Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLCO4A1 GJA3 ABCC4 ATP7A GJE1 ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLCO6A1 SLC38A9 SLC1A4 ABCA10 FLVCR1 SCN5A TMEM63A	7.26e-11	1180	42	17	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLCO4A1 GJA3 ABCC4 ATP7A GJE1 ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLCO6A1 SLC38A9 SLC1A4 ABCA10 FLVCR1 SCN5A TMEM63A	2.87e-10	1289	42	17	GO:0005215
GeneOntologyMolecularFunction	A-type (transient outward) potassium channel activity	KCND1 KCND2 KCND3	3.46e-08	4	42	3	GO:0005250
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ABCC4 ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	2.86e-06	758	42	10	GO:0015318
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLCO4A1 ABCC4 ATP7A ATP1A3 SLC13A1 SLCO6A1 SLC1A4 ABCA10	5.78e-06	477	42	8	GO:0022804
GeneOntologyMolecularFunction	channel activity	GJA3 GJE1 KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	1.16e-05	525	42	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GJA3 GJE1 KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	1.18e-05	526	42	8	GO:0022803
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCND1 KCND2 KCND3	2.44e-05	27	42	3	GO:0015271
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	3.22e-05	793	42	9	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SCN5A TMEM63A	4.15e-05	627	42	8	GO:0022890
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SCN5A	4.73e-05	465	42	7	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SCN5A TMEM63A	6.22e-05	664	42	8	GO:0008324
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC4 ATP7A ATP1A3 ABCA10	8.01e-05	109	42	4	GO:0042626
GeneOntologyMolecularFunction	L-glutamine transmembrane transporter activity	SLC38A9 SLC1A4	1.54e-04	9	42	2	GO:0015186
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	ABCC4 SLC13A1 SLC1A4	2.86e-04	61	42	3	GO:1901682
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLCO4A1 ABCC4 SLCO6A1 SLC38A9 SLC1A4	3.59e-04	293	42	5	GO:0008514
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	3.71e-04	459	42	6	GO:0005216
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO4A1 ABCC4	3.87e-04	14	42	2	GO:0015132
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	ATP1A3 KCND1 KCND2 KCND3	4.12e-04	167	42	4	GO:0015079
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO4A1 ABCC4	4.46e-04	15	42	2	GO:0071714
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC4 ATP7A ATP1A3 ABCA10	5.25e-04	178	42	4	GO:0015399
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO4A1 SLCO6A1	6.47e-04	18	42	2	GO:0015347
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCND1 KCND2 KCND3 SCN5A TMEM63A	7.33e-04	343	42	5	GO:0005261
GeneOntologyMolecularFunction	gap junction channel activity	GJA3 GJE1	1.26e-03	25	42	2	GO:0005243
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCND1 KCND2 KCND3	1.29e-03	102	42	3	GO:0005249
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	ABCC4 SLC1A4	2.19e-03	33	42	2	GO:0072349
GeneOntologyMolecularFunction	potassium channel activity	KCND1 KCND2 KCND3	2.46e-03	128	42	3	GO:0005267
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP7A ATP1A3	2.60e-03	36	42	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP7A ATP1A3	2.60e-03	36	42	2	GO:0015662
GeneOntologyMolecularFunction	steroid binding	STARD3NL ATP1A3 SLC38A9	2.74e-03	133	42	3	GO:0005496
GeneOntologyMolecularFunction	wide pore channel activity	GJA3 GJE1	2.75e-03	37	42	2	GO:0022829
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC38A9 SLC1A4	3.36e-03	41	42	2	GO:0015175
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO4A1 SLC13A1 SLCO6A1 SLC1A4	3.40e-03	296	42	4	GO:0015291
GeneOntologyMolecularFunction	amide transmembrane transporter activity	ABCC4 SLC38A9	3.53e-03	42	42	2	GO:0042887
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCND1 KCND2 KCND3	3.99e-03	152	42	3	GO:0022843
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC4 ABCA10	4.77e-03	49	42	2	GO:0140359
GeneOntologyMolecularFunction	molecular sensor activity	SLC38A9 TMEM63A	4.96e-03	50	42	2	GO:0140299
GeneOntologyMolecularFunction	gated channel activity	KCND1 KCND2 KCND3 TMEM63A	5.22e-03	334	42	4	GO:0022836
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ABCC4 SLC13A1 SLC1A4	5.55e-03	171	42	3	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	ATP1A3 SLC13A1 SCN5A	5.55e-03	171	42	3	GO:0015081
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCND1 KCND2 KCND3	6.59e-03	182	42	3	GO:0005244
GeneOntologyMolecularFunction	cholesterol binding	STARD3NL SLC38A9	6.63e-03	58	42	2	GO:0015485
GeneOntologyMolecularFunction	voltage-gated channel activity	KCND1 KCND2 KCND3	6.79e-03	184	42	3	GO:0022832
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP7A ATP1A3	7.54e-03	62	42	2	GO:0019829
GeneOntologyMolecularFunction	lipid transporter activity	SLCO4A1 ABCC4 ABCA10	8.07e-03	196	42	3	GO:0005319
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC4 ATP7A ATP1A3 ABCA10 DNAH14	8.99e-03	614	42	5	GO:0140657
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	ABCC4 SLC38A9 SLC1A4	9.36e-03	207	42	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	ABCC4 SLC38A9 SLC1A4	9.49e-03	208	42	3	GO:0005342
GeneOntologyMolecularFunction	sterol binding	STARD3NL SLC38A9	9.79e-03	71	42	2	GO:0032934
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC38A9 SLC1A4	9.79e-03	71	42	2	GO:0015179
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR56A5 ADORA1 TAS2R1 GPR65 OR56A1 GPR160	9.95e-03	884	42	6	GO:0004930
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO4A1 ABCC4	1.03e-02	73	42	2	GO:0170055
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC38A9 SLC1A4	1.32e-02	83	42	2	GO:0015101
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC4 ATP7A ATP1A3 ABCA10	1.36e-02	441	42	4	GO:0016887
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	ABCC4 SLC1A4	1.54e-02	90	42	2	GO:0008028
GeneOntologyBiologicalProcess	monoatomic ion transport	ADORA1 SLCO4A1 ABCC4 ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLC1A4 FLVCR1 SCN5A TMEM63A	1.98e-06	1374	42	13	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ABCC4 ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLC1A4 SCN5A TMEM63A	6.17e-05	1115	42	10	GO:0034220
GeneOntologyBiologicalProcess	organic anion transport	ADORA1 SLCO4A1 ABCC4 ATP1A3 SLCO6A1 SLC38A9 SLC1A4	7.34e-05	515	42	7	GO:0015711
GeneOntologyBiologicalProcess	monoatomic cation transport	ADORA1 ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 FLVCR1 SCN5A TMEM63A	8.41e-05	1157	42	10	GO:0006812
GeneOntologyBiologicalProcess	regulation of heart contraction	ADORA1 ATP1A3 KCND2 KCND3 SCN5A	1.45e-04	249	42	5	GO:0008016
GeneOntologyBiologicalProcess	metal ion transport	ADORA1 ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 FLVCR1 SCN5A	1.50e-04	1000	42	9	GO:0030001
GeneOntologyBiologicalProcess	carboxylic acid transport	ADORA1 SLCO4A1 ABCC4 ATP1A3 SLC38A9 SLC1A4	1.70e-04	410	42	6	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	ADORA1 SLCO4A1 ABCC4 ATP1A3 SLC38A9 SLC1A4	1.75e-04	412	42	6	GO:0015849
GeneOntologyBiologicalProcess	glutamine transport	SLC38A9 SLC1A4	1.80e-04	10	42	2	GO:0006868
GeneOntologyBiologicalProcess	membrane repolarization	KCND2 KCND3 SCN5A	2.02e-04	56	42	3	GO:0086009
GeneOntologyBiologicalProcess	potassium ion transport	ADORA1 ATP1A3 KCND1 KCND2 KCND3	2.19e-04	272	42	5	GO:0006813
GeneOntologyBiologicalProcess	sulfur compound transport	ABCC4 SLC13A1 SLC1A4	3.14e-04	65	42	3	GO:0072348
GeneOntologyBiologicalProcess	heart contraction	ADORA1 ATP1A3 KCND2 KCND3 SCN5A	3.34e-04	298	42	5	GO:0060047
GeneOntologyBiologicalProcess	cardiac muscle contraction	ADORA1 ATP1A3 KCND3 SCN5A	3.65e-04	167	42	4	GO:0060048
GeneOntologyBiologicalProcess	heart process	ADORA1 ATP1A3 KCND2 KCND3 SCN5A	3.95e-04	309	42	5	GO:0003015
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO4A1 SLCO6A1	4.18e-04	15	42	2	GO:0043252
GeneOntologyBiologicalProcess	regulation of blood circulation	ADORA1 ATP1A3 KCND2 KCND3 SCN5A	5.04e-04	326	42	5	GO:1903522
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SCN5A TMEM63A	5.43e-04	942	42	8	GO:0098655
GeneOntologyBiologicalProcess	circulatory system process	ADORA1 ABCC4 ATP1A3 KCND2 KCND3 SLC1A4 SCN5A	6.34e-04	733	42	7	GO:0003013
GeneOntologyBiologicalProcess	action potential	KCND1 KCND2 KCND3 SCN5A	7.33e-04	201	42	4	GO:0001508
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	KCND2 KCND3 SCN5A	7.39e-04	87	42	3	GO:0086001
GeneOntologyBiologicalProcess	export across plasma membrane	ABCC4 ATP1A3 KCND3	8.42e-04	91	42	3	GO:0140115
GeneOntologyBiologicalProcess	regulation of membrane potential	ADORA1 ATP1A3 KCND1 KCND2 KCND3 SCN5A	8.83e-04	559	42	6	GO:0042391
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	ADORA1 KCND3 SCN5A	8.97e-04	93	42	3	GO:0086003
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ATP7A ATP1A3 SLC13A1 KCND1 KCND2 KCND3 SLC1A4 SCN5A	8.98e-04	1017	42	8	GO:0098660
GeneOntologyBiologicalProcess	striated muscle contraction	ADORA1 ATP1A3 KCND3 SCN5A	9.75e-04	217	42	4	GO:0006941
GeneOntologyCellularComponent	cation channel complex	KCND1 KCND2 KCND3 SLCO6A1 SCN5A	1.17e-04	235	43	5	GO:0034703
GeneOntologyCellularComponent	dendritic spine	ADORA1 ATP1A3 KCND1 KCND2 KCND3	1.34e-04	242	43	5	GO:0043197
GeneOntologyCellularComponent	neuron spine	ADORA1 ATP1A3 KCND1 KCND2 KCND3	1.48e-04	247	43	5	GO:0044309
GeneOntologyCellularComponent	plasma membrane protein complex	GJA3 GJE1 ATP1A3 KCND1 KCND2 KCND3 SLCO6A1 SCN5A	1.72e-04	785	43	8	GO:0098797
GeneOntologyCellularComponent	dendrite	ADORA1 ATP7A ATP1A3 KCND1 KCND2 KCND3 SLC1A4 FAT3	3.15e-04	858	43	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ADORA1 ATP7A ATP1A3 KCND1 KCND2 KCND3 SLC1A4 FAT3	3.20e-04	860	43	8	GO:0097447
GeneOntologyCellularComponent	basolateral plasma membrane	ADORA1 SLCO4A1 ABCC4 ATP7A SLCO6A1	4.87e-04	320	43	5	GO:0016323
GeneOntologyCellularComponent	sarcolemma	ATP1A3 KCND2 KCND3 SCN5A	6.19e-04	190	43	4	GO:0042383
GeneOntologyCellularComponent	transmembrane transporter complex	ATP1A3 KCND1 KCND2 KCND3 SLCO6A1 SCN5A	6.62e-04	523	43	6	GO:1902495
GeneOntologyCellularComponent	basal plasma membrane	ADORA1 SLCO4A1 ABCC4 ATP7A SLCO6A1	7.68e-04	354	43	5	GO:0009925
GeneOntologyCellularComponent	transporter complex	ATP1A3 KCND1 KCND2 KCND3 SLCO6A1 SCN5A	8.60e-04	550	43	6	GO:1990351
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCND1 KCND2 KCND3	8.68e-04	91	43	3	GO:0008076
GeneOntologyCellularComponent	connexin complex	GJA3 GJE1	9.30e-04	22	43	2	GO:0005922
GeneOntologyCellularComponent	basal part of cell	ADORA1 SLCO4A1 ABCC4 ATP7A SLCO6A1	1.03e-03	378	43	5	GO:0045178
GeneOntologyCellularComponent	monoatomic ion channel complex	KCND1 KCND2 KCND3 SLCO6A1 SCN5A	1.03e-03	378	43	5	GO:0034702
GeneOntologyCellularComponent	potassium channel complex	KCND1 KCND2 KCND3	1.28e-03	104	43	3	GO:0034705
GeneOntologyCellularComponent	neuronal cell body	ADORA1 ATP7A ATP1A3 KCND1 KCND2 KCND3 SLC1A4	1.45e-03	835	43	7	GO:0043025
GeneOntologyCellularComponent	caveola	KCND2 KCND3 SCN5A	1.54e-03	111	43	3	GO:0005901
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	KCND2 KCND3	1.62e-03	29	43	2	GO:0097038
GeneOntologyCellularComponent	calyx of Held	ADORA1 ATP1A3	2.49e-03	36	43	2	GO:0044305
GeneOntologyCellularComponent	gap junction	GJA3 GJE1	2.63e-03	37	43	2	GO:0005921
GeneOntologyCellularComponent	cell body	ADORA1 ATP7A ATP1A3 KCND1 KCND2 KCND3 SLC1A4	2.66e-03	929	43	7	GO:0044297
GeneOntologyCellularComponent	membrane protein complex	GJA3 GJE1 ATP1A3 KCND1 KCND2 KCND3 SLCO6A1 SLC38A9 SCN5A	2.97e-03	1498	43	9	GO:0098796
GeneOntologyCellularComponent	somatodendritic compartment	ADORA1 ATP7A ATP1A3 KCND1 KCND2 KCND3 SLC1A4 FAT3	3.19e-03	1228	43	8	GO:0036477
GeneOntologyCellularComponent	plasma membrane raft	KCND2 KCND3 SCN5A	3.42e-03	147	43	3	GO:0044853
GeneOntologyCellularComponent	neuronal cell body membrane	ATP1A3 KCND2	3.54e-03	43	43	2	GO:0032809
GeneOntologyCellularComponent	cell body membrane	ATP1A3 KCND2	4.21e-03	47	43	2	GO:0044298
GeneOntologyCellularComponent	synaptic membrane	ADORA1 ATP1A3 KCND1 KCND2 KCND3	6.66e-03	583	43	5	GO:0097060
Domain	DUF3399	KCND1 KCND2 KCND3	1.22e-08	3	44	3	PF11879
Domain	K_chnl_volt-dep_Kv4	KCND1 KCND2 KCND3	1.22e-08	3	44	3	IPR003975
Domain	Shal-type	KCND1 KCND2 KCND3	1.22e-08	3	44	3	PF11601
Domain	Shal-type_N	KCND1 KCND2 KCND3	1.22e-08	3	44	3	IPR021645
Domain	K_chnl_volt-dep_Kv4_C	KCND1 KCND2 KCND3	1.22e-08	3	44	3	IPR024587
Domain	Channel_four-helix_dom	KCND1 KCND2 KCND3 SCN5A	9.66e-06	57	44	4	IPR027359
Domain	-	KCND1 KCND2 KCND3 SCN5A	9.66e-06	57	44	4	1.20.120.350
Domain	K_chnl_volt-dep_Kv	KCND1 KCND2 KCND3	3.43e-05	27	44	3	IPR003968
Domain	VG_K_chnl	KCND1 KCND2 KCND3	6.33e-05	33	44	3	IPR028325
Domain	Ion_trans_dom	KCND1 KCND2 KCND3 SCN5A	1.48e-04	114	44	4	IPR005821
Domain	Ion_trans	KCND1 KCND2 KCND3 SCN5A	1.48e-04	114	44	4	PF00520
Domain	BTB_2	KCND1 KCND2 KCND3	2.63e-04	53	44	3	PF02214
Domain	T1-type_BTB	KCND1 KCND2 KCND3	2.63e-04	53	44	3	IPR003131
Domain	OA_transporter	SLCO4A1 SLCO6A1	3.53e-04	12	44	2	IPR004156
Domain	OATP	SLCO4A1 SLCO6A1	3.53e-04	12	44	2	PF03137
Domain	NPIP	NPIPA2 NPIPB9	4.85e-04	14	44	2	IPR009443
Domain	-	ATP7A ATP1A3	2.57e-03	32	44	2	2.70.150.10
Domain	-	ATP7A ATP1A3	2.57e-03	32	44	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP7A ATP1A3	3.07e-03	35	44	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP7A ATP1A3	3.25e-03	36	44	2	IPR018303
Domain	P_typ_ATPase	ATP7A ATP1A3	3.25e-03	36	44	2	IPR001757
Domain	ATPASE_E1_E2	ATP7A ATP1A3	3.25e-03	36	44	2	PS00154
Domain	Kazal_2	SLCO4A1 SLCO6A1	3.25e-03	36	44	2	PF07648
Domain	ATPase_P-typ_transduc_dom_A	ATP7A ATP1A3	3.43e-03	37	44	2	IPR008250
Domain	E1-E2_ATPase	ATP7A ATP1A3	3.43e-03	37	44	2	PF00122
Domain	MFS_dom	SLCO4A1 SLCO6A1 FLVCR1	3.86e-03	134	44	3	IPR020846
Domain	ABC_transporter_CS	ABCC4 ABCA10	4.40e-03	42	44	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCC4 ABCA10	5.71e-03	48	44	2	PS50893
Domain	ABC_tran	ABCC4 ABCA10	5.71e-03	48	44	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCC4 ABCA10	5.95e-03	49	44	2	PS00211
Domain	KAZAL_2	SLCO4A1 SLCO6A1	6.18e-03	50	44	2	PS51465
Domain	ABC_transporter-like	ABCC4 ABCA10	6.18e-03	50	44	2	IPR003439
Domain	Kazal_dom	SLCO4A1 SLCO6A1	6.43e-03	51	44	2	IPR002350
Domain	BTB	KCND1 KCND2 KCND3	8.73e-03	180	44	3	SM00225
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND1 KCND2 KCND3	3.70e-07	7	32	3	M27457
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND1 KCND2 KCND3	3.70e-07	7	32	3	MM15199
Pathway	REACTOME_CARDIAC_CONDUCTION	ATP1A3 KCND1 KCND2 KCND3 SCN5A	1.02e-05	130	32	5	M27454
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLCO4A1 ABCC4 LMF1 ATP7A ATP1A3 SLC13A1 SLC1A4 ABCA10 FLVCR1	2.60e-05	736	32	9	M27287
Pathway	REACTOME_CARDIAC_CONDUCTION	ATP1A3 KCND1 KCND2 KCND3	8.26e-05	103	32	4	MM15196
Pathway	REACTOME_MUSCLE_CONTRACTION	ATP1A3 KCND1 KCND2 KCND3 SCN5A	8.65e-05	203	32	5	M5485
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLCO4A1 ABCC4 LMF1 ATP7A ATP1A3 SLC13A1 SLC1A4 FLVCR1	1.07e-04	681	32	8	MM14985
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCND1 KCND2 KCND3	1.07e-04	41	32	3	MM14546
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCND1 KCND2 KCND3	1.23e-04	43	32	3	M1056
Pathway	REACTOME_MUSCLE_CONTRACTION	ATP1A3 KCND1 KCND2 KCND3	5.04e-04	165	32	4	MM15026
Pathway	REACTOME_POTASSIUM_CHANNELS	KCND1 KCND2 KCND3	1.40e-03	98	32	3	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	KCND1 KCND2 KCND3	1.61e-03	103	32	3	M1073
Pubmed	Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.	KCND1 KCND2 KCND3	2.02e-09	3	45	3	18371079
Pubmed	Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).	KCND1 KCND2 KCND3	2.02e-09	3	45	3	10729221
Pubmed	Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis.	KCND2 KCND3 SCN5A	7.29e-07	14	45	3	23542581
Pubmed	Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.	KCND1 KCND2 KCND3	9.11e-07	15	45	3	10479680
Pubmed	Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.	KCND2 KCND3	1.64e-06	2	45	2	34386734
Pubmed	Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.	KCND2 KCND3	1.64e-06	2	45	2	17122053
Pubmed	Mutations in the genes KCND2 and KCND3 encoding the ion channels Kv4.2 and Kv4.3, conducting the cardiac fast transient outward current (ITO,f), are not a frequent cause of long QT syndrome.	KCND2 KCND3	1.64e-06	2	45	2	15563876
Pubmed	S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.	KCND1 KCND2	1.64e-06	2	45	2	24675763
Pubmed	Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.	KCND2 KCND3	1.64e-06	2	45	2	26196737
Pubmed	Genomic organisation and chromosomal localisation of two members of the KCND ion channel family, KCND2 and KCND3.	KCND2 KCND3	1.64e-06	2	45	2	10942109
Pubmed	Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.	KCND2 KCND3	1.64e-06	2	45	2	9843794
Pubmed	Analysis of the arrhythmogenic substrate in human heart failure.	KCND3 SCN5A	1.64e-06	2	45	2	23036686
Pubmed	Brugada Syndrome	KCND2 KCND3 SCN5A	4.02e-06	24	45	3	20301690
Pubmed	Pituitary adenylate cyclase activating polypeptide reduces expression of Kv1.4 and Kv4.2 subunits underlying A-type K(+) current in adult mouse olfactory neuroepithelia.	KCND1 KCND2	4.91e-06	3	45	2	16426762
Pubmed	I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.	KCND2 KCND3	4.91e-06	3	45	2	22815518
Pubmed	Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.	KCND2 KCND3	4.91e-06	3	45	2	20371829
Pubmed	Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.	KCND2 KCND3	4.91e-06	3	45	2	30758987
Pubmed	ChIPping away at potassium channel regulation.	KCND1 KCND2	4.91e-06	3	45	2	10700246
Pubmed	Role of heteromultimers in the generation of myocardial transient outward K+ currents.	KCND2 KCND3	4.91e-06	3	45	2	11909823
Pubmed	A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.	KCND2 KCND3	4.91e-06	3	45	2	22615428
Pubmed	Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.	SLCO4A1 SLCO6A1	4.91e-06	3	45	2	25301452
Pubmed	Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.	KCND2 KCND3	9.81e-06	4	45	2	26311767
Pubmed	Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.	KCND2 KCND3	9.81e-06	4	45	2	15662035
Pubmed	IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.	KCND2 KCND3	9.81e-06	4	45	2	26152125
Pubmed	Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.	KCND2 KCND3	9.81e-06	4	45	2	14980207
Pubmed	Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).	KCND1 KCND2	9.81e-06	4	45	2	15454437
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	KCND2 KCND3 SCN5A	1.18e-05	34	45	3	26378152
Pubmed	Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.	KCND2 KCND3	1.63e-05	5	45	2	19213956
Pubmed	Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.	ADORA1 ABCC4	1.63e-05	5	45	2	25401477
Pubmed	The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.	KCND2 KCND3	1.63e-05	5	45	2	16239150
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCND1 KCND2 KCND3	1.93e-05	40	45	3	16382104
Pubmed	GWAS identifies four novel eosinophilic esophagitis loci.	CAPN14 TSLP	2.45e-05	6	45	2	25407941
Pubmed	Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.	KCND2 KCND3	2.45e-05	6	45	2	20943905
Pubmed	Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).	KCND2 KCND3	2.45e-05	6	45	2	18603586
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCND1 KCND2 KCND3 SCN5A	3.21e-05	139	45	4	16985003
Pubmed	Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.	KCND1 KCND2	3.42e-05	7	45	2	25003238
Pubmed	Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.	KCND2 KCND3	3.42e-05	7	45	2	28646025
Pubmed	Proteomic analyses of native brain K(V)4.2 channel complexes.	KCND1 KCND2	4.56e-05	8	45	2	19713751
Pubmed	Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.	KCND3 SCN5A	7.32e-05	10	45	2	32109384
Pubmed	Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.	KCND2 SCN5A	8.94e-05	11	45	2	22992950
Pubmed	A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.	TMEM232 TSLP	1.94e-04	16	45	2	22036096
Pubmed	Genetic determinants of P wave duration and PR segment.	KCND3 SCN5A	2.20e-04	17	45	2	24850809
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ADORA1 SLCO4A1 STARD3NL SLC1A4 ACTR10 TMEM63A	2.66e-04	697	45	6	28298427
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	ATP7A VPS35L	2.76e-04	19	45	2	25355947
Pubmed	Long QT Syndrome Overview	SCN5A CHST3	2.76e-04	19	45	2	20301308
Pubmed	GATA6 is a regulator of sinus node development and heart rhythm.	KCND2 SCN5A	3.06e-04	20	45	2	33443158
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	NEMP1 ABCC4 ATP7A SLC38A9 SLC1A4 CHST3	3.13e-04	719	45	6	35337019
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	ABCC4 ATP7A	3.38e-04	21	45	2	31541095
Pubmed	Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.	CAPN14 TSLP	3.38e-04	21	45	2	25017104
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC4 ABCA10	3.72e-04	22	45	2	8894702
Pubmed	Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.	GJA3 SLC13A1 FAT3	3.76e-04	108	45	3	31202927
Pubmed	Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.	ATP1A3 KCND2	4.07e-04	23	45	2	25190801
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ABCC4 LMF1 KCND3 SLC38A9 DNAH14 FLVCR1 VPS35L TMEM63A	5.81e-04	1489	45	8	28611215
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP7A ATP1A3	6.50e-04	29	45	2	15071553
Pubmed	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	SLC13A1 KCND2	6.96e-04	30	45	2	19401682
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	KCND2 SCN5A	6.96e-04	30	45	2	39366945
Pubmed	Ion channel expression in the developing enteric nervous system.	KCND2 KCND3	1.06e-03	37	45	2	25798587
Pubmed	Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system.	SLC13A1 ACTR10	1.12e-03	38	45	2	18407958
Interaction	CX3CL1 interactions	ABCC4 ATP7A ATP1A3 FAT3	1.17e-05	71	40	4	int:CX3CL1
Interaction	KCNIP1 interactions	KCND1 KCND2 KCND3	1.62e-05	25	40	3	int:KCNIP1
Cytoband	5q22.1	TMEM232 TSLP	5.14e-05	11	45	2	5q22.1
Cytoband	1q42.12	DNAH14 TMEM63A	1.42e-04	18	45	2	1q42.12
Cytoband	Ensembl 112 genes in cytogenetic band chr5q22	TMEM232 TSLP	1.55e-03	59	45	2	chr5q22
GeneFamily	Potassium voltage-gated channels	KCND1 KCND2 KCND3	4.32e-05	40	31	3	274
GeneFamily	Solute carriers	SLCO4A1 SLC13A1 SLCO6A1 SLC38A9 SLC1A4 FLVCR1	4.85e-05	395	31	6	752
GeneFamily	Olfactory receptors, family 56	OR56A5 OR56A1	1.02e-04	9	31	2	167
GeneFamily	Gap junction proteins	GJA3 GJE1	6.43e-04	22	31	2	314
GeneFamily	G protein-coupled receptors, Class A orphans	GPR65 GPR160	7.88e-03	78	31	2	262
Drug	methanethiosulfonate	GJA3 KCND1 KCND2 KCND3 SCN5A	1.44e-06	103	43	5	CID004188587
Drug	butamben	KCND1 KCND2 KCND3	2.81e-06	15	43	3	CID000002482
Drug	flecainide	KCND1 KCND2 KCND3 SCN5A	9.77e-06	71	43	4	CID000003355
Drug	clofilium	KCND1 KCND2 KCND3 SCN5A	1.15e-05	74	43	4	CID000002798
Drug	chromanol 293B	KCND1 KCND3 SCN5A	3.29e-05	33	43	3	CID000121846
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	TAS2R1 ATP1A3 SLC1A4 CHST3 TMEM63A	3.32e-05	196	43	5	2277_UP
Drug	verapamil	ABCC4 ATP1A3 KCND1 KCND2 KCND3 ABCA10 SCN5A	3.38e-05	490	43	7	CID000002520
Drug	Netilmicin sulfate [56931-57-2]; Up 200; 2.8uM; MCF7; HT_HG-U133A	ADORA1 TAS2R1 LMF1 KCND3 AOX1	3.40e-05	197	43	5	3524_UP
Drug	verruculogen	KCND2 KCND3	3.47e-05	5	43	2	CID000104862
Drug	pyraclofos	KCND1 KCND2 KCND3 SCN5A	4.76e-05	106	43	4	CID000093460
Drug	heptanol	GJA3 KCND2 SCN5A	6.84e-05	42	43	3	CID000008129
Disease	Eosinophilic esophagitis	CAPN14 TSLP	1.24e-05	4	43	2	C0341106
Disease	Sudden Cardiac Arrest	KCND2 KCND3	5.78e-05	8	43	2	C1720824
Disease	epilepsy (implicated_via_orthology)	ATP1A3 SLC13A1 SLC1A4 SCN5A	9.36e-05	163	43	4	DOID:1826 (implicated_via_orthology)
Disease	Brugada Syndrome 1	KCND3 SCN5A	1.60e-04	13	43	2	C4551804
Disease	P wave duration	KCND3 SCN5A	2.15e-04	15	43	2	EFO_0005094
Disease	Brugada Syndrome (disorder)	KCND3 SCN5A	5.61e-04	24	43	2	C1142166
Disease	chronic rhinosinusitis	TMEM232 TSLP	1.13e-03	34	43	2	EFO_1000024
Disease	childhood onset asthma	ADORA1 TMEM232 TSLP FLVCR1	1.41e-03	334	43	4	MONDO_0005405

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLIFLTYVLSFIFRK	ABCA10	1026	Q8WWZ4
IVYAFRIQKFRVTFL	ADORA1	286	P30542
FRETLTRVLFKYFEV	ACTR10	101	Q9NZ32
FVLRVFSRKHIFYEI	CAPN14	486	A8MX76
RTLIISFLFKFYLEV	AOX1	516	Q06278
TVKRIRINFVFALIY	ATP7A	1351	Q04656
FVTLRVFRVFRIFKF	KCND1	291	Q9NSA2
FVTLRVFRVFRIFKF	KCND3	286	Q9UK17
EYVIKVSARVRFFFP	MAGEA1	281	P43355
VLFLHYVKVFIFRYL	MMS22L	131	Q6ZRQ5
LFIFVLIYVRVFRKS	ERVMER34-1	501	Q9H9K5
YSVIVIRRFDPKLFL	NEMP1	151	O14524
TLRVFRVFRIFKFSR	KCND2	291	Q9NZV8
FLFLILVFSIIRRRF	TMEM63A	61	O94886
LLIITVFLRSYKFAI	NPIPA2	61	E9PIF3
ILYFRDFVLLSIRFT	GPR160	76	Q9UJ42
LIVLSYFFILKTVLR	OR56A5	216	P0C7T3
LGIIFIFLRRYFLET	ABCC4	871	O15439
KRFLSYPRFVEVLVV	ADAMTS9	286	Q9P2N4
AFLLLIIRRVFEKFV	CERS3	46	Q8IU89
FILVVLFIVFRKKVF	FAT3	4166	Q8TDW7
LFVAEIFEIIFRRLY	GJE1	186	A6NN92
RRFVVLLIFSLYSLV	FLVCR1	106	Q9Y5Y0
FTFTLDLRYIIIVFV	FLVCR1	416	Q9Y5Y0
YRRLLETFFKFVMLV	DNAH14	416	Q0VDD8
FLIFVYDEIRKLILR	ATP1A3	986	P13637
LRTYVFNIIFKTLFE	GJA3	146	Q9Y6H8
YILVYRRFLFVVFTV	SLC13A1	6	Q9BZW2
SVLYLIFLVTFKAVR	SLC38A9	321	Q8NBW4
IIIIIGFLRRYTFNI	NPIPB9	76	F8W1W9
RKTLSFFLVFVPIYL	PTX4	6	Q96A99
IFLSYTFILRAVLRF	OR56A1	221	Q8NGH5
RLVKLVVNFLFYFRT	PLEKHJ1	36	Q9NW61
IIQKYFFSPTLFRVI	SCN5A	1611	Q14524
IIFTTIAFFIYKRRL	SLCO6A1	681	Q86UG4
GLLVIFSAIIYFFIR	IMPG2	1111	Q9BZV3
RKPLLLVFIFVVIFF	SLCO4A1	576	Q96BD0
RSKYALFLVFVVIVF	CHST3	21	Q7LGC8
KFHIRRFIFLFFILV	TAS2R1	251	Q9NYW7
FFKIASIRELIPRFY	VPS35L	281	Q7Z3J2
IYFVFTRKNPFRFLL	SLC1A4	316	P43007
AKIGYLVFLRLFIFF	TMEM232	166	C9JQI7
FLLAVFRFKVLILAY	STARD3NL	101	O95772
LLYVLSVSFRKIFIL	TSLP	6	Q969D9
VVYPLKFFFLRTRRF	GPR65	116	Q8IYL9
FIILFKVFLFPRITI	PRO0628	26	Q9UI54
LTRIVLLKALAFVYF	LMF1	51	Q96S06