Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5B KDM5C KDM5D

4.38e-076573GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5B KDM5C KDM5D

1.22e-068573GO:0032453
GeneOntologyMolecularFunctionactin filament binding

MYH6 MYH7 NEBL ITPRID2 NEB MYO15A

4.52e-05227576GO:0051015
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5B KDM5C KDM5D

6.87e-0528573GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5B KDM5C KDM5D

9.37e-0531573GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5B KDM5C KDM5D

1.03e-0432573GO:0140457
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH6 MYH7 MYO15A

1.73e-0438573GO:0000146
GeneOntologyMolecularFunctionstructural constituent of muscle

NEBL OBSCN NEB

2.51e-0443573GO:0008307
GeneOntologyMolecularFunctiondemethylase activity

KDM5B KDM5C KDM5D

2.69e-0444573GO:0032451
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5B KDM5C KDM5D

8.50e-0465573GO:0016706
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

KDM5B CYP2F1 KDM5C KDM5D

2.28e-03194574GO:0016705
GeneOntologyMolecularFunctionactin binding

MYH6 MYH7 NEBL ITPRID2 NEB MYO15A

2.38e-03479576GO:0003779
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

MAP3K15 MAP3K5

2.68e-0327572GO:0004709
GeneOntologyMolecularFunctiondioxygenase activity

KDM5B KDM5C KDM5D

2.77e-0398573GO:0051213
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYH6 MYH7 ANK3 NEBL OBSCN TOGARAM1 ITPRID2 NEB MYO15A

3.71e-031099579GO:0008092
GeneOntologyMolecularFunctionhistone modifying activity

KDM5B KDM5C SETBP1 KDM5D

4.14e-03229574GO:0140993
GeneOntologyMolecularFunctioncalmodulin binding

MYH6 MYH7 OBSCN MYO15A

4.20e-03230574GO:0005516
GeneOntologyBiologicalProcessmyofibril assembly

MYH6 MYH7 NEBL OBSCN NEB

3.62e-0686565GO:0030239
GeneOntologyBiologicalProcessstriated muscle cell development

MYH6 MYH7 NEBL OBSCN NEB

4.29e-0689565GO:0055002
GeneOntologyBiologicalProcesssarcomere organization

MYH6 MYH7 OBSCN NEB

1.98e-0559564GO:0045214
GeneOntologyBiologicalProcesscardiac muscle thin filament assembly

NEBL NEB

2.17e-053562GO:0071691
GeneOntologyBiologicalProcessnegative regulation of immune response

TRAFD1 ABR INPP5D SERPING1 IFI16 STAT6

4.55e-05239566GO:0050777
GeneOntologyBiologicalProcessactin cytoskeleton organization

MYH6 MYH7 ABR NEBL NCKAP1 AMOTL1 OBSCN NEB MYO15A KIT

5.30e-058035610GO:0030036
GeneOntologyBiologicalProcesscellular anatomical entity morphogenesis

MYH6 MYH7 NEBL OBSCN NEB

6.50e-05156565GO:0032989
GeneOntologyBiologicalProcesscellular component assembly involved in morphogenesis

MYH6 MYH7 NEBL OBSCN NEB

6.50e-05156565GO:0010927
GeneOntologyBiologicalProcessmuscle cell differentiation

MYH6 TSHZ3 MYH7 NEBL OBSCN LAMA2 NEB KIT

8.77e-05531568GO:0042692
GeneOntologyBiologicalProcessuterus morphogenesis

KDM5B NIPBL

1.08e-046562GO:0061038
GeneOntologyBiologicalProcessanimal organ morphogenesis

KDM5B MYH6 TSHZ3 MYH7 ABR NCKAP1 APCDD1 LAMA2 ZMIZ1 MYO15A NIPBL STAT6

1.25e-0412695612GO:0009887
GeneOntologyBiologicalProcessactin filament-based process

MYH6 MYH7 ABR NEBL NCKAP1 AMOTL1 OBSCN NEB MYO15A KIT

1.52e-049125610GO:0030029
GeneOntologyBiologicalProcessestablishment or maintenance of cytoskeleton polarity

ANK3 NCKAP1

2.57e-049562GO:0030952
GeneOntologyBiologicalProcessmast cell proliferation

KIT STAT6

2.57e-049562GO:0070662
GeneOntologyBiologicalProcessregulation of mast cell proliferation

KIT STAT6

2.57e-049562GO:0070666
GeneOntologyBiologicalProcessmuscle structure development

MYH6 TSHZ3 MYH7 NEBL OBSCN LAMA2 NEB KIT MAP3K5

4.67e-04858569GO:0061061
GeneOntologyBiologicalProcessactomyosin structure organization

MYH6 MYH7 NEBL OBSCN NEB

4.73e-04239565GO:0031032
GeneOntologyCellularComponentZ disc

MYH6 MYH7 ANK3 NEBL OBSCN NEB

3.10e-06151566GO:0030018
GeneOntologyCellularComponentI band

MYH6 MYH7 ANK3 NEBL OBSCN NEB

5.35e-06166566GO:0031674
GeneOntologyCellularComponentmyofibril

MYH6 MYH7 ANK3 NEBL AHNAK OBSCN NEB

8.06e-06273567GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

MYH6 MYH7 ANK3 NEBL AHNAK OBSCN NEB

1.19e-05290567GO:0043292
GeneOntologyCellularComponentmyosin filament

MYH6 MYH7 OBSCN

4.02e-0525563GO:0032982
GeneOntologyCellularComponentsarcomere

MYH6 MYH7 ANK3 NEBL OBSCN NEB

5.30e-05249566GO:0030017
GeneOntologyCellularComponentactin cytoskeleton

MYH6 MYH7 NEBL NCKAP1 INPP5D AHNAK NEB MYO15A

1.40e-04576568GO:0015629
GeneOntologyCellularComponentsupramolecular fiber

MYH6 MYH7 EFCAB6 ANK3 NEBL NCKAP1 INPP5D AHNAK OBSCN TOGARAM1 NEB

2.50e-0411795611GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

MYH6 MYH7 EFCAB6 ANK3 NEBL NCKAP1 INPP5D AHNAK OBSCN TOGARAM1 NEB

2.65e-0411875611GO:0099081
GeneOntologyCellularComponentmyosin complex

MYH6 MYH7 MYO15A

5.32e-0459563GO:0016459
GeneOntologyCellularComponentmuscle myosin complex

MYH6 MYH7

8.26e-0416562GO:0005859
GeneOntologyCellularComponentcostamere

ANK3 AHNAK

1.57e-0322562GO:0043034
GeneOntologyCellularComponentsarcolemma

ANK3 AHNAK OBSCN LAMA2

1.68e-03190564GO:0042383
GeneOntologyCellularComponentcell-cell contact zone

ANK3 AHNAK OBSCN

2.05e-0394563GO:0044291
GeneOntologyCellularComponentmyosin II complex

MYH6 MYH7

2.55e-0328562GO:0016460
GeneOntologyCellularComponentcontractile actin filament bundle

MYH6 MYH7 NEBL

2.97e-03107563GO:0097517
GeneOntologyCellularComponentstress fiber

MYH6 MYH7 NEBL

2.97e-03107563GO:0001725
GeneOntologyCellularComponentmyofilament

OBSCN NEB

3.32e-0332562GO:0036379
GeneOntologyCellularComponentactomyosin

MYH6 MYH7 NEBL

3.82e-03117563GO:0042641
GeneOntologyCellularComponentactin filament bundle

MYH6 MYH7 NEBL

3.91e-03118563GO:0032432
GeneOntologyCellularComponentanchoring junction

ANK3 NCKAP1 AHNAK AMOTL1 OBSCN GIT2 KIT ADCYAP1R1

4.26e-03976568GO:0070161
GeneOntologyCellularComponentcell-cell junction

ANK3 AHNAK AMOTL1 OBSCN KIT ADCYAP1R1

4.88e-03591566GO:0005911
GeneOntologyCellularComponentbicellular tight junction

ANK3 AMOTL1 ADCYAP1R1

5.23e-03131563GO:0005923
GeneOntologyCellularComponenttight junction

ANK3 AMOTL1 ADCYAP1R1

6.17e-03139563GO:0070160
DomainLys_sp_deMease-like_dom

KDM5B KDM5C KDM5D

1.08e-074573IPR013637
DomainPLU-1

KDM5B KDM5C KDM5D

1.08e-074573PF08429
Domainzf-C5HC2

KDM5B KDM5C KDM5D

2.68e-075573PF02928
DomainZnf_C5HC2

KDM5B KDM5C KDM5D

2.68e-075573IPR004198
DomainJmjN

KDM5B KDM5C KDM5D

3.19e-0610573SM00545
DomainJMJN

KDM5B KDM5C KDM5D

3.19e-0610573PS51183
DomainJmjN

KDM5B KDM5C KDM5D

3.19e-0610573PF02375
DomainJmjN

KDM5B KDM5C KDM5D

3.19e-0610573IPR003349
Domain-

KDM5B KDM5C KDM5D

1.19e-05155731.10.150.60
DomainBRIGHT

KDM5B KDM5C KDM5D

1.19e-0515573SM00501
DomainARID_dom

KDM5B KDM5C KDM5D

1.19e-0515573IPR001606
DomainARID

KDM5B KDM5C KDM5D

1.19e-0515573PS51011
DomainARID

KDM5B KDM5C KDM5D

1.19e-0515573PF01388
DomainDUF4071

MAP3K15 MAP3K5

2.74e-053572IPR025136
DomainDUF4071

MAP3K15 MAP3K5

2.74e-053572PF13281
DomainJmjC

KDM5B KDM5C KDM5D

5.21e-0524573PF02373
DomainNEBU

NEBL NEB

5.47e-054572SM00227
DomainNebulin

NEBL NEB

5.47e-054572PF00880
DomainNebulin

NEBL NEB

5.47e-054572IPR013998
DomainNEBULIN

NEBL NEB

5.47e-054572PS51216
DomainNebulin_repeat

NEBL NEB

5.47e-054572IPR000900
DomainIQ

MYH6 MYH7 OBSCN MYO15A

1.09e-0481574SM00015
DomainJMJC

KDM5B KDM5C KDM5D

1.26e-0432573PS51184
DomainJmjC_dom

KDM5B KDM5C KDM5D

1.26e-0432573IPR003347
DomainJmjC

KDM5B KDM5C KDM5D

1.38e-0433573SM00558
DomainIQ_motif_EF-hand-BS

MYH6 MYH7 OBSCN MYO15A

1.64e-0490574IPR000048
DomainIQ

MYH6 MYH7 OBSCN MYO15A

1.86e-0493574PS50096
DomainMyosin_head_motor_dom

MYH6 MYH7 MYO15A

2.11e-0438573IPR001609
DomainMYOSIN_MOTOR

MYH6 MYH7 MYO15A

2.11e-0438573PS51456
DomainMyosin_head

MYH6 MYH7 MYO15A

2.11e-0438573PF00063
DomainMYSc

MYH6 MYH7 MYO15A

2.11e-0438573SM00242
DomainMyosin_N

MYH6 MYH7

9.37e-0415572PF02736
DomainMyosin_N

MYH6 MYH7

9.37e-0415572IPR004009
DomainZinc_finger_PHD-type_CS

KDM5B KDM5C KDM5D

1.03e-0365573IPR019786
Domain-

EFCAB6 C1orf87 FSTL4 FLG2 STAT6

1.19e-032615751.10.238.10
DomainIQ

MYH6 OBSCN MYO15A

1.33e-0371573PF00612
DomainMyosin_tail_1

MYH6 MYH7

1.36e-0318572PF01576
DomainMyosin_tail

MYH6 MYH7

1.36e-0318572IPR002928
DomainMyosin-like_IQ_dom

MYH6 MYH7

1.51e-0319572IPR027401
Domain-

MYH6 MYH7

1.51e-03195724.10.270.10
DomainPHD

KDM5B KDM5C KDM5D

1.56e-0375573PF00628
DomainEF-hand-dom_pair

EFCAB6 C1orf87 FSTL4 FLG2 STAT6

1.80e-03287575IPR011992
DomainZnf_PHD-finger

KDM5B KDM5C KDM5D

1.81e-0379573IPR019787
DomainPHD

KDM5B KDM5C KDM5D

2.54e-0389573SM00249
DomainZnf_PHD

KDM5B KDM5C KDM5D

2.71e-0391573IPR001965
DomainZF_PHD_2

KDM5B KDM5C KDM5D

3.06e-0395573PS50016
DomainZF_PHD_1

KDM5B KDM5C KDM5D

3.15e-0396573PS01359
DomainSH3

NEBL OBSCN NEB MYO15A

4.26e-03216574SM00326
DomainSH3

NEBL OBSCN NEB MYO15A

4.26e-03216574PS50002
DomainSH3_domain

NEBL OBSCN NEB MYO15A

4.54e-03220574IPR001452
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5B KDM5C KDM5D

7.92e-0529413MM14934
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5B KDM5C KDM5D

1.67e-08457316541399
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5B KDM5C KDM5D

1.67e-08457317320160
Pubmed

Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.

MYH6 MYH7 PCM1

6.82e-071157331286143
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5B KDM5C KDM5D

1.18e-061357324619213
Pubmed

Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.

MYH6 MYH7

2.64e-06257221526716
Pubmed

SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo.

INPP5D KIT

2.64e-06257219542434
Pubmed

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.

MYH6 MYH7

2.64e-06257218480046
Pubmed

Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation.

APCDD1 LAMA2

2.64e-06257236098369
Pubmed

Murine pulmonary myocardium: developmental analysis of cardiac gene expression.

MYH6 MYH7

2.64e-0625727919499
Pubmed

Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice.

KIT STAT6

2.64e-06257212780683
Pubmed

Alcohol-associated fibrosis in females is mediated by female-specific activation of lysine demethylases KDM5B and KDM5C.

KDM5B KDM5C

2.64e-06257235468265
Pubmed

Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias.

MYH6 MYH7

2.64e-06257234384224
Pubmed

Characterization of human cardiac myosin heavy chain genes.

MYH6 MYH7

2.64e-0625722726733
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5C KDM5D

2.64e-06257210441747
Pubmed

Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13.

MYH6 MYH7

2.64e-0625722494889
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5C KDM5D

2.64e-06257216416087
Pubmed

Human cardiac myosin heavy chain genes and their linkage in the genome.

MYH6 MYH7

2.64e-0625723037493
Pubmed

β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.

MYH6 MYH7

2.64e-06257221778428
Pubmed

Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6).

MYH6 MYH7

2.64e-0625728307559
Pubmed

Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.

MYH6 MYH7

2.64e-0625722969919
Pubmed

All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac α myosin, β myosin, and fast skeletal muscle myosin.

MYH6 MYH7

2.64e-06257224224850
Pubmed

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils.

INPP5D KIT

2.64e-06257221131429
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5C KDM5D

2.64e-06257232081420
Pubmed

Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.

MYH6 MYH7

2.64e-06257217575272
Pubmed

Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.

MYH6 MYH7

2.64e-06257216088376
Pubmed

Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences.

MYH6 MYH7

2.64e-0625721776652
Pubmed

Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.

MYH6 MYH7

2.64e-0625729884344
Pubmed

Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes.

MYH6 MYH7

2.64e-06257212750067
Pubmed

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.

MYH6 MYH7

2.64e-0625729541509
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5C KDM5D

2.64e-0625729060413
Pubmed

Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.

MYH6 MYH7

2.64e-06257223580644
Pubmed

Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor tyrosine kinase KIT.

INPP5D KIT

2.64e-06257215990278
Pubmed

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.

MYH6 MYH7

2.64e-06257224829265
Pubmed

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

MYH6 MYH7

2.64e-0625722036722
Pubmed

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.

MYH6 MYH7

2.64e-06257225937279
Pubmed

Contribution of the LIM domain and nebulin-repeats to the interaction of Lasp-2 with actin filaments and focal adhesions.

NEBL NEB

2.64e-06257219851499
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5C KDM5D

2.64e-0625727524912
Pubmed

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue.

MYH6 MYH7

2.64e-06257215621050
Pubmed

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.

MYH7 ANK3 NEBL

4.66e-062057333397958
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 KDM5B TSHZ3 ZNF536 AHNAK ZMIZ1 PCM1

5.43e-0641857734709266
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TSHZ3 USF3 ANK3 INPP5D SETBP1 ITPRID2 KDM5D

6.53e-0643057735044719
Pubmed

Endogenous retinoic acid signaling colocalizes with advanced expression of the adult smooth muscle myosin heavy chain isoform during development of the ductus arteriosus.

MYH6 MYH7

7.91e-0635728620598
Pubmed

Kit activates interleukin-4 receptor and effector signal transducer and activator of transcription 6 independent of its cognate ligand in mouse mast cells.

KIT STAT6

7.91e-06357231957000
Pubmed

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.

MYH6 MYH7

7.91e-06357218362229
Pubmed

Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.

MYH6 MYH7

7.91e-0635721939265
Pubmed

Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.

MAP3K15 MAP3K5

7.91e-06357232156783
Pubmed

Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.

MYH6 MYH7

7.91e-06357220923879
Pubmed

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

MYH6 MYH7

7.91e-0635721694848
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5C KDM5D

7.91e-0635727544442
Pubmed

Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function.

KIT STAT6

7.91e-06357216461458
Pubmed

Stat6 regulation of in vivo IL-4 responses.

KIT STAT6

7.91e-06357210679064
Pubmed

ASK family kinases mediate cellular stress and redox signaling to circadian clock.

MAP3K15 MAP3K5

7.91e-06357229555767
Pubmed

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

KDM5B KDM5C

7.91e-06357226645689
Pubmed

Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.

MYH6 MYH7

7.91e-06357218755891
Pubmed

Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.

KDM5B INPP5D

7.91e-06357227584795
Pubmed

Mutation in myosin heavy chain 6 causes atrial septal defect.

MYH6 MYH7

7.91e-06357215735645
Pubmed

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

KDM5B KDM5C

7.91e-06357227214403
Pubmed

IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity.

KIT STAT6

7.91e-06357216129701
Pubmed

SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.

INPP5D SLAMF7

7.91e-06357236749634
Pubmed

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

KDM5B KDM5C

7.91e-06357238230606
Pubmed

Novel myosin mutations for hereditary hearing loss revealed by targeted genomic capture and massively parallel sequencing.

MYH7 MYO15A

7.91e-06357224105371
Pubmed

The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.

MYH6 MYH7

7.91e-06357222966157
Pubmed

Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest.

MYH6 MYH7

7.91e-06357211066038
Pubmed

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.

MYH7 OBSCN PCM1

9.36e-062557338877142
Pubmed

Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.

INPP5D SLAMF7

1.58e-05457225312647
Pubmed

Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4.

KIT STAT6

1.58e-05457218591675
Pubmed

Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function.

KIT STAT6

1.58e-05457212370375
Pubmed

Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.

MYH6 MYH7

1.58e-0545729927321
Pubmed

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

KIT STAT6

1.58e-05457229915289
Pubmed

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.

INPP5D KIT

1.58e-05457221791431
Pubmed

Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.

NEBL NEB

1.58e-05457223985323
Pubmed

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth.

MYH6 MYH7

1.58e-05457225900833
Pubmed

Changes in expression of nonmuscle myosin heavy chain isoforms during muscle and nonmuscle tissue development.

MYH6 MYH7

1.58e-0545728482409
Pubmed

Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.

KIT STAT6

1.58e-05457219955520
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5C KDM5D

1.58e-05457232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5C KDM5D

1.58e-0545727951230
Pubmed

Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.

MYH6 MYH7

1.58e-05457211815426
Pubmed

Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages.

MYH6 MYH7

1.58e-05457228806941
Pubmed

SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21.

SOX21 STAT6

1.58e-05457236335356
Pubmed

Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation.

MYH6 MYH7

1.58e-0545729389458
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ZNF462 MYH7 OBSCN LAMA2 GIT2 NEB MAP3K5

1.66e-0549757723414517
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5B KDM5C KDM5D

2.20e-053357326864203
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 TSHZ3 ZNF536 ZMIZ1 FLG2 NIPBL

2.38e-0535157638297188
Pubmed

Hypertrophic Cardiomyopathy Overview

MYH6 MYH7 OBSCN

2.41e-053457320301725
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ZNF462 ABR ANK3 NCKAP1 GIT2 NIPBL PCM1 MYEF2 MAP3K5

2.52e-0596357928671696
Pubmed

Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance.

KIT STAT6

2.63e-05557215914553
Pubmed

Recruitment of intra- and extracardiac cells into the myocardial lineage during mouse development.

MYH6 MYH7

2.63e-05557212629673
Pubmed

Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.

MYH6 MYH7

2.63e-0555722552320
Pubmed

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.

INPP5D KIT

2.63e-05557220526344
Pubmed

Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation.

KIT STAT6

2.63e-05557219658093
Pubmed

Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure.

MYH6 MYH7

2.63e-05557212933792
Pubmed

MicroRNAs regulate KDM5 histone demethylases in breast cancer cells.

KDM5B KDM5C

2.63e-05557226621457
Pubmed

Developmental regulation of myosin gene expression in mouse cardiac muscle.

MYH6 MYH7

2.63e-0555722277065
Pubmed

Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.

MYH6 MYH7

2.63e-05557224091702
Pubmed

Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.

MYH6 MYH7

2.63e-05557217192267
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

MYH7 AHNAK MUC16 CRYBG1 ZMIZ1 SLC25A51 PCM1

3.25e-0555257710737800
Pubmed

Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.

MYH6 MYH7

3.94e-05657228381556
Pubmed

Murine B cells regulate serum IgE levels in a CD23-dependent manner.

KIT STAT6

3.94e-05657220870945
Pubmed

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

KDM5B KDM5C

3.94e-05657221960634
Pubmed

Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and phosphatidylinositol 3'-kinase.

KIT STAT6

3.94e-05657210452990
Cytoband19q12

TSHZ3 ZNF536

2.84e-042057219q12
CytobandEnsembl 112 genes in cytogenetic band chr19q12

TSHZ3 ZNF536

6.44e-0430572chr19q12
Cytoband14q12

MYH6 MYH7

2.16e-035557214q12
GeneFamilyAT-rich interaction domain containing

KDM5B KDM5C KDM5D

3.83e-0615383418
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5B KDM5C KDM5D

1.68e-0524383485
GeneFamilyMyosin heavy chains

MYH6 MYH7

4.44e-04153821098
GeneFamilyPHD finger proteins

KDM5B KDM5C KDM5D

8.87e-049038388
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K15 MAP3K5

1.15e-0324382654
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ABR OBSCN

8.48e-0366382722
GeneFamilyEF-hand domain containing

EFCAB6 FSTL4 FLG2

1.08e-02219383863
CoexpressionGSE360_DC_VS_MAC_B_MALAYI_LOW_DOSE_UP

MYH6 INPP5D CARS1 KDM5D PCM1 STAT6

4.67e-06199576M5187
CoexpressionVERNOCHET_ADIPOGENESIS

CYP2F1 APCDD1 ADCYAP1R1

9.22e-0619573M2432
CoexpressionVERNOCHET_ADIPOGENESIS

CYP2F1 APCDD1 ADCYAP1R1

1.91e-0524573MM1317
CoexpressionLU_AGING_BRAIN_UP

NEBL AHNAK ITPRID2 IFI16 NIPBL MAP3K5

2.28e-05263576M5547
CoexpressionMCLACHLAN_DENTAL_CARIES_DN

ANK3 NEBL AHNAK KIT

3.10e-0582574M1278
CoexpressionMURARO_PANCREAS_BETA_CELL

TSHZ3 USF3 ABR NEBL NCKAP1 ACLY SETBP1 TOGARAM1 ZMIZ1 PCM1

3.31e-059465710M39169
CoexpressionHELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN

ANK3 SETBP1 ZMIZ1 IFI16 SLC25A51 STAT6

3.37e-05282576M7623
CoexpressionSWEET_LUNG_CANCER_KRAS_DN

MYH6 CYP2F1 AHNAK LAMA2 SERPING1 IFI16 KIT

3.52e-05422577M7396
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP

TRAFD1 ANK3 NEB IFI16 GEN1

4.90e-05183575M2993
CoexpressionGSE22140_GERMFREE_VS_SPF_ARTHRITIC_MOUSE_CD4_TCELL_DN

TRAFD1 INPP5D SERPING1 CRYBG1 STAT6

7.29e-05199575M7645
CoexpressionGSE1432_CTRL_VS_IFNG_6H_MICROGLIA_DN

TRAFD1 CARS1 SERPING1 SLAMF7 STAT6

7.46e-05200575M3405
CoexpressionGSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN

TRAFD1 KDM5C SERPING1 MUC16 IFI16

7.46e-05200575M9588
CoexpressionGSE1432_1H_VS_6H_IFNG_MICROGLIA_DN

CARS1 SERPING1 CRYBG1 SLAMF7 NIPBL

7.46e-05200575M3411
CoexpressionGSE3982_BASOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP

KDM5B GIT2 ITPRID2 ZMIZ1 KIT

7.46e-05200575M5559
CoexpressionMURARO_PANCREAS_DUCTAL_CELL

KDM5B ANK3 APCDD1 AHNAK AMOTL1 SERTAD2 SERPING1 CRYBG1 IFI16 KIT STAT6

8.16e-0512765711M39173
CoexpressionTSENG_IRS1_TARGETS_UP

APCDD1 ACLY CARS1 SERPING1

1.20e-04116574M10427
CoexpressionCHANDRAN_METASTASIS_TOP50_DN

APCDD1 CRYBG1 STAT6

1.21e-0444573M17043
CoexpressionTSENG_IRS1_TARGETS_UP

APCDD1 ACLY CARS1 SERPING1

1.50e-04123574MM688
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

ZNF536 USF3 SOX21 APCDD1 ACLY SETBP1 SERPING1 KIT GEN1 NIPBL PCM1 ADCYAP1R1

9.90e-069895712Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

ZNF536 SOX21 APCDD1 ACLY SETBP1 SERPING1 GIT2 GEN1 NIPBL PCM1 ADCYAP1R1

1.10e-058315711Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500

ZNF536 SOX21 APCDD1 SERPING1 KIT NIPBL PCM1 ADCYAP1R1

5.21e-05498578Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlasNK cells, NK.49CI+.Sp, NK1.1+ CD3- Ly49C/I+, Spleen, avg-3

TSHZ3 AHNAK SETBP1 CRYBG1 ZMIZ1 SLAMF7 KIT

7.39e-05385577GSM538285_500
CoexpressionAtlaskidney_adult_Mesangium_Meis_k-means-cluster#4_top-relative-expression-ranked_500

AHNAK SERPING1 IFI16

1.69e-0440573gudmap_kidney_adult_Mesangium_Meis_k4_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

USF3 ACLY SETBP1 GEN1 NIPBL PCM1

1.82e-04311576Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#5

APCDD1 SERPING1 KIT ADCYAP1R1

1.96e-04107574Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K5
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

MYH6 MYH7 ANK3 NEBL OBSCN LAMA2

1.59e-07190576fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

MYH6 MYH7 ANK3 NEBL OBSCN LAMA2

1.64e-0719157625f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NEBL NCKAP1 MUC16 FLG2 MYO15A ADCYAP1R1

1.85e-07195576d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NEBL NCKAP1 MUC16 FLG2 MYO15A ADCYAP1R1

1.85e-0719557619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 ANK3 NEBL OBSCN LAMA2

1.85e-0719557675fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK3 NEBL CYP2F1 AHNAK MUC16 PCM1

2.03e-07198576d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 NEBL OBSCN LAMA2

2.59e-061705753f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN NEB

2.75e-06172575ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN NEB

2.75e-06172575bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK3 NCKAP1 CYP2F1 AHNAK MUC16

2.91e-0617457542f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 NEBL OBSCN LAMA2

3.07e-061765759df7a124ebafb0087da0cda133a394275d7bed81
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 ZNF536 APCDD1 LAMA2 ABCA10

3.16e-061775759ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 ZNF536 APCDD1 LAMA2 ABCA10

3.16e-06177575016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 NEBL OBSCN LAMA2

3.52e-06181575719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

MYH7 ANK3 NEBL OBSCN LAMA2

3.82e-06184575ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 NEBL OBSCN LAMA2

3.92e-06185575549eeb521c3985bff396ea0f202db21822efa51f
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX21 ANK3 CYP2F1 AHNAK MUC16

4.13e-06187575f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYH6 ANK3 NEBL OBSCN NEB

4.24e-061885756d249fe92d51a19da19ec14bb2262d394255d577
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 LAMA2 SERPING1 ADCYAP1R1

4.35e-0618957529287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 LAMA2 SERPING1 ADCYAP1R1

4.35e-061895757150dad9a92a715487c2d8130fa01b752ea69663
ToppCellfacs-Heart-LA/RA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 ANK3 NEBL OBSCN

4.35e-06189575a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 LAMA2 SERPING1 ADCYAP1R1

4.35e-061895756e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellfacs-Heart-LA/RA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 ANK3 NEBL OBSCN

4.35e-06189575efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

MYH7 ANK3 NEBL OBSCN LAMA2

4.46e-0619057593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

MYH6 MYH7 ANK3 NEBL OBSCN

4.70e-06192575ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 ANK3 NEBL OBSCN

4.82e-06193575dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYH6 ZNF536 ANK3 NEBL OBSCN

4.94e-0619457589812fb164065041357bb37a3c2d87028ec3de4e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 APCDD1 SETBP1 LAMA2 ABCA10

5.32e-06197575ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ3 APCDD1 SETBP1 LAMA2 ABCA10

5.32e-0619757537f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCKAP1 CYP2F1 AHNAK MUC16 CRYBG1

5.32e-061975755c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 CYP2F1 ITPRID2 IFI16 KIT

5.59e-0619957532bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANK3 NEBL AHNAK MUC16 PCM1

5.73e-0620057564462a18afca3c1a8548a857924b8166058bf958
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AHNAK SERPING1 IFI16 NIPBL PCM1

5.73e-0620057512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANK3 NEBL NCKAP1 AHNAK MUC16

5.73e-06200575ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TSHZ3 ZNF536 APCDD1 LAMA2 ABCA10

5.73e-06200575fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK3 NEBL CYP2F1 MUC16

4.88e-05157574c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZNF536 AMOTL1 FSTL4 KIT

5.38e-051615743b5d7a3dab479c6959a428f3954dedd989900276
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-NK_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ3 AHNAK SLAMF7 KIT

6.20e-05167574aef22535a76e93472bcedacbb2c6991f3c9c8cd5
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2F1 SETBP1 MUC16 MYO15A

6.35e-05168574de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 ABCA10 ADCYAP1R1 MAP3K5

6.35e-051685744b2d29a7843bf45922038c093ca7ec0600756adc
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSHZ3 OBSCN LAMA2 SERPING1

6.35e-05168574d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 OBSCN MAP3K15

6.65e-05170574d99f61aa85ea3f775165cb433421e6f1cda4f96b
ToppCell15-Airway-Epithelial-Club-like_secretory|Airway / Age, Tissue, Lineage and Cell class

SOX21 CYP2F1 MUC16 SLAMF7

6.65e-051705741418031cc4b4a87a48621eb53a3c819cd713ddd0
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 OBSCN MAP3K15

6.65e-05170574615cf9639c66b3fbd984ebe3f345280005d3c38a
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX21 ANK3 CYP2F1 MAP3K15

6.80e-051715746f49537f8d3cf18e65aa999fec32ed347ce2da3e
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX21 ANK3 CYP2F1 MAP3K15

6.80e-05171574ab97ae2b127a585f170f028f1c475cdd1b0cdea5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 ABCA10 ADCYAP1R1 MAP3K5

6.80e-051715745d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCelldroplet-Lung-LUNG-30m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH7 SOX21 ANK3 CYP2F1

7.60e-051765745201f003192c033655ba47f0faf8c47a96eae03d
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMOTL1 LAMA2 SERPING1 ADCYAP1R1

7.94e-051785746d9ecfaeb50d562899380de379ebf7b99fd8adc9
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMOTL1 LAMA2 SERPING1 ADCYAP1R1

7.94e-05178574d3f518cd75b02e85d45cbb9b2eff30f0272512a8
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SETBP1 KDM5D SLAMF7 KIT

8.29e-051805748e96f8646c002768b272359af485dc0ab57e0ccd
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

MYH7 ANK3 NEBL OBSCN

8.66e-05182574287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK SLAMF7 NIPBL PCM1

8.66e-05182574f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 OBSCN NEB MYO15A

9.03e-051845742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 SERPING1 ADCYAP1R1

9.03e-05184574fea4fe648e9749177d0783443dc26a7df5807883
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

APCDD1 SETBP1 LAMA2 ABCA10

9.03e-051845742b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 OBSCN NEB MYO15A

9.03e-05184574ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

INPP5D FSTL4 CRYBG1 KIT

9.03e-0518457433db879e629821fb75684e60f8f0749cf9623bdd
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 OBSCN NEB MYO15A

9.03e-051845742b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 SERPING1 ADCYAP1R1

9.03e-0518457496a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCellfacs-Skin-Skin_Anagen-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 CYP2F1 SERPING1 ADCYAP1R1

9.03e-05184574780eb72da43527f0c72effac3423ec7384f05f20
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2F1 LAMA2 SERPING1 ADCYAP1R1

9.22e-051855748433a337625ff8398520e223ef92bf9bb0beb14c
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2F1 LAMA2 SERPING1 ADCYAP1R1

9.22e-05185574049d793d043d5d434f143025de49dd210d18756c
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2F1 LAMA2 SERPING1 ADCYAP1R1

9.22e-0518557463200c42565eea596f9b00728e70e544b8d50a7f
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK SLAMF7 NIPBL PCM1

9.22e-051855747adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

MYH7 ANK3 NEBL OBSCN

9.22e-051855746baccb26f999145e51b91d94315bf8d4655bef31
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL FSTL4 CRYBG1 MAP3K15

9.61e-05187574f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF462 TRAFD1 ZNF737 SLAMF7

9.61e-05187574a6a112689d1c9049f57935ad9d2f4955538427de
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ZNF536 SETBP1 LAMA2 ABCA10

9.61e-05187574bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 ANK3 PDRG1 KIAA1328

9.81e-051885746468fa95ad0395395301115286f2d8c0df5d3882
ToppCellfacs-Heart-LA/RA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN

9.81e-0518857490dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 ANK3 PDRG1 KIAA1328

9.81e-051885747a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF536 ANK3 PDRG1 KIAA1328

9.81e-051885749cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 NEBL CRYBG1 KIT

9.81e-0518857458ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCellfacs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN

9.81e-05188574f63dfd076ced81013918363282ae25cbbd8948ae
ToppCellfacs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN

9.81e-051885740554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

MYH6 ANK3 NEBL OBSCN

1.00e-041895749c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MYH7 NEBL OBSCN LAMA2

1.00e-041895745e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL SETBP1 FSTL4 CRYBG1

1.00e-041895748ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

APCDD1 LAMA2 SERPING1 ABCA10

1.00e-04189574d531399749409d614adca13d181830c6e3287508
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 NEBL SETBP1 KIAA1328

1.00e-04189574830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ3 LAMA2 SERPING1 ADCYAP1R1

1.00e-041895746b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

MYH7 ANK3 NEBL OBSCN

1.00e-041895740a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ3 LAMA2 SERPING1 ADCYAP1R1

1.00e-04189574344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

INPP5D SETBP1 GEN1 MYEF2

1.02e-04190574374d8fd63c733178acab07682ed1519693efab45
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX21 NEBL CYP2F1 MUC16

1.02e-041905746ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MYH7 NEBL OBSCN LAMA2

1.02e-04190574de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH6 MYH7 OBSCN LAMA2

1.02e-04190574918ad5037881212008f9f69d5df5da91fd01422c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL FSTL4 CRYBG1 KIT

1.02e-04190574b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL SETBP1 FSTL4 CRYBG1

1.02e-041905744836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

APCDD1 LAMA2 SERPING1 ABCA10

1.02e-0419057412992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

MYH6 ANK3 NEBL OBSCN

1.04e-041915745d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 ANK3 OBSCN

1.04e-04191574c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCellLV-02._Fibroblast_II|World / Chamber and Cluster_Paper

APCDD1 LAMA2 SERPING1 ABCA10

1.04e-04191574d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN

1.04e-0419157497fb4232417a39801e87725755fd16a57c250209
ToppCelldroplet-Tongue-nan-3m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM5B SOX21 CYP2F1 AHNAK

1.04e-04191574abdd93b2313e635f75a750d051a6a01ddc4e2df9
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 NEBL OBSCN

1.04e-0419157464070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH6 MYH7 ANK3 OBSCN

1.04e-04191574715f5b449b8e075959c05a5b38389df319663164
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

ANK3 AHNAK CRYBG1 PCM1

1.06e-0419257447646d7e4990be85072987f92bf18d52f8da752e
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

TSHZ3 SETBP1 LAMA2 ABCA10

1.06e-0419257460b1312e84f6d6448365a952469c506c00b5fe93
ComputationalNeighborhood of CD53

INPP5D GIT2 IFI16 STAT6

8.05e-0558434GNF2_CD53
ComputationalGenes in the cancer module 202.

MYH7 NEBL NEB

1.82e-0428433MODULE_202
ComputationalNeighborhood of VAV1

INPP5D GIT2 STAT6

3.88e-0436433GNF2_VAV1
ComputationalNeighborhood of INPP5D

INPP5D IFI16 STAT6

6.58e-0443433GNF2_INPP5D
ComputationalGenes in the cancer module 387.

MYH7 LAMA2 NEB

9.66e-0449433MODULE_387
ComputationalGenes in the cancer module 329.

MYH7 LAMA2 NEB

1.09e-0351433MODULE_329
DrugCefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; PC3; HT_HG-U133A

ANK3 NEBL SETBP1 GIT2 IFI16 NIPBL

9.22e-061955767394_DN
DrugCefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; PC3; HT_HG-U133A

MYH7 TRAFD1 AHNAK SLAMF7 MYO15A MYEF2

9.50e-061965763696_UP
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5B KDM5C KDM5D

2.59e-084563DOID:0060809 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5B KDM5C KDM5D

3.56e-0616563DOID:0050888 (implicated_via_orthology)
DiseaseCaveolinopathy

MYH6 MYH7

2.12e-054562cv:C5679790
DiseaseCARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1

MYH6 MYH7

2.12e-054562192600
DiseaseCardiomyopathy, Familial Hypertrophic, 1 (disorder)

MYH6 MYH7

2.12e-054562C3495498
DiseaseHypertrophic cardiomyopathy 1

MYH6 MYH7

2.12e-054562cv:C3495498
Diseaseamphetamine abuse (implicated_via_orthology)

MAP3K15 MAP3K5

5.28e-056562DOID:670 (implicated_via_orthology)
Diseaseatrial fibrillation

ZNF462 MYH6 MYH7 NEBL ZMIZ1 PCM1

7.25e-05371566EFO_0000275
DiseaseIdiopathic hypertrophic subaortic stenosis

MYH6 MYH7

7.38e-057562C0700053
DiseaseObstructive asymmetric septal hypertrophy

MYH6 MYH7

7.38e-057562C0597124
DiseaseFamilial dilated cardiomyopathy

MYH6 MYH7 NEBL

8.11e-0544563C0340427
DiseaseCardiomyopathies

MYH6 MYH7 NEBL MAP3K5

1.11e-04130564C0878544
DiseaseCardiomyopathy, Hypertrophic, Familial

MYH6 MYH7

1.26e-049562C0949658
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0080719 (implicated_via_orthology)
DiseaseMuscular dystrophy, limb-girdle, autosomal dominant

MYH6 MYH7

1.58e-0410562cv:C5675009
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH6 MYH7

1.58e-0410562DOID:0111596 (implicated_via_orthology)
DiseaseHypertrophic Cardiomyopathy

MYH6 MYH7 OBSCN

1.76e-0457563C0007194
DiseaseMalignant neoplasm of breast

C1orf87 SETBP1 OBSCN LAMA2 ZMIZ1 KIT GEN1 NIPBL SLC25A51

1.76e-041074569C0006142
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5B TSHZ3 KDM5C KDM5D

2.02e-04152564DOID:0060041 (implicated_via_orthology)
DiseaseParoxysmal atrial fibrillation

ZNF462 MYH6 MYH7 NEBL

2.23e-04156564C0235480
Diseasefamilial atrial fibrillation

ZNF462 MYH6 MYH7 NEBL

2.23e-04156564C3468561
DiseasePersistent atrial fibrillation

ZNF462 MYH6 MYH7 NEBL

2.23e-04156564C2585653
Diseasedistal myopathy (implicated_via_orthology)

MYH6 MYH7

2.31e-0412562DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH6 MYH7

2.31e-0412562DOID:2106 (implicated_via_orthology)
DiseaseAtrial Fibrillation

ZNF462 MYH6 MYH7 NEBL

2.46e-04160564C0004238
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH6 MYH7

2.72e-0413562DOID:397 (implicated_via_orthology)
Diseaseautosomal dominant polycystic kidney disease (is_marker_for)

SERPING1 STAT6

3.17e-0414562DOID:898 (is_marker_for)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH6 MYH7

3.66e-0415562DOID:0050646 (implicated_via_orthology)
Diseaseintellectual disability (implicated_via_orthology)

KDM5B KDM5C KDM5D

3.97e-0475563DOID:1059 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

KDM5B KDM5C KDM5D ADCYAP1R1

5.19e-04195564DOID:1574 (implicated_via_orthology)
DiseasePrimary familial hypertrophic cardiomyopathy

MYH6 MYH7

7.98e-0422562cv:C0949658
DiseaseHypertrophic obstructive cardiomyopathy

MYH6 MYH7

1.03e-0325562C4551472
DiseaseLimb-girdle muscular dystrophy

MYH6 MYH7

1.12e-0326562cv:C0686353
DiseasePrimary familial dilated cardiomyopathy

MYH6 MYH7

1.49e-0330562cv:C0340427
DiseaseHeart Failure, Diastolic

MYH6 MYH7

1.80e-0333562C1135196
DiseasePapillary Renal Cell Carcinoma

ZNF536 KDM5C AHNAK

1.87e-03128563C1306837
DiseaseRenal Cell Carcinoma

ZNF536 KDM5C AHNAK

1.87e-03128563C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

ZNF536 KDM5C AHNAK

1.87e-03128563C1266043
DiseaseChromophobe Renal Cell Carcinoma

ZNF536 KDM5C AHNAK

1.87e-03128563C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

ZNF536 KDM5C AHNAK

1.87e-03128563C1266044

Protein segments in the cluster

PeptideGeneStartEntry
PFPDHELEDMKMKIS

ABR

371

Q12979
EETMDIELPKKYHEM

ABCA10

21

Q8WWZ4
MHFKAPKISMPDVDL

AHNAK

1316

Q09666
MHFKAPKISMPDVDL

AHNAK

1646

Q09666
EMHFKTPKISMPDVD

AHNAK

1981

Q09666
EMHFKTPKISMPDVN

AHNAK

2176

Q09666
LHKPEFPDGEMMEVL

AMOTL1

941

Q8IY63
TEMAALFPKKPKSDM

GIT2

681

Q14161
PEVPEMSQSKTEHMK

C1orf87

411

Q8N0U7
FGNMFIKMPHPETKE

PDRG1

61

Q9NUG6
IKMPHPETKEMIEKD

PDRG1

66

Q9NUG6
KMAEEKEDPLSHFHM

CYP2F1

271

P24903
KIEDMAMLTFLHEPA

MYH7

86

P12883
EFPHSEMTTVMNKDP

MUC16

6771

Q8WXI7
KNPDDPDTVDVIMHM

FLG2

46

Q5D862
SPEHAPAEMYDIMKT

KIT

891

P10721
KVFMKRPDPHEEALM

MYO15A

2601

Q9UKN7
MPVHMVPTELVEKEF

KDM5D

401

Q9BY66
MKEVIPFLKEHMDEV

PCM1

1601

Q15154
PKLTPEEMMDSSTFK

NIPBL

1186

Q6KC79
MMFAHKDPREIDPIV

LAMA2

256

P24043
MPVHMVPTELVEKEF

KDM5B

396

Q9UGL1
LPSMPAAEEMHKNVE

ITPRID2

1201

P28290
PTEKMPQEELHMKEC

KIAA1328

281

Q86T90
ENPLKKMMEEFVPHS

NCKAP1

186

Q9Y2A7
KMMEEFVPHSKSLSD

NCKAP1

191

Q9Y2A7
PMAPAMHSDCIFKKE

ADCYAP1R1

16

P41586
HITEPKMMFAKEQSV

OBSCN

1066

Q5VST9
VHDFKKVLEDTGMPM

EFCAB6

656

Q5THR3
KSDPAVHKVDLETMM

FSTL4

616

Q6MZW2
EHKLKMPPASMRTST

ANK3

2076

Q12955
EFVFKVNHMKVTPMD

APCDD1

361

Q8J025
EPFHFKNSVIKVPMM

SERPING1

311

P05155
PEMEKKIMFHATVAT

IFI16

221

Q16666
PDEVMSFQSHMTLKP

GEN1

481

Q17RS7
KKESQPEMSPALHLM

CRYBG1

756

Q9Y4K1
MFKVGMFKVHPEIPE

MAP3K5

891

Q99683
MFKVHPEIPESMSAE

MAP3K5

896

Q99683
MFKVGMFKIHPEIPE

MAP3K15

861

Q6ZN16
MSKPVDHVKRPMNAF

SOX21

1

Q9Y651
AKMKIPPSEMFLSET

CARS1

681

P49589
TCKEPFPKSDMETHM

TRAFD1

41

O14545
RPMHVKMDDKSVPHE

MYEF2

301

Q9P2K5
MMDSEAHEKRPPILT

SLC25A51

1

Q9H1U9
MKNKHSEQPEPDMIT

INPP5D

391

Q92835
MPKHEDLKDMLEFPA

SUPT5H

451

O00267
KIEDMAMLTFLHEPA

MYH6

86

P13533
PVFKNMADAMRKHPE

ACLY

551

P53396
PFKMDLTELDHIMEV

SERTAD2

296

Q14140
EKKAVMEQFRHLPMP

STAT6

106

P42226
DFHEQPVGMPKMEKV

TMEM131

116

Q92545
MPEMTENETPTKKQH

USF3

1

Q68DE3
KKMENPHSLLTMPDT

SLAMF7

311

Q9NQ25
PMPKTNFHAMEELVK

TSHZ3

601

Q63HK5
MKDKALADPPSMKVH

ZNF536

936

O15090
IHPKEIMENSVKMPS

ZNF462

2451

Q96JM2
KERMPSVTHSPEIMD

TOGARAM1

1231

Q9Y4F4
VPGEDKPMSEMKFHK

SETBP1

636

Q9Y6X0
MAALEKPLSHPMQET

ZMIZ1

931

Q9ULJ6
KPLTMKKHEMVANPS

ZNF737

61

O75373
MPVHMVPTELVEKEF

KDM5C

411

P41229
HMKEPPEVKHAMEVN

NEBL

141

O76041
DKTQVHIMPDTPEIM

NEB

3216

P20929