCN1 ACAN NCR2 EXOC7	2.05e-04	198	62	5	2768_UP
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	ACAN EGFL7 PADI1 KHSRP BAHCC1	2.05e-04	198	62	5	4470_UP
Drug	vinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A	LONP2 SLC16A7 NUP160 PADI1 KHSRP	2.05e-04	198	62	5	7517_DN
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TNK1 ASPHD1 NCR2 EXOC7 SLC16A7	2.05e-04	198	62	5	6925_UP
Drug	Practolol [6673-35-4]; Up 200; 15uM; PC3; HT_HG-U133A	TNK1 PADI4 EGFL7 NCR2 DOT1L	2.05e-04	198	62	5	4603_UP
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; PC3; HT_HG-U133A	MASP1 ACAN NCR2 PATJ NUP160	2.05e-04	198	62	5	5797_UP
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; HL60; HG-U133A	SPG7 ADAM15 ACAN NCR2 RAB11FIP1	2.05e-04	198	62	5	1390_DN
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HG-U133A	ACAN NCR2 EXOC7 GRM4 TARBP1	2.05e-04	198	62	5	762_DN
Drug	Racecadotril [81110-73-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	LONP2 EGFL7 PATJ EXOC7 KHSRP	2.05e-04	198	62	5	6231_UP
Drug	rotenone; Up 200; 1uM; PC3; HT_HG-U133A	DPF1 COL4A6 PATJ EXOC7 NUP160	2.05e-04	198	62	5	5948_UP
Drug	Demecarium bromide [56-94-0]; Up 200; 5.6uM; PC3; HT_HG-U133A	ACAN NCR2 PATJ GRM4 PADI1	2.10e-04	199	62	5	5795_UP
Drug	STOCK1N-28457; Up 200; 20uM; MCF7; HT_HG-U133A	LONP2 TACC3 PATJ NUP160 PADI1	2.10e-04	199	62	5	6906_UP
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; HL60; HG-U133A	TNK1 PADI4 ADAM15 ACAN PADI1	2.10e-04	199	62	5	1364_DN
Drug	Cotinine (-) [486-56-6]; Up 200; 22.6uM; HL60; HG-U133A	MASP1 LONP2 ACAN NCR2 PADI1	2.14e-04	200	62	5	2011_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A	FBN1 ACAN NCR2 EXOC7 OSGIN1	2.14e-04	200	62	5	2648_UP
Drug	Hemicholinium bromide [312-45-8]; Up 200; 7uM; HL60; HG-U133A	SPG7 ACAN SMCHD1 EXOC7 PADI1	2.14e-04	200	62	5	1601_UP
Disease	mitral valve prolapse (is_implicated_in)	FLNA FBN1	1.40e-04	9	59	2	DOID:988 (is_implicated_in)
Disease	osteoarthritis, hip, osteoarthritis, knee	KIF12 THSD7B NUP160	2.64e-04	62	59	3	EFO_0004616, EFO_1000786
Disease	Muscular Dystrophy, Facioscapulohumeral	ACAN SMCHD1	3.02e-04	13	59	2	C0238288
Disease	Disproportionate short stature	FLNA FBN1 ACAN	5.00e-04	77	59	3	C0878659
Disease	descending aortic diameter	MASP1 FBN1 DOT1L	7.38e-04	88	59	3	EFO_0021788
Disease	body weight	ZNF341 ACAN SMCHD1 THSD7B DOT1L PATJ NUTM2F SLC16A7 NUP160	8.46e-04	1261	59	9	EFO_0004338
Disease	lean body mass	ACAN EGFL7 TACC3 PATJ NUP160	9.65e-04	379	59	5	EFO_0004995
Disease	sexual dimorphism measurement	FBN1 SPG7 ZNF341 ACAN TACC3 DOT1L PATJ GRM4	1.55e-03	1106	59	8	EFO_0021796
GeneOntologyMolecularFunction	protein-arginine deiminase activity	PADI4 PADI3 PADI1	2.98e-07	5	63	3	GO:0004668
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	PADI4 PADI3 PADI1	4.85e-06	11	63	3	GO:0016813
GeneOntologyMolecularFunction	ATP hydrolysis activity	TRAP1 MDN1 SPG7 LONP2 SMCHD1 KIF12 PSMC6 POLQ KIFC2	9.48e-06	441	63	9	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	TRAP1 MYH9 MDN1 SPG7 LONP2 SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.07e-05	614	63	10	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	1.45e-04	775	63	10	GO:0017111
GeneOntologyMolecularFunction	calcium-dependent protein binding	RBM22 MASP1 FCN1 GRM4	2.60e-04	98	63	4	GO:0048306
GeneOntologyMolecularFunction	ATP-dependent peptidase activity	SPG7 LONP2	2.71e-04	8	63	2	GO:0004176
GeneOntologyMolecularFunction	pyrophosphatase activity	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.75e-04	839	63	10	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.78e-04	840	63	10	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	TRAP1 MDN1 SPG7 LONP2 RHOV SMCHD1 KIF12 PSMC6 POLQ KIFC2	2.78e-04	840	63	10	GO:0016818
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH9 KIF12 MYO18B KIFC2	5.27e-04	118	63	4	GO:0003774
GeneOntologyMolecularFunction	immunoglobulin receptor binding	FLNA ADAM15	1.98e-03	21	63	2	GO:0034987
GeneOntologyMolecularFunction	endopeptidase activity	MASP1 PRSS47P SPG7 LONP2 ADAM15 TYSND1	2.32e-03	430	63	6	GO:0004175
GeneOntologyMolecularFunction	serine-type endopeptidase activity	MASP1 PRSS47P LONP2 TYSND1	3.05e-03	190	63	4	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	MASP1 PRSS47P LONP2 TYSND1	4.15e-03	207	63	4	GO:0008236
GeneOntologyMolecularFunction	peptidase activity	MASP1 PRSS47P SPG7 LONP2 ADAM15 TYSND1 STAMBP	4.42e-03	654	63	7	GO:0008233
GeneOntologyMolecularFunction	serine hydrolase activity	MASP1 PRSS47P LONP2 TYSND1	4.51e-03	212	63	4	GO:0017171
Domain	PAD_C	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013530
Domain	Prot_Arg_deaminase_cen_dom	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013733
Domain	PAD_N	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR013732
Domain	PAD	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF03068
Domain	PAD_N	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF08526
Domain	PAD_M	PADI4 PADI3 PADI1	3.14e-07	5	60	3	PF08527
Domain	PAD	PADI4 PADI3 PADI1	3.14e-07	5	60	3	IPR004303
Domain	Cupredoxin	PADI4 PADI3 PADI1	4.65e-05	22	60	3	IPR008972
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.01e-04	5	60	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.01e-04	5	60	2	PF12881
Domain	P-loop_NTPase	MYH9 MDN1 SPG7 LONP2 RHOV KIF12 PSMC6 MYO18B POLQ KIFC2	3.38e-04	848	60	10	IPR027417
Domain	AAA	SPG7 LONP2 PSMC6	6.23e-04	52	60	3	PF00004
Domain	ATPase_AAA_core	SPG7 LONP2 PSMC6	6.96e-04	54	60	3	IPR003959
Domain	AAA+_ATPase	MDN1 SPG7 LONP2 PSMC6	1.18e-03	144	60	4	IPR003593
Domain	AAA	MDN1 SPG7 LONP2 PSMC6	1.18e-03	144	60	4	SM00382
Domain	Myosin-like_IQ_dom	MYH9 MYO18B	1.68e-03	19	60	2	IPR027401
Domain	-	MYH9 MYO18B	1.68e-03	19	60	2	4.10.270.10
Domain	-	TRAP1 SMCHD1	1.86e-03	20	60	2	3.30.565.10
Domain	HATPase_C	TRAP1 SMCHD1	2.05e-03	21	60	2	IPR003594
Domain	EGF_CA	MASP1 FBN1 EGFL7	2.67e-03	86	60	3	PF07645
Domain	AT_hook	BOD1L1 DOT1L	3.38e-03	27	60	2	SM00384
Domain	AT_hook_DNA-bd_motif	BOD1L1 DOT1L	3.38e-03	27	60	2	IPR017956
Domain	EGF_Ca-bd_CS	MASP1 FBN1 EGFL7	3.75e-03	97	60	3	IPR018097
Domain	EGF_CA	MASP1 FBN1 EGFL7	3.97e-03	99	60	3	PS01187
Domain	ASX_HYDROXYL	MASP1 FBN1 EGFL7	4.09e-03	100	60	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 FBN1 EGFL7	4.81e-03	106	60	3	IPR000152
Domain	Ribosomal_S5_D2-typ_fold	TRAP1 LONP2	5.33e-03	34	60	2	IPR020568
Domain	Myosin_head_motor_dom	MYH9 MYO18B	6.62e-03	38	60	2	IPR001609
Domain	MYOSIN_MOTOR	MYH9 MYO18B	6.62e-03	38	60	2	PS51456
Domain	Myosin_head	MYH9 MYO18B	6.62e-03	38	60	2	PF00063
Domain	MYSc	MYH9 MYO18B	6.62e-03	38	60	2	SM00242
Domain	EGF_3	MASP1 FBN1 ADAM15 EGFL7	6.87e-03	235	60	4	PS50026
Domain	EGF_CA	MASP1 FBN1 EGFL7	7.10e-03	122	60	3	SM00179
Domain	EGF-like_Ca-bd_dom	MASP1 FBN1 EGFL7	7.42e-03	124	60	3	IPR001881
Domain	Kinesin_motor_CS	KIF12 KIFC2	7.68e-03	41	60	2	IPR019821
Domain	EGF-like_dom	MASP1 FBN1 ADAM15 EGFL7	8.39e-03	249	60	4	IPR000742
Domain	t-SNARE	EXOC7 KIFC2	8.42e-03	43	60	2	IPR010989
Domain	Kinesin-like_fam	KIF12 KIFC2	8.42e-03	43	60	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF12 KIFC2	8.80e-03	44	60	2	PS00411
Domain	-	KIF12 KIFC2	8.80e-03	44	60	2	3.40.850.10
Pubmed	Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.	PADI4 PADI3 PADI1	2.26e-08	4	63	3	27929094
Pubmed	Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.	PADI4 PADI3 PADI1	2.26e-08	4	63	3	10092850
Pubmed	Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.	PADI4 PADI3 PADI1	1.13e-07	6	63	3	15087120
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	FLNA TRAP1 MYH9 PSMC6 TACC3 DCUN1D3 KHSRP BAHCC1	3.10e-06	495	63	8	28581483
Pubmed	The Role of Dot1l in Prenatal and Postnatal Murine Chondrocytes and Trabecular Bone.	ACAN DOT1L	3.23e-06	2	63	2	32083237
Pubmed	Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.	PADI4 PADI3	3.23e-06	2	63	2	24901704
Pubmed	Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.	PADI3 PADI1	3.23e-06	2	63	2	15150696
Pubmed	In vivo intra-articular contrast enhanced μCT imaging of mouse knee cartilage.	ACAN DOT1L	3.23e-06	2	63	2	36436817
Pubmed	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	MASP1 FCN1	3.23e-06	2	63	2	17938215
Pubmed	The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.	PADI3 PADI1	3.23e-06	2	63	2	16091842
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 MYO18B NUP160 NDUFS1 KHSRP	8.22e-06	1425	63	12	30948266
Pubmed	TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation.	FLNA TACC3	9.68e-06	3	63	2	32156598
Pubmed	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.	PADI3 PADI1	9.68e-06	3	63	2	33741961
Pubmed	Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice.	ACAN DOT1L	9.68e-06	3	63	2	30513362
Pubmed	Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.	PADI3 PADI1	9.68e-06	3	63	2	16973334
Pubmed	Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.	PADI3 PADI1	9.68e-06	3	63	2	15675958
Pubmed	Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.	FBN1 ACAN	9.68e-06	3	63	2	29515038
Pubmed	Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.	PADI4 PADI3	9.68e-06	3	63	2	32098295
Pubmed	The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.	PADI4 PADI3	9.68e-06	3	63	2	26255191
Pubmed	Three types of mouse peptidylarginine deiminase: characterization and tissue distribution.	PADI3 PADI1	9.68e-06	3	63	2	1778991
Pubmed	Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.	PADI3 PADI1	9.68e-06	3	63	2	26616205
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	FLNA MYH9 LONP2 IFRD2 PSMC6 TYSND1 TARBP1 NUP160 NDUFS1 STAMBP	1.24e-05	1005	63	10	19615732
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNA MYH9 ADAM15 SMCHD1 PSMC6 BOD1L1 EGFL7 TYSND1 RAB11FIP1 NUP160 NDUFS1	1.93e-05	1297	63	11	33545068
Pubmed	Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.	MASP1 FCN1	1.93e-05	4	63	2	10679061
Pubmed	FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.	ACAN FOXO4	1.93e-05	4	63	2	31980519
Pubmed	PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.	PADI3 PADI1	1.93e-05	4	63	2	14579251
Pubmed	FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.	ACAN FOXO4	1.93e-05	4	63	2	29963746
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 IFRD2 PSMC6 NUP160 NDUFS1 KHSRP	2.24e-05	1318	63	11	30463901
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	FLNA MYH9 SMCHD1 PSMC6 PATJ NUP160	3.22e-05	334	63	6	30425250
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	FLNA TRAP1 MYH9 MDN1 SMCHD1 PSMC6 NDUFS1 KHSRP	4.05e-05	707	63	8	19738201
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	FLNA RBM22 TRAP1 SMCHD1 PSMC6 PATJ NUP160 NDUFS1 KHSRP	4.08e-05	922	63	9	27609421
Pubmed	Defining the membrane proteome of NK cells.	FLNA TRAP1 MYH9 MDN1 LONP2 PSMC6 TYSND1 EXOC7 KHSRP CYB5R1	4.45e-05	1168	63	10	19946888
Pubmed	Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.	MASP1 FCN1	4.82e-05	6	63	2	15950722
Pubmed	The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.	FLNA GRM4	4.82e-05	6	63	2	11943148
Pubmed	Vector-capping: a simple method for preparing a high-quality full-length cDNA library.	FLNA MYH9	4.82e-05	6	63	2	16106752
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FLNA MYH9 FBN1 MDN1 EGFL7	4.94e-05	219	63	5	31353912
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 BOD1L1 POLQ NDUFS1 KHSRP BAHCC1	5.07e-05	1442	63	11	35575683
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FLNA SMCHD1 BOD1L1 TACC3 DOT1L PATJ KHSRP	6.06e-05	549	63	7	38280479
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNA RBM22 TRAP1 MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 KHSRP	7.00e-05	989	63	9	36424410
Pubmed	MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.	FLNA MYH9	8.98e-05	8	63	2	34131310
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	MASP1 FCN1	1.44e-04	10	63	2	21943708
Pubmed	Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin.	FLNA MYH9	1.44e-04	10	63	2	20797700
Pubmed	Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.	FLNA ACAN	1.44e-04	10	63	2	24436304
Pubmed	A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.	TACC3 KHSRP	1.44e-04	10	63	2	15851029
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	FLNA MYH9 SMCHD1 PSMC6 RAB11FIP1 NDUFS1 KHSRP	1.76e-04	652	63	7	31180492
Pubmed	Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).	FLNA MYH9	1.76e-04	11	63	2	25336651
Pubmed	OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.	FLNA MYH9	1.76e-04	11	63	2	36411454
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA MYH9 MDN1 SMCHD1 NUP160 NDUFS1 KHSRP	1.77e-04	653	63	7	22586326
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	FLNA MYH9 PSMC6 EXOC7 NUP160 NDUFS1 SLC16A10	1.84e-04	657	63	7	36180527
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	FLNA TRAP1 MYH9 PSMC6 NUP160 KHSRP	1.93e-04	463	63	6	34901782
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FLNA TRAP1 MYH9 TACC3 NDUFS1 KHSRP	2.26e-04	477	63	6	31300519
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	FLNA MYH9 MDN1 SMCHD1 NUP160 KHSRP	2.45e-04	484	63	6	31995728
Pubmed	The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.	SLC16A7 SLC16A10	2.90e-04	14	63	2	12739169
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FLNA MYH9 TACC3 RAB11FIP1 EXOC7 KHSRP	3.00e-04	503	63	6	16964243
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	FLNA TRAP1 MYH9 KHSRP	3.19e-04	179	63	4	36261009
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TRAP1 MYH9 ACAN SMCHD1 NDUFS1 KHSRP	3.34e-04	513	63	6	25798074
Pubmed	Active conformation of the p97-p47 unfoldase complex.	MYH9 PSMC6	3.34e-04	15	63	2	35552390
Pubmed	Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.	FBN1 ACAN	3.34e-04	15	63	2	36207400
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	FLNA TRAP1 MYH9 NDUFS1	3.40e-04	182	63	4	30711629
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FLNA MDN1 SMCHD1 BOD1L1 NUP160	3.44e-04	332	63	5	32786267
Pubmed	The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.	FLNA PATJ	3.81e-04	16	63	2	18824598
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	FLNA TRAP1 SMCHD1 PSMC6 NUP160 NDUFS1	4.13e-04	534	63	6	35032548
Pubmed	STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.	FLNA TRAP1 SMCHD1 NDUFS1	4.16e-04	192	63	4	32176739
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLNA MYH9 SMCHD1 RAB11FIP1 KIFC2 NUP160 KHSRP	4.22e-04	754	63	7	35906200
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	FLNA MYH9 MDN1 PSMC6 MYO18B KHSRP	4.29e-04	538	63	6	28524877
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 ACAN	4.85e-04	18	63	2	35503090
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FLNA MYH9 RAB11FIP1	5.03e-04	85	63	3	15449545
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FLNA TRAP1 MYH9 FBN1 EGFL7 TACC3	5.30e-04	560	63	6	21653829
Pubmed	Binding specificity of Toll-like receptor cytoplasmic domains.	FLNA TRAP1	5.41e-04	19	63	2	16482509
Pubmed	Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.	FLNA MYH9	5.41e-04	19	63	2	32888949
Pubmed	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.	MYH9 EXOC7	6.01e-04	20	63	2	29158485
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	FLNA TRAP1 MYH9 PSMC6 NUP160 NDUFS1 KHSRP	6.14e-04	803	63	7	36517590
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FLNA MYH9 MDN1 SMCHD1 PSMC6 BOD1L1 KHSRP	6.41e-04	809	63	7	32129710
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TRAP1 MYH9 MDN1 SMCHD1 PSMC6 EXOC7	6.48e-04	582	63	6	20467437
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	MYH9 KHSRP	6.63e-04	21	63	2	33029523
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA RBM22 MYH9 MDN1 SMCHD1 PSMC6 NUP160 NDUFS1 KHSRP	7.09e-04	1353	63	9	29467282
Pubmed	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.	FBN1 ACAN	7.29e-04	22	63	2	27527664
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	MYH9 PSMC6 RAB11FIP1 NDUFS1 KHSRP SLC16A10	7.86e-04	604	63	6	37616343
Pubmed	Decoding the fine-scale structure of a breast cancer genome and transcriptome.	SMCHD1 STAMBP	7.97e-04	23	63	2	16461635
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA MDN1 SPG7 ZNF341 IFRD2 DOT1L KIFC2 BAHCC1	8.34e-04	1105	63	8	35748872
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	FLNA MYH9 MDN1 PSMC6 BOD1L1 EXOC7 KHSRP	8.39e-04	847	63	7	35235311
Pubmed	β-Actin mRNA interactome mapping by proximity biotinylation.	MYH9 KHSRP	8.69e-04	24	63	2	31189591
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	FLNA NDUFS1	8.69e-04	24	63	2	21080425
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	MYO18B PADI3	8.69e-04	24	63	2	32212159
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FLNA MYH9 PSMC6 EXOC7 NUP160	8.72e-04	408	63	5	33766124
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	FLNA TRAP1 KHSRP	9.05e-04	104	63	3	36055981
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF12 KIFC2	9.43e-04	25	63	2	9275178
Pubmed	Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.	FLNA MYH9	1.02e-03	26	63	2	23382103
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	LONP2 TYSND1	1.02e-03	26	63	2	30378028
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN1 ACAN	1.02e-03	26	63	2	34189436
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNA TRAP1 MDN1 PSMC6 NUP160 NDUFS1	1.04e-03	638	63	6	33239621
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNA TRAP1 MYH9 MDN1 PSMC6 PATJ EXOC7 KHSRP	1.07e-03	1149	63	8	35446349
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	FBN1 ACAN	1.10e-03	27	63	2	11518254
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	FBN1 ACAN	1.10e-03	27	63	2	35894043
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FLNA MYH9 POLQ NUP160	1.11e-03	250	63	4	33536335
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH9 MDN1 PSMC6 EXOC7 NDUFS1 KHSRP	1.12e-03	647	63	6	26618866
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	LONP2 TYSND1	1.18e-03	28	63	2	22002062
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	FLNA MYH9 SMCHD1 KHSRP	1.21e-03	256	63	4	32698014
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	FLNA TRAP1 MYH9 PSMC6	1.25e-03	258	63	4	21081666
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	SPATA31E1 ASF1B TYSND1 DOT1L STAMBP	1.35e-03	450	63	5	16751776
Interaction	DCN interactions	COL4A6 FLNA FBN1 LONP2	9.16e-06	43	62	4	int:DCN
Cytoband	1p36.13	PADI4 PADI3 PADI1	6.48e-05	56	63	3	1p36.13
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	PRSS47P SPATA31E1 NUTM2F NUTM2G	1.70e-04	200	63	4	chr9q22
GeneFamily	Peptidyl arginine deiminases	PADI4 PADI3 PADI1	1.08e-07	5	41	3	677
GeneFamily	AAA ATPases	MDN1 SPG7 LONP2 PSMC6	6.15e-06	53	41	4	413
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF12 KIFC2	4.88e-03	46	41	2	622
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	MASP1 ACAN	7.40e-03	57	41	2	1179
GeneFamily	Proteases, serine	MASP1 PRSS47P	8.98e-03	63	41	2	738
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	DPF1 FBN1 EGFL7 POLQ BAHCC1	3.69e-06	165	63	5	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SP140L ASF1B TACC3 POLQ PADI3	4.40e-06	171	63	5	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	PADI4 ASF1B FCN1 TACC3 POLQ	6.62e-06	186	63	5	e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCell	droplet-Spleen-nan-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASF1B IFRD2 EGFL7 TACC3 SLC16A10	7.34e-06	190	63	5	a273fc119baebc11020009c923beafeebb6428c9
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASF1B ADAM15 EGFL7 TACC3 POLQ	8.75e-06	197	63	5	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASF1B RHOV KIF12 DOT1L POLQ	9.19e-06	199	63	5	f0c289523957258d16135c04679db379d43d28d9
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	DPF1 PADI4 MYH9 SMCHD1 BOD1L1	9.41e-06	200	63	5	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MDN1 MYO18B EXOC7 TARBP1	6.72e-05	154	63	4	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	droplet-Fat-Gat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.37e-05	163	63	4	3d12a8ca97005308403a3ab136af483ab25f9b0e
ToppCell	droplet-Fat-Gat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.57e-05	164	63	4	c7ad946829c655038b33748dddd7d68c15489034
ToppCell	droplet-Fat-Gat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.57e-05	164	63	4	3aae702a23fbf1d36a6f18596c23e985581de815
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.78e-05	165	63	4	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B ACAN TACC3 POLQ	8.78e-05	165	63	4	eec2d327c94832d1390314c93ef6a2be4648478b
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PADI4 RHOV RAB11FIP1 OSGIN1	8.78e-05	165	63	4	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ACAN ZXDB BAHCC1	9.20e-05	167	63	4	4ae9f2c5df13463709ea880ab035965fd99e7626
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA ACAN ZXDB BAHCC1	9.20e-05	167	63	4	4e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF341 FOXO4 KIFC2 SLC16A10	9.41e-05	168	63	4	17fb9426eeea407b26fb895b8397faca95b7552d
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF341 FOXO4 KIFC2 SLC16A10	9.41e-05	168	63	4	a61b39884851384cffd430079040546d125b2b40
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	COL4A6 ACAN NCR2 PADI1	9.41e-05	168	63	4	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 ACAN POLQ	1.01e-04	171	63	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 ACAN POLQ	1.01e-04	171	63	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASF1B TACC3 POLQ BAHCC1	1.03e-04	172	63	4	35c20de4db47dbf31c857d23c7a25cd7f95c085c
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Myeloid\|bone_marrow / Manually curated celltypes from each tissue	ASF1B EGFL7 TACC3 POLQ	1.05e-04	173	63	4	5645a3b1e805c71d5d65fc8e4edc4e13208063fc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B ADAM15 TACC3 POLQ	1.08e-04	174	63	4	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	wk_20-22-Hematologic-Myeloid-Promonocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PADI4 FCN1 TACC3 POLQ	1.10e-04	175	63	4	654299df246debe0a5b12f0d9568eb828bb94bb9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 RHOV NUTM2F	1.10e-04	175	63	4	910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPF1 FBN1 RHOV NUTM2F	1.10e-04	175	63	4	f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD7B POLQ TARBP1 KIFC2	1.15e-04	177	63	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B TACC3 DOT1L POLQ	1.20e-04	179	63	4	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPF1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	145fae2746c5212640b7b11b04a7759ba8e5c322
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPF1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	a9f1fc5973cffdbeb7d1f5c41534422d85d596ff
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|bone_marrow / Manually curated celltypes from each tissue	ASPHD1 ASF1B TACC3 POLQ	1.25e-04	181	63	4	ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASF1B DOT1L STAMBP OSGIN1	1.31e-04	183	63	4	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.39e-04	186	63	4	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ASF1B TACC3 POLQ	1.42e-04	187	63	4	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 ASF1B TACC3 POLQ	1.42e-04	187	63	4	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PADI4 FCN1 SMCHD1 SLC16A7	1.48e-04	189	63	4	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH9 FBN1 ADAM15 EGFL7	1.48e-04	189	63	4	fccadf8efbef17b7f12291b069c71060a71b04e2
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	PADI4 FCN1 SMCHD1 SLC16A7	1.51e-04	190	63	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASF1B EGFL7 TACC3 POLQ	1.51e-04	190	63	4	31de1727822e9818652946dfb962daee77ffad68
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA PADI4 FCN1 SMCHD1	1.54e-04	191	63	4	63d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	MDN1 SPG7 BOD1L1 TACC3	1.57e-04	192	63	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.57e-04	192	63	4	c7185fbc56ffd4c62db47fc240b3207ef65db40e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA FBN1 ACAN TMEM215	1.60e-04	193	63	4	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DPF1 ASF1B TACC3 POLQ	1.60e-04	193	63	4	516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 RAB11FIP1 SAT2	1.64e-04	194	63	4	e2d0dfb92356fa7ad7008aa8ac4198e2ac5d2495
ToppCell	Monocytes-Inflammatory_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	FLNA FCN1 SLC16A7 PPM1N	1.64e-04	194	63	4	28d19105123b015f8aa25ea8e6c078f630d4ba80
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA FBN1 ACAN TMEM215	1.67e-04	195	63	4	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	Control-Classical_Monocyte-cMono_2\|Control / Disease condition and Cell class	FLNA MYH9 SMCHD1 RAB11FIP1	1.67e-04	195	63	4	0fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 RAB11FIP1 SAT2	1.70e-04	196	63	4	ad193b231ff2f7c72590fab79919c179d5d2f327
ToppCell	mild-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PADI4 MYH9 SMCHD1 BOD1L1	1.70e-04	196	63	4	9c351306b6aae68ed47d4cb1911957bf67f9e1ae
ToppCell	droplet-Tongue-nan-3m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOV RAB11FIP1 PPM1N PADI1	1.70e-04	196	63	4	159061fd0961b2cfb5941d403acc5b395dd0d3a0
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FCN1 ADAM15 RAB11FIP1 SLC16A10	1.74e-04	197	63	4	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	FLNA MYH9 SMCHD1 RAB11FIP1	1.74e-04	197	63	4	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASF1B RHOV TACC3 POLQ	1.74e-04	197	63	4	0a6754a5109bec0d0de42adbfdf4db43ff60c3d2
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 SMCHD1 BOD1L1	1.77e-04	198	63	4	e76061e66f6d60f5735962aa7777dda8958caed9
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|COVID-19_Convalescent / Disease condition and Cell class	MYH9 FCN1 SMCHD1 RAB11FIP1	1.77e-04	198	63	4	f65fd9b773aeafa55e38309479954a8e41371f52
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	FLNA SP140L FCN1 SMCHD1	1.80e-04	199	63	4	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 MYH9 FCN1	1.80e-04	199	63	4	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.80e-04	199	63	4	aa30a57c0907d012942e7babdbff6ea4d01d7798
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	PADI4 ASF1B FCN1 POLQ	1.80e-04	199	63	4	961666a677589c65f733f7262822689101d39ae3
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic-monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.80e-04	199	63	4	7e5a56bb2ac441a8fa4ad0b928f9c0c82d128190
ToppCell	10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PADI4 FCN1 SAT2 OSGIN1	1.80e-04	199	63	4	50a30d5ee99e51743a0dd60144fc341ff68da9af
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A6 RHOV GRM4 PADI1	1.80e-04	199	63	4	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	FBN1 RHOV IFRD2 PPM1N	1.84e-04	200	63	4	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal\|2m / Sample Type, Dataset, Time_group, and Cell type.	COL4A6 FBN1 RAB11FIP1 SLC16A10	1.84e-04	200	63	4	3b9dcc9df54fb81deb7dd4b2749b1bc746c1e563
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	FLNA MYH9 SMCHD1 BOD1L1	1.84e-04	200	63	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	FBN1 RHOV IFRD2 PPM1N	1.84e-04	200	63	4	da45a85a4667965b24ba824af871157af5b4cd19
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FLNA PADI4 FCN1 SAT2	1.84e-04	200	63	4	07197f95282ee607db17b92fea1376051e65fc50
Drug	L-Citrulline	PADI4 PADI3 PADI1	4.16e-06	12	62	3	DB00155
Drug	N-alpha-(2-carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)ornithine amide	PADI4 PADI1	7.30e-06	2	62	2	ctd:C568520
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A	ASPHD1 GRM4 PADI3 PADI1 CYB5R1 OSGIN1	1.42e-05	193	62	6	6938_UP
Drug	Clozapine [5786-21-0]; Up 200; 12.2uM; PC3; HT_HG-U133A	COL4A6 ACAN NCR2 EXOC7 SLC16A7 KHSRP	1.42e-05	193	62	6	4670_UP
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	DPF1 COL4A6 ACAN EGFL7 NUP160 PADI1	1.51e-05	195	62	6	3821_DN
Drug	6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; PC3; HT_HG-U133A	DPF1 FBN1 ASPHD1 FCN1 EGFL7 SLC16A7	1.55e-05	196	62	6	4250_UP
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; HL60; HG-U133A	TNK1 SPG7 SP140L ACAN NCR2 SLC16A7	1.60e-05	197	62	6	1578_UP
Drug	Carbimazole [22232-54-8]; Up 200; 21.4uM; HL60; HT_HG-U133A	TNK1 PADI4 FOXO4 EGFL7 NUP160 KHSRP	1.64e-05	198	62	6	2437_UP
Drug	chlorpropamide; Down 200; 100uM; MCF7; HG-U133A	SPG7 ADAM15 ACAN NCR2 GRM4 TARBP1	1.64e-05	198	62	6	144_DN
Drug	N-alpha-(2-carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)ornithine amide	PADI4 PADI1	2.18e-05	3	62	2	ctd:C568519
Drug	Mustard Gas	TNK1 FBN1 FCN1 ACAN TACC3 DOT1L RAB11FIP1 PATJ POLQ SLC16A7 KIFC2 CYB5R1 OSGIN1	5.37e-05	1341	62	13	ctd:D009151
Drug	Pyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; MCF7; HT_HG-U133A	ASPHD1 ASF1B TACC3 POLQ BAHCC1	1.53e-04	186	62	5	3518_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	LONP2 ADAM15 EGFL7 EXOC7 SLC16A7	1.82e-04	193	62	5	3841_DN
Drug	splitomicin; Up 200; 20uM; PC3; HG-U133A	ACAN SMCHD1 EXOC7 GRM4 SLC16A7	1.86e-04	194	62	5	661_UP
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; PC3; HT_HG-U133A	PADI4 FOXO4 PATJ GRM4 PADI1	1.86e-04	194	62	5	6710_UP
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; HL60; HG-U133A	PADI4 ACAN NCR2 SLC16A7 SLC16A10	1.86e-04	194	62	5	1369_DN
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	FBN1 NCR2 EXOC7 PADI3 PADI1	1.86e-04	194	62	5	2789_UP
Drug	Chlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; HL60; HG-U133A	PADI4 SPG7 ACAN NCR2 PADI1	1.91e-04	195	62	5	1371_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	DPF1 PADI4 ACAN FOXO4 OSGIN1	1.95e-04	196	62	5	3742_UP
Drug	Cinnarizine [298-57-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	FCN1 ACAN NCR2 KHSRP OSGIN1	1.95e-04	196	62	5	3175_UP
Drug	Gramine [87-52-5]; Up 200; 23uM; PC3; HT_HG-U133A	MASP1 ASPHD1 ACAN PATJ EXOC7	1.95e-04	196	62	5	3999_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; PC3; HT_HG-U133A	ASPHD1 FCN1 ACAN FOXO4 EGFL7	2.00e-04	197	62	5	4475_UP
Drug	Chlorphensin carbamate [886-74-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A	SP140L EGFL7 PADI1 KHSRP BAHCC1	2.00e-04	197	62	5	7472_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A	SP140L ACAN NCR2 GRM4 PADI1	2.00e-04	197	62	5	1591_UP
Drug	Epirizole [18694-40-1]; Up 200; 17uM; PC3; HT_HG-U133A	DPF1 TNK1 LONP2 FOXO4 SLC16A7	2.00e-04	197	62	5	7292_UP
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	TNK1 ASPHD1 LONP2 DOT1L EXOC7	2.00e-04	197	62	5	7003_UP
Drug	Tomatidine [77-59-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TNK1 SMCHD1 EXOC7 SLC16A7 NUP160	2.05e-04	198	62	5	7166_DN
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT_HG-U133A	DPF1 FCN1 ACAN NCR2 EXOC7	2.05e-04	198	62	5	2768_UP
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	ACAN EGFL7 PADI1 KHSRP BAHCC1	2.05e-04	198	62	5	4470_UP
Drug	vinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A	LONP2 SLC16A7 NUP160 PADI1 KHSRP	2.05e-04	198	62	5	7517_DN
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TNK1 ASPHD1 NCR2 EXOC7 SLC16A7	2.05e-04	198	62	5	6925_UP
Drug	Practolol [6673-35-4]; Up 200; 15uM; PC3; HT_HG-U133A	TNK1 PADI4 EGFL7 NCR2 DOT1L	2.05e-04	198	62	5	4603_UP
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; PC3; HT_HG-U133A	MASP1 ACAN NCR2 PATJ NUP160	2.05e-04	198	62	5	5797_UP
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; HL60; HG-U133A	SPG7 ADAM15 ACAN NCR2 RAB11FIP1	2.05e-04	198	62	5	1390_DN
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HG-U133A	ACAN NCR2 EXOC7 GRM4 TARBP1	2.05e-04	198	62	5	762_DN
Drug	Racecadotril [81110-73-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	LONP2 EGFL7 PATJ EXOC7 KHSRP	2.05e-04	198	62	5	6231_UP
Drug	rotenone; Up 200; 1uM; PC3; HT_HG-U133A	DPF1 COL4A6 PATJ EXOC7 NUP160	2.05e-04	198	62	5	5948_UP
Drug	Demecarium bromide [56-94-0]; Up 200; 5.6uM; PC3; HT_HG-U133A	ACAN NCR2 PATJ GRM4 PADI1	2.10e-04	199	62	5	5795_UP
Drug	STOCK1N-28457; Up 200; 20uM; MCF7; HT_HG-U133A	LONP2 TACC3 PATJ NUP160 PADI1	2.10e-04	199	62	5	6906_UP
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; HL60; HG-U133A	TNK1 PADI4 ADAM15 ACAN PADI1	2.10e-04	199	62	5	1364_DN
Drug	Cotinine (-) [486-56-6]; Up 200; 22.6uM; HL60; HG-U133A	MASP1 LONP2 ACAN NCR2 PADI1	2.14e-04	200	62	5	2011_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A	FBN1 ACAN NCR2 EXOC7 OSGIN1	2.14e-04	200	62	5	2648_UP
Drug	Hemicholinium bromide [312-45-8]; Up 200; 7uM; HL60; HG-U133A	SPG7 ACAN SMCHD1 EXOC7 PADI1	2.14e-04	200	62	5	1601_UP
Disease	mitral valve prolapse (is_implicated_in)	FLNA FBN1	1.40e-04	9	59	2	DOID:988 (is_implicated_in)
Disease	osteoarthritis, hip, osteoarthritis, knee	KIF12 THSD7B NUP160	2.64e-04	62	59	3	EFO_0004616, EFO_1000786
Disease	Muscular Dystrophy, Facioscapulohumeral	ACAN SMCHD1	3.02e-04	13	59	2	C0238288
Disease	Disproportionate short stature	FLNA FBN1 ACAN	5.00e-04	77	59	3	C0878659
Disease	descending aortic diameter	MASP1 FBN1 DOT1L	7.38e-04	88	59	3	EFO_0021788
Disease	body weight	ZNF341 ACAN SMCHD1 THSD7B DOT1L PATJ NUTM2F SLC16A7 NUP160	8.46e-04	1261	59	9	EFO_0004338
Disease	lean body mass	ACAN EGFL7 TACC3 PATJ NUP160	9.65e-04	379	59	5	EFO_0004995
Disease	sexual dimorphism measurement	FBN1 SPG7 ZNF341 ACAN TACC3 DOT1L PATJ GRM4	1.55e-03	1106	59	8	EFO_0021796

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGPDGLCPLQDKAPR	BAHCC1	371	Q9P281
GLPGSKGITLPCIIP	COL4A6	646	Q14031
ADGTLCVPKGGPPRV	EGFL7	171	Q9UHF1
PLLTLPGTACGPGLV	ADAM15	626	Q13444
CEAPLKKEGGLPEGP	DPF1	101	Q92782
CGSGGPPIITKPERV	GRM4	136	Q14833
EGGLPLCGPTDKTPL	DOT1L	1391	Q8TEK3
VPPCGKPGGDILVNG	DCUN1D3	41	Q8IWE4
SGIKLEPVPGLPGAL	RBM22	321	Q9NW64
PVLVRDGKPCLGPGP	NKX2-6	211	A6NCS4
LGIPKPYGPIINGRC	PADI1	596	Q9ULC6
LGIPKPFGPVINGRC	PADI4	596	Q9UM07
CGVVLPGQLPAPGEL	MDN1	271	Q9NU22
LKGPILCFVGPPGVG	LONP2	366	Q86WA8
GPAAPIALVPVFCGL	NCR2	186	O95944
PSVDPGEPPVGGKLC	KIF12	246	Q96FN5
LGLKIPPGCELVVGG	ASPHD1	316	Q5U4P2
PGLPKGVTCPGVKAE	C9orf131	746	Q5VYM1
GVGLCPKPLEAPGPS	FOXO4	411	P98177
IPDLPPGGGLDCKAT	PPM1N	376	Q8N819
VECGPVLLGPPLAGK	SLC16A7	381	O60669
CIDLIEKPAGPPGIL	MYH9	511	P35579
HLGIPKPFGPIINGC	PADI3	596	Q9ULW8
KGGSNLIPLEGLLPC	EXOC7	291	Q9UPT5
IVTPRPACGGDKPGV	ACAN	636	P16112
KLTILRGCPGLPGAP	FCN1	46	O00602
ILAPPESLCGGKPSG	BOD1L1	2686	Q8NFC6
IKGLGLPGCIPGLLP	ASF1B	181	Q9NVP2
PSGAAVPCKVEPGLG	FLNA	1011	P21333
KILCPGGEGFRPNPI	FBN1	1586	P35555
GSVLSPPPGLGRCLK	POLQ	36	O75417
LGLLCVQLGPGPKGE	IFRD2	206	Q12894
VGPKVLGPFCGEKAP	MASP1	251	P48740
LERCALPPLDPGGLK	PRDM13	431	Q9H4Q3
VAEILPAPGKLLGPC	SAT2	56	Q96F10
PAGCPGRLPELKGNI	KIFC2	396	Q96AC6
PLPVIIVGNGPSGIC	OSGIN1	16	Q9UJX0
PTCPGLGTKDALGLP	NUTM2F	601	A1L443
PTCPGLGTKDALGLP	NUTM2G	586	Q5VZR2
IEEKIEGPLCPVGPG	KHSRP	491	Q92945
LGLVVPCPERGKGPS	RAB11FIP1	1001	Q6WKZ4
PPGAIPKEACGGAPL	TACC3	251	Q9Y6A5
GIKFIPGPPGNKDLC	SMCHD1	1221	A6NHR9
PPKVLFLLGADGGCI	NDUFS1	541	P28331
KPLRAAGLPGPCAAL	PRSS47P	341	A8MTI9
PLGGDPLGDVCKPVP	SPATA31E1	156	Q6ZUB1
VPKGALLLGPPGCGK	SPG7	341	Q9UQ90
LPAPGDDVLVLLCGP	CYB5R1	266	Q9UHQ9
PLLPVTCGGVKGILH	SP140L	301	Q9H930
LPCASGGIFVLKLPP	NUP160	231	Q12769
PLGSGPGVVLYLCPE	ZXDB	261	P98169
CGSGGRKVLTPLPDP	ZNF341	756	Q9BYN7
APPELGIKCVLVGDG	RHOV	26	Q96L33
PLLAIGPAICLPGIA	TMEM215	41	Q68D42
PPGLVHLGICKPLVE	PATJ	761	Q8NI35
GLGGPLVPDLEKPSL	STAMBP	191	O95630
KPGAGGPLALDIPAL	MYO18B	1226	Q8IUG5
PKRANICPHLPGGGL	nan	6	Q5W150
APALAAVPGGKPILC	TRAP1	21	Q12931
PEPEGGLKCLIPEGA	TNK1	101	Q13470
RVGIIPPKGCLLYGP	PSMC6	161	P62333
PGQPIGSCSPLGLKL	TARBP1	436	Q13395
TILALAGEGGKPCPP	THSD7B	631	Q9C0I4
GAVPKGAPLLVCGSP	TYSND1	211	Q2T9J0
GVPPLIGGAVLCFIP	SLC16A10	456	Q8TF71