Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	4.11e-06	2	41	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	4.11e-06	2	41	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	4.11e-06	2	41	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	4.11e-06	2	41	2	GO:0004354
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	8.58e-05	7	41	2	GO:0070728
GeneOntologyMolecularFunction	amino acid binding	SLC38A9 GLUD1 GLUD2	4.52e-04	73	41	3	GO:0016597
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors	GLUD1 GLUD2	7.63e-04	20	41	2	GO:0016638
GeneOntologyMolecularFunction	NAD+ binding	GLUD1 GLUD2	7.63e-04	20	41	2	GO:0070403
GeneOntologyMolecularFunction	lysine-acetylated histone binding	BRD3 BRD2	1.73e-03	30	41	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	BRD3 BRD2	1.84e-03	31	41	2	GO:0140033
GeneOntologyBiologicalProcess	glutamate biosynthetic process	GLUD1 GLUD2	3.65e-05	5	40	2	GO:0006537
GeneOntologyBiologicalProcess	response to aluminum ion	GLUD1 GLUD2	5.47e-05	6	40	2	GO:0010044
GeneOntologyBiologicalProcess	glutamate catabolic process	GLUD1 GLUD2	1.02e-04	8	40	2	GO:0006538
GeneOntologyBiologicalProcess	positive regulation of T-helper 17 cell lineage commitment	IL12RB1 BRD2	1.02e-04	8	40	2	GO:2000330
GeneOntologyCellularComponent	extrinsic component of membrane	ATP6V1A OLFM2 RPH3A CRKL PIK3R3	6.55e-05	230	39	5	GO:0019898
GeneOntologyCellularComponent	extrinsic component of postsynaptic membrane	OLFM2 CRKL	7.65e-04	22	39	2	GO:0098890
GeneOntologyCellularComponent	postsynaptic membrane	KCNAB2 GRIK2 OLFM2 RPH3A CRKL	8.92e-04	405	39	5	GO:0045211
GeneOntologyCellularComponent	extrinsic component of synaptic vesicle membrane	ATP6V1A RPH3A	9.90e-04	25	39	2	GO:0098850
HumanPheno	Neonatal onset	SMN1 GRIK2 SLC10A2 AEBP1 SELENON RBL2 COQ9 GLUD1	6.73e-06	500	13	8	HP:0003623
HumanPheno	Prominent veins on trunk	ATP6V1A AEBP1	5.99e-05	5	13	2	HP:0007457
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	4.47e-06	2	40	2	PF02812
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	4.47e-06	2	40	2	IPR033922
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	4.47e-06	2	40	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	4.47e-06	2	40	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	4.47e-06	2	40	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.47e-06	2	40	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.47e-06	2	40	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	4.47e-06	2	40	2	IPR033524
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	4.47e-06	2	40	2	PS00074
Domain	BET	BRD3 BRD2	2.68e-05	4	40	2	PF17035
Domain	NET_dom	BRD3 BRD2	2.68e-05	4	40	2	IPR027353
Domain	NET	BRD3 BRD2	2.68e-05	4	40	2	PS51525
Domain	Bromodomain_CS	BRD3 BRD2	1.41e-03	26	40	2	IPR018359
Domain	BROMODOMAIN_1	BRD3 BRD2	2.84e-03	37	40	2	PS00633
Domain	Bromodomain	BRD3 BRD2	2.99e-03	38	40	2	PF00439
Domain	BROMODOMAIN_2	BRD3 BRD2	3.48e-03	41	40	2	PS50014
Domain	BROMO	BRD3 BRD2	3.65e-03	42	40	2	SM00297
Domain	Bromodomain	BRD3 BRD2	3.65e-03	42	40	2	IPR001487
Domain	-	BRD3 BRD2	3.65e-03	42	40	2	1.20.920.10
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.36e-06	2	41	2	15750346
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	1.36e-06	2	41	2	21446915
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	1.36e-06	2	41	2	1711373
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	1.36e-06	2	41	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	1.36e-06	2	41	2	28621566
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	1.36e-06	2	41	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	1.36e-06	2	41	2	22658952
Pubmed	The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription.	BRD3 BRD2	1.36e-06	2	41	2	18406326
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	1.36e-06	2	41	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	1.36e-06	2	41	2	20529287
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	1.36e-06	2	41	2	23595828
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	1.36e-06	2	41	2	25124006
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	1.36e-06	2	41	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	1.36e-06	2	41	2	24593767
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	1.36e-06	2	41	2	23673664
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	1.36e-06	2	41	2	38124277
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	1.36e-06	2	41	2	37154294
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	1.36e-06	2	41	2	19015267
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	1.36e-06	2	41	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	1.36e-06	2	41	2	39052831
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	1.36e-06	2	41	2	22924626
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	1.36e-06	2	41	2	24442550
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	1.36e-06	2	41	2	28911206
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	1.36e-06	2	41	2	27137930
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	1.36e-06	2	41	2	19448744
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	1.36e-06	2	41	2	26440896
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	1.36e-06	2	41	2	22875990
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	1.36e-06	2	41	2	12742085
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	1.36e-06	2	41	2	11032875
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	1.36e-06	2	41	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.36e-06	2	41	2	15044002
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	1.36e-06	2	41	2	11950837
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	1.36e-06	2	41	2	22138648
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	1.36e-06	2	41	2	29943084
Pubmed	Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.	BRD3 BRD2	1.36e-06	2	41	2	9373153
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	1.36e-06	2	41	2	34220417
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	1.36e-06	2	41	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	1.36e-06	2	41	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	1.36e-06	2	41	2	27422263
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	1.36e-06	2	41	2	26241911
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	4.06e-06	3	41	2	29784783
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	4.06e-06	3	41	2	3585334
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	4.06e-06	3	41	2	12054821
Pubmed	GOT1 regulates CD8+ effector and memory T cell generation.	GLUD1 GLUD2	4.06e-06	3	41	2	36640309
Pubmed	Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.	GLUD1 GLUD2	4.06e-06	3	41	2	37871770
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	4.06e-06	3	41	2	31704028
Pubmed	Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.	BRD3 BRD2	4.06e-06	3	41	2	24049186
Pubmed	[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues].	BRD3 BRD2	4.06e-06	3	41	2	12600283
Pubmed	Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.	GLUD1 GLUD2	4.06e-06	3	41	2	23560106
Pubmed	Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.	GLUD1 GLUD2	4.06e-06	3	41	2	29229616
Pubmed	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.	GLUD1 GLUD2	4.06e-06	3	41	2	30002133
Pubmed	Phylogeny and structure of the RING3 gene.	BRD3 BRD2	4.06e-06	3	41	2	8781126
Pubmed	Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	GLUD1 GLUD2	4.06e-06	3	41	2	30315226
Pubmed	Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.	GLUD1 GLUD2	4.06e-06	3	41	2	20670938
Pubmed	Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.	BRD3 BRD2	4.06e-06	3	41	2	28945351
Pubmed	Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.	GLUD1 GLUD2	4.06e-06	3	41	2	24295216
Pubmed	Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.	BRD3 BRD2	4.06e-06	3	41	2	31792058
Pubmed	BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.	BRD3 BRD2	4.06e-06	3	41	2	29437854
Pubmed	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.	GLUD1 GLUD2	8.12e-06	4	41	2	23663782
Pubmed	Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.	GLUD1 GLUD2	8.12e-06	4	41	2	24872547
Pubmed	Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.	GLUD1 GLUD2	8.12e-06	4	41	2	25721396
Pubmed	Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.	BRD3 BRD2	8.12e-06	4	41	2	24248598
Pubmed	GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.	GLUD1 GLUD2	8.12e-06	4	41	2	39121856
Pubmed	Expression of BET genes in testis of men with different spermatogenic impairments.	BRD3 BRD2	8.12e-06	4	41	2	22035730
Pubmed	A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.	GLUD1 GLUD2	8.12e-06	4	41	2	2566156
Pubmed	Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.	BRD3 BRD2	8.12e-06	4	41	2	22912406
Pubmed	SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.	GLUD1 GLUD2	1.35e-05	5	41	2	16959573
Pubmed	Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14.	GLUD1 GLUD2	1.35e-05	5	41	2	2045113
Pubmed	Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.	GLUD1 GLUD2	1.35e-05	5	41	2	3182016
Pubmed	Genomic organization and chromosomal localization of the mouse synexin gene.	GLUD1 GLUD2	1.35e-05	5	41	2	8053909
Pubmed	Macrophage-derived glutamine boosts satellite cells and muscle regeneration.	GLUD1 GLUD2	1.35e-05	5	41	2	33116312
Pubmed	Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.	GLUD1 GLUD2	1.35e-05	5	41	2	7873882
Pubmed	The human glutamate dehydrogenase gene family: gene organization and structural characterization.	GLUD1 GLUD2	2.03e-05	6	41	2	8486350
Pubmed	Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins.	BRD3 BRD2	2.03e-05	6	41	2	31444232
Pubmed	Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.	GLUD1 GLUD2	2.84e-05	7	41	2	10454512
Pubmed	RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.	GLUD1 GLUD2	2.84e-05	7	41	2	19498109
Pubmed	BRD4 Promotes Gastric Cancer Progression and Metastasis through Acetylation-Dependent Stabilization of Snail.	BRD3 BRD2	3.78e-05	8	41	2	31311807
Pubmed	GluD1 is a signal transduction device disguised as an ionotropic receptor.	GLUD1 GLUD2	3.78e-05	8	41	2	34135511
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	GLUD1 GLUD2	3.78e-05	8	41	2	34857752
Pubmed	Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice.	GLUD1 GLUD2	3.78e-05	8	41	2	26443267
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	ATP6V1A RPH3A GLUD1 GLUD2	4.42e-05	166	41	4	27160897
Pubmed	Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.	GLUD1 GLUD2	4.86e-05	9	41	2	8415706
Pubmed	Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice.	GLUD1 GLUD2	4.86e-05	9	41	2	9756038
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	GLUD1 GLUD2	4.86e-05	9	41	2	2293612
Pubmed	Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.	BRD3 BRD2	7.41e-05	11	41	2	28805820
Pubmed	Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis.	GLUD1 GLUD2	7.41e-05	11	41	2	11792727
Pubmed	Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.	GLUD1 GLUD2	7.41e-05	11	41	2	38658571
Pubmed	Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.	BRD2 RBL2	7.41e-05	11	41	2	15949438
Pubmed	Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a.	GLUD1 GLUD2	8.88e-05	12	41	2	7896292
Pubmed	Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.	GLUD1 GLUD2	8.88e-05	12	41	2	17923681
Pubmed	Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis.	GLUD1 GLUD2	1.05e-04	13	41	2	15609325
Pubmed	Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.	RBL2 MYBL1	1.22e-04	14	41	2	17531812
Pubmed	SNAT7 regulates mTORC1 via macropinocytosis.	ATP6V1A SLC38A9	1.22e-04	14	41	2	35561222
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	SLAMF8 SLC38A9 TMEM59 COQ9 APLNR	1.47e-04	430	41	5	16303743
Pubmed	Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping.	GLUD1 GLUD2	1.82e-04	17	41	2	1617216
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	SLAMF8 KCNAB2 DNAI4 SMG7 SELENON TMEM59 ZBTB8B	1.84e-04	1031	41	7	16710414
Pubmed	Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor.	GLUD1 GLUD2	2.05e-04	18	41	2	2338144
Pubmed	The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome.	GLUD1 GLUD2	2.29e-04	19	41	2	7558022
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATP6V1A GRIK2 OLFM2 SMG7 SELENON SLC38A9 SNX29 PIK3R3	2.99e-04	1489	41	8	28611215
Pubmed	Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.	GLUD1 GLUD2	3.09e-04	22	41	2	26767982
GeneFamily	SH2 domain containing	CRKL PIK3R3	7.24e-03	101	23	2	741
GeneFamily	Fibronectin type III domain containing	IL12RB1 SDK2	1.74e-02	160	23	2	555
Coexpression	GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_HET_UP	SLAMF8 CCSAP SERPINB11 COQ9 LCMT1	1.31e-05	195	41	5	M8724
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OLFM2 CRISPLD1 PIK3R3 AZIN1	2.28e-05	181	41	4	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFM2 CRISPLD1 PIK3R3 AZIN1	2.38e-05	183	41	4	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFM2 CRISPLD1 PIK3R3 AZIN1	2.54e-05	186	41	4	5302399825f213d105ac70b91366a4513b732838
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFM2 CRISPLD1 PIK3R3 AZIN1	2.82e-05	191	41	4	6e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFM2 CRISPLD1 PIK3R3 AZIN1	2.82e-05	191	41	4	482db995930346be69072ace2fd78fd453e97fb5
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLAMF8 LINC00518 SDK2 AEBP1	2.94e-05	193	41	4	df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLAMF8 LINC00518 SDK2 AEBP1	2.94e-05	193	41	4	ab36d684bde8fe77d11a5188425135328052c58b
Drug	phenyltriethoxysilane	GLUD1 GLUD2	3.01e-06	2	40	2	CID000013075
Drug	methylmercuric bromide	GLUD1 GLUD2	3.01e-06	2	40	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	3.01e-06	2	40	2	CID000068137
Drug	G-3SH	GLUD1 GLUD2	3.01e-06	2	40	2	CID000174237
Drug	x 1 s	GLUD1 GLUD2	3.01e-06	2	40	2	CID000409694
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	3.01e-06	2	40	2	CID006455327
Drug	methoxyethylmercury	GLUD1 GLUD2	9.02e-06	3	40	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	9.02e-06	3	40	2	CID000600674
Drug	lenthionine	GLUD1 GLUD2	9.02e-06	3	40	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	9.02e-06	3	40	2	CID000125665
Drug	methylmercuric iodide	GLUD1 GLUD2	9.02e-06	3	40	2	CID000067347
Drug	methyl benzoquate	GLUD1 GLUD2	1.80e-05	4	40	2	CID000026383
Drug	8-BDB-TADP	GLUD1 GLUD2	1.80e-05	4	40	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	1.80e-05	4	40	2	CID000010657
Drug	luxabendazole	GLUD1 GLUD2	1.80e-05	4	40	2	CID000072019
Drug	AC1L9CUQ	GLUD1 GLUD2	1.80e-05	4	40	2	CID000442451
Drug	ureidoglycine	GLUD1 GLUD2	1.80e-05	4	40	2	CID000439649
Drug	N-butylmaleimide	GLUD1 GLUD2	1.80e-05	4	40	2	CID000239780
Drug	Ivin	GLUD1 GLUD2	1.80e-05	4	40	2	CID000014083
Drug	alpha-methylglutamate	GLUD1 GLUD2	1.80e-05	4	40	2	CID000095440
Drug	pentenoic acid	GLUD1 GLUD2	1.80e-05	4	40	2	CID000012299
Drug	2b E2	GLUD1 GLUD2	1.80e-05	4	40	2	CID005327076
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	1.80e-05	4	40	2	CID000000048
Drug	1-pheg	GLUD1 GLUD2	3.00e-05	5	40	2	CID000152041
Drug	bathocuproine	GLUD1 GLUD2	3.00e-05	5	40	2	CID000065149
Drug	choline sulfate	GLUD1 GLUD2	3.00e-05	5	40	2	CID000000485
Drug	l-413	GLUD1 GLUD2	3.00e-05	5	40	2	CID000012475
Drug	5'-FSBAzA	GLUD1 GLUD2	3.00e-05	5	40	2	CID000130430
Drug	adenine N1-oxide	GLUD1 GLUD2	3.00e-05	5	40	2	CID000093557
Drug	AC1NRA4I	GLUD1 GLUD2	3.00e-05	5	40	2	CID005287695
Drug	isosteviol lactone	GLUD1 GLUD2	3.00e-05	5	40	2	CID000401559
Drug	3-aminopicolinate	GLUD1 GLUD2	3.00e-05	5	40	2	CID000073836
Drug	richter	GLUD1 MYBL1 GLUD2	4.06e-05	38	40	3	CID003032626
Drug	alpha-monofluoromethylputrescine	GLUD1 GLUD2	4.49e-05	6	40	2	CID000134201
Drug	dadAB	GLUD1 GLUD2	4.49e-05	6	40	2	CID000022626
Drug	N-methylhydantoin	GLUD1 GLUD2	4.49e-05	6	40	2	CID000069217
Drug	Emid	GLUD1 GLUD2	4.49e-05	6	40	2	CID000074798
Drug	dimethylmalonate	GLUD1 GLUD2	4.49e-05	6	40	2	CID000007943
Drug	AC1L8SA5	GLUD1 GLUD2	4.49e-05	6	40	2	CID000407285
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	GLUD1 GLUD2	4.49e-05	6	40	2	CID000015362
Drug	diazonium-1-H-tetrazole	GLUD1 GLUD2	4.49e-05	6	40	2	CID000188312
Drug	lanosol	GLUD1 GLUD2	4.49e-05	6	40	2	CID000078659
Drug	AC1L448Y	GLUD1 GLUD2	4.49e-05	6	40	2	CID000200389
Drug	2-BDB-TAMP	GLUD1 GLUD2	4.49e-05	6	40	2	CID000127220
Drug	isodiazinon	GLUD1 GLUD2	4.49e-05	6	40	2	CID000133913
Drug	carbophenothion	GLUD1 GLUD2	6.28e-05	7	40	2	CID000013081
Drug	37474A	GLUD1 GLUD2	6.28e-05	7	40	2	CID004330138
Drug	AC1L1B5W	GLUD1 GLUD2	6.28e-05	7	40	2	CID000001296
Drug	2-oxoglutaconic acid	GLUD1 GLUD2	6.28e-05	7	40	2	CID006443759
Drug	d-serine methyl ester hydrochloride	GLUD1 GLUD2	6.28e-05	7	40	2	CID000090387
Drug	2'(3')-O-(2,4,6-trinitrophenyl)-ADP	GLUD1 GLUD2	8.37e-05	8	40	2	CID000644359
Drug	6-chloroquinoxaline-2,3-diol	GLUD1 GLUD2	8.37e-05	8	40	2	CID000081143
Drug	Nessler's reagent	GLUD1 GLUD2	8.37e-05	8	40	2	CID000024542
Drug	2-heptanol	GLUD1 GLUD2	8.37e-05	8	40	2	CID000010976
Drug	iminoglutarate	GLUD1 GLUD2	8.37e-05	8	40	2	CID000152649
Drug	bidisomide	GLUD1 GLUD2	8.37e-05	8	40	2	CID000059798
Drug	Pheg	GLUD1 GLUD2	8.37e-05	8	40	2	CID003080746
Drug	AC1MQ2IK	GLUD1 GLUD2	8.37e-05	8	40	2	CID003394958
Drug	AC1N690Y	GLUD1 GLUD2	8.37e-05	8	40	2	CID004256264
Drug	trimethyllead chloride	GLUD1 GLUD2	8.37e-05	8	40	2	CID000223969
Drug	NHS-ASA	GLUD1 GLUD2	1.08e-04	9	40	2	CID003035647
Drug	DCQX	GLUD1 GLUD2	1.08e-04	9	40	2	CID000001845
Drug	adipamide	GLUD1 GLUD2	1.08e-04	9	40	2	CID000012364
Drug	temelastine	GLUD1 GLUD2	1.08e-04	9	40	2	CID000055482
Drug	dimethyl L-glutamate	GLUD1 GLUD2	1.08e-04	9	40	2	CID000093032
Drug	Asparagusate	GLUD1 GLUD2	1.08e-04	9	40	2	CID000016682
Drug	AC1L1GWH	GLUD1 GLUD2	1.08e-04	9	40	2	CID000003872
Drug	AC1N4HBY	GLUD1 GLUD2	1.08e-04	9	40	2	CID004128835
Drug	bis-NAD	GLUD1 GLUD2	1.34e-04	10	40	2	CID003081557
Drug	NmiQ	GLUD1 GLUD2	1.34e-04	10	40	2	CID000019850
Drug	S884	GLUD1 GLUD2	1.34e-04	10	40	2	CID004685067
Drug	diglycerol	GLUD1 GLUD2	1.34e-04	10	40	2	CID000042953
Drug	ED20	SLC10A2 GLUD1 GLUD2	1.45e-04	58	40	3	CID000062790
Drug	kievitone	GLUD1 GLUD2	1.64e-04	11	40	2	CID000119269
Drug	AC1O3MP2	GLUD1 GLUD2	1.64e-04	11	40	2	CID006332324
Drug	sulfoacetic acid	GLUD1 GLUD2	1.64e-04	11	40	2	CID000031257
Drug	ADP-ribosylcysteine	GLUD1 GLUD2	1.64e-04	11	40	2	CID003035804
Drug	5-ethylphenazin-5-ium	GLUD1 GLUD2	1.64e-04	11	40	2	CID000082689
Drug	nitroparacetamol	GLUD1 GLUD2	1.96e-04	12	40	2	CID006918532
Drug	5'-deoxypyridoxal	GLUD1 GLUD2	1.96e-04	12	40	2	CID000164889
Drug	Methylthioacetylaminoethanol	GLUD1 GLUD2	1.96e-04	12	40	2	CID000155653
Drug	AC1O3Q5W	GLUD1 GLUD2	1.96e-04	12	40	2	CID006334250
Drug	phylloerythrin	GLUD1 GLUD2	2.32e-04	13	40	2	CID005480977
Drug	rafoxanide	GLUD1 GLUD2	2.32e-04	13	40	2	CID000031475
Drug	butanetetracarboxylic acid	GLUD1 GLUD2	2.32e-04	13	40	2	CID000015560
Drug	Pandurol	GLUD1 GLUD2	2.32e-04	13	40	2	CID000019618
Drug	N-carbamylglutamate	GLUD1 GLUD2	2.32e-04	13	40	2	CID000121396
Drug	AlaGlu	GLUD1 GLUD2	2.32e-04	13	40	2	CID000128841
Drug	5-hydroxythiabendazole	GLUD1 GLUD2	2.32e-04	13	40	2	CID000108227
Drug	TNP-GTP	GLUD1 GLUD2	2.32e-04	13	40	2	CID000126171
Drug	2N3NAD	GLUD1 GLUD2	2.32e-04	13	40	2	CID000164223
Drug	sporidesmin	GLUD1 GLUD2	2.32e-04	13	40	2	CID000099596
Drug	2-oxohexanoate	GLUD1 GLUD2	2.32e-04	13	40	2	CID000159664
Drug	dimethyl suberimidate	RENBP GLUD1 GLUD2	2.33e-04	68	40	3	CID000034750
Drug	L-Glutamic Acid	GRIK2 GLUD1 GLUD2	2.33e-04	68	40	3	DB00142
Drug	alpha-methylisocitrate	GLUD1 GLUD2	2.70e-04	14	40	2	CID000000513
Drug	ws 10	GLUD1 GLUD2	2.70e-04	14	40	2	CID000107151
Drug	Tdagp	GLUD1 GLUD2	2.70e-04	14	40	2	CID005491936
Drug	C10E5	BRD2 RBL2	2.70e-04	14	40	2	CID000168092
Drug	epsilon NAD	GLUD1 GLUD2	2.70e-04	14	40	2	CID000170119
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	5.10e-06	3	39	2	DOID:885 (biomarker_via_orthology)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	2.54e-05	6	39	2	DOID:1825 (biomarker_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	1.77e-04	15	39	2	DOID:13413 (biomarker_via_orthology)
Disease	lifestyle measurement, alcohol consumption measurement	GRIK2 BRINP1 SNX29	4.76e-04	115	39	3	EFO_0007878, EFO_0010724
Disease	temporal lobe epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	7.73e-04	31	39	2	DOID:3328 (biomarker_via_orthology)
Disease	lifestyle measurement, anxiety disorder measurement	GRIK2 BRINP1 SNX29	7.92e-04	137	39	3	EFO_0007795, EFO_0010724
Disease	Adult Medulloblastoma	BRD3 BRD2	1.49e-03	43	39	2	C0278876
Disease	Childhood Medulloblastoma	BRD3 BRD2	1.49e-03	43	39	2	C0278510
Disease	Melanotic medulloblastoma	BRD3 BRD2	1.49e-03	43	39	2	C1275668
Disease	Medullomyoblastoma	BRD3 BRD2	1.49e-03	43	39	2	C0205833
Disease	Desmoplastic Medulloblastoma	BRD3 BRD2	1.49e-03	43	39	2	C0751291
Disease	Gastric Adenocarcinoma	BRD3 BRD2	1.63e-03	45	39	2	C0278701
Disease	Medulloblastoma	BRD3 BRD2	2.00e-03	50	39	2	C0025149

Protein segments in the cluster

Peptide	Gene	Start	Entry
WSASECMQDFNTMFT	BRD3	96	Q15059
MEYTLANMAKSWAEA	BRINP1	286	O60477
DWYEMQDAGITSDSM	AZIN1	411	O14977
DSQTWVMYTNGYEEM	AEBP1	481	Q8IUX7
MDSSDETGSSFMSFW	LINC00518	1	Q8N0U6
ASSSENPWMTEYMRC	CCSAP	251	Q6IQ19
TMAPSADSRVWYMDG	OLFM2	221	O95897
AARAEAWDSYRSMSE	RBL2	61	Q08999
CYMDYSMVATVSSEW	APLNR	181	P35414
FYTMAMNELWRATGE	RENBP	136	P51606
MSSARFDSSDRSAWY	CRKL	1	P46109
GSSFEMASNTDMRWD	FAM170B	151	A6NMN3
GTSRWSSMEIMEAYS	KCNAB2	186	Q13303
MYNTVWSMDRDDADW	PIK3R3	1	Q92569
ENGWMSYLSEMSTSC	GLP2R	246	O95838
MSTGEREMSWIADTY	GLUD1	226	P00367
SNMEYMTWDVELERS	CRISPLD1	81	Q9H336
MATYSWSRESGAMGQ	IL12RB1	396	P42701
MSTAWDLYDSYNAME	DNAI4	316	Q5VTH9
TSMVDDMWHYAGDQS	COQ9	221	O75208
TYDKMWAFMSSRRQS	GRIK2	701	Q13002
GATWAELTSMYSMRN	SDK2	1561	Q58EX2
SRTMMFSLDTTSWEY	SLC38A9	171	Q8NBW4
MNTGEREMSWIADTY	GLUD2	226	P49448
SWSGSFLMDDNMSNT	MYBL1	296	P10243
AYWVDGDMDLSVSMT	SLC10A2	116	Q12908
ADMWASTFTLAMAER	RTP5	6	Q14D33
WGANYMDCFESNETM	RPE65	271	Q16518
MTDTVFSNSSNRWMY	RPH3A	1	Q9Y2J0
YEDWSFVMDEERSSM	SNX29	146	Q8TEQ0
NGWETASAVDMMELY	LCMT1	271	Q9UIC8
WDSSYSMADNRSVMA	SMG7	871	Q92540
DADALGSMLISWYMS	SMN1	256	Q16637
GTFHEWTSSSNMMER	SERPINB11	266	Q96P15
WAASECMQDFNTMFT	BRD2	136	P25440
LVRSFWSDMMDSAQS	TMEM59	146	Q9BXS4
WSDMMDSAQSFITSS	TMEM59	151	Q9BXS4
VDMEWLYGASESSNM	SELENON	341	Q9NZV5
CYEANRMAWMTSDVF	TIGD4	251	Q8IY51
GYHVSMMADSTSRWA	ATP6V1A	341	P38606
TYSWRRETTMDFGME	SLAMF8	161	Q9P0V8
SSMMDVQADWYGEDS	ZBTB8B	316	Q8NAP8