Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2 ITPR3

6.85e-0731773GO:0005220
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR3 ITPR1 ITPR2 ITPR3

1.66e-05181774GO:0015278
GeneOntologyMolecularFunctionglycerol channel activity

AQP7B AQP7P3 AQP7

2.33e-0571773GO:0015254
GeneOntologyMolecularFunctionurea transmembrane transporter activity

AQP7B AQP7P3 AQP7

5.53e-0591773GO:0015204
GeneOntologyMolecularFunctionglycerol transmembrane transporter activity

AQP7B AQP7P3 AQP7

5.53e-0591773GO:0015168
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR3 ITPR1 ITPR2 ITPR3

1.56e-04311774GO:0099604
GeneOntologyMolecularFunctionpolyol transmembrane transporter activity

AQP7B AQP7P3 AQP7

1.83e-04131773GO:0015166
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR3 ITPR1 ITPR2 ITPR3

2.00e-04331774GO:0005217
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2 ITPR3

2.32e-04141773GO:0070679
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH1 MYH4 MYH7B MYO15A

3.48e-04381774GO:0000146
GeneOntologyMolecularFunctionATP-dependent activity

MYH1 MYH4 MYH7B ZGRF1 SMCHD1 RHOBTB3 CHD4 ATP6V0D1 STARD9 CHD5 CHD6 KIF5A ATP6V0D2 ATP1A1 MYO15A

3.88e-0461417715GO:0140657
GeneOntologyMolecularFunctionwater channel activity

AQP7B AQP7P3 AQP7

4.25e-04171773GO:0015250
GeneOntologyMolecularFunctionamide transmembrane transporter activity

AQP7B AQP7P3 AQP7 SLC38A3

5.14e-04421774GO:0042887
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH1 MYH4 MYH7B STARD9 KIF5A MYO15A

6.47e-041181776GO:0003774
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PDE2A INPP5D PTPN23 CTDNEP1 PPM1H PTPN13 PTPRE NT5C2 PLD2 ATP1A1 PLCH1

6.82e-0438617711GO:0042578
GeneOntologyMolecularFunctionwater transmembrane transporter activity

AQP7B AQP7P3 AQP7

6.99e-04201773GO:0005372
GeneOntologyMolecularFunctionurea channel activity

AQP7P3 AQP7

7.68e-0451772GO:0015265
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

7.68e-0451772GO:0140444
GeneOntologyMolecularFunctionactin filament binding

MYH1 MYH4 MYH7B SYNE1 SPTA1 SPTBN2 LRPPRC MYO15A

9.70e-042271778GO:0051015
GeneOntologyMolecularFunctionsingle-stranded DNA 3'-5' DNA exonuclease activity

EXO5 POLE

1.14e-0361772GO:0008310
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNMB2 AQP7B AQP7P3 SLC1A2 AQP7 RYR3 ITPR1 ITPR2 ITPR3 ATP6V0D1 KCNS3 ATP6V0D2 ATP1A1 APOL2 ANO3 SLC38A3

1.19e-0375817716GO:0015318
GeneOntologyMolecularFunctionactin binding

MYH1 MYH4 MAP2 MYH7B SYNE1 SPTA1 SPTBN2 SYNPO LRPPRC INF2 SYNE2 MYO15A

1.20e-0347917712GO:0003779
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYH1 MYH4 MAP2 CENPF MYH7B SYNE1 SPTA1 SPTBN2 SYNPO FARP2 CCDC88C LRPPRC INF2 STARD9 SYNE2 GOLGA8B KIF5A ATP1A1 MYO15A MAPK8IP2

1.81e-03109917720GO:0008092
GeneOntologyCellularComponentlipid droplet

STARD13 SET VPS13C AQP7P3 CTDNEP1 AQP7 BCAP31 SETSIP PLIN3

6.71e-071161789GO:0005811
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2 ITPR3

4.91e-0591783GO:0031095
GeneOntologyCellularComponentmyosin filament

MYH1 MYH4 MYOM1 MYH7B

5.59e-05251784GO:0032982
GeneOntologyCellularComponentplasma membrane proton-transporting V-type ATPase complex

ATP6V0D1 ATP6V0D2

7.21e-0521782GO:0033181
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2 ITPR3

9.53e-05111783GO:0031094
GeneOntologyCellularComponentsarcoplasmic reticulum

CMYA5 RYR3 ITPR1 ITPR2 ITPR3 SYNE2

1.07e-04881786GO:0016529
GeneOntologyCellularComponentorganelle outer membrane

PDE2A VPS13C SYNE1 QTRT2 CPT1B ITPR3 LRPPRC SYNE2 MUL1 RHOT1

1.45e-0427917810GO:0031968
GeneOntologyCellularComponentmyosin complex

MYH1 MYH4 MYH7B MYH16 MYO15A

1.46e-04591785GO:0016459
GeneOntologyCellularComponentouter membrane

PDE2A VPS13C SYNE1 QTRT2 CPT1B ITPR3 LRPPRC SYNE2 MUL1 RHOT1

1.54e-0428117810GO:0019867
GeneOntologyCellularComponentnuclear outer membrane

SYNE1 ITPR3 LRPPRC SYNE2

3.66e-04401784GO:0005640
GeneOntologyCellularComponentactin cytoskeleton

MYH1 MYH4 CALB2 MAP2 MYH7B INPP5D SPTA1 SPTBN2 SYNPO AFAP1L1 DOCK5 INF2 MYH16 MYO15A

4.32e-0457617814GO:0015629
GeneOntologyCellularComponentsarcoplasm

CMYA5 RYR3 ITPR1 ITPR2 ITPR3 SYNE2

4.37e-041141786GO:0016528
GeneOntologyCellularComponentmyofibril

MYH1 MYH4 MYOM1 MYH7B SYNE1 SYNPO CMYA5 RYR3 SYNE2

5.72e-042731789GO:0030016
GeneOntologyCellularComponentcation-transporting ATPase complex

TMEM199 ATP6V0D1 ATP6V0D2 ATP1A1

7.99e-04491784GO:0090533
GeneOntologyCellularComponenthistone deacetylase complex

NRIP1 SIN3B CHD4 CHD5 TET1

8.01e-04851785GO:0000118
GeneOntologyCellularComponentcontractile muscle fiber

MYH1 MYH4 MYOM1 MYH7B SYNE1 SYNPO CMYA5 RYR3 SYNE2

8.79e-042901789GO:0043292
GeneOntologyCellularComponentperinuclear region of cytoplasm

PDE2A SET CENPF SYNE1 SPTBN2 CMYA5 RYR3 ITPR1 ITPR3 LRPPRC FAT1 BCAP31 INF2 SBF2 NFKBIE TENM1 GOLGA8B KIF5A

1.06e-0393417818GO:0048471
GeneOntologyCellularComponentATPase dependent transmembrane transport complex

TMEM199 ATP6V0D1 ATP6V0D2 ATP1A1

1.24e-03551784GO:0098533
GeneOntologyCellularComponentsarcomere

MYH1 MYH4 MYOM1 SYNE1 SYNPO CMYA5 RYR3 SYNE2

1.36e-032491788GO:0030017
GeneOntologyCellularComponentvacuolar proton-transporting V-type ATPase complex

TMEM199 ATP6V0D1 ATP6V0D2

1.37e-03261783GO:0016471
GeneOntologyCellularComponentmyosin II complex

MYH1 MYH4 MYH7B

1.70e-03281783GO:0016460
GeneOntologyCellularComponentproton-transporting V-type ATPase complex

TMEM199 ATP6V0D1 ATP6V0D2

1.88e-03291783GO:0033176
GeneOntologyCellularComponentexcitatory synapse

CALB2 SPTBN2 SYNDIG1 CHD4 C1QL2

2.23e-031071785GO:0060076
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTA1 SPTBN2

2.50e-0391782GO:0014731
GeneOntologyCellularComponentspectrin

SPTA1 SPTBN2

2.50e-0391782GO:0008091
GeneOntologyCellularComponentcell body

RELN COPA MAP2 RTN4 SPTBN2 L1CAM SYNDIG1 SYNPO SLC1A2 ITPR1 ITPR3 CD3E PTPN13 GOLGA8B KIF5A MUL1 MAPK8IP2

2.52e-0392917817GO:0044297
GeneOntologyCellularComponentCOPI-coated vesicle

COPA TMEM199 TMED10

2.75e-03331783GO:0030137
GeneOntologyCellularComponentcluster of actin-based cell projections

CALB2 CDH23 AQP7P3 AQP7 ITPR3 PLD2 MYO15A

3.06e-032231787GO:0098862
GeneOntologyCellularComponentnuclear membrane

CENPF SYNE1 CTDNEP1 ZBTB1 ITPR1 ITPR3 LRPPRC YEATS4 SYNE2

3.11e-033491789GO:0031965
GeneOntologyCellularComponentnuclear periphery

MAP2 CENPF TEP1 YEATS4 TENM1 STAG2

3.50e-031711786GO:0034399
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE1 SYNE2

3.77e-03111782GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE1 SYNE2

3.77e-03111782GO:0106094
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE1 SYNE2

3.77e-03111782GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE1 SYNE2

3.77e-03111782GO:0034993
DomainRIH_assoc-dom

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754IPR013662
DomainIns145_P3_rec

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754PF08709
DomainRIH_assoc

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754PF08454
DomainRIH_dom

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754IPR000699
DomainIns145_P3_rcpt

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754IPR014821
DomainRyanodine_recept-rel

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754IPR015925
Domain-

RYR3 ITPR1 ITPR2 ITPR3

1.10e-07617541.25.10.30
DomainRYDR_ITPR

RYR3 ITPR1 ITPR2 ITPR3

1.10e-0761754PF01365
DomainInsP3_rcpt-bd

ITPR1 ITPR2 ITPR3

8.09e-0731753IPR000493
DomainMIR

RYR3 ITPR1 ITPR2 ITPR3

1.50e-06101754PF02815
DomainMIR_motif

RYR3 ITPR1 ITPR2 ITPR3

1.50e-06101754IPR016093
DomainMIR

RYR3 ITPR1 ITPR2 ITPR3

1.50e-06101754PS50919
DomainMIR

RYR3 ITPR1 ITPR2 ITPR3

1.50e-06101754SM00472
DomainSpectrin

SYNE1 SPTA1 SPTBN2 SYNE2

5.74e-05231754PF00435
DomainvATP-synt_AC39

ATP6V0D1 ATP6V0D2

8.73e-0521752PF01992
DomainATPase_V0-cplx_dsu

ATP6V0D1 ATP6V0D2

8.73e-0521752IPR016727
DomainATPase_V0-cplx_csu/dsu

ATP6V0D1 ATP6V0D2

8.73e-0521752IPR002843
DomainFERM_central

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

9.32e-05491755IPR019748
DomainFERM_domain

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

9.32e-05491755IPR000299
DomainFERM_1

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

1.03e-04501755PS00660
DomainFERM_2

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

1.03e-04501755PS00661
DomainFERM_3

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

1.03e-04501755PS50057
DomainBand_41_domain

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

1.03e-04501755IPR019749
DomainB41

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

1.03e-04501755SM00295
DomainSpectrin_repeat

SYNE1 SPTA1 SPTBN2 SYNE2

1.47e-04291754IPR002017
DomainSPEC

SYNE1 SPTA1 SPTBN2 SYNE2

2.18e-04321754SM00150
DomainSpectrin/alpha-actinin

SYNE1 SPTA1 SPTBN2 SYNE2

2.18e-04321754IPR018159
DomainCHD_N

CHD4 CHD5

2.60e-0431752IPR012958
DomainCHD_C2

CHD4 CHD5

2.60e-0431752IPR012957
DomainCHDCT2

CHD4 CHD5

2.60e-0431752PF08074
DomainCHDNT

CHD4 CHD5

2.60e-0431752PF08073
DomainDUF1086

CHD4 CHD5

2.60e-0431752IPR009462
DomainDUF1087

CHD4 CHD5

2.60e-0431752IPR009463
DomainDUF1087

CHD4 CHD5

2.60e-0431752PF06465
DomainDUF1086

CHD4 CHD5

2.60e-0431752PF06461
DomainDUF1087

CHD4 CHD5

2.60e-0431752SM01147
DomainDUF1086

CHD4 CHD5

2.60e-0431752SM01146
DomainMyosin_N

MYH1 MYH4 MYH7B

3.39e-04151753PF02736
DomainMyosin_N

MYH1 MYH4 MYH7B

3.39e-04151753IPR004009
DomainMyosin_head_motor_dom

MYH1 MYH4 MYH7B MYO15A

4.29e-04381754IPR001609
DomainMYOSIN_MOTOR

MYH1 MYH4 MYH7B MYO15A

4.29e-04381754PS51456
DomainMyosin_head

MYH1 MYH4 MYH7B MYO15A

4.29e-04381754PF00063
DomainMYSc

MYH1 MYH4 MYH7B MYO15A

4.29e-04381754SM00242
DomainKASH

SYNE1 SYNE2

5.17e-0441752IPR012315
DomainKASH

SYNE1 SYNE2

5.17e-0441752PS51049
DomainKASH

SYNE1 SYNE2

5.17e-0441752SM01249
DomainKASH

SYNE1 SYNE2

5.17e-0441752PF10541
DomainMyosin_tail_1

MYH1 MYH4 MYH7B

5.95e-04181753PF01576
DomainMyosin_tail

MYH1 MYH4 MYH7B

5.95e-04181753IPR002928
DomainMyosin-like_IQ_dom

MYH1 MYH4 MYH7B

7.02e-04191753IPR027401
Domain-

MYH1 MYH4 MYH7B

7.02e-041917534.10.270.10
DomainPH_dom-like

ARHGAP15 SPTBN2 FRMPD1 AFAP1L1 FARP2 JAK1 PTPN13 SBF2 PLD2 PLCH1 PLEKHA8 MAPK8IP2

7.02e-0442617512IPR011993
DomainFERM_M

FRMPD1 FARP2 PTPN13 MYO15A

8.94e-04461754PF00373
DomainQuino_amine_DH_bsu

FSTL4 TEP1 NBAS

1.09e-03221753IPR011044
DomainACTININ_2

SYNE1 SPTBN2 SYNE2

1.25e-03231753PS00020
DomainACTININ_1

SYNE1 SPTBN2 SYNE2

1.25e-03231753PS00019
DomainActinin_actin-bd_CS

SYNE1 SPTBN2 SYNE2

1.25e-03231753IPR001589
DomainChromo_domain

CHD4 CHD5 CHD6

1.42e-03241753IPR023780
DomainChromo

CHD4 CHD5 CHD6

1.79e-03261753PF00385
DomainCHROMO_1

CHD4 CHD5 CHD6

2.23e-03281753PS00598
DomainCHROMO_2

CHD4 CHD5 CHD6

2.23e-03281753PS50013
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

SPTBN2 ITPR1 ITPR2 ITPR3

1.27e-06101274M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

7.05e-0651273M49000
PathwayREACTOME_CGMP_EFFECTS

KCNMB2 PDE2A ITPR1 PRKG1

1.05e-05161274M902
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.40e-0561273M47960
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR3 ITPR1 ITPR2 ITPR3

2.19e-05191274M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3 CD3E

2.19e-05191274M47733
PathwayREACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE

KCNMB2 PDE2A ITPR1 PRKG1

4.05e-05221274M915
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

5.77e-0591273M47852
PathwayREACTOME_CGMP_EFFECTS

PDE2A ITPR1 PRKG1

8.18e-05101273MM15054
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3 RASGRP1

9.39e-05271274M12123
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.12e-04111273M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2 ITPR3

1.12e-04111273M27466
PathwayREACTOME_ION_HOMEOSTASIS

RYR3 ITPR1 ITPR2 ITPR3 ATP1A1

1.22e-04541275M27460
PathwayREACTOME_ION_HOMEOSTASIS

RYR3 ITPR1 ITPR2 ITPR3 ATP1A1

1.22e-04541275MM15202
PathwayREACTOME_PLATELET_HOMEOSTASIS

KCNMB2 PDE2A ITPR1 ITPR2 ITPR3 PRKG1

1.24e-04861276M916
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3 KCNS3

1.86e-04321274MM14983
PathwayREACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE

PDE2A ITPR1 PRKG1

1.91e-04131273MM15015
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.91e-04131273M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.91e-04131273M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.91e-04131273M47751
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

1.91e-04131273MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

3.67e-04161273M26945
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3 KCNS3

5.40e-04421274M791
PathwayREACTOME_PLATELET_HOMEOSTASIS

PDE2A ITPR1 ITPR2 ITPR3 PRKG1

6.08e-04761275MM15051
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2 ITPR3

6.23e-04191273M27423
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2 ITPR3 ANGPTL2

7.03e-04451274M5193
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

7.28e-04201273M47688
PathwaySIG_BCR_SIGNALING_PATHWAY

INPP5D ITPR1 ITPR2 ITPR3

7.65e-04461274M8626
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

8.43e-04211273M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

9.70e-04221273M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

9.70e-04221273M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.11e-03231273M47676
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

INPP5D PTPN13 SBF2 PLEKHA8

1.31e-03531274M662
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

DOC2A STARD13 MYH1 MYH4 MACC1 INTU SET COPA CENPF MYH7B SYNE1 PCDHGA2 SMCHD1 SPTA1 ADAM7 SPTBN2 COQ6 DNAJC18 SYNPO CHD4 PFKM FER1L6 LRPPRC BCAP31 TRIM67 SETSIP STARD9 SCG3 CHD5 SYNE2 TENM1 ATG4C CHD6 EIF2AK4 KIF5A ATP1A1 PLCH1 STAG2

1.07e-1614421813835575683
Pubmed

From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.

RELN CALB2 MAP2 L1CAM SLC1A2

6.96e-0914181516880397
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR3 ITPR1 ITPR2 ITPR3

1.06e-086181423463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR3 ITPR1 ITPR2 ITPR3

1.06e-086181425966694
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR3 ITPR1 ITPR2 ITPR3

1.06e-086181420519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR3 ITPR1 ITPR2 ITPR3

1.06e-086181416844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR3 ITPR1 ITPR2 ITPR3

2.45e-087181411860456
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

MAP2 RPS3A SYNE1 POLE RTN4 SPTBN2 TMEM199 CCDC18 POR DNAJC18 PFKM THOC5 ITPR1 ITPR2 ITPR3 NBAS LRPPRC GTF2E2 BCAP31 PTPN13 INF2 SYNE2 MIB1 TMED10 PLCH1 NPAT

6.55e-0814871812633957083
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

VPS13C STARD9 SRGAP1 CHD5 MIB1 WDR35 TXNDC16 CHD6 EIF2AK4

1.20e-07153181910718198
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2 ITPR3

1.39e-073181310874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2 ITPR3

1.39e-073181320395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2 ITPR3

1.39e-073181317437169
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2 ITPR3

1.39e-073181318547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2 ITPR3

1.39e-073181336350267
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2 ITPR3

1.39e-073181311413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.39e-073181326009177
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2 ITPR3

1.39e-07318131693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2 ITPR3

1.39e-073181323955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2 ITPR3

1.39e-073181331979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2 ITPR3

1.39e-073181324904548
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2 ITPR3

1.39e-07318139858485
Pubmed

Disruption of hippocampal development in vivo by CR-50 mAb against reelin.

RELN CALB2 MAP2

1.39e-07318139223338
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2 ITPR3

1.39e-07318139808793
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2 ITPR3

1.39e-073181318194433
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2 ITPR3

1.39e-073181327777977
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2 ITPR3

1.39e-073181317581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2 ITPR3

1.39e-073181318241669
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2 ITPR3

1.39e-073181319068129
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

1.39e-073181317327232
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2 ITPR3

1.39e-073181316014380
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2 ITPR3

1.39e-073181317890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2 ITPR3

1.39e-073181323983250
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

1.39e-073181320427533
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SIN3B PDE2A CENPF SYNE1 SPTBN2 SYNPO CHD4 SLC1A2 ZBTB1 PPM1H CCDC88C LRPPRC TRIM67 SYNE2 NT5C2 GOLGA8B KIF5A TMED10 PLP1 MAPK8IP2

1.71e-079631812028671696
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NRIP1 NR2C1 RELN PDE2A COPA LONRF1 SYNE1 RHOBTB3 SPTBN2 ZBTB43 SYNPO CHD4 CMYA5 RYR3 JAK1 PTPN13 SCG3 MIB1 CHD6 ANKRD36 KIF5A PLP1 MAPK8IP2

2.69e-0712851812335914814
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

COPA CENPF VPS13C SYNE1 POLE RTN4 TMEM199 POR PFKM ITPR1 ITPR2 ITPR3 NBAS LRPPRC BCAP31 INF2 TMLHE SYNE2 MIB1 SECISBP2 ATP1A1 TMED10 HERC1 APOL2 RHOT1

2.81e-0714961812532877691
Pubmed

COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.

RELN CALB2 MAP2 L1CAM

3.40e-0712181417021036
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

CALB2 ITPR1 ITPR2 ITPR3 TET1

3.88e-0729181532123907
Pubmed

Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.

RELN CALB2 MAP2 L1CAM

4.89e-0713181412091317
Pubmed

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.

COPA RTN4 TMEM199 POR ITPR2 ITPR3 NBAS BCAP31 INF2 SYNE2 MIB1

5.43e-072991811137931956
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2 ITPR3

5.52e-074181325215520
Pubmed

BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex.

RELN CALB2 MAP2

5.52e-07418139728912
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

5.52e-074181311163362
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2 ITPR3

5.52e-074181321424589
Pubmed

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex.

RELN CALB2 L1CAM

5.52e-07418139698328
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2 ITPR3

5.52e-074181328615414
Pubmed

The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons.

RELN CALB2 MAP2

5.52e-07418137748558
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2 ITPR3

5.52e-074181310828023
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2 ITPR3

5.52e-074181328419336
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2 ITPR3

5.52e-074181335494252
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2 ITPR3 PLP1

6.82e-0714181434630045
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

SIN3B RTN4 TMEM199 POR ITPR2 ITPR3 NBAS BCAP31 INF2 SYNE2 APOL2 PLEKHA8

7.20e-073751811232788342
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

LRRC8C RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 INF2 SYNE2 TMED10 PLEKHA8

1.20e-064681811331056421
Pubmed

Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.

RELN CALB2 L1CAM

1.38e-065181312451131
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2 ITPR3

1.38e-065181321568942
Pubmed

Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.

RELN MAP2 ITPR1

1.38e-065181319167437
Pubmed

C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.

RELN CALB2 MAP2

1.38e-065181318506028
Pubmed

Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract.

RELN CALB2 MAP2

1.38e-06518139742149
Pubmed

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.

MYH1 RELN MYOM1 MYH7B COQ6 PFKM CMYA5 CPT1B FSIP2 LRPPRC ATP1A1

1.47e-063311811129199018
Pubmed

The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.

CALB2 MAP2 L1CAM MAPK8IP2

1.60e-0617181415572149
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PDE2A COPA MAP2 RPS3A SYNE1 SPTA1 RTN4 SPTBN2 L1CAM POR SYNPO PFKM SLC1A2 ITPR2 LRPPRC GTF2E2 ATP6V0D1 INF2 ATP1A1 PLCH1 PLP1 MAPK8IP2 RHOT1

1.70e-0614311812337142655
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NRIP1 SIN3B NR2C1 GAPVD1 CENPF ZGRF1 CHD4 ZBTB1 PTPN13 TET1 CHD6 NPAT

2.23e-064181811234709266
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

SET COPA MAP2 CENPF RPS3A SMCHD1 RTN4 SPTBN2 PTPN23 SYNE2 STAG2 PLIN3 RHOT1

2.37e-064981811336634849
Pubmed

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.

POLE TEP1 EIF2AK4 CSMD1

2.59e-0619181414671302
Pubmed

Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons.

RELN CALB2 MAP2

2.74e-066181315617678
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

2.74e-066181321762810
Pubmed

Overstimulation of NMDA receptors impairs early brain development in vivo.

MAP2 L1CAM SLC1A2

2.74e-066181322606296
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

SYNE1 SPTA1 L1CAM CCDC168 RYR3 FSIP2 PTPN13 SRGAP1

3.02e-06168181830631154
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2 ITPR3

4.78e-067181322495310
Pubmed

Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages.

RELN CALB2 MAP2

4.78e-067181319710317
Pubmed

Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.

RELN MAP2 ITPR1

4.78e-06718138863127
Pubmed

The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex.

RELN CALB2 MAP2

4.78e-067181310648716
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

MACC1 SPTA1 SAMSN1 SRGAP1 MYO15A

6.33e-0650181519807924
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SET COPA RTN4 SPTBN2 CD109 QTRT2 SYNPO CHD4 PFKM PDCD4 ITPR1 ITPR2 ITPR3 NBAS LRPPRC ATP6V0D1 INF2 SYNE2 ATP1A1 TMED10 STAG2 PLIN3

6.52e-0614401812230833792
Pubmed

Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.

RELN CALB2 MAP2 GOLGA8B

6.95e-0624181426060116
Pubmed

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.

RELN CALB2 MAP2

7.62e-068181324036464
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR3 ITPR2 ITPR3

7.62e-068181319033399
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

GAPVD1 VPS13C RTN4 TMEM199 POR NHLRC2 ITPR1 ITPR3 NBAS BCAP31 INF2 SYNE2 PLIN3

9.77e-065681811337774976
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

UBR1 SIN3B SET COPA RTN4 QTRT2 PTPN23 SYNPO CHD4 PFKM LRPPRC BCAP31 ATP6V0D1 INF2 SYNE2 NFKBIE NUDCD1 ATP1A1 TMED10 APOL2 PLIN3

9.89e-0613671812132687490
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

COPA SPTBN2 CCDC18 POR PTPN23 CTDNEP1 PPM1H ITPR1 ITPR2 ITPR3 PTPN13 YEATS4 PTPRE SBF2 SYNE2 MIB1 EIF2AK4 HERC1

1.03e-0510491811827880917
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NRIP1 INTU MAP2 VPS13C FRMPD1 SYNPO TEP1 PPM1H FARP2 DOCK5 LRPPRC PTPN13 PTPRE GPR137C INF2 TGFBRAP1 SBF2 NT5C2 CHD6 EIF2AK4 CSMD1 STAG2

1.10e-0514891812228611215
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

RELN MAP2 ITPR1

1.14e-059181331491533
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2 ITPR3

1.14e-059181325737585
Pubmed

Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice.

RELN CALB2 MAP2

1.14e-059181316571605
Pubmed

Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis.

RELN CALB2 MAP2

1.14e-059181322898830
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

MYH4 COPA SMCHD1 ITPR3 DOCK5 NBAS EIF2AK4 ATP1A1

1.17e-05202181833005030
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

NRIP1 SET MYOM1 SYNE1 LAMA4 CHD4 CMYA5 LRPPRC SYNE2 TRIM55 ATP1A1 STAG2

1.28e-054971811223414517
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

RTN4 L1CAM CD109 POR PFKM JAK1 BCAP31 ATP6V0D1 NT5C2 ATP1A1 TMED10

1.46e-054221811127342126
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

VPS13C RTN4 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 PTPN13 INF2 SYNE2 TENM1

1.47e-055041811234432599
Pubmed

Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.

MAP2 L1CAM PLP1

1.62e-0510181324917275
Pubmed

The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.

L1CAM KIF5A PLP1

1.62e-0510181317420921
Pubmed

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.

MYH1 MYH4 MYOM1

1.62e-0510181319506036
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SEMA3F LRRC8C NPR3 COPA RTN4 L1CAM CD109 FSTL4 LAMA4 DNAJC18 ITPR1 ITPR2 FAT1 BCAP31 TXNDC16 ATP1A1 TMED10 APOL2 PLIN3

1.80e-0512011811935696571
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GAPVD1 SET COPA CENPF RPS3A VPS13C SYNE1 POLE SMCHD1 RTN4 POR CHD4 PFKM CMYA5 LRPPRC BCAP31 MROH8 ATP6V0D1 STARD9 ATP1A1 STAG2

1.83e-0514251812130948266
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DOC2A SEMA3F PDE2A LONRF1 POLE L1CAM TEP1 CTDNEP1 ITPR2 ITPR3 CCDC88C FAT1 INF2 BTBD7 CHD5 SBF2 HMGXB3 HERC1

2.06e-0511051811835748872
Pubmed

Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.

MYH1 MYH4 MYOM1

2.22e-0511181318310078
Pubmed

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.

RELN CALB2 MAP2

2.22e-0511181311163262
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2 ITPR3

2.22e-0511181327514653
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

PDE2A SET MAP2 RPS3A SPTA1 POR PFKM SLC1A2 ITPR1 ATP6V0D1 PTPRE ATP1A1 PLP1

2.49e-056211811322794259
Pubmed

Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.

SEMA3F RELN CALB2 MAP2

2.58e-0533181418199763
InteractionTMT1A interactions

SYNE1 RTN4 TMEM199 POR CCDC168 ITPR1 ITPR2 ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 MIB1 ATP1A1 TMED10

1.21e-0735917716int:TMT1A
InteractionHSD17B11 interactions

COPA SYNE1 RTN4 TMEM199 POR NHLRC2 ITPR1 ITPR2 ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 MIB1 ATP1A1

3.69e-0739017716int:HSD17B11
InteractionBCAP31 interactions

MYH1 MYH4 COPA ARHGAP15 CENPF MYH7B RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS LRPPRC BCAP31 TRIM67 INF2 SYNE2 APOL2

4.50e-0755417719int:BCAP31
InteractionGJD3 interactions

COPA VPS13C SYNE1 RTN4 SPTBN2 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 PTPN13 INF2 SYNE2 ATP1A1 APOL2

5.64e-0745417717int:GJD3
InteractionDHFR2 interactions

TMEM199 CD109 POR PFKM SERPINA6 ITPR2 ITPR3 NBAS BCAP31 LIPH TXNDC16 ATP1A1 HERC1

1.74e-0628917713int:DHFR2
InteractionLMAN1 interactions

COPA VPS13C SPTBN2 TMEM199 POR DNAJC18 NHLRC2 PPM1H ITPR2 ITPR3 LRPPRC BCAP31 TRIM67 SYNE2 ATP1A1 TMED10

1.86e-0644117716int:LMAN1
InteractionSEC62 interactions

PDE2A MYH7B SYNE1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 MIB1 ATP1A1 TMED10

2.48e-0650617717int:SEC62
InteractionDERL1 interactions

COPA SMCHD1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS LRPPRC BCAP31 TRIM67 INF2 SYNE2 ATP1A1 APOL2

2.62e-0645317716int:DERL1
InteractionELOVL5 interactions

COPA RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 JAK1 NBAS BCAP31 TRIM67 INF2 SYNE2 ATP1A1

4.31e-0636417714int:ELOVL5
InteractionIRAG1 interactions

ITPR1 ITPR2 ITPR3 PRKG1

5.37e-06141774int:IRAG1
InteractionSSR1 interactions

RPS3A SYNE1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 ATP6V0D1 TRIM67 INF2 SYNE2 TMED10

1.18e-0545317715int:SSR1
InteractionSEC61B interactions

COPA RPS3A SYNE1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS FREM2 BCAP31 INF2 SYNE2 MIB1 TXNDC16 ATP1A1 TMED10 APOL2 PLEKHA8

1.31e-0576317720int:SEC61B
InteractionLNPK interactions

COPA SYNE1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 INF2 SYNE2 PLIN3

1.61e-0535517713int:LNPK
InteractionCHRNA3 interactions

TMPPE ITPR2 ITPR3 MIB1 APOL2

2.23e-05391775int:CHRNA3
InteractionERGIC1 interactions

PDE2A COPA SPTBN2 TMEM199 ITPR2 ITPR3 BCAP31 TRIM67 SYNE2 ATP1A1 APOL2

2.27e-0526417711int:ERGIC1
InteractionREEP5 interactions

TMPPE COPA RTN4 TMEM199 POR ITPR2 ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 PLP1

2.56e-0537117713int:REEP5
InteractionSTX4 interactions

COPA CENPF SYNE1 RTN4 TMEM199 POR ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 ATP1A1 PLP1

2.66e-0542817714int:STX4
InteractionDNAJC25 interactions

SYNE1 RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 NBAS BCAP31 INF2 SYNE2

4.43e-0528417711int:DNAJC25
InteractionUCN3 interactions

CD109 FREM2 FAT1 HERC1

4.47e-05231774int:UCN3
InteractionCTDNEP1 interactions

POR CTDNEP1 ITPR1 ITPR2 ITPR3 SYNE2

5.14e-05751776int:CTDNEP1
InteractionEMD interactions

COPA SYNE1 SPTA1 RTN4 TMEM199 POR CHD4 PDCD4 ITPR1 ITPR2 ITPR3 NBAS BCAP31 TRIM67 INF2 SYNE2 MIB1 ATP1A1 TMED10

6.86e-0578917719int:EMD
InteractionATP2A1 interactions

MYH1 COPA RTN4 TMEM199 POR ITPR1 ITPR2 ITPR3 BCAP31 INF2 SYNE2 APOL2 MUL1

9.74e-0542317713int:ATP2A1
InteractionATP6V0A4 interactions

TMEM199 PFKM ATP6V0D1 ATP6V0D2

9.99e-05281774int:ATP6V0A4
InteractionTMPRSS4 interactions

TMEM199 POR PFKM ITPR1 ITPR3 FAT1 BCAP31 INF2 SYNE2 MIB1 RHOT1

1.09e-0431417711int:TMPRSS4
InteractionHDAC1 interactions

MYH1 NRIP1 SIN3B NR2C1 MYH4 GAPVD1 CENPF ZGRF1 ZBTB43 CHD4 SAMSN1 ZBTB1 THOC5 LRPPRC PTPN13 TRIM67 CHD5 SYNE2 TET1 PRKG1 NUDCD1 STAG2 NPAT

1.11e-04110817723int:HDAC1
InteractionITGA5 interactions

RTN4 L1CAM CDH23 BCAP31 TRIM67 TXNDC16 ATP1A1

1.32e-041271777int:ITGA5
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2 ITPR3

3.39e-0731273297
GeneFamilyMyosin heavy chains

MYH1 MYH4 MYH7B MYH16

2.98e-061512741098
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMPD1 FARP2 JAK1 PTPN13 MYO15A

2.60e-055012751293
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

2.91e-04412721252
GeneFamilyEF-hand domain containing

CALB2 SPTA1 FSTL4 RYR3 RASGRP1 PLCH1 RHOT1

9.09e-042191277863
GeneFamilyEF-hand domain containing|Spectrins

SPTA1 SPTBN2

1.00e-03712721113
GeneFamilyPHD finger proteins|NuRD complex

CHD4 CHD5

3.09e-031212721305
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGAP15 SPTBN2 AFAP1L1 FARP2 SBF2 PLEKHA8

3.36e-032061276682
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

CMYA5 RYR3 DOCK5 FAT1 PTPN13 SRGAP1 SBF2 MIB1 ANKRD36 PRKG1

1.92e-0621217710M39221
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH1 RELN SPTA1 TEX11 RYR3 FREM2 FAT1 TENM1 KIF5A CSMD1 PLCH1 MYO15A ANO3

7.96e-13184182132cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH1 RELN SPTA1 TEX11 RYR3 FREM2 FAT1 TENM1 KIF5A CSMD1 PLCH1 MYO15A ANO3

7.96e-13184182132b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH1 RELN SPTA1 TEX11 RYR3 FREM2 FAT1 TENM1 KIF5A CSMD1 PLCH1 MYO15A ANO3

7.96e-1318418213ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellControl-T_cells-CD4+_T_cells|Control / group, cell type (main and fine annotations)

LRRC8C ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 PDCD4 CCDC88C RASGRP1 SYNE2

6.48e-09190182100733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRRC8C RPS3A SMCHD1 PDCD4 RASGRP1 CD3E PTPN13 SYNE2 GOLGA8B ANKRD36

8.73e-09196182104a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

LRRC8C ARHGAP15 TTC39C INPP5D SMCHD1 PDCD4 CCDC88C RASGRP1 SYNE2

8.13e-081871829f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 MACC1 SPTBN2 L1CAM FSTL4 SAMSN1 CCDC88C RASGRP1 PTPN13

8.90e-0818918293a295c215b5c18e7c673f92b7af5be523421682c
ToppCellCOVID-19-T_cells-CD4+_T_cells|COVID-19 / group, cell type (main and fine annotations)

LRRC8C ARHGAP15 TTC39C INPP5D SMCHD1 CCDC88C RASGRP1 CD3E SYNE2

9.74e-0819118290646cca78e24aeb6baa9934d3c439b797c567997
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

ARHGAP15 CENPF TTC39C INPP5D SMCHD1 CCDC88C RASGRP1 CD3E SYNE2

9.74e-0819118297f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ARHGAP15 TTC39C SMCHD1 ANKRD36C RASGRP1 CD3E PTPN13 SYNE2 GOLGA8B

1.16e-07195182922191d361af136942508f1553ff41a626ed982ad
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

LRRC8C ARHGAP15 RPS3A TTC39C RASGRP1 CD3E INF2 SYNE2 GOLGA8B

1.27e-071971829c842d169dfce9af3ed7c01dc7e940c0bdd21388c
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SMCHD1 ANKRD36C TEX11 SYNE2 TENM1 GOLGA8B ANKRD36 HERC1

1.27e-07197182957ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-type_I_NK_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 RHOBTB3 ANKRD36C ZBTB1 JAK1 CCDC88C CD3E SYNE2 GOLGA8B

1.32e-07198182958d805e827299292750b09c6283fdbe406b75f79
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 PDCD4 CCDC88C RASGRP1 TENM1

1.44e-072001829510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH1 MYH4 MACC1 MYOM1 CMYA5 CPT1B TRIM55 PLCH1

4.50e-071671828d78356bf0c473816dbabaee51984940bd822f84e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP15 ANKRD36C IGSF22 CD3E PTPN13 SYNE2 MIB1 ANKRD36

4.50e-07167182883969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

INPP5D CMYA5 PPM1H ITPR2 FARP2 CHD6 CSMD1 SLC38A3

4.71e-0716818288072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellControl-T_cells-Tregs|Control / group, cell type (main and fine annotations)

ARHGAP15 TTC39C INPP5D SAMSN1 CCDC88C RASGRP1 CD3E SYNE2

4.92e-071691828e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ARHGAP15 TTC39C SMCHD1 SAMSN1 CD3E PTPN13 SYNE2 ANKRD36

5.38e-07171182861318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TCTE1 MAP2 CD109 AQP7B SYNPO HIF3A AQP7 AFAP1L1

6.14e-0717418283d4c05ea5719ca65e85d1f15198453034791087c
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RELN PDE2A LAMA4 DNAJC18 HIF3A AFAP1L1 DOCK5 PRKG1

7.29e-071781828ad3de3e03a401dac64431a541899445262246347
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGA2 ADAM7 SPTBN2 FSTL4 ITPR1 MEP1B CHD5 MAPK8IP2

7.61e-071791828a3922476f33d2e4137a12dbda21a1703dff79684
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN L1CAM SYNDIG1 PTPN13 SCG3 CHD5 CSMD1 PLP1

7.93e-071801828dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN L1CAM SYNDIG1 PTPN13 SCG3 CHD5 CSMD1 PLP1

7.93e-071801828d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCellCOPD-Lymphoid-T_Regulatory|World / Disease state, Lineage and Cell class

ARHGAP15 SMCHD1 LAIR2 CCDC88C RASGRP1 CD3E SYNE2 GOLGA8B

7.93e-07180182851a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RTN4 SYNPO SLC1A2 ITPR1 RASGRP1 INF2 ATP1A1 ANO3

1.02e-06186182856c139e679d640ea901ead657a8e8887e0fca098
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.02e-0618618289d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.02e-061861828bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3F RELN PDE2A NPR3 LAMA4 CPT1B ANGPTL2 KCNS3

1.02e-06186182837860daeecd6d412bd3797f30496a56da667fbd1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3F RELN PDE2A NPR3 LAMA4 CPT1B ANGPTL2 KCNS3

1.02e-06186182860830822d3de3147816693404fd03392e04c2b8e
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3F RELN PDE2A NPR3 LAMA4 CPT1B ANGPTL2 KCNS3

1.02e-061861828baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.02e-061861828924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCellPND07-28-samps-Mesenchymal-Mesenchymal_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TCTE1 MYH1 MAP2 CD109 SYNPO RASGRP1 AGMAT

1.10e-0613018276c6a8b77af08b30b424d4f5def37315d3c6e28b2
ToppCellPND07-28-samps-Mesenchymal-Mesenchymal_fibroblast-mesenchymal_B|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TCTE1 MYH1 MAP2 CD109 SYNPO RASGRP1 AGMAT

1.10e-0613018270706092f6b466585b3b4808b3b982a122d66cfcf
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

RELN PDE2A LAMA4 DNAJC18 HIF3A AFAP1L1 DOCK5 PTPRE

1.10e-061881828c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellASK452-Immune-T_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

TTC39C ANKRD36C PDCD4 RASGRP1 CD3E SYNE2 ANKRD36 HERC1

1.15e-061891828f5dc500f77f04a110dd4a65cf4c03068a495dbdb
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP2 L1CAM TRIM67 SCG3 CHD5 SYT14 KIF5A MAPK8IP2

1.15e-061891828cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RELN PDE2A LAMA4 DNAJC18 HIF3A AFAP1L1 DOCK5 PTPRE

1.19e-0619018286e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.24e-0619118285a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellCOVID-19-lung-CD4+_Treg|lung / Disease (COVID-19 only), tissue and cell type

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.24e-06191182873ea3078c1f55cd47e4d99e77b3ce4ff17549d49
ToppCellCOVID-19-lung-CD8+_T_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGAP15 TTC39C INPP5D SAMSN1 PDCD4 CCDC88C RASGRP1 CD3E

1.24e-061911828543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STARD13 CCDC60 ARHGAP15 L1CAM LAMA4 ITPR3 SCG3 PLP1

1.29e-0619218283fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCellCOPD-Lymphoid|COPD / Disease state, Lineage and Cell class

ARHGAP15 SYNE1 INPP5D SMCHD1 CCDC88C RASGRP1 CD3E SYNE2

1.29e-061921828064fefb8212fadab0ff441f4bf643559b7fdb25d
ToppCellIPF-Lymphoid-T|World / Disease state, Lineage and Cell class

LRRC8C ARHGAP15 TTC39C INPP5D SMCHD1 CCDC88C CD3E SYNE2

1.29e-061921828b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GARNL3 MAP2 L1CAM TRIM67 SCG3 CHD5 SYT14 MAPK8IP2

1.34e-061931828a189d46c39067b717509cd144e0225cc93d7731d
ToppCellCOVID-19-lung-CD4+_T_cells_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGAP15 TTC39C INPP5D SMCHD1 SAMSN1 CCDC88C RASGRP1 CD3E

1.34e-061931828326fd2ce2c4b51e5a38f2a7a09f22f8f0e92735a
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SMCHD1 ANKRD36C TEX11 SYNE2 GOLGA8B ANKRD36 HERC1

1.34e-0619318289337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP1 VPS13C PDCD4 PPM1H ITPR2 RASGRP1 CD3E PLP1

1.34e-061931828a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHOBTB3 RTN4 SPTBN2 L1CAM FSTL4 RASGRP1 KL PTPN13

1.34e-061931828d994b2f2707877288f88cab7cd6002ef91962c50
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 RHOBTB3 SPTBN2 SAMSN1 CMYA5 RASGRP1 PTPN13 ATP1A1

1.39e-06194182869bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellCOVID-19-lung-CD4+_T_cells_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

ARHGAP15 TTC39C INPP5D SMCHD1 CCDC88C RASGRP1 CD3E SYNE2

1.39e-0619418282a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCell18-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

PDE2A L1CAM TRIM67 SCG3 CHD5 KIF5A PLP1 MAPK8IP2

1.39e-061941828d3c90e1f1228f8ba0ba56105c6cf4f302c388f28
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRC8C ARHGAP15 INPP5D SMCHD1 RASGRP1 CD3E SYNE2 STAG2

1.45e-061951828ffb40486f8097b2c08e8f3b3685d0b8cb8d1bc66
ToppCellnucseq-Immune-Lymphocytic_T/NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRC8C ARHGAP15 INPP5D SMCHD1 RASGRP1 CD3E SYNE2 STAG2

1.45e-061951828b8124e8a23e6d37b40023608674e67285c6ffe84
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHOBTB3 RTN4 SPTBN2 FSTL4 KL PTPN13 PRKG1 ATP1A1

1.45e-0619518283f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RHOBTB3 RTN4 SPTBN2 L1CAM FSTL4 RASGRP1 KL PTPN13

1.45e-061951828e94bac6a5c788ee160d7feaf2a3c512a3691f995
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 LAIR2 ANKRD36C CCDC88C RASGRP1 CD3E SYNE2 TENM1

1.45e-06195182814a6466524c22920daa622fbc710daf1defb46c3
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

PDE2A INPP5D SMCHD1 CD109 SYNPO HIF3A AFAP1L1 PTPRE

1.45e-061951828a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMCHD1 ANKRD36C CCDC88C RASGRP1 CD3E SYNE2 GOLGA8B ANKRD36

1.45e-061951828ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STARD13 CCDC60 ARHGAP15 L1CAM LAMA4 ITPR3 SCG3 PLP1

1.50e-0619618289afd0a7135028a446f06bb68f334e79b8f171b45
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE2A INPP5D CD109 HIF3A RYR3 AFAP1L1 PTPRE STARD9

1.50e-0619618288ad8efb631164b46f0c082572270188e5ead20bf
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA3F SYNE1 FSTL4 HIF3A AFAP1L1 STARD9 SYNE2 PRKG1

1.50e-06196182849cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

INTU ARHGAP15 SYNE1 LAIR2 RASGRP1 CD3E SYNE2 GOLGA8B

1.50e-061961828a9157809122e6fc5783a291522f103bef30943e4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE2A INPP5D CD109 HIF3A RYR3 AFAP1L1 PTPRE STARD9

1.50e-0619618289606ea7e42f707e69ea891b3521037613b9675f5
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

SEMA3F SYNE1 FSTL4 HIF3A AFAP1L1 STARD9 SYNE2 PRKG1

1.50e-0619618284ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RELN PDE2A INPP5D CD109 HIF3A AFAP1L1 PTPRE STARD9

1.50e-061961828d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 LAIR2 ANKRD36C CCDC88C RASGRP1 CD3E SYNE2 TENM1

1.56e-06197182835004d4728d33f15cc3be99a073b1ea965365c32
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 RELN L1CAM STARD9 TENM1 KIF5A MYO15A PLP1

1.56e-061971828e239caae24f40564a24ad909754f5436f767ccdb
ToppCellSevere-Lymphoid-T-CCR7+_T|Severe / Condition, Lineage, Cell class and cell subclass

ARHGAP15 RPS3A SYNE1 TTC39C PDCD4 RASGRP1 CD3E SYNE2

1.56e-0619718280489e0b08f3c3ef90b166ea2f26a0b2b12bd2077
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GARNL3 MAP2 L1CAM TRIM67 SCG3 SYT14 KIF5A MAPK8IP2

1.56e-06197182827c044833e471a312a572e0b1c83e4bc8a36e896
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP15 SYNE1 ANKRD36C RASGRP1 CD3E SYNE2 TENM1 GOLGA8B

1.56e-06197182859b1fb93a39dcf8c994d2b7dc2906dae74c57527
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYOM1 GIMD1 SYNE1 LAMA4 CDH23 HIF3A STARD9 PRKG1

1.56e-061971828ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP2 L1CAM TRIM67 SCG3 CHD5 SYT14 KIF5A MAPK8IP2

1.62e-06198182850504a3871f76d6a5b439a56450d7770f4501eb0
ToppCellSepsis-URO-Lymphocyte-T/NK-CD4+_CTL|URO / Disease, condition lineage and cell class

SYNE1 LAIR2 CCDC88C RASGRP1 CD3E SYNE2 GOLGA8B ANKRD36

1.62e-061981828c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 ANKRD36C ZBTB1 JAK1 CCDC88C CD3E SYNE2 GOLGA8B

1.62e-06198182834c564ece9a2b94dcf646e3c95b5be9c5ecfaafe
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SEMA3F PDE2A INPP5D CD109 SYNPO HIF3A AFAP1L1 STARD9

1.62e-0619818288689090bce9ab6e8f122426a404037e572c6713b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP15 SYNE1 ANKRD36C PDCD4 RASGRP1 CD3E SYNE2 GOLGA8B

1.62e-061981828a3bd099ef0e606c2da690a6fcf6f79e9360c9c9f
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GARNL3 MAP2 L1CAM SCG3 CHD5 SYT14 KIF5A MAPK8IP2

1.68e-061991828ce8dbfd969b3b9c08e1c57c2bfd899818e878731
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

SEMA3F NPR3 CD109 HIF3A AFAP1L1 SYNE2 MIB1 CSMD1

1.68e-061991828793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SMCHD1 ANKRD36C SYNE2 TENM1 GOLGA8B ANKRD36 HERC1

1.68e-061991828f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellhealthy_donor-Lymphocytic|healthy_donor / Disease condition, Lineage, Cell class and subclass

SYNE1 JAK1 CCDC88C RASGRP1 CD3E SYNE2 GOLGA8B ANKRD36

1.68e-0619918282841e16d54acd344ba454f024e285c28abc37319
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 TTC39C ZBTB1 PDCD4 RASGRP1 CD3E SYNE2 GOLGA8B

1.68e-061991828cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellSepsis-URO-Lymphocyte-T/NK-CD4+_Tem|URO / Disease, condition lineage and cell class

ARHGAP15 SYNE1 TTC39C CCDC168 PDCD4 CD3E SYNE2 GOLGA8B

1.75e-0620018288b7bfe6411de9528603481f6e5612cbbb8471cf6
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

GARNL3 RHOBTB3 ANKRD36C CMYA5 PPM1H SRGAP1 SBF2 TET1

1.75e-062001828682960e28542a3d6c119047cd0131941932cfdea
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-062001828dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MYOM1 SYNE1 ARMC9 ITPR1 FAT1 KCNS3 PRKG1 CSMD1

1.75e-062001828c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

PDE2A CALB2 SYNE1 L1CAM PFKM SLC1A2 ATP6V0D1 SCG3

1.75e-06200182844bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-06200182821bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP15 TTC39C INPP5D SAMSN1 PDCD4 CCDC88C RASGRP1 CD3E

1.75e-06200182802c4169a23e5aaa0d4bfc78b51ba19ce8157dc3e
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-06200182833036d21c1c82109284473a515c4f890b33fdd5c
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-062001828a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-0620018283bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 ARHGAP15 INPP5D SYNDIG1 SAMSN1 ITPR2 PTPRE SRGAP1

1.75e-062001828a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC60 CALB2 ARHGAP15 RHOBTB3 SAMSN1 PPM1H RYR3

2.38e-061461827f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC60 CALB2 ARHGAP15 RHOBTB3 SAMSN1 PPM1H RYR3

3.86e-061571827ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN SPTA1 LAMA4 DNAJC18 AFAP1L1 DOCK5 PTPRE

4.56e-061611827fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN SPTA1 LAMA4 DNAJC18 AFAP1L1 DOCK5 PTPRE

4.56e-061611827c53c461fc721a7960cef86662f49e2a495520701
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN SPTA1 LAMA4 DNAJC18 AFAP1L1 DOCK5 PTPRE

4.75e-0616218272ac02523348660e514d464f8f2434ee0c312d784
ToppCellfacs-Kidney-nan-3m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP15 ZGRF1 PDCD4 RYR3 ITPR3 RASGRP1 CD3E

5.35e-061651827ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

RELN PDE2A LAMA4 AFAP1L1 DOCK5 PTPRE PRKG1

5.80e-06167182797d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
DiseaseInherited neuropathies

SPTBN2 L1CAM ITPR1 KIF5A PLP1

3.96e-06401765C0598589
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.43e-05101763DOID:0080326 (implicated_via_orthology)
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

3.54e-0521762C1140716
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

3.54e-0521762C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

3.54e-0521762C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

3.54e-0521762C0995195
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2 ITPR3

4.41e-05121763DOID:1441 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH1 MYH4 MYH7B

4.41e-05121763DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH1 MYH4 MYH7B

4.41e-05121763DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH1 MYH4 MYH7B

5.71e-05131763DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH1 MYH4 MYH7B

9.00e-05151763DOID:0050646 (implicated_via_orthology)
Diseaseunipolar depression, age at onset

LRRC8C INTU ARHGAP15 FAT1

9.45e-05401764EFO_0003761, EFO_0004847
Diseasebitter alcoholic beverage consumption measurement

RELN ARHGAP15 LRPPRC SYT14 ANKRD36 CSMD1

1.52e-041331766EFO_0010092
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

2.11e-0441762cv:CN293514
Diseasesucrose liking measurement

RELN SYNDIG1 GOLGA8B

2.21e-04201763EFO_0010157
DiseaseImmunologic Deficiency Syndromes

NBAS RASGRP1 CD3E

3.38e-04231763C0021051
Diseaseinsomnia measurement

KCNMB2 SEMA3F PDE2A MAP2 ITPR3 RASGRP1 LRPPRC SYT14 NT5C2 PLCH1

3.49e-0444317610EFO_0007876
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

3.50e-0451762C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

3.50e-0451762C0410190
Diseasenephrotic syndrome (implicated_via_orthology)

GAPVD1 COQ6 FAT1

3.85e-04241763DOID:1184 (implicated_via_orthology)
Diseasedisease progression measurement

HORMAD2 CDH23 RYR3 HERC1

4.90e-04611764EFO_0008336
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

5.22e-0461762cv:C0410189
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

5.22e-0461762C0410189
Diseasehydrocephalus (is_implicated_in)

L1CAM CCDC88C

5.22e-0461762DOID:10908 (is_implicated_in)
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

7.28e-0471762C0751337
Diseasecolorectal cancer (is_implicated_in)

POLE CHD4 JAK1 FAT1 PTPN13

8.12e-041211765DOID:9256 (is_implicated_in)
Diseasecardiomyopathy (implicated_via_orthology)

DOC2A MYH1 MYH4 MYH7B

8.71e-04711764DOID:0050700 (implicated_via_orthology)
DiseaseEndometrial Carcinoma

SEMA3F NRIP1 POLE CHD4

9.17e-04721764C0476089
Diseaseholoprosencephaly (is_implicated_in)

PLCH1 STAG2

9.67e-0481762DOID:4621 (is_implicated_in)
DiseaseSpinocerebellar Ataxia Type 2

SPTBN2 CCDC88C SYT14

1.09e-03341763C0752121
DiseaseSpinocerebellar Ataxia Type 1

SPTBN2 CCDC88C SYT14

1.09e-03341763C0752120
DiseaseSpinocerebellar Ataxia Type 5

SPTBN2 CCDC88C SYT14

1.09e-03341763C0752123
DiseaseSpinocerebellar Ataxia Type 7

SPTBN2 CCDC88C SYT14

1.09e-03341763C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

SPTBN2 CCDC88C SYT14

1.09e-03341763C0752124
DiseaseAtaxia, Spinocerebellar

SPTBN2 CCDC88C SYT14

1.09e-03341763C0087012
DiseaseSpinocerebellar Ataxia Type 4

SPTBN2 CCDC88C SYT14

1.19e-03351763C0752122
DiseaseFocal Segmental Glomerulosclerosis, Not Otherwise Specified

SYNPO INF2

1.24e-0391762C4049702
Disease6-bromotryptophan measurement

GPR137C TXNDC16

1.24e-0391762EFO_0800099
Diseaseuterine fibroid

SYNE1 CD109 TEX11 ITPR1 DOCK5 CSMD1

1.28e-031991766EFO_0000731
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH1 MYH4 CENPF MYH7B

1.36e-03801764DOID:12930 (implicated_via_orthology)
Diseasesensory perception of sweet taste

KCNMB2 ARHGAP15 PABPC4L ANO3

1.49e-03821764GO_0050916
DiseaseIntellectual Disability

SET SYNE1 PTPN23 ARMC9 SLC1A2 NT5C2 KIF5A ATP1A1 STAG2

1.52e-034471769C3714756
DiseaseMoyamoya disease

HORMAD2 FSTL4 SBF2

1.75e-03401763MONDO_0016820
DiseaseCalcium channel blocker use measurement

NPR3 NHLRC2 LRPPRC FAT1 SBF2 NT5C2

1.81e-032131766EFO_0009930
DiseaseThyroid preparation use measurement

HORMAD2 SLC1A2 JAK1 RASGRP1 ATP6V0D1 PLIN3

1.98e-032171766EFO_0009933
Diseasediabetic nephropathy

RYR3 ITPR1 JAK1 IGSF22 KL

2.10e-031501765EFO_0000401
Diseasesystemic lupus erythematosus (implicated_via_orthology)

INPP5D JAK1 RASGRP1

2.16e-03431763DOID:9074 (implicated_via_orthology)
DiseaseUterine leiomyoma

SYNE1 TEX11 ITPR1 NPAT

2.18e-03911764HP_0000131
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

2.24e-03121762DOID:11726 (implicated_via_orthology)
Diseasemotor neuron disease (implicated_via_orthology)

KIF5A RHOT1

2.24e-03121762DOID:231 (implicated_via_orthology)
DiseaseBipolar Disorder

RELN MAP2 SYNE1 SLC1A2 ITPR1 RASGRP1 STARD9 ATP1A1 CSMD1

2.36e-034771769C0005586
DiseaseSchizophrenia

NRIP1 RELN RTN4 SPTBN2 CHD4 CMYA5 SLC1A2 TET1 KCNS3 CSMD1 APOL2 PLP1 NPAS4

2.56e-0388317613C0036341
DiseaseAmino Acid Metabolism, Inherited Disorders

SECISBP2 EIF2AK4

2.64e-03131762C0750905
DiseaseAmino Acid Metabolism, Inborn Errors

SECISBP2 EIF2AK4

2.64e-03131762C0002514
Diseasealcohol use disorder measurement, alcohol consumption measurement

ARHGAP15 LRPPRC SYT14 PLCH1

2.75e-03971764EFO_0007878, EFO_0009458
DiseaseFEV/FEC ratio

STARD13 ARHGAP15 MAP2 VPS13C CDH23 PABPC4L SLC1A2 AFAP1L1 ITPR1 FREM2 SBF2 SYNE2 KCNS3 HERC1 CSMD1 MYO15A

2.89e-03122817616EFO_0004713
Diseasecongenital left-sided heart lesions

KCNMB2 MYH7B UPP2

2.96e-03481763EFO_0005938
Diseasemyopathy (implicated_via_orthology)

MYH1 MYH4 MYH7B

2.96e-03481763DOID:423 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

L1CAM SBF2 MIB1 PRKG1 ATP1A1

3.01e-031631765DOID:1826 (implicated_via_orthology)
Diseasetrimethylamine-N-oxide measurement

RTN4 ITPR2

3.07e-03141762EFO_0010541
DiseaseSpastic Paraplegia, Hereditary

L1CAM KIF5A

3.07e-03141762C0037773
DiseaseLeft ventricular noncompaction

MYH7B MIB1

3.07e-03141762C1960469
Diseaseserum selenium measurement

INPP5D PRKG1 CSMD1

3.93e-03531763EFO_0005266
Diseaseestradiol measurement

INTU ARMC9 JAK1 PLEKHA8

4.32e-031101764EFO_0004697
Diseaseattempted suicide

KCNMB2 SYNDIG1 FER1L6 CSMD1 ANO3

4.38e-031781765EFO_0004321
Diseaseplasma beta-amyloid 1-40 measurement

STARD13 TTC29

4.54e-03171762EFO_0005659
Diseaseinterleukin-6 measurement

ITPR1 TRIM67 BTBD7 UPP2

4.61e-031121764EFO_0004810
Diseasepneumonia, COVID-19

MAP2 FAT1 CSMD1 ANO3

4.75e-031131764EFO_0003106, MONDO_0100096
Diseaseneurofilament light chain measurement

GOLGA8B MYO15A SLC38A3

4.82e-03571763EFO_0009178
DiseaseEndometrial Neoplasms

SEMA3F NRIP1 CHD4

5.06e-03581763C0014170
Diseasesphingosine 1-phosphate measurement

ITPR1 C1QL2

5.08e-03181762EFO_0800185
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

HERC1 ANO3

5.08e-03181762HP_0002373
DiseaseMalignant neoplasm of breast

MYH1 NRIP1 PDE2A CENPF SYNE1 FRMPD1 CD109 PDCD4 THOC5 CHD5 SYNE2 TENM1 PLD2 PLEKHA8

5.22e-03107417614C0006142
Diseasemicroglial activation measurement

ARMC9 CCDC88C TTC29

5.31e-03591763EFO_0010940
Diseasebipolar disorder (is_marker_for)

RELN L1CAM

5.66e-03191762DOID:3312 (is_marker_for)
Diseaseplatelet component distribution width

NRIP1 GAPVD1 ARHGAP15 SYNE1 SPTA1 NHLRC2 TEX11 DOCK5 BTBD7 EIF2AK4 HERC1

5.83e-0375517611EFO_0007984
Diseasesugar consumption measurement

FSTL4 NBAS LRPPRC CSMD1

5.87e-031201764EFO_0010158

Protein segments in the cluster

PeptideGeneStartEntry
LAYESKHLLEGAKSE

APOL2

291

Q9BQE5
HLESSHDYLLITEDG

CSMD1

976

Q96PZ7
DSSVIHYDDAAISKL

CHD5

1251

Q8TDI0
HEITYVALVSDKEGS

EIF2AK4

1446

Q9P2K8
DIFLAELYKHLDSSS

NT5C2

396

P49902
RDTGHTHDDDILKTY

ADAM7

41

Q9H2U9
LSSLLGEDKTYHLKD

ADAM7

566

Q9H2U9
PEELSEHLTYLEFKS

RASGRP1

206

O95267
KDLGSVSHLTGYETE

COQ6

401

Q9Y2Z9
ALEDGHDTSSIYLVK

ANGPTL2

281

Q9UKU9
TELHYTGEALKEKAL

ANKRD36

1666

A6QL64
VITAAKELDYEISHG

CDH23

1691

Q9H251
NHDTGEYVLEKLSSS

EAF1

91

Q96JC9
ISLKETIGKYSDDHE

ATG4C

176

Q96DT6
LGKDKDYTDESEHAT

ANO3

106

Q9BYT9
EEGLHTSIYSFDETK

NPR3

226

P17342
EKISEIHYGDTLLST

CCDC60

101

Q8IWA6
IHYGDTLLSTYDDEK

CCDC60

106

Q8IWA6
HLITGDSSINYTEKE

NR2C1

351

P13056
LTIIKDLDYEDATFH

PCDHGA2

301

Q9Y5H1
LATLETLTKHYGAEI

JAK1

271

P23458
HEASSLYSEEKAKLL

PTPN23

366

Q9H3S7
GYDILAEDTITALLH

ITPR2

586

Q14571
GYDILAEDTITALLH

ITPR3

586

Q14573
LEGKLYSSIDHESST

NUDCD1

321

Q96RS6
LLTSLGKVSYEDVDH

KIAA0895L

411

Q68EN5
GDDLKHESLSSFELS

MORC1

601

Q86VD1
TFILESSDLKEYAEH

NPAT

26

Q14207
VLETELHYTGEALKE

ANKRD36C

1526

Q5JPF3
IDELHYTAKGELELA

EXO5

181

Q9H790
TGSLYTSEKLDHEAV

FAT1

1511

Q14517
GLSHLEELDLVYDVK

TCTE1

236

Q5JU00
LYGDTELDVSSLEKH

PTPRE

396

P23469
TSSGEKLLLYHTEET

KCNMB2

121

Q9Y691
HLLTALGKVSYEDVD

KIAA0895

461

Q8NCT3
DISDSKIRYESGDHV

POR

306

P16435
GYDVLAEDTITALLH

ITPR1

586

Q14643
TFLLDSDYERLEHGT

SBF2

1511

Q86WG5
ELAGHDYVLDLVSDL

MYO15A

2276

Q9UKN7
SSYGERHLDDLSLKI

HORMAD2

56

Q8N7B1
SKLADVLEETHYENG

PRKG1

231

Q13976
SEKYILHDASSAEET

LRRC53

1121

A6NM62
KKIYDEETAELSHLT

LONRF1

551

Q17RB8
KLEDSVAYEDHGITV

AQP7P3

286

A6NL99
KLEDSVAYEDHGITV

AQP7B

291

A0A075B734
LSLDELHRKYGTDLS

ATP1A1

46

P05023
AHESELLGLVKEYLD

ARMC9

6

Q7Z3E5
ALTYISEDGDTLVHL

NFKBIE

251

O00221
LISYKHDGTESSEDS

FREM2

1601

Q5SZK8
LSDKAHVEDISGEEY

GPR137C

286

Q8N3F9
DRDLSSKLLYHSDKE

GAPVD1

1061

Q14C86
SVLLDLTYLTGVHED

HERC1

2391

Q15751
LGLSYDSDHCEKDSL

MAPK8IP2

46

Q13387
SEGLTKEYDRLLEEH

BCAP31

216

P51572
EYEELHAHTKELKTS

CCDC88C

1271

Q9P219
SDYDHVSELAKSGKE

FSIP2

5251

Q5CZC0
DEIGSYSEEKLQHLL

HMGXB3

1001

Q12766
TEKLLGSLDLDHTQY

MYH7B

791

A7E2Y1
KEYLLSGDISEAEHC

PDCD4

336

Q53EL6
GQEKYLLLHDISESE

RHOT1

466

Q8IXI2
KVSDDEYTKLLHDGI

PDE2A

576

O00408
ILAKYEIDLDTSDHA

PFKM

751

P08237
HSLGAYILTLDEEKL

PDXDC2P

96

Q6P474
DSVDLGLETVYEKFH

MUL1

146

Q969V5
GYALSHDSLKVEKDL

NRIP1

161

P48552
EKDVTSAKALYEHLT

LRPPRC

1331

P42704
IEDGRLVIHSLDYSD

L1CAM

571

P32004
LIYSVEKDDHTSSLT

KCNS3

341

Q9BQ31
VDVIHSDTDALGYKE

LIPH

201

Q8WWY8
SEKLLGSIDIDHTQY

MYH1

746

P12882
KLEDSVAYEDHGITV

AQP7

286

O14520
KLTDDGHVLDSETYV

POLE

526

Q07864
LAILDTLYEVHGLES

PLEKHA8

501

Q96JA3
GHYVLSESQSELEEK

PRDM10

1081

Q9NQV6
DLSYQDVHLLLGSED

MROH8

161

Q9H579
EALSLAHTYGLDTDL

NBAS

541

A2RRP1
EGHVLTLDALDHYKT

INF2

156

Q27J81
HALEHTYSDKDGLLI

NHLRC2

101

Q8NBF2
EGRKEHITLDTLSYS

RELN

501

P78509
DEKKDDGYTALHLAA

MIB1

626

Q86YT6
LDSETSKEEQEILYH

INTU

316

Q9ULD6
EGKLLYLSESVSEHL

NPAS4

91

Q8IUM7
SLAEHHEVLTEYKEG

QTRT2

66

Q9H974
GNHSYLKSLTDDRTE

BECN2

316

A8MW95
ISLSETVKKVEYDHG

CD109

1331

Q6YHK3
DKYEITVSEDGLTHT

IGSF22

371

Q8N9C0
TYSGITDDDITHKVL

DOC2A

161

Q14183
ETYIHLKEATVEDLG

DOCK5

61

Q9H7D0
LHLDSGDEVYVKLDG

C1QL2

251

Q7Z5L3
KASIEHEALYLEADL

CENPF

1911

P49454
ASDLTFKIHGDEDLS

CCDC18

1356

Q5T9S5
TKDAETGEEVTHYLV

CHD6

386

Q8TD26
SLAYLTAATHGLDEE

COPA

756

P53621
DKDTLLQDYGFHISE

FRMPD1

61

Q5SYB0
GIVYHLSKSELDTID

SLC1A2

491

P43004
SSVESALEHEYDLVK

CMYA5

3096

Q8N3K9
GEDDSLYITKVTTIH

FSTL4

301

Q6MZW2
GLTEDKYLHEASDTL

GIMD1

156

P0DJR0
HLSLKEFSELEQSGY

CD3E

81

P07766
SDVFYELSKDHLLTA

BTBD7

436

Q9P203
VLADVLGYSHLSLED

MACC1

666

Q6ZN28
AYRGASLHDLEKTIE

DNAJC18

286

Q9H819
ELKKRHLEESYDSLS

KIF5A

651

Q12840
HLEESYDSLSDELAK

KIF5A

656

Q12840
LSHYTTILVDSEKED

KL

806

Q9UEF7
RSGYIDEHELDALLK

CALB2

211

P22676
YSVKGLESDEHLGED

CCDC168

381

Q8NDH2
HSLRYFEEESKDLAG

GOLGA8B

146

A8MQT2
HLLQSEIGDYDETLD

FARP2

166

O94887
GEDSSVIHYDDKAIE

CHD4

1241

Q14839
GDDVYILLTVEDISH

MEP1B

576

Q16820
SLELLESFSADIKHY

SERPINA6

136

P08185
EDEASLSLYGKALLH

CPT1B

431

Q92523
KHYGSVELLISSDAD

GARNL3

41

Q5VVW2
EHSDFLELLVKESSG

LAIR2

111

Q6ISS4
TSLSDVEKIHIYSLG

PTPN13

91

Q12923
SLYVGDLHADVTEDL

PABPC4L

11

P0CB38
GYRVTAEDLHLEKET

nan

181

A6NNC1
KELGATYLELHSLDD

RHOBTB3

166

O94955
SGIDTQIIYHKDESE

LAMA4

656

Q16363
DTDETVESYEHLALK

FER1L6

1516

Q2WGJ9
AREYTDLEVSHKSEI

RTN4

886

Q9NQC3
HLAGVLKDYSDITSS

GTF2E2

276

P29084
DEDILYHLDLGTKTH

UPP2

36

O95045
HLYASTGDLLDLEKD

STARD13

466

Q9Y3M8
SEDEALGKYHEALSR

SYT14

91

Q8NB59
NGVESELLHTYSKVD

SLC38A3

346

Q99624
EASGLSLHYEEITKG

SMCHD1

866

A6NHR9
YHAESISAESKLKEA

SRGAP1

171

Q7Z6B7
VGSKDYVLSLDLHDI

SEMA3F

71

Q13275
ASHESKASEIEYKLG

SYNE1

7846

Q8NF91
STYLSHQEKLLLEGE

SYNE2

2131

Q8WXH0
LSADDIKIHTLSYDV

SYNDIG1

136

Q9H7V2
IEAHVDVKTTDGYLL

RPS3A

121

P61247
EGYSEEASLLRHLEK

SYNPO

246

Q8N3V7
GYETLEDLKDIKESH

SAMSN1

266

Q9NSI8
EYIHALDSDAVSKSI

HIF3A

276

Q9Y2N7
SASEYAHRGLDKLEE

PLIN3

91

O60664
SSTELLSHYDSDIKE

ARHGAP15

211

Q53QZ3
SSLLGEEDEEALHYL

SETSIP

116

P0DME0
HILISIKSSDSDESY

INPP5D

801

Q92835
SALLGEEDEEALHYL

SET

106

Q01105
SKSLLNEIESVYDEH

SIN3B

621

O75182
KHLEAYSGCTLELEE

SECISBP2

826

Q96T21
DTHYFIKLGSLEEDL

TENM1

2571

Q9UKZ4
AHTDTTDKALGEKLY

AGMAT

186

Q9BSE5
SEKLLGSIEIDHTQY

MYH4

746

Q9Y623
DDVLSTGVVLYHLKE

STARD9

486

Q9P2P6
AIHKSYLDVSEEGTE

SERPINB11

331

Q96P15
KLSDSYLDPIKSEHD

TET1

281

Q8NFU7
GLLSLLDHEYLSDTT

AFAP1L1

16

Q8TED9
GSYIKDLSVVHSDLS

CTDNEP1

166

O95476
TKDELSSQLTEHEYL

ZBTB43

181

O43298
YLSDKHLGKISEDES

UHRF1BP1L

966

A0JNW5
HLGKISEDESSGLVY

UHRF1BP1L

971

A0JNW5
YAEADHDSLLDLLVT

TGFBRAP1

456

Q8WUH2
GDHADKLSLYSETDS

TRIM67

96

Q6ZTA4
DSKLYLHELLEGSEI

TMEM199

71

Q8N511
ALLESIGSEDVEYAH

TXNDC16

196

Q9P2K2
YSDHLENVSKLVESG

TRIM55

251

Q9BYV6
LEAHALYASSVPKEE

TEP1

1581

Q99973
LHSDDYGKDLTSVNI

SPTBN2

1406

O15020
ITDSAGHILYSKEDA

TMED10

76

P49755
LSKYDHGSDDVLILA

PPM1H

421

Q9ULR3
DLEIYTTGRLEKHLD

STAG2

596

Q8N3U4
SYGLAVEEELHLTEK

RYR3

2526

Q15413
KEYISDDHDRSISIT

UBR1

401

Q8IWV7
SGHGVYELKDESLKD

UBR1

816

Q8IWV7
EDALSHISRTKDYPE

TEX11

846

Q8IYF3
RYLLEGTAETHELAE

VPS13C

2681

Q709C8
EQADYEITLSLHSLG

VPS13C

3081

Q709C8
DKTATKLIGDDHYDS

SPTA1

536

P02549
LLSYSDKKDHLTVEE

PLCH1

221

Q4KWH8
DKEESYESSGEHESL

MAP2

1126

P11137
KIKTAYEESLEHLES

MYH16

646

Q9H6N6
TEEDLSSHYLAKHIE

ZBTB1

431

Q9Y2K1
GLAHLAAEEYETALT

TTC29

281

Q8NA56
EYEQSESSLPELKHL

ZGRF1

471

Q86YA3
SDHSYALLDLDSLKK

THAP3

176

Q8WTV1
HEVDDSSVVGLKYLL

TTC39C

476

Q8N584
LTLGAYKHETEFAEL

YEATS4

161

O95619
VLLDVYLETESHDDS

THOC5

631

Q13769
DTALKTALHLKDYED

WDR35

1046

Q9P2L0
DDLHYRLTDLGDSSE

PLD2

466

O14939
DTAYTKLALDRHTDT

TMLHE

231

Q9NVH6
LIDDYDSTKSGLDHK

SCG3

116

Q8WXD2
TLEDLKIHLQTTDYG

ATP6V0D2

41

Q8N8Y2
LAGVDDIEADILHYS

TMPPE

331

Q6ZT21
TLEDLKLHLQSTDYG

ATP6V0D1

41

P61421
LEELYLVGSLSHDIS

LRRC8C

516

Q8TDW0
TLTFSHLNKEDEGLY

MYOM1

466

P52179
GHEALTGTEKLIETY

PLP1

36

P60201