Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	4.56e-05	12	113	3	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	4.56e-05	12	113	3	IPR027970
Domain	Interferon	IFNA5 IFNA17 IFNA21	1.38e-04	17	113	3	PF00143
Domain	INTERFERON_A_B_D	IFNA5 IFNA17 IFNA21	1.38e-04	17	113	3	PS00252
Domain	Interferon_alpha/beta/delta	IFNA5 IFNA17 IFNA21	1.38e-04	17	113	3	IPR000471
Domain	IFabd	IFNA5 IFNA17 IFNA21	1.38e-04	17	113	3	SM00076
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_TAT_TO_TLR2_4_NFKB_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	1.01e-04	17	77	3	M47564
Pathway	KEGG_MEDICUS_REFERENCE_CGAS_STING_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	1.21e-04	18	77	3	M47539
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF7_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	1.43e-04	19	77	3	M47450
Pathway	KEGG_MEDICUS_REFERENCE_TLR7_9_IRF7_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	1.67e-04	20	77	3	M47617
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_II_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	1.94e-04	21	77	3	M47909
Pathway	KEGG_MEDICUS_REFERENCE_TLR7_8_9_IRF5_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.24e-04	22	77	3	M47897
Pathway	KEGG_MEDICUS_REFERENCE_RIG_I_NFKB_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.24e-04	22	77	3	M47616
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_IFN_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.57e-04	23	77	3	M47452
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	IFNA5 IFNA17 IFNA21	2.57e-04	23	77	3	MM15634
Pathway	KEGG_MEDICUS_REFERENCE_RIG_I_IRF7_3_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.92e-04	24	77	3	M47576
Pathway	KEGG_MEDICUS_REFERENCE_MDA5_IRF7_3_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.92e-04	24	77	3	M47782
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	2.92e-04	24	77	3	M47908
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	IFNA5 IFNA17 IFNA21	3.72e-04	26	77	3	M982
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION	IFNA5 IFNA17 IFNA21	5.72e-04	30	77	3	M936
Pathway	WP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY	IFNA5 IFNA17 IFNA21	6.31e-04	31	77	3	M39897
Pathway	KEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY	IFNA5 IFNA17 IFNA21	6.31e-04	31	77	3	M47964
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	IFNA5 IFNA17 IFNA21	8.30e-04	34	77	3	MM15631
Pathway	REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES	IFNA5 IFNA17 IFNA21	9.04e-04	35	77	3	M48246
Pathway	KEGG_REGULATION_OF_AUTOPHAGY	IFNA5 IFNA17 IFNA21	9.04e-04	35	77	3	M6382
Pathway	KEGG_MEDICUS_REFERENCE_HEME_BIOSYNTHESIS	HMBS ALAS2	1.03e-03	9	77	2	M47606
Pathway	WP_HEME_BIOSYNTHESIS	HMBS ALAS2	1.03e-03	9	77	2	M39470
Pathway	WP_HEMESYNTHESIS_DEFECTS_AND_PORPHYRIAS	HMBS ALAS2	1.03e-03	9	77	2	M45555
Pathway	WP_HEME_BIOSYNTHESIS	HMBS ALAS2	1.03e-03	9	77	2	MM15895
Pathway	WP_INTERFERONMEDIATED_SIGNALING	IFNA5 IFNA17 IFNA21	1.07e-03	37	77	3	M39785
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	NCAPD3 GAK AUP1 COQ5 ELP1 FASTKD2 SLC25A22 MSH6 AHR RAB39A ANKRD52	6.19e-06	606	116	11	36538041
Pubmed	Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	16565497
Pubmed	The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoter.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	11846978
Pubmed	Identification of distal silencing elements in the murine interferon-A11 gene promoter.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	8760352
Pubmed	Evolution of the interferon alpha gene family in eutherian mammals.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	17512142
Pubmed	Repression of the murine interferon alpha 11 gene: identification of negatively acting sequences.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	1886773
Pubmed	Role of interferons in the regulation of cell proliferation, differentiation, and development.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	7530016
Pubmed	Nonviral interferon alpha gene therapy inhibits growth of established tumors by eliciting a systemic immune response.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	9794206
Pubmed	Multiple pathways of interferon-induced gene expression in murine macrophages.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	7684767
Pubmed	Characterization of murine interferon-alpha 12 (MuIFN-alpha12): biological activities and gene expression.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	17451966
Pubmed	Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	16611902
Pubmed	Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	22912583
Pubmed	Structure and expression of a new murine interferon-alpha gene: MuIFN-alpha I9.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	3758677
Pubmed	Mapping the genetic region coding for herpes simplex virus resistance to mouse interferon alpha/beta.	IFNA5 IFNA17 IFNA21	7.78e-06	12	116	3	8245849
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	AUP1 DLL4 ZNF217 PREX2 MSH6 KMT2C SINHCAF PBRM1 TRIB3 CLPB BTBD7 ZNF408 AHR TMEM68 HECTD1 ZNF574	8.85e-06	1327	116	16	32694731
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 NCAPD3 ABCA4 AUP1 ELP1 ZNF251 SINHCAF PBRM1 MCRS1 ANKRD52 KDM6A	1.00e-05	638	116	11	31182584
Pubmed	Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	12930842
Pubmed	Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	2014240
Pubmed	An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	18005734
Pubmed	Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	12050368
Pubmed	Organization, structure and expression of murine interferon alpha genes.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	2987810
Pubmed	Isolation and bacterial expression of a murine alpha leukocyte interferon gene.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	6094686
Pubmed	Anti-retroviral effects of type I IFN subtypes in vivo.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	19130550
Pubmed	Isolation and characterization of a novel interferon-alpha-encoding gene, IFN-alpha 11, within a murine IFN cluster.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	1655578
Pubmed	Isolation and characterization of a functional murine interferon alpha gene which is not expressed in fibroblasts upon virus induction.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	2471809
Pubmed	HIV-1 Gag-virus-like particles inhibit HIV-1 replication in dendritic cells and T cells through IFN-α-dependent upregulation of APOBEC3G and 3F.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	22739040
Pubmed	Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	8438572
Pubmed	Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	9343822
Pubmed	Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	9181467
Pubmed	Evidence for a different susceptibility of primate lentiviruses to type I interferons.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	23255800
Pubmed	Distinction of mouse interferon-alpha subtypes by polymerase chain reaction utilizing consensus primers and type-specific oligonucleotide probes.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	7523540
Pubmed	Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	7510216
Pubmed	Sequencing and bacterial expression of a novel murine alpha interferon gene.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	18726328
Pubmed	Partial inhibition of human immunodeficiency virus replication by type I interferons: impact of cell-to-cell viral transfer.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	19706714
Pubmed	Distinct signature type I interferon responses are determined by the infecting virus and the target cell.	IFNA5 IFNA17 IFNA21	1.01e-05	13	116	3	18572754
Pubmed	Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.	PKM AHR	1.10e-05	2	116	2	26405201
Pubmed	Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.	TSR1 BYSL	1.10e-05	2	116	2	20805244
Pubmed	Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	14983024
Pubmed	Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	8668211
Pubmed	Interferon induction by HIV glycoprotein 120: role of the V3 loop.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	7526537
Pubmed	Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	19559726
Pubmed	HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	25972534
Pubmed	Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	15240719
Pubmed	Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	7583919
Pubmed	Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	16418394
Pubmed	APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	18272764
Pubmed	Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	2987811
Pubmed	Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	11884139
Pubmed	Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	19004943
Pubmed	Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	21172865
Pubmed	Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	2552026
Pubmed	Characterization of the murine alpha interferon gene family.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	15254193
Pubmed	Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	7532202
Pubmed	HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	16278001
Pubmed	HIV/AIDS: virus kept on a leash.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	18200012
Pubmed	Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	18200009
Pubmed	A structural basis for interferon-alpha-receptor interactions.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	17517919
Pubmed	Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	1381203
Pubmed	Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication.	IFNA5 IFNA17 IFNA21	1.28e-05	14	116	3	8345204
Pubmed	Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis?	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	17180012
Pubmed	Role of the Akt pathway in mRNA translation of interferon-stimulated genes.	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	18339807
Pubmed	Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha.	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	8786318
Pubmed	Diversity and relatedness among the type I interferons.	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	15684736
Pubmed	Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids.	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	8661419
Pubmed	Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.	IFNA5 IFNA17 IFNA21	1.60e-05	15	116	3	9520456
Pubmed	Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.	IFNA5 IFNA17 IFNA21	1.96e-05	16	116	3	22315404
Pubmed	Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity.	IFNA5 IFNA17 IFNA21	1.96e-05	16	116	3	18414664
Pubmed	Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120.	IFNA5 IFNA17 IFNA21	1.96e-05	16	116	3	7904170
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 FLNC ZNF865 KCNH3 ORC1 SLC25A22 KMT2C ARHGEF40 TRIB3 MTMR14 BTBD7 ZNF408 AP1G2 HECTD1	1.96e-05	1105	116	14	35748872
Pubmed	Characterization of the type I interferon locus and identification of novel genes.	IFNA5 IFNA17 IFNA21	2.38e-05	17	116	3	15233997
Pubmed	Inhibitory effects of human immunodeficiency virus gp120 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cells.	IFNA5 IFNA17 IFNA21	2.38e-05	17	116	3	22814248
Pubmed	Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.	IFNA5 IFNA17 IFNA21	2.84e-05	18	116	3	1905933
Pubmed	Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics.	IFNA5 IFNA17 IFNA21	2.84e-05	18	116	3	20096141
Pubmed	Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.	PKM AHR	3.30e-05	3	116	2	29752288
Pubmed	Investigation of genotype-phenotype relationship in Turkish patients with inherited retinal disease by next generation sequencing.	ABCA4 EYS	3.30e-05	3	116	2	34315337
Pubmed	Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines.	IFNA5 IFNA17 IFNA21	3.37e-05	19	116	3	7511078
Pubmed	Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages.	IFNA5 IFNA17 IFNA21	3.37e-05	19	116	3	7815507
Pubmed	Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.	IFNA5 IFNA17 IFNA21	3.37e-05	19	116	3	1385305
Pubmed	HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.	IFNA5 IFNA17 IFNA21	3.37e-05	19	116	3	17360657
Pubmed	Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.	IFNA5 IFNA17 IFNA21	3.37e-05	19	116	3	1708818
Pubmed	TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.	IFNA5 IFNA17 IFNA21	3.95e-05	20	116	3	11694501
Pubmed	Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production.	IFNA5 IFNA17 IFNA21	3.95e-05	20	116	3	8764000
Pubmed	Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect.	IFNA5 IFNA17 IFNA21	4.60e-05	21	116	3	9108403
Pubmed	HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells.	IFNA5 IFNA17 IFNA21	5.32e-05	22	116	3	7913356
Pubmed	HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.	IFNA5 IFNA17 IFNA21	5.32e-05	22	116	3	23100517
Pubmed	Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells.	IFNA5 IFNA17 IFNA21	5.32e-05	22	116	3	16160188
Pubmed	Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.	IFNA5 IFNA17 IFNA21	5.32e-05	22	116	3	20574843
Pubmed	Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation.	IFNA5 IFNA17 IFNA21	6.10e-05	23	116	3	9225992
Pubmed	Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation.	PKM IL17RA	6.59e-05	4	116	2	36577385
Pubmed	Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.	PBRM1 KDM6A	6.59e-05	4	116	2	23644518
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	USP9Y KDM6A	6.59e-05	4	116	2	10767340
Pubmed	PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.	IFNA5 IFNA17 IFNA21	6.95e-05	24	116	3	35037428
Pubmed	LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner.	IFNA5 IFNA17 IFNA21	7.88e-05	25	116	3	27183626
Pubmed	Modulation of HIV-1 transcription by cytokines and chemokines.	IFNA5 IFNA17 IFNA21	7.88e-05	25	116	3	16375755
Pubmed	Role of HIV-1 Vpu protein for virus spread and pathogenesis.	IFNA5 IFNA17 IFNA21	7.88e-05	25	116	3	18672082
Pubmed	The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.	IFNA5 IFNA17 IFNA21	8.89e-05	26	116	3	38744293
Pubmed	Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.	IFNA5 IFNA17 IFNA21	8.89e-05	26	116	3	9658081
Pubmed	Decoding type I and III interferon signalling during viral infection.	IFNA5 IFNA17 IFNA21	9.97e-05	27	116	3	30936491
Pubmed	Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.	IFNA5 IFNA17 IFNA21	9.97e-05	27	116	3	33165593
Pubmed	Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN.	IFNA5 IFNA17 IFNA21	1.11e-04	28	116	3	17277142
Cytoband	9q21.32	SPATA31D4 SPATA31D1 SPATA31D3 FRMD3	1.51e-07	19	117	4	9q21.32
Cytoband	9p22	IFNA5 IFNA17 IFNA21	3.56e-05	25	117	3	9p22
Cytoband	17p13.3	WDR81 OR1D4 TSR1 OR1D5	7.92e-05	88	117	4	17p13.3
Cytoband	7q36.1	ZNF783 KMT2C GALNT11	9.17e-04	74	117	3	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	SPATA31D4 SPATA31D1 SPATA31D3 FRMD3	1.73e-03	199	117	4	chr9q21
GeneFamily	Interferons	IFNA5 IFNA17 IFNA21	3.37e-04	32	77	3	598
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF217 SLC25A22 ANLN AP1G2 IQCM CFAP46	3.46e-06	155	117	6	8b524c65fa5c901f70c7caae4ec7fd2859eaf227
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF217 SLC25A22 ANLN AP1G2 IQCM CFAP46	3.46e-06	155	117	6	7fe8b8c0c8a9e3190cfd52d3934509e6780e1717
ToppCell	10x5'-blood\|World / Manually curated celltypes from each tissue	VCAN PKM ALAS2 IL17RA FRMD3 RASGRP2	1.21e-05	193	117	6	359d4242a7e5e51a3eaf6fe51bc1c653a402b054
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 CYP2S1 ARHGEF40 VCAN AHR IL17RA	1.40e-05	198	117	6	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 KMT2C ARHGEF40 VCAN AHR IL17RA	1.40e-05	198	117	6	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
Disease	Colorectal Carcinoma	SHANK1 FLNC ABCA4 ZNF217 PREX2 MSH6 KMT2C FCN2 MCRS1 C12orf76 DNAH8 KDM6A	1.04e-05	702	108	12	C0009402
Disease	Familial Exudative Vitreoretinopathy	ABCA4 ZNF408	1.32e-04	5	108	2	C0339539
Disease	adenoid cystic carcinoma (is_implicated_in)	KMT2C KDM6A	1.32e-04	5	108	2	DOID:0080202 (is_implicated_in)
Disease	Klatskin's tumor (is_implicated_in)	PREX2 KMT2C	1.32e-04	5	108	2	DOID:4927 (is_implicated_in)
Disease	bilirubin metabolic disorder (biomarker_via_orthology)	HMBS ALAS2	2.75e-04	7	108	2	DOID:2741 (biomarker_via_orthology)
Disease	Retinitis Pigmentosa	ABCA4 EYS ZNF408 AHR	5.89e-04	104	108	4	C0035334
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	DMXL2 TMEM132E	1.01e-03	13	108	2	C1846647
Disease	Disorder of eye	B3GLCT ABCA4 FREM1 EYS VCAN	1.12e-03	212	108	5	C0015397
Disease	BMI-adjusted adiponectin measurement	ST6GAL1 PBRM1	1.35e-03	15	108	2	EFO_0007737
Disease	obsolete aging, cognition	ENC1 AHR	1.35e-03	15	108	2	EFO_0003925, GO_0007568
Disease	Nonorganic psychosis	SHANK1 CRHR1 PBRM1	2.10e-03	69	108	3	C0349204
Disease	Non-alcoholic Fatty Liver Disease	ADH1A TRIB3 AHR	2.18e-03	70	108	3	C0400966
Disease	Nonalcoholic Steatohepatitis	ADH1A TRIB3 AHR	2.18e-03	70	108	3	C3241937
Disease	triacylglycerol 58:9 measurement	FASTKD2 TMEM132E	2.92e-03	22	108	2	EFO_0010443
Disease	Intrahepatic Cholangiocarcinoma	KMT2C PBRM1	3.48e-03	24	108	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	KMT2C PBRM1	3.48e-03	24	108	2	C3805278

Protein segments in the cluster

Peptide	Gene	Start	Entry
IFRTKHKLDFTPIGC	AHR	286	P35869
EGARKHLVCSFRLYP	DCANP1	126	Q8TF63
QLLHRDPFTVICGRK	ARHGEF40	1271	Q8TER5
RGHCGKTFAILERFL	B3GLCT	321	Q6Y288
KDGFIQRHLPTIRCL	VCAN	3326	P13611
KLLIVFPHFCLGRGL	ABCA4	1831	P78363
FTCRRKPIHHFLGIS	ADH1A	131	P07327
CRLNEFLLPKISHRG	FAM47DP	71	A6NHR8
ELCERSPAALRHFRK	AP1G2	201	O75843
KAPITQFLGRAHLCR	CFAP46	76	Q8IYW2
CPDLLRKFAEVGFIH	CFAP46	646	Q8IYW2
EPGCRTFFRVCLKHF	DLL4	51	Q9NR61
CLFRRIVACHFIKPR	B3GALT5	276	Q9Y2C3
FSCKRLHPDPFLRSL	DMXL2	1786	Q8TDJ6
CRFLHDVGRYLETKP	DUS3L	141	Q96G46
FVLCRDFKGRTPIHL	ANKRD52	746	Q8NB46
RIAHRIKGFRCLPFI	BCKDK	101	O14874
CRYPVLRIEAHKRGS	CBLL2	96	Q8N7E2
QPFRIVFLLVGHKCD	RAB39A	116	Q14964
ISFKEPHIFSRRERC	IQCM	106	A0A1B0GVH7
EVRCSLSRGVPFKIH	PCDHGB7	381	Q9Y5F8
RKSPFILLHCGALRA	KCNH3	211	Q9ULD8
FVFLILRLPFCGHNI	OR52E4	161	Q8NGH9
RLRCDHGKPVGDLFT	IL17RA	466	Q96F46
GDCVFIKSHGLVRPR	PBRM1	1161	Q86U86
HLLRCLKNPLGTFIF	PRAMEF17	286	Q5VTA0
LKPRLRAVHGGFEDC	KMT2C	4331	Q8NEZ4
RGKSCLFRLQPATLH	MAP10	91	Q9P2G4
CGKQFLHLFLVEGRP	EYS	2196	Q5T1H1
CVGFRFPILGVHLKD	RASGRP2	296	Q7LDG7
RGRFVCPVILFKGKH	MTMR14	126	Q8NCE2
LLDFLCIRKHFLGRR	DIO3	61	P55073
KPFLERFGERCQEHS	ANLN	371	Q9NQW6
PKSVIICQHGIDRRF	KIAA1109	956	Q2LD37
RISPFSCLKDRHDFG	IFNA21	46	P01568
PSFCRAKEIHLRLGL	KDM6A	161	O15550
HEKPLVFLERFRTGL	CCDC97	101	Q96F63
KHEAFLPFSLGKRVC	CYP2S1	426	Q96SQ9
LHVVLCFSPVGEKFR	DNAH8	2946	Q96JB1
GKLFIIPCSRVGHIF	GALNT11	366	Q8NCW6
RISPFSCLKDRHDFG	IFNA5	46	P01569
CLLKRLPNRHIGISF	FLNC	1991	Q14315
RVGKLTPQVFDCHFL	FREM1	71	Q5H8C1
CARKILRHEGPSAFL	SLC25A22	271	Q9H936
RQAHLYRGIFPVLCK	PKM	461	P14618
SGFKVCLRTPHLEKR	ELP1	471	O95163
LLCILTKPHAGFRIA	MICU3	226	Q86XE3
FLGEVHCGTNVRRKP	PADI2	641	Q9Y2J8
RVDTCHTPFGKRLLK	MSH6	761	P52701
VKTHQFLFGIGRCPI	ALAS2	26	P22557
ISHPGRLCLLIFSIF	OR2T10	21	Q8NGZ9
RFCEVPACKRHLLGR	ORC1	91	Q13415
CEHLFLKLVGRFAPE	ITPRIPL1	401	Q6GPH6
VPFSLFGKSFIRRCH	CPT1C	546	Q8TCG5
IFLPLLRGHSLFTCE	FZD6	11	O60353
LCFRQHPFEDGAKLR	GAK	256	O14976
QIKRDIFHGRLLCSF	FRMD3	131	A2A2Y4
LCLFHGNALERRKFG	DNAH1	3821	Q9P2D7
PVHLFRLSGKCFSLV	GNPTG	61	Q9UJJ9
CFGRPQVAKTLLRHG	HECTD1	436	Q9ULT8
GPRTCKDLLDRGHFL	FCN2	101	Q15485
FKQFRLLPGTREHAL	CCDC73	601	Q6ZRK6
VAFVLFLRLRPGCTH	CRHR1	136	P34998
HRAILAARCPFFKTL	BTBD7	156	Q9P203
VHLGVKFSCRFTLRE	MCRS1	156	Q96EZ8
LFPGCVHLRKVKFQA	MAPRE3	51	Q9UPY8
CFGALFLLPHSSRLK	MAN1C1	36	Q9NR34
EAHRVLKPGGRFLCL	COQ5	231	Q5HYK3
RPILKAHFRRDEFLG	CLPB	546	Q9H078
LCARPRKTGHALFLL	ENC1	286	O14682
RKFPHLEFRSIRGNL	HMBS	156	P08397
FHFPRRSQKDCLLGL	PKD1L1	2691	Q8TDX9
VFHFLGFRTEKRELP	BYSL	361	Q13895
RISPFSCLKDRHDFG	IFNA17	46	P01571
EGYRSLPRHQLLCFK	OSGIN1	356	Q9UJX0
GRVTCFTDHEIPFRL	PCDH11Y	426	Q9BZA8
FLLTRVTFCGPREIH	OR1D4	161	P47884
FLLTRVTFCGPREIH	OR1D5	161	P58170
LLVKLFNGCPLRIHS	MAP4K1	486	Q92918
GEHAFFRLALPRIRK	GRIN3B	851	O60391
CFKGELPLRAVHINL	PLEKHN1	261	Q494U1
FGVTERLPCVRLHAF	TMEM132E	156	Q6IEE7
PRGLRSFKTIFAEHL	RPL3L	96	Q92901
EPCKNVHVLRTGFRI	FASTKD2	281	Q9NYY8
DLRHPKRILFGTDYC	PRAMEF25	446	A6NGN4
PGIKFSAEALRCHLR	ST6GAL1	131	P15907
KFLCDPRSGHTLLAF	TANC2	781	Q9HCD6
SPLFLIRVCGVCFHR	SPATA31D4	591	Q6ZUB0
RIACRGKLAHVSFPL	PRR32	201	B1ATL7
CETRAGKHVPRALFV	TUBAL3	61	A6NHL2
RIGIPDLHQTKCLRF	SHANK1	76	Q9Y566
GEFCLAHLLLKRNPV	NCAPD3	1036	P42695
CKGERNFAERHILPA	C12orf76	66	Q8N812
RLFDSHRLPGDCFLL	AUP1	11	Q9Y679
RFGEVLIDTHLFKPC	SINHCAF	181	Q9NP50
SPLFLIRVCGVCFHR	SPATA31D3	591	P0C874
CGKFFRQISGLIEHR	ZNF671	346	Q8TAW3
PVCGKRFRESFHLSK	ZNF865	581	P0CJ78
KEELIFHCGFRRFRA	TSR1	611	Q2NL82
TCRVVADHFVFKIPG	TMEM68	151	Q96MH6
FGQAFSKILHCLARP	TTI2	26	Q6NXR4
HGLVLRDLKLCRFVF	TRIB3	176	Q96RU7
LFLIRICGVCFHRPQ	SPATA31D1	596	Q6ZQQ2
HREGVFKCPLCSRVF	ZNF574	331	Q6ZN55
QCGKAFARRPSLRLH	ZNF408	441	Q9H9D4
CSQKGRPFHLFRLLI	TBC1D23	161	Q9NUY8
KGVRLYCRLHSLFTP	PREX2	481	Q70Z35
GLDPQALRHLKVVCF	SLC9B1	171	Q4ZJI4
AFRGKHLSLIVRFPN	USP9Y	881	O00507
QFGHVRRCILPFDKE	SLIRP	41	Q9GZT3
RRCILPFDKETGFHR	SLIRP	46	Q9GZT3
FTLRLHCGPARNAKL	nan	146	Q0VFX4
VRIHTGEKRFVCPFQ	ZFP42	266	Q96MM3
RLHRRIHTGEKPFGC	ZNF251	281	Q9BRH9
CGFLFPNKESLIEHR	ZNF217	221	O75362
LRKRGLVSHACYPLF	TINAG	296	Q9UJW2
KPLFRHFRRIDSCLQ	RAPGEFL1	291	Q9UHV5
FVDCRKPGLQHEFRL	WDR81	1766	Q562E7
RGELPSVRSKFHVLF	ZDHHC15	201	Q96MV8
VQPCLRKAHGEFIFL	VWA5B1	351	Q5TIE3
CGKAFRRPSDLFRHQ	ZNF783	471	Q6ZMS7