Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	DOCK2 DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B LLGL2 TBC1D3I TBC1D3G IQGAP3 TBC1D3K TBC1D3F	1.60e-09	279	143	15	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK2 DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D PLEKHG7 TBC1D3C TBC1D3B LLGL2 HERC1 TBC1D3I TBC1D3G IQGAP3 TBC1D3K RASGRP2 TBC1D3F	2.43e-08	507	143	18	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK2 DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D PLEKHG7 TBC1D3C TBC1D3B LLGL2 HERC1 TBC1D3I TBC1D3G IQGAP3 TBC1D3K RASGRP2 TBC1D3F	2.43e-08	507	143	18	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	DOCK2 DOCK3 TBC1D3E MAL TBC1D3 TBC1D3H TBC1D3L TBC1D3D DAXX TBC1D3C TBC1D3B TRIM23 NLRP3 LLGL2 TBC1D3I TBC1D3G IQGAP3 TBC1D3K TBC1D3F	2.36e-07	656	143	19	GO:0008047
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	HCN3 SLC6A3 SLC8A2 SLC8A1 SLC9C1 TRPM5 SCN1B SLC4A9	3.27e-05	171	143	8	GO:0015081
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	SLC8A2 SLC8A1	1.52e-04	3	143	2	GO:1905060
GeneOntologyMolecularFunction	molecular function activator activity	DOCK2 DOCK3 TBC1D3E MAL TBC1D3 TBC1D3H TBC1D3L TBC1D3D DAXX TBC1D3C TBC1D3B TRIM23 NLRP3 BLM SEMA3A LLGL2 TBC1D3I TBC1D3G IQGAP3 TBC1D3K TBC1D3F	1.87e-04	1233	143	21	GO:0140677
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC8A2 SLC8A1 SLC9C1 SLC4A9	2.51e-04	43	143	4	GO:0140828
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK2 DOCK3 TBC1D3E MAL TBC1D3 TBC1D3H TBC1D3L TBC1D3D PLEKHG7 DAXX TBC1D3C TBC1D3B TRIM23 NLRP3 LLGL2 HERC1 TBC1D3I TBC1D3G IQGAP3 TBC1D3K RASGRP2 TBC1D3F	4.76e-04	1418	143	22	GO:0030234
GeneOntologyMolecularFunction	beta-N-acetylhexosaminidase activity	HEXA HEXB	7.50e-04	6	143	2	GO:0004563
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	INPP5K MTM1 MTMR2	9.27e-04	27	143	3	GO:0034593
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKX PRKY	1.04e-03	7	143	2	GO:0004691
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	INPP5K MTM1 MTMR2	1.27e-03	30	143	3	GO:0052866
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	1.39e-03	8	143	2	GO:0140945
GeneOntologyMolecularFunction	trace-amine receptor activity	TAAR5 TAAR8	1.39e-03	8	143	2	GO:0001594
GeneOntologyMolecularFunction	ATP-dependent activity	RAD51C DHX36 IPO8 MYO6 MYO1H NLRP3 BLM DNAH12 CLPB ATF7IP DDX20 MORC3	1.57e-03	614	143	12	GO:0140657
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	2.06e-10	109	140	11	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K RASGRP2 TBC1D3F	1.10e-07	244	140	12	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K RASGRP2 TBC1D3F	3.15e-06	335	140	12	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B NLRP3 TBC1D3I TBC1D3G TBC1D3K RASGRP2 TBC1D3F	3.65e-05	499	140	13	GO:0051345
GeneOntologyBiologicalProcess	response to dsDNA	RIOK3 EPG5	4.57e-05	2	140	2	GO:1990784
GeneOntologyBiologicalProcess	cellular response to dsDNA	RIOK3 EPG5	4.57e-05	2	140	2	GO:1990786
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	HCN3 SLC6A3 SLC8A2 SLC8A1 SLC9C1 TRPM5 SCN1B SLC4A9	8.95e-05	208	140	8	GO:0035725
GeneOntologyCellularComponent	beta-N-acetylhexosaminidase complex	HEXA HEXB	4.45e-05	2	140	2	GO:1905379
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	2.24e-12	49	138	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	5.19e-12	53	138	10	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	7.69e-12	55	138	10	IPR000195
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	7.69e-12	55	138	10	PS50086
Domain	Glycohydro_20b2	HEXA HEXB	5.42e-05	2	138	2	PF14845
Domain	-	HEXA HEXB	5.42e-05	2	138	2	3.30.379.10
Domain	Beta_hexosaminidase_sua/sub	HEXA HEXB	5.42e-05	2	138	2	IPR025705
Domain	HEX_eukaryotic_N	HEXA HEXB	5.42e-05	2	138	2	IPR029019
Domain	Chitobiase/Hex_dom_2-like	HEXA HEXB	5.42e-05	2	138	2	IPR029018
Domain	Glyco_hydro_20_cat	HEXA HEXB	1.62e-04	3	138	2	IPR015883
Domain	Glyco_hydro_20	HEXA HEXB	1.62e-04	3	138	2	PF00728
Domain	Na_Ca_Ex	SLC8A2 SLC8A1	1.62e-04	3	138	2	IPR004836
Domain	Na_Ca_Ex_C-exten	SLC8A2 SLC8A1	1.62e-04	3	138	2	IPR032452
Domain	Na_Ca_ex_C	SLC8A2 SLC8A1	1.62e-04	3	138	2	PF16494
Domain	FYrich_C	KMT2C KMT2D	5.34e-04	5	138	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	5.34e-04	5	138	2	IPR003888
Domain	FYRC	KMT2C KMT2D	5.34e-04	5	138	2	SM00542
Domain	FYRN	KMT2C KMT2D	5.34e-04	5	138	2	SM00541
Domain	DOCK_N	DOCK2 DOCK3	5.34e-04	5	138	2	PF16172
Domain	DOCK_N	DOCK2 DOCK3	5.34e-04	5	138	2	IPR032376
Domain	FYRN	KMT2C KMT2D	5.34e-04	5	138	2	PF05964
Domain	FYRC	KMT2C KMT2D	5.34e-04	5	138	2	PF05965
Domain	FYRC	KMT2C KMT2D	5.34e-04	5	138	2	PS51543
Domain	FYRN	KMT2C KMT2D	5.34e-04	5	138	2	PS51542
Domain	TAAR_fam	TAAR5 TAAR8	1.11e-03	7	138	2	IPR009132
Domain	SWIM	ZSWIM5 ZSWIM4	1.11e-03	7	138	2	PF04434
Domain	Calx_beta	SLC8A2 SLC8A1	1.47e-03	8	138	2	SM00237
Domain	Calx_beta	SLC8A2 SLC8A1	1.89e-03	9	138	2	IPR003644
Domain	ZF_SWIM	ZSWIM5 ZSWIM4	1.89e-03	9	138	2	PS50966
Domain	NaCa_Exmemb	SLC8A2 SLC8A1	1.89e-03	9	138	2	IPR004837
Domain	Na_Ca_ex	SLC8A2 SLC8A1	1.89e-03	9	138	2	PF01699
Domain	Znf_SWIM	ZSWIM5 ZSWIM4	1.89e-03	9	138	2	IPR007527
Domain	Calx-beta	SLC8A2 SLC8A1	1.89e-03	9	138	2	PF03160
Domain	-	HEXA HEXB CHI3L1	2.17e-03	35	138	3	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	HEXA HEXB CHI3L1	2.76e-03	38	138	3	IPR013781
Domain	DHR-1_domain	DOCK2 DOCK3	2.85e-03	11	138	2	IPR027007
Domain	DHR_2	DOCK2 DOCK3	2.85e-03	11	138	2	PS51651
Domain	DHR_1	DOCK2 DOCK3	2.85e-03	11	138	2	PS51650
Domain	DHR-2	DOCK2 DOCK3	2.85e-03	11	138	2	PF06920
Domain	DOCK	DOCK2 DOCK3	2.85e-03	11	138	2	IPR026791
Domain	DOCK_C	DOCK2 DOCK3	2.85e-03	11	138	2	IPR010703
Domain	DOCK-C2	DOCK2 DOCK3	2.85e-03	11	138	2	PF14429
Domain	DHR-2	DOCK2 DOCK3	2.85e-03	11	138	2	IPR027357
Domain	G_SEPTIN_dom	SEPTIN8 SEPTIN10	4.01e-03	13	138	2	IPR030379
Domain	Septin	SEPTIN8 SEPTIN10	4.01e-03	13	138	2	PF00735
Domain	G_SEPTIN	SEPTIN8 SEPTIN10	4.01e-03	13	138	2	PS51719
Domain	PX	SNX17 SNX31 PLD2	4.19e-03	44	138	3	SM00312
Domain	Myotubularin-like_Pase_dom	MTM1 MTMR2	4.65e-03	14	138	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTM1 MTMR2	4.65e-03	14	138	2	PS51339
Domain	Myotubularin_fam	MTM1 MTMR2	4.65e-03	14	138	2	IPR030564
Domain	Myotub-related	MTM1 MTMR2	4.65e-03	14	138	2	PF06602
Domain	Septin	SEPTIN8 SEPTIN10	4.65e-03	14	138	2	IPR016491
Domain	PX	SNX17 SNX31 PLD2	5.67e-03	49	138	3	PF00787
Domain	PX	SNX17 SNX31 PLD2	6.00e-03	50	138	3	PS50195
Domain	GRAM	MTM1 MTMR2	6.08e-03	16	138	2	SM00568
Domain	Post-SET_dom	KMT2C KMT2D	6.08e-03	16	138	2	IPR003616
Domain	PostSET	KMT2C KMT2D	6.08e-03	16	138	2	SM00508
Domain	AT_hook	AHCTF1 KMT2C	6.08e-03	16	138	2	PF02178
Domain	POST_SET	KMT2C KMT2D	6.08e-03	16	138	2	PS50868
Domain	-	SNX17 SNX31 PLD2	6.34e-03	51	138	3	3.30.1520.10
Domain	Phox	SNX17 SNX31 PLD2	6.70e-03	52	138	3	IPR001683
Domain	Glycoside_hydrolase_SF	HEXA HEXB CHI3L1	7.06e-03	53	138	3	IPR017853
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E IKZF3 TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K	3.68e-09	99	107	10	M46448
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	3.83e-27	11	143	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D FAM187A TBC1D3B TBC1D3G TBC1D3F	8.04e-10	74	143	8	16625196
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	PTCH1 KMT2C KMT2D	6.81e-08	3	143	3	22183980
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	2.71e-07	4	143	3	12359748
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	2.71e-07	4	143	3	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	6.77e-07	5	143	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	6.77e-07	5	143	3	8471161
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	WASHC4 SNX17 RIOK3 DAXX ATG2A SEPTIN8 SRRT VPS52 PPP4C SMG7 CLPB PRKCI PLD2 SEPTIN10 CDC27 PRKX MED12	1.40e-06	1038	143	17	26673895
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	RARS1 MYO6 AHCTF1 NUP98 TMEM33 FANCA NAA25 VPS52 NRSN2 DDX20 ITM2C OTULINL RAB1A IMMT IQGAP3	8.46e-06	942	143	15	31073040
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX36 WASHC4 SNX17 ATG2A SIK3 ADGRA2 SEPTIN8 KMT2C SMG7 RAB1A ANKS1A	1.29e-05	529	143	11	14621295
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	1.68e-05	2	143	2	7633447
Pubmed	Activity of lysosomal exoglycosidases in human gliomas.	HEXA HEXB	1.68e-05	2	143	2	16710745
Pubmed	Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.	HEXA HEXB	1.68e-05	2	143	2	3013851
Pubmed	Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.	HEXA HEXB	1.68e-05	2	143	2	6458607
Pubmed	Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	1.68e-05	2	143	2	8789434
Pubmed	Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.	HEXA HEXB	1.68e-05	2	143	2	2965147
Pubmed	Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.	PTCH1 BLM	1.68e-05	2	143	2	19995795
Pubmed	The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis.	HEXA HEXB	1.68e-05	2	143	2	1825792
Pubmed	Plasma and peripheral leukocyte beta-N-acetylhexosaminidase isoenzymes and disease activity in rheumatoid arthritis.	HEXA HEXB	1.68e-05	2	143	2	12413610
Pubmed	A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.	HEXA HEXB	1.68e-05	2	143	2	9694901
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	1.68e-05	2	143	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	1.68e-05	2	143	2	15879576
Pubmed	GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.	HEXA HEXB	1.68e-05	2	143	2	22789865
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	1.68e-05	2	143	2	31924266
Pubmed	Biochemical consequences of mutations causing the GM2 gangliosidoses.	HEXA HEXB	1.68e-05	2	143	2	10571007
Pubmed	Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.	HEXA HEXB	1.68e-05	2	143	2	7550345
Pubmed	Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology.	HEXA HEXB	1.68e-05	2	143	2	19166507
Pubmed	Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum.	SLC8A2 SLC8A1	1.68e-05	2	143	2	27411318
Pubmed	Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea.	SLC8A2 SLC8A1	1.68e-05	2	143	2	27928109
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	1.68e-05	2	143	2	28967912
Pubmed	Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay-Sachs Disease and Sandhoff Disease Mouse Models.	HEXA HEXB	1.68e-05	2	143	2	34201771
Pubmed	Novel bicistronic lentiviral vectors correct β-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis.	HEXA HEXB	1.68e-05	2	143	2	31682993
Pubmed	Three novel mutations in Iranian patients with Tay-Sachs disease.	HEXA HEXB	1.68e-05	2	143	2	24518553
Pubmed	Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.	DAXX TYK2	1.68e-05	2	143	2	12391177
Pubmed	Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells.	HEXA HEXB	1.68e-05	2	143	2	21637923
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	1.68e-05	2	143	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	1.68e-05	2	143	2	9302280
Pubmed	Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases.	HEXA HEXB	1.68e-05	2	143	2	9302266
Pubmed	Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria.	SLC8A2 SLC8A1	1.68e-05	2	143	2	25498502
Pubmed	Knock-down of HEXA and HEXB genes correlate with the absence of the immunostimulatory function of HSC-derived dendritic cells.	HEXA HEXB	1.68e-05	2	143	2	21997228
Pubmed	Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.	HEXA HEXB	1.68e-05	2	143	2	8896570
Pubmed	Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.	HEXA HEXB	1.68e-05	2	143	2	6230359
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	1.68e-05	2	143	2	36601880
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	1.68e-05	2	143	2	28483418
Pubmed	Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.	HEXA HEXB	1.68e-05	2	143	2	8123671
Pubmed	Genetic expression of hexokinase and glucose phosphate isomerase in late-stage mouse preimplantation embryos: transcription activities in glucose/phosphate-containing HTF and glucose/phosphate-free P1 media.	HEXA HEXB	1.68e-05	2	143	2	9237263
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	1.68e-05	2	143	2	34156443
Pubmed	Different expression of beta-N-acetylhexosaminidase in mouse tissues.	HEXA HEXB	1.68e-05	2	143	2	8147878
Pubmed	Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.	SLC8A2 SLC8A1	1.68e-05	2	143	2	26787195
Pubmed	Identification of domains in human beta-hexosaminidase that determine substrate specificity.	HEXA HEXB	1.68e-05	2	143	2	8663217
Pubmed	Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).	AGBL5 GZMB	1.68e-05	2	143	2	20519502
Pubmed	Pediatric reference data on activity of urinary N-acetyl-β-D-hexosaminidase and its isoenzymes.	HEXA HEXB	1.68e-05	2	143	2	28846871
Pubmed	I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.	HEXA HEXB	1.68e-05	2	143	2	10591618
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	1.68e-05	2	143	2	27280393
Pubmed	Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.	HEXA HEXB	1.68e-05	2	143	2	9417048
Pubmed	Expression of the neuropathy-associated MTMR2 gene rescues MTM1-associated myopathy.	MTM1 MTMR2	1.68e-05	2	143	2	28934386
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	1.68e-05	2	143	2	36869380
Pubmed	Physiological substrates for human lysosomal beta -hexosaminidase S.	HEXA HEXB	1.68e-05	2	143	2	11707436
Pubmed	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.	HEXA HEXB	1.68e-05	2	143	2	8634145
Pubmed	Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.	HEXA HEXB	1.68e-05	2	143	2	8672428
Pubmed	Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression.	LLGL2 PRKCI	1.68e-05	2	143	2	24318287
Pubmed	[Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].	HEXA HEXB	1.68e-05	2	143	2	23370522
Pubmed	Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.	HEXA HEXB	1.68e-05	2	143	2	8673609
Pubmed	Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.	HEXA HEXB	1.68e-05	2	143	2	15953731
Pubmed	Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.	HEXA HEXB	1.68e-05	2	143	2	2971395
Pubmed	Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology.	HEXA HEXB	1.68e-05	2	143	2	9184660
Pubmed	Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.	DAXX MORC3	1.68e-05	2	143	2	34650047
Pubmed	Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin.	AGBL5 GZMB	1.68e-05	2	143	2	24022482
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	1.68e-05	2	143	2	25346535
Pubmed	Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.	HEXA HEXB	1.68e-05	2	143	2	16698036
Pubmed	Accumulated α-synuclein affects the progression of GM2 gangliosidoses.	HEXA HEXB	1.68e-05	2	143	2	27453479
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	1.68e-05	2	143	2	10729225
Pubmed	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.	HEXA HEXB	1.68e-05	2	143	2	7959736
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	DOCK2 DHX36 WASHC4 RARS1 ATG2A TRAPPC1 PPP4C PRKCI RAB1A MED12	1.98e-05	454	143	10	33226137
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	RARS1 ZNF462 KMT2C KMT2D	2.99e-05	43	143	4	33472061
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	HEXB CHI3L1 NLRP3 FANCA BLM GYS2 GZMB IQGAP3	4.89e-05	313	143	8	20800603
Pubmed	Glycosphingolipid degradation and animal models of GM2-gangliosidoses.	HEXA HEXB	5.02e-05	3	143	2	9728335
Pubmed	HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry.	NLRP3 P2RY2	5.02e-05	3	143	2	31553908
Pubmed	Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.	DHX36 BLM	5.02e-05	3	143	2	27407146
Pubmed	Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity.	SLC6A3 TRPM5	5.02e-05	3	143	2	32259476
Pubmed	Mammalian septins nomenclature.	SEPTIN8 SEPTIN10	5.02e-05	3	143	2	12475938
Pubmed	High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.	SLC8A2 SLC8A1	5.02e-05	3	143	2	21382638
Pubmed	Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes.	HEXA HEXB	5.02e-05	3	143	2	1054503
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	5.02e-05	3	143	2	21030649
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	5.02e-05	3	143	2	23932714
Pubmed	Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides.	HEXA HEXB	5.02e-05	3	143	2	9645704
Pubmed	Hyaluronidase 1 and β-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation.	HEXA HEXB	5.02e-05	3	143	2	22451654
Pubmed	The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.	SLC8A2 SLC8A1	5.02e-05	3	143	2	34127021
Pubmed	Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production.	NLRP3 P2RY2	5.02e-05	3	143	2	32630144
Pubmed	Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses.	CHI3L1 NLRP3	5.02e-05	3	143	2	22817986
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	5.02e-05	3	143	2	21683083
Pubmed	Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment.	HEXA HEXB	5.02e-05	3	143	2	9223328
Pubmed	Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.	SLC8A2 SLC8A1	5.02e-05	3	143	2	29594857
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	5.02e-05	3	143	2	17980165
Pubmed	A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal.	SEMA3A MEGF8	5.02e-05	3	143	2	20410128
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	5.02e-05	3	143	2	9154127
Pubmed	ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production.	ERVK13-1 GNMT	5.02e-05	3	143	2	38003554
Pubmed	Aberrant Amygdala-Dependent Cued Fear Memory in Na+/Ca2+ Exchanger 1 Heterozygous Mice.	SLC8A2 SLC8A1	5.02e-05	3	143	2	30324228
Pubmed	Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.	MTM1 MTMR2	5.02e-05	3	143	2	28589938
Pubmed	Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.	SLC8A2 SLC8A1	5.02e-05	3	143	2	21858195
Interaction	RAD51D interactions	RAD51C IKZF3 IPO8 ZBTB42 FANCA BLM IMMT	5.36e-06	102	134	7	int:RAD51D
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.73e-12	149	143	11	chr17q12
Cytoband	2p23-p22	SNX17 SLC8A1	9.63e-06	2	143	2	2p23-p22
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	1.54e-05	99	143	5	17q12
GeneFamily	Phosphoinositide phosphatases	INPP5K MTM1 MTMR2	5.16e-04	32	89	3	1079
GeneFamily	Trace amine receptors	TAAR5 TAAR8	8.43e-04	9	89	2	188
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM5 ZSWIM4	8.43e-04	9	89	2	90
GeneFamily	Septins	SEPTIN8 SEPTIN10	1.80e-03	13	89	2	732
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTM1 MTMR2	2.41e-03	15	89	2	903
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	5.55e-09	90	134	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ZSWIM5 TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	1.03e-06	213	134	10	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ZSWIM5 TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	1.03e-06	213	134	10	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TYK2 FHOD1 TBC1D3G TBC1D3K TBC1D3F	1.75e-06	281	134	11	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TYK2 FHOD1 TBC1D3G TBC1D3K TBC1D3F	1.75e-06	281	134	11	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	2.37e-05	242	134	9	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D PAQR5 TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	3.68e-05	320	134	10	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#3_top-relative-expression-ranked_1000	DHX36 MAL WASHC4 IPO8 PAQR5 HERC1	1.70e-04	129	134	6	gudmap_developingKidney_e14.5 whole kidney - wildtype_1000_k3
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	IKZF3 AHCTF1 ENPP4 ITGA4 KMT2D MTM1 DOP1B ZNF292	1.55e-07	185	143	8	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 RARS1 ADGRA2 TRIM23 NLRP3 BLM IQGAP3	1.86e-06	179	143	7	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	IKZF3 AHCTF1 SIK3 EPG5 KMT2C ATF7IP HERC1	2.57e-06	188	143	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	background-B_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	DOCK2 IKZF3 IRF4 ATF7IP GZMB ITM2C RASGRP2	2.57e-06	188	143	7	9acb7a95e3095f15918a5d094107d1d565a42842
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF3 IRF4 ATG2A ITGA4 ATF7IP GZMB ITM2C	3.17e-06	194	143	7	b0a7f5ca0c6f4f5764a8b35b5de80d82b828c66c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IKZF3 MYO6 ATG2A ITGA4 PTCH1 LLGL2 GZMB	3.51e-06	197	143	7	2b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IKZF3 MYO6 ATG2A ITGA4 PTCH1 LLGL2 GZMB	3.51e-06	197	143	7	f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF3 MYO6 ATG2A ITGA4 PTCH1 LLGL2 GZMB	3.51e-06	197	143	7	e70e7d97823a762def3970d94a0e897981a6c922
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF3 MYO6 ATG2A ITGA4 PTCH1 LLGL2 GZMB	3.51e-06	197	143	7	bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Severe / Disease, condition lineage and cell class	IKZF3 MYO6 ATG2A ITGA4 PTCH1 LLGL2 GZMB	3.87e-06	200	143	7	31859b8db7ea17e48b7b54e92f0d76aeb755e7ca
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNMT SMG7 MTM1 PLD2 ZSWIM4 ENOX2	1.51e-05	164	143	6	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HCN3 PAQR5 TWIST2 SEMA3A GZMB	1.79e-05	100	143	5	cb0deaf1c33d2789417e93cc01d94e34a611d20a
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAL PKDREJ TRIM23 SLC8A1 AEBP1 IMMT	2.72e-05	182	143	6	ccfee33de0faebbe69099d4ff3c3971f6a708b99
ToppCell	IPF-Lymphoid-ILC_A\|IPF / Disease state, Lineage and Cell class	IKZF3 ITGA4 GZMB ITM2C PRKX PRKY	2.81e-05	183	143	6	49bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	AHCTF1 ENPP4 ITGA4 MTM1 DOP1B ZNF292	3.08e-05	186	143	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_int\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK2 IKZF3 IRF4 ITGA4 BLM ITM2C	3.27e-05	188	143	6	599195338070ac6b79bd114609d9e10cac4f1df4
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK2 IKZF3 IRF4 ITGA4 FANCA BLM	3.57e-05	191	143	6	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	IKZF3 AHCTF1 ENPP4 ITGA4 DOP1B ZNF292	3.57e-05	191	143	6	9454f642c3621370fa23640b631301346b300950
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	IRF4 ATG2A PDLIM4 SRRT GZMB ITM2C	3.57e-05	191	143	6	2ffd40ebf1d63e61a97208ddcbeb6a86e409f9d8
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF3 IRF4 ITGA4 LLGL2 GZMB ITM2C	3.78e-05	193	143	6	778fcf8448e81fe18972d97ea8a30ab036d16fe5
ToppCell	Nasal_Brush-Immune\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DOCK2 IRF4 ITGA4 NLRP3 SLC8A1 RASGRP2	3.89e-05	194	143	6	3135bc4a8112c5dee108e3b8e775f508b65191f1
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	IRF4 ITGA4 BLM GZMB ITM2C HERC1	4.01e-05	195	143	6	4b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCell	COVID-19-kidney-Proliferating_T_cell\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK2 IKZF3 IRF4 ITGA4 FANCA BLM	4.01e-05	195	143	6	7e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCell	COVID-19_Severe-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	TWIST2 RIOK3 ENPP4 CHI3L1 OR6N1 DOP1B	4.12e-05	196	143	6	16359a56297f0558fc93fa52563cce0c53def167
ToppCell	5'-Airway_Nasal-Immune_Myeloid\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IRF4 ITGA4 NLRP3 SLC8A1 GZMB ITM2C	4.12e-05	196	143	6	9c942bf9fc78caa173d2c7de5fe4c17f076c623b
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 IKZF3 PLEKHG7 IRF4 ITGA4 RASGRP2	4.24e-05	197	143	6	ccabb976b5d4800e87e550640454a893fdb3b1b6
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_Tem\|COVID-19_Severe / Disease group, lineage and cell class	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.24e-05	197	143	6	f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCell	COVID-19_Severe-Neu_2\|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients	TWIST2 RIOK3 ENPP4 CHI3L1 OR6N1 DOP1B	4.24e-05	197	143	6	945f19475905cdedf232315eea1076ca0b753b67
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.36e-05	198	143	6	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	COVID-19_Moderate-CD8+_Tem\|World / disease group, cell group and cell class	IKZF3 MYO6 ATG2A ITGA4 LLGL2 GZMB	4.36e-05	198	143	6	1d12be256af028c88e31fb535068bae16b7bd48e
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 IKZF3 PLEKHG7 IRF4 ITGA4 RASGRP2	4.36e-05	198	143	6	4aa4ae2571effcfb6eb6923f7173cd3e7e4af9ef
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 IKZF3 PAQR5 SLC6A3 PRKX PGBD5	4.36e-05	198	143	6	cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.36e-05	198	143	6	76aff381403bc5a8a9cc73eb1e5dbdc0bac7de6c
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 IKZF3 PAQR5 SLC6A3 PRKX PGBD5	4.36e-05	198	143	6	d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.36e-05	198	143	6	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.36e-05	198	143	6	df399674345c45738d765a8354ea8d1484572c34
ToppCell	COVID-19_Mild-Lymphoid_T/NK-gd_T\|COVID-19_Mild / Disease group, lineage and cell class	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.36e-05	198	143	6	6aea5d00c417708f05b6d2dfe5a962d80864f8eb
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T\|COVID-19_Mild / Disease, condition lineage and cell class	IKZF3 MYO6 ATG2A PTCH1 LLGL2 GZMB	4.61e-05	200	143	6	6560753d3df2f87860b52052d4881aa45410f666
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF3 MYO6 ATG2A ITGA4 LLGL2 GZMB	4.61e-05	200	143	6	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	severe-CD8+_Tem\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF3 MYO6 ATG2A ITGA4 LLGL2 GZMB	4.61e-05	200	143	6	aaa2cd326dc15dee2fd975ca133359c5826f6a75
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 IKZF3 MAL ITGA4 PRKX RASGRP2	4.61e-05	200	143	6	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	mild-CD8+_Tem\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF3 MYO6 ATG2A ITGA4 LLGL2 GZMB	4.61e-05	200	143	6	a7870c5728b2c17d1d0e4fe728599f186966861b
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	IKZF3 MYO6 ENPP4 PTCH1 LLGL2 GZMB	4.61e-05	200	143	6	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	facs-Heart-RV-18m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIOK3 PTCH1 TRIM23 WDR17 ZMYND12	7.26e-05	134	143	5	d101e16cb87ff72c81324406fe7e3d70ed8f45df
ToppCell	facs-Heart-RV-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIOK3 PTCH1 TRIM23 WDR17 ZMYND12	7.26e-05	134	143	5	0c63c8b3c748d29c59fcb27d03276ba4f6a0d6b2
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZDHHC2 DOCK3 GNMT NETO2 GZMB	9.55e-05	142	143	5	d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Epi-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZDHHC2 DOCK3 GNMT NETO2 GZMB	9.55e-05	142	143	5	a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PDE6C HTR4 TMEM114 P2RY2	1.11e-04	77	143	4	afe990041849a68fd75e0c11b633a7b90fefade1
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PDE6C HTR4 TMEM114 P2RY2	1.11e-04	77	143	4	ec8f625cae561986ed27dfaefa8f822dd1c4fba1
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PDE6C HTR4 TMEM114 P2RY2	1.11e-04	77	143	4	af7e1e76db33b115238b6fc61fc0dd86aab8e49d
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZDHHC2 IKZF3 GZMB OTULINL ENOX2	1.27e-04	151	143	5	7270b8bbfae659e110bd9d513b602120b25de3dd
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	MAL IRF4 AEBP1 GZMB ITM2C	1.48e-04	156	143	5	19472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5\|TCGA-Endometrium / Sample_Type by Project: Shred V9	DOCK3 CTCFL PRKCI ITM2C ZSWIM4	1.53e-04	157	143	5	59450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IKZF3 ITGA4 LLGL2 GZMB ITM2C	1.72e-04	161	143	5	a480107b1c7773f2081afca2657e0b7fc88a5645
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB ITGA4 TRIM23 BLM IQGAP3	1.77e-04	162	143	5	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 SLC8A1 SCN1B FHOD1 PLD2	1.82e-04	163	143	5	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 SLC8A1 SCN1B FHOD1 PLD2	1.82e-04	163	143	5	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HCN3 PAQR5 TWIST2 SEMA3A	1.85e-04	88	143	4	1ca0e16981e88030987412e12838a9797b97b9c9
ToppCell	droplet-Kidney-nan-21m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.87e-04	164	143	5	d4cdcd61e8c28b3fb912cef8837cc1a49678a729
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	DOCK3 MAL CTCFL PRKCI ITM2C	1.87e-04	164	143	5	08c725548e751f815b4df778607270498204b353
ToppCell	367C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MAL IRF4 AEBP1 GZMB ITM2C	1.87e-04	164	143	5	95b800c78871354c859abaa832d778786ef7bcc0
ToppCell	droplet-Kidney-nan-21m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.93e-04	165	143	5	9852a4cb680af39c92c7d2d5e5fa8dc04e6602aa
ToppCell	droplet-Kidney-nan-21m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.93e-04	165	143	5	c629ed33ff14834c32cc1a91116fb079f7aaa94d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC16B IKZF3 GZMB OTULINL OCSTAMP	1.98e-04	166	143	5	d80c2522cf314d56730d60f160b1247933443378
ToppCell	droplet-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.98e-04	166	143	5	961f93f7fb127f449cb1021f6ba73775dc666c53
ToppCell	droplet-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.98e-04	166	143	5	fc71e871084299fb6f006c76f91e72026a290149
ToppCell	droplet-Kidney-nan-3m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA HEXB NLRP3 PDLIM4 OTULINL	1.98e-04	166	143	5	f55fc58572ae6080ac2758462a6b1f3f8b5a93f3
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC16B IKZF3 GZMB OTULINL OCSTAMP	1.98e-04	166	143	5	f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 ITGA4 F10 NLRP3 P2RX2	2.04e-04	167	143	5	e85d97f8b0127663a3295db2b22b8488c0148455
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 ITGA4 F10 NLRP3 P2RX2	2.04e-04	167	143	5	ac21c7112b592e30473e693a2bbee81ff0bb0160
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	IRF4 NAA25 GZMB ITM2C DOP1B	2.04e-04	167	143	5	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	droplet-Tongue-TONGUE-1m-Myeloid-Langerhans_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 ITGA4 F10 NLRP3 P2RX2	2.04e-04	167	143	5	a54e200789db14f41c9fc8d21cd7fa7cedde77ad
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 IRF4 ITGA4 NLRP3 OCSTAMP	2.10e-04	168	143	5	84977db9d71e59208727885320cc18d80d064380
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MYO6 ENPP4 ITGA4 PTCH1 GZMB	2.10e-04	168	143	5	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK3 FANCA BLM NETO2 PGBD5	2.15e-04	169	143	5	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	367C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	MAL IRF4 AEBP1 GZMB ITM2C	2.21e-04	170	143	5	fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	IRF4 NAA25 GZMB ITM2C DOP1B	2.27e-04	171	143	5	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	Control-Myeloid-Mast\|World / Disease state, Lineage and Cell class	IKZF3 SLC6A3 ZNF462 ITM2C PRKX	2.27e-04	171	143	5	ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	DOCK2 IKZF3 IRF4 ITGA4 NLRP3	2.34e-04	172	143	5	c477008444d2d71071177807870d7455e90c2fad
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA ITGA4 F10 SLC8A1 OTULINL	2.34e-04	172	143	5	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK2 IKZF3 ITGA4 LLGL2 OCSTAMP	2.40e-04	173	143	5	a693772987f1baee533dd0bd285a3c7b5619a73b
ToppCell	PND03-Immune\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOCK2 HEXB ITGA4 F10 OTULINL	2.40e-04	173	143	5	8543304ae72f781da311deca05871098eabc4a19
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	MAL MYO1H CHI3L1 ZSWIM4 MED12	2.40e-04	173	143	5	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	IRF4 AEBP1 P2RX2 GZMB ITM2C	2.53e-04	175	143	5	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	droplet-Marrow-nan-18m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA AKR1A1 F10 ITM2C OTULINL	2.53e-04	175	143	5	510c46bfd250ef83fcad8f6b01efbcca9d71a9a2
ToppCell	CF-Lymphoid-pDC\|CF / Disease state, Lineage and Cell class	IRF4 AEBP1 P2RX2 GZMB ITM2C	2.60e-04	176	143	5	dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 IKZF3 IRF4 OTULINL RASGRP2	2.60e-04	176	143	5	ea27e18407b8a13e8212830da859efeb8f158690
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	DOCK2 IKZF3 ITGA4 ATF7IP RASGRP2	2.60e-04	176	143	5	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 IKZF3 IRF4 OTULINL RASGRP2	2.60e-04	176	143	5	bfbab3c5b738b3b0b1540f2059d0245fbd8c0031
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	DOCK2 IKZF3 IRF4 ITGA4 RASGRP2	2.67e-04	177	143	5	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 IKZF3 GZMB OTULINL RASGRP2	2.67e-04	177	143	5	f1efd9c3074d5635700fe7fbebf3dd0b1e0a84f1
ToppCell	droplet-Marrow-nan-21m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXA AKR1A1 F10 ITM2C OTULINL	2.67e-04	177	143	5	b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCell	LPS-antiTNF-Lymphocytic_NKT\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 IKZF3 GZMB OTULINL RASGRP2	2.81e-04	179	143	5	ecea75c568911ff56939c9f67ab901497bd4356c
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAD51C ENPP4 ZBTB42 SEPTIN10 IQGAP3	2.81e-04	179	143	5	327cc39161741ddbc4e8d45b9b3d30b3ce508929
ToppCell	moderate-Myeloid-pDC\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IRF4 AEBP1 GZMB ITM2C RASGRP2	2.88e-04	180	143	5	a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell	NS-moderate-d_16-33-Myeloid-pDC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IRF4 AEBP1 GZMB ITM2C RASGRP2	2.88e-04	180	143	5	144818e69613296cde43f29cb8c20899c670b319
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	FKBP9 NLRP3 SLC8A1 TRPM5 OR6C70	2.96e-04	181	143	5	921e917f83105896ad8918dc134b871708024021
ToppCell	NS-moderate-d_0-4-Lymphoid-CTL\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DOCK2 IKZF3 ITGA4 GZMB RASGRP2	2.96e-04	181	143	5	7fb3c1d29c542a3cea7fa654432d501d82df138f
ToppCell	HSPCs-Mono_prog.\|HSPCs / Lineage and Cell class	HEXA F10 NLRP3 OTULINL RASGRP2	2.96e-04	181	143	5	a188f0d22426d8723ba394d94d20431afa6722a7
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PAQR5 ZNF462 EXD3 AEBP1 ITM2C	2.96e-04	181	143	5	f0d81ae74d3f32979624a94b2ef93774831a7970
Disease	Malignant neoplasm of breast	RAD51C MAL ZSWIM5 INPP5K NUP98 SIK3 PKDREJ EPG5 SEMA3A SLC6A3 NAA25 KMT2D LLGL2 GZMB PLD2 CDC27 MED12	5.19e-06	1074	130	17	C0006142
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	1.93e-05	2	130	2	DOID:0080598 (implicated_via_orthology)
Disease	Malignant Cystosarcoma Phyllodes	KMT2D MED12	1.91e-04	5	130	2	C0600066
Disease	Phyllodes Tumor	KMT2D MED12	1.91e-04	5	130	2	C0010701
Disease	Acute monocytic leukemia	RAD51C FANCA BLM	2.02e-04	26	130	3	C0023465
Disease	Miller Dieker syndrome	RAD51C FANCA BLM	2.81e-04	29	130	3	C0265219
Disease	small cell carcinoma (is_marker_for)	IKZF3 CHI3L1	2.86e-04	6	130	2	DOID:0050685 (is_marker_for)
Disease	leukemia (is_marker_for)	IRF4 DAXX	3.99e-04	7	130	2	DOID:1240 (is_marker_for)
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTM1 MTMR2	6.80e-04	9	130	2	DOID:0111225 (implicated_via_orthology)
Disease	level of Triacylglycerol (51:3) in blood serum	SNX17 SIK3	8.47e-04	10	130	2	OBA_2045163
Disease	Paranoia	TYK2 SLC6A3	1.03e-03	11	130	2	C1456784
Disease	Ashkenazi Jewish disorders	HEXA BLM	1.03e-03	11	130	2	cv:CN118946
Disease	esophagus squamous cell carcinoma (is_implicated_in)	FANCA KMT2C KMT2D	1.04e-03	45	130	3	DOID:3748 (is_implicated_in)
Disease	Leukemia, Myelocytic, Acute	RAD51C NUP98 FANCA BLM KMT2C	1.04e-03	173	130	5	C0023467
Disease	hair colour measurement, hair morphology measurement	IRF4 FANCA	1.24e-03	12	130	2	EFO_0007821, EFO_0007822
Disease	coagulation factor X measurement	SNX17 F10	1.46e-03	13	130	2	EFO_0020265
Disease	Fanconi anemia	RAD51C FANCA	1.69e-03	14	130	2	cv:C0015625
Disease	Chronic Lymphocytic Leukemia	IKZF3 IRF4 ITGA4	1.85e-03	55	130	3	C0023434
Disease	triacylglycerol 52:3 measurement	SNX17 SIK3	1.95e-03	15	130	2	EFO_0010415
Disease	level of Triacylglycerol (53:3) in blood serum	SNX17 SIK3	1.95e-03	15	130	2	OBA_2045165
Disease	Hepatitis	GNMT GZMB	1.95e-03	15	130	2	C0019158
Disease	eosinophil count	RAD51C DOCK3 IKZF3 HTR4 IRF4 SIK3 ITGA4 SEPTIN8 SLC9C1 NAA25 PPP4C ATF7IP PRKCI OTULINL ZNF292	2.36e-03	1488	130	15	EFO_0004842
Disease	lymphocyte percentage of leukocytes	IKZF3 HTR4 IRF4 ITGA4 NLRP3 TYK2 SLC8A1 ITM2C ZNF292	2.80e-03	665	130	9	EFO_0007993
Disease	Feeding difficulties	RARS1 ZNF292	2.81e-03	18	130	2	C0232466
Disease	glucose homeostasis measurement, acute insulin response measurement	ZDHHC2 P2RY2	2.81e-03	18	130	2	EFO_0006831, EFO_0006896
Disease	Adrenocortical carcinoma	DAXX MED12	2.81e-03	18	130	2	C0206686
Disease	Bone marrow hypocellularity	RAD51C FANCA	2.81e-03	18	130	2	C1855710
Disease	Seizures	HEXB RARS1 SLC8A1 CLPB ZNF292	2.85e-03	218	130	5	C0036572
Disease	macrophage inflammatory protein 1b measurement	DOCK3 TBC1D3 TBC1D3B TBC1D3F	3.13e-03	136	130	4	EFO_0008219
Disease	skin sensitivity to sun	IRF4 FANCA	3.14e-03	19	130	2	EFO_0004795
Disease	MYELODYSPLASTIC SYNDROME	RAD51C FANCA BLM	3.26e-03	67	130	3	C3463824
Disease	CCL4 measurement	TBC1D3 TBC1D3F	3.47e-03	20	130	2	EFO_0004751
Disease	freckles	IRF4 FANCA	3.47e-03	20	130	2	EFO_0003963
Disease	attention deficit hyperactivity disorder (is_implicated_in)	DOCK3 SLC6A3	3.47e-03	20	130	2	DOID:1094 (is_implicated_in)
Disease	lifestyle measurement	DOCK3 IPO8 HTR4 RIOK3 PTCH1	3.93e-03	235	130	5	EFO_0010724
Disease	basophil count, eosinophil count	DOCK3 HTR4 IRF4 SIK3 SLC9C1	4.37e-03	241	130	5	EFO_0004842, EFO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDTIYYHRELLCYSL	AGBL5	186	Q8NDL9
DRHEFYELLLNYSRC	EPG5	286	Q9HCE0
DALHLQCFSAVLYIY	SLC4A9	406	Q96Q91
TLCSEFIYSLDYIEH	ERVK13-1	106	Q9NX77
RYCSAVFHERYALIQ	CTCFL	461	Q8NI51
HCLYTNDITRVLYTF	ADGRA2	416	Q96PE1
FSYLHTNCLELSFYL	AEBP1	861	Q8IUX7
RYLCAANIDFYNHLD	GYS2	211	P54840
DLRHYYDSTIELCVG	GZMB	176	P10144
SLHFGREFVDCFLYL	C14orf28	81	Q4W4Y0
SYVECLLYSFHQLGR	API5	341	Q9BZZ5
YEALYNAISCHSLDS	ANKS1A	361	Q92625
HIRFTQLDDRGIYYC	FAM187A	331	A6NFU0
YDCHREIRLSFSDTY	DDX20	756	Q9UHI6
DLIYNFGCHLTDDYR	DAXX	331	Q9UER7
YFCLEAEKATLYHRA	ATG2A	981	Q2TAZ0
LDNILSHIYYFRCRD	RAD51C	201	O43502
SHIYYFRCRDYTELL	RAD51C	206	O43502
CLLLRFADDTYTESY	RAB1A	26	P62820
DCFLLAAVAYDRYVA	OR5K2	111	Q8NHB8
ARHICYFLDYGAVNL	PAQR5	111	Q9NXK6
ELIDLHFSDYGTYLC	MDGA1	401	Q8NFP4
FLLAALSYDRYVAIC	OR6C70	111	A6NIJ9
ECYLLSSMAHDRYAA	OR8H2	111	Q8N162
IYFFHSLGATECYLL	OR6N1	101	Q8NGY5
VCFHLLKLYSDRHYD	NUP98	1491	P52948
YFLSHLSFIDLCYSS	OR8D2	61	Q9GZM6
RFYSAEISLALNYLH	PRKCI	356	P41743
RLLLCDDCDISYHTY	KMT2C	1021	Q8NEZ4
LYFADTYLKDSSRHC	LLGL2	716	Q6P1M3
HLTYLEYRSFCKILF	RASGRP2	161	Q7LDG7
AFSDCRLHICLYYRE	IRF4	246	Q15306
DYCASGLYILTLLHE	ENTPD8	401	Q5MY95
LYLAAVYGHLDCFRL	ASB12	176	Q8WXK4
LEVIRAFYSYCRDAL	DOP1B	386	Q9Y3R5
GASIEYICSYLHRLD	ENOX2	551	Q16206
STFSHLRSFLERYCD	HERC1	756	Q15751
YYEICDFLRGATVHR	CHI3L1	296	P36222
ESDYSLRAYCSILYL	MORC3	246	Q14149
YYFLGHLSFIDLCLS	OR4Q3	61	Q8NH05
FHKALYTVRSYLNCE	PDE6C	261	P51160
DRLINLDSCIDHSYY	ENPP4	246	Q9Y6X5
LDSCIDHSYYTLIDL	ENPP4	251	Q9Y6X5
RLCSEQLSSQFHYDY	DNAH12	1411	Q6ZR08
STHTCFLFAAYLARY	MEGF8	971	Q7Z7M0
LSYASYCIEHGDLEL	IMMT	691	Q16891
NEYFLITILDHLYSC	MTMR2	501	Q13614
SAERCILAYLYDLYT	MED12	966	Q93074
ILAYLYDLYTSCSHL	MED12	971	Q93074
ERLTTAIYLYCHQDF	METTL15P1	211	P0C7V9
FRLSYYPHCLASFTE	GNMT	241	Q14749
RSYLHLFYEDCAGTA	NRSN2	26	Q9GZP1
YCRLYSLSVDHFNAV	HCN3	511	Q9P1Z3
LCFLPFHVTRTLYYS	P2RY2	256	P41231
TLYYSFRSLDLSCHT	P2RY2	266	P41231
DYYSQYIRACLDHLA	IQGAP3	1506	Q86VI3
VAAICYFRRLHLYSG	OTULINL	56	Q9NUU6
SFIYHLCNGKDTYRL	ITM2C	216	Q9NQX7
GYLKRCTFHEASDLY	P2RX2	221	Q9UBL9
VEAFAAHLSYICRYD	PGBD5	441	Q8N414
CERISQSGDFLRYHY	FKBP9	271	O95302
TLYCSFDNYEDAIRL	FAM124B	141	Q9H5Z6
ISHCLLFYTYHDVTR	BLM	986	P54132
HLDCDNYTEAAYTLL	DOCK2	1231	Q92608
AENYTEAAFTLLLYC	DOCK3	1251	Q8IZD9
CYHLYNGLRASLLDD	DHX36	611	Q9H2U1
YSLLSYFHEDAAIRE	FANCA	1336	O15360
TEDEFLLCYYSNSLR	INPP5K	406	Q9BT40
ASIFHLCCISLDRYY	HTR4	106	Q13639
VDRSCATVDSYHLYA	ATF7IP	1186	Q6VMQ6
TLDAAYHCTAALFYL	MAL	86	P21145
YHCTAALFYLSASVL	MAL	91	P21145
CSIGYIYVDHLSRID	ITGA4	711	P13612
GCTALHYAVLADDYR	CLPB	266	Q9H078
LRSGEYLHNCSYFAL	AHCTF1	416	Q8WYP5
FCHTLREFALEYRTC	FHOD1	976	Q9Y613
LSEFYILTAAHCLYQ	F10	266	P00742
CTLLEEAFRRYHGYI	HEXB	91	P07686
VYRCDHCRVLFLDYV	IKZF3	451	Q9UKT9
HSEEALFLLATCYYR	CDC27	36	P30260
FYEEILSLAYSLTCH	IPO8	651	O15397
LTYAETLIDYHLCSH	CFAP221	671	Q4G0U5
SDLTFAYERLSHFRC	HEXA	491	P06865
DRFDYLFYIHCREVS	NLRP3	251	Q96P20
DLFLHTLCDYIYELA	RARS1	591	P54136
FFGDFLCRLHTYLDT	TAAR5	101	O14804
HTNYCFLTLYILEAL	SLC9C1	646	Q4G0N8
YSSVLHLCFICIDRY	TAAR8	116	Q969N4
ILIVLLRHTDCFYYN	PKDREJ	1726	Q9NTG1
RGYFFLDERLYCESH	PDLIM4	291	P50479
FYSAEIICAIEYLHS	PRKY	151	O43930
DHLTTIFYYCRSIAV	SMG7	201	Q92540
DRDYLHRPSYCDAAF	PTCH1	46	Q13635
AYDHYSAIYSLLCDR	SIK3	371	Q9Y2K2
HYYIEPSFECRFDHL	NETO2	91	Q8NC67
HCYLTDLRFDNIYAT	OCSTAMP	246	Q9BR26
CATLAIYIYQLDHRY	WDR17	56	Q8IZU2
SYHTFLLDEERSRLY	SEMA3A	56	Q14563
DYCSRFEQYLRIISH	KIAA0753	901	Q2KHM9
YCRDLSHIAALFLLY	TBC1D3L	186	B9A6J9
YFLSHLAFVDLCYSS	OR8U3	61	Q8NH85
YVLYSVHLDGFLFCR	SNX31	21	Q8N9S9
LRIVHSLDYYNTCEY	SRRT	616	Q9BXP5
ALSVGYRHIDCAAIY	AKR1A1	36	P14550
LYHECTLVHADLSEY	RIOK3	396	O14730
YCRDLSHIAALFLLY	TBC1D3B	186	A6NDS4
YCRDLSHIAALFLLY	TBC1D3H	186	P0C7X1
LRHYGYLRFDACVAD	SNX17	266	Q15036
HYALLDNSCREYLFI	VPS52	386	Q8N1B4
LYLFDRNGVCLHYSE	TRAPPC1	6	Q9Y5R8
DIFYCAHVVALSLYR	ZSWIM5	241	Q9P217
YERLALDLFSECYSN	TRPM5	576	Q9NZQ8
ILDHLYSCRFGTFLF	MTM1	466	Q13496
YCRDLSHIAALFLLY	TBC1D3F	186	A6NER0
AYLSVDFYRLCEASV	SLC6A3	296	Q01959
SGDYECHVYRLLFFE	SCN1B	116	Q07699
CGRIFSEAYLLYDHE	ZNF292	786	O60281
SLFDYHDTRIHVCLY	SEPTIN8	141	Q92599
YCRDLSHIAALFLLY	TBC1D3E	186	A0A087X179
VYIAYSAAAFREALC	TMEM114	156	B3SHH9
FYSAEIICAIEYLHS	PRKX	151	P51817
TYHDSRIHVCLYFIS	SEPTIN10	166	Q9P0V9
RLADYGLVSQALHYC	SEC16B	636	Q96JE7
ARYHLANDIYFASCA	ZMYND12	191	Q9H0C1
VLAACSVYFHLFYRD	ZBTB42	41	B2RXF5
HARHLESYEILLDCY	WASHC4	646	Q2M389
DIDAYYTHCLAASRT	ZNF462	1721	Q96JM2
LFTSECTYFLDHLLV	PLEKHG7	296	Q6ZR37
YCRDLSHIAALFLLY	TBC1D3D	186	A0A087WVF3
LAYSLLYCLFIAATD	ZDHHC2	176	Q9UIJ5
SCIRAYFYDLHETLC	TRIM23	286	P36406
YCRDLSHIAALFLLY	TBC1D3G	186	Q6DHY5
YCRDLSHIAALFLLY	TBC1D3	186	Q8IZP1
RYCTEIFDYLSLSAI	PPP4C	141	P60510
AILHFTYRTLCRGEY	PLD2	701	O14939
YCRDLSHIAALFLLY	TBC1D3K	186	A0A087X1G2
QALLEDSCHYLLYSL	TMEM33	86	P57088
DSCHYLLYSLIFVNS	TMEM33	91	P57088
YCRDLSHIAALFLLY	TBC1D3I	186	A0A087WXS9
YCRDLSHIAALFLLY	TBC1D3C	186	Q6IPX1
DGYFRLTADSSHYLC	TYK2	421	P29597
DLFYCAHVVALSLYR	ZSWIM4	161	Q9H7M6
TSCSYVAHERLSYAF	TWIST2	131	Q8WVJ9
RLLLCDDCDISYHTY	KMT2D	1441	O14686
LLYIFFSSLEAYCHI	SLC8A1	956	P32418
YILFASLEAYCHIRG	SLC8A2	906	Q9UPR5
EFRLLHYAGEVTYCT	MYO1H	511	Q8N1T3
YAAADAYCLLEVHQA	EXD3	551	Q8N9H8
EERNYHIFYRLCAGA	MYO6	241	Q9UM54
LQFSDYYCLLAVHAL	NAA25	461	Q14CX7