Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.66e-0825234GO:0055056
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.66e-0825234GO:0015149
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC5A11 SLC2A1 SLC5A1 SLC5A4

2.31e-0827234GO:0015145
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC5A11 SLC2A1 SLC5A1 SLC5A4

3.12e-0829234GO:0051119
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A11 SLC5A1 SLC5A4

4.66e-087233GO:0005412
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.45e-0742234GO:0015144
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC5A11 SLC5A1 SLC5A4

8.98e-0717233GO:0005402
GeneOntologyMolecularFunctionmyo-inositol transmembrane transporter activity

SLC5A11 SLC5A1

7.60e-064232GO:0005365
GeneOntologyMolecularFunctionpolyol transmembrane transporter activity

SLC5A11 SLC5A1

9.82e-0513232GO:0015166
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC5A11 SLC5A1 SLC5A4

1.07e-0481233GO:0015370
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC5A11 SLC5A1 SLC5A4

3.35e-04119233GO:0015294
GeneOntologyMolecularFunctionsymporter activity

SLC5A11 SLC5A1 SLC5A4

6.59e-04150233GO:0015293
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC5A11 SLC5A1 SLC5A4

9.63e-04171233GO:0015081
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC5A11 CACNA1B SLC5A1 SLC5A4

1.81e-03465234GO:0046873
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

SLC5A11 SLC5A1

2.92e-0370232GO:1901618
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC5A11 SLC5A1 SLC5A4

4.58e-03296233GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC5A11 SLC5A1 SLC5A4

4.80e-03301233GO:0022853
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC5A11 CACNA1B SLC5A1 SLC5A4

5.30e-03627234GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC5A11 CACNA1B SLC5A1 SLC5A4

6.48e-03664234GO:0008324
GeneOntologyMolecularFunctionmonooxygenase activity

CYP4Z1 CYP4Z2P

7.69e-03115232GO:0004497
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC5A11 CACNA1B SLC2A1 SLC5A1 SLC5A4

9.85e-031180235GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC5A11 CACNA1B SLC5A1 SLC5A4

1.03e-02758234GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC5A11 CACNA1B SLC5A1 SLC5A4

1.20e-02793234GO:0015075
GeneOntologyMolecularFunctionheme binding

CYP4Z1 CYP4Z2P

1.34e-02154232GO:0020037
GeneOntologyMolecularFunctiontransporter activity

SLC5A11 CACNA1B SLC2A1 SLC5A1 SLC5A4

1.41e-021289235GO:0005215
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP4Z1 CYP4Z2P

1.51e-02164232GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP4Z1 CYP4Z2P

1.55e-02166232GO:0005506
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC5A11 SLC5A1 SLC5A4

1.68e-02477233GO:0022804
GeneOntologyBiologicalProcessmyo-inositol transport

SLC5A11 SLC5A1

1.08e-055222GO:0015798
GeneOntologyBiologicalProcessD-glucose import across plasma membrane

SLC2A1 SLC5A1

1.08e-055222GO:0098708
GeneOntologyBiologicalProcesshexose import across plasma membrane

SLC2A1 SLC5A1

1.62e-056222GO:0140271
GeneOntologyBiologicalProcesscarbohydrate import across plasma membrane

SLC2A1 SLC5A1

1.62e-056222GO:0098704
GeneOntologyBiologicalProcessD-glucose transmembrane transport

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.68e-05148224GO:1904659
GeneOntologyBiologicalProcesshexose transmembrane transport

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.82e-05151224GO:0008645
GeneOntologyBiologicalProcessmonosaccharide transmembrane transport

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.97e-05154224GO:0015749
GeneOntologyBiologicalProcesscarbohydrate transmembrane transport

SLC5A11 SLC2A1 SLC5A1 SLC5A4

2.77e-05168224GO:0034219
GeneOntologyBiologicalProcesscarbohydrate transport

SLC5A11 SLC2A1 SLC5A1 SLC5A4

4.12e-05186224GO:0008643
DomainNA_SOLUT_SYMP_1

SLC5A11 SLC5A1 SLC5A4

2.33e-0711223PS00456
DomainSSF

SLC5A11 SLC5A1 SLC5A4

3.10e-0712223PF00474
DomainNa/solute_symporter

SLC5A11 SLC5A1 SLC5A4

3.10e-0712223IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A11 SLC5A1 SLC5A4

3.10e-0712223PS50283
DomainNA_SOLUT_SYMP_2

SLC5A11 SLC5A1 SLC5A4

3.10e-0712223PS00457
DomainNa/solute_symporter_CS

SLC5A1 SLC5A4

3.69e-058222IPR018212
DomainUbiquitin-rel_dom

PIK3CG FAF1 UBQLN2

1.26e-03184223IPR029071
DomainARM-type_fold

PIK3CG MROH2B UBQLN2

7.07e-03339223IPR016024
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC2A1 SLC5A1 SLC5A4

1.15e-0619163MM14718
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC2A1 SLC5A1 SLC5A4

1.58e-0621163M27058
PathwayWP_NRF2_PATHWAY

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.59e-05141164M39454
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.23e-04238164MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC5A11 SLC2A1 SLC5A1 SLC5A4

1.46e-04249164M5988
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC5A11 SLC2A1 SLC5A1 SLC5A4

3.56e-04314164M39428
PathwayWP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR

PTGER2 PIK3CG

3.57e-0425162M39794
PathwayWP_PROSTAGLANDIN_SIGNALING

PTGER2 PIK3CG

6.25e-0433162M42532
PathwayWP_OPIOID_RECEPTOR_PATHWAYS

CACNA1B PIK3CG

9.65e-0441162M48338
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1B PIK3CG

1.27e-0347162M19708
Pubmed

The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.

CYP4Z1 CYP4Z2P

4.18e-07223225701119
Pubmed

The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.

CYP4Z1 CYP4Z2P

4.18e-07223228236635
Pubmed

Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.

CYP4Z1 CYP4Z2P

4.18e-07223215059886
Pubmed

Characterization and modulation of glucose uptake in a human blood-brain barrier model.

SLC2A1 SLC5A1

1.25e-06323223975336
Pubmed

Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium.

SLC5A1 SLC5A4

1.25e-06323211749115
Pubmed

Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs.

SLC5A1 SLC5A4

1.25e-06323223926132
Pubmed

Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.

CYP4Z1 CYP4Z2P

1.25e-06323230832689
Pubmed

Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes.

SLC2A1 SLC5A1

2.51e-06423232617672
Pubmed

KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

SLC5A11 SLC5A1

4.18e-06523224595108
Pubmed

Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy.

SLC2A1 SLC5A1

8.77e-06723236465606
Pubmed

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.

SLC2A1 SLC5A1

1.50e-05923236917198
Pubmed

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

SLC2A1 SLC5A1

9.59e-052223220965718
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

FAF1 UBQLN2 EPG5

1.31e-0415023332423001
Pubmed

Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.

CACNA1B SLC2A1

2.05e-043223219320717
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

SLC2A1 SLC5A1

5.44e-045223226590417
InteractionOR2T12 interactions

OR2T12 OR2T33

1.03e-062212int:OR2T12
InteractionOR2T33 interactions

OR2T12 OR2T33

3.10e-063212int:OR2T33
Cytoband1p33

CYP4Z1 CYP4Z2P FAF1

7.11e-07352331p33
Cytoband22q12.3

SLC5A1 SLC5A4

1.26e-043323222q12.3
CytobandEnsembl 112 genes in cytogenetic band chr1p33

CYP4Z1 CYP4Z2P

4.32e-0461232chr1p33
Cytoband1q44

OR2T12 OR2T33

1.39e-031102321q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T12 OR2T33

1.88e-03128232chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr22q12

SLC5A1 SLC5A4

6.15e-03235232chr22q12
GeneFamilyCytochrome P450 family 4

CYP4Z1 CYP4Z2P

7.16e-04362021003
GeneFamilySolute carriers

SLC5A11 SLC2A1 SLC5A1 SLC5A4

8.24e-04395204752
GeneFamilyOlfactory receptors, family 2

OR2T12 OR2T33

6.84e-03113202149
Drugphlorizine

SLC5A11 SLC2A1 SLC5A1 SLC5A4

9.36e-0779224CID000004789
Drugtolbutamide

SLC5A11 CYP4Z1 SLC2A1 SLC5A1 SLC5A4

1.10e-06198225CID000005505
Druggentamicin C

SLC2A1 SLC5A1

2.67e-063222ctd:C100093
Drug2-deoxy-D-galactopyranose

SLC5A11 SLC2A1 SLC5A1 SLC5A4

3.53e-06110224CID000000040
Drug3-OMG

SLC5A11 SLC2A1 SLC5A1

4.19e-0633223CID000097217
Drugmeloxicam

SLC5A11 SLC2A1 SLC5A1

7.56e-0640223ctd:C065757
Drug3-O-methyl-D-glucose

PIK3CG SLC2A1 SLC5A1

4.47e-0572223CID000008973
Drugindoxyl-beta-D-glucoside

SLC5A1 SLC5A4

1.20e-0417222CID000092769
Drugsodium chloride

SLC5A11 PIK3CG SLC2A1 UBQLN2 SLC5A1 SLC5A4

1.31e-04865226CID000000206
Drugalpha-methyl-D-mannoside

SLC2A1 SLC5A1 SLC5A4

1.85e-04116223CID000002108
DrugTF-3

SLC2A1 SLC5A1

1.85e-0421222CID006102763
Drugcarboxymethylcellulose

SLC5A11 SLC5A1 SLC5A4

1.94e-04118223CID000024748
Disease10-undecenoate 11:1n1 measurement

CYP4Z1 CYP4Z2P

1.11e-057222EFO_0021099
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

UBQLN2 EPG5

2.28e-0430222DOID:332 (implicated_via_orthology)
Diseaseejection fraction measurement

SLC5A11 PTGER2

4.70e-0443222EFO_0005527
DiseaseGlobal developmental delay

CACNA1B SLC2A1

4.39e-03133222C0557874
Diseaseovarian neoplasm

SLC2A1 BCL9

4.46e-03134222C0919267
DiseaseMalignant neoplasm of ovary

SLC2A1 BCL9

4.65e-03137222C1140680

Protein segments in the cluster

PeptideGeneStartEntry
IFITMMSKSVRMMLN

CYP4Z2P

151

Q8N1L4
LSSLFMEVLMMMNNA

EPG5

2266

Q9HCE0
FIMAMIALNTVVLMM

CACNA1B

1476

Q00975
PMYFLLSQLSLMDMM

OR2T12

56

Q8NG77
LIMKTNMLVQFLMEM

MAGEB3

111

O15480
MLMMNLLAFVSAVLM

SLC2A1

96

P11166
MTFFSLATMLMLFAM

PTGER2

116

P43116
PMYFLLSQLSLMDMM

OR2T33

56

Q8NG76
LSIMMSRMSKFAMPS

BCL9

1006

O00512
ILTALMSLSMGITMM

MS4A4A

71

Q96JQ5
LMMRLMAAMEIFTAQ

FAF1

476

Q9UNN5
MLLPAIMFSVSAAMM

SCAMP4

151

Q969E2
MMLSLFIMATLMTLN

MT-ND4L

36

P03901
MSFMMELKMLLEVAL

FANCL

81

Q9NW38
LMLSVMLASLMSSLT

SLC5A4

381

Q9NY91
LMMAVMVAALMSSLT

SLC5A11

376

Q8WWX8
VSQSIPFMMMTLLTM

MROH2B

121

Q7Z745
PFMMMTLLTMQTMLR

MROH2B

126

Q7Z745
FHLFPALMMLSMTML

SEMA3D

16

O95025
ALMMLSMTMLFLPVT

SEMA3D

21

O95025
IFITMMSESVRMMLN

CYP4Z1

151

Q86W10
LLIILFSMMLMTGMP

PIK3CG

1026

P48736
MSMSANTMIFMILGA

TMEM240

1

Q5SV17
MMVIFLVGLVSMILM

TM9SF3

231

Q9HD45
MLSAPYMRSMMQSLS

UBQLN2

386

Q9UHD9
LMLSVMLASLMSSLT

SLC5A1

381

P13866