Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	mRNA cleavage and polyadenylation specificity factor complex	TUT1 CSTF2 PIP5K1A CSTF2T SYMPK	2.41e-06	26	178	5	GO:0005847
GeneOntologyCellularComponent	mRNA cleavage factor complex	TUT1 CSTF2 PIP5K1A CSTF2T SYMPK	6.01e-06	31	178	5	GO:0005849
Domain	CSTF2_hinge	CSTF2 CSTF2T	9.03e-05	2	178	2	PF14327
Domain	CSTF_C	CSTF2 CSTF2T	9.03e-05	2	178	2	PF14304
Domain	CSTF2_hinge	CSTF2 CSTF2T	9.03e-05	2	178	2	IPR025742
Domain	CSTF_C	CSTF2 CSTF2T	9.03e-05	2	178	2	IPR026896
Domain	DUF2371_TMEM200	TMEM200B TMEM200C	2.69e-04	3	178	2	IPR018787
Domain	DUF2371	TMEM200B TMEM200C	2.69e-04	3	178	2	PF10177
Domain	Ldl_recept_b	LRP1 LRP5 NID1	2.87e-04	14	178	3	PF00058
Domain	LDLRB	LRP1 LRP5 NID1	2.87e-04	14	178	3	PS51120
Domain	LY	LRP1 LRP5 NID1	3.56e-04	15	178	3	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP5 NID1	3.56e-04	15	178	3	IPR000033
Domain	-	GTF2IRD2B GTF2IRD2	5.35e-04	4	178	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.35e-04	4	178	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.35e-04	4	178	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.35e-04	4	178	2	IPR004212
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	AGPAT5 GRWD1 EIF4H TCP1 POLR2D RCC1 SPAG9 LASP1 NCKAP5L BCL2L12 TUBB3 LSR RBM22 PIN1 NFKB2 YLPM1 CSTF2 LRP5 HSPA2 ARHGAP21 CSTF2T SDHA SYMPK	6.06e-10	922	181	23	27609421
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	HDAC5 GRWD1 BCAS3 PNO1 UPF3A PRKRIP1 RAB11FIP1 BLZF1 NCKAP5L SPICE1 PASK TUBB3 AP2A1 NFKB2 TUBGCP3 EIF2B2 EID1 KATNIP HOOK2 BECN1 ARHGAP21 ATG16L2	2.76e-08	1038	181	22	26673895
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LIAS SIN3B ZNF775 TCP1 FXR2 VPS13C SPAG9 PPFIA3 THBS4 CSNK1G2 CSTF2 ALDH18A1 PRDM13 BOD1L1 UTRN TMEM200C SDHA SYMPK	6.73e-08	736	181	18	29676528
Pubmed	Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity.	GLI1 SMO IHH	1.39e-07	3	181	3	35835905
Pubmed	Indian Hedgehog links obesity to development of hepatocellular carcinoma.	GLI1 SMO IHH	1.39e-07	3	181	3	30470823
Pubmed	Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.	GLI1 SMO IHH	5.52e-07	4	181	3	22486854
Pubmed	Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.	GLI1 SMO IHH	5.52e-07	4	181	3	27694322
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	LCA5 AGPAT5 EIF4H TCP1 FXR2 VPS13C GPATCH1 SH3GL2 KLC2 EFHD2 LASP1 CCDC77 NCKAP5L PPP1R8 GCAT PIN1 HSPA2 ARHGAP21	5.83e-07	853	181	18	28718761
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GPD2 ELP5 TCP1 POLR2D RCC1 SPAG9 PPFIA3 RAB11FIP1 CCDC77 NCKAP5L TERF2 SPICE1 PPP1R8 SLC12A4 YLPM1 CSTF2 ALDH18A1 HSPA2 UTRN SYMPK	6.53e-07	1049	181	20	27880917
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	GRWD1 TCP1 RBM10 EFHD2 RCC1 LASP1 RAB11FIP1 PIN1 NFKB2 EIF2B2 YLPM1 OSBPL8 CSTF2 CSTF2T SDHA ATG16L2	9.26e-07	701	181	16	30196744
Pubmed	Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes.	TUBB3 GLI1 SMO IHH	1.23e-06	16	181	4	33328171
Pubmed	A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.	TUT1 PIP5K1A SYMPK	1.38e-06	5	181	3	18288197
Pubmed	An Nfic-hedgehog signaling cascade regulates tooth root development.	NFIC GLI1 IHH	1.38e-06	5	181	3	26293299
Pubmed	Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.	GLI1 SMO LHX5 IHH	2.59e-06	19	181	4	20400693
Pubmed	alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.	TUBB3 GLI1 SMO IHH	2.59e-06	19	181	4	16543460
Pubmed	CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.	TUT1 CSTF2 PIP5K1A	2.74e-06	6	181	3	18305108
Pubmed	Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.	GLI1 SMO IHH	2.74e-06	6	181	3	25362352
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 IHH GLIS1	2.74e-06	6	181	3	12385751
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RBM10 KLC2 RCC1 SPAG9 ZNF217 TERF2 SPICE1 PASK BAZ2A NFIC CHTF18 ZNF516 YLPM1 RBM6 CSTF2T SYMPK	3.30e-06	774	181	16	15302935
Pubmed	Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton.	GLI1 SMO IHH	4.78e-06	7	181	3	14973297
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARHGEF19 BCAS3 POLG L1CAM PRKRIP1 C8orf58 CELSR3 SLC12A4 AP2A1 CSNK1G2 GLI1 NFKB2 ZNF516 LRP5 PCNX1 ARHGAP21 SDHA ARHGAP33 SYMPK	5.63e-06	1105	181	19	35748872
Pubmed	Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.	FXR2 TUBB3 GLI1 HSPA2	8.24e-06	25	181	4	31462707
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	EIF4H TCP1 FXR2 WFS1 KLC2 PNO1 ZNF217 UPF3A LASP1 TERF2 SPICE1 TUBB3 RBM22 AP2A1 ZNF608 PIK3C2A CHTF18 ALDH18A1 UBAC2 SDHA	8.77e-06	1247	181	20	27684187
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EIF4H FXR2 RBM10 KLC2 LASP1 RBM22 RBM6 CSTF2 RAB37	9.17e-06	258	181	9	37794589
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	GRWD1 FXR2 RBM10 EFHD2 RCC1 LASP1 KRT80 PPP1R8 TUBB3 AP2A1 PIK3C2A YLPM1 CSTF2 ALDH18A1	1.04e-05	660	181	14	32780723
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HDAC5 EIF4H RBM10 CAMTA2 BAZ2A PPIP5K1 KATNIP RIMBP2 BOD1L1 RUBCN ARHGAP21	1.05e-05	407	181	11	12693553
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	GRWD1 TCP1 BCAS3 KLC2 RCC1 TUBB3 AP2A1 CSTF2 UTRN CSTF2T SYMPK	1.15e-05	411	181	11	36652389
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TNK1 BCAS3 USP43 KLC2 RAB11FIP1 NCKAP5L SPICE1 LSR PIK3C2A OSBPL8 BOD1L1 PLCH1 BECN1 UTRN ARHGAP21 DOP1A	1.25e-05	861	181	16	36931259
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	RAB11FIP1 ITGA7 BLZF1 LSR AP2A1 OSBPL8 PIP5K1A PLCH1 UTRN ARHGAP21 SDHA	1.43e-05	421	181	11	36976175
Pubmed	Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.	TUBB3 GLI1 SMO IHH	1.52e-05	29	181	4	31845891
Pubmed	Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling.	GLI1 SMO IHH	1.62e-05	10	181	3	18083924
Pubmed	Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.	GLI1 SMO IHH	1.62e-05	10	181	3	11311154
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	GPD2 AEN GRWD1 TCP1 RBM10 PNO1 RCC1 ZNF217 LASP1 RBM22 NFIC NFKB2 YLPM1 RBM6 ALDH18A1 BOD1L1 SYMPK	1.80e-05	989	181	17	36424410
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ELP5 FXR2 RBM10 SH3GL2 CALCOCO1 KLC2 USHBP1 PIN1 CSTF2 KLHL42 BECN1 HSPA2 CSTF2T	2.00e-05	608	181	13	16713569
Pubmed	Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.	GLI1 SMO IHH	2.22e-05	11	181	3	11748145
Pubmed	PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.	PIK3C2A GLI1 SMO	2.22e-05	11	181	3	24697898
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF775 RBM10 ZBTB8B LASP1 THAP4 ZNF750 LSR BAZ2A NFKB2 ZNF516 EIF2B2 AEBP2 KLHL42 ZNF679 GLIS1	2.38e-05	808	181	15	20412781
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	HDAC5 TOGARAM1 SPAG9 PPFIA3 PASK ZNF608 OSBPL8 PCNX1	2.54e-05	225	181	8	12168954
Pubmed	A family of splice variants of CstF-64 expressed in vertebrate nervous systems.	CSTF2 CSTF2T	2.69e-05	2	181	2	19284619
Pubmed	Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein.	CSTF2 CSTF2T	2.69e-05	2	181	2	12773396
Pubmed	Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.	CSTF2 CSTF2T	2.69e-05	2	181	2	17029590
Pubmed	HDAC5-Mediated Acetylation of p100 Suppresses Its Processing.	HDAC5 NFKB2	2.69e-05	2	181	2	36156247
Pubmed	A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.	GLI1 SMO	2.69e-05	2	181	2	29463581
Pubmed	Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.	ZNF217 ZNF516	2.69e-05	2	181	2	29846698
Pubmed	Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.	ITGA7 UTRN	2.69e-05	2	181	2	19729483
Pubmed	Hedgehog pathway proteins SMO and GLI expression as prognostic markers in head and neck squamous cell carcinoma.	GLI1 SMO	2.69e-05	2	181	2	30861166
Pubmed	Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.	CSTF2 CSTF2T	2.69e-05	2	181	2	24149845
Pubmed	Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs.	SMO IHH	2.69e-05	2	181	2	10208865
Pubmed	Establishment of a Gorlin syndrome model from induced neural progenitor cells exhibiting constitutive GLI1 expression and high sensitivity to inhibition by smoothened (SMO).	GLI1 SMO	2.69e-05	2	181	2	31758086
Pubmed	Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.	GLI1 SMO	2.69e-05	2	181	2	20603613
Pubmed	RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.	EIF4H RBM10	2.69e-05	2	181	2	33130397
Pubmed	Star-PAP RNA Binding Landscape Reveals Novel Role of Star-PAP in mRNA Metabolism That Requires RBM10-RNA Association.	RBM10 TUT1	2.69e-05	2	181	2	34576144
Pubmed	HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.	HDAC5 NPAS4	2.69e-05	2	181	2	28957664
Pubmed	Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.	SMO IHH	2.69e-05	2	181	2	20542037
Pubmed	p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation.	GLI1 IHH	2.69e-05	2	181	2	30651074
Pubmed	GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli.	GLI1 SMO	2.69e-05	2	181	2	24393163
Pubmed	Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis.	CSTF2 CSTF2T	2.69e-05	2	181	2	14681198
Pubmed	Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells.	GLI1 SMO	2.69e-05	2	181	2	28675107
Pubmed	Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury.	GLI1 SMO	2.69e-05	2	181	2	30679745
Pubmed	Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.	CAMLG TMUB1	2.69e-05	2	181	2	20582322
Pubmed	Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection.	CSTF2 CSTF2T	2.69e-05	2	181	2	16207706
Pubmed	Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.	GLI1 PIN1	2.69e-05	2	181	2	28167297
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.69e-05	2	181	2	15388857
Pubmed	Role of Sonic hedgehog signaling in cell cycle, oxidative stress, and autophagy of temozolomide resistant glioblastoma.	GLI1 BECN1	2.69e-05	2	181	2	31613002
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	GLI1 SMO IHH	2.95e-05	12	181	3	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	TUBB3 GLI1 SMO	2.95e-05	12	181	3	18417110
Pubmed	Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened.	GLI1 SMO IHH	2.95e-05	12	181	3	35472633
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SIN3B TCP1 RBM10 EFHD2 RCC1 SPAG9 BAZ2A YLPM1 CSTF2 BOD1L1 CSTF2T SYMPK	3.38e-05	549	181	12	38280479
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SIN3B TDRKH GRWD1 PNO1 EFHD2 ZNF217 RAB11FIP1 TERF2 MICU1 LSR RBM22 PIK3C2A BAZ2A CSNK1G2 OSBPL8 RBM6 PALM3 ALDH18A1 UTRN CSTF2T SDHA	3.76e-05	1497	181	21	31527615
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	GLI1 SMO IHH	3.82e-05	13	181	3	16168717
Pubmed	Temporomandibular joint formation and condyle growth require Indian hedgehog signaling.	GLI1 SMO IHH	3.82e-05	13	181	3	17191253
Pubmed	Hedgehog signals regulate multiple aspects of gastrointestinal development.	TUBB3 GLI1 IHH	3.82e-05	13	181	3	10821773
Pubmed	Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.	GLI1 SMO IHH	3.82e-05	13	181	3	18434416
Pubmed	Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium.	GLI1 SMO IHH	3.82e-05	13	181	3	22275805
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CAMLG POLG APC2 MICU1 THAP4 TUBB3 RBM22 CELSR3 AP2A1 HECTD2 YLPM1 LRP1 OSBPL8 BECN1 HSPA2 UTRN MGAT5B ARHGAP21 SDHA	4.50e-05	1285	181	19	35914814
Pubmed	Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling.	TUBB3 GLI1 IHH	4.84e-05	14	181	3	23429478
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FXR2 EFHD2 SPAG9 NCKAP5L PASK LSR AP2A1 LRP1 OSBPL8 PIP5K1A NID1 UBAC2 HOOK2 ASPRV1 UTRN SDHA	5.48e-05	974	181	16	28675297
Pubmed	Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.	GLI1 SMO GLIS1	6.02e-05	15	181	3	32561646
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SIN3B HDAC5 RCC1 ZNF217 ZNF608 ZNF516 LRP1 UTRN ARHGAP21 CSTF2T	7.37e-05	418	181	10	34709266
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	L1CAM CELSR3 AP2A1	7.39e-05	16	181	3	24305805
Pubmed	The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.	GLI1 SMO IHH	7.39e-05	16	181	3	23026747
Pubmed	Patterns of laminins and integrins in the embryonic ventricular zone of the CNS.	ITGA7 TUBB3 NID1	7.39e-05	16	181	3	17948866
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	GLI1 SMO IHH	7.39e-05	16	181	3	26932670
Pubmed	Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.	SIN3B ZNF217 BAZ2A	7.39e-05	16	181	3	12781685
Pubmed	Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.	TUBB3 GLI1 SMO	7.39e-05	16	181	3	27214567
Pubmed	Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth.	SHOX2 GLI1 SMO	7.39e-05	16	181	3	19304890
Pubmed	Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.	GLI1 SMO	8.05e-05	3	181	2	26290370
Pubmed	Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons.	GLI1 SMO	8.05e-05	3	181	2	17537964
Pubmed	CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα.	TUT1 CSTF2	8.05e-05	3	181	2	26496945
Pubmed	Sonic hedgehog signaling pathway in Myelodysplastic Syndrome: Abnormal activation and jervine intervention.	GLI1 SMO	8.05e-05	3	181	2	32526259
Pubmed	The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition.	ARSA HSPA2	8.05e-05	3	181	2	23209833
Pubmed	Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.	SMO IHH	8.05e-05	3	181	2	31382618
Pubmed	Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.	GLI1 PIN1	8.05e-05	3	181	2	34052323
Pubmed	DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.	GLI1 SMO	8.05e-05	3	181	2	26784250
Pubmed	Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy.	ITGA7 UTRN	8.05e-05	3	181	2	19179609
Pubmed	Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer.	GLI1 SMO	8.05e-05	3	181	2	22901214
Pubmed	Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).	GLI1 GLIS1	8.05e-05	3	181	2	18263616
Pubmed	The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.	GLI1 SMO	8.05e-05	3	181	2	21757753
Pubmed	Hedgehog signaling through GLI1 and GLI2 is required for epithelial-mesenchymal transition in human trophoblasts.	GLI1 IHH	8.05e-05	3	181	2	25888497
Pubmed	The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.	HDAC5 CAMTA2	8.05e-05	3	181	2	16678093
Interaction	ATG16L1 interactions	GRWD1 TCP1 VPS13C RBM10 CALCOCO1 EFHD2 RCC1 LASP1 RAB11FIP1 CCDC77 NCKAP5L SPICE1 PASK LSR SLC12A4 PIK3C2A PIN1 NFKB2 TUBGCP3 EIF2B2 YLPM1 OSBPL8 CSTF2 KATNIP CSTF2T SDHA ATG16L2	2.18e-06	1161	173	27	int:ATG16L1
Interaction	TNIP2 interactions	AGPAT5 GRWD1 EIF4H TCP1 FXR2 POLR2D RCC1 SPAG9 LASP1 NCKAP5L BCL2L12 TUBB3 LSR RBM22 PIN1 NFKB2 YLPM1 CSTF2 LRP5 ARHGAP21 CSTF2T SDHA SYMPK	7.25e-06	952	173	23	int:TNIP2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ATP8B3 SIN3B APC2 GPR108 MCOLN1 GIPC3 USHBP1 NFIC CSNK1G2 PIN1 PALM3 HOOK2 FUT5 S1PR4	3.89e-06	797	181	14	chr19p13
Cytoband	19p13.3	ATP8B3 APC2 GPR108 GIPC3 NFIC CSNK1G2 FUT5 S1PR4	5.08e-06	237	181	8	19p13.3
Cytoband	19q13.33	GRWD1 PPFIA3 C19orf81 AP2A1 SIGLEC11	6.62e-05	106	181	5	19q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	MYO1A CALCOCO1 ITGA7 NCKAP5L KRT80 BAZ2A GLI1 LRP1	2.97e-04	423	181	8	chr12q13
Cytoband	6q24	FBXO30 UTRN	4.26e-04	8	181	2	6q24
Cytoband	17p13.1	TNK1 ELP5 FXR2 USP43	1.26e-03	118	181	4	17p13.1
Cytoband	13q34	UPF3A RAB20 TUBGCP3	1.29e-03	54	181	3	13q34
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM10 GPATCH1 RBM6	3.36e-04	22	113	3	579
GeneFamily	RNA binding motif containing	EIF4H RBM10 TUT1 RBM22 RBM6 CSTF2 CSTF2T	3.84e-04	213	113	7	725
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_2H_BMDC_UP	TCTE1 ATP8B3 PSD BCAS3 RAB20 SLC12A4 BAZ2A AEBP2 LHX5 GLIS1	1.32e-06	200	180	10	M3964
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_2H_UP	HDAC5 CALCOCO1 UPF3A MICU1 ZNF516 OSBPL8 PCNX1 KATNIP S1PR4	1.06e-05	200	180	9	M6090
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C20orf144 STK35 C8orf58 THBS4 GLI1 GTF2IRD2 RUBCN	5.59e-06	167	181	7	f5bffa77061baec0ba87bd688a047595f32534db
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C TERF2 PIK3C2A YLPM1 PCNX1 RIMBP2 DOP1A	7.32e-06	174	181	7	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSD GRWD1 LPCAT4 ZNF217 SPICE1 TUBB3 CSTF2	7.59e-06	175	181	7	bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HDAC5 BCAS3 TUB TMEM200B GIPC3 NID1 GLIS1	1.30e-05	190	181	7	591310e615700321a010a4b90405cbbbbdb3aade
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH3GL2 L1CAM APC2 FBXO30 TUBB3 RIMBP2 FKBP1B	1.64e-05	197	181	7	b9478212f14b7888e3abac02995177974ac3bd17
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHOX2 CCDC80 HMX1 THBS4 LRP1 NID1 PCOLCE	1.75e-05	199	181	7	9672230aa0bc6a7289050c955f5154ca183a5159
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHOX2 CCDC80 HMX1 THBS4 LRP1 NID1 PCOLCE	1.75e-05	199	181	7	e18abe678da293bd01fae55e2f9ab6fdd643d02d
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHOX2 CCDC80 HMX1 THBS4 LRP1 NID1 PCOLCE	1.75e-05	199	181	7	1fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	USP43 RAB11FIP1 GIPC3 LSR USHBP1 S1PR4	2.07e-05	137	181	6	306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCell	Striatum-Endothelial-ENDOTHELIAL_STALK\|Striatum / BrainAtlas - Mouse McCarroll V32	USP43 RAB11FIP1 GIPC3 LSR USHBP1 S1PR4	2.07e-05	137	181	6	d37f425b13bc046baa1f8619b98a16b936f88ff6
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 SMO IHH	1.54e-05	9	170	3	DOID:0050338 (implicated_via_orthology)
Disease	gastric papillary adenocarcinoma (is_marker_for)	GLI1 SMO	3.30e-05	2	170	2	DOID:5593 (is_marker_for)
Disease	gastric tubular adenocarcinoma (is_marker_for)	GLI1 SMO	3.30e-05	2	170	2	DOID:6595 (is_marker_for)
Disease	nevoid basal cell carcinoma syndrome (is_marker_for)	GLI1 SMO	9.86e-05	3	170	2	DOID:2512 (is_marker_for)
Disease	Gastrointestinal Stromal Sarcoma	GLI1 SMO IHH SDHA	1.56e-04	47	170	4	C3179349
Disease	Gastrointestinal Stromal Tumors	GLI1 SMO IHH SDHA	1.99e-04	50	170	4	C0238198
Disease	thyroid stimulating hormone measurement	ATP8B3 AEN BCAS3 CCDC77 RAB20 TG THAP4 THBS4	5.98e-04	323	170	8	EFO_0004748
Disease	isolated growth hormone deficiency (implicated_via_orthology)	TG GH1	6.80e-04	7	170	2	DOID:0060870 (implicated_via_orthology)
Disease	atopic asthma	TDRKH HLA-DOB ZNF217 THAP4 LRP1 UBAC2	1.07e-03	199	170	6	EFO_0010638
Disease	osteoarthritis (is_marker_for)	GH1 IHH BECN1	1.07e-03	35	170	3	DOID:8398 (is_marker_for)
Disease	obsolete_red blood cell distribution width	MYO1A FXR2 BCAS3 ZNF217 MICU1 GTF2IRD2B ACSBG1 CSNK1G2 ZNF516 YLPM1 GTF2IRD2 RBM6 LRP5 HOOK2 NUTM2F RAB37 ARHGAP21	2.07e-03	1347	170	17	EFO_0005192
Disease	Hirschsprung's disease (implicated_via_orthology)	AEBP2 IHH	2.10e-03	12	170	2	DOID:10487 (implicated_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	TG ARSA	2.47e-03	13	170	2	DOID:1459 (implicated_via_orthology)
Disease	early cardiac repolarization measurement	LRP5 MGAT5B	2.87e-03	14	170	2	EFO_0004885
Disease	coronary thrombosis, GM11992	TMEM229A GPATCH1	3.76e-03	16	170	2	EFO_0001124, EFO_1000883
Disease	ocular hypertension (biomarker_via_orthology)	GLI1 SMO	4.24e-03	17	170	2	DOID:9282 (biomarker_via_orthology)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 SMO	4.24e-03	17	170	2	DOID:0060071 (biomarker_via_orthology)
Disease	intelligence, self reported educational attainment	GPD2 ARSA CELSR3 SORCS3	4.76e-03	117	170	4	EFO_0004337, EFO_0004784

Protein segments in the cluster

Peptide	Gene	Start	Entry
PMEEVSGQGLGSRTD	USHBP1	56	Q8N6Y0
EMVGTGPRGRVSELA	AEN	116	Q8WTP8
MESMAVATDGGERPG	CAMLG	1	P49069
GDTAPEQDSVERRMG	CHTF18	931	Q8WVB6
GGRRGSLEMSSDGEP	AEBP2	201	Q6ZN18
SEGPDTLGDGMRERR	ATG16L2	236	Q8NAA4
ELRGVGDPAMISSDT	ACCS	46	Q96QU6
EGLTASGSGDVMRRR	BAZ2A	531	Q9UIF9
GRRDPSSNDINGGME	AP2A1	631	O95782
GVAVSGPTKRRGMAD	CCDC77	21	Q9BR77
GLPEAGASMRERTGA	CAMTA2	961	O94983
PGASMAGSEELGLRE	BCL2L12	81	Q9HB09
DISEIESDMGSPGSR	DOP1A	1341	Q5JWR5
MEGAAAREARGTETP	GIPC3	1	Q8TF64
SRDSGVEMAVGDSPL	C8orf58	66	Q8NAV2
GETVIRAGMGDSPGR	ATP8B3	46	O60423
MGLPEERVRSGSGSR	ACSS2	1	Q9NR19
EVRGMEARGMDTRGP	CSTF2	456	P33240
MAESPSRDVVGSGTE	BCAS3	866	Q9H6U6
TGSRPDRREETSIGM	ARMCX5	146	Q6P1M9
RGSPREMIRDEGSSA	CCDC80	111	Q76M96
EGALGRDTSVEGSEM	RCC1	96	P18754
MERRFPDTVSTVGGA	RAB20	26	Q9NX57
PTRDGLGSDNIGSRM	RBM10	851	P98175
MEREISNSDGTRPVG	RBM22	121	Q9NW64
QVTLRMTTDEGTGGR	PCOLCE	126	Q15113
MTGTPGAVATRDGEA	RAB37	1	Q96AX2
SMGIGSEEKPGTGRD	PALM3	401	A6NDB9
GTGRDEAEMSPVVER	PALM3	411	A6NDB9
EEPGGSGAVMSERVS	SPAG9	11	O60271
MTAPAGPRGSETERL	MCOLN1	1	Q9GZU1
DTEITSGGMRPSRAG	ARHGEF19	86	Q8IW93
SVEMSGDRVSRPAPG	ARHGEF19	241	Q8IW93
PGAMESGRVSSIRFE	C19orf81	106	C9J6K1
LRPGDQSDSGSEGEM	TCTE1	206	Q5JU00
AQLERMGVSGPSGSD	PASK	571	Q96RG2
GGPDDRGMGSSRESR	EIF4H	131	Q15056
PRPVGERSMGSSREA	LRRC34	6	Q8IZ02
ESMGLLDPATSDGRV	GPD2	326	P43304
GREPDSRRQDGAMSS	KCTD7	6	Q96MP8
GAEPGRSRMISQEEF	LPCAT4	346	Q643R3
ASGQIPGGLVDRMTE	NLRC3	271	Q7RTR2
TSDMAEEGRVASGGP	NCKAP5L	1296	Q9HCH0
DRTVMDGGLESDGPN	FXR2	556	P51116
TVTSSPIRGAGDGME	BLZF1	11	Q9H2G9
GRRRTCETGEPMEAE	GRWD1	6	Q9BQ67
PLDMTSGTVGARVDR	ITPRID1	401	Q6ZRS4
SGIRDGRGVREIGEM	MYO1A	291	Q9UBC5
AGLRERMGRPEGEGT	HOOK2	216	Q96ED9
EEAMRRPSTADGEGD	KATNIP	1156	O60303
GRIGMDGSSRSVIVD	LRP1	3171	Q07954
MPTISEDGRRGSALG	PPFIA3	6	O75145
TGSDRVPVGGMADLN	HECTD2	711	Q5U5R9
GETPRIERAGMDGST	LRP5	171	O75197
ETEEGRRMSKAGGGR	CSNK1G2	11	P78368
LVEGEEGRMDSPSAT	KRT80	386	Q6KB66
GEGMEPERRDSQDGS	LASP1	136	Q14847
GEASDGGTMENLSRR	BECN1	101	Q14457
TIRTEVMGGPESRGV	MGAT5B	56	Q3V5L5
DPVDGRITERQFGGM	MICU1	316	Q9BPX6
GDLPQMEVGSGSREL	EID1	26	Q9Y6B2
QAEGEGSRPSMDLFR	GPATCH1	741	Q9BRR8
MSARGPAIGIDLGTT	HSPA2	1	P54652
SDPGGGIEMSEFIRE	PCNX1	121	Q96RV3
LRTGEMSGPVFTDSG	PIN1	141	Q13526
STGRDRGMVELVPAS	PIK3C2A	1176	O00443
RDGREVEGTRTRPGM	NID1	901	P14543
DSPETGEEMGRAEGA	HMX1	136	Q9NP08
GMTRPRDALGPEEEG	ABCC11	506	Q96J66
GGEMPGEAAVRRSVE	POLG	91	P54098
MGERAGSPGTDQERK	LCA5	1	Q86VQ0
LGGRLDESEMLGSTP	LHX5	261	Q9H2C1
VLTSVDRDDMPDGGA	LIAS	176	O43766
PGEAIVREGGTMALS	L1CAM	1001	P32004
RGLQEEPEVGTSMVG	GLI1	701	P08151
TRSRREGDTGGTMEI	TUBGCP3	231	Q96CW5
RSGRGPFGDSLMELD	ARSA	241	P15289
PTGRGTDELLGVMDQ	GCAT	241	O75600
GGDAGRMDTEEARPA	PNO1	41	Q9NRX1
PRMSSRIVGGRDGRD	PRSS33	31	Q8NF86
SIQGEARRGGTMETD	PIP5K1A	366	Q99755
GELSDGRAGPSEARM	LRIT1	416	Q9P2V4
PTVEQQGEMARSGGR	ALDH18A1	361	P54886
PEFVRDVMGSSAGAG	PRKRIP1	61	Q9H875
MAGGAGPRSESDLED	KLC2	511	Q9H0B6
MEGGLADGEPDRTSL	OSBPL8	1	Q9BZF1
MDRPFSAEAGTGGLE	NPAS4	646	Q8IUM7
MVARSTDSLDGPGEG	ARHGAP33	1	O14559
GAGPREERMVTGAGV	BOD1L1	1746	Q8NFC6
AEGEMGSARRPEKRG	APC2	1741	O95996
GQEERAGVMSTGPIR	HLA-DOB	161	P13765
MGVEIETISPGDGRT	FKBP1B	1	P68106
PRRVTAGEGMGSLRS	CDHR3	821	Q6ZTQ4
ERDFSISGGELGPTM	ACSBG1	686	Q96GR2
RGAGEGSEREPRMPV	C20orf144	81	Q9BQM9
PEVMLSGERLTSGFG	ITGA7	351	Q13683
PMDGRGGRDSRAMET	CSTF2T	406	Q9H0L4
MTPSEGARAGTGREL	ELP5	1	Q8TE02
RRDLGVGTSMEGASP	FANCE	141	Q9HB96
TLKRGGGPRSSEEMA	EIF2B2	21	P49770
GGPRSSEEMARETLG	EIF2B2	26	P49770
SRRLQMEGEGGGETP	EFHD2	11	Q96C19
EGALTMPREGSTESE	HDAC5	566	Q9UQL6
MAESTRDGLGPGLLS	GLIS1	446	Q8NBF1
RTGTFGVLMDASPRE	CELSR3	2516	Q9NYQ7
GGPGMVTDAERSIVS	GTF2IRD2	191	Q86UP8
GGPGMVTDAERSIVS	GTF2IRD2B	191	Q6EKJ0
DSPGGRGISDSRMAD	FBXO30	436	Q8TB52
MVRGELVDESGGSPL	PRDM13	51	Q9H4Q3
GEGMFRRPSEGQSLI	RUBCN	461	Q92622
GERFATMVRPVAESG	S1PR4	141	O95977
MEESPLSRAPSRGGV	CALCOCO1	1	Q9P1Z2
GDRVLAMGEDGSPTF	IHH	226	Q14623
GPPSGRVERAMSEVT	LSR	421	Q86X29
GQGRVRTGMARSEDP	NUTM2F	561	A1L443
GQGRVRTGMARSEDP	NUTM2G	546	Q5VZR2
VSRDDATGSPRPGLM	FUT5	36	Q11128
PESRTARGGSQMDVL	UTRN	1406	P46939
GLASSEEAEGRMRGP	RBM6	1076	P78332
EEAEGRMRGPSVGAS	RBM6	1081	P78332
GTEDSLMGRTRETGT	RAB11FIP1	666	Q6WKZ4
SEMQLEDGGRRRPSG	RIMBP2	766	O15034
MAAGGSDPRAGDVEE	POLR2D	1	O15514
PGSLGLEESGSRRMQ	PPP1R8	241	Q12972
EVFEASEGARPGSRM	PSD	366	A5PKW4
SPQMSELRREGRGGG	TMEM200B	91	Q69YZ2
RGAEGSMRGARREPE	TMEM200C	426	A6NKL6
MAGSDVDSEGPARRG	TMEM229A	1	B2RXF0
SMTLEIREGRGCGPE	SDHA	346	P31040
GGGRSREGTMELRTT	LTB4R2	316	Q9NPC1
MQVEAGGTSPAGERR	SORCS3	101	Q9UPU3
SQDSGAPGEAMERLG	UPF3A	401	Q9H1J1
MAVSERRGLGRGSPA	GPR108	1	Q9NPR9
SARPAAGVGDTGMED	SIGLEC8	391	Q9NYZ4
PMSDRSGDGISREID	SIN3B	376	O75182
ELDMGAAERSREPGS	SHOX2	96	O60902
MEGPLSVFGDRSTGE	TCP1	1	P17987
ERDAEQSGSPRTGMG	NFIC	186	P08651
EGTRRRAAEAPSMGT	SLC12A4	106	Q9UP95
ESGATGRRVMDSPER	SPICE1	466	Q8N0Z3
AEVPEESSRMAGSGA	ASPRV1	76	Q53RT3
MEEFVGLREGSSGNP	CLCNKB	1	P51801
ADSGVTIDTTMRGGR	THBS4	906	P35443
GQRDTEGSKMSPRAG	ZNF750	391	Q32MQ0
EAGEAPLGEMRASEG	ZNF516	96	Q92618
PAAMETGKDGARRGT	STK35	131	Q8TDR2
RGSALGMSQRTVPGE	USP43	1081	Q70EL4
SRGRASMADGDLEPE	TTBK1	816	Q5TCY1
RREDMTEPGGAGEPA	TDRKH	221	Q9Y2W6
GPALGEVGEAMRELS	SH3GL2	111	Q99962
MAAVDSDVESLPRGG	TUT1	1	Q9H6E5
GGEPFMVEREISTGA	ZNF514	56	Q96K75
GSPGSREMGLLTFRD	ZNF679	6	Q8IYX0
GRTRGDSVTQMEGPV	TRAV9-2	16	A0A087WT02
PRSEMNSSVGDLGVG	nan	31	Q7L0L9
TMGRPRALGGQEESG	ZNF775	56	Q96BV0
MGRLEDGSPRTGQIF	GH1	151	P01241
VDLEPGTMDSVRSGA	TUBB3	66	Q13509
GAVARPTGGIVDMAS	VPS13C	3561	Q709C8
DESEDGMRTRPGDGS	USB1	16	Q9BQ65
RADGTMRLGEPTSNE	SMO	296	Q99835
VTGEQLGMSSPRGGR	PLCH1	1051	Q4KWH8
QEEGPGIDGMTTSER	SYMPK	21	Q92797
RGPGQSRMEDTRDKG	YLPM1	1021	P49750
SRITGGMEAEVGEFP	PRSS55	66	Q6UWB4
DVISDGRGSRPSPAM	ZNF469	2626	Q96JG9
TGPEGGLTRMERKAA	ZNF252P-AS1	176	Q0IIN9
GPMGTELGDFLREVS	TNK1	156	Q13470
SPTSDLEMRGGRGRG	ZNF608	421	Q9ULD9
RRAGAESPTMSVDGR	ZNF217	401	O75362
EPTSEARIGMGATLD	UBAC2	226	Q8NBM4
AESEGAETPRMRSEG	VSIG10L	346	Q86VR7
PETDDSRVGGIMRGE	TOGARAM1	31	Q9Y4F4
SMRGEAPGAETPSLR	TMUB1	61	Q9BVT8
DDGGQRRESPTMTEF	AGPAT5	236	Q9NUQ2
MMATRRTGLSEGDGD	ARHGAP21	1	Q5T5U3
VMDSGEEVPGTRVTG	TG	1191	P01266
GGGERPSGQDLRATM	TUB	171	P50607
EMSTRDRFQLTGDPG	SIGLEC11	96	Q96RL6
REGGEGARRSDTMAG	TERF2	31	Q15554
LERTPGDGLATMVAG	THAP4	171	Q8WY91
GTRGIGMRPEESDSE	PPIP5K1	26	Q6PFW1
RERADGTGPTKGDME	WFS1	71	O76024
SRSLEGRPEGAGVAM	ZBTB8B	301	Q8NAP8
SGMREALSQEAGGPE	KLHL42	36	Q9P2K6
SRMDKTAGSVRGGDE	NFKB2	231	Q00653