Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase binding

PCF11 PABPN1 CCAR2 PKN2 MYZAP SPTY2D1

2.52e-0765816GO:0070063
GeneOntologyMolecularFunctionRNA polymerase core enzyme binding

PCF11 CCAR2 MYZAP SPTY2D1

3.30e-0545814GO:0043175
GeneOntologyMolecularFunctioncadherin binding

MMP24 TMPO MACF1 PKN2 CTNNA1 PAK6 CDH9 PPL

6.96e-05339818GO:0045296
GeneOntologyMolecularFunctionRNA polymerase II complex binding

PCF11 CCAR2 MYZAP

5.29e-0439813GO:0000993
GeneOntologyMolecularFunctionprotein serine kinase activity

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

6.79e-04363817GO:0106310
GeneOntologyMolecularFunctioncell adhesion molecule binding

MMP24 DST TMPO MACF1 PKN2 CTNNA1 PAK6 CDH9 PPL

7.07e-04599819GO:0050839
GeneOntologyMolecularFunctionhistone binding

PHC3 NCAPD3 USP51 MSL3 CBX7 SPTY2D1

7.29e-04265816GO:0042393
DomainPlectin_repeat

DST MACF1 PPL

2.62e-067803IPR001101
DomainPlectin

DST MACF1 PPL

2.62e-067803PF00681
DomainPLEC

DST MACF1 PPL

2.62e-067803SM00250
DomainSpectrin_repeat

DST MACF1 PPL

2.55e-0429803IPR002017
Domain-

DST MACF1

2.69e-0468023.90.1290.10
DomainGAR

DST MACF1

2.69e-046802PS51460
Domain-

DST MACF1

2.69e-0468023.30.920.20
DomainGAS_dom

DST MACF1

2.69e-046802IPR003108
DomainGAS2

DST MACF1

2.69e-046802PF02187
DomainGAS2

DST MACF1

2.69e-046802SM00243
DomainSpectrin/alpha-actinin

DST MACF1 PPL

3.43e-0432803IPR018159
DomainSPEC

DST MACF1 PPL

3.43e-0432803SM00150
DomainArm_3

KPNA6 KPNA1

3.75e-047802PF16186
DomainImporting_su_alpha

KPNA6 KPNA1

3.75e-047802IPR024931
DomainArm_3

KPNA6 KPNA1

3.75e-047802IPR032413
DomainIBB

KPNA6 KPNA1

3.75e-047802PF01749
DomainIBB

KPNA6 KPNA1

4.99e-048802PS51214
Domain-

BAZ2B MBD4

4.99e-0488023.30.890.10
DomainKinase-like_dom

TTBK1 DST MACF1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

5.08e-04542809IPR011009
DomainImportin-a_IBB

KPNA6 KPNA1

6.40e-049802IPR002652
DomainSer/Thr_kinase_AS

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

8.44e-04357807IPR008271
DomainS_TKc

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

8.72e-04359807SM00220
DomainPROTEIN_KINASE_ST

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

9.16e-04362807PS00108
DomainMethyl_CpG_DNA-bd

BAZ2B MBD4

9.72e-0411802IPR001739
DomainMBD

BAZ2B MBD4

9.72e-0411802PF01429
DomainDNA-bd_dom

BAZ2B MBD4

9.72e-0411802IPR016177
DomainMBD

BAZ2B MBD4

9.72e-0411802SM00391
DomainMBD

BAZ2B MBD4

9.72e-0411802PS50982
DomainPkinase

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

1.23e-03381807PF00069
DomainuDENN

DENND2C DENND2B

1.59e-0314802SM00800
DomainuDENN

DENND2C DENND2B

1.83e-0315802PF03456
DomainUDENN

DENND2C DENND2B

2.09e-0316802PS50946
DomainDDENN

DENND2C DENND2B

2.09e-0316802PS50947
DomainDENN

DENND2C DENND2B

2.09e-0316802SM00799
DomaindDENN

DENND2C DENND2B

2.09e-0316802SM00801
DomainDENN

DENND2C DENND2B

2.09e-0316802PF02141
DomaindDENN_dom

DENND2C DENND2B

2.09e-0316802IPR005112
DomainuDENN_dom

DENND2C DENND2B

2.09e-0316802IPR005113
DomaindDENN

DENND2C DENND2B

2.09e-0316802PF03455
DomainDENN

DENND2C DENND2B

2.09e-0316802PS50211
DomainDENN_dom

DENND2C DENND2B

2.09e-0316802IPR001194
DomainPBD

PAK6 CDC42BPB

2.09e-0316802SM00285
DomainPBD

PAK6 CDC42BPB

2.36e-0317802PF00786
DomainCRIB

PAK6 CDC42BPB

3.27e-0320802PS50108
DomainPROTEIN_KINASE_ATP

TTBK1 PKN2 MAPK4 PAK6 CDC42BPB NEK9 EIF2AK3

3.51e-03459807PS00107
DomainCRIB_dom

PAK6 CDC42BPB

3.61e-0321802IPR000095
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PCF11 ELOA PHC3 NCAPD3 KIF23 PHF3 MSL3 MKI67 TRAPPC10 TMPO BUD13 CCAR2 PKN2 CTNNA1 RERE PPL

3.31e-11774821615302935
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

PCF11 KIF23 NUP107 ATAD3A MSL3 MKI67 CTNNBL1 DDX23 TMPO BUD13 CCAR2 KPNA6 CEP192 CTNNA1 VPS28 NEK9 PPL KPNA1

1.66e-101155821820360068
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PCF11 ELOA SNX4 PTPRA NUP107 MKI67 LRP6 TMPO CCAR2 SDF4 KPNA6 CEP192 CTNNA1 CCDC77 STX17 CDC42BPB KPNA1

3.20e-101049821727880917
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

TAF6L PHC3 NCAPD3 KIF23 DST NUP107 NOP16 PABPN1 ATAD3A BAZ2B PHF3 MSL3 MKI67 DDX23 TMPO MBD4 SPTY2D1

7.45e-091294821730804502
Pubmed

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

DST LRP6 MACF1 AXIN1

9.35e-091182416815997
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RAB3GAP1 KIF23 DST NUP107 PABPN1 ATAD3A MKI67 CTNNBL1 DDX23 CASP8 MACF1 OAS3 CCAR2 PKN2 NEK9 KPNA1

9.34e-081353821629467282
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

PCF11 ELOA PHC3 NOP16 PABPN1 PHF3 MKI67 CTNNBL1 DDX23 TMPO OAS3 SDF4 CCDC77 ALKBH5 CDC42BPB SPTY2D1

1.12e-071371821636244648
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PCF11 RAB3GAP1 TTBK1 ATAD3A BAZ2B TMEM132A MACF1 PLEKHA6 CDC42BPB NEK9

2.57e-07493821015368895
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PCF11 ELOA PHC3 KIF23 NOP16 ATAD3A BAZ2B PHF3 MKI67 TMPO CASP8 BUD13 MBD4

3.56e-07954821336373674
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

KIF23 DST NUP107 ATAD3A MKI67 CTNNBL1 DDX23 TMPO MACF1 KPNA6 KPNA1

4.37e-07660821132780723
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

ELOA SNX4 PABPN1 ATAD3A TMPO CASP8 UBA3 KPNA6 CCDC77 ALKBH5 KPNA1

8.23e-07704821132994395
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

KIF23 CCDC9B DST ATAD3A MKI67 MACF1 KPNA6 KPNA1

8.26e-0731582826777405
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

KIF23 CCDC9B NUP107 NOP16 ATAD3A PHF3 WDR87 MKI67 TRAPPC10 TMPO BUD13 CTNNA1 PLEKHA6 AXIN1

1.22e-061247821427684187
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

NCAPD3 KIF23 NUP107 PHF3 CTNNBL1 TMPO CCAR2 PKN2

1.22e-0633282832786267
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

NCAPD3 RAB3GAP1 KIF23 DST NOP16 ATAD3A MKI67 TRAPPC10 DDX23 TMPO OAS3 CCAR2 SDF4 CTNNA1 STX17

1.23e-061440821530833792
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

ELOA KIF23 CCDC9B DST NOP16 ATAD3A PHF3 MKI67 TMPO BUD13 OAS3 CTNNA1 PPL KPNA1

1.34e-061257821436526897
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

ELOA NCAPD3 KIF23 PABPN1 PHF3 MKI67 TMPO BUD13 MACF1 CCAR2 SPTY2D1

1.71e-06759821135915203
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

PCF11 RAB3GAP1 NUP107 ATAD3A DDX23 TMPO MACF1 SDF4 PKN2 CEP192 CTNNA1 CCDC77 CDC42BPB EIF2AK3 PREPL

1.83e-061487821533957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PCF11 TAF6L PHC3 NCAPD3 DST NOP16 PHF3 CTNNBL1 BUD13 MACF1 MBD4 ALKBH5 CDC42BPB SPTY2D1 KPNA1

1.98e-061497821531527615
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

PCF11 KIF23 DST NUP107 MKI67 TMPO CCAR2 CEP192 CDC42BPB SPTY2D1 PPL

2.14e-06777821135844135
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ELOA DST NUP107 TMPO MACF1 CTNNA1 CDC42BPB PPL

2.23e-0636082833111431
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

DST PABPN1 ATAD3A PHF3 MKI67 DDX23 TMPO KPNA6 NEK9

3.11e-0650682930890647
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

KIF23 DST NUP107 ATAD3A PHF3 MKI67 DDX23 MACF1 CCAR2 CTNNA1

3.23e-06653821022586326
Pubmed

PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress.

ATAD3A EIF2AK3

5.49e-06282239116259
Pubmed

Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.

DST MACF1

5.49e-06282211002341
Pubmed

Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction.

LRP6 AXIN1

5.49e-06282223892894
Pubmed

Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis.

KPNA6 KPNA1

5.49e-06282222156475
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

TAF6L RAB3GAP1 HSP90B2P NUP107 CTNNBL1 PKN2 CTNNA1

5.55e-0628882723383273
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

TAF6L DST ATAD3A MKI67 CTNNBL1 OAS3 SPTY2D1 KPNA1

5.80e-0641082826949251
Pubmed

Human transcription factor protein interaction networks.

PCF11 TAF6L PHC3 KIF23 DST NUP107 NOP16 PABPN1 ATAD3A MKI67 LRP6 CCAR2 CEP192 RERE

5.89e-061429821435140242
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

KIF23 TTBK1 ATAD3A DDX23 CCAR2 UBA3 KPNA6 ODAD4 PAK6 CDC42BPB NEK9 AXIN1 KPNA1

9.32e-061284821317353931
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

PCF11 NUP107 PABPN1 DDX23 TMPO MACF1 PKN2 CTNNA1 KPNA1

9.58e-0658282920467437
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PCF11 KIF23 NUP107 PHF3 MKI67 KPNA6 EIF2AK3 KPNA1

9.69e-0644082834244565
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

PHC3 NCAPD3 KIF23 NUP107 MKI67 PPL

1.08e-0521082616565220
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ELOA PHC3 KIF23 BAZ2B PHF3 MKI67 TMPO MBD4 KPNA1

1.36e-0560882936089195
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

ELOA NCAPD3 KIF23 BAZ2B CCDC77 SPTY2D1

1.48e-0522282637071664
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

NUP107 NOP16 ATAD3A BAZ2B PHF3 MKI67 TMPO

1.63e-0534082729478914
Pubmed

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α.

CTNNBL1 KPNA1

1.64e-05382224269683
Pubmed

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus.

KPNA6 KPNA1

1.64e-05382221245837
Pubmed

Expression of the mouse Macf2 gene during inner ear development.

DST MACF1

1.64e-05382212399109
Pubmed

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

LRP6 AXIN1

1.64e-05382217569865
Pubmed

[Identification of prototype foamy virus Bel1 nuclear localization signal and its corresponding importins].

KPNA6 KPNA1

1.64e-05382225272585
Pubmed

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.

HSP90B2P LRP6

1.64e-05382223572575
Pubmed

Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.

KPNA6 KPNA1

1.64e-05382218716025
Pubmed

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.

LRP6 AXIN1

1.64e-05382212897152
Pubmed

A protein interaction landscape of breast cancer.

DST MKI67 CASP8 MACF1 SDF4 KPNA6 CTNNA1 MBD4 KPNA1

1.89e-0563482934591612
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

ELOA KIF23 NOP16 PABPN1 PHF3 MKI67 CTNNBL1 DDX23 TMPO CCAR2 SPTY2D1

2.06e-05989821136424410
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

DST NUP107 CTNNBL1 TMPO MACF1 CTNNA1 CDC42BPB KPNA1

2.36e-0549882836634849
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

PTPRA DST TMPO PKN2 CTNNA1 CDC42BPB ATP2B3

3.15e-0537782738117590
Pubmed

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.

KPNA6 KPNA1

3.28e-05482232792398
Pubmed

Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.

PHC3 CBX7

3.28e-05482226343356
Pubmed

Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.

DST MACF1

3.28e-0548228954775
Pubmed

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

LRP6 AXIN1

3.28e-05482218077588
Pubmed

Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.

KPNA6 KPNA1

3.28e-05482225599645
Pubmed

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.

MYZAP CDC42BPB

3.28e-05482221240187
Pubmed

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.

KPNA6 KPNA1

3.28e-05482216298512
Pubmed

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.

LRP6 AXIN1

3.28e-05482218762581
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

TAF6L NCAPD3 NUP107 PABPN1 ATAD3A DDX23 TMPO CCAR2 SDF4 KPNA6 NEK9 KPNA1

3.78e-051257821237317656
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

NUP107 MKI67 MACF1 CCDC77 ATP2B3 AXIN1

3.82e-0526382634702444
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PCF11 ELOA DST PABPN1 ATAD3A CTNNBL1 DDX23 TMPO BUD13 MACF1 CATSPERG

4.67e-051082821138697112
Pubmed

ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m6A-YTHDF1-dependent manner.

ALKBH5 EIF2AK3

5.47e-05582238056583
Pubmed

Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.

KPNA6 KPNA1

5.47e-05582230540948
Pubmed

Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.

MKI67 MAPK4

5.47e-05582219805361
Pubmed

Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression.

KPNA6 KPNA1

5.47e-0558229369227
Pubmed

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

LRP6 AXIN1

5.47e-05582219107203
Pubmed

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.

KIF23 CTNNA1

5.47e-05582222750944
Pubmed

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.

CASP8 EIF2AK3

5.47e-05582218787411
Pubmed

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.

KPNA6 KPNA1

5.47e-05582217981117
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

PHF3 CTNNBL1 MACF1 PKN2 ALKBH5 KPNA1

5.52e-0528182624163370
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

TAF6L PHC3 BAZ2B MSL3 MACF1 CCAR2

5.63e-0528282623667531
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

DST TMPO MACF1 PKN2 CTNNA1 PLEKHA6 PAK6 PPL

5.73e-0556582825468996
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

PCF11 ELOA PHF3 MKI67 TMPO ALKBH5

5.74e-0528382630585729
Pubmed

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

BAZ2B CTNNA1 ZNF844

5.96e-053282326142281
Pubmed

The functional interactome landscape of the human histone deacetylase family.

MKI67 TMPO CCAR2 KPNA6 RERE KPNA1

6.45e-0528982623752268
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ELOA PHC3 KIF23 DST NUP107 MKI67 TMPO MACF1 PKN2 NEK9

6.93e-05934821033916271
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NCAPD3 NAT14 RAB3GAP1 SNX4 NUP107 ATAD3A LRP6 TMPO KPNA6 CTNNA1

7.44e-05942821031073040
Pubmed

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

KPNA6 KPNA1

8.19e-0568228551560
Pubmed

IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation.

KPNA6 KPNA1

8.19e-05682226060253
Pubmed

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.

KPNA6 KPNA1

8.19e-0568227859280
Pubmed

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.

KPNA6 KPNA1

8.19e-0568228529100
Pubmed

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.

LRP6 AXIN1

8.19e-05682219075000
Pubmed

Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.

KPNA6 KPNA1

8.19e-0568229008157
Pubmed

p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.

KPNA6 KPNA1

8.19e-0568222064827
Pubmed

A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal.

KPNA6 KPNA1

8.19e-05682215037073
Pubmed

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

KPNA6 KPNA1

8.19e-0568228876228
Pubmed

Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.

KPNA6 KPNA1

8.19e-0568227745752
Pubmed

Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.

KPNA6 KPNA1

8.19e-0568229548947
Pubmed

Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion.

KPNA6 KPNA1

8.19e-0568228659115
Pubmed

The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells.

KPNA6 KPNA1

8.19e-0568229557700
Pubmed

A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells.

KPNA6 KPNA1

8.19e-0568229603322
Pubmed

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells.

KPNA6 KPNA1

8.19e-0568229593140
Pubmed

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.

KPNA6 KPNA1

8.19e-0568227585960
Pubmed

Three distinct classes of the alpha-subunit of the nuclear pore-targeting complex (importin-alpha) are differentially expressed in adult mouse tissues.

KPNA6 KPNA1

8.19e-05682210026238
Pubmed

Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.

SLC8A1 ATP2B3

8.19e-05682212767889
Pubmed

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

KPNA6 KPNA1

8.19e-0568228041786
Pubmed

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

KPNA6 KPNA1

8.19e-0568228041734
Pubmed

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.

KPNA6 KPNA1

8.19e-0568229303297
Pubmed

Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence.

KPNA6 KPNA1

8.19e-05682211904219
Pubmed

Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages.

KPNA6 KPNA1

8.19e-0568229918876
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ELOA ATAD3A MKI67 DDX23 TMPO CCAR2 KPNA6 KPNA1

9.22e-0560582828977666
InteractionLYAR interactions

ELOA KIF23 NOP16 MKI67 DDX23 BUD13 OAS3 KPNA6 KPNA1

2.06e-05373829int:LYAR
InteractionOGT interactions

ELOA PHC3 SNX4 PABPN1 ATAD3A MKI67 TMPO CASP8 HCFC1R1 UBA3 KPNA6 CCDC77 ALKBH5 KPNA1

2.68e-059508214int:OGT
InteractionDCPS interactions

NUP107 NOP16 ATAD3A BAZ2B PHF3 MKI67 TMPO UBA3 KPNA6

3.17e-05394829int:DCPS
InteractionTADA2B interactions

TAF6L KIF23 USP51 KPNA6 KPNA1

3.30e-0590825int:TADA2B
CytobandEnsembl 112 genes in cytogenetic band chr3q21

SNX4 MBD4 KPNA1 PARP15

2.01e-04160824chr3q21
GeneFamilyEF-hand domain containing|Plakins

DST MACF1 PPL

1.40e-068543939
GeneFamilyZinc fingers CXXC-type|Methyl-CpG binding domain containing

BAZ2B MBD4

4.73e-04115421025
GeneFamilyArmadillo repeat containing|Importins

KPNA6 KPNA1

1.30e-0318542596
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND2C DENND2B

2.51e-0325542504
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NCAPD3 KIF23 NUP107 TMPO CEP192 CCDC77

1.41e-06190826d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NCAPD3 KIF23 NUP107 MKI67 CEP192 CCDC77

1.54e-061938264b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 MKI67 TMPO OAS3 CEP192

7.50e-0614682545d7cb73776e60d22f335a651845e21e16948fcc
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO CCDC77

1.66e-05172825c06ca5d075937747952ed915c9db39a9f62072f9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 KIF23 MKI67 PAK6 CCDC77

2.17e-05182825336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast|bone_marrow / Manually curated celltypes from each tissue

MMP24 NAT14 NOP16 DENND2C ALKAL2

2.29e-05184825030d5ef5e44e4d973862128fe01f7e8ef0092a06
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

MKI67 OAS3 CTNNA1 PLEKHA6 PPL

2.29e-051848252e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A3 SNX4 DST MACF1 PDE5A

2.67e-05190825d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

COL6A3 DST MACF1 PDE5A PKN2

2.67e-0519082571e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA BAZ2B PHF3 MSL3 PKN2

2.74e-0519182560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellEndothelial-D_(cycle)|World / shred on cell class and cell subclass (v4)

NCAPD3 KIF23 MKI67 TMPO MYZAP

2.74e-0519182549a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA BAZ2B PHF3 MSL3 PKN2

2.74e-0519182509db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA BAZ2B PHF3 MSL3 PKN2

2.74e-05191825973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF23 DENND2C TMEM132A MKI67 MYZAP

2.81e-05192825a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCellILEUM-inflamed-(8)_Smooth_muscle_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

COL6A3 DST PDE5A ALKAL2 DENND2B

2.88e-05193825084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 DST MACF1 PDE5A RERE

3.02e-051958253e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 MKI67 TMPO CCDC77

3.02e-05195825b57132802cb977551e214880984f3edcd375474f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO MYZAP

3.18e-05197825a41420d4b6d502c2f594c054c7efbb5d4eac83ff
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO MYZAP

3.18e-051978251c89d6836eed30c50c765f7dde9cc8ee15c363d2
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHC3 PHF3 CASP8 MACF1 PARP15

3.33e-05199825f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

COL6A3 KIF23 DST MKI67 MACF1

3.33e-051998257ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DST DENND2C CTNNA1 DENND2B PPL

3.41e-0520082597f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF3 CASP8 MACF1 OAS3 PKN2

3.41e-0520082512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

MMP24 CCDC9B DENND2C LRP6

1.49e-0414582480684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

MMP24 CCDC9B DENND2C LRP6

1.49e-04145824cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC8A1 DST TMEM132A OAS3

2.02e-04157824e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLC8A1 DST TMEM132A OAS3

2.07e-04158824e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCellPND01-03-samps|World / Age Group, Lineage, Cell class and subclass

CCDC9B DENND2C MYZAP ALKBH5

2.22e-041618241973b112d8d67aacc02751797d0148e7b53bfa66
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 CLHC1

2.39e-04164824249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF23 MKI67 CEP192 CCDC77

2.44e-0416582496f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 MKI67 CEP192 PAK6

2.56e-04167824a90f905ef38437752e2b0b71bd0322a184de1861
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 WDR87 MKI67 TMPO

2.67e-04169824563c267edaade0e5df192ad953801ef9768d4270
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCAPD3 ATAD3A BUD13 CCAR2

2.74e-0417082412aa9bdb18f3bf6da2a25984d08fe9497e5570ed
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 DST MACF1 PDE5A

3.05e-041758241799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 CCDC77

3.05e-04175824a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 MKI67 TMPO PDE5A

3.05e-041758243e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T|Lung / Manually curated celltypes from each tissue

NCAPD3 KIF23 MKI67 TMPO

3.12e-04176824a40dfd8c4ba16757ff929b2f03a0628acf334de4
ToppCell(01)_Cycling_Basal_(homeostasis)|World / shred by cell type and Timepoint

KIF23 MKI67 TMPO CCDC77

3.19e-0417782405c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO

3.33e-0417982454191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RAB3GAP1 CCDC9B CCDC77 PARP15

3.33e-041798245be883d7d0be3180bb9844e4a757f0dd247294e4
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 USP51 NUP107

3.47e-04181824b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 USP51 NUP107

3.47e-04181824c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC8A1 USP51 CCAR2 MYZAP

3.54e-04182824d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

DST BAZ2B OAS3 PKN2

3.62e-041838248f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCAR2 SDF4 PAK6 CDH9

3.77e-041858244e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DENND2C PDE5A ALKAL2 MYZAP

3.77e-04185824709236097cbfc254796fcc69b5f5178b73dad9bd
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DENND2C PDE5A ALKAL2 MYZAP

3.77e-04185824af078a6c4a3e0b54b7d8ab7b30dcd06053ebfd28
ToppCellCOVID_vent-Myeloid-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

SLC8A1 DST CTNNA1 PLEKHA6

3.85e-0418682463a5cdd3f60681762a218be32db84be8f29b88fd
ToppCellCOVID_vent-Myeloid-Dendritic-cDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

SLC8A1 DST CTNNA1 PLEKHA6

3.85e-0418682439457a7b43537f2c3e221f9375c95d4515424d7d
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCAR2 SDF4 PAK6 CDH9

3.85e-0418682416092819e9148dfe64f07c737652b6e533e699f7
ToppCellDividing_Macrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NCAPD3 KIF23 MKI67 TMPO

3.85e-041868240067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 MKI67 PAK6 CCDC77

3.92e-04187824057569c9437219ecc396aa6e673b1178a2273837
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 MKI67 TMPO PDE5A

4.00e-0418882495d0a796d62ce6d121e2028c378faffc14b35275
ToppCellMatrixFB-Fibroblast-E_(Early_Fibroblastic_progenitor)|MatrixFB / shred on cell class and cell subclass (v4)

NCAPD3 KIF23 MKI67 TMPO

4.00e-04188824b240ea20750ffb825cb5fe41d06c632233406ab6
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NCAPD3 KIF23 MKI67 TMPO

4.09e-041898241e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

DENND2C MAPK4 MBD4 EIF2AK3

4.17e-041908243729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 SLC8A1 KCNH1 MAPK4

4.17e-04190824562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 MKI67 TMPO

4.17e-041908244288189e3a499c395896c950598810b02f401685
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 SLC8A1 KCNH1 MAPK4

4.17e-04190824f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCelldroplet-Marrow-BM-30m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 MKI67 TMPO

4.25e-0419182408be56a4055a73c920d345fd3b2052a5ccb675d8
ToppCellE17.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF23 MKI67 TMPO MYZAP

4.25e-04191824efe0cb0b6602621f5eda72a723b83b38bf15607f
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCAPD3 KIF23 MKI67 TMPO

4.25e-04191824bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellEndothelial-Endothelial-D_(cycle)|Endothelial / shred on cell class and cell subclass (v4)

NCAPD3 KIF23 MKI67 TMPO

4.25e-04191824a3c5a913a99f17633c140ec9ece81b73e59e0715
ToppCellE17.5-Endothelial-proliferative_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF23 MKI67 TMPO MYZAP

4.25e-0419182400676c598f6dae0ff9158d064248f1265432f3e1
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF23 MKI67 TMPO PDE5A

4.25e-04191824f764cc21fef87ebad765011098f647ae1bdf6158
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCAPD3 KIF23 MKI67 TMPO

4.34e-0419282452d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 DST MACF1 PDE5A

4.34e-0419282499ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 PTPRA DST MACF1

4.42e-0419382406b65110db974f4ef90d3511ff34428976a52c9c
ToppCellP07-Endothelial-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NCAPD3 KIF23 MKI67 TMPO

4.42e-041938241e95ef29357969ee385b4717c0b5a497390ac260
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 PTPRA DST MACF1

4.42e-041938249c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIF23 MKI67 TMPO PDE5A

4.42e-04193824a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 PTPRA DST MACF1

4.42e-04193824a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL6A3 DST MACF1 PDE5A

4.42e-0419382499525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL6A3 DST MACF1 PDE5A

4.42e-04193824b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCelldroplet-Tongue-nan-24m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 KIF23 MKI67 TMPO

4.42e-04193824f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCellP07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NCAPD3 KIF23 MKI67 TMPO

4.42e-041938240f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 PTPRA DST MACF1

4.42e-04193824b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellP03-Endothelial-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NCAPD3 KIF23 MKI67 TMPO

4.51e-0419482422bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCellP03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NCAPD3 KIF23 MKI67 TMPO

4.51e-041948245e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 DST MACF1 RERE

4.51e-04194824b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell(1)_T_cells_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NCAPD3 KIF23 MKI67 TMPO

4.51e-041948248f313071933451780309d2174ed27d8cdc734343
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 DST PDE5A DENND2B

4.51e-0419482490efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 DST PDE5A DENND2B

4.51e-04194824df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KIF23 MKI67 TMPO PDE5A

4.51e-04194824d840c1949c328779426c9172e02da09e968f0567
ToppCelldroplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF23 DST PAK6 MYZAP

4.51e-0419482437803f4abf1aa1ad771c9cd293933003d7101e70
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 MYZAP

4.51e-041948243a49c7c86036e09a8cd0114988380d04ad1a26fb
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|367C / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 KIF23 MKI67 TMPO

4.51e-04194824a12b64945e10f00aa983678a02586c59badc1570
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL6A3 DST MACF1 PKN2

4.60e-041958241cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL6A3 DST MACF1 RERE

4.60e-041958240e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

NCAPD3 KIF23 MKI67 TMPO

4.60e-04195824764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell(1)_T_cells-(1)_T_cells_Dividing|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

NCAPD3 KIF23 MKI67 TMPO

4.60e-04195824cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 MYZAP

4.60e-041958245790b47b0e028e49b99bda8d6d9e80ac79208cdf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PHF3 NEK9 PREPL PARP15

4.60e-04195824ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 DST MACF1 RERE

4.60e-041958247796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRA MACF1 PDE5A ALKBH5

4.69e-0419682444f5b1b474399c9316729155f2ea95a82ca66e30
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 KIF23 MKI67 TMPO

4.69e-041968249591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO

4.69e-0419682420383d576708b7e4bfce3e9fe40548cce496e3cb
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 DST MACF1 PDE5A

4.69e-041968249737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 DST MACF1 PKN2

4.69e-041968241450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 KIF23 MKI67 TMPO

4.69e-041968240644bd14a944b9c9759a295dfdd5e67a4775f20a
ComputationalNuclear pore complex.

NUP107 TMPO KPNA1

5.79e-0517493MODULE_352
Drugresveratrol; Down 200; 10uM; MCF7; HT_HG-U133A_EA

PCF11 ELOA KIF23 PABPN1 MKI67 TMPO KPNA1

3.42e-06176827958_DN
DrugAmoxicillin [26787-78-0]; Down 200; 11uM; PC3; HT_HG-U133A

PABPN1 PHF3 TMEM132A HCFC1R1 OAS3 NEK9 DENND2B

6.71e-061958276285_DN
Drug5252917; Down 200; 14uM; MCF7; HT_HG-U133A_EA

TAF6L ELOA TMEM132A TRAPPC10 HCFC1R1 MACF1 KPNA6

6.71e-06195827944_DN
DrugBenzonatate [104-31-4]; Down 200; 6.6uM; PC3; HT_HG-U133A

PHF3 TMEM132A CBX7 LRP6 HCFC1R1 PLEKHA6 STX17

7.17e-061978271801_DN
DrugMega 8

MECR KCNH1 PPL

1.25e-0513823CID000160091
DiseaseHEPATOCELLULAR CARCINOMA

CASP8 AXIN1

2.58e-049802114550
DiseaseAdult Hepatocellular Carcinoma

CASP8 AXIN1

2.58e-049802C0279607
DiseaseHepatocellular carcinoma

CASP8 AXIN1

2.58e-049802cv:C2239176
DiseasePetit mal status

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0270823
DiseaseGrand Mal Status Epilepticus

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0311335
DiseaseStatus Epilepticus, Subclinical

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0751522
DiseaseSimple Partial Status Epilepticus

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0751524
DiseaseNon-Convulsive Status Epilepticus

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0751523
DiseaseComplex Partial Status Epilepticus

SLC8A1 CASP8 EIF2AK3

8.11e-0467803C0393734
Diseasecancer (implicated_via_orthology)

PHC3 DST CBX7 MACF1 AXIN1

8.22e-04268805DOID:162 (implicated_via_orthology)
DiseaseStatus Epilepticus

SLC8A1 CASP8 EIF2AK3

8.47e-0468803C0038220
Diseaseobsolete aging

COL6A3 BAZ2B RERE ALKAL2 AXIN1

9.83e-04279805GO_0007568
DiseaseTourette syndrome, schizophrenia

PHF3 RERE

1.08e-0318802EFO_0004895, MONDO_0005090
DiseaseMyocardial Ischemia

SLC8A1 PTPRA TMPO EIF2AK3

1.36e-03176804C0151744
Diseasekidney disease (biomarker_via_orthology)

MKI67 CASP8

1.47e-0321802DOID:557 (biomarker_via_orthology)
Diseasefemoral neck bone mineral density

KCNH1 BUD13 RERE AXIN1

2.01e-03196804EFO_0007785
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

RAB3GAP1 BUD13 SPTY2D1

2.50e-0399803EFO_0004611, EFO_0007878

Protein segments in the cluster

PeptideGeneStartEntry
DRRPKERISFEVMVL

CCAR2

526

Q8N163
RMTEDRAEPKEAVER

CATSPERG

1141

Q6ZRH7
LDRMLREQEREGDPM

BUD13

531

Q9BRD0
DEDAEPRRSRRKLMV

SDF4

91

Q9BRK5
KRPRDDEEEEQKMRR

CTNNBL1

16

Q8WYA6
LPNRELAREKVMREV

EIF2AK3

626

Q9NZJ5
EEDVIPRIRAMEGRR

BAZ2B

831

Q9UIF8
RPRILEMDKEENRRS

ALKBH5

336

Q6P6C2
FDLPGQEERERLVRM

ATAD3A

521

Q9NVI7
RIREEEGMRREIFKD

CCDC77

376

Q9BR77
NEVLELRRPMDSRLE

DENND2B

856

P78524
GFRPRDRDDMVRKII

ATP2B3

621

Q16720
EEELKRMGSPEERRQ

RAB3GAP1

911

Q15042
QKMPLDDLDREDEVR

NUP107

331

P57740
RRKERRLPQDDVDIM

MMP24

576

Q9Y5R2
PLIRDMLRRIKEDED

HSP90B2P

331

Q58FF3
ALNPEEMRRRREEEG

KPNA6

21

O60684
PMLQKELDDRRRETE

PARP15

131

Q460N3
LRDFLERMLVRDPQE

PAK6

631

Q9NQU5
RRREMEEKVTLLNAP

NEK9

311

Q8TD19
PVIREEDKDELLRVM

MAPK4

246

P31152
EREKALRPEVERLEM

DST

371

Q03001
MKETLRIRRLGEPED

DHRS4L1

236

P0CG22
PMSRQEKDAELDRRI

CCDC9B

56

Q6ZUT6
LSVREMREDEKPLVL

NAT14

6

Q8WUY8
ERKRREEQMPREGDS

OPTC

26

Q9UBM4
DPEMEKELQRLREEI

PPL

1241

O60437
DRERKELNIEPTDLM

PDE5A

791

O76074
KEEPELQTRREMEER

MSL3

156

Q8N5Y2
EEEERMKRKNEAPLI

KCNH1

716

O95259
MRKILISEDLEEPRA

LRP6

436

O75581
EERRVERDILKEMFP

TMPO

336

P42167
QRREGEMKEIERPFE

MKI67

916

P46013
PEEERLQQRREMLRD

CDC42BPB

1561

Q9Y5S2
LGRKMLEDPQERERR

DDX23

201

Q9BUQ8
ERELRDVRIRKMPEN

PHC3

891

Q8NDX5
EMLEREKSLRPAVER

MACF1

411

Q9UPN3
DIRDPRRMKKTEEER

PCF11

551

O94913
DPELEAIKARVREME

PABPN1

116

Q86U42
RKAVLMIRTPEELDD

CTNNA1

626

P35221
RKRPRDALQKEEEME

ELOA

121

Q14241
VEFEMPRDRRRLEQE

GJA9

121

P57773
ERLKRVRMEEEGEDG

AXIN1

411

O15169
VREFRELPNIEERIM

COL6A3

1596

P12111
DPDEMRMQALLIRER

FEM1A

366

Q9BSK4
PRLVMAYEEKEERDR

CBX7

51

O95931
ILDEVEKRREMSPAL

DENND2C

606

Q68D51
TRKEEMERELQTPGR

CASP8

81

Q14790
PNDLRKEDVAMELER

MBD4

31

O95243
ALEERAMEKLREKVP

CEP192

1081

Q8TEP8
ERTAPRRVRTEEEML

CDC20B

6

Q86Y33
MSTKRRLEEEQEPLR

HCFC1R1

41

Q9NWW0
VITEEELRRPEMKNF

MECR

236

Q9BV79
EAREDSKLRRDVMPE

CDH9

681

Q9ULB4
LPVDKLEEEINRRMA

PTPRA

221

P18433
EVDALLERQKREAMP

KIF23

166

Q02241
PRRAEILDEMRAQLE

OAS3

491

Q9Y6K5
MSEREERRFVEIPRE

TAF6L

1

Q9Y6J9
ERRFVEIPRESVRLM

TAF6L

6

Q9Y6J9
MDPDFVERRRIGLEN

SNX4

146

O95219
LKDPEELRNYMERIR

TMEM132A

1006

Q24JP5
PDEMRRRREEEGLQL

KPNA1

21

P52294
REKDMRRVRDEPEKV

ODAD4

521

Q96NG3
ERELRERMKPGFEVK

RERE

1316

Q9P2R6
REPRILSEEEQEMFR

PKN2

961

Q16513
KSEERPMTAEELRER

SPTY2D1

191

Q68D10
MEVDIEERPKELVRK

NOP16

76

Q9Y3C1
EQRVEIVPRDLRMKD

ALKAL2

81

Q6UX46
IVEELMEDDPRRAKE

CLHC1

276

Q8NHS4
KPPRREDIEMDEIIE

NCAPD3

181

P42695
MADGEEPEKKRRRIE

UBA3

1

Q8TBC4
ETPREEIARLRKMEL

PLEKHA6

891

Q9Y2H5
REAEEMKLEPLQERE

USP51

51

Q70EK9
DGRVELPERRSRMDL

TTBK1

466

Q5TCY1
MSEDEEKVKLRRLEP

STX17

1

P56962
DKLRLEIRAMDEIQP

VPS28

141

Q9UK41
EMIEKEQREVERRPI

PHF3

1036

Q92576
LKMNFRPERRVLVDD

PREPL

486

Q4J6C6
PVRFEDMKELTLERN

ZNF844

376

Q08AG5
KPIDMEKRESIQRRE

TRAPPC10

286

P48553
MPEEEERLGRKREQL

WDR87

1791

Q6ZQQ6
KEEEERRIAEMGRPI

SLC8A1

691

P32418
DQRIGELDRLIERME

MYZAP

296

P0CAP1