Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.28e-1234858GO:0008395
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

6.29e-1024856GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.37e-0927856GO:0008391
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

1.46e-0949857GO:0016712
GeneOntologyMolecularFunctionaromatase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

7.31e-0935856GO:0070330
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

3.15e-08115858GO:0004497
GeneOntologyMolecularFunctioniron ion binding

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 RRM2

3.66e-08166859GO:0005506
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

7.44e-083853GO:0008389
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 KDM4E

1.40e-07194859GO:0016705
GeneOntologyMolecularFunctionheme binding

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

3.04e-07154858GO:0020037
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP2C19 CYP2C8 CYP2C9 RRM2

4.03e-0715854GO:0016725
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

4.91e-07164858GO:0046906
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP2C19 CYP2C8 CYP2C9

4.11e-068853GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP2C19 CYP2C8 CYP2C9

4.11e-068853GO:0034875
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

1.20e-0511853GO:0101020
GeneOntologyMolecularFunction(R)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

1.79e-052852GO:0052741
GeneOntologyMolecularFunctionlimonene monooxygenase activity

CYP2C19 CYP2C9

1.79e-052852GO:0019113
GeneOntologyMolecularFunction(S)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

1.79e-052852GO:0018675
GeneOntologyMolecularFunction(S)-limonene 7-monooxygenase activity

CYP2C19 CYP2C9

1.79e-052852GO:0018676
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

2.62e-0514853GO:0008401
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2

5.36e-053852GO:0005220
GeneOntologyMolecularFunctionlinoleic acid epoxygenase activity

CYP2C19 CYP2C9

1.07e-044852GO:0071614
GeneOntologyMolecularFunctionarachidonate 11,12-epoxygenase activity

CYP2C19 CYP2C9

1.07e-044852GO:0008405
GeneOntologyMolecularFunctionfatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

1.78e-045852GO:0120502
GeneOntologyMolecularFunctionlong-chain fatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

1.78e-045852GO:0120319
GeneOntologyMolecularFunctionarachidonate 14,15-epoxygenase activity

CYP2C19 CYP2C9

1.78e-045852GO:0008404
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

7.88e-0410852GO:0001849
GeneOntologyMolecularFunctionoxidoreductase activity

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 KDM4E RRM2

1.52e-037668510GO:0016491
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2

1.58e-0314852GO:0070679
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO3A KIF23 DNAH17 KIF17

1.62e-03118854GO:0003774
GeneOntologyMolecularFunctionprotein phosphatase binding

MAGI3 AKAP11 MVP IQGAP1 ITPR1

2.04e-03210855GO:0019903
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2

2.62e-0318852GO:0015278
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNH6 CHRNA1 ITPR1 ITPR2

3.02e-03140854GO:0099094
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF23 DNAH17 KIF17

3.32e-0370853GO:0003777
GeneOntologyMolecularFunctiontransition metal ion binding

CYP2A6 LIG3 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 ZNFX1 RRM2 USP33

4.40e-0311898512GO:0046914
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1E PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2 IQGAP1 ITPR1 ITPR2

4.54e-03749859GO:0005509
GeneOntologyMolecularFunctionATP-dependent activity

MYO3A KIF23 DNAH17 ZNFX1 SMC5 KIF17 ABCA9 ACSS3

4.60e-03614858GO:0140657
GeneOntologyMolecularFunctionopsonin binding

C4A C4B

5.04e-0325852GO:0001846
GeneOntologyMolecularFunctionphosphatase binding

MAGI3 AKAP11 MVP IQGAP1 ITPR1

5.40e-03264855GO:0019902
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

2.50e-1022836GO:0019373
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

1.05e-0868837GO:0019369
GeneOntologyBiologicalProcessxenobiotic metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP2U1

1.00e-07141838GO:0006805
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP2C19 CYP2C8 CYP2C9 CYP2U1

2.37e-0714834GO:0097267
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

6.80e-07124837GO:0001676
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

8.44e-07128837GO:0033559
GeneOntologyBiologicalProcessicosanoid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

1.70e-06142837GO:0006690
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP2U1

3.13e-06222838GO:0071466
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

7.39e-0610833GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

7.39e-0610833GO:0009804
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

8.15e-06180837GO:0120254
GeneOntologyBiologicalProcessxenobiotic catabolic process

CYP2A6 CYP2C19 CYP2C8 CYP2C9

1.45e-0537834GO:0042178
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 PRKAG1 CYP2U1 AKT2 MCCC1

3.46e-057318312GO:0032787
GeneOntologyBiologicalProcessfatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 PRKAG1 CYP2U1 AKT2

9.79e-05461839GO:0006631
GeneOntologyBiologicalProcessmonoterpenoid metabolic process

CYP2C19 CYP2C9

2.37e-046832GO:0016098
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 PRKAG1 CYP2U1 AKT2 MCCC1

2.39e-0410358313GO:0019752
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP2U1

2.59e-04525839GO:0009410
GeneOntologyBiologicalProcessoxoacid metabolic process

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 PRKAG1 CYP2U1 AKT2 MCCC1

2.96e-0410588313GO:0043436
GeneOntologyBiologicalProcessorganic acid metabolic process

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 PRKAG1 CYP2U1 AKT2 MCCC1

3.12e-0410648313GO:0006082
GeneOntologyBiologicalProcessmitotic sister chromatid cohesion

PDS5B PDS5A SMC5

4.08e-0436833GO:0007064
GeneOntologyBiologicalProcesspositive regulation of apoptotic cell clearance

C4A C4B

4.41e-048832GO:2000427
GeneOntologyCellularComponentmicrotubule

CYP2A6 CYP2A7 CYP2A13 DCDC2 KIF23 DNAH17 EML6 SPAG17 KIF17 RCC2 IQGAP1

1.30e-055338711GO:0005874
GeneOntologyCellularComponentaxoneme

CFAP100 SPTBN5 DCDC2 DNAH17 LCA5L SPAG17 KIF17

2.52e-05207877GO:0005930
GeneOntologyCellularComponentciliary plasm

CFAP100 SPTBN5 DCDC2 DNAH17 LCA5L SPAG17 KIF17

2.60e-05208877GO:0097014
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

CYP2A6 CYP2A7 MYO3A CYP2A13 DCDC2 KIF23 DNAH17 EML6 EVPL SPAG17 KIF17 RCC2 IQGAP1

8.47e-058998713GO:0099513
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

CFAP100 SPTBN5 DCDC2 DNAH17 LCA5L SPAG17 KIF17

3.57e-04317877GO:0032838
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

4.72e-048872GO:0106139
GeneOntologyCellularComponentsarcoplasmic reticulum

AGL AKT2 ITPR1 ITPR2

5.00e-0488874GO:0016529
GeneOntologyCellularComponentother organism part

C4A C4B

6.05e-049872GO:0044217
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2

6.05e-049872GO:0031095
GeneOntologyCellularComponentcytoplasmic region

CFAP100 SPTBN5 DCDC2 DNAH17 LCA5L SPAG17 KIF17

7.61e-04360877GO:0099568
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2

9.19e-0411872GO:0031094
GeneOntologyCellularComponentchromosome, centromeric region

PDS5B SMARCC2 PDS5A KDM4E SMC5 RCC2

1.04e-03276876GO:0000775
GeneOntologyCellularComponentsupramolecular fiber

CYP2A6 CYP2A7 MYO3A CYP2A13 DCDC2 KIF23 DNAH17 EML6 EVPL SPAG17 KIF17 RCC2 IQGAP1

1.14e-0311798713GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

CYP2A6 CYP2A7 MYO3A CYP2A13 DCDC2 KIF23 DNAH17 EML6 EVPL SPAG17 KIF17 RCC2 IQGAP1

1.21e-0311878713GO:0099081
GeneOntologyCellularComponentsarcoplasm

AGL AKT2 ITPR1 ITPR2

1.32e-03114874GO:0016528
MousePhenodecreased intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13 CYP27A1

1.23e-0617694MP:0002647
MousePhenoabnormal intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13 CYP27A1

1.99e-0619694MP:0002645
MousePhenoabnormal intestinal lipid absorption

CYP2A6 CYP2A7 CYP2A13 CYP27A1

1.55e-0531694MP:0005342
MousePhenoabnormal bile salt homeostasis

CYP2A6 CYP2A7 CYP2A13 CYP27A1

8.26e-0547694MP:0005365
MousePhenocarpoptosis

MAPK6 CHRNA1

1.43e-044692MP:0005162
MousePhenoabnormal intestinal absorption

CYP2A6 CYP2A7 CYP2A13 CYP27A1

2.02e-0459694MP:0001666
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.47e-1145858IPR002401
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

9.86e-1153858IPR017972
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.81e-1057858PS00086
Domain-

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.09e-10588581.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.09e-1058858PF00067
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.77e-1060858IPR001128
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

3.63e-074853IPR008067
DomainCadherin_tail

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

6.74e-0737855PF15974
DomainCadherin_CBD

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

6.74e-0737855IPR031904
DomainCadherin_2

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.16e-0565855PF08266
DomainCadherin_N

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.16e-0565855IPR013164
DomainCadherin

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2 FREM3

1.63e-05118856IPR002126
DomainInsP3_rcpt-bd

ITPR1 ITPR2

6.12e-053852IPR000493
DomainCadherin_CS

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.40e-04109855IPR020894
DomainCADHERIN_1

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.66e-04113855PS00232
DomainCadherin

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.66e-04113855PF00028
DomainCADHERIN_2

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.72e-04114855PS50268
Domain-

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.72e-041148552.60.40.60
DomainCA

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.80e-04115855SM00112
DomainCadherin-like

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.87e-04116855IPR015919
DomainAnaphylatoxin_comp_syst

C4A C4B

2.03e-045852IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

2.03e-045852IPR001840
DomainRIH_assoc

ITPR1 ITPR2

3.03e-046852PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2

3.03e-046852IPR013662
DomainRIH_dom

ITPR1 ITPR2

3.03e-046852IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2

3.03e-046852IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2

3.03e-046852IPR015925
Domain-

ITPR1 ITPR2

3.03e-0468521.25.10.30
DomainRYDR_ITPR

ITPR1 ITPR2

3.03e-046852PF01365
DomainIns145_P3_rec

ITPR1 ITPR2

3.03e-046852PF08709
DomainSpectrin/alpha-actinin

SPTBN5 MCF2L2 EVPL

4.10e-0432853IPR018159
DomainSPEC

SPTBN5 MCF2L2 EVPL

4.10e-0432853SM00150
DomainANATO

C4A C4B

4.24e-047852SM00104
DomainANATO

C4A C4B

4.24e-047852PF01821
DomainANAPHYLATOXIN_2

C4A C4B

4.24e-047852PS01178
DomainANAPHYLATOXIN_1

C4A C4B

4.24e-047852PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

4.24e-047852IPR000020
DomainThiol-ester_cl

C4A C4B

5.63e-048852PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

5.63e-048852IPR019565
DomainMacrogloblnA2_CS

C4A C4B

5.63e-048852IPR019742
DomainA2M_N

C4A C4B

9.00e-0410852PF01835
DomainMIR

ITPR1 ITPR2

9.00e-0410852PS50919
DomainMIR

ITPR1 ITPR2

9.00e-0410852PF02815
DomainMIR

ITPR1 ITPR2

9.00e-0410852SM00472
DomainA2M_N

C4A C4B

9.00e-0410852IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

9.00e-0410852IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

9.00e-0410852PS00477
DomainA2M

C4A C4B

9.00e-0410852PF00207
DomainMIR_motif

ITPR1 ITPR2

9.00e-0410852IPR016093
DomainA2M_N_2

C4A C4B

9.00e-0410852IPR011625
DomainA2M_comp

C4A C4B

9.00e-0410852IPR011626
DomainA2M_N_2

C4A C4B

9.00e-0410852PF07703
DomainA2M_recep

C4A C4B

9.00e-0410852PF07677
DomainA2M_comp

C4A C4B

9.00e-0410852PF07678
DomainMacroglobln_a2

C4A C4B

9.00e-0410852IPR001599
DomainP-loop_NTPase

MYO3A KIF23 SAMD9L TJP1 MAGI3 ZNFX1 CHST1 SMC5 KIF17 ABCA9 IQGAP1

1.57e-038488511IPR027417
DomainIon_trans_dom

KCNH6 CACNA1E ITPR1 ITPR2

1.82e-03114854IPR005821
DomainIon_trans

KCNH6 CACNA1E ITPR1 ITPR2

1.82e-03114854PF00520
DomainC345C

C4A C4B

2.66e-0317852SM00643
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

2.99e-0318852IPR008930
DomainNTR

C4A C4B

3.33e-0319852PF01759
DomainNetrin_module_non-TIMP

C4A C4B

3.33e-0319852IPR018933
DomainHEAT_REPEAT

PDS5B PDS5A EIF4G3

4.00e-0370853PS50077
DomainARM-type_fold

PDS5B PDS5A ZNFX1 EIF4G3 ITPR1 ITPR2

4.50e-03339856IPR016024
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

3.44e-1211656M27130
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

3.64e-1062658M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

4.73e-1064658M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

6.09e-1066658MM14839
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

7.20e-1023656M5372
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.25e-0925656MM14846
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8

1.38e-0912655MM14847
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1 CHST1

1.03e-081836510M39588
PathwayKEGG_RETINOL_METABOLISM

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6

1.61e-0864657M9488
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.38e-08104658M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.57e-08105658MM14842
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6

3.70e-0872657M9257
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C8 CYP2C9 CYP2U1

5.10e-089654M27143
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

6.98e-07220659M10320
PathwayWP_TAMOXIFEN_METABOLISM

CYP2A6 CYP2C19 CYP2C8 CYP2C9

2.32e-0621654M39631
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8 CYP2C9

5.15e-068653M27135
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

7.04e-06219658MM14838
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

CYP2A6 CYP2C19 CYP2C9 UGT1A6

1.18e-0531654M39476
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

CYP2A6 CYP2C19 CYP2C9 UGT1A6

1.34e-0532654M39567
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C8 CYP2U1

1.50e-0511653MM14863
PathwayWP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID

CYP2C19 CYP2C8 CYP2C9

2.00e-0512653M48064
PathwayREACTOME_MITOTIC_TELOPHASE_CYTOKINESIS

PDS5B KIF23 PDS5A

2.59e-0513653MM15363
PathwayREACTOME_MITOTIC_TELOPHASE_CYTOKINESIS

PDS5B KIF23 PDS5A

2.59e-0513653M27661
PathwayREACTOME_ASPIRIN_ADME

CYP2C19 CYP2C8 CYP2C9 UGT1A6

4.87e-0544654M45014
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A7 CYP2A13

7.27e-0518653MM14841
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP2A6 CYP2A7 CYP2A13 UGT1A6

8.74e-0551654M17726
PathwayKEGG_ARACHIDONIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9 CYP2U1

1.45e-0458654M5410
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9 CYP2U1

1.55e-0459654M27140
PathwayWP_ESTROGEN_METABOLISM_WP5276

CYP2C19 CYP2C8 CYP2C9

1.77e-0424653M46445
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

2.07e-045652M47808
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2

2.07e-045652M49000
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9 UGT1A6

3.00e-0470654M16794
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

3.10e-046652M47960
PathwayREACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS

CYP2C8 CYP2C9

3.10e-046652M27909
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9

3.14e-0429653M2920
PathwayWP_ARACHIDONATE_EPOXYGENASE_EPOXIDE_HYDROLASE

CYP2C8 CYP2C9

4.33e-047652M39515
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

4.33e-047652MM14685
PathwayKEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION

PDS5B PDS5A

4.33e-047652M47869
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8

4.33e-047652MM14856
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1E IQGAP1 ITPR1 ITPR2

4.55e-0478654M1921
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

5.76e-048652M47872
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C8 CYP2C9

5.76e-048652M27891
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

5.76e-048652M27031
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

AKT2 ITPR1 ITPR2

5.99e-0436653M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

CYP27A1 ITPR1 ITPR2

5.99e-0436653M39831
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

7.38e-049652M47852
PathwayREACTOME_COHESIN_LOADING_ONTO_CHROMATIN

PDS5B PDS5A

9.20e-0410652M27178
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

9.20e-0410652M47661
PathwayREACTOME_COHESIN_LOADING_ONTO_CHROMATIN

PDS5B PDS5A

9.20e-0410652MM14892
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

IQGAP1 ITPR1 ITPR2

9.45e-0442653M791
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

1.12e-0311652M47874
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

PDS5B PDS5A

1.12e-0311652M27177
PathwayREACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION

PDS5B PDS5A

1.12e-0311652MM14891
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

1.12e-0311652M49033
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

1.12e-0311652MM1430
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2

1.12e-0311652M27466
PathwaySIG_CHEMOTAXIS

AKT2 ITPR1 ITPR2

1.16e-0345653M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

AKT2 ITPR1 ITPR2

1.23e-0346653M8626
PathwayWP_VALPROIC_ACID_PATHWAY

CYP2A6 CYP2C9

1.34e-0312652M39371
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

1.34e-0312652MM1368
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C19 CYP2C8

1.34e-0312652MM15616
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1E IQGAP1 ITPR1 ITPR2

1.54e-03108654M17034
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

1.58e-0313652M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.58e-0313652M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.58e-0313652M47751
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B

1.58e-0313652M4732
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

1.58e-0313652MM14553
PathwayREACTOME_DRUG_ADME

CYP2C19 CYP2C8 CYP2C9 UGT1A6

1.59e-03109654M45012
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

CYP2C8 UGT1A6

1.84e-0314652M39328
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP2C19 CYP2C9

1.84e-0314652MM15842
PathwayREACTOME_FATTY_ACIDS

CYP2A7 CYP2A13

2.11e-0315652M27126
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

2.11e-0315652M7146
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

2.41e-0316652M26945
PathwayWP_DEREGULATION_OF_RAB_AND_RAB_EFFECTOR_GENES_IN_BLADDER_CANCER

TBC1D10A UNC13D

2.41e-0316652M39391
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C4A C4B

2.72e-0317652MM15944
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

2.72e-0317652MM1369
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1E ITPR1 ITPR2

2.78e-0361653MM15071
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2U1

2.78e-0361653MM14861
PathwayWP_MFAP5_EFFECT_ON_PERMEABILITY_AND_MOTILITY_OF_ENDOTHELIAL_CELLS_VIA_CYTOSKELETON_REARRANGEMENT

TJP1 ITPR1

3.05e-0318652M39808
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2

3.40e-0319652M27423
PathwayREACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS

CYP2C8 CYP2C9

3.40e-0319652M27889
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.40e-0319652M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

3.40e-0319652M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.77e-0320652M47688
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B

3.77e-0320652M917
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

8.31e-12208869890157
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.01e-117088815128046
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C9

1.16e-11988537838304
Pubmed

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

CYP2A6 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.82e-101488519290787
Pubmed

Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

2.72e-101588515640798
Pubmed

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

5.58e-101788529911975
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C9

5.58e-101788527197076
Pubmed

CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

7.72e-101888515570159
Pubmed

Genomic organization of the family of CNR cadherin genes in mice and humans.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

7.72e-101888510662547
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C9 CYP27A1

1.44e-094488612745259
Pubmed

Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.78e-092488524698270
Pubmed

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.

CYP2A6 CYP2C19 CYP2C8 CYP2C9

7.94e-091088419651758
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

8.68e-092888515347688
Pubmed

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.

PRRC2C POC1B DOCK7 EVPL C4A EIF4G3 YY1 RCC2 IQGAP1 ITPR2

1.18e-08329881034316702
Pubmed

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

CYP2A6 CYP2C19 CYP2C8 CYP2C9

1.25e-081188415039299
Pubmed

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

CYP2A6 CYP2C19 CYP2C8 CYP2C9

1.25e-081188415469410
Pubmed

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388328687336
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

1.57e-08388331645370
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838833346244
Pubmed

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24.

CYP2C19 CYP2C8 CYP2C9

1.57e-0838838530044
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838832733794
Pubmed

Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388321173785
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838838297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838838188299
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838838484736
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838838250953
Pubmed

CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388335134542
Pubmed

Genetic polymorphisms of CYP2C8, CYP2C9 and CYP2C19 in Ecuadorian Mestizo and Spaniard populations: a comparative study.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388324430292
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838832703500
Pubmed

Distribution of CYP2C polymorphisms in an Amerindian population of Brazil.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388321977947
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838831417950
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

1.57e-08388324045421
Pubmed

Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388320665013
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

1.57e-08388332987105
Pubmed

Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388327803446
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

1.57e-08388322217847
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838832765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

1.57e-0838832415518
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

1.57e-08388322890016
Pubmed

Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388319954515
Pubmed

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19.

CYP2C19 CYP2C8 CYP2C9

1.57e-08388323118231
Pubmed

The DNA sequence and comparative analysis of human chromosome 5.

ZNF131 PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.86e-087588615372022
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A7 CYP2A13 CYP2U1

5.11e-081588429968852
Pubmed

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

CYP2C19 CYP2C8 CYP2C9

6.25e-0848832009263
Pubmed

Allele frequency differences of cytochrome P450 polymorphisms in a sample of New Zealand Māori.

CYP2A6 CYP2C19 CYP2C9

6.25e-08488318425152
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

6.25e-0848839408084
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

6.25e-08488310490589
Pubmed

Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.

CYP2C19 CYP2C8 CYP2C9

6.25e-08488321798861
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13

6.25e-0848831970547
Pubmed

Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population.

CYP2C19 CYP2C8 CYP2C9

6.25e-08488316025294
Pubmed

Biochemistry and molecular biology of the human CYP2C subfamily.

CYP2C19 CYP2C8 CYP2C9

6.25e-0848837704034
Pubmed

Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.

CYP2C19 CYP2C9 UGT1A6

6.25e-08488336718958
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

6.25e-0848837565685
Pubmed

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.

CYP2C19 CYP2C8 CYP2C9

6.25e-08488328990182
Pubmed

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

CYP2C19 CYP2C8 CYP2C9

6.25e-08488323755828
Pubmed

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

CYP2C19 CYP2C8 CYP2C9

6.25e-08488319706858
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PDS5B KIF23 TJP1 PRRC2C DOCK7 SMARCC2 PDS5A EIF4G3 MVP CNOT1 RCC2 IQGAP1

9.72e-08653881222586326
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PDS5B CACNA1E CYP2A6 CYP2A13 TJP1 PRRC2C EML6 ZSCAN26 DKC1 SMARCC2 MAGI3 MAPK6 EIF4G3 SPAG17 YY1 CHRNA1 IQGAP1

1.08e-071442881735575683
Pubmed

Prevalence of CYP450 gene variations in patients with type 2 diabetes.

CYP2C19 CYP2C8 CYP2C9

1.56e-07588320857895
Pubmed

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

CYP2C19 CYP2C8 CYP2C9

1.56e-07588319415824
Pubmed

No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.

CYP2C8 CYP2C9 UGT1A6

1.56e-07588316141797
Pubmed

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A.

CYP2A6 CYP2C19 CYP2C9

1.56e-07588319029318
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13

3.11e-0768837668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13

3.11e-0768838587134
Pubmed

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.

CYP2C19 CYP2C8 CYP2C9

3.11e-07688317635176
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.49e-075788532633719
Pubmed

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.81e-075888530377227
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13

5.44e-07788314630516
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

5.44e-0778839630227
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

CYP2A6 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CHST1

6.31e-0719388719343046
Pubmed

Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.

CYP2A6 CYP2C19 CYP2C8 CYP2C9

6.42e-072788420173083
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PDS5B ZNF131 LIG3 KIF23 TJP1 PRRC2C DKC1 SMARCC2 PDS5A MCCC1 SMC5 YY1 RCC2

8.25e-07954881336373674
Pubmed

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

8.50e-076888511230163
Pubmed

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.

CYP2A6 CYP2C19 CYP2C9

8.69e-07888318356043
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.13e-067288510380929
Pubmed

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.30e-067488510817752
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.58e-067788510835267
Pubmed

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.

PDS5B PDS5A SMC5

1.85e-061088322751501
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

CYP2C19 CYP2C8 CYP2C9

1.85e-061088320602612
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.91e-068088510716726
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

LIG3 ZKSCAN3 SMARCC2 PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.96e-0632988817474147
Pubmed

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PCDHA10 PCDHA7 PCDHA5

2.55e-06118839655502
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

LIG3 TJP1 PRRC2C EVPL MCCC1 SMC5 MVP IQGAP1

3.81e-0636088833111431
Pubmed

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.

CYP2C19 SAMD9L CYP2C8 PRRC2C DOCK7

4.48e-069588524029230
Pubmed

Toward personalized medicine in renal transplantation.

CYP2C19 CYP2C8 CYP2C9

5.58e-061488320970553
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

6.33e-06288222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

6.33e-06288216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

6.33e-06288215998580
Pubmed

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

CYP2C8 CYP2C9

6.33e-0628827574697
Pubmed

Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid.

CYP2C9 UGT1A6

6.33e-06288216305586
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

6.33e-0628827373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

6.33e-06288219062096
Pubmed

CYP2C9, but not CYP2C19, polymorphisms affect the pharmacokinetics and pharmacodynamics of glyburide in Chinese subjects.

CYP2C19 CYP2C9

6.33e-06288216198656
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

6.33e-0628823696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

6.33e-0628821357031
Pubmed

Individuals with CYP2C8 and CYP2C9 reduced metabolism haplotypes self-adjusted ibuprofen dose in the Coriell Personalized Medicine Collaborative.

CYP2C8 CYP2C9

6.33e-06288230562214
Pubmed

Effect of gender and CYP2C9 and CYP2C8 polymorphisms on the pharmacokinetics of ibuprofen enantiomers.

CYP2C8 CYP2C9

6.33e-06288226122864
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

6.33e-06288216098595
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

6.33e-06288212325023
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

6.33e-06288219933335
InteractionPCDHA10 interactions

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.32e-0822875int:PCDHA10
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

7.77e-083873int:CYP2A7
InteractionFMR1 interactions

KIF23 TJP1 PRRC2C DOCK7 DKC1 SMARCC2 MAGI3 ZNFX1 MVP CNOT1 USP33 IQGAP1

3.21e-065368712int:FMR1
InteractionLGR4 interactions

PRRC2C AGL DOCK7 CYP2U1 EIF4G3 CNOT1 CDKAL1 IQGAP1

1.77e-05262878int:LGR4
InteractionPCDHA7 interactions

PCDHA10 PCDHA7 PCDHA2

2.73e-0514873int:PCDHA7
InteractionPCDHA2 interactions

PCDHA10 PCDHA7 PCDHA2

2.73e-0514873int:PCDHA2
Cytoband5q31

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

3.00e-061158855q31
Cytoband15q21

SPTBN5 MAPK6

1.98e-041188215q21
CytobandEnsembl 112 genes in cytogenetic band chr5q31

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

2.81e-04298885chr5q31
Cytoband10q24

CYP2C19 CYP2C9

2.07e-033588210q24
Cytoband1p36.12

EIF4G3 KIF17

2.57e-03398821p36.12
Cytoband19q13.2

CYP2A6 CYP2A7 CYP2A13

3.93e-0316488319q13.2
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP2U1

2.18e-11356171001
GeneFamilyClustered protocadherins

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

2.42e-066461520
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2

3.35e-053612297
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

3.97e-0496121234
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

TJP1 MAGI3

3.45e-0326612904
GeneFamilyComplement system|Sushi domain containing

C4A C4B

6.55e-0336612492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

6.91e-0337612454
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF23 KIF17

1.05e-0246612622
CoexpressionWENG_POR_DOSAGE

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C9

4.79e-0830875MM1199
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

PDS5B PDS5A AKAP11 MAPK6 RRM2 CNOT1 IQGAP1

2.02e-05250877M11318
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C PDS5A AKAP11 SMC5 YY1 IQGAP1 ITPR2

4.38e-0919188860c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C PDS5A AKAP11 SMC5 YY1 IQGAP1 ITPR2

4.38e-09191888973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Nnat_(Neuron.Gad1Gad2.Synpr-Nnat)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

KCNH6 MYO3A FNDC9 PCDHA7 PCDHA2

7.40e-0785885642755ed2b562dd5e599a04a2b9730e8d29aefe8
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Nnat_(Neuron.Gad1Gad2.Synpr-Nnat)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

KCNH6 MYO3A FNDC9 PCDHA7 PCDHA2

7.40e-07858852429bacccd103e5b2414264b4aff3103ed9d7cec
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C PDS5A AKAP11 YY1 IQGAP1

2.20e-0619188609db184cb90fe282a14474d7217068c58092c6f8
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

DCDC2 PRRC2C MAGI3 CDKAL1 ACSS3 ITPR2

2.33e-06193886e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP100 LIG3 DCDC2 PDS5A CYP2U1

2.09e-05168885d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_proximal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SPTBN5 COL7A1 CYP2A13 UGT1A6 FSBP

2.75e-051788859534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C EIF4G3 ABCA9 IQGAP1

3.06e-05182885f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

CYP2U1 ADAMTSL3 ABCA9 ACSS3 ITPR2

3.22e-0518488567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C PDS5A EIF4G3 IQGAP1

3.22e-051848851154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PRRC2C EIF4G3 ABCA9 IQGAP1

3.31e-051858857adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

DCDC2 MAGI3 CDKAL1 ACSS3 ITPR2

3.95e-05192885916fbec1c7ab7969bda711886ac88e877e30c280
ComputationalGenes in the cancer module 135.

CYP2A6 CYP2C19 CYP2C8 CYP27A1

4.49e-0625494MODULE_135
ComputationalCytochrome P450.

CYP2C19 CYP2C8 CYP2C9

3.13e-0514493MODULE_106
ComputationalNeighborhood of CYP2B6

CYP2A6 CYP2C8 CYP2C9 CYP27A1

6.94e-0549494GNF2_CYP2B6
ComputationalNeighborhood of CEBPA

CYP2A6 CYP2C8 CYP2C9 CYP27A1

1.98e-0464494GNF2_CEBPA
ComputationalNeighborhood of IGF1

CYP2A6 CYP2C8 CYP2C9

2.15e-0426493GNF2_IGF1
Drugdiosmetin

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

1.09e-12858810CID005281612
Drugaminoglutethimide

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 AGL CYP27A1 CYP2U1 SNURF

1.35e-101378810CID000002145
DrugAC1L1KIN

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 MAPK6

1.81e-10100889CID000005516
Drugpropoxyphene

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.95e-1067888CID000010100
Drugcarteolol

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

3.52e-1072888CID000002583
DrugAC1Q7AUJ

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

7.44e-10117889CID000003303
Drugtrimipramine

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

8.32e-1080888CID000005584
Drugfelodipine

CACNA1E CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 ITPR1

1.07e-091698810CID000003333
Drughexobarbital

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

1.55e-09127889CID000003608
Drugmephenytoin

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.80e-0988888CID000004060
DrugBP-7,8-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

2.34e-0932886CID000037455
Drugtienilic acid

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.80e-0993888CID000038409
Druglansoprazole

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

2.80e-0993888CID000003883
Drug1-naphthol

CYP2A6 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6

2.86e-0933886ctd:C029350
Drugtolbutamide

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 AGL CYP27A1 CYP2U1 AKT2

4.94e-091988810CID000005505
DrugSparteinum

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

5.43e-09101888CID000003966
DrugN-NK

BLMH CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CHRNA1

5.99e-09148889CID000047289
DrugD 703

CYP2A6 CYP2A13 CYP2C19 CYP2C8 CYP2C9

6.33e-0918885CID000054088
Drugdiclofenac

PDS5B CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

8.29e-092098810CID000003032
Drug1h1q

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6

9.95e-0970887CID000001540
Drugparaoxon

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 CHRNA1

1.47e-08164889CID000009395
Drugpolybrominated biphenyl

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.76e-0844886CID000042948
Drug8-MOP

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

1.86e-08118888CID000004114
Drugazoline

CYP2A6 CYP2C19 CYP2C8 CYP2C9 C4A

1.92e-0822885CID003013050
Drugbenzphetamine

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1

1.99e-08119888CID000002341
Drugaminopyrine

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

2.12e-08171889CID000006009
DrugTryptamines

CYP2A6 CYP2C19 CYP2C8 CYP2C9

2.59e-089884ctd:D014363
Drug5-chlorotryptamine

CYP2A6 CYP2C19 CYP2C8 CYP2C9

2.59e-089884ctd:C529169
Drug19-HETE

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

3.43e-0849886CID006439528
Drughalothane

CACNA1E CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 CHRNA1 ITPR1

3.59e-083148811CID000003562
Drugchloral hydrate

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

3.75e-08129888CID000002707
Drugmethylpropylnitrosamine

BLMH CYP2A6 CYP2C19 CYP2C8 CYP2C9

3.84e-0825885CID000013545
DrugTranylcypromine

CYP2A6 CYP2A13 CYP2C19 CYP2C8 CYP2C9

3.84e-0825885ctd:D014191
Drug6-hydroxymelatonin

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

3.89e-0850886CID000001864
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

5.58e-083883CID000068481
DrugBP-9,10-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

5.80e-0827885CID000037456
DrugBrn 4136738

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

5.80e-0827885CID000050331
DrugC14845

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

5.80e-0827885CID011954064
Drugtrans-1,2-dihydro-1,2-naphthalenediol

CYP2A6 CYP2C19 CYP2C8 CYP2C9

6.73e-0811884ctd:C507866
Drugnifedipine

CACNA1E CYP2A6 CYP2A7 COL7A1 MYO3A CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 ITPR1

6.76e-084158812CID000004485
Drug9-OH-BaP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

7.04e-0828885CID000115064
Druganiline

PDS5B CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6

7.93e-08142888CID000006115
Drug7-hydroxy-4-trifluoromethylcoumarin

CYP2A6 CYP2C19 CYP2C8 CYP2C9 UGT1A6

8.49e-0829885CID005375667
Drugbromobenzene

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9 SPAG17 PDCD1LG2

9.80e-0897887CID000007961
Drug19-hydroxytestosterone

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.02e-0730885CID000150968
Drug11-H-14,15-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.02e-0730885CID011954058
DrugPCB 77

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 EVPL

1.05e-0798887CID000036187
DrugBP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.31e-0761886CID000037786
Drug7-hydroxyquinoline

CYP2A6 CYP2C19 CYP2C8 CYP2C9

1.45e-0713884CID000011378
Drug1'-hydroxymidazolam

CYP2A6 CYP2C19 CYP2C8 CYP2C9

1.45e-0713884CID000107917
Drugchlorzoxazone

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

1.60e-0763886CID000002733
Drug12(13)-EpOME

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.96e-0734885CID000001416
DrugTCEO

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.96e-0734885CID000028167
DrugAC1O5XSP

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.96e-0734885CID006442739
DrugAC1L1CJI

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

2.28e-0735885CID000001929
Drugpiperonyl butoxide

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

2.32e-0767886CID000005794
Drugcaffeine

CACNA1E CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 CNOT1 CHRNA1 RCC2 ITPR1

2.43e-075628813CID000002519
Drug5,6-epoxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

2.53e-0768886CID000001778
Drug15-H-11,12-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

2.64e-0736885CID011954042
DrugAC1L3NGJ

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

2.64e-0736885CID000092121
Drug2'-(glutathion-S-yl)-deschlorodiclofenac

CYP2A6 CYP2C19 CYP2C8 CYP2C9

2.75e-0715884ctd:C586542
Drug4-hydroxymephenytoin

CYP2A6 CYP2C19 CYP2C8 CYP2C9

2.75e-0715884CID000119507
Drug8(9)-EET

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

2.77e-0769886CID000001901
Drugrifampicin

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1 CHST1

2.97e-073068810CID005381226
Drug1-aminobenzotriazole

CYP2A6 CYP2A13 CYP2C19 CYP2C9 CYP27A1 MCCC1

3.28e-0771886CID000001367
Drug3 -hydroxypregn-5-en-20-one

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1 CYP2U1

3.57e-07238889CID000001027
DrugHCFC-141b

CYP2A6 CYP2C19 KIF23 CYP2C8

3.66e-0716884CID000015586
Drug6-hydroxychlorzoxazone

CYP2A6 CYP2C19 CYP2C8 CYP2C9

3.66e-0716884CID000002734
Drug1-phenylazo-2-naphthol

CYP2A6 CYP2C19 CYP2C8 CYP2C9

3.66e-0716884ctd:C024336
Drug2,2,2-trichloroethanol

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9 UGT1A6

3.88e-0773886CID000008259
Drug11,14,15-THET

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

3.99e-0739885CID006439531
Drug7-hydroxycoumarin

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C9 UGT1A6

4.56e-0775886CID005281426
Drugdebrisoquine

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

4.56e-0775886CID000002965
Drugmetyrapone

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

4.69e-07179888CID000004174
DrugN-benzylformamide

CYP2A6 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1

4.94e-0776886CID000080654
Drugfurafylline

CYP2A6 CYP2C19 CYP2C8 CYP2C9 MCCC1

5.16e-0741885CID000003433
Drugbufuralol

CYP2C19 CYP2C8 CYP2C9

5.55e-075883ctd:C010831
DrugC20H32O4

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

5.76e-0778886CID000001440
DrugBP-7,8-diol

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9

5.76e-0778886CID000025892
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

5.84e-0742885CID006439610
DrugL 654969

CYP2A6 CYP2C19 CYP2C8 CYP2C9 UGT1A6

5.84e-0742885CID000005218
Drug7-benzyloxyquinoline

CYP2A6 CYP2C19 CYP2C8 CYP2C9

6.12e-0718884CID003035604
Drug2,4-oxazolidinedione

CYP2A6 CYP2C19 CYP2C8 CYP2C9

6.12e-0718884CID000097389
Drugsulfaphenazole

CYP2A6 CYP2C19 CYP2C8 CYP2C9 MCCC1

7.41e-0744885CID000005335
Drughydroxytolbutamide

CYP2A6 CYP2C19 CYP2C8 CYP2C9

7.72e-0719884CID000003656
Drug6|A-Hydroxycortisol

CYP2A6 CYP2C19 CYP2C8 CYP2C9

7.72e-0719884CID000150985
DrugD 617

CYP2A6 CYP2A13 CYP2C8 CYP2C9

7.72e-0719884CID000093168
Drugalprazolam

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1

8.30e-07193888CID000002118
Drugnaphthalene-1,2-dihydrodiol

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

8.32e-0745885CID000000362
Drugdeferoxamine

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 CYP2U1 MAPK6 RRM2

8.42e-073438810CID000002973
Drugbufuralol

BLMH CYP2A6 CYP2C19 CYP2C8 CYP2C9

9.30e-0746885CID000071733
DrugN'-nitrosoanatabine

CYP2A6 CYP2C19 CYP2C8 CYP2C9

9.63e-0720884CID000051291
Drug3C etc

CYP2A6 CYP2C19 CYP2C8 CYP2C9

9.63e-0720884CID000164045
Drugtamoxifen N-oxide

CYP2A6 CYP2C19 CYP2C8 CYP2C9

9.63e-0720884CID003033895
Drug3-methoxymorphinan

CYP2A6 CYP2C19 CYP2C8 CYP2C9

9.63e-0720884CID000001671
DrugAC1Q6O8T

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 CYP27A1 C4A

9.69e-07197888CID000002193
DrugC14802

CYP2A6 CYP2A7 CYP2A13 CYP2C8 CYP2C9

1.04e-0647885CID011954053
Drugbeta-naphthoflavone

CYP2A6 CYP2A7 CYP2A13 CYP2C19 CYP2C8 CYP2C9 UGT1A6 CYP27A1

1.09e-06200888CID000002361
Drug4,4'-cyclohexylidenebisphenol

CYP2C19 CYP2C8 CYP2C9

1.11e-066883ctd:C570106
Drug4',5-dihydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9

1.11e-066883CID003052567
Disease1,5 anhydroglucitol measurement

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

1.98e-0829855EFO_0008009
Diseaseneutrophil count, basophil count

CSNK1G1 EML6 PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2 CDKAL1

2.83e-07224858EFO_0004833, EFO_0005090
Diseasevisceral adipose tissue measurement, body mass index

PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2

5.40e-0687855EFO_0004340, EFO_0004765
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

8.20e-062852C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

8.20e-062852C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

8.20e-062852C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

8.20e-062852C1140716
DiseaseX-21258 measurement

CYP2C19 CYP2C9

2.46e-053852EFO_0800802
DiseaseCOUMARIN RESISTANCE

CYP2A6 CYP2C9

2.46e-053852122700
DiseaseWarfarin response

CYP2A6 CYP2C9

2.46e-053852cv:C0750384
DiseaseColorectal Carcinoma

CYP2A6 LIG3 COL7A1 GDAP1L1 ZKSCAN3 MCF2L2 RRM2 SPAG17 ADAMTSL3 ABCA9

3.42e-057028510C0009402
Diseasepulse pressure measurement

LIG3 CYP2C9 LCA5L PRKAG1 PCDHA10 PCDHA7 UNC13D PCDHA5 PCDHA3 PCDHA2 ADAMTSL3 YY1 CNOT1 CDKAL1

4.16e-0513928514EFO_0005763
DiseaseCoumarin Resistance

CYP2A6 CYP2C9

4.90e-054852C0750384
Diseasepost-traumatic stress disorder symptom measurement

PCDHA7 PCDHA5 PCDHA3 PCDHA2

9.45e-0582854EFO_0008535
Diseasemetabolite measurement

CYP2A6 CYP2C8 CYP2C9 UGT1A6 CYP27A1 MCCC1 CDKAL1 ITPR2

2.14e-04560858EFO_0004725
Diseasehypoglycemia (is_implicated_in)

CYP2C9 AKT2

2.27e-048852DOID:9993 (is_implicated_in)
Diseaseneuroticism measurement, cognitive function measurement

CACNA1E PCDHA10 PCDHA7 PCDHA5 PCDHA3 PCDHA2 EIF4G3 USP33

2.30e-04566858EFO_0007660, EFO_0008354
DiseaseX-11308 measurement

CYP2C19 CYP2C9

4.44e-0411852EFO_0800693
Diseaseacute insulin response measurement

CHST1 CDKAL1

4.44e-0411852EFO_0006831
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2

5.31e-0412852DOID:1441 (implicated_via_orthology)
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7

5.31e-0412852EFO_0007794
Diseasethymol sulfate measurement

CYP2C19 CYP2C9

5.31e-0412852EFO_0021170
Diseasepeak insulin response measurement

CHST1 CDKAL1

6.27e-0413852EFO_0008000
Diseasealkaline phosphatase measurement

CYP2A6 CYP2A7 MYO3A DCDC2 CYP2C9 EIF4G3 KIF17 CNOT1 ITPR1 PDCD1LG2

6.72e-0410158510EFO_0004533
Diseaseunipolar depression

CACNA1E DCDC2 ZKSCAN3 UNC13D PCDHA5 PCDHA3 PCDHA2 EIF4G3 CDKAL1 ACSS3 ITPR2

6.79e-0412068511EFO_0003761
DiseaseN-acetylmethionine measurement

CHST1 ITPR1

8.40e-0415852EFO_0021427
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP2C8 CYP2C9

8.40e-0415852EFO_0800301
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP2C8 CYP2C9

9.59e-0416852EFO_0800305
Diseaseserum hepcidin measurement

EML6 AKAP11

1.22e-0318852EFO_0004504
DiseaseColorectal Neoplasms

CYP2A6 COL7A1 ZKSCAN3 RRM2 ABCA9

1.25e-03277855C0009404
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7

1.36e-0319852EFO_0007872
Diseasedepressive symptom measurement

CACNA1E ZKSCAN3 PCDHA5 PCDHA3 PCDHA2 EIF4G3

1.46e-03426856EFO_0007006
DiseaseDrug toxicity

CYP2C8 CYP2C9 HSPB6

1.86e-0384853C0013221
DiseaseAdverse reaction to drug

CYP2C8 CYP2C9 HSPB6

1.86e-0384853C0041755
Diseaseneutrophil count

CSNK1G1 EML6 MAGI3 PCDHA10 PCDHA7 PCDHA5 AKAP11 PCDHA3 PCDHA2 CDKAL1 ITPR2

2.03e-0313828511EFO_0004833
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

CYP2C19 CYP2C8 CYP2C9

2.12e-0388853EFO_0803332
Diseasesystemic mastocytosis

CACNA1E CDKAL1

2.36e-0325852MONDO_0016586
DiseaseC-reactive protein measurement

CYP2A6 CYP2A7 DNAH17 POC1B DOCK7 SMARCC2 CCDC168 MAPK6 EIF4G3 ITPR1

2.43e-0312068510EFO_0004458
DiseaseS-warfarin to R-warfarin ratio measurement

CYP2C19 CYP2C8 CYP2C9

2.64e-0395853EFO_0803331
Diseasepost-traumatic stress disorder

PCDHA7 PCDHA5 PCDHA3 PCDHA2

2.80e-03202854EFO_0001358

Protein segments in the cluster

PeptideGeneStartEntry
EVIIAKDEVAHTVTE

AKT2

186

P31751
EVHRLVVVDENDVVK

PRKAG1

296

P54619
HIVLVQEEIREPMEA

CDRT15L2

71

A8MXV6
PELEVGKHVVLTEQE

CACNA1E

1011

Q15878
PKVVEEQESRVHYTV

C4B

1456

P0C0L5
PEVEAKVHEEIDRVI

CYP2A6

321

P11509
PHEVEKEVQRVVQEL

ABCA9

591

Q8IUA7
HPEVTAKVQEEIDHV

CYP2C8

316

P10632
EEKLDIEAVVHPREV

AKAP11

1301

Q9UKA4
VTPEQALAHEEVKTR

IQGAP1

1116

P46940
AAVVITEPEHTKERV

RCC2

81

Q9P258
DPEEAIRHDVIVSIV

PDS5B

361

Q9NTI5
INTHILKVPETDEVE

PDCD1LG2

126

Q9BQ51
DPEEAIRHDVIVTII

PDS5A

371

Q29RF7
EEVPVIIHRDNIISD

GDAP1L1

96

Q96MZ0
IVRVVTHDDCIPEVK

ITPR2

1406

Q14571
VEVIVDRPLQVFHVE

PCDHA2

106

Q9Y5H9
DRPLQVFHVEVEVKD

PCDHA2

111

Q9Y5H9
SSVVRPVEDHRQVVE

CHRNA1

36

P02708
ERPLQVFHVDVEVKD

PCDHA7

111

Q9UN72
DRPLQVFHVEVEVKD

PCDHA3

111

Q9Y5H8
EEIAVKVVGEHVEVH

HSPB6

86

O14558
EESHVPVIEESLRVQ

MAGI3

1141

Q5TCQ9
VRVVTHEDCIPEVKI

ITPR1

1416

Q14643
EEKVPRTISSVVLEH

FNDC9

51

Q8TBE3
PITAHAEVEVVEEAK

CSNK1G1

391

Q9HCP0
TTEIEIIAPHKVVER

KCNH6

201

Q9H252
VITHVDEIMQQEVRP

MCF2L2

21

Q86YR7
VHEEDRQELLSVIPV

MAPK6

251

Q16659
PTVEYKEVTQEVVRH

EVPL

1246

Q92817
KEVTQEVVRHERSPE

EVPL

1251

Q92817
IVEHTEPRVAESQEL

KDM4E

341

B2RXH2
KIIEVIHPERESNQE

LCA5L

471

O95447
RTPHPHEEKVETVEI

POC1B

331

Q8TC44
EVIVDRPLQVFHVEV

PCDHA5

106

Q9Y5H7
VERVLHNAQEVEKEP

LIG3

451

P49916
VPSAKVEVVEERQAI

MVP

366

Q14764
RPLQVFHVDVEVKDI

PCDHA10

111

Q9Y5I2
NPDVQEKVHEEIERV

CYP2U1

371

Q7Z449
PEVEAKVHEEIDRVI

CYP2A13

321

Q16696
HPEVTAKVQEEIERV

CYP2C19

316

P33261
NVTHKEEIILTPIEV

DOCK7

1981

Q96N67
PQVVSEDIVKQVHRL

DNAH17

131

Q9UFH2
DRVVEVVEETIKGHS

CDKAL1

161

Q5VV42
PEVEAKVHEEIDRVI

CYP2A7

321

P20853
EIQEALHEEVVGVVP

CYP27A1

356

Q02318
LEHVPQVKIEQAERA

CFAP100

521

Q494V2
EVVVDRKHVPEEVLA

BLMH

421

Q13867
RKHVPEEVLAVLEQE

BLMH

426

Q13867
IEKFVDTPRHVEVQV

MCCC1

246

Q96RQ3
DEVVVTNTIPHEVQK

PRPSAP2

316

O60256
VPVLRVSHAEEEERV

COL7A1

2831

Q02388
VHEVPLGKQVTEAVV

EML6

1841

Q6ZMW3
QTKERIVPEHDVSRI

CCDC168

6241

Q8NDH2
HPEVTAKVQEEIERV

CYP2C9

316

P11712
EVVAEVVKAPQVVAE

DKC1

426

O60832
SDEIPVEHQVLVKRI

SCAMP4

26

Q969E2
EPRKIITVSVKEDVH

EIF4G3

711

O43432
EVVNTEVKPVIHSRI

DCDC2

111

Q9UHG0
PKVVEEQESRVHYTV

C4A

1456

P0C0L4
VVPTFRNEIEIEEDH

KIF23

776

Q02241
PVIQHDVEAEKQLIR

KIF17

396

Q9P2E2
THRKVPIVVTLVDDE

FREM3

1291

P0C091
DRFVIEVDTIPKHSI

SAMD9L

301

Q8IVG5
SVVIIDDHPEVTVIE

PRRC2C

1656

Q9Y520
EVPTALVEAHVRKVE

SMARCC2

706

Q8TAQ2
RVHFLQSVVVKVEEP

SPTBN5

1051

Q9NRC6
EQVKIQEVTEESPHQ

SPAG17

996

Q6Q759
TEEQVLEEIVKHVRQ

ACSS3

611

Q9H6R3
SHVAIKTVRVPEVND

CHST1

201

O43916
AIERAVQELVHPVVD

CNOT1

1396

A5YKK6
RRTTEQHVPEVEVQV

SNURF

11

Q9Y675
EEIEPEHEGRKVVVF

SPRYD3

386

Q8NCJ5
VHKPSEERVREIIIN

RRM2

281

P31350
VELHEIEVETIPVET

YY1

21

P25490
HPVAITVEVKQEEDI

FSBP

146

O95073
VVDIPEELVEEHDIT

MTHFSD

186

Q2M296
QKVEPRIVIVEEAAE

ZNFX1

996

Q9P2E3
DHTPKTVEEVTVERN

TJP1

361

Q07157
VQEHHPESREDVVVV

ZSCAN26

111

Q16670
VREQHPESGEEVVVL

ZKSCAN3

106

Q9BRR0
EELHVERVNQMPVEV

ZNF131

541

P52739
KTEVQEEEVVATPVH

ZNF746

286

Q6NUN9
DRGHEIVVVVPEVNL

UGT1A6

51

P19224
IHEVPVGTEKTRERI

SMC5

586

Q8IY18
VVELPVTERQIEREH

TBC1D10A

351

Q9BXI6
RQKAVVRHTIPEEET

UNC13D

156

Q70J99
VVHVDPDILQAEEKI

USP33

921

Q8TEY7
SHVSPEKREENVIAV

ADAMTSL3

236

P82987
DELVPHQISVVSEER

AGL

661

P35573
LRHETVKERQVEPVT

MYO3A

1326

Q8NEV4