Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium-dependent cysteine-type endopeptidase activity

CAPN9 CAPN3 CAPN15 CAPN10

5.24e-0817454GO:0004198
GeneOntologyMolecularFunctiontransporter activity

BEST3 SLC25A30 ATP13A5 SLC28A3 APOC4 RFT1 KCNC1 SLC4A5 SLCO2B1 ABCC6 SLC25A14 TMEM63A

1.95e-0512894512GO:0005215
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

BEST3 SLC25A30 SLC4A5 ABCC6 SLC25A14

4.02e-05171455GO:0015103
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

CAPN9 CAPN3 CAPN15 CAPN10

4.18e-0586454GO:0004197
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC25A30 SLC4A5 SLC25A14

5.07e-0532453GO:0005452
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC25A30 ATP13A5 SLC28A3 SLC4A5 SLCO2B1 ABCC6 SLC25A14

8.79e-05477457GO:0022804
GeneOntologyMolecularFunctiontransmembrane transporter activity

BEST3 SLC25A30 ATP13A5 SLC28A3 KCNC1 SLC4A5 SLCO2B1 ABCC6 SLC25A14 TMEM63A

2.39e-0411804510GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

BEST3 SLC25A30 SLC28A3 KCNC1 SLC4A5 ABCC6 SLC25A14 TMEM63A

2.58e-04758458GO:0015318
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC25A30 SLC28A3 SLC4A5 SLCO2B1 SLC25A14

5.20e-04296455GO:0015291
GeneOntologyMolecularFunctioncysteine-type peptidase activity

CAPN9 CAPN3 CAPN15 CAPN10

9.07e-04192454GO:0008234
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

BEST3 ATP13A5 SLC28A3 KCNC1 SLC4A5 SLC25A14 TMEM63A

1.84e-03793457GO:0015075
GeneOntologyMolecularFunctionendopeptidase activity

CAPN9 ADAM33 CAPN3 CAPN15 CAPN10

2.72e-03430455GO:0004175
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

ATP13A5 SLC28A3 KCNC1 SLC4A5 SLC25A14 TMEM63A

3.57e-03664456GO:0008324
GeneOntologyMolecularFunctionantiporter activity

SLC25A30 SLC4A5 SLC25A14

3.71e-03138453GO:0015297
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

BEST3 SLC4A5 SLC25A14

4.77e-03151453GO:0008509
GeneOntologyBiologicalProcessinorganic anion transport

BEST3 SLC25A30 SLC4A5 ABCC6 SLC25A14

3.52e-05180435GO:0015698
DomainCalpain_cysteine_protease

CAPN9 CAPN3 CAPN15 CAPN10

2.17e-0814424IPR022684
DomainCysPc

CAPN9 CAPN3 CAPN15 CAPN10

2.96e-0815424SM00230
DomainCALPAIN_CAT

CAPN9 CAPN3 CAPN15 CAPN10

2.96e-0815424PS50203
DomainPeptidase_C2_calpain_cat

CAPN9 CAPN3 CAPN15 CAPN10

2.96e-0815424IPR001300
DomainPeptidase_C2

CAPN9 CAPN3 CAPN15 CAPN10

2.96e-0815424PF00648
DomainTHIOL_PROTEASE_CYS

CAPN9 CAPN3 CAPN15 CAPN10

3.19e-0726424PS00139
DomainTHIOL_PROTEASE_ASN

CAPN9 CAPN3 CAPN15 CAPN10

3.73e-0727424PS00640
DomainTHIOL_PROTEASE_HIS

CAPN9 CAPN3 CAPN15 CAPN10

3.73e-0727424PS00639
DomainPept_cys_AS

CAPN9 CAPN3 CAPN15 CAPN10

4.35e-0728424IPR000169
DomainCalpain_III

CAPN9 CAPN3 CAPN10

2.29e-0612423IPR022683
Domaincalpain_III

CAPN9 CAPN3 CAPN10

2.29e-0612423SM00720
DomainC2_III

CAPN9 CAPN3 CAPN10

2.29e-0612423IPR033883
DomainCalpain_domain_III

CAPN9 CAPN3 CAPN10

2.98e-0613423IPR022682
DomainCalpain_III

CAPN9 CAPN3 CAPN10

2.98e-0613423PF01067
DomainMit_uncoupling

SLC25A30 SLC25A14

3.21e-0412422IPR002030
DomainEF-hand_8

CAPN9 CAPN3

2.65e-0334422PF13833
DomainSOLCAR

SLC25A30 SLC25A14

6.33e-0353422PS50920
DomainMito_carr

SLC25A30 SLC25A14

6.33e-0353422PF00153
Domain-

SLC25A30 SLC25A14

6.33e-03534221.50.40.10
DomainMt_carrier_dom

SLC25A30 SLC25A14

6.33e-0353422IPR023395
DomainMitochondrial_sb/sol_carrier

SLC25A30 SLC25A14

6.33e-0353422IPR018108
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

CAPN9 VAV3 CAPN3 CAPN10

1.01e-04102344M39577
PathwayWP_INTEGRINMEDIATED_CELL_ADHESION

CAPN9 VAV3 CAPN3 CAPN10

1.01e-04102344MM15830
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

CAPN9 CAPN3 CAPN15 CAPN10

1.56e-04114344MM14571
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

BEST3 ATP13A5 SLC28A3 LMF2 APOC4 SLC4A5 SLCO2B1 ABCC6

1.69e-04681348MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

BEST3 ATP13A5 SLC28A3 LMF2 APOC4 SLC4A5 SLCO2B1 ABCC6

2.87e-04736348M27287
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

CAPN9 CAPN3 CAPN15 CAPN10

3.43e-04140344M587
Pubmed

The human uncoupling proteins 5 and 6 (UCP5/SLC25A14 and UCP6/SLC25A30) transport sulfur oxyanions, phosphate and dicarboxylates.

SLC25A30 SLC25A14

1.79e-06247231356773
Pubmed

Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.

CAPN3 CAPN10

1.07e-05447212634108
Pubmed

Structure and physiological function of calpains.

CAPN3 CAPN10

3.74e-0574729396712
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

BSCL2 LMF2 MAN1A2 RFT1 TM9SF4 HYAL3 B3GALNT2 KIAA0319L

1.87e-04120147835696571
Pubmed

Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

SLCO2B1 ABCC6

2.12e-041647235307651
Pubmed

CPEB2-eEF2 interaction impedes HIF-1α RNA translation.

BSCL2 CAPN15

4.84e-042447222157746
Pubmed

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.

RAMAC OSBPL1A

4.84e-042447224710276
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PAQR5 BSCL2 YJEFN3 CENATAC SLC4A5 TM9SF4 B3GALNT2 TMEM63A

7.85e-04148947828611215
Pubmed

Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.

CAPN15 CAPN10

9.19e-043347236964131
GeneFamilyC2 domain containing|Calpains

CAPN9 CAPN3 CAPN15 CAPN10

9.52e-0915314975
GeneFamilySolute carriers

SLC25A30 SLC28A3 SLC4A5 SLCO2B1 SLC25A14

5.16e-04395315752
DrugMeclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

LMF2 CUL7 CAPN15 CAPN10 KIAA0319L TMEM63A

2.73e-061974665244_DN
DrugLoracarbef [121961-22-6]; Up 200; 10.8uM; HL60; HT_HG-U133A

SFI1 LMF2 CAPN15 CAPN10 TMEM63A

4.51e-051954652970_UP
DrugEpicatechin-(-) [154-23-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

SFI1 LMF2 CAPN15 KIAA0319L TMEM63A

4.62e-051964652815_UP
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CAPN9 LMF2 CAPN15 CAPN10 KIAA0319L

4.62e-051964655386_DN
DrugBaclofen (R,S) [1134-47-0]; Up 200; 18.8uM; HL60; HG-U133A

GHRHR APOC4 SLC4A5 SLCO2B1 TMEM63A

4.62e-051964652036_UP
DrugSulfisoxazole [127-69-5]; Down 200; 15uM; MCF7; HT_HG-U133A

LMF2 CUL7 CAPN10 KIAA0319L TMEM63A

4.62e-051964655257_DN
DrugLY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A

LMF2 CUL7 CAPN10 KIAA0319L TMEM63A

4.74e-051974655576_DN
DrugPempidine tartrate [546-48-5]; Down 200; 13uM; HL60; HT_HG-U133A

SFI1 MAN1A2 TM9SF4 CAPN15 CAPN10

4.74e-051974652172_DN
DrugEthynodiol diacetate [297-76-7]; Down 200; 10.4uM; MCF7; HT_HG-U133A

CAPN9 GHRHR LMF2 APOC4 CAPN10

4.85e-051984656479_DN
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; HL60; HT_HG-U133A

SFI1 SLCO2B1 CAPN3 KIAA0319L OSBPL1A

4.85e-051984653128_UP
Drugwortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A

SFI1 LMF2 SLC25A14 CAPN3 KIAA0319L

4.85e-051984656202_DN
DrugCefotetan [69712-56-7]; Down 200; 7uM; HL60; HT_HG-U133A

BSCL2 LMF2 TM9SF4 CAPN3 OSBPL1A

4.97e-051994651319_DN
Diseasehereditary spastic paraplegia (implicated_via_orthology)

CAPN9 ATP13A5 CAPN3

3.92e-0543453DOID:2476 (implicated_via_orthology)
DiseaseCFTR mutation carrier status

SLC28A3 VAV3

6.67e-0425452EFO_0021794
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CAPN9 CAPN3

1.39e-0336452DOID:11723 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
NRWWNQFVNLPWPDR

BEST3

91

Q8N1M1
DWIASQFSGRPSWWQ

ERVPABLB-1

436

P60509
GLLLVFYWRPQWRVW

ATP13A5

46

Q4VNC0
PAAWRVWNLNHLWGR

CCDC88B

86

A6NC98
AQWKLWRQRPGFAIW

C2orf27A

111

P0DPF5
WAQWKLWRQRPGFAI

CDRT15P3

116

P0DPF6
NATLWAFLQWRRGLW

ADAM33

276

Q9BZ11
IQNPWGRRCWQGLWR

CAPN10

261

Q9HC96
VVNRTRDGWQWFWSP

APOC4

61

P55056
RDGWQWFWSPSTFRG

APOC4

66

P55056
WGWPSDNRSNQWHGR

RAMAC

71

Q9BTL3
PLGVFWSLFLGWIWL

RFT1

91

Q96AA3
NIWTHLLPFWFFAWR

PAQR5

51

Q9NXK6
RNPWGRFSWNGSWSD

CAPN15

736

O75808
LLGLGWNWASWRQSP

KIAA0319L

151

Q8IZA0
WWQLGRLRQLHPWCS

C9orf131

56

Q5VYM1
VWAVLQLGWRPGWFL

PDCD1

11

Q15116
LQWTWLGWAELQFGN

CUL7

1446

Q14999
LRWWLQWLGINFTLF

TMEM63A

416

O94886
PLWKSSRFFGWRLFW

OSBPL1A

241

Q9BXW6
WNWIRQSPSRGLEWL

IGHV6-1

56

A0A0B4J1U7
WIGGNLRGWFLWKRF

PRG3

161

Q9Y2Y8
LYKGFWPNWLRLGPW

SLC25A30

261

Q5SVS4
WPNWLRLGPWNIIFF

SLC25A30

266

Q5SVS4
GGFWRRWQPRIWALF

KCNC1

166

P48547
DGPNFWWGNFRLNWA

B3GALNT2

376

Q8NCR0
WWGNFRLNWAVDRTG

B3GALNT2

381

Q8NCR0
WCPLWAGNWGRRRAY

HYAL3

131

O43820
PSSRRAFWWLVLAGW

GHRHR

236

Q02643
LWRFTHDPRYRQWGW

MAN1A2

541

O60476
WLPSFGRVWNNGRRW

CENATAC

296

Q86UT8
QWVWGGIWPRHRFSL

BSCL2

256

Q96G97
IRNPWGQVEWNGSWS

CAPN9

276

O14815
LRNPWGQVEWNGSWS

CAPN3

356

P20807
LPAAFHTWNRLWRWR

SFI1

486

A8K8P3
FSQPGEQGQWWRRQW

LMF2

566

Q9BU23
FWWVSGLVWRGYRRP

ABCC6

216

O95255
PGRRLLNSHWFWLKW

SLC28A3

161

Q9HAS3
GLPFGIQWFLILWIW

MRGPRX2

236

Q96LB1
GLEWLGRASPSWWIF

LINC00477

91

Q96M19
YKGFWPNWLRLGPWN

SLC25A14

296

O95258
IVWGAWFWGRRSCQQ

TMIGD2

166

Q96BF3
RWWWRNFLVSGGSAF

TM9SF4

566

Q92544
RWVGAWWLGFLIAAG

SLCO2B1

271

O94956
AWGRQSWLEQIWNAG

YJEFN3

51

A6XGL0
WLLFNNWTGGSWFSL

KRT10-AS1

106

Q8N816
DRGWFVAPFGKNPWW

SLC4A5

816

Q9BY07
WFLSPRWILQFRRWA

nan

71

Q6ZVQ6
YGPVQWLRLWTQWRR

TMEM187

96

Q14656
DWLFGGVRWGWNFRC

ZNF746

371

Q6NUN9
WSGLRFFQPWGQWLR

ZDHHC12

161

Q96GR4
WWRGEVNGRVGWFPS

VAV3

826

Q9UKW4
LWGSWSVLGPWNRFF

NAPEPLD

266

Q6IQ20