Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-25 ERVK-24

2.25e-11371739GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-25 ERVK-24

2.93e-11381739GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.71e-06111734GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

5.09e-06141734GO:0003964
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 POP1 ERVK-8

1.60e-05371735GO:0016891
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 ERVK-8

2.90e-05211734GO:0035613
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 POP1 ERVK-8

4.74e-05461735GO:0016893
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5A KDM5C JMJD1C KDM7A

9.47e-05281734GO:0141052
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 CD46 ERVK-7 ERVK-21 ERVK-9 ERVK-10 OVCH1 HP LPA ERVK-8 ERVK-19 ERVK-25 ERVK-24

9.97e-0543017313GO:0004175
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5A KDM5C JMJD1C KDM7A

1.43e-04311734GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5A KDM5C JMJD1C KDM7A

1.62e-04321734GO:0140457
GeneOntologyMolecularFunctionenzyme regulator activity

NOLC1 MYCBP2 KDM5A BCAS3 STXBP5 DBF4B LRRK2 WFDC6 RASGEF1A COX17 DAXX SPINK14 PPP1R26 PTN PSME4 CCNB3 ARHGAP31 LPA SBF2 PARVA FNIP1 SMO SUZ12 GREM1 RAPGEF2 IL6ST

2.25e-04141817326GO:0030234
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

3.19e-04381734GO:0034061
GeneOntologyMolecularFunctionhistone binding

KDM5A BCAS3 DAXX KMT2E SCML2 PSME4 KDM7A SUZ12 UHRF2

5.21e-042651739GO:0042393
GeneOntologyMolecularFunctiondemethylase activity

KDM5A KDM5C JMJD1C KDM7A

5.64e-04441734GO:0032451
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 POP1 ERVK-8

6.19e-04791735GO:0004521
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 ZFAND2A MYCBP2 KDM5A DBF4B ASAH2 ZGRF1 KDM5C ERVK-7 ERVK-21 ERVK-9 ERVK-10 ADH7 ERVK-8 ERVK-5 ERVK-19 KDM7A ERVK-24

7.48e-0489117318GO:0008270
GeneOntologyMolecularFunctionhistone modifying activity

KDM5A KDM5C JADE1 KMT2E JMJD1C KDM7A SUZ12 PRDM16

8.85e-042291738GO:0140993
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5A KDM5C

1.09e-0361732GO:0034647
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 XRN2 ERVK-7 ERVK-10 POP1 ERVK-8

1.20e-031361736GO:0004540
GeneOntologyMolecularFunctiontranscription coregulator activity

ZNF410 ABL1 RIPK3 KDM5A ZNF366 DAXX JADE1 BCOR KMT2E JMJD1C KDM7A PRDM16 HCFC1

1.26e-0356217313GO:0003712
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 ZFAND2A ABL1 MYCBP2 KDM5A DBF4B ASAH2 ZGRF1 ACO2 KDM5C COX17 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ADH7 ERVK-8 ERVK-5 ERVK-19 KDM7A ERVK-24

1.50e-03118917321GO:0046914
GeneOntologyMolecularFunctiondioxygenase activity

KDM5A KDM5C JMJD1C PTGS2 KDM7A

1.63e-03981735GO:0051213
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 CD46 ERVK-7 ERVK-21 ERVK-9 ERVK-10 OVCH1 HP LPA ERVK-8 OTUD4 ERVK-19 ERVK-25 ERVK-24

1.71e-0365417314GO:0008233
GeneOntologyMolecularFunctionprotein kinase regulator activity

NOLC1 DBF4B DAXX CCNB3 PARVA SMO GREM1 IL6ST

1.93e-032591738GO:0019887
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-6 RPS2 PCLO ERVK-7 ERVK-21 ERVK-9 ERVK-10 MRPS30 MEGF9 ERVK-8 PKP1 ERVK-5 COL14A1 ERVK-19 ERVK-25 ERVK-24 RPL6

1.93e-0389117317GO:0005198
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5A KDM5C

2.02e-0381732GO:0032453
GeneOntologyMolecularFunctionMHC class I protein complex binding

KLRC4 CD8A

2.02e-0381732GO:0023024
GeneOntologyMolecularFunctionmolecular function inhibitor activity

NOLC1 KDM5A LRRK2 WFDC6 DAXX SPINK14 PPP1R26 ADH7 PTN LPA PARVA FNIP1 SMO

2.12e-0359617313GO:0140678
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 ABL1 OAS2 ERVK-7 ERVK-10 ERVK-8

2.12e-031521736GO:0016779
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NOLC1 ZNF410 ABL1 RIPK3 GAS2L3 TCOF1 KDM5A ZNF366 LRRK2 DAXX JADE1 BCOR KMT2E JMJD1C IFNAR2 CUL5 COL14A1 KDM7A PRDM16 HCFC1

2.58e-03116017320GO:0030674
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8

3.01e-06131704GO:0015074
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-6 ATAD5 DBF4B TRAIP ERVK-7 ERVK-10 WIZ ERVK-8 CDT1

1.74e-051781709GO:0006261
GeneOntologyBiologicalProcessviral process

ERVK-6 OAS2 CD46 ERVK-7 ERVK-21 ERVK-9 ERVK-10 EDEM2 ERVK-8 ERVK-5 CD74 ERVK-19 ERVK-24 HCFC1

3.19e-0546417014GO:0016032
DomainPHD

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

3.77e-06751617PF00628
DomainZnf_PHD-finger

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

5.35e-06791617IPR019787
DomainPHD

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

1.18e-05891617SM00249
DomainZnf_PHD

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

1.37e-05911617IPR001965
DomainZF_PHD_2

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

1.82e-05951617PS50016
DomainZF_PHD_1

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

1.94e-05961617PS01359
DomainZnf_FYVE_PHD

KDM5A KDM5C PCLO JADE1 KMT2E KDM7A UHRF2 PHF21B

4.14e-051471618IPR011011
DomainJmjC

KDM5A KDM5C JMJD1C KDM7A

4.94e-05241614PF02373
DomainZnf_C2H2-like

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 ZNF750 WIZ ZNF592 ZNF616 SUZ12 ZKSCAN4 PRDM16 ZNF114

5.77e-0579616119IPR015880
DomainZnF_C2H2

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 ZNF750 WIZ ZNF592 ZNF616 SUZ12 ZKSCAN4 PRDM16 ZNF114

7.03e-0580816119SM00355
DomainZINC_FINGER_C2H2_2

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 WIZ ZNF592 ZNF616 SUZ12 ZKSCAN4 PRDM16 ZNF114

1.29e-0477516118PS50157
DomainZINC_FINGER_C2H2_1

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 WIZ ZNF592 ZNF616 SUZ12 ZKSCAN4 PRDM16 ZNF114

1.33e-0477716118PS00028
DomainJMJC

KDM5A KDM5C JMJD1C KDM7A

1.58e-04321614PS51184
DomainJmjC_dom

KDM5A KDM5C JMJD1C KDM7A

1.58e-04321614IPR003347
DomainJmjC

KDM5A KDM5C JMJD1C KDM7A

1.79e-04331614SM00558
DomainZnf_C2H2

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 ZNF750 WIZ ZNF592 ZNF616 ZKSCAN4 PRDM16 ZNF114

2.06e-0480516118IPR007087
DomainZinc_finger_PHD-type_CS

KDM5A KDM5C JADE1 KMT2E KDM7A

2.43e-04651615IPR019786
DomainLys_sp_deMease-like_dom

KDM5A KDM5C

4.38e-0441612IPR013637
DomainPLU-1

KDM5A KDM5C

4.38e-0441612PF08429
Domainzf-C5HC2

KDM5A KDM5C

7.26e-0451612PF02928
DomainZnf_C5HC2

KDM5A KDM5C

7.26e-0451612IPR004198
DomainZnf_C2H2/integrase_DNA-bd

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZNF831 ZBTB42 ZNF518A PRDM1 ZNF616 ZKSCAN4 PRDM16 ZNF114

9.99e-0469416115IPR013087
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KDM5A RPS2 KDM5C JADE1 KANSL2 KDM7A SUZ12 PRDM16 HCFC1

6.16e-061751059MM14941
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-5 ERVK-19 ERVK-25 ERVK-24

5.64e-11941771021542922
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

6.48e-104177410469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-10 ERVK-5 ERVK-19

6.48e-10417747983737
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

2.48e-0912177514557543
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-21 ERVK-19

3.23e-095177412629516
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-25 ERVK-24

2.62e-0818177518664271
Pubmed

Human transcription factor protein interaction networks.

NOLC1 XRN2 ATXN7L2 KDM5A ATAD5 SOBP MARS1 BICRA ACO2 C15orf39 ZNF217 BCOR JMJD1C PRDM1 FAT1 KANSL2 WIZ GTF3C2 ZNF592 MKI67 OTUD4 ZKSCAN4 EN1 PRDM16 HCFC1

7.66e-0814291772535140242
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NOLC1 XRN2 TCOF1 MYCBP2 KDM5A KDM5C DAXX ZNF217 BCOR SCML2 KANSL2 PTPRC ZNF592 POP1 MKI67 OTUD4 CDT1 SUZ12

1.01e-077741771815302935
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

KDM5A ATAD5 ZNF174 DAXX BCOR JMJD1C FSIP2 SCML2 WIZ GTF3C2 ZNF592 MKI67 SUZ12 ZKSCAN4 UHRF2 HCFC1

1.03e-076081771636089195
Pubmed

S100B binding to RAGE in microglia stimulates COX-2 expression.

MOK PTGS2 AGER

1.30e-073177317023559
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF438 ZNF410 KDM5A KDM5C E2F2 JADE1 PKHD1L1 PRDM1 ZNF750 WIZ ZNF592 ZNF616 TSC22D4 ZKSCAN4 UHRF2 PRDM16 PLXNA2

9.29e-078081771720412781
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

BICRA PCLO C15orf39 ZNF217 BCOR JMJD1C ZNF518A WDR3 WIZ SUZ12 PRDM16 RPL6

1.06e-063981771235016035
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7 ERVK-5

1.29e-065177311401426
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MYCBP2 KDM5A ZGRF1 C15orf39 ZNF217 BCOR JMJD1C WIZ GTF3C2 ZNF592 PLEKHA2 ZKSCAN4

1.76e-064181771234709266
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

2.56e-066177315063128
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM5A KDM5C KMT2E KDM7A

3.63e-0621177427626377
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABL1 SEMA7A MYCBP2 BCAS3 BICRA C15orf39 JADE1 TTC3 ZBTB42 BAHD1 PPP1R26 FAT1 WIZ PSME4 ZNF592 NBEAL2 SBF2 PRDM16 HCFC1

4.05e-0611051771935748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

NOLC1 ATXN7L2 TCOF1 VEZT KDM5A ATAD5 BICRA KDM5C E2F2 BCOR ZNF518A SLC35G1 FAT1 WIZ CCNB3 ZNF592 SUZ12 RAPGEF2 PRDM16

4.67e-0611161771931753913
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

ZNF217 BCOR JMJD1C ZNF592 ARHGAP31 SCN9A MKI67 RPL6

5.01e-06184177832908313
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5A KDM5C KMT2E JMJD1C KDM7A

5.13e-0649177534368113
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NOLC1 XRN2 ATXN7L2 TCOF1 KDM5A ATAD5 RPS2 HEATR1 BCOR JMJD1C WDR3 SCML2 KANSL2 WIZ GTF3C2 POP1 MKI67 SUZ12 HCFC1 RPL6

1.07e-0512941772030804502
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

NOLC1 XRN2 TCOF1 RPS2 MARS1 DAXX ZNF217 HEATR1 CMSS1 JMJD1C PTGS2 WDR3 ZNF592 POP1 MKI67 HCFC1 RPL6

1.34e-059891771736424410
Pubmed

Interaction network of human early embryonic transcription factors.

KDM5A SOBP BICRA C15orf39 ZNF217 BCOR WIZ MKI67 UHRF2 PRDM16

1.40e-053511771038297188
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-21 ERVK-19

1.51e-0510177312970426
Pubmed

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb.

PRDM1 SMO GREM1

1.51e-0510177318832070
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

XRN2 LRCH2 TCOF1 MYCBP2 RPS2 DAXX WDR3 GTF3C2 ZNF592 POP1 MKI67

1.75e-054401771134244565
Pubmed

Strains matter: Success of murine in vitro spermatogenesis is dependent on genetic background.

PRDM1 MKI67 CD74

2.08e-0511177331421080
Pubmed

BCOR-CCNB3 fusion-positive clear cell sarcoma of the kidney.

BCOR CCNB3

2.58e-052177231876361
Pubmed

RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice.

RIPK3 DAXX

2.58e-052177237553782
Pubmed

Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma.

PTGS2 MKI67

2.58e-052177226423666
Pubmed

Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.

SEMA7A PTGS2

2.58e-052177227065336
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

2.58e-05217729060628
Pubmed

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death.

RIPK3 DAXX

2.58e-052177223260419
Pubmed

Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues.

BCOR CCNB3

2.58e-052177228817404
Pubmed

BCOR-CCNB3 fusions are frequent in undifferentiated sarcomas of male children.

BCOR CCNB3

2.58e-052177225360585
Pubmed

Diabetes, leukoencephalopathy and rage.

MOK AGER

2.58e-052177216815028
Pubmed

CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome.

PTPRC CD8A

2.58e-052177225804232
Pubmed

Reduced expression of Blimp-1 in memory B cells in patients with HIV-1 infection suggests distinct roles of this molecule for B and T cell regulation.

PRDM1 MKI67

2.58e-052177225265234
Pubmed

RAGE ligation affects T cell activation and controls T cell differentiation.

MOK AGER

2.58e-052177218768885
Pubmed

RAGE interacts with the necroptotic protein RIPK3 and mediates transfusion-induced danger signal release.

RIPK3 AGER

2.58e-052177232633835
Pubmed

Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products.

PTGS2 AGER

2.58e-052177212837757
Pubmed

A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion.

BCOR CCNB3

2.58e-052177222387997
Pubmed

Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential.

PTPRC CD8A

2.58e-052177212091326
Pubmed

Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice.

MOK AGER

2.58e-052177214693711
Pubmed

Differential antigen processing by dendritic cell subsets in vivo.

PTPRC CD8A

2.58e-052177217204652
Pubmed

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

PRDM1 PTPRC

2.58e-052177228363897
Pubmed

Neutrophil-derived advanced glycation end products-Nε-(carboxymethyl) lysine promotes RIP3-mediated myocardial necroptosis via RAGE and exacerbates myocardial ischemia/reperfusion injury.

RIPK3 AGER

2.58e-052177231665609
Pubmed

Regulation of osteoclast function and bone mass by RAGE.

MOK AGER

2.58e-052177216606672
Pubmed

BCOR-CCNB3 (Ewing-like) sarcoma: a clinicopathologic analysis of 10 cases, in comparison with conventional Ewing sarcoma.

BCOR CCNB3

2.58e-052177224805859
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

2.58e-05217729460924
Pubmed

An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study.

BCOR CCNB3

2.58e-052177230064235
Pubmed

Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3.

BCOR CCNB3

2.58e-052177228877060
Pubmed

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.

PRDM1 MKI67 CD74

3.57e-0513177332493987
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

NOLC1 XRN2 RPS2 HEATR1 CMSS1 WDR3 GTF3C2 HP POP1 MKI67 RPL6

4.08e-054831771136912080
Pubmed

Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.

PRDM1 MKI67 GREM1

4.53e-0514177318039967
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NOLC1 XRN2 MYCBP2 MARS1 BICRA ZNF174 NARS1 C15orf39 ZNF217 CMSS1 BCOR JMJD1C WIZ MKI67 ZKSCAN4 UHRF2 HCFC1

5.28e-0511031771734189442
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

NOLC1 XRN2 TCOF1 RPS2 HEATR1 WDR3 CFAP20 RPL6

5.85e-05259177830404004
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

XRN2 ATXN7L2 JMJD1C WDR3 WIZ HCFC1

6.69e-05134177625452129
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

NOLC1 TCOF1 JMJD1C CUL5 WDR3 SCML2 WIZ MKI67 HCFC1

6.81e-05341177932971831
Pubmed

Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.

PTGS2 MKI67 IL6ST

6.91e-0516177322100262
Pubmed

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.

RIPK3 PTPRC MKI67

6.91e-0516177330185824
Pubmed

Differential Expression of RAGE, EGFR and Ki-67 in Primary Tumors and Lymph Node Deposits of Breast Carcinoma.

AGER MKI67

7.70e-053177230139236
Pubmed

Expression of COX-2, p16, and Ki67 in the range from normal breast tissue to breast cancer.

PTGS2 MKI67

7.70e-053177233147051
Pubmed

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

KDM5A KDM5C

7.70e-053177217320161
Pubmed

Is the immunohistochemical expression of proliferation (Ki-67) and apoptosis (Bcl-2) markers and cyclooxigenase-2 (COX-2) related to carcinogenesis in postmenopausal endometrial polyps?

PTGS2 MKI67

7.70e-053177223301386
Pubmed

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

KDM5A KDM5C

7.70e-053177238230606
Pubmed

Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.

PTGS2 GREM1

7.70e-053177238524634
Pubmed

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.

DSCAM EN1

7.70e-053177238302444
Pubmed

Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.

PTPRC CD8A

7.70e-05317721834739
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

7.70e-053177210516026
Pubmed

MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.

KMT2E HCFC1

7.70e-053177233050986
Pubmed

A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).

BCOR CCNB3

7.70e-053177236791667
Pubmed

KRAS drives immune evasion in a genetic model of pancreatic cancer.

PTPRC CD8A

7.70e-053177233674596
Pubmed

Expression of PCNA, Ki-67 and COX-2 in breast cancer based on DCE-MRI image information.

PTGS2 MKI67

7.70e-053177231289003
Pubmed

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

KDM5A KDM5C

7.70e-053177226645689
Pubmed

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

E2F2 ADGRE2

7.70e-053177229072692
Pubmed

Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy.

PDYN LGI1

7.70e-053177218355961
Pubmed

Aromatase and cyclooxygenase-2 expression in endometrial polyps during the menstrual cycle.

PTGS2 MKI67

7.70e-053177216723309
Pubmed

Phosphorylation of proteins by inositol pyrophosphates.

NOLC1 TCOF1

7.70e-053177215604408
Pubmed

CUMULUS CELL GENES AS POTENTIAL BIOMARKERS OF OOCYTE AND EMBRYO DEVELOPMENTAL COMPETENCE.

PTGS2 GREM1

7.70e-053177229537212
Pubmed

Is SIRT2 required for necroptosis?

RIPK3 EN1

7.70e-053177224572428
Pubmed

Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily.

MOK AGER

7.70e-053177215599399
Pubmed

RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.

MOK AGER

7.70e-053177219176597
Pubmed

Implication of the RAGE-EN-RAGE axis in endometriosis.

PTGS2 AGER

7.70e-053177220537326
Pubmed

KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas.

KDM5A KDM5C

7.70e-053177237880235
Pubmed

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

MOK AGER

7.70e-053177218367618
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

7.70e-05317729971820
Pubmed

Co-Expression of p16, Ki67 and COX-2 Is Associated with Basal Phenotype in High-Grade Ductal Carcinoma In Situ of the Breast.

PTGS2 MKI67

7.70e-053177225711229
Pubmed

JADE1 is dispensable for the brain development in mice.

JADE1 MKI67

7.70e-053177238171233
Pubmed

Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway.

KDM5A SUZ12

7.70e-053177232918895
Pubmed

The expression of p53, ki67 and COX-2 in erosive-type oral lichen planus.

PTGS2 MKI67

7.70e-053177238063088
Pubmed

Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin.

PTN SUZ12

7.70e-053177219749796
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

NOLC1 WIZ MKI67 UHRF2 HCFC1

8.05e-0586177537253089
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

KDM5A ATAD5 MARS1 ATP5MF DAXX ZNF217 HEATR1 CMSS1 BCOR WDR3 SCML2 WIZ GTF3C2 ZNF592 CFAP20 CRACDL GORAB POP1 OTUD4 SUZ12

8.27e-0514971772031527615
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NOLC1 KDM5C JADE1 BCOR BAHD1 PSME4 GTF3C2 ZNF592 ARHGAP31 NBEAL2 KDM7A

9.18e-055291771114621295
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

NOLC1 ATAD5 RPS2 BICRA DAXX HEATR1 SCML2 GTF3C2 ZNF592 MKI67 SUZ12

9.81e-055331771130554943
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

XRN2 DSCAM TCOF1 MYCBP2 KDM5A NARS1 ATP5MF TTC3 WDR3 KANSL2 WIZ MEGF9 ZNF592 CD74 RAPGEF2 PIP4P2 MTUS2 LGI1

1.06e-0412851771835914814
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

NOLC1 XRN2 TCOF1 JMJD1C MKI67 HCFC1

1.16e-04148177632538781
Pubmed

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.

MKI67 SMO PRDM16

1.18e-0419177325848030
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

KDM5A BCAS3 KDM5C HEATR1 CMSS1 JMJD1C MRPS30 KANSL2 WIZ GTF3C2 CFAP20 POP1 PKP1 HCFC1

1.36e-048571771425609649
InteractionCBX3 interactions

ATXN7L2 TCOF1 ATAD5 KDM5C LRRK2 DAXX ZNF217 HEATR1 BCOR BAHD1 ZNF518A WDR3 ZNF750 SCML2 WIZ MKI67 SUZ12 ZKSCAN4 UHRF2 PRDM16

4.72e-0764616820int:CBX3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF438 ZNF410 ZNF627 ZNF366 ZNF174 ZNF621 ZNF217 ZBTB42 ZNF518A PRDM1 WIZ ZNF592 ZNF616 SUZ12 ZKSCAN4 PRDM16 ZNF114

5.92e-077181031728
GeneFamilyPHD finger proteins

KDM5A KDM5C JADE1 KMT2E KDM7A UHRF2 PHF21B

8.04e-0790103788
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5A KDM5C JMJD1C KDM7A

9.67e-06241034485
CoexpressionGSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TCONV_UP

ABL1 DSCAM MYCBP2 LRRK2 NUBP1 OAS2 DAXX KANSL2 PTPRC

4.80e-061991649M8964
CoexpressionGSE13411_PLASMA_CELL_VS_MEMORY_BCELL_UP

E2F2 TG PRDM1 IFNAR2 PPP1R26 MKI67 CDT1 GSG1

3.68e-051981648M3253
CoexpressionGSE40273_XBP1_KO_VS_WT_TREG_DN

SEMA7A MYCBP2 ZNF217 JMJD1C NBEAL2 SBF2 MKI67 PKP1

3.81e-051991648M9124
CoexpressionFISCHER_DREAM_TARGETS

NOLC1 GAS2L3 TCOF1 ATAD5 MARS1 DBF4B ZGRF1 TRAIP E2F2 HEATR1 JADE1 CMSS1 ZNF518A GTF3C2 MKI67 CDT1 SUZ12 HCFC1

3.88e-0596916418M149
CoexpressionGSE5503_MLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_UP

TCOF1 MYCBP2 TTC3 CFAP20 NBEAL2 SMO RAPGEF2 MTUS2

3.95e-052001648M293
CoexpressionGSE27786_BCELL_VS_MONO_MAC_UP

MYCBP2 KDM5A MARS1 ACO2 ATP5MF COX17 BAHD1 POP1

3.95e-052001648M4817
CoexpressionGSE46606_IRF4_KO_VS_WT_UNSTIM_BCELL_UP

GAS2L3 JMJD1C CDT1 ZKSCAN4 UHRF2 RPL6 PLXNA2 FAM110B

3.95e-052001648M9860
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAS2L3 RASGEF1A CADM2 MEGF9 SCN9A FAM181A TSC22D4 LGI1

3.95e-07180166838490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCelldroplet-Spleen-nan-18m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XRN2 MYCBP2 LRRK2 JMJD1C PTPRC PLEKHA2 CD74 RPL6

4.48e-07183166828cbf909424f3be4491d49832f0aca0386560814
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XRN2 MYCBP2 LRRK2 JMJD1C PTPRC PLEKHA2 CD74 RPL6

4.48e-0718316683fa608aa6b119869ec3280dc388dfee57160e63a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATXN7L2 ZGRF1 RASGEF1A AK7 SLC35G1 CFAP20 POP1 CDT1

4.48e-071831668ba7753e9fe2a6a87c5264f299ac97da2ddbda178
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABL1 SEMA7A TCOF1 ZNF366 RAB33A CD74 GNG7 MTUS2

5.49e-071881668d5ce3ffe783c322b4765b790e861727e46bc34b3
ToppCell367C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ABL1 SEMA7A SOBP JMJD1C RAB33A CD8A NBEAL2 CD74

7.24e-071951668fca958f73de450ef813444d3dc590353f1c55326
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZNF410 BCAS3 TG PPP1R26 RAB33A SCML2 POP1

3.16e-0616716677e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue|TCGA-Stomach / Sample_Type by Project: Shred V9

ASAH2 CADM2 ADH7 PTN GNG7 MTUS2 LGI1

3.70e-0617116670f8d038858a4618b4348becc26a618d43b10d9d6
ToppCellTCGA-Stomach-Solid_Tissue_Normal|TCGA-Stomach / Sample_Type by Project: Shred V9

ASAH2 CADM2 ADH7 PTN GNG7 MTUS2 LGI1

3.70e-061711667791d37fe94ff2820fb409bbd38b31799df700ba1
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue|TCGA-Stomach / Sample_Type by Project: Shred V9

ASAH2 CADM2 ADH7 PTN GNG7 MTUS2 LGI1

3.70e-0617116670bf36930bd7fc63691f48a15db93deb1dd937c10
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

ZNF410 BCAS3 TG PPP1R26 RAB33A SCML2 POP1

3.84e-0617216679dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GAS2L3 ATAD5 TRAIP CRACDL MKI67 CDT1 ZKSCAN4

4.31e-0617516670b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SEMA7A ZNF366 LRRK2 PRDM1 PTPRC CLEC17A CD74

5.00e-0617916679fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 ZGRF1 TRAIP PCLO SCML2 MKI67 CDT1

5.99e-06184166716aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GAS2L3 ZGRF1 TRAIP PCLO SCML2 MKI67 CDT1

6.20e-061851667b4af9ae4c358b48357cb135b740266e1652d886a
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PCLO LRRK2 JMJD1C PTGS2 MEGF9 KDM7A PRDM16

6.42e-06186166723b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-Plasma_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CMSS1 PKHD1L1 IFNAR2 EDEM2 MKI67 CDT1 GNG7

8.46e-061941667297286c57d7ee6338d9cf77b27eb2809378ce15d
ToppCellnormal_Lung-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

SEMA7A ZNF366 RPS2 RAB33A CD74 SMO GNG7

8.46e-061941667d21461682fa755f588afe073abb6a777f339c4cc
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

MYCBP2 RPS2 PTGS2 PRDM1 MKI67 CD74 CDT1

8.74e-0619516677fb5c0911ff09580515d1a1827d7249d6242630c
ToppCell(0)_NK_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CCDC28B ATAD5 ZGRF1 TRAIP E2F2 MKI67 CDT1

9.66e-0619816675ebb4965b723302152b42bfaf48bb77a57dd02c5
ToppCellproximal-3-Epithelial-Proliferating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATAD5 TRAIP E2F2 ADH7 MKI67 PKP1 CDT1

9.98e-0619916672263bb73d9c5693b44d91d2548305efc1b6e4079
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

ZGRF1 WIZ GTF3C2 NBEAL2 SCN9A ZNF616 CAPS2

9.98e-061991667fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCellproximal-Epithelial-Proliferating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATAD5 TRAIP E2F2 ADH7 MKI67 PKP1 CDT1

9.98e-061991667521ff4ae3437c8ba477a0a42b9da195af976c3ff
ToppCellproximal-Epithelial-Proliferating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATAD5 TRAIP E2F2 ADH7 MKI67 PKP1 CDT1

9.98e-061991667e8549b2c4152cb23548351d9cee27c3805892cd8
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

GAS2L3 ATAD5 ZGRF1 E2F2 CADM2 MKI67 CDT1

1.03e-0520016674cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCell3'_v3-Lung-Lymphocytic_NK-Cycling_NK|Lung / Manually curated celltypes from each tissue

CCDC28B ATAD5 ZGRF1 TRAIP E2F2 MKI67 CDT1

1.03e-052001667381bafdde6492f020ae93ab8fffa6215c631c570
ToppCellTracheal-NucSeq-Immune_Myeloid-Dendritic_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA7A GAS2L3 ZNF366 ADGRE2 PTPRC ARHGAP31 CD74

1.03e-05200166741a206350eff2a196ccc1a36a9636a87c74f6962
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

STXBP5 LRRK2 MEGF9 HP NBEAL2 KDM7A PIP4P2

1.03e-052001667808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Proliferative_AT1_Progenitor|E16.5-samps / Age Group, Lineage, Cell class and subclass

BCOR PPP1R26 CRACDL TXNDC2 MTUS2 LGI1

1.07e-051331666b0d3ac5abd9ebd490db46a3ef2e4ae88c4bf4e34
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|356C / Donor, Lineage, Cell class and subclass (all cells)

RASGEF1A KLRC4 PRDM1 PTPRC CD8A SBF2

1.62e-051431666e8fc6540a48086f58bc3f42dabe392ef46715b9e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GAS2L3 PDYN PRDM1 FAT1 GREM1 CAPS2

1.62e-05143166624fd24846fbef049af669a57d42fcc18928d2b27
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MOK NOLC1 ZNF366 LRRK2 PTGS2 MREG

2.05e-051491666a85a051e0d82430160967e72fa04b55f43e84513
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

ATXN7L2 CCDC168 KLRC4 JMJD1C ZNF518A WDR3

2.05e-051491666768877bade04ca0321593b8470b5011ad8270431
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MOK NOLC1 ZNF366 LRRK2 PTGS2 MREG

2.12e-0515016667a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ATXN7L2 ARMC12 CCDC168 SLC35G1 CD8A CFAP157

2.65e-051561666c11ca6b1b5029c15aab91273cece70a487287839
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|Lung / Manually curated celltypes from each tissue

ZNF831 KLRC4 PRDM1 PTPRC CD8A PRDM16

2.75e-051571666af6eb2214340847bbab7cb209ea27cdc83b62a27
ToppCell10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)|bone_marrow / Manually curated celltypes from each tissue

ATAD5 E2F2 CCDC168 MKI67 CDT1 MTUS2

2.75e-051571666d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCellfacs-Trachea-nan-18m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC28B ZNF831 PRDM1 PTPRC CD74 CDT1

3.06e-0516016665c9281706009558c8361bfa76169f43ffc0f7947
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PDYN TRAIP LRRK2 C6orf163 ZNF831 CRACDL

3.16e-051611666ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell368C-Myeloid-Dendritic-cDC1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SEMA7A TCOF1 ZNF366 RAB33A CD8A GNG7

3.16e-0516116661011094c54381d52566e24c92f89f2efc2aa3eea
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SEMA7A ZNF366 SCN9A CD74 GNG7 MTUS2

3.28e-05162166686a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCDC28B KMT2E ZNF831 PRDM1 CD74 CDT1

3.51e-0516416664274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCDC28B KMT2E ZNF831 PRDM1 CD74 CDT1

3.51e-051641666d62143450f59097ad4b34603a6257f897a769ead
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF410 BCAS3 TG PPP1R26 SCML2 POP1

3.63e-05165166635a6de30438de364ccca948fc932da541a69ef89
ToppCellCV-Mild-3|Mild / Virus stimulation, Condition and Cluster

TCOF1 DBF4B KANSL2 CFAP20 AGER CDT1

3.75e-0516616665599f90fc0e15a3670b03187085eba91228390a2
ToppCell368C-Lymphocytic-NK_cells-NK_cell_C|368C / Donor, Lineage, Cell class and subclass (all cells)

RBM45 ATAD5 BICRA ZNF174 ZGRF1 CMSS1

4.01e-0516816660372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

KLRC4 PRDM1 PTPRC CD8A MKI67 CDT1

4.43e-051711666dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCellICU-SEP-Lymphocyte-B-B_intermediate|ICU-SEP / Disease, Lineage and Cell Type

SEMA7A PCLO PKHD1L1 PTCHD1 CD74 GNG7

4.43e-0517116662e44bf6f3d90193e7cadcac48bb852bd632a81bc
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSCAM ZNF366 LRRK2 MREG PLEKHA2 CD74

4.58e-051721666438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF627 SEMA7A HEATR1 PTGS2 CADM2 FSIP2

4.58e-051721666028a5441242b2cc760cafc1822120180619c63ae
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF627 SEMA7A HEATR1 PTGS2 CADM2 FSIP2

4.58e-0517216669fc70b1a143a8ec910336c23b761d908bb6aecb2
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSCAM ZNF366 LRRK2 MREG PLEKHA2 CD74

4.58e-051721666356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSCAM ZNF366 LRRK2 MREG PLEKHA2 CD74

4.58e-05172166646fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellmild_COVID-19-pDC|World / disease group, cell group and cell class (v2)

SEMA7A FAM186B AJAP1 PARVA SCN9A GNG7

4.58e-051721666dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF627 SEMA7A HEATR1 PTGS2 CADM2 FSIP2

4.58e-05172166613d7117f92a92d77d6b4335ed800c585dc8b4511
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF627 SEMA7A HEATR1 PTGS2 CADM2 FSIP2

4.58e-0517216663d83b2f03ad3af4dae3fe6cc0a0ef356872ca94f
ToppCell3'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF627 SEMA7A HEATR1 PTGS2 CADM2 FSIP2

4.58e-051721666a3d431aed12c1192e8dca1dc85b8340fb7354f8d
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

SEMA7A BICRA IFNAR2 SLC35G1 FAT1 PLXNA2

4.88e-051741666430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ATAD5 ZGRF1 PCLO RHPN2 MKI67 CDT1

5.04e-051751666fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

ATAD5 ZGRF1 PCLO RHPN2 MKI67 CDT1

5.04e-05175166636c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

PTPRC CLEC17A PLEKHA2 CD74 UHRF2 GNG7

5.20e-051761666d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GAS2L3 SCML2 MKI67 COL14A1 SMO MTUS2

5.37e-0517716663e149bff1f1b393a7abe98984e37981c8296f95d
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTL5 E2F2 ADGRE2 PPP1R26 NBEAL2 CD74

5.37e-051771666f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

LRCH2 PCLO LRRK2 SLC35G1 AGER FAM181A

5.37e-051771666d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LRCH2 PCLO LRRK2 SLC35G1 AGER FAM181A

5.37e-051771666ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BCOR CADM2 PPP1R26 PTN AJAP1 LGI1

5.37e-0517716666b4fe717928814dafcd13090b1c90ea973938c6d
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

XRN2 RPS2 FAM186B PTPRC CD8A RPL6

5.54e-051781666934a2a7b35a23b56e34d4d0ef68c271513ef1fe9
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 CADM2 PPP1R26 PTN AJAP1 LGI1

5.54e-0517816663e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPK3 CCDC28B TRAIP ZBTB42 IFNAR2 SCML2

5.71e-051791666327cc39161741ddbc4e8d45b9b3d30b3ce508929
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XRN2 MYCBP2 LRRK2 JMJD1C PTPRC CD74

6.26e-051821666eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GAS2L3 CADM2 PTN AJAP1 MEGF9 LGI1

6.26e-051821666a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell367C-Myeloid-Dendritic-cDC1|367C / Donor, Lineage, Cell class and subclass (all cells)

SEMA7A ZNF366 RAB33A SCN9A GNG7 MTUS2

6.26e-0518216666f5228ac47f9ab46d165740cf2655b5ba217acbe
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM2 PTN ZNF750 AJAP1 PKP1 LGI1

6.46e-0518316664de2082dca2569d3aac3c9b466f27971c82d302b
ToppCelldroplet-Heart-4Chambers-21m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM2 PTN ZNF750 AJAP1 PKP1 LGI1

6.46e-051831666a046b569bc10083d471b420eb2c6fee93437602d
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RPS2 CD8A CD74 RPL6

6.49e-05581664fe3ab0d6f4eeed2f0c98fc9093ed617216549d1b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO PKHD1L1 CADM2 FAT1 SCN9A MYO16

6.65e-0518416662cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO PKHD1L1 CADM2 FAT1 SCN9A MYO16

6.65e-0518416662b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AK7 TG PRDM1 RHPN2 EDEM2 CD74

6.65e-0518416661da7936a2616986efd5de601ad525f1f2355128a
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCLO PKHD1L1 CADM2 FAT1 SCN9A MYO16

6.65e-051841666ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GAS2L3 ATAD5 ZGRF1 TRAIP E2F2 MKI67

6.86e-05185166630e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell10x5'-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

GAS2L3 ZNF366 LRRK2 CD74 SMO MTUS2

6.86e-05185166623ffba9216729b5bdb30b35742ba2627bb1200bf
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 CADM2 PPP1R26 PTN AJAP1 LGI1

7.06e-051861666adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ABL1 SEMA7A ZNF366 RAB33A GNG7 MTUS2

7.06e-051861666962c2dada19185628ead77c32fcb07fa95114247
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 CADM2 PTN AJAP1 SCN9A FAM181A

7.06e-051861666d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCellControl-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ABL1 SEMA7A TCOF1 RAB33A GNG7 MTUS2

7.06e-0518616663de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

MOK SEMA7A MYCBP2 CD46 HEATR1 PTPRC

7.06e-0518616668571956890fc9894d766ba294a28e376b4aba428
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

ABL1 SEMA7A TCOF1 RAB33A GNG7 MTUS2

7.06e-051861666b05c394aa3573ba855abc3066739ca193883b0c3
ToppCelldroplet-Heart-HEART-1m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS2L3 CADM2 TG SLC35G1 GNG7 LGI1

7.06e-051861666fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATAD5 ZGRF1 TRAIP E2F2 PTN MKI67

7.28e-051871666e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCelllymphoid-B_cell-Naive_B_cell|World / Lineage, cell class and subclass

SEMA7A TCOF1 PKHD1L1 PLEKHA2 CD74 GNG7

7.28e-051871666904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATAD5 ZGRF1 TRAIP E2F2 PTN MKI67

7.28e-051871666cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOBP PCLO RASGEF1A ZNF831 TTC3 CRACDL

7.28e-051871666e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOBP PCLO RASGEF1A ZNF831 TTC3 CRACDL

7.28e-05187166624cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCelllymphoid-B_cell|World / Lineage, cell class and subclass

SEMA7A TCOF1 PKHD1L1 PLEKHA2 CD74 GNG7

7.28e-0518716662abbc01fd7f5b4e52113699625287893c991f8da
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOBP PCLO RASGEF1A ZNF831 TTC3 CRACDL

7.28e-0518716662f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CMSS1 TG PRDM1 PTPRC CD8A RPL6

7.49e-05188166676f9b4276455026537a62b0e6d4883ddb68f38ba
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JADE1 AGER NBEAL2 PRDM16 MYO16 PLXNA2

7.49e-051881666eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ABL1 SEMA7A ZNF366 RAB33A GNG7 MTUS2

7.49e-05188166647bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC28B ATAD5 E2F2 CCDC168 MKI67 CDT1

7.49e-051881666319fbeca200ab998daf49fcaee0bfdb57bf7ee4b
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

ABL1 SEMA7A ZNF366 RAB33A GNG7 MTUS2

7.49e-0518816662331a2bae1383820d598e93aa86c75b101069bac
DrugSuccimer

XRN2 SEMA7A KDM5A ATAD5 STXBP5 OAS2 E2F2 JADE1 KMT2E ZNF831 TTC3 JMJD1C PTGS2 ZNF518A PRDM1 IFNAR2 PTPRC GTF3C2 MKI67 OTUD4 CD74 COL14A1 KDM7A SUZ12 IL6ST GSG1

1.81e-06126416726ctd:D004113
Drug2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A

KDM5A ZNF174 TRAIP IFNAR2 CUL5 SCML2 PSME4 ZNF592 NBEAL2 GNG7

1.86e-06195167101665_DN
DrugMagnetite Nanoparticles

XRN2 SEMA7A KDM5A ATAD5 STXBP5 OAS2 E2F2 JADE1 KMT2E ZNF831 TTC3 JMJD1C PTGS2 ZNF518A PRDM1 IFNAR2 PTPRC GTF3C2 MKI67 OTUD4 CD74 COL14A1 KDM7A SUZ12 IL6ST GSG1

3.47e-06131016726ctd:D058185
DiseaseBarrett's esophagus (implicated_via_orthology)

PTGS2 SMO

2.92e-0521602DOID:9206 (implicated_via_orthology)
DiseaseColorectal Carcinoma

TCOF1 ETFDH CD46 ZNF217 PTGS2 FAT1 RHPN2 CCNB3 MKI67 GREM1 UHRF2 RPL6 IL6ST FAM110B

3.09e-0570216014C0009402
Diseasestomach cancer (is_marker_for)

ABL1 KDM5C DAXX CD8A MKI67 SMO

1.29e-041421606DOID:10534 (is_marker_for)
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5A KDM5C

1.74e-0441602DOID:0060809 (implicated_via_orthology)
DiseaseAtherosclerosis

PTGS2 HP AGER LPA

3.00e-04591604C0004153
DiseaseAtherogenesis

PTGS2 HP AGER LPA

3.00e-04591604C1563937
DiseaseTreacher Collins syndrome (implicated_via_orthology)

NOLC1 TCOF1

4.32e-0461602DOID:2908 (implicated_via_orthology)
Diseaseoral squamous cell carcinoma (is_implicated_in)

ABL1 DAXX FAT1

4.64e-04281603DOID:0050866 (is_implicated_in)
Diseasearteriosclerosis (is_implicated_in)

PTGS2 HP IL6ST

6.29e-04311603DOID:2349 (is_implicated_in)
DiseaseMalignant neoplasm of breast

ZNF438 ABL1 ZNF366 ACO2 C1orf87 TTC3 PTGS2 CUL5 PTPRC HP POP1 MKI67 MROH7 CD74 TSC22D4

7.78e-04107416015C0006142
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN9A RAPGEF2

8.01e-0481602C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN9A RAPGEF2

8.01e-0481602C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN9A RAPGEF2

8.01e-0481602C0338479
DiseaseBenign Infantile Myoclonic Epilepsy

SCN9A RAPGEF2

8.01e-0481602C0751120
DiseaseMyoclonic Encephalopathy

SCN9A RAPGEF2

8.01e-0481602C0438414
Diseasesarcoidosis (is_marker_for)

PTGS2 HP

8.01e-0481602DOID:11335 (is_marker_for)
Diseasediffuse large B-cell lymphoma (is_marker_for)

PRDM1 MKI67

8.01e-0481602DOID:0050745 (is_marker_for)
DiseaseMyoclonic Absence Epilepsy

SCN9A RAPGEF2

8.01e-0481602C0393703
Diseaseplasma betaine measurement

NOLC1 KDM5A MYO16

8.28e-04341603EFO_0007787
DiseaseEsophageal Neoplasms

ABL1 PTGS2 ADH7 GNG7

8.69e-04781604C0014859
DiseaseMalignant neoplasm of esophagus

ABL1 PTGS2 ADH7 GNG7

8.69e-04781604C0546837
DiseaseCardiovascular Diseases

PTGS2 HP LPA

9.80e-04361603C0007222
DiseaseProstatic Cancer, Castration-Resistant

CD46 ZNF217

1.03e-0391602C3658266
DiseaseProstatic Neoplasms, Castration-Resistant

CD46 ZNF217

1.03e-0391602C3658267
DiseaseMyoclonic Epilepsy

SCN9A RAPGEF2

1.03e-0391602C0014550
DiseaseDepressive disorder

PDYN PCLO OAS2 PTGS2 TG HP LGI1

1.05e-032891607C0011581
Diseaseatherosclerosis (is_marker_for)

WIZ AGER LPA

1.06e-03371603DOID:1936 (is_marker_for)
Diseasebone quantitative ultrasound measurement

BCAS3 RHPN2 EN1

1.24e-03391603EFO_0004514
DiseaseEpilepsy, Myoclonic, Infantile

SCN9A RAPGEF2

1.28e-03101602C0917800
Diseasevisual epilepsy (biomarker_via_orthology)

PTGS2 PTN SMO IL6ST

1.48e-03901604DOID:11832 (biomarker_via_orthology)
Diseasehypertension

SEMA7A STXBP5 ZNF831 ADH7 ARHGAP31 SBF2 PRDM16

1.48e-033071607EFO_0000537
Diseaseprimary immunodeficiency disease (is_implicated_in)

PTPRC FNIP1 IL6ST

1.54e-03421603DOID:612 (is_implicated_in)
DiseaseBarrett's esophagus (is_marker_for)

PTGS2 MKI67

1.56e-03111602DOID:9206 (is_marker_for)
DiseaseMyoclonic Astatic Epilepsy

SCN9A RAPGEF2

1.56e-03111602C0393702
Diseaseglioblastoma (is_marker_for)

HEATR1 PTGS2 PTN

1.76e-03441603DOID:3068 (is_marker_for)
Diseasefibrinogen measurement, tissue plasminogen activator measurement

STXBP5 JMJD1C FNIP1

1.88e-03451603EFO_0004623, EFO_0004791
Diseasemyocardial infarction (is_implicated_in)

PTGS2 HP AGER LPA

2.10e-03991604DOID:5844 (is_implicated_in)
DiseaseOsteosarcoma

BCOR GRM4 CCNB3

2.13e-03471603C0029463
Diseasesystemic lupus erythematosus (is_marker_for)

CD46 LPA MKI67

2.13e-03471603DOID:9074 (is_marker_for)
DiseaseAdenoid Cystic Carcinoma

BCOR JMJD1C FAT1 EN1

2.18e-031001604C0010606
DiseaseInfantile Severe Myoclonic Epilepsy

SCN9A RAPGEF2

2.19e-03131602C0751122
Diseaseadvanced glycosylation end product-specific receptor, soluble measurement

AGER PRDM16

2.19e-03131602EFO_0020131
Diseasepancreatic cancer (is_marker_for)

PTGS2 AGER MKI67 SMO

2.26e-031011604DOID:1793 (is_marker_for)
Diseasecannabis dependence measurement

ACO2 SLC35G1 SCN9A

2.26e-03481603EFO_0008457
Diseaselung non-small cell carcinoma (is_marker_for)

ABL1 KDM5A PTGS2 AGER MKI67

2.33e-031691605DOID:3908 (is_marker_for)
DiseaseKawasaki disease (is_marker_for)

HP AGER

2.55e-03141602DOID:13378 (is_marker_for)
DiseaseRheumatoid Arthritis

PTGS2 PRDM1 PTPRC AGER IL6ST

2.65e-031741605C0003873
Diseasefree cholesterol to total lipids in small HDL percentage

ZFAND2A ETFDH LPA

2.69e-03511603EFO_0022285
DiseaseMental Depression

PDYN PCLO OAS2 PTGS2 HP LGI1

2.70e-032541606C0011570
Diseaseschizophrenia (biomarker_via_orthology)

KDM5C PTGS2

2.93e-03151602DOID:5419 (biomarker_via_orthology)
DiseaseUnipolar Depression

PDYN PCLO OAS2 PTGS2 TG HP

2.97e-032591606C0041696
Diseasered blood cell density measurement

XRN2 BCAS3 E2F2 ZNF217 JMJD1C TG PTPRC SBF2 OTUD4 CDT1 UHRF2 MYO16

3.17e-0388016012EFO_0007978
DiseaseNeuralgia, Supraorbital

AGER SCN9A

3.34e-03161602C0038870
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5A KDM5C

3.34e-03161602DOID:0050888 (implicated_via_orthology)
DiseaseNeuralgia

AGER SCN9A

3.34e-03161602C0027796
DiseaseDiabetic Angiopathies

HP AGER

3.34e-03161602C0011875
Diseasepancreatic ductal carcinoma (is_implicated_in)

HEATR1 SMO

3.34e-03161602DOID:3587 (is_implicated_in)
DiseaseNeuralgia, Atypical

AGER SCN9A

3.34e-03161602C0234247
DiseaseNeuralgia, Stump

AGER SCN9A

3.34e-03161602C0234249
DiseaseMicroangiopathy, Diabetic

HP AGER

3.34e-03161602C0025945
DiseaseNeuralgia, Iliohypogastric Nerve

AGER SCN9A

3.34e-03161602C0423712
DiseaseNeuralgia, Perineal

AGER SCN9A

3.34e-03161602C0423711
Diseasenervousness

ETFDH CADM2

3.34e-03161602NCIT_C74532
DiseasePolyposis, Adenomatous Intestinal

PTGS2 GREM1

3.34e-03161602C2713442
DiseaseFamilial Intestinal Polyposis

PTGS2 GREM1

3.34e-03161602C2713443
DiseaseParoxysmal Nerve Pain

AGER SCN9A

3.34e-03161602C0751373
DiseaseNerve Pain

AGER SCN9A

3.34e-03161602C0751372
DiseaseNeuralgia, Ilioinguinal

AGER SCN9A

3.34e-03161602C0751371
DiseaseNeuralgia, Vidian

AGER SCN9A

3.34e-03161602C0042656
Diseasebreast cancer (is_marker_for)

KDM5A BCAS3 KDM5C KMT2E MKI67

3.44e-031851605DOID:1612 (is_marker_for)
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

STXBP5 ADH7 FNIP1

3.51e-03561603EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseasedental caries

DSCAM ZGRF1 AJAP1 SCN9A MYO16

3.60e-031871605EFO_0003819
Diseasediabetic neuropathy (biomarker_via_orthology)

LRRK2 PTGS2

3.77e-03171602DOID:9743 (biomarker_via_orthology)
DiseaseAdenomatous Polyposis Coli

PTGS2 GREM1

3.77e-03171602C0032580
Diseasefibrinogen measurement, factor VII measurement

JMJD1C ADH7 RPL6

3.88e-03581603EFO_0004619, EFO_0004623
DiseaseColorectal Neoplasms

PTGS2 FAT1 RHPN2 MKI67 GREM1 IL6ST

4.13e-032771606C0009404
Diseasecolorectal cancer (is_implicated_in)

ABL1 BCOR FAT1 MKI67

4.33e-031211604DOID:9256 (is_implicated_in)
DiseaseChronic myeloproliferative disorder

TRAIP CDT1

4.70e-03191602C1292778
Diseasecerebral infarction (is_marker_for)

AGER LPA

4.70e-03191602DOID:3526 (is_marker_for)
Diseaseacylcarnitine measurement

ETFDH NARS1 CADM2 MYO16

5.13e-031271604EFO_0005059
Diseaseatherosclerosis (biomarker_via_orthology)

HP AGER

5.21e-03201602DOID:1936 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
IQGLKDFTPGKPLKC

ACO2

726

Q99798
VKPGDKVIPLFLPQC

ADH7

96

P40394
KPPSCPLLTKFKELN

ATAD5

886

Q96QE3
KGNNPETKKSIPCPP

ATAD5

1616

Q96QE3
PCPKEIPKESKNTEV

ERVK-19

226

O71037
PCPKEIPKESKNTEV

ERVK-8

226

Q902F8
SLKFRPKGKPCPKEI

ERVK-9

216

Q9UKH3
QKGVGLKTQPESKCP

CUL5

391

Q93034
IPENLPAPTDKCKLK

CAPS2

121

Q9BXY5
QGAPKAKIQPKNPEC

C2orf78

511

A6NCI8
LSPPQKKPQSVGICV

ADAMTSL4-AS1

41

Q5T5F5
QCLPGFKLKPEDPKL

ADGRE2

146

Q9UHX3
SLPCQPGERKKTVKG

GRM4

521

Q14833
GTQKVPKPLCEKGLA

GSG1

41

Q2KHT4
LVPKAGLAKPPAAAK

AJAP1

111

Q9UKB5
PDIPACPSPGQKIKK

CDT1

86

Q9H211
PVPVPSEKTKQPKEC

CMSS1

41

Q9BQ75
KCPRPVVKSGDKPSL

CD8A

216

P01732
CNKIIPPAPFGKTFK

C6orf163

16

Q5TEZ5
HLNIPEVTSPKPKKC

FAM186B

796

Q8IYM0
EVTSPKPKKCKLPAA

FAM186B

801

Q8IYM0
LPPKKPTCPAEKNLL

C1orf94

381

Q6P1W5
SIKAPCKVKPPPQIS

BCAS3

556

Q9H6U6
CAPASRPPAKQQKIK

BCOR

1311

Q6W2J9
GKKEPVVAVEPPLAK

CFAP157

21

Q5JU67
PPESQEKKPLKPCCA

COX17

11

Q14061
HEKNGKKICTLPSPP

DAXX

656

Q9UER7
LKRTCILEPTGKGKP

ATXN7L2

581

Q5T6C5
KAGIKCKPPLCSNSP

ARMC12

36

Q5T9G4
SACKDPLKPLKIRPV

C1orf87

441

Q8N0U7
KCTIEEAPPTKKPLI

CCNB3

476

Q8WWL7
NVEILPPKPDCKLEK

GORAB

121

Q5T7V8
KVPDKNTCPSGIPKP

MTUS2

586

Q5JR59
LPGCVAPPKDTKKGA

MROH7

881

Q68CQ1
GEPLVLKCKGAPKKP

AGER

31

Q15109
LKCKGAPKKPPQRLE

AGER

36

Q15109
PPLVPKVLVGNKCDL

RAB33A

141

Q14088
KVKIVCPPQSPPKNC

RAB40AL

256

P0C0E4
VLPSCKKKAPAETPV

RBM45

376

Q8IUH3
EVQGPPAKKAAVPAK

NOLC1

96

Q14978
KKLECPSPAEQKPAE

OTUD4

551

Q01804
PPRGIIKVKCPYEKV

SPINK14

31

Q6IE38
TISKPCGKLTKPKPQ

PTN

136

P21246
PKCKKESQIFPPTTG

NUBP1

236

P53384
PCLSKKPLEEKPSQP

FAT1

4341

Q14517
KRLKAKTPKNGPPPC

HCFC1

121

P51610
KPVKSQGIPIVCPVS

KDM7A

481

Q6ZMT4
KKCKPVNQPPFLLTS

LEXM

321

Q3ZCV2
LCTPPPKIKNGKHTF

CD46

161

P15529
KLPECEAVCGKPKNP

HP

141

P00738
LNCPELQPPTKKKRV

GREM1

156

O60565
IEKKCVVPAGPPVVS

SBF2

521

Q86WG5
PCKKPSLLKKPEGAS

MYO16

1831

Q9Y6X6
SSLPKQCKQVLLPPK

LRRC53

736

A6NM62
CPADPKKTLGIKLPF

CFAP20

61

Q9Y6A4
PSEEIKECHKPKPIL

ASAH2

491

Q9NR71
KEKFVSRPPTPKCVI

JMJD1C

496

Q15652
LPLKVSPKDNPKPCF

FSIP2

2646

Q5CZC0
RKPAKQKVPLLSCPS

EDEM2

546

Q9BV94
PQLPCDTPKVKQTDG

FAM124A

511

Q86V42
DKTTKTIKEQPQPPC

PCLO

1311

Q9Y6V0
QKPGSPIILKGKNLC

PLXNA2

1156

O75051
VKTQDGPKPINPLIC

PDYN

31

P01213
CTPQNPPQKKKVSLL

KMT2E

1146

Q8IZD2
LTVKVEGCPKHPKGI

LRRK2

1611

Q5S007
VDPVKTPKICKPESG

MEGF9

406

Q9H1U4
VPDDCPTPLGVKGKK

PTGS2

141

P35354
PCIQEKENLGPKPTI

GDPD4

186

Q6W3E5
PVLRPLKCIPASKKT

MOK

381

Q9UQ07
KTTKIACKSPQPDPV

MKI67

2336

P46013
KECERKLKPKGSLPP

OAS2

551

P29728
GCKKEQPPPQLLVAA

EN1

116

Q05925
NKPEKLVAPSPDQKG

MEIOSIN

201

C9JSJ3
PCPKEIPKESKNTEV

ERVK-7

986

P63135
VLPKEEKCPLGTAPA

CRACDL

721

Q6NV74
PLAEKTGICKIRPPK

KDM5A

41

P29375
IKSPLKCTLLPPGQE

IFNAR2

221

P48551
LPQKKSKALPNPEKC

POP1

516

Q99575
PECQSAIKPLKGKVP

ERVK-10

486

P87889
PECQSAIKPLKGKVP

ERVK-19

486

Q9YNA8
PECQSAIKPLKGKVP

ERVK-21

486

P62683
PECQSAIKPLKGKVP

ERVK-24

486

P63145
ECQSAIKPLKGKVPA

ERVK-5

486

Q9HDB9
PECQSAIKPLKGKVP

ERVK-6

486

Q7LDI9
PECQSAIKPLKGKVP

ERVK-7

486

P63130
PECQSAIKPLKGKVP

ERVK-8

486

P62685
PECQSAIKPLKGKVP

ERVK-9

486

P63126
PECQSAIKPLKGKVP

HERVK_113

486

P62684
LKPAKDCTPIEYPKP

ETFDH

496

Q16134
ECPAPVPVKDKKLLE

ATP5MF

6

P56134
ISGLPPEKPKNLSCI

IL6ST

121

P40189
KGKCIRVDGLPSPKT

E2F2

106

Q14209
GVPASENPFKDKKPC

GNG7

51

O60262
SLKFRPKGKPCPKEI

ERVK-24

106

P61566
PCPKEIPKESKNTEV

ERVK-25

226

P61570
PCPKEIPKESKNTEV

ERVK-6

226

Q69384
SLKFRPKGKPCPKEI

ERVK-7

106

P61567
VKKQQPKKPEGTCPA

DBF4B

201

Q8NFT6
PPTIPPAKEVCKAAK

COL14A1

1016

Q05707
SSKCPKLPKANIPVR

GAS2L3

496

Q86XJ1
DGAPQAKPVPAQKLK

GAS2L3

541

Q86XJ1
ESCGPNPGIVRKKKI

FNIP1

316

Q8TF40
LIKCEEDLPTPKPKI

C20orf85

51

Q9H1P6
LTCESKGKPLPEPVL

CADM2

246

Q8N3J6
AKPSQPGEGLKKPVL

ABL1

946

P00519
PLVPEKPKACKVLLT

BAHD1

61

Q8TBE0
CGKPQVEPKKCPGSI

LPA

1806

P08519
SLKFRPKGKPCPKEI

ERVK-21

216

P61565
SLKFRPKGKPCPKEI

ERVK-5

106

Q9HDB8
KPAVLAKPPVCPAAK

FAM110B

76

Q8TC76
RCPNAAPKPEKKDGV

KANSL2

71

Q9H9L4
EPPDKAKPLGTVQQK

HEATR1

1166

Q9H583
PCPKEIPKESKNTEV

HERVK_113

226

Q902F9
KPTDAPPKVLTKCQE

CD74

201

P04233
EKDKPKDRTCILPQP

CCDC168

2871

Q8NDH2
KDRTCILPQPKLEKP

CCDC168

2876

Q8NDH2
KKPPTLQPSKEACFL

BICRA

1071

Q9NZM4
KKRSPKPCLAQPAQA

CCDC28B

6

Q9BUN5
CKGLLPPPEKLTAEV

KLRC4

61

O43908
PLQVPPAQICLKGKV

LRCH2

281

Q5VUJ6
QKVCRPVVLKPIPTK

FAM181A

326

Q8N9Y4
SGQKAIKKCPVRPPS

PKP1

191

Q13835
KDIVLPCKAVGDPSP

DSCAM

1301

O60469
SVPIEIPTIKCKPDK

MRPS30

256

Q9NP92
KEFCGPIPPRVAKKA

RTL5

226

Q5HYW3
PPLEEKKALCKAPSV

PLEKHA2

336

Q9HB19
DPSLPEPKCVKIGAL

NARS1

106

O43776
GQLVVPSKAKAEKPP

TSC22D4

171

Q9Y3Q8
QAKPALKIPQTKACP

TCOF1

631

Q13428
CRKVPKPEALQEKPA

PTCHD1

441

Q96NR3
PKKPGVPCLADGQKE

MREG

191

Q8N565
GKQNKRVCGKILPSP

OVCH1

366

Q7RTY7
LTKLVAELKGCPPPQ

NBEAL2

111

Q6ZNJ1
CPFDLTTKPKDVKPI

PRDM16

771

Q9HAZ2
CNEATPIKNPPTGKK

PIP4P2

81

Q8N4L2
PILNSKPPDCDPKKV

SCN9A

1706

Q15858
EPPPFKCLLINKVDG

MYCBP2

1096

O75592
PLSKTPDPLLGCKRK

PPP1R26

581

Q5T8A7
PSTEKNELCPKNVPK

PRDM1

231

O75626
SKPCLIKKEPPAGDL

WIZ

1276

O95785
ALGVQPKCLLCPKKG

JADE1

251

Q6IE81
KPKPRPEDIVNCDLK

PARVA

341

Q9NVD7
GKKPEPCKPILKVEF

STXBP5

286

Q5T5C0
VGAARPQVKKKLPSP

RHPN2

661

Q8IUC4
PECQSAIKPLKGKVP

ERVK-9

486

P63128
PRAAKETEKPPLPCK

CLEC17A

101

Q6ZS10
ALAQKSPAPKVRKPG

C15orf39

951

Q6ZRI6
KKVPVKDLPPFGINS

RAPGEF2

1066

Q9Y4G8
QIEAKPCSNSPPKVK

UHRF2

86

Q96PU4
RVPKCPKSNSLDPKQ

ZNF750

61

Q32MQ0
VCPLCNTPIPVKKGQ

ZFAND2A

56

Q8N6M9
EGILGKPCPKIKVEC

WFDC6

26

Q9BQY6
LGISPKCVIKELPPT

ZNF616

46

Q08AN1
KLEEKRGPPLQKNCP

ZNF174

26

Q15697
VDKGPILKTKPPAAQ

RASGEF1A

191

Q8N9B8
LSCLEPPLKTAPKGV

PHF21B

376

Q96EK2
KPKKGKPHCSRNPVL

RPL6

36

Q02878
KLNLEEPPSSVPKKC

RIPK3

351

Q9Y572
PNSGKKEKPLPVICS

SCML2

311

Q9UQR0
LPKTGCVIQPVPKPA

SOBP

821

A7XYQ1
CPIRQVPTGKKQVPL

SUZ12

201

Q15022
CKKEPKPEPLPLGSQ

ZNF592

201

Q92610
PLPQVEKKLKCTVEG

ZNF410

211

Q86VK4
KLKDFPVCVSTKPEP

WASH4P

151

A8MWX3
IREEFKPNKPKPCGL

XRN2

251

Q9H0D6
AIQPKEGDIPKSPKQ

TXNDC2

366

Q86VQ3
EGDIPKSPKQAIQPK

TXNDC2

371

Q86VQ3
KSPKQAIQPKEGDIP

TXNDC2

376

Q86VQ3
PCPKEIPKESKNTEV

ERVK-10

986

P10266
KVPPRPILKQKCSSL

TTC3

746

P53804
IPDGILNKKTPGVKP

ZNF627

86

Q7L945
CPNPKPDKAPLQKVS

SEMA7A

541

O75326
AKLQLKSTECGPPKG

ARHGAP31

1086

Q2M1Z3
PSVGAARPQVKKKLP

RHPN2P1

556

A8MT19
ICCKTPPKPHILKTV

PKHD1L1

321

Q86WI1
KEPCKTPILKVEPNN

ZNF518A

1006

Q6AHZ1
KLTINPCEISGCPKP

PSME4

1221

Q14997
IGLPTKQPIPDCEIK

SMO

496

Q99835
CPAARKAKLPPFGVK

ZBTB42

151

B2RXF5
KPVKVLGPSLVSPQC

ZNF621

346

Q6ZSS3
PPVKKLPEKEHGKIC

ZKSCAN4

271

Q969J2
GGKPVKQEPIKPSAV

ZNF366

146

Q8N895
VIPKQIERKTCDPKP

ZGRF1

921

Q86YA3
LGKDVPPLSSFCKPK

ZNF217

761

O75362
RTEPEAKKKAPCPGL

SLC35G1

56

Q2M3R5
PTKPKKIRQPAACPG

GTF3C2

221

Q8WUA4
CKAAGKEVPLPSNPI

WDR3

781

Q9UNX4
PKTEKCTTEGQQKPP

VEZT

36

Q9HBM0
LPEQKSPTAGKPCAL

ZNF831

301

Q5JPB2
GNKIGKPHTVPCKVT

RPS2

171

P15880
CVNPLGAPEKLPEAK

PTPRC

1261

P08575
GKPKKCPTPCQLQSE

TG

721

P01266
KPILIFPKSGCSKAP

ZNF438

136

Q7Z4V0
KQLAVAEGKPPEAPK

MARS1

881

P56192
CKTKDATPQPDILPK

ZNF114

51

Q8NC26
HSPIQDVPKKICKGP

TRAIP

346

Q9BWF2
TLRKKDKEGPECPPT

KDM5C

256

P41229
CISKNTGPGKIQKIP

AK7

291

Q96M32
LTEGKKPAKPKCPAV

LGI1

31

O95970