Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	macropinocytosis	SNX33 APPL2 APPL1	2.00e-05	11	104	3	GO:0044351
GeneOntologyBiologicalProcess	positive regulation of macropinocytosis	APPL2 APPL1	2.52e-05	2	104	2	GO:1905303
Domain	-	DSP DST MACF1 PLEC	1.25e-08	6	102	4	3.90.1290.10
Domain	Plectin	DSP DST MACF1 PLEC	2.90e-08	7	102	4	PF00681
Domain	Plectin_repeat	DSP DST MACF1 PLEC	2.90e-08	7	102	4	IPR001101
Domain	PLEC	DSP DST MACF1 PLEC	2.90e-08	7	102	4	SM00250
Domain	Bromodomain	BRPF3 TRIM66 PBRM1 SP140L TAF1L EP300	5.48e-08	38	102	6	PF00439
Domain	BROMODOMAIN_2	BRPF3 TRIM66 PBRM1 SP140L TAF1L EP300	8.81e-08	41	102	6	PS50014
Domain	Bromodomain	BRPF3 TRIM66 PBRM1 SP140L TAF1L EP300	1.02e-07	42	102	6	IPR001487
Domain	BROMO	BRPF3 TRIM66 PBRM1 SP140L TAF1L EP300	1.02e-07	42	102	6	SM00297
Domain	-	BRPF3 TRIM66 PBRM1 SP140L TAF1L EP300	1.02e-07	42	102	6	1.20.920.10
Domain	BROMODOMAIN_1	BRPF3 TRIM66 PBRM1 TAF1L EP300	1.67e-06	37	102	5	PS00633
Domain	Bromodomain_CS	BRPF3 PBRM1 TAF1L EP300	1.14e-05	26	102	4	IPR018359
Domain	Spectrin_repeat	DSP DST MACF1 PLEC	1.79e-05	29	102	4	IPR002017
Domain	SPEC	DSP DST MACF1 PLEC	2.68e-05	32	102	4	SM00150
Domain	Spectrin/alpha-actinin	DSP DST MACF1 PLEC	2.68e-05	32	102	4	IPR018159
Domain	PX	SNX33 SNX13 PIK3C2G SNX10	9.62e-05	44	102	4	SM00312
Domain	PX	SNX33 SNX13 PIK3C2G SNX10	1.47e-04	49	102	4	PF00787
Domain	PX	SNX33 SNX13 PIK3C2G SNX10	1.59e-04	50	102	4	PS50195
Domain	-	SNX33 SNX13 PIK3C2G SNX10	1.72e-04	51	102	4	3.30.1520.10
Domain	SH3	SNX33 DOCK5 DST ARHGAP12 BTK ARHGEF9 MACF1	1.83e-04	216	102	7	PS50002
Domain	Phox	SNX33 SNX13 PIK3C2G SNX10	1.86e-04	52	102	4	IPR001683
Domain	SH3_domain	SNX33 DOCK5 DST ARHGAP12 BTK ARHGEF9 MACF1	2.05e-04	220	102	7	IPR001452
Domain	ACTININ_2	DST MACF1 PLEC	2.59e-04	23	102	3	PS00020
Domain	ACTININ_1	DST MACF1 PLEC	2.59e-04	23	102	3	PS00019
Domain	Actinin_actin-bd_CS	DST MACF1 PLEC	2.59e-04	23	102	3	IPR001589
Domain	PH	RASA3 APPL2 ARHGAP12 BTK ARHGEF9 APPL1 ACAP3	2.62e-04	229	102	7	PF00169
Domain	SH3_1	SNX33 DOCK5 DST ARHGAP12 BTK ARHGEF9	2.81e-04	164	102	6	PF00018
Domain	FerI	OTOF FER1L5	2.92e-04	5	102	2	SM01202
Domain	FerB	OTOF FER1L5	2.92e-04	5	102	2	SM01201
Domain	Ferlin_B-domain	OTOF FER1L5	2.92e-04	5	102	2	IPR012561
Domain	Ferlin_C	OTOF FER1L5	2.92e-04	5	102	2	PF16165
Domain	Ferlin_C	OTOF FER1L5	2.92e-04	5	102	2	IPR032362
Domain	FerIin_dom	OTOF FER1L5	2.92e-04	5	102	2	IPR012968
Domain	FerI	OTOF FER1L5	2.92e-04	5	102	2	PF08151
Domain	FerB	OTOF FER1L5	2.92e-04	5	102	2	PF08150
Domain	GAR	DST MACF1	4.37e-04	6	102	2	PS51460
Domain	GAS2	DST MACF1	4.37e-04	6	102	2	PF02187
Domain	-	DST MACF1	4.37e-04	6	102	2	3.30.920.20
Domain	GAS_dom	DST MACF1	4.37e-04	6	102	2	IPR003108
Domain	GAS2	DST MACF1	4.37e-04	6	102	2	SM00243
Domain	C2	RASA3 OTOF PIK3C2G CPNE4 FER1L5	7.60e-04	131	102	5	PF00168
Domain	PH	RASA3 APPL2 ARHGAP12 BTK ARHGEF9 APPL1 ACAP3	8.32e-04	278	102	7	SM00233
Domain	PH_DOMAIN	RASA3 APPL2 ARHGAP12 BTK ARHGEF9 APPL1 ACAP3	8.49e-04	279	102	7	PS50003
Domain	PH_domain	RASA3 APPL2 ARHGAP12 BTK ARHGEF9 APPL1 ACAP3	8.67e-04	280	102	7	IPR001849
Domain	C2	RASA3 OTOF PIK3C2G CPNE4 FER1L5	9.30e-04	137	102	5	SM00239
Domain	BTK	RASA3 BTK	1.04e-03	9	102	2	SM00107
Domain	Znf_Btk_motif	RASA3 BTK	1.04e-03	9	102	2	IPR001562
Domain	BTK	RASA3 BTK	1.04e-03	9	102	2	PF00779
Domain	ZF_BTK	RASA3 BTK	1.04e-03	9	102	2	PS51113
Domain	C2	RASA3 OTOF PIK3C2G CPNE4 FER1L5	1.09e-03	142	102	5	PS50004
Domain	-	RASA3 OTOF PIK3C2G CPNE4 FER1L5	1.31e-03	148	102	5	2.60.40.150
Domain	C2_dom	RASA3 OTOF PIK3C2G CPNE4 FER1L5	2.06e-03	164	102	5	IPR000008
Domain	VWF_A	CLCA4 MED25 CPNE4 SEC23A	2.12e-03	99	102	4	IPR002035
Domain	ZF_ZZ_2	DTNB EP300	4.27e-03	18	102	2	PS50135
Domain	ZF_ZZ_1	DTNB EP300	4.27e-03	18	102	2	PS01357
Domain	ZZ	DTNB EP300	4.27e-03	18	102	2	PF00569
Domain	Znf_ZZ	DTNB EP300	4.75e-03	19	102	2	IPR000433
Domain	ZnF_ZZ	DTNB EP300	4.75e-03	19	102	2	SM00291
Domain	Zinc_finger_PHD-type_CS	BRPF3 TRIM66 SP140L	5.41e-03	65	102	3	IPR019786
Domain	CH	DST MACF1 PLEC	5.41e-03	65	102	3	SM00033
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RASA3 DTNB POLG UVSSA FAF1 PCDHB16 DOCK5 NADSYN1 ZNF544 ARHGEF9 MACF1 EIF2AK4 DAAM1 GNAS PARD3 PLOD1 PCCA ZRANB1 EP300	1.34e-07	1489	107	19	28611215
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 RRAS2 ERCC6 RASA3 DSP FASTKD2 SNX33 USP5 DST G3BP1 CPSF1 MACF1 DDX60L PLEC PARD3 PLOD1 SEC23A	8.22e-07	1353	107	17	29467282
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DSP SFI1 TUBGCP4 FAF1 DOCK5 UCHL5 CPSF1 MACF1 GNAS PLEC SEC23A	1.91e-06	582	107	11	20467437
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MMS22L ZSCAN5A WDR81 ZNF112 PBRM1 CCNYL1 DST PLEC EP300	1.94e-06	363	107	9	14691545
Pubmed	Functional proteomics mapping of a human signaling pathway.	STARD13 ERCC6 RMND5A FAF1 USP5 PBRM1 DST CEP135 MACF1 DAAM1 PLEC	2.21e-06	591	107	11	15231748
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DSP DST PLEC	2.35e-06	9	107	3	12482924
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DSP DST PLEC	4.59e-06	11	107	3	12802069
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYH1 DTNB SNX33 CCNQ UNC119 DST BTK EIF2AK4 DDX60L PLEC PLOD1 TAF1L EP300	4.65e-06	910	107	13	36736316
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BRPF3 UVSSA FASTKD2 SFI1 DZIP1 DST EIF2AK4 DAAM1 KCNT1 ACAP3	5.72e-06	529	107	10	14621295
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	STARD13 RRAS2 DSP WDR81 DPP3 USP5 DST MACF1 GNAS PLEC PCCA SEC23A	7.42e-06	807	107	12	30575818
Pubmed	Genetic variability in adapter proteins with APPL1/2 is associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population.	APPL2 APPL1	9.38e-06	2	107	2	22340213
Pubmed	Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease.	APPL2 APPL1	9.38e-06	2	107	2	23977033
Pubmed	Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.	APPL2 APPL1	9.38e-06	2	107	2	26445298
Pubmed	APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy.	APPL2 APPL1	9.38e-06	2	107	2	20814572
Pubmed	K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment.	USP5 ZRANB1	9.38e-06	2	107	2	38870935
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	DST MACF1	9.38e-06	2	107	2	11002341
Pubmed	Lysine acetylation regulates Bruton's tyrosine kinase in B cell activation.	BTK EP300	9.38e-06	2	107	2	19949111
Pubmed	Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages.	APPL2 APPL1	9.38e-06	2	107	2	27219021
Pubmed	RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.	SNX13 GNAS	9.38e-06	2	107	2	11729322
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DSP DZIP1 FAF1 DST APPL2 MACF1 APPL1 PLEC PARD3	2.40e-05	497	107	9	23414517
Pubmed	BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.	DST PLEC	2.81e-05	3	107	2	19932097
Pubmed	Expression of the mouse Macf2 gene during inner ear development.	DST MACF1	2.81e-05	3	107	2	12399109
Pubmed	Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates β-catenin dependent transcriptional events.	APPL2 APPL1	2.81e-05	3	107	2	23891720
Pubmed	APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.	APPL2 APPL1	2.81e-05	3	107	2	24763056
Pubmed	Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.	APPL2 APPL1	2.81e-05	3	107	2	25328665
Pubmed	Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.	APPL2 APPL1	2.81e-05	3	107	2	18034774
Pubmed	The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.	APPL2 APPL1	2.81e-05	3	107	2	24879834
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	MYH1 MARCHF10 DSP SNX13 OR6T1 PLOD1	3.44e-05	197	107	6	23686814
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DSP USP5 PBRM1 DST G3BP1 CPSF1 MACF1 PLEC PLOD1 SEC23A	3.49e-05	653	107	10	22586326
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	RASA3 DZIP1 DST APPL2 MACF1 APPL1 DAAM1 PARD3	4.95e-05	421	107	8	36976175
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	UCHL5 CPSF1 APPL1 GNAS PLEC SEC23A	5.18e-05	212	107	6	33462405
Pubmed	Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.	APPL2 APPL1	5.60e-05	4	107	2	21645192
Pubmed	Genomic organization and chromosomal localization of the mouse snail (Sna) gene.	ADA GNAS	5.60e-05	4	107	2	9271672
Pubmed	Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.	APPL2 APPL1	5.60e-05	4	107	2	19661063
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	DST MACF1	5.60e-05	4	107	2	8954775
Pubmed	Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.	APPL2 APPL1	5.60e-05	4	107	2	25568335
Pubmed	Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.	DST PLEC	5.60e-05	4	107	2	14668477
Pubmed	Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase.	APPL2 APPL1	5.60e-05	4	107	2	23055524
Pubmed	Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.	ERCC6 UVSSA	5.60e-05	4	107	2	22466612
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	MYH1 DSP FASTKD2 SNX33 ADA DST G3BP1 MACF1 CPNE4 PLEC SEC23A	6.02e-05	844	107	11	25963833
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	DSP USP5 DST UCHL5 MACF1 HTR3B GNAS	6.46e-05	322	107	7	26514267
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BRPF3 TRIM66 PBRM1 EP300	8.70e-05	75	107	4	25593309
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DSP PBRM1 DST OTOF MACF1 PLEC	8.92e-05	234	107	6	36243803
Pubmed	APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.	APPL2 APPL1	9.32e-05	5	107	2	26583432
Pubmed	APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.	APPL2 APPL1	9.32e-05	5	107	2	17030088
Pubmed	Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.	ADA GNAS	9.32e-05	5	107	2	7490098
Pubmed	Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities.	USP5 G3BP1	9.32e-05	5	107	2	29567855
Pubmed	APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.	APPL2 APPL1	9.32e-05	5	107	2	16622416
Pubmed	Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene.	ADA GNAS	9.32e-05	5	107	2	8973343
Pubmed	Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene.	ADA GNAS	9.32e-05	5	107	2	8270638
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DSP SNX33 TUBGCP4 PBRM1 ARHGAP12 ELAVL3 PARD3 KCNT1	1.14e-04	475	107	8	31040226
Pubmed	Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function.	USP5 UCHL5 EP300	1.20e-04	31	107	3	36114200
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	RAD51D MMS22L ERCC6 UCHL5 EP300	1.29e-04	157	107	5	30686591
Pubmed	USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.	ERCC6 UVSSA	1.40e-04	6	107	2	31775559
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DSP POLG DZIP1 FAF1 TRIM66 DST APPL2 OTOF SBNO1 MACF1 APPL1 PLEC EP300	1.63e-04	1285	107	13	35914814
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	DPP3 MACF1 PLEC	1.88e-04	36	107	3	16097034
Pubmed	Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X.	ADA GNAS	1.95e-04	7	107	2	1450513
Pubmed	The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.	DST PLEC	1.95e-04	7	107	2	10637308
Pubmed	Structural basis of human transcription-DNA repair coupling.	ERCC6 UVSSA	1.95e-04	7	107	2	34526721
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	RAD51D AEN BRPF3 DOLPP1 FAM186B PBRM1 SBNO1 SPRING1 CEP135 CPSF1 EIF2AK4 ZRANB1 EP300	2.23e-04	1327	107	13	32694731
Pubmed	Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts.	APPL2 APPL1	2.59e-04	8	107	2	20040596
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD18B ANKRD18A	2.59e-04	8	107	2	12634303
Pubmed	Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.	MYH1 EP300	2.59e-04	8	107	2	36200826
Pubmed	Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.	APPL2 APPL1	2.59e-04	8	107	2	19433865
Pubmed	Epidermolysis Bullosa Simplex	DST PLEC	2.59e-04	8	107	2	20301543
Pubmed	Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.	EP300 SEC23A	2.59e-04	8	107	2	27018634
Pubmed	Genomic analysis of mouse retinal development.	RASA3 CCNQ FEM1B UNC119 DST APPL2 G3BP1 PIK3C2G PLEC PCCA ZRANB1	2.78e-04	1006	107	11	15226823
Pubmed	An unappreciated role for RNA surveillance.	RAD51D DTNB DPP3 SNX13	2.85e-04	102	107	4	14759258
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DSP SNX33 PBRM1 G3BP1 BHLHA15 UCHL5 CPSF1 EIF2AK4 GNAS PLEC PARD3 PLOD1 SEC23A	3.05e-04	1371	107	13	36244648
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RRAS2 DSP PBRM1 DST G3BP1 CPSF1 MACF1 GNAS PLEC PLOD1 SEC23A	3.23e-04	1024	107	11	24711643
Pubmed	The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.	ADA EP300	3.33e-04	9	107	2	14612417
Pubmed	Assembly and specific recognition of k29- and k33-linked polyubiquitin.	AREL1 ZRANB1	3.33e-04	9	107	2	25752577
Pubmed	APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.	APPL2 APPL1	3.33e-04	9	107	2	15016378
Pubmed	Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.	DSP PLEC	3.33e-04	9	107	2	15500642
Pubmed	Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.	USP5 UCHL5	3.33e-04	9	107	2	27066941
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	RRAS2 DSP UBA2 DOLPP1 NDUFV1 FAF1 USP5 G3BP1 UCHL5 SEC23A	3.87e-04	878	107	10	37223481
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	RRAS2 WDR81 SNX33 SNX13 FEM1B USP5 PBRM1 MACF1 PARD3	3.89e-04	719	107	9	35337019
Pubmed	Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins.	UBA2 USP5	4.15e-04	10	107	2	14673145
Pubmed	CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.	BEND5 FASTKD2 ZNF112 UNC119 BHLHA15 ARHGEF9 GNAS	4.35e-04	440	107	7	35156780
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	ERCC6 UCHL5 CEP135 EP300	4.65e-04	116	107	4	21282530
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	RAD51D POLG ELFN2 TRIM66 SBNO1 APPL1 PCCA	4.97e-04	450	107	7	16751776
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	DST MACF1	5.06e-04	11	107	2	16815997
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	DST PLEC	5.06e-04	11	107	2	10811835
Pubmed	Current insights into the formation and breakdown of hemidesmosomes.	DST PLEC	5.06e-04	11	107	2	16757171
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RMND5A NADSYN1 DST UCHL5 ZRANB1	5.16e-04	212	107	5	33853758
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	STARD13 RRAS2 DSP FASTKD2 SNX33 NDUFV1 CPSF1 GNAS PLEC PLOD1 PCCA EP300 SEC23A	5.22e-04	1451	107	13	30550785
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	DST ZNF544 CEP135 MACF1	5.29e-04	120	107	4	31413325
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	UBA2 DPP3 FAF1 USP5 APPL2 G3BP1 SBNO1 UCHL5 MACF1 APPL1 PLEC PLOD1 SEC23A	5.35e-04	1455	107	13	22863883
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DSP CARD8 DOCK5 USP5 UCHL5 CPSF1 PLOD1 ZRANB1 EP300	5.47e-04	754	107	9	35906200
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	MYH1 DSP NDUFV1 DST PLEC PCCA	5.73e-04	331	107	6	29199018
Pubmed	Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.	APPL2 APPL1	6.07e-04	12	107	2	20665729
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DSP UBA2 SNX33 CCNYL1 G3BP1 CPSF1 APPL1 PLEC PARD3	6.59e-04	774	107	9	15302935
Pubmed	Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.	USP5 ZRANB1	7.15e-04	13	107	2	19373254
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	DST PLEC	7.15e-04	13	107	2	22962592
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	DST PLEC	7.15e-04	13	107	2	9670011
Pubmed	Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family.	ADA GNAS	7.15e-04	13	107	2	7959737
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	FAF1 USP5 DST UCHL5 MACF1 PLEC ZRANB1	7.36e-04	481	107	7	28190767
Pubmed	Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.	SFI1 TUBGCP4 CEP135	7.72e-04	58	107	3	12852856
Pubmed	Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method.	FAF1 USP5 UCHL5	7.72e-04	58	107	3	19013454
Pubmed	A human MAP kinase interactome.	DSP DST BTK ARHGEF9 MACF1 PLEC EP300	7.82e-04	486	107	7	20936779
Cytoband	1p33	BEND5 DMBX1 FAF1	7.63e-05	35	107	3	1p33
GeneFamily	EF-hand domain containing\|Plakins	DSP DST MACF1 PLEC	1.51e-08	8	71	4	939
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASA3 APPL2 ARHGAP12 BTK ARHGEF9 APPL1 ACAP3	1.61e-05	206	71	7	682
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	APPL2 APPL1 ACAP3	3.79e-05	17	71	3	1291
GeneFamily	Ferlin family	OTOF FER1L5	2.26e-04	6	71	2	828
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DTNB EP300	2.23e-03	18	71	2	91
GeneFamily	PHD finger proteins	BRPF3 TRIM66 SP140L	5.34e-03	90	71	3	88
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	WDR81 SFI1 ELFN2 PARD3	5.60e-03	181	71	4	694
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX13 SNX10	5.76e-03	29	71	2	754
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	UBA2 FASTKD2 DPP3 TUBGCP4 ADA CARD8 FAF1 SNX13 FEM1B SLC25A32 YJU2 ZNF544 ARHGAP12 BTK MACF1 APPL1 DAAM1	6.51e-06	1215	105	17	M41122
Drug	pioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A	BEND5 NR2F1 UNC119 YJU2 ARHGEF9 CEP135 MED25 PLEC	3.55e-06	194	106	8	6893_DN
Disease	UV-Sensitive Syndrome	ERCC6 UVSSA	3.68e-05	3	104	2	C1833561
Disease	UV-sensitive syndrome (is_implicated_in)	ERCC6 UVSSA	3.68e-05	3	104	2	DOID:0060240 (is_implicated_in)
Disease	Malignant neoplasm of breast	MYH1 RTP1 ERCC6 ZNF569 NR2F1 PBRM1 OTOF SBNO1 BTK MACF1 APPL1 PLOD1 EP300	1.04e-04	1074	104	13	C0006142
Disease	chemokine (C-C motif) ligand 27 measurement	STARD13 ANKRD18B PBRM1 TAF1L	1.12e-04	70	104	4	EFO_0008082
Disease	seasonality measurement, vitamin D measurement	RRAS2 SEC23A	1.22e-04	5	104	2	EFO_0004631, EFO_0006876
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST PLEC	2.55e-04	7	104	2	DOID:4644 (is_implicated_in)
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	OTOF FER1L5	2.55e-04	7	104	2	DOID:11724 (implicated_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of breast	PBRM1 BTK EP300	4.11e-04	41	104	3	C0496956
Disease	Breast adenocarcinoma	PBRM1 BTK EP300	4.11e-04	41	104	3	C0858252
Disease	body surface area	RRAS2 BRPF3 DOCK5 TRIM66 MACF1 GNAS CPNE4 PLEC PARD3	4.58e-04	643	104	9	EFO_0022196
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	LVRN SLCO4C1	6.63e-04	11	104	2	EFO_0801871
Disease	Mitochondrial Diseases	POLG FASTKD2 NDUFV1	6.97e-04	49	104	3	C0751651
Disease	vitamin D measurement, COVID-19	RRAS2 NADSYN1 SEC23A	6.97e-04	49	104	3	EFO_0004631, MONDO_0100096
Disease	brain measurement, neuroimaging measurement	RRAS2 NR2F1 FAF1 PBRM1 SBNO1 MACF1 PLEC PARD3	7.46e-04	550	104	8	EFO_0004346, EFO_0004464
Disease	fibrinogen measurement, factor VII measurement	SNX13 PLEC PARD3	1.14e-03	58	104	3	EFO_0004619, EFO_0004623
Disease	serum albumin measurement	RASA3 WDR81 SNX13 SBNO1 MACF1 EIF2AK4 CPNE4 PLEC	1.19e-03	592	104	8	EFO_0004535
Disease	colorectal cancer (is_marker_for)	ERCC6 ADA PBRM1 BTK	2.35e-03	157	104	4	DOID:9256 (is_marker_for)
Disease	Intrahepatic Cholangiocarcinoma	PBRM1 GNAS	3.23e-03	24	104	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PBRM1 GNAS	3.23e-03	24	104	2	C3805278

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLRNYQQQQEEMRHL	BEND5	186	Q7L4P6
QHQRFMARKALLQEQ	AEN	36	Q8WTP8
AETQRQMAHVQIFQR	EP300	1936	Q09472
LARLRAELVEMHFQN	AARD	101	Q4LEZ3
QALYNRLRQENMHFE	ADA	246	P00813
LLFAINSRRQHMVEF	ANKRD18A	171	Q8IVF6
RNRQIYEHNEAALFM	EIF2AK4	1091	Q9P2K8
LREMRHRFQTQQLLE	BTK	486	Q06187
FAQIQFNVVMRRHPL	HTR3B	226	O95264
QRMHKLNNAFQALRE	BHLHA15	86	Q7RTS1
LLFAINSRRQHMVEF	ANKRD18B	171	A2A2Z9
YHMILFDQAQRSVRQ	ACAP3	91	Q96P50
LSFQRKNQFMQRLHN	BRPF3	491	Q9ULD4
HHQTQRFRLDNLLNM	ELAVL3	231	Q14576
RLHFQQFMEVLESRR	FAM186B	276	Q8IYM0
VNRSMRVFIDHGNQL	FAM187A	316	A6NFU0
QQFFSNMLEEHQRIR	LVRN	946	Q6Q4G3
LLMLRVLRFQVSFQH	CCNQ	126	Q8N1B3
EMERHFLELLQFNIN	CCNYL1	271	Q8N7R7
DLLVEMRNFIAFQAH	ERCC6	1426	Q03468
QQRVFFLFDHQMVLC	ARHGEF9	336	O43307
IDNFRRTALMLAVQH	ANKRD19P	196	Q9H560
RIQVVHAFDIFQMLD	RAD51D	166	O75771
NMENLRQYVDRVFHA	RASA3	426	Q14644
RVVAFMDHIRIFQEQ	NR2F1	291	P10589
RFRDLNHYMEQILNV	PIK3C2G	1276	O75747
TIHRAARMSFRQLFQ	KIAA0895L	341	Q68EN5
QVVRARLQDQHMFYS	SLC25A32	246	Q9H2D1
NNRYRRLDLFQEHMF	PBRM1	831	Q86U86
LFLYLRMHQTNNARF	DOLPP1	116	Q86YN1
FLQAVLARIRSMHQQ	MMS22L	671	Q6ZRQ5
GRMRFHRLQNVQIAL	DST	86	Q03001
QFEMRRRLHYNEELN	PPP1R2C	136	O14990
RQILAARAIHNIFRM	APPL1	526	Q9UKG1
ENMINDFHRAILRTQ	KCNT1	231	Q5JUK3
HAVFFREMTQLILNE	DDX60L	6	Q5H9U9
LRFAQVFSQMIHLNE	FEM1B	386	Q9UK73
FRMLHVDRRTLQNAV	CPSF1	1381	Q10570
FAERLLMQFNHRLTQ	POLG	961	P54098
QAHMQARFVILRVLL	DPP3	566	Q9NY33
RNSRMVQFHFTNKDL	MED25	466	Q71SY5
RLRNHMAFLVDNLQY	TUBGCP4	516	Q9UGJ1
IQLNHANRMAAEALR	MYH1	1631	P12882
FQLRAQHFQENSRMP	PCCA	536	P05165
MRFHRLQNVQIALDF	MACF1	131	Q9UPN3
NIRQQDVFMFLTNRH	PLOD1	486	Q02809
NQDTMQILFRHLRRV	ARHGAP12	776	Q8IWW6
MHNRRQRQVLVFFVL	PCDHB16	6	Q9NRJ7
NQDLLDRFQMLHNRA	CEP135	876	Q66GS9
LFEMSRINHYQQRLQ	DAAM1	761	Q9Y4D1
MTQNRVFLRAINQFA	DOCK5	1011	Q9H7D0
LSLFRLQEQFRQHMA	DMBX1	261	Q8NFW5
NNQALRRFMQTFVLA	G3BP1	101	Q13283
IFRMNDDATQQLVHR	CPNE4	181	Q96A23
ASFERMDHLRQLQNI	DSP	261	P15924
AAFVKENHRQLQARM	CARD8	451	Q9Y2G2
RQLFIEMRAQNFDVI	DTNB	16	O60941
FNDCRDIIQRMHLRQ	GNAS	376	P63092
DKVNFFQRELRQVHM	AREL1	441	O15033
AMRQVLAARAIHNIF	APPL2	516	Q8NEU8
LYEQRFAELMRLNHN	MARCHF10	756	Q8NA82
NQNFMLIITHREVQR	FAF1	191	Q9UNN5
RFLRVHQSNIFMVTE	C1orf127	126	Q8N9H9
FLNRILGMEVHQQNA	SBNO1	1106	A3KN83
LHEMLQQIFSLFRAN	IFNE	81	Q86WN2
QRRRLYNANIMDHIA	OTOF	721	Q9HC10
DLRNRRFEQAQHMFR	PARD3	331	Q8TEW0
VVILFHMFLDRAQRA	RTP1	106	P59025
GILRVFEMFQHNQLN	SNX13	901	Q9Y5W8
FQHRENRLAERMAIL	SFI1	531	A8K8P3
RFLNRAAVAFQNLFM	SPRING1	146	Q9H741
RIHALRQMNENFPEN	STARD13	706	Q9Y3M8
RSHQFRMLVVSNFQE	UVSSA	71	Q2YD98
RLLNEVMVEHFFRQG	RMND5A	116	Q9H871
HFQVRVKVFEARQLM	FER1L5	166	A0AVI2
RRANMHIRDFLQVFI	TAF1L	816	Q8IZX4
LEERMQRFAQQHQAR	NDUFV1	446	P49821
LNNFHNRMQSTDIIR	FASTKD2	61	Q9NYY8
ALQAEMNHFHQRREL	SNX33	526	Q8WV41
RMNVDQAFHELVRVI	RRAS2	161	P62070
FRQFILVMNALDNRA	UBA2	106	Q9UBT2
LVMNALDNRAARNHV	UBA2	111	Q9UBT2
IDQRLHIQMYFFLRN	OR6T1	51	Q8NGN1
VMALDYLQNQRIIHR	STK32A	131	Q8WU08
GFVQDMRLIFQNHRA	SP140L	531	Q9H930
AFMNQAFLQSHIQRR	DZIP1	206	Q86YF9
MFHLRRSSFLQVFNN	SEC23A	581	Q15436
DRLNRMNQAAKHFLL	CLCA4	321	Q14CN2
DFLNLRRMLVQTHLQ	SEPTIN1	266	Q8WYJ6
IRQVHNSFARQQMFE	UCHL5	136	Q9Y5K5
ARAVRNVRNVMYLHQ	SPRYD3	356	Q8NCJ5
VNNFRMIERHYFRNQ	UNC119	156	Q13432
VNHRQRSLALGIQFM	SLCO4C1	606	Q6ZQN7
IFRNHMSDFRIQKQQ	SPATA24	161	Q86W54
KRFMQLISLQFHQRT	ZSCAN5A	391	Q9BUG6
KAFAQRMDLARHQQI	ZNF840P	556	A6NDX5
NQRQAHVDFEAMLRQ	YJU2	161	Q9BW85
RMRFHKLQNVQIALD	PLEC	231	Q15149
LFFNMNNRQHVDQRR	SNX10	81	Q9Y5X0
VMLENFRNLLLVAHQ	ZNF112	36	Q9UJU3
AFIQMSNLVRHQRIH	ZNF569	446	Q5MCW4
QLREHQENSLRFMVL	ZNF544	131	Q6NX49
RNVFRELQIMQGLEH	STK32B	66	Q9NY57
IMVLNRQFEHVQNFI	TRIM66	191	O15016
AQEFFLHLINMVERN	USP5	436	P45974
RISNFHYLMQLNRLA	WDR81	356	Q562E7
VHLAIRFQRQDMLAI	ZRANB1	316	Q9UGI0
REVQMNVLAFNRQFH	ATP6V0D2	296	Q8N8Y2
MSRLQFLFVQHNLIE	ELFN2	126	Q5R3F8
MHRNVRYNCRVIFLN	NADSYN1	91	Q6IA69