Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC37A1 CNNM1 GJA3 GJA8 TRPV1 SLC7A13 SLC16A1 ABCB5 SLC35B3 SLC17A8 ATP11C SLC2A13 ANO10 ATP1A2 TMC5 SLC7A6 MFSD4B ITGAV SLC7A10 AQP9 ABCB1 SLC17A6

1.42e-1212895622GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC37A1 CNNM1 GJA3 GJA8 TRPV1 SLC7A13 SLC16A1 ABCB5 SLC35B3 SLC17A8 SLC2A13 ANO10 ATP1A2 TMC5 SLC7A6 MFSD4B ITGAV SLC7A10 AQP9 ABCB1 SLC17A6

2.47e-1211805621GO:0022857
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC37A1 SLC7A13 SLC16A1 ABCB5 SLC35B3 SLC17A8 SLC2A13 ATP1A2 SLC7A6 MFSD4B ABCB1 SLC17A6

6.48e-094775612GO:0022804
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC37A1 SLC7A13 SLC16A1 SLC35B3 SLC17A8 SLC7A6 SLC7A10 ABCB1 SLC17A6

1.16e-07293569GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC37A1 SLC7A13 SLC16A1 SLC35B3 SLC17A8 SLC2A13 SLC7A6 MFSD4B SLC17A6

1.26e-07296569GO:0015291
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC7A13 SLC17A8 SLC7A6 SLC7A10 SLC17A6

1.63e-0671565GO:0015179
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC7A13 SLC16A1 SLC17A8 SLC7A6 SLC7A10 ABCB1 SLC17A6

1.75e-06207567GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC7A13 SLC16A1 SLC17A8 SLC7A6 SLC7A10 ABCB1 SLC17A6

1.81e-06208567GO:0005342
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC7A13 SLC17A8 SLC7A6 SLC7A10 SLC17A6

1.13e-05105565GO:0015171
GeneOntologyMolecularFunctionchannel activity

GJA3 GJA8 TRPV1 SLC17A8 ANO10 TMC5 ITGAV AQP9 SLC17A6

1.41e-05525569GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GJA3 GJA8 TRPV1 SLC17A8 ANO10 TMC5 ITGAV AQP9 SLC17A6

1.44e-05526569GO:0022803
GeneOntologyMolecularFunctionMAP kinase kinase activity

MAP2K1 MAP2K2 MAP2K3

1.65e-0518563GO:0004708
GeneOntologyMolecularFunctionL-glutamate uniporter activity

SLC17A8 SLC17A6

2.31e-053562GO:0140788
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC37A1 SLC17A8 SLC17A6

4.06e-0524563GO:0005315
GeneOntologyMolecularFunctionantiporter activity

SLC37A1 SLC7A13 SLC35B3 SLC7A6 SLC17A6

4.22e-05138565GO:0015297
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC37A1 TRPV1 SLC16A1 SLC17A8 SLC2A13 ANO10 ATP1A2 ITGAV AQP9 SLC17A6

4.28e-057585610GO:0015318
GeneOntologyMolecularFunctiontRNA (cytidine-3-)-methyltransferase activity

METTL2A METTL2B

4.62e-054562GO:0052735
GeneOntologyMolecularFunctionsymporter activity

SLC16A1 SLC17A8 SLC2A13 MFSD4B SLC17A6

6.28e-05150565GO:0015293
GeneOntologyMolecularFunctionmembrane potential driven uniporter activity

SLC17A8 SLC17A6

7.68e-055562GO:0022810
GeneOntologyMolecularFunctionphosphatidylethanolamine flippase activity

ATP11C ABCB1

1.61e-047562GO:0090555
GeneOntologyMolecularFunctionprotein serine/threonine/tyrosine kinase activity

MAP2K1 MAP2K2 MAP2K3

3.10e-0447563GO:0004712
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TRPV1 SLC16A1 SLC17A8 SLC2A13 ANO10 ATP1A2 TMC5 ITGAV SLC17A6

3.33e-04793569GO:0015075
GeneOntologyMolecularFunctiontRNA (cytidine) methyltransferase activity

METTL2A METTL2B

3.43e-0410562GO:0016427
GeneOntologyMolecularFunctionuniporter activity

SLC17A8 SLC17A6

3.43e-0410562GO:0015292
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC16A1 SLC17A8 SLC2A13 SLC17A6

3.47e-04119564GO:0015294
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP11C ANO10 ABCB1

3.95e-0451563GO:0140303
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TRPV1 SLC16A1 SLC17A8 SLC2A13 ANO10 ATP1A2 ITGAV SLC17A6

4.97e-04664568GO:0008324
GeneOntologyMolecularFunctionsodium:phosphate symporter activity

SLC17A8 SLC17A6

5.01e-0412562GO:0005436
GeneOntologyMolecularFunctionMAP-kinase scaffold activity

MAP2K1 MAP2K2

5.91e-0413562GO:0005078
GeneOntologyMolecularFunctionpolyol transmembrane transporter activity

SLC2A13 AQP9

5.91e-0413562GO:0015166
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP11C ABCB1

6.88e-0414562GO:0140333
GeneOntologyMolecularFunctionL-glutamate transmembrane transporter activity

SLC17A8 SLC17A6

7.92e-0415562GO:0005313
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCB5 ABCB1

7.92e-0415562GO:0008559
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCB5 ABCB1

9.04e-0416562GO:0015562
GeneOntologyMolecularFunctionfloppase activity

ATP11C ABCB1

9.04e-0416562GO:0140328
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

SLC16A1 SLC2A13 AQP9

1.00e-0370563GO:1901618
GeneOntologyMolecularFunctionflippase activity

ATP11C ABCB1

1.02e-0317562GO:0140327
GeneOntologyMolecularFunctionphospholipid transporter activity

ATP11C ANO10 ABCB1

1.18e-0374563GO:0005548
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC37A1 SLC17A8 ANO10 SLC17A6

1.35e-03171564GO:0015103
GeneOntologyMolecularFunctionacidic amino acid transmembrane transporter activity

SLC17A8 SLC17A6

1.42e-0320562GO:0015172
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC16A1 SLC17A8 SLC2A13 ATP1A2 SLC17A6

1.53e-03301565GO:0022853
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC17A8 SLC17A6

1.57e-0321562GO:0005326
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPV1 SLC17A8 ANO10 TMC5 ITGAV SLC17A6

1.75e-03459566GO:0005216
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPV1 SLC16A1 SLC17A8 SLC2A13 ATP1A2 ITGAV SLC17A6

1.78e-03627567GO:0022890
GeneOntologyMolecularFunctionchloride channel activity

SLC17A8 ANO10 SLC17A6

1.81e-0386563GO:0005254
GeneOntologyMolecularFunctiongap junction channel activity

GJA3 GJA8

2.22e-0325562GO:0005243
GeneOntologyMolecularFunctionsolute:proton symporter activity

SLC16A1 SLC2A13

2.22e-0325562GO:0015295
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP11C ABCB1

2.79e-0328562GO:0140326
GeneOntologyMolecularFunctionmonoatomic anion channel activity

SLC17A8 ANO10 SLC17A6

3.03e-03103563GO:0005253
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCB5 ATP1A2 ABCB1

3.55e-03109563GO:0042626
GeneOntologyMolecularFunctionchemokine binding

CCR2 ITGAV

3.86e-0333562GO:0019956
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCB5 ABCB1

4.09e-0334562GO:0042910
GeneOntologyMolecularFunctiontRNA methyltransferase activity

METTL2A METTL2B

4.09e-0334562GO:0008175
GeneOntologyMolecularFunctionwide pore channel activity

GJA3 GJA8

4.83e-0337562GO:0022829
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC17A8 ANO10 SLC17A6

5.21e-03125563GO:0015108
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

SLC37A1 SLC35B3

5.36e-0339562GO:0015605
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

MFSD4B AQP9

6.19e-0342562GO:0015144
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

TRPV1 ITGAV

7.39e-0346562GO:0005245
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

GARS1 METTL2A METTL2B

7.70e-03144563GO:0140101
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

MAP2K1 MAP2K2 MAP2K3

7.85e-03145563GO:0004713
GeneOntologyMolecularFunctionABC-type transporter activity

ABCB5 ABCB1

8.35e-0349562GO:0140359
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC17A8 ANO10 SLC17A6

8.77e-03151563GO:0008509
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPV1 SLC17A8 ATP1A2 ITGAV SLC17A6

9.66e-03465565GO:0046873
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

SLC37A1 SLC35B3

1.19e-0259562GO:1901505
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC17A8 ATP1A2 SLC17A6

1.23e-02171563GO:0015081
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

SETD7 METTL2A METTL2B

1.25e-02172563GO:0008757
GeneOntologyBiologicalProcessorganic anion transport

SLC37A1 TRPV1 SLC7A13 SLC16A1 SLC35B3 SLC17A8 ATP1A2 SLC7A6 SLC7A10 AQP9 ABCB1 SLC17A6

8.54e-095155512GO:0015711
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

SLC7A13 SLC16A1 SLC17A8 ATP1A2 SLC7A6 SLC7A10 ABCB1 SLC17A6

1.14e-08163558GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

SLC7A13 SLC16A1 SLC17A8 ATP1A2 SLC7A6 SLC7A10 ABCB1 SLC17A6

1.38e-08167558GO:1903825
GeneOntologyBiologicalProcesscarboxylic acid transport

TRPV1 SLC7A13 SLC16A1 SLC17A8 ATP1A2 SLC7A6 SLC7A10 AQP9 ABCB1 SLC17A6

1.14e-074105510GO:0046942
GeneOntologyBiologicalProcessL-alpha-amino acid transmembrane transport

SLC7A13 SLC17A8 ATP1A2 SLC7A6 SLC7A10 SLC17A6

1.16e-0787556GO:1902475
GeneOntologyBiologicalProcessorganic acid transport

TRPV1 SLC7A13 SLC16A1 SLC17A8 ATP1A2 SLC7A6 SLC7A10 AQP9 ABCB1 SLC17A6

1.19e-074125510GO:0015849
GeneOntologyBiologicalProcessL-amino acid transport

SLC7A13 SLC17A8 ATP1A2 SLC7A6 SLC7A10 SLC17A6

4.22e-07108556GO:0015807
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC7A13 SLC17A8 ATP1A2 SLC7A6 SLC7A10 SLC17A6

7.85e-07120556GO:0003333
GeneOntologyBiologicalProcessdicarboxylic acid transport

TRPV1 SLC7A13 SLC16A1 SLC17A8 ATP1A2 SLC17A6

7.85e-07120556GO:0006835
GeneOntologyBiologicalProcessamino acid transport

TRPV1 SLC7A13 SLC17A8 ATP1A2 SLC7A6 SLC7A10 SLC17A6

8.38e-07195557GO:0006865
GeneOntologyBiologicalProcessL-glutamate transmembrane transport

SLC7A13 SLC17A8 ATP1A2 SLC17A6

2.23e-0635554GO:0015813
GeneOntologyBiologicalProcessacidic amino acid transport

TRPV1 SLC7A13 SLC17A8 ATP1A2 SLC17A6

2.94e-0684555GO:0015800
GeneOntologyBiologicalProcessL-glutamate import

SLC7A13 SLC17A8 ATP1A2 SLC17A6

6.79e-0646554GO:0051938
GeneOntologyBiologicalProcessmonoatomic ion transport

CCR2 CNNM1 TRPV1 SLC16A1 SLC17A8 ATP11C NKAIN1 ANO10 ATP1A2 TMC5 MFSD4B ITGAV ABCB1 SLC17A6

1.04e-0513745514GO:0006811
GeneOntologyBiologicalProcessregulation of Golgi inheritance

MAP2K1 MAP2K2

4.17e-054552GO:0090170
GeneOntologyBiologicalProcessregulation of glutamate uptake involved in transmission of nerve impulse

SLC17A8 ATP1A2

4.17e-054552GO:0051946
GeneOntologyBiologicalProcessregulation of amino acid uptake involved in synaptic transmission

SLC17A8 ATP1A2

4.17e-054552GO:0051941
GeneOntologyBiologicalProcessphosphate ion transport

SLC37A1 SLC17A8 SLC17A6

7.65e-0531553GO:0006817
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC16A1 SLC2A13 ATP1A2 ABCB1

8.55e-0587554GO:0150104
GeneOntologyBiologicalProcessvascular transport

SLC16A1 SLC2A13 ATP1A2 ABCB1

8.93e-0588554GO:0010232
GeneOntologyBiologicalProcessglutamate reuptake

SLC17A8 ATP1A2

1.04e-046552GO:0051935
GeneOntologyBiologicalProcessinorganic anion transport

SLC37A1 SLC17A8 ANO10 ABCB1 SLC17A6

1.17e-04180555GO:0015698
GeneOntologyBiologicalProcesstrachea formation

MAP2K1 MAP2K2

1.45e-047552GO:0060440
GeneOntologyBiologicalProcessgap junction-mediated intercellular transport

GJA3 GJA8

1.45e-047552GO:1990349
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CCR2 TRPV1 SLC16A1 SLC17A8 ATP11C ANO10 ATP1A2 TMC5 ITGAV ABCB1 SLC17A6

1.46e-0411155511GO:0034220
GeneOntologyBiologicalProcessregulation of L-glutamate import across plasma membrane

SLC17A8 ATP1A2

3.10e-0410552GO:0002036
GeneOntologyBiologicalProcessamino acid neurotransmitter reuptake

SLC17A8 ATP1A2

3.10e-0410552GO:0051933
GeneOntologyBiologicalProcessneurotransmitter uptake

SLC17A8 ATP1A2 SLC17A6

3.61e-0452553GO:0001504
GeneOntologyBiologicalProcesschloride transport

SLC17A8 ANO10 ABCB1 SLC17A6

3.78e-04128554GO:0006821
GeneOntologyBiologicalProcessneurotransmitter loading into synaptic vesicle

SLC17A8 SLC17A6

3.78e-0411552GO:0098700
GeneOntologyBiologicalProcessintercellular transport

GJA3 GJA8

3.78e-0411552GO:0010496
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CCR2 SLC17A8 ATP1A2 SLC17A6

4.25e-04132554GO:0035249
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC37A1 SLC17A8 ANO10 SLC17A6

4.49e-04134554GO:0098661
GeneOntologyBiologicalProcessepithelial cell proliferation involved in lung morphogenesis

MAP2K1 MAP2K2

4.53e-0412552GO:0060502
GeneOntologyBiologicalProcesstrachea morphogenesis

MAP2K1 MAP2K2

4.53e-0412552GO:0060439
GeneOntologyBiologicalProcessendoplasmic reticulum membrane organization

LPCAT3 ATL1

5.34e-0413552GO:0090158
GeneOntologyBiologicalProcessERBB2-ERBB3 signaling pathway

MAP2K1 MAP2K2

5.34e-0413552GO:0038133
GeneOntologyBiologicalProcesssodium-dependent phosphate transport

SLC17A8 SLC17A6

5.34e-0413552GO:0044341
GeneOntologyBiologicalProcessneutral amino acid transport

SLC7A13 SLC7A6 SLC7A10

5.51e-0460553GO:0015804
GeneOntologyBiologicalProcessERBB3 signaling pathway

MAP2K1 MAP2K2

6.22e-0414552GO:0038129
GeneOntologyBiologicalProcesscirculatory system process

TRPV1 NPR2 SLC16A1 SLC2A13 ATP1A2 MAP2K1 MAP2K3 ABCB1

6.80e-04733558GO:0003013
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC17A8 ANO10 ABCB1 SLC17A6

7.40e-04153554GO:0098656
GeneOntologyBiologicalProcesssodium ion transport

SLC17A8 NKAIN1 ATP1A2 MFSD4B SLC17A6

8.20e-04275555GO:0006814
GeneOntologyBiologicalProcessstress-activated protein kinase signaling cascade

MAP2K1 MAP2K2 MAP2K3

8.30e-0469553GO:0031098
GeneOntologyBiologicalProcessorganophosphate ester transport

SLC37A1 SLC35B3 ATP11C ABCB1

9.16e-04162554GO:0015748
GeneOntologyBiologicalProcessregulation of Golgi organization

MAP2K1 MAP2K2

1.04e-0318552GO:1903358
GeneOntologyBiologicalProcessL-glutamate import across plasma membrane

SLC17A8 ATP1A2

1.16e-0319552GO:0098712
GeneOntologyBiologicalProcessestablishment of blood-brain barrier

TRPV1 ABCB1

1.16e-0319552GO:0060856
GeneOntologyBiologicalProcessregulation of early endosome to late endosome transport

MAP2K1 MAP2K2

1.29e-0320552GO:2000641
GeneOntologyCellularComponentpericellular basket

SLC17A8 SLC17A6

2.11e-053562GO:1990030
GeneOntologyCellularComponentastrocyte end-foot

SLC17A8 SLC2A13

4.57e-0412562GO:0097450
GeneOntologyCellularComponentaxon

GARS1 DOCK7 SLC17A8 ADGRL1 SLC2A13 MAP2K1 ADGRL3 ATL1 SLC17A6

5.57e-04891569GO:0030424
DomainMFS_dom

SLC37A1 SLC16A1 SLC17A8 SLC2A13 MFSD4B SLC17A6

2.65e-06134556IPR020846
DomainMFS

SLC37A1 SLC16A1 SLC17A8 MFSD4B SLC17A6

3.09e-0677555IPR011701
DomainMFS_1

SLC37A1 SLC16A1 SLC17A8 MFSD4B SLC17A6

3.09e-0677555PF07690
DomainAA/rel_permease1

SLC7A13 SLC7A6 SLC7A10

6.77e-0613553IPR002293
DomainAA_permease_2

SLC7A13 SLC7A6 SLC7A10

6.77e-0613553PF13520
DomainMFS

SLC37A1 SLC16A1 SLC17A8 SLC2A13 SLC17A6

1.63e-05108555PS50850
DomainLatrophilin

ADGRL1 ADGRL3

2.55e-053552PF02354
DomainGPCR_2_latrophilin_rcpt_C

ADGRL1 ADGRL3

2.55e-053552IPR003334
DomainAA-permease/SLC12A_dom

SLC7A13 SLC7A6 SLC7A10

3.58e-0522553IPR004841
DomainAA_permease

SLC7A13 SLC7A6 SLC7A10

3.58e-0522553PF00324
DomainMeTrfase

METTL2A METTL2B

5.09e-054552IPR026113
DomainLectin_gal-bd_dom

ADGRL1 ADGRL3

8.47e-055552IPR000922
DomainGal_Lectin

ADGRL1 ADGRL3

8.47e-055552PF02140
DomainSUEL_LECTIN

ADGRL1 ADGRL3

8.47e-055552PS50228
DomainGPCR_2_latrophilin

ADGRL1 ADGRL3

8.47e-055552IPR003924
DomainDUF3398

DOCK7 DOCK6

1.27e-046552PF11878
DomainMethyltransf_12

METTL2A METTL2B

1.27e-046552PF08242
DomainDOCK_C/D_N

DOCK7 DOCK6

1.27e-046552IPR021816
DomainMethyltransf_12

METTL2A METTL2B

1.27e-046552IPR013217
DomainDOCK_C

DOCK7 DOCK6

4.60e-0411552IPR010703
DomainDHR-1_domain

DOCK7 DOCK6

4.60e-0411552IPR027007
DomainDHR_2

DOCK7 DOCK6

4.60e-0411552PS51651
DomainDHR_1

DOCK7 DOCK6

4.60e-0411552PS51650
DomainDOCK-C2

DOCK7 DOCK6

4.60e-0411552PF14429
DomainDHR-2

DOCK7 DOCK6

4.60e-0411552IPR027357
DomainDHR-2

DOCK7 DOCK6

4.60e-0411552PF06920
DomainGAIN_dom_N

ADGRL1 ADGRL3

4.60e-0411552IPR032471
DomainGAIN

ADGRL1 ADGRL3

4.60e-0411552PF16489
DomainDOCK

DOCK7 DOCK6

4.60e-0411552IPR026791
DomainOlfac-like_dom

ADGRL1 ADGRL3

6.50e-0413552IPR003112
DomainOLF

ADGRL1 ADGRL3

6.50e-0413552SM00284
DomainOLF

ADGRL1 ADGRL3

6.50e-0413552PF02191
DomainOLF

ADGRL1 ADGRL3

6.50e-0413552PS51132
DomainMORN

ANKMY1 SETD7

8.72e-0415552PF02493
DomainMORN

ANKMY1 SETD7

8.72e-0415552IPR003409
DomainCONNEXINS_1

GJA3 GJA8

1.41e-0319552PS00407
DomainConnexin_N

GJA3 GJA8

1.56e-0320552IPR013092
DomainCONNEXINS_2

GJA3 GJA8

1.56e-0320552PS00408
DomainConnexin

GJA3 GJA8

1.56e-0320552PF00029
DomainConnexin_CCC

GJA3 GJA8

1.56e-0320552SM01089
DomainConnexin_CS

GJA3 GJA8

1.56e-0320552IPR017990
DomainConnexin

GJA3 GJA8

1.56e-0320552IPR000500
DomainConnexin_CCC

GJA3 GJA8

1.56e-0320552IPR019570
DomainCNX

GJA3 GJA8

1.56e-0320552SM00037
DomainABC_membrane

ABCB5 ABCB1

2.25e-0324552PF00664
DomainHormR

ADGRL1 ADGRL3

2.45e-0325552SM00008
DomainABC_TM1F

ABCB5 ABCB1

3.06e-0328552PS50929
DomainHRM

ADGRL1 ADGRL3

3.06e-0328552PF02793
DomainABC1_TM_dom

ABCB5 ABCB1

3.06e-0328552IPR011527
Domain-

ATP11C ATP1A2

3.99e-03325522.70.150.10
Domain-

ATP11C ATP1A2

3.99e-03325523.40.1110.10
DomainGPS

ADGRL1 ADGRL3

4.50e-0334552SM00303
DomainGPCR_2_secretin-like_CS

ADGRL1 ADGRL3

4.50e-0334552IPR017983
DomainGPS

ADGRL1 ADGRL3

4.76e-0335552PF01825
DomainATPase_P-typ_cyto_domN

ATP11C ATP1A2

4.76e-0335552IPR023299
DomainATPase_P-typ_P_site

ATP11C ATP1A2

5.03e-0336552IPR018303
DomainGPS

ADGRL1 ADGRL3

5.03e-0336552PS50221
DomainP_typ_ATPase

ATP11C ATP1A2

5.03e-0336552IPR001757
DomainATPASE_E1_E2

ATP11C ATP1A2

5.03e-0336552PS00154
DomainGPS

ADGRL1 ADGRL3

5.31e-0337552IPR000203
DomainATPase_P-typ_transduc_dom_A

ATP11C ATP1A2

5.31e-0337552IPR008250
DomainE1-E2_ATPase

ATP11C ATP1A2

5.31e-0337552PF00122
DomainG_PROTEIN_RECEP_F2_1

ADGRL1 ADGRL3

6.18e-0340552PS00649
DomainG_PROTEIN_RECEP_F2_3

ADGRL1 ADGRL3

6.18e-0340552PS50227
DomainGPCR_2_extracellular_dom

ADGRL1 ADGRL3

6.18e-0340552IPR001879
DomainABC_transporter_CS

ABCB5 ABCB1

6.80e-0342552IPR017871
DomainPSI

SLC2A13 PLXNA2

8.11e-0346552SM00423
DomainABC_TRANSPORTER_2

ABCB5 ABCB1

8.81e-0348552PS50893
DomainABC_tran

ABCB5 ABCB1

8.81e-0348552PF00005
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPV1 SLC16A1 ABCB5 SLC35B3 SLC17A8 ATP11C SLC2A13 ANO10 ATP1A2 SLC7A6 MFSD4B SLC7A10 AQP9 ABCB1 SLC17A6

2.82e-097364415M27287
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPV1 SLC16A1 ABCB5 SLC35B3 SLC17A8 ATP11C SLC2A13 ANO10 ATP1A2 SLC7A6 SLC7A10 AQP9 ABCB1 SLC17A6

9.85e-096814414MM14985
PathwayKEGG_MEDICUS_PATHOGEN_YERSINIA_YOPP_J_TO_TLR2_4_MAPK_SIGNALING_PATHWAY

MAP2K1 MAP2K2 MAP2K3

5.64e-076443M47636
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC16A1 SLC35B3 SLC17A8 SLC2A13 SLC7A6 MFSD4B SLC7A10 SLC17A6

8.66e-07249448M5988
PathwayREACTOME_UPTAKE_AND_FUNCTION_OF_ANTHRAX_TOXINS

MAP2K1 MAP2K2 MAP2K3

4.60e-0611443M27420
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC16A1 SLC35B3 SLC17A8 SLC2A13 SLC7A6 SLC7A10 SLC17A6

8.06e-06238447MM15076
PathwayBIOCARTA_HCMV_PATHWAY

MAP2K1 MAP2K2 MAP2K3

1.87e-0517443M8353
PathwayBIOCARTA_HCMV_PATHWAY

MAP2K1 MAP2K2 MAP2K3

1.87e-0517443MM1408
PathwayPID_ANTHRAX_PATHWAY

MAP2K1 MAP2K2 MAP2K3

2.24e-0518443M267
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

MAP2K1 ITGAV MAP2K2

2.65e-0519443MM15113
PathwayREACTOME_SIGNAL_TRANSDUCTION_BY_L1

MAP2K1 ITGAV MAP2K2

3.63e-0521443M878
PathwayWP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN

MAP2K1 MAP2K2 MAP2K3

3.63e-0521443M48342
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 SLC7A6 SLC7A10

5.49e-0524443MM17215
PathwayPID_VEGFR1_2_PATHWAY

MAP2K1 ITGAV MAP2K2 MAP2K3

6.16e-0569444M237
PathwayWP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION

MAP2K1 MAP2K2 MAP2K3

6.22e-0525443M39574
PathwayREACTOME_BASIGIN_INTERACTIONS

SLC16A1 SLC7A6 SLC7A10

6.22e-0525443M4974
PathwayKEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY

MAP2K1 MAP2K2 MAP2K3

7.02e-0526443M47565
PathwayBIOCARTA_PYK2_PATHWAY

MAP2K1 MAP2K2 MAP2K3

7.02e-0526443MM1431
PathwayBIOCARTA_PYK2_PATHWAY

MAP2K1 MAP2K2 MAP2K3

7.88e-0527443M7739
PathwayWP_FGFR3_SIGNALING_IN_CHONDROCYTE_PROLIFERATION_AND_TERMINAL_DIFFERENTIATION

NPR2 MAP2K1 MAP2K2

7.88e-0527443M39838
PathwayWP_MAPK_CASCADE

MAP2K1 MAP2K2 MAP2K3

8.80e-0528443MM15976
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_BRAF_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.46e-055442M49016
PathwayREACTOME_UPTAKE_AND_ACTIONS_OF_BACTERIAL_TOXINS

MAP2K1 MAP2K2 MAP2K3

9.80e-0529443M27431
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

1.42e-046442M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

MAP2K1 MAP2K2

1.42e-046442MM15273
PathwayWP_MAPK_CASCADE

MAP2K1 MAP2K2 MAP2K3

1.45e-0433443M39594
PathwayBIOCARTA_FMLP_PATHWAY

MAP2K1 MAP2K2 MAP2K3

1.59e-0434443M10287
PathwayPID_MAPK_TRK_PATHWAY

TRPV1 MAP2K1 MAP2K3

1.59e-0434443M270
PathwayBIOCARTA_FMLP_PATHWAY

MAP2K1 MAP2K2 MAP2K3

1.59e-0434443MM1399
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING

MAP2K1 MAP2K2 MAP2K3

1.89e-0436443M39908
PathwayWP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY

MAP2K1 MAP2K2 MAP2K3

2.05e-0437443M42558
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

MAP2K1 ITGAV MAP2K2 MAP2K3

2.81e-04102444M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

MAP2K1 ITGAV MAP2K2 MAP2K3

2.81e-04102444MM15830
PathwayPID_CXCR3_PATHWAY

MAP2K1 MAP2K2 MAP2K3

3.21e-0443443M222
PathwayWP_ETHANOL_METABOLISM_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

3.38e-049442M39481
PathwayPID_ERBB2_ERBB3_PATHWAY

DOCK7 MAP2K1 MAP2K2

3.44e-0444443M175
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC17A8 SLC7A6 SLC7A10 SLC17A6

3.49e-04108444M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC17A8 SLC7A6 SLC7A10 SLC17A6

3.62e-04109444MM15074
PathwayWP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS

MAP2K1 MAP2K2 MAP2K3

3.92e-0446443M39805
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

4.22e-0410442M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

4.22e-0410442M47420
PathwayWP_ETHANOL_METABOLISM_RESULTING_IN_PRODUCTION_OF_ROS_BY_CYP2E1

MAP2K1 MAP2K2

4.22e-0410442MM15821
PathwayKEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

4.22e-0410442M47735
PathwayWP_INTERLEUKIN1_IL1_STRUCTURAL_PATHWAY

MAP2K1 MAP2K2 MAP2K3

4.73e-0449443M39543
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

5.14e-0411442M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

5.14e-0411442M47371
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

SLC17A8 ATP1A2 SLC17A6

5.32e-0451443M39457
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

6.16e-0412442M47369
PathwayKEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

6.16e-0412442M47597
PathwayREACTOME_ORGANIC_ANION_TRANSPORTERS

SLC17A8 SLC17A6

6.16e-0412442M27350
PathwayREACTOME_ORGANIC_ANION_TRANSPORTERS

SLC17A8 SLC17A6

6.16e-0412442MM15087
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

6.16e-0412442M47815
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

MAP2K1 MAP2K2 PLXNA2

6.30e-0454443M42568
PathwayWP_IL1_SIGNALING

MAP2K1 MAP2K2 MAP2K3

6.65e-0455443M39346
PathwayWP_CARDIAC_HYPERTROPHIC_RESPONSE

MAP2K1 MAP2K2 MAP2K3

6.65e-0455443M39685
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

7.27e-0413442M47589
PathwayBIOCARTA_CDK5_PATHWAY

MAP2K1 MAP2K2

7.27e-0413442M89
PathwayWP_OSTEOPONTIN_SIGNALING

MAP2K1 ITGAV

7.27e-0413442M39603
PathwayBIOCARTA_BARR_MAPK_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M668
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47378
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47384
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

MAP2K1 MAP2K2

8.46e-0414442M622
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

MAP2K1 MAP2K2

8.46e-0414442MM14667
PathwayBIOCARTA_CDK5_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442MM1457
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442M47488
PathwayBIOCARTA_BARR_MAPK_PATHWAY

MAP2K1 MAP2K2

8.46e-0414442MM1489
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47375
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47382
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

9.74e-0415442M47531
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47801
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

MAP2K1 MAP2K2

1.11e-0316442M39882
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47483
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.11e-0316442M47682
PathwayREACTOME_L1CAM_INTERACTIONS

MAP2K1 ITGAV MAP2K2

1.23e-0368443MM14968
PathwayWP_ERK_PATHWAY_IN_HUNTINGTONS_DISEASE

MAP2K1 MAP2K2

1.26e-0317442M39564
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

MAP2K1 MAP2K2

1.26e-0317442M47376
PathwayBIOCARTA_BARRESTIN_SRC_PATHWAY

MAP2K1 MAP2K2

1.26e-0317442M111
PathwayWP_IL9_SIGNALING

MAP2K1 MAP2K2

1.26e-0317442M39644
Pubmed

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

MAP2K1 MAP2K2 MAP2K3

1.58e-0845638226933
Pubmed

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

MAP2K1 MAP2K2

2.55e-0625629563949
Pubmed

Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes.

GJA3 GJA8

2.55e-06256226017495
Pubmed

Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas.

MAP2K1 MAP2K2

2.55e-06256227956260
Pubmed

Defining a link between gap junction communication, proteolysis, and cataract formation.

GJA3 GJA8

2.55e-06256211395508
Pubmed

Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.

MAP2K1 MAP2K2

2.55e-06256217981815
Pubmed

Latrophilin receptors: novel bronchodilator targets in asthma.

ADGRL1 ADGRL3

2.55e-06256227325752
Pubmed

Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation.

GJA3 GJA8

2.55e-06256216687738
Pubmed

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

MAP2K1 MAP2K2

2.55e-06256228746311
Pubmed

Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2.

GJA3 GJA8

2.55e-06256223300808
Pubmed

Mek2 is dispensable for mouse growth and development.

MAP2K1 MAP2K2

2.55e-06256212832465
Pubmed

Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance.

GJA3 GJA8

2.55e-06256234226295
Pubmed

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.

MAP2K1 MAP2K2

2.55e-06256230087384
Pubmed

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.

MAP2K1 MAP2K2

2.55e-06256219014680
Pubmed

Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.

MAP2K1 MAP2K2

2.55e-06256222833572
Pubmed

Calcium-Activated Chloride Channels in Newly Differentiating Mouse Lens Fiber Cells and Their Role in Volume Regulation.

GJA3 GJA8

2.55e-06256230995319
Pubmed

Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cells.

GJA3 GJA8

2.55e-06256224380846
Pubmed

ERK1/2 can feedback-regulate cellular MEK1/2 levels.

MAP2K1 MAP2K2

2.55e-06256226163823
Pubmed

Dominant cataracts result from incongruous mixing of wild-type lens connexins.

GJA3 GJA8

2.55e-06256212782682
Pubmed

Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism.

MAP2K1 MAP2K2

2.55e-06256236189831
Pubmed

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.

MAP2K1 MAP2K2

2.55e-06256222805292
Pubmed

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.

MAP2K1 MAP2K2

2.55e-06256222805291
Pubmed

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells.

MAP2K1 MAP2K2

2.55e-06256226625317
Pubmed

The clinical relevance and prognostic significance of adenosine triphosphate ATP-binding cassette (ABCB5) and multidrug resistance (MDR1) genes expression in acute leukemia: an Egyptian study.

ABCB5 ABCB1

2.55e-06256224804815
Pubmed

Functional effects of Cx50 mutations associated with congenital cataracts.

GJA3 GJA8

2.55e-06256224005045
Pubmed

Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.

MAP2K1 MAP2K2

2.55e-06256235975983
Pubmed

Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc.

MAP2K1 MAP2K2

2.55e-06256216162927
Pubmed

Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmic dynein/dynactin-mediated poleward transport and cyclin B degradation-dependent release from spindle poles.

MAP2K1 MAP2K2

2.55e-06256217507801
Pubmed

Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice.

GJA3 GJA8

2.55e-06256236139360
Pubmed

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens.

GJA8 TRPV1

2.55e-06256232598448
Pubmed

Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury.

CCR2 SLC17A6

2.55e-06256236807640
Pubmed

Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.

MAP2K1 MAP2K2

2.55e-0625628529659
Pubmed

Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.

MAP2K1 MAP2K2

2.55e-06256221699731
Pubmed

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

MAP2K1 MAP2K2

2.55e-06256217419998
Pubmed

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

MAP2K1 MAP2K2

2.55e-0625621381507
Pubmed

Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?

GJA3 GJA8

2.55e-06256233036381
Pubmed

[Mek1 and Mek2 functions in the formation of the blood placental barrier].

MAP2K1 MAP2K2

2.55e-06256222549869
Pubmed

The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.

MAP2K1 MAP2K2

2.55e-06256223480967
Pubmed

A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice.

GJA3 GJA8

2.55e-06256211875045
Pubmed

Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1/2.

MAP2K1 MAP2K2

2.55e-06256223237773
Pubmed

Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells.

GJA3 GJA8

2.55e-06256216696970
Pubmed

MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response.

MAP2K1 MAP2K2

2.55e-06256223735655
Pubmed

Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain.

SLC7A10 ABCB1

2.55e-06256226796213
Pubmed

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.

MAP2K1 MAP2K2

2.55e-06256235069558
Pubmed

Connexin46fs380 causes progressive cataracts.

GJA3 GJA8

2.55e-06256225103261
Pubmed

Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization.

GJA3 GJA8

2.55e-06256227281269
Pubmed

Cisplatin inhibits MEK1/2.

MAP2K1 MAP2K2

2.55e-06256226155939
Pubmed

Connexin 50-R205G Mutation Perturbs Lens Epithelial Cell Proliferation and Differentiation.

GJA3 GJA8

2.55e-06256232182330
Pubmed

Connections between connexins, calcium, and cataracts in the lens.

GJA3 GJA8

2.55e-06256215452195
Pubmed

Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin.

MAP2K1 MAP2K2

2.55e-06256219198628
Pubmed

Gap junction communication influences intercellular protein distribution in the lens.

GJA3 GJA8

2.55e-06256218462719
Pubmed

Structure of native lens connexin 46/50 intercellular channels by cryo-EM.

GJA3 GJA8

2.55e-06256230542154
Pubmed

Gap junctional coupling in lenses lacking alpha3 connexin.

GJA3 GJA8

2.55e-0625629860964
Pubmed

Properties of connexin 46 hemichannels in dissociated lens fiber cells.

GJA3 GJA8

2.55e-06256220861491
Pubmed

The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.

MAP2K1 MAP2K2

2.55e-06256221527500
Pubmed

Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.

MAP2K1 MAP2K2

2.55e-06256215979847
Pubmed

ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro.

MAP2K1 MAP2K2

2.55e-06256225491074
Pubmed

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

MAP2K1 MAP2K2

2.55e-06256219383924
Pubmed

Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2.

MAP2K1 MAP2K2

2.55e-06256220172001
Pubmed

Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32.

MAP2K1 MAP2K2

2.55e-06256210828601
Pubmed

MEK1 and MEK2, different regulators of the G1/S transition.

MAP2K1 MAP2K2

2.55e-06256215284233
Pubmed

Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis.

GJA8 MAP2K1

2.55e-06256219321662
Pubmed

Unique and redundant connexin contributions to lens development.

GJA3 GJA8

2.55e-06256211786642
Pubmed

Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations.

MAP2K1 MAP2K2

2.55e-06256219156172
Pubmed

p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.

MAP2K1 MAP2K2

2.55e-06256212839928
Pubmed

Identification and preliminary functional analysis of two novel congenital cataract associated mutations of Cx46 and Cx50.

GJA3 GJA8

2.55e-06256231618082
Pubmed

Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse.

MAP2K1 MAP2K2

2.55e-06256222561024
Pubmed

Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.

SLC17A8 SLC17A6

2.55e-06256228559797
Pubmed

MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.

MAP2K1 MAP2K2

2.55e-06256216957420
Pubmed

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

MAP2K1 MAP2K2

2.55e-06256215543157
Pubmed

Mutation analysis in Chinese families with autosomal dominant hereditary cataracts.

GJA3 GJA8

2.55e-06256225549162
Pubmed

Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice.

GJA3 GJA8

2.55e-06256216740340
Pubmed

T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate.

MAP2K1 MAP2K2

2.55e-06256219144315
Pubmed

Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.

MAP2K1 MAP2K2

2.55e-06256219500021
Pubmed

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

MAP2K1 MAP2K2

2.55e-06256222197931
Pubmed

Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.

ADGRL1 ABCB1

2.55e-06256229938681
Pubmed

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.

MAP2K1 MAP2K2

2.55e-06256218390968
Pubmed

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.

MAP2K1 MAP2K2

7.63e-06356210489373
Pubmed

Charged multivesicular body protein 4b forms complexes with gap junction proteins during lens fiber cell differentiation.

GJA3 GJA8

7.63e-06356236880430
Pubmed

A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.

ADGRL1 ADGRL3

7.63e-06356210994649
Pubmed

Is diagnosing cardio-facio-cutaneous (CFC) syndrome still a challenge? Delineation of the phenotype in 15 Polish patients with proven mutations, including novel mutations in the BRAF1 gene.

MAP2K1 MAP2K2

7.63e-06356225463315
Pubmed

The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.

ADGRL1 ADGRL3

7.63e-06356215066411
Pubmed

Median raphe controls acquisition of negative experience in the mouse.

SLC17A8 SLC17A6

7.63e-06356231780530
Pubmed

Homeostatic regulation of excitatory synapses on striatal medium spiny neurons expressing the D2 dopamine receptor.

SLC17A8 SLC17A6

7.63e-06356225782435
Pubmed

Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.

MAP2K1 MAP2K2

7.63e-06356225600339
Pubmed

Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.

MAP2K1 MAP2K2

7.63e-06356218060073
Pubmed

Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.

SLC17A8 SLC17A6

7.63e-06356223467360
Pubmed

Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen.

MAP2K1 ITGAV

7.63e-06356215557124
Pubmed

Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.

MAP2K1 MAP2K2

7.63e-06356227913296
Pubmed

Glutamate in primary afferents is required for itch transmission.

TRPV1 SLC17A6

7.63e-06356234986325
Pubmed

Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor γ coactivator-1β expression.

MAP2K1 MAP2K2

7.63e-06356221458501
Pubmed

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome.

MAP2K1 MAP2K2

7.63e-06356222393900
Pubmed

VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents.

TRPV1 SLC17A6

7.63e-06356225615623
Pubmed

Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5.

MAP2K1 MAP2K3

7.63e-0635629465908
Pubmed

Role of the monocyte chemoattractant protein-1/C-C chemokine receptor 2 signaling pathway in transient receptor potential vanilloid type 1 ablation-induced renal injury in salt-sensitive hypertension.

CCR2 TRPV1

7.63e-06356225585624
Pubmed

Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis.

GJA3 GJA8

7.63e-06356216611690
Pubmed

p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia.

MAP2K1 MAP2K2

7.63e-06356214672918
Pubmed

Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients.

ABCB5 ABCB1

7.63e-0635629542318
Pubmed

A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC)†.

MAP2K1 MAP2K2

7.63e-06356225722381
Pubmed

Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT.

MAP2K1 MAP2K3

7.63e-06356210997882
InteractionTTYH1 interactions

CNNM1 LPCAT3 COA1 ADGRL1 ATP11C MANEA ANO10 ABCB1

1.68e-06300568int:TTYH1
InteractionNKAIN1 interactions

CNNM1 ADGRL1 ATP11C NKAIN1

3.19e-0565564int:NKAIN1
GeneFamilySolute carriers

SLC37A1 SLC7A13 SLC16A1 SLC35B3 SLC17A8 SLC2A13 SLC7A6 SLC7A10 SLC17A6

3.73e-07395449752
GeneFamilyMitogen-activated protein kinase kinases

MAP2K1 MAP2K2 MAP2K3

4.67e-077443653
GeneFamilyAdhesion G protein-coupled receptors, subfamily L

ADGRL1 ADGRL3

3.46e-054442918
GeneFamilyATP binding cassette subfamily B

ABCB5 ABCB1

3.14e-0411442806
GeneFamilyGap junction proteins

GJA3 GJA8

1.30e-0322442314
GeneFamilyMethyltransferase like

METTL2A METTL2B

2.91e-0333442963
DrugAC1L3V8L

MAP2K1 MAP2K2 MAP2K3

2.80e-076563CID000122778
DrugHeptachlor

SLC16A1 SLC7A6 MAP2K1 MAP2K2 AQP9 ABCB1

3.12e-07111566ctd:D006533
DrugHWY-289

MAP2K1 MAP2K2 MAP2K3

7.82e-078563CID000487138
Drugmefloquina

GJA3 GJA8 ABCB5 ABCB1

9.83e-0731564CID000004046
DrugAC1L1F8K

NPR2 ABCB5 MAP2K3 ABCB1

1.12e-0632564CID000003130
DrugZidovudine

SLC37A1 SLC16A1 SLC35B3 GARS1 SLC17A8 TRIM22 SLC7A10 AQP9 ABCB1

4.68e-06521569ctd:D015215
DrugTAK 733

MAP2K1 MAP2K2

5.94e-062562ctd:C558666
Drug8-(3,3-dimethylallyl)chrysin

ABCB5 ABCB1

5.94e-062562CID005281903
Drugmesochlorin e6 monoethylenediamine

ABCB5 ABCB1

5.94e-062562CID005488855
DrugAC1L8LCS

ABCB5 ABCB1

5.94e-062562CID000383419
Drugsulfurmycin A

ABCB5 ABCB1

5.94e-062562CID000155836
DrugDAPDOX

ABCB5 ABCB1

5.94e-062562CID000164413
DrugAC1Q6JJG

ABCB5 ABCB1

5.94e-062562CID000164322
DrugYM212

ABCB5 ABCB1

5.94e-062562CID000129980
Drugtaxuspine C

ABCB5 ABCB1

5.94e-062562CID005321745
DrugRo11-2933

ABCB5 ABCB1

5.94e-062562CID000115215
Drugcnidiadin

ABCB5 ABCB1

5.94e-062562CID005315980
Drugconferone

ABCB5 ABCB1

5.94e-062562CID001757335
Drug2,2-diphenyl-1,3-dioxolane

ABCB5 ABCB1

5.94e-062562CID000283230
DrugVX-710-3

ABCB5 ABCB1

5.94e-062562CID006450549
DrugN-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

MAP2K1 MAP2K2

5.94e-062562ctd:C544830
DrugRo44-5912

ABCB5 ABCB1

5.94e-062562CID000197370
DrugNAc-LLY-amide

ABCB5 ABCB1

5.94e-062562CID000443109
Drug62820-12-6

ABCB5 ABCB1

5.94e-062562CID006449905
DrugMeprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; PC3; HT_HG-U133A

NPR2 P3H1 LPCAT3 ANKMY1 DOCK6 PLXNA2

8.56e-061965665723_DN
DrugFPT inhibitor II

MAP2K1 MAP2K2 MAP2K3

9.35e-0617563CID000001943
DrugAC1L323L

MAP2K1 MAP2K2 MAP2K3

1.12e-0518563CID000133056
DrugNIH-3

MAP2K1 MAP2K2 MAP2K3

1.33e-0519563CID009822007
DrugAC1MHEDP

GJA3 GJA8 ABCB5 ABCB1

1.54e-0561564CID003002894
Drug1y2g

ABCB5 ADGRL1 MAP2K1 MAP2K2 ABCB1

1.64e-05129565CID005287936
Drug2-chloroquinazoline

ABCB5 ABCB1

1.78e-053562CID000074054
Drugdendroamide A

ABCB5 ABCB1

1.78e-053562CID000177307
Drugfluoroanilinoazatoxin

ABCB5 ABCB1

1.78e-053562CID000378896
DrugRO5126766

MAP2K1 MAP2K2

1.78e-053562ctd:C577924
DrugDihydrocyclosporin C

ABCB5 ABCB1

1.78e-053562CID000196411
DrugNSC82591

ABCB5 ABCB1

1.78e-053562CID000579054
DrugCID5317124

ABCB5 ABCB1

1.78e-053562CID005317124
DrugNSC688503

ABCB5 ABCB1

1.78e-053562CID000390744
DrugWp159

ABCB5 ABCB1

1.78e-053562CID003060549
DrugCp-100356

ABCB5 ABCB1

1.78e-053562CID000196918
DrugBIBW22BS

ABCB5 ABCB1

1.78e-053562CID000132088
DrugAC1L2Z11

ABCB5 ABCB1

1.78e-053562CID000080228
DrugAC1NSGRQ

ABCB5 ABCB1

1.78e-053562CID005333904
DrugNK-250

ABCB5 ABCB1

1.78e-053562CID000164220
Drug5-N-acetylardeemin

ABCB5 ABCB1

1.78e-053562CID000127303
Drug1-bromo-4-chlorobutane

ABCB5 ABCB1

1.78e-053562CID000081364
Drugtaxinine

ABCB5 ABCB1

1.78e-053562CID005321702
DrugHapalosin

ABCB5 ABCB1

1.78e-053562CID000133055
DrugD-Val-Thz

ABCB5 ABCB1

1.78e-053562CID003082826
Drughaemanthidine

ABCB5 ABCB1

1.78e-053562CID000124066
Drugtaccalonolide A

ABCB5 ABCB1

1.78e-053562CID000441685
Drugtaccalonolide E

ABCB5 ABCB1

1.78e-053562CID005321583
Drugiodomycin

ABCB5 ABCB1

1.78e-053562CID000149155
DrugR101933

ABCB5 ABCB1

1.78e-053562CID000219080
DrugAC1L87CG

ABCB5 ABCB1

1.78e-053562CID000373763
Drugmethylazatoxin

ABCB5 ABCB1

1.78e-053562CID000148162
DrugTPGS

ABCB5 SETD7 ABCB1

1.82e-0521563CID000071406
DrugChebi:3796

MAP2K1 MAP2K2 MAP2K3

1.82e-0521563CID006857420
DrugNs102

MAP2K1 MAP2K2 MAP2K3

3.12e-0525563CID005311098
Druggeldanamycin

TRPV1 SLC16A1 ATP11C SLC2A13 MAP2K1 MAP2K2 PLXNA2

3.36e-05371567ctd:C001277
DrugAC1L3NEP

SLC7A13 SLC7A6 SLC7A10

3.52e-0526563CID000092096
DrugBIBX1382BS

MAP2K1 MAP2K2 MAP2K3

3.52e-0526563CID006918508
DrugGsh-pga1

ABCB5 ABCB1

3.55e-054562CID005281911
Drug9-methylphenazine-1-carboxylic acid

ABCB5 ABCB1

3.55e-054562CID004037810
Drugeupatin

ABCB5 ABCB1

3.55e-054562CID005317287
Drugtaxinine K

ABCB5 ABCB1

3.55e-054562CID005321708
DrugAHC-52

ABCB5 ABCB1

3.55e-054562CID000164115
DrugNK-252

ABCB5 ABCB1

3.55e-054562CID000130889
DrugMS-073

ABCB5 ABCB1

3.55e-054562CID000131119
DrugAC1L9UH6

ABCB5 ABCB1

3.55e-054562CID000456215
Drugteludipine

ABCB5 ABCB1

3.55e-054562CID006436165
Drugphellamurin

ABCB5 ABCB1

3.55e-054562CID000193876
DrugS 9788

ABCB5 ABCB1

3.55e-054562CID000107903
DrugBBR 2378

ABCB5 ABCB1

3.55e-054562CID000219053
Drugerysolin

ABCB5 ABCB1

3.55e-054562CID003080557
DrugCelecoxib

CCR2 P3H1 LPCAT3 SETD7 MAP2K1 MAP2K2 ABCB1

3.66e-05376567ctd:D000068579
Drugtariquidar

ABCB5 ITGAV ABCB1

3.95e-0527563CID000148201
Druganandamide

TRPV1 MAP2K1 MAP2K2

4.42e-0528563ctd:C078814
Drugtucaresol

MAP2K1 MAP2K2 MAP2K3

4.42e-0528563CID000055223
DrugCsh Cyclosporin

ABCB5 MAP2K1 ABCB1

4.42e-0528563CID006436249
DrugTexas Red

ABCB5 ADGRL1 ABCB1

4.42e-0528563CID000452705
Drug9-aminocamptothecin

ABCB5 ADGRL1 ABCB1

4.92e-0529563CID000072402
Drug2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

CCR2 TRPV1 MAP2K1 ITGAV MAP2K3 AQP9 ABCB1

5.42e-05400567ctd:C085911
Drugacetylvalerenolic acid

ABCB5 ABCB1

5.91e-055562CID006439585
Drugthiodicarb

ABCB5 ABCB1

5.91e-055562CID000062155
DrugSdz 280 446

ABCB5 ABCB1

5.91e-055562CID000164287
DrugN-methylhomoveratrylamine

ABCB5 ABCB1

5.91e-055562CID000077039
DrugAC1NSZ76

ABCB5 ABCB1

5.91e-055562CID005320215
DrugSDB-ethylenediamine

ABCB5 ABCB1

5.91e-055562CID006438957
DrugIaci

ABCB5 ABCB1

5.91e-055562CID000656579
DrugN-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime

MAP2K1 MAP2K2

5.91e-055562ctd:C068836
DrugCyclosporin C

ABCB5 ABCB1

5.91e-055562CID005287817
DrugAC1L2MCS

ABCB5 ABCB1

5.91e-055562CID000023441
Drugsarcolysin

SLC7A13 ABCB5 SLC7A6 SLC7A10 ABCB1

6.49e-05172565CID000004053
DrugK00039

MAP2K1 MAP2K2 MAP2K3

6.65e-0532563CID009549277
Drugalfentanil

ABCB5 ADGRL1 ABCB1

6.65e-0532563CID000051263
DrugAC1L1DBR

MAP2K1 MAP2K2 MAP2K3

7.30e-0533563CID000002279
DrugAC1MJ1SO

SLC16A1 ABCB5 ABCB1

7.30e-0533563CID003084042
Drugglyceryl 2-arachidonate

TRPV1 MAP2K1 MAP2K2

8.72e-0535563ctd:C094503
Drugtyrphostin A1

MAP2K1 MAP2K2 MAP2K3

8.72e-0535563CID000002063
Diseasesmall intestine adenocarcinoma (is_implicated_in)

MAP2K1 MAP2K2

1.06e-053562DOID:4906 (is_implicated_in)
Diseasecataract (implicated_via_orthology)

GJA3 GJA8 MAP2K1

5.21e-0538563DOID:83 (implicated_via_orthology)
DiseaseRASopathy (implicated_via_orthology)

MAP2K1 MAP2K2

1.26e-049562DOID:0080690 (implicated_via_orthology)
DiseaseCATARACT, COPPOCK-LIKE

GJA3 GJA8

1.26e-049562C1852438
DiseaseCataract, Pulverulent

GJA3 GJA8

1.26e-049562C1833118
Diseasecystic fibrosis (implicated_via_orthology)

ABCB5 ABCB1

1.26e-049562DOID:1485 (implicated_via_orthology)
DiseaseTurner Syndrome, Male

MAP2K1 MAP2K2

1.92e-0411562C0041409
DiseaseFemale Pseudo-Turner Syndrome

MAP2K1 MAP2K2

1.92e-0411562C1527404
DiseaseNoonan Syndrome 1

MAP2K1 MAP2K2

1.92e-0411562C4551602
Diseaselevel of Phosphatidylinositol (18:1_18:1) in blood serum

DOCK7 DOCK6

2.72e-0413562OBA_2045159
DiseaseNuclear cataract

GJA3 GJA8

5.31e-0418562C0392557
Diseaselevel of Phosphatidylinositol (18:0_18:1) in blood serum

DOCK7 DOCK6

5.31e-0418562OBA_2045155
DiseaseNuclear non-senile cataract

GJA3 GJA8

5.31e-0418562C1112705
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

MAP2K1 MAP2K2

5.93e-0419562C3501846
DiseaseCostello syndrome (disorder)

MAP2K1 MAP2K2

5.93e-0419562C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

MAP2K1 MAP2K2

5.93e-0419562C1843181
DiseaseCardio-facio-cutaneous syndrome

MAP2K1 MAP2K2

5.93e-0419562C1275081
Diseaselevel of Phosphatidylinositol (18:0_18:2) in blood serum

DOCK7 DOCK6

7.26e-0421562OBA_2045156
DiseaseLEOPARD Syndrome

MAP2K1 MAP2K2

7.98e-0422562C0175704
Diseaselevel of Phosphatidylinositol (18:0_20:4) in blood serum

DOCK7 DOCK6

8.72e-0423562OBA_2045158
DiseaseNoonan Syndrome

MAP2K1 MAP2K2

9.51e-0424562C0028326
Diseasemelanoma

CNNM1 ABCB5 MAP2K1 MAP2K2

1.27e-03248564C0025202
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

ADGRL1 ADGRL3

1.30e-0328562DOID:1094 (implicated_via_orthology)
Diseasecholesterol to total lipids in very large HDL percentage

DOCK7 DOCK6

1.59e-0331562EFO_0022243
Diseasepursuit maintenance gain measurement

SLC35B3 ANKMY1 PLXNA2

1.67e-03123563EFO_0008433
DiseaseMalignant Neoplasms

TRPV1 MAP2K1 ABCB1

1.87e-03128563C0006826
Diseaseesterified cholesterol measurement

DOCK7 DOCK6 NUP160

1.87e-03128563EFO_0008589

Protein segments in the cluster

PeptideGeneStartEntry
LGAFVGAATVFGIYY

AQP9

111

O43315
DYAYVTEIFGGLAGF

SLC7A10

106

Q9NS82
FNIGGRGFKAYYFSG

CDCP2

241

Q5VXM1
HAFIYFAYAAGFRFG

ABCB5

926

Q2M3G0
FAYAAGFRFGAYLIQ

ABCB5

931

Q2M3G0
VDGTGFVVYDGAVFY

ADGRL1

211

O94910
VDGTGFVVYDGALFF

ADGRL3

206

Q9HAR2
GVGIFSFARYGSDFY

AMZ2

196

Q86W34
TNGDYVFFYLDVFGE

NPR2

246

P20594
FLFEGYFGTILYTGD

DCLRE1B

106

Q9H816
IVGFYGAFYSDGEIS

MAP2K1

126

Q02750
VGFYGAFYSDGEISI

MAP2K2

131

P36507
LYLNGDFDGGNFYFT

P3H1

616

Q32P28
FSYAGCFRFGAYLVA

ABCB1

951

P08183
RGYFGETIALYFGFL

ANO10

201

Q9NW15
TTYVGFCVYAGFFGF

SLC16A1

351

P53985
YEEFGAFGGYGTLTS

MAGED4

36

Q96JG8
EFMFSYGNFGYGFSH

C2CD6

236

Q53TS8
VSHFDIFYIYGFASG

PLXNA2

236

O75051
IFYIYGFASGGFVYF

PLXNA2

241

O75051
FETGSYFFYLDGENV

MYF6

6

P23409
GNFYVRGDGTRVYFF

METTL2B

311

Q6P1Q9
EVAGFSYFYGAFLVG

LPCAT3

186

Q6P1A2
GFDGIYTYFATNGFT

MANEA

316

Q5SRI9
LFFFFYVGAEVTYGS

MFSD4B

236

Q5TF39
GNFYVRGDGTRVYFF

METTL2A

311

Q96IZ6
ASGAFTALFGLGYFY

SLC37A1

136

P57057
GGFFTYFVILAENGF

ATP1A2

861

P50993
FPYEFSYGADGGAKF

ATL1

221

Q8WXF7
RVFGTYFRVGFYGAH

DOCK6

1746

Q96HP0
YFRVGFYGAHFGDLD

DOCK6

1751

Q96HP0
TYFRVGFYGTKFGDL

DOCK7

1841

Q96N67
VADSEGDFYYGGAVF

GBGT1

251

Q8N5D6
FEVGFIVGHYFLYGF

GJA8

161

P48165
YSGPEGSYFGFAVDF

ITGAV

41

P06756
EAVGTAVDYGYFRFF

ANKMY1

776

Q9P2S6
FTGLYHIGYFGGIFF

CCR2

116

P41597
VGFIAGQYFLYGFEL

GJA3

161

Q9Y6H8
FHGVFYAGGFAIVYY

COA1

21

Q9GZY4
FYTVTFYGALFREGD

MAP2K3

121

P46734
TYYGAFFLYAGFAAV

SLC2A13

571

Q96QE2
FVDFAVYSGGVYLFT

TMEM161A

106

Q9NX61
RFFYDQAFAIYGGVS

GARS1

131

P41250
QAFAIYGGVSGLYDF

GARS1

136

P41250
FFFFDGSTLEGYYVD

SETD7

51

Q8WTS6
TYGYAFLFSLTGYFG

SLC35B3

296

Q9H1N7
IKFFTGDVFGYHGYT

SAE1

151

Q9UBE0
DSFDFIGGFDSYGYQ

NKAIN1

176

Q4KMZ8
ESAGGFYYVESGKLF

NUP160

81

Q12769
EGLRFENGAFTYYGV

CNNM1

686

Q9NRU3
AAFEGTVFFFGTYFL

ATP11C

966

Q8NB49
VHYGGVIFYAIFASG

SLC17A6

486

Q9P2U8
SVLGGVYFFFRGIQY

TRPV1

481

Q8NER1
FGYAALVTFGSIFGY

TMEM14A

6

Q9Y6G1
IFQGYFAYSGGACFT

SLC7A13

211

Q8TCU3
SYAYILEAFGGFIAF

SLC7A6

111

Q92536
AQTGFYGEFIIGEDY

ZNF496

241

Q96IT1
FTGLEFFTGVGYFRD

TMC5

486

Q6UXY8
AFGVFGCQYFSSGKY

TRIM22

341

Q8IYM9
HYSGVIFYGVFASGE

SLC17A8

491

Q8NDX2