Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein-glutamine gamma-glutamyltransferase activity

TGM1 TGM3

6.30e-059272GO:0003810
GeneOntologyMolecularFunctionantigen binding

IGHV3-20 IGHV3-9 IGHV4-39 IGHV4-31

1.17e-04190274GO:0003823
GeneOntologyMolecularFunctionstructural constituent of eye lens

CRYBA2 CRYBA4

4.77e-0424272GO:0005212
GeneOntologyCellularComponentimmunoglobulin complex

IGHV3-20 IGHV3-9 IGHV4-39 IGHV4-31

5.84e-05166274GO:0019814
DomainTransglut_N

TGM1 TGM3

5.19e-059232PF00868
DomainTRANSGLUTAMINASES

TGM1 TGM3

5.19e-059232PS00547
DomainTransglutaminase_N

TGM1 TGM3

5.19e-059232IPR001102
DomainTransglut_C

TGM1 TGM3

5.19e-059232PF00927
Domain-

TGM1 TGM3

5.19e-0592323.90.260.10
DomainGln_gamma-glutamylTfrase_euk

TGM1 TGM3

5.19e-059232IPR023608
DomainTransglutaminase_AS

TGM1 TGM3

5.19e-059232IPR013808
DomainTransglutaminase_C

TGM1 TGM3

6.49e-0510232IPR008958
DomainTGc

TGM1 TGM3

7.92e-0511232SM00460
DomainTransglut_core

TGM1 TGM3

7.92e-0511232PF01841
DomainTransglutaminase-like

TGM1 TGM3

7.92e-0511232IPR002931
DomainCrystall

CRYBA2 CRYBA4

1.51e-0415232PF00030
DomainCRYSTALLIN_BETA_GAMMA

CRYBA2 CRYBA4

1.51e-0415232PS50915
DomainBeta/gamma_crystallin

CRYBA2 CRYBA4

1.51e-0415232IPR001064
DomainXTALbg

CRYBA2 CRYBA4

1.51e-0415232SM00247
DomainG_crystallin-rel

CRYBA2 CRYBA4

2.19e-0418232IPR011024
DomainGPS

ADGRE3 PKD1

7.95e-0434232SM00303
DomainGPS

ADGRE3 PKD1

8.42e-0435232PF01825
DomainGPS

ADGRE3 PKD1

8.91e-0436232PS50221
DomainGPS

ADGRE3 PKD1

9.41e-0437232IPR000203
DomainLAM_G_DOMAIN

CNTNAP4 NRXN2

9.93e-0438232PS50025
DomainLaminin_G_2

CNTNAP4 NRXN2

1.10e-0340232PF02210
DomainLamG

CNTNAP4 NRXN2

1.33e-0344232SM00282
DomainLDLRA_1

MAMDC4 PKD1

1.58e-0348232PS01209
DomainLDLRA_2

MAMDC4 PKD1

1.65e-0349232PS50068
Domain-

FMO4 CHDH

2.15e-03562323.50.50.60
DomainFAD/NAD-binding_dom

FMO4 CHDH

2.22e-0357232IPR023753
DomainLaminin_G

CNTNAP4 NRXN2

2.30e-0358232IPR001791
DomainConA-like_dom

CNTNAP4 NRXN2 MAMDC4

2.37e-03219233IPR013320
DomainEGF_3

CNTNAP4 NRXN2 ADGRE3

2.89e-03235233PS50026
DomainEGF

CNTNAP4 NRXN2 ADGRE3

2.89e-03235233SM00181
DomainEGF-like_dom

CNTNAP4 NRXN2 ADGRE3

3.40e-03249233IPR000742
Domain-

CNTNAP4 NRXN2

6.04e-03952322.60.120.200
DomainIg_E-set

TGM1 TGM3

7.20e-03104232IPR014756
DomainIg-like_fold

TGM1 TGM3 SEMA4B VSTM5

1.01e-02706234IPR013783
DomainEGF

CNTNAP4 NRXN2

1.04e-02126232PF00008
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGHV3-20 IGHV4-39 IGHV4-31

1.55e-0535203MM17219
PathwayREACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION

IGHV3-20 IGHV4-39 IGHV4-31

2.16e-0539203MM17212
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGHV3-20 IGHV4-39 IGHV4-31

3.34e-0545203MM14912
PathwayREACTOME_FCGR_ACTIVATION

IGHV3-20 IGHV4-39 IGHV4-31

4.06e-0548203MM17214
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGHV3-20 IGHV4-39 IGHV4-31

5.47e-0553203MM15716
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGHV3-20 IGHV4-39 IGHV4-31

5.78e-0554203MM14655
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGHV3-20 IGHV4-39 IGHV4-31

6.45e-0556203MM14815
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGHV3-20 IGHV4-39 IGHV4-31

7.17e-0558203MM14914
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGHV3-20 IGHV4-39 IGHV4-31

7.94e-0560203MM14913
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGHV3-20 IGHV4-39 IGHV4-31

7.94e-0560203MM14872
PathwayREACTOME_COMPLEMENT_CASCADE

IGHV3-20 IGHV4-39 IGHV4-31

2.16e-0484203MM14653
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGHV3-20 IGHV4-39 IGHV4-31

4.41e-04107203MM14915
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGHV3-20 IGHV4-39 IGHV4-31

5.31e-04114203MM14814
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGHV3-20 IGHV4-39 IGHV4-31

7.96e-04131203MM15717
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGHV3-20 IGHV4-39 IGHV4-31

8.69e-04135203MM14781
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

IGHV3-20 IGHV4-39 IGHV4-31

1.18e-03150203MM14889
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

IGHV3-20 IGHV4-39 IGHV4-31

1.37e-03158203MM14812
Pubmed

Chromosomal organization of the human VH4 gene family. Location of individual gene segments.

IGHV4-39 IGHV4-31 IGHV4-30-2

2.08e-0942938454861
Pubmed

Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium.

TGM1 TGM3

6.71e-07229214645372
Pubmed

Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus.

TGM1 TGM3

6.71e-07229230213231
Pubmed

Investigation of mouse amniotic fluid for stimulating ability of keratinocyte differentiation depending on the fetal stage.

TGM1 TGM3

6.71e-07229234390735
Pubmed

Differential expression of transglutaminase genes in patients with chronic periodontitis.

TGM1 TGM3

6.71e-07229224112124
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-20 IGHV4-39 IGHV4-31

7.94e-07222932499654
Pubmed

Low prevalence of IgA anti-transglutaminase 1, 2, and 3 autoantibodies in children with atopic dermatitis.

TGM1 TGM3

2.01e-06329224885370
Pubmed

Gene disruption of tissue transglutaminase.

TGM1 TGM3

2.01e-06329211113189
Pubmed

Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.

TGM1 TGM3

2.01e-06329227649154
Pubmed

Hornerin is a component of the epidermal cornified cell envelopes.

TGM1 TGM3

2.01e-06329221282207
Pubmed

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.

TGM1 TGM3

2.01e-06329223189155
Pubmed

SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases.

TGM1 TGM3

2.01e-06329215304086
Pubmed

Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3.

TGM1 TGM3

2.01e-06329215715085
Pubmed

Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse.

TGM1 TGM3

4.02e-0642928828830
Pubmed

TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation.

TGM1 TGM3

4.02e-06429239146185
Pubmed

Lack of 'tissue' transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: relationship to development of autoimmunity in MRLIpr/Ipr mice.

TGM1 TGM3

4.02e-06429216465267
Pubmed

Regulated expression of tissue transglutaminase in Swiss 3T3 fibroblasts: effects on the processing of fibronectin, cell attachment, and cell death.

TGM1 TGM3

4.02e-0642929511731
Pubmed

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).

TGM1 TGM3

6.70e-0652929448282
Pubmed

Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice.

CRYBA2 CRYBA4

1.00e-0562929693140
Pubmed

Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice.

TGM1 TGM3

1.00e-05629222258055
Pubmed

The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5.

CRYBA2 CRYBA4

1.00e-0562927789995
Pubmed

Amino acid sequence of the precursor region of MOPC-315 mouse immunoglobulin heavy chain.

IGHV4-39 IGHV4-31

1.41e-057292414225
Pubmed

Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5.

CRYBA2 CRYBA4

1.41e-0572928575764
Pubmed

Cloning, sequencing and expression of the rearranged MOPC 315 VH gene segment.

IGHV4-39 IGHV4-31

1.41e-0572922497341
Pubmed

Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.

TGM1 TGM3

1.41e-05729211390390
Pubmed

A new germline VH36-60 gene is used in the neonatal primary and adult memory response to (T,G)-A--L.

IGHV4-39 IGHV4-31

1.41e-0572921683681
Pubmed

The idiotypic network and the internal image: possible regulation of a germ-line network by paucigene encoded Ab2 (anti-idiotypic) antibodies in the GAT system.

IGHV4-39 IGHV4-31

1.41e-0572923937730
Pubmed

Model-building studies of antigen-binding sites: the hapten-binding site of mopc-315.

IGHV4-39 IGHV4-31

1.41e-057292268248
Pubmed

The structure of the expressible VH gene from a hybridoma producing monoclonal antibodies against porcine transferrin.

IGHV4-39 IGHV4-31

1.41e-0572922587273
Pubmed

Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.

IGHV4-39 IGHV4-31

1.41e-0572924524622
Pubmed

HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.

TGM1 TGM3

1.87e-0582927906657
Pubmed

Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.

TGM1 TGM3

1.87e-0582927688299
Pubmed

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.

TGM1 TGM3

3.01e-051029216192310
Pubmed

Structure and function of immunoglobulin genes and precursors.

IGHV4-39 IGHV4-31

3.01e-0510292428562
Pubmed

Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life.

TGM1 TGM3

3.01e-051029226975724
Pubmed

IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.

IGHV3-20 IGHV4-39 IGHV4-31

3.66e-057729315608191
Pubmed

The upstream ectoderm enhancer in Pax6 has an important role in lens induction.

CRYBA2 CRYBA4

3.68e-051129211714668
Pubmed

Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions.

CRYBA2 CRYBA4

3.68e-051129210595510
Pubmed

The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.

IGHV3-20 IGHV3-9 IGHV4-39

6.03e-05912939841928
Pubmed

The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.

CRYBA2 CRYBA4

6.07e-051429221998302
Pubmed

Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.

CRYBA2 CRYBA4

8.00e-051629215593327
Pubmed

Regulation of mouse lens fiber cell development and differentiation by the Maf gene.

CRYBA2 CRYBA4

9.06e-051729210603348
Pubmed

Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation.

CRYBA2 CRYBA4

1.02e-041829216162653
Pubmed

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.

TGM1 TGM3

1.40e-042129218824566
Pubmed

ZFP750 affects the cutaneous barrier through regulating lipid metabolism.

TGM1 TGM3

3.08e-043129237115925
Pubmed

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus.

IGHV3-20 IGHV3-9

4.88e-04392928490662
Cytoband14q32.33

IGHV3-20 IGHV3-9 IGHV4-39 IGHV4-31 IGHV4-30-2

3.12e-0722829514q32.33
Cytoband22q13.1

TNRC6B CACNA1I

1.33e-038529222q13.1
CytobandEnsembl 112 genes in cytogenetic band chr14q32

IGHV3-20 IGHV4-39 IGHV4-31

5.37e-03566293chr14q32
GeneFamilyImmunoglobulin heavy locus at 14q32.33

IGHV3-20 IGHV3-9 IGHV4-39 IGHV4-31 IGHV4-30-2

2.56e-06187225349
GeneFamilyTransglutaminases

TGM1 TGM3

5.06e-059222773
GeneFamilyBeta-gamma crystallins

CRYBA2 CRYBA4

1.47e-04152221359
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B JPH3

4.17e-0425222775
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

CRYBA4 IGHV3-20 IGHV3-9 IGHV4-39

2.78e-06152294a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPS6KA6 CRYBA2 TGM3 SSTR2

4.34e-0617029402f0be0aab8ba2d35a83238609352ef3677511c9
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPS6KA6 CRYBA2 TGM3 SSTR2

4.65e-0617329407798461d12d04f3dabff03481c999cb07c5af2f
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPS6KA6 CRYBA2 TGM3 SSTR2

4.65e-06173294f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ SSTR2

6.06e-06185294eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ SSTR2

6.46e-06188294ed074572e61d97c139fb1636a78c9b71e2c44ce0
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS6KA6 IGHV3-20 IGHV3-9

7.43e-05126293518a6e4919981b556ce6b451a91270dba976bc75
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRYBA2 TGM3 SSTR2

1.08e-0414329336ce6f163fb33141c86288086c354b91853fad25
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

RPS6KA6 SLC30A2 CHDH

1.22e-04149293d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCellHealthy_donor-B_cell|World / disease group, cell group and cell class (v2)

SEMA4B CHDH JPH3

1.25e-04150293a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCellfacs-Marrow-KLS-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 MAMDC4 PKD1

1.42e-041572935d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCellfacs-Marrow-KLS-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 MAMDC4 PKD1

1.42e-04157293ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRYBA2 TGM3 CACNA1I

1.42e-041572935aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 PERCC1

1.56e-04162293f2a87019ff9b466617e90c60d182ab7d14581cc9
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-6|TCGA-Adrenal / Sample_Type by Project: Shred V9

FMO4 SLC30A2 CLN3

1.56e-041622930e8fb83acb8ea9905cc3ca985feb8a00931549ff
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B CACNA1I SLC30A2

1.68e-041662933e3e9296e6919a38602e417a6606c046af3bd101
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPS6KA6 CRYBA2 SSTR2

1.71e-041672935accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4B CACNA1I SLC30A2

1.71e-041672933c3e1c31aacca48099693aea2efdfa22fc0e4af4
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-Zbtb32+_B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4B CACNA1I SLC30A2

1.71e-0416729377a4d7ce44847c76074d4f5340d61b398fe43e6c
ToppCell10x5'-GI_large-bowel|World / Manually curated celltypes from each tissue

CRYBA2 IGHV4-39 IGHV4-30-2

1.74e-041682931290c909655bc37f6b8bf216d18127a21b99e9c0
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

1.74e-0416829332e0bc0873baa13027241063283ef26d2aab56f5
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

1.74e-041682934e1b522c7400c9d87f63c00e4e1dd07136095cd6
ToppCelldroplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

1.74e-04168293e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

1.74e-0416829338ba7737ae0afffcbd3aa499403e83c24a922127
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGHV3-20 IGHV4-39 IGHV4-31

1.77e-04169293307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

CRYBA4 IGHV4-39 IGHV4-31

1.77e-04169293b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CRYBA2 TGM3 SSTR2

1.80e-0417029367415b098e8ba815b501e557192a9f2b10ee995a
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4B NRXN2 CHDH

1.90e-041732934f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA4B NRXN2 CHDH

1.90e-041732939bbea566964281f47bf75d665b7d69ba8326e207
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-20 IGHV4-39 IGHV4-30-2

1.90e-041732937e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCellmetastatic_Brain-B_lymphocytes-MALT_B_cells|metastatic_Brain / Location, Cell class and cell subclass

IGHV3-20 IGHV4-39 IGHV4-31

2.00e-0417629350e207403d48ce1b55a78897adb5519a2430a626
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 SSTR2

2.00e-041762932e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCellControl-Lymphoid_P|Control / Disease group, lineage and cell class

IGHV3-9 IGHV4-39 IGHV4-31

2.00e-04176293d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCellControl-Lymphoid_P-Plasmablast|Control / Disease group, lineage and cell class

IGHV3-9 IGHV4-39 IGHV4-31

2.00e-041762934b4416f342b732d2cc60133838728880326257d8
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 SSTR2 PERCC1

2.03e-041772938dbef0005095c01a806d8c7f723dc48a4650efec
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IGHV3-20 IGHV4-39 IGHV4-31

2.03e-04177293ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

2.10e-041792938ce5000088b727783a0619baa16a2cd036d21f54
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

2.10e-04179293f2e8fc975c30992611630197b79daaeef7c4211d
ToppCellwk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CRYBA2 SSTR2 PERCC1

2.10e-0417929306f92c884189197c86793191c05f65e34925c097
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

2.10e-04179293ec7c38464863ac3744a8d4880f49421914892339
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.13e-0418029382965ed1b72a1873c24dd4553d39681596057316
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.13e-04180293bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.13e-04180293839defb40f7cfb2711e9025194de636533f51bcd
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 TGM3 ARSJ

2.17e-041812932392af8c7f040c23a7d416c2e37419954970c8f4
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CRYBA2 SSTR2 PERCC1

2.17e-04181293cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

SEMA4B VSTM5 ARSJ

2.17e-041812938fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.17e-04181293fb64da1dde37fe6ba7de2586cd58848ac1974f24
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-20 IGHV4-39 IGHV4-30-2

2.17e-04181293e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.17e-04181293e2481291c236105774c53883e6f20da11941df9b
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA4B NRXN2 CHDH

2.17e-04181293782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

IGHV3-20 IGHV4-39 IGHV4-31

2.24e-04183293dea119e2988e954475f557f0bbe12556a83e81a4
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTNAP4 VSTM5 MAMDC4

2.24e-04183293b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-20 IGHV4-39 IGHV4-30-2

2.31e-0418529308bc817908076734d66f2805cb954141f2cc5a18
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRYBA4 IGHV3-20 IGHV4-39

2.31e-041852930fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CRYBA4 IGHV3-20 IGHV4-39

2.31e-0418529379edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHV3-20 IGHV4-39 IGHV4-30-2

2.31e-041852931704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Immature_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-20 IGHV4-39 IGHV4-30-2

2.35e-04186293459a7e97bbac2b2cd253aa4ab38d0e4ae6191e8b
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-20 IGHV4-39 IGHV4-30-2

2.50e-0419029318762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-20 IGHV4-39 IGHV4-30-2

2.50e-0419029379ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CRYBA2 SSTR2 PERCC1

2.50e-04190293b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell5'-Adult-LargeIntestine-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGHV3-20 IGHV4-39 IGHV4-30-2

2.54e-04191293d1d30279ed4612b4f62c225d9eabf0b8a7a09d11
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-20 IGHV3-9 IGHV4-31

2.62e-041932937b4b0271e4fbece703876acb053ae236afb7cdba
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.62e-04193293282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.62e-0419329334f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.66e-041942936ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.66e-04194293a4a70369541876e1192df8828b63e3d1746ae3d9
ToppCellBiopsy_Other_PF-Immune-Plasma_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

IGHV3-20 IGHV4-39 IGHV4-31

2.70e-04195293d0305c6a68c9e361507b04db94f86873085d49b3
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.74e-04196293c2e17f3b2217f20bd7f28a1db4aa7d9a95c52a9c
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGHV3-20 IGHV3-9 IGHV4-39

2.74e-04196293026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.74e-04196293c38e7f533c619afe008de0e99042f7180c2da918
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IGHV3-20 IGHV4-39 IGHV4-31

2.74e-04196293a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.74e-04196293e9fe5090452ffdde4bb81b62d57037d823281d00
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.74e-04196293fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-0419729388b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCellBiopsy_Control_(H.)-Immune-Plasma_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-04197293275f38ed7e477000e864cecf9b7d49ae134c3b6a
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-041972939fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-041972932662138671262b30508c5759038bcdcfe6551696
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-041972931e63879633f20646e44873ae6b662f6faf4806fd
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.78e-0419729376465bb2408c7c75f694e8f7cf1a606b796afc3a
ToppCellCOVID_vent-Lymphocytic-Plasma_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGHV3-20 IGHV3-9 IGHV4-39

2.82e-04198293e84c5f712e1dea548d0e2aba6625598f9671d3a0
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.82e-0419829379c690d21d3420d0bb1a3b3b4ea2c9aa3810a219
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-20 IGHV4-39 IGHV4-31

2.86e-041992938e02d3a066e79e0f2024a10738e0ea070513ef19
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

ARSJ MAMDC4

4.26e-044729259811807a4b5baec55505bb4c38ac684b0a49c9a
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

ARSJ MAMDC4

4.26e-044729274ed0dc55bcfe6e5f7bab42ee060692d51a39e5a
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cacna2d1_(generic_SN/VTA_glutamatergic_neuron)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TGM1 TGM3

5.02e-0451292442ca235753f8b41d004a7d53e6eb0e1b3781512
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Cacna2d1_(generic_SN/VTA_glutamatergic_neuron)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TGM1 TGM3

5.02e-04512921c9b2af8abe1b694abea65bd4c2a26fae2d01ab3
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Kif5b_(Kif5b)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAMDC4 CHDH

7.65e-0463292c30197502348f07ded57ad4e50862e61e2fba51e
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Kif5b_(Kif5b)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAMDC4 CHDH

7.65e-046329250ea93ea08d8e7a1a2508e8a2c569f6f5dc91961
ComputationalNeighborhood of SPRR1B

TGM1 TGM3

2.60e-0424112GNF2_SPRR1B
Diseasebipolar disorder, body mass index

CLN3 JPH3

1.70e-0372252EFO_0004340, MONDO_0004985
Diseasebehavioural disinhibition measurement

CACNA1I ARSJ

1.84e-0375252EFO_0006946
Diseasebitter alcoholic beverage consumption measurement

TNRC6B NRXN2

5.65e-03133252EFO_0010092
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP4 NRXN2

7.32e-03152252DOID:0060041 (implicated_via_orthology)
Diseasecardiac troponin I measurement

TMTC2 JPH3

9.70e-03176252EFO_0010071

Protein segments in the cluster

PeptideGeneStartEntry
DPCGWRDISTSGYSW

MAMDC4

71

Q6UXC1
WVGRTNETQTYWGGS

CNTNAP4

701

Q9C0A0
EKGDYPRWSAWSGSS

CRYBA2

71

P53672
YWPRGRVWGGSSSLN

CHDH

121

Q8NE62
GSISSGGYYWSWIRQ

IGHV4-31

46

P0DP07
GSNWPLRGSKGTYWE

ARSJ

336

Q5FYB0
WVSGISWNSGSIGYA

IGHV3-9

66

P01782
GSISSGGYSWSWIRQ

IGHV4-30-2

46

A0A087WSY4
GLQQYWGSRAAAGWS

PERCC1

181

A0A1W2PR82
SSSSYYWGWIRQPPG

IGHV4-39

56

P01824
TGTWVLGRSSDWGYP

FMO4

216

P31512
GQWARYARWAGAASS

NRXN2

36

Q9P2S2
WVSGINWNGGSTGYA

IGHV3-20

66

A0A0C4DH32
NRRGHSQSADWWSYG

RPS6KA6

246

Q9UK32
RSSYYGPWGRSAAWA

CACNA1I

971

Q9P0X4
RGEYPSWDAWGGNTA

CRYBA4

71

P53673
AYSAPDLLGAWSWGS

PKD1

3796

P98161
PAGGKASWGADRSYW

SEMA4B

701

Q9NPR2
SSCTINWPGESGAWY

SSTR2

191

P30874
NWSGTYTGGRDPRSW

TGM3

236

Q08188
YWKSTGQGSQWSRDG

ADGRE3

306

Q9BY15
IVRNSWGSSWGVDGY

CTSO

286

P43234
YPRAVISWWSSGTGG

CLN3

176

Q13286
GVPTIEWTYSSNWGT

VSTM5

61

A8MXK1
TRGYSARTWGWFLGS

TMTC2

161

Q8N394
NWSGDYSRGTNPSAW

TGM1

341

P22735
STWSDGGSVRPSYWL

TNRC6B

1636

Q9UPQ9
IRSYTGSLWQEGAGW

SLC30A2

16

Q9BRI3
GVYTWPSGNTYQGTW

JPH3

51

Q8WXH2