Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkinase activity

DCAF1 TSSK6 BAZ1B IP6K1 TEK PTK2 ITPKB MAPK15 BRD2 TIE1 EPHA2 AK4 DMPK

2.24e-0476410713GO:0016301
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

DCAF1 TSSK6 BAZ1B IP6K1 TEK PTK2 ITPKB MAPK15 BRD2 TIE1 EPHA2 DMPK

4.15e-0470910712GO:0016773
GeneOntologyMolecularFunctionATP-dependent activity

ABCA4 CENPE VWA8 KIF1B YTHDC2 ERCC6L2 MYO15A SNRNP200 HSPA6 HSPA7 ABCC10

4.56e-0461410711GO:0140657
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

DCAF1 TSSK6 POLRMT BAZ1B IP6K1 TEK PTK2 ITPKB MAPK15 BRD2 TIE1 EPHA2 AK4 DMPK

4.81e-0493810714GO:0016772
DomainK_chnl_volt-dep_Kv9

KCNG3 KCNG4

6.95e-0471092IPR003971
DomainIPK

IP6K1 ITPKB

6.95e-0471092PF03770
DomainIPK

IP6K1 ITPKB

6.95e-0471092IPR005522
DomainTyrKc

TEK PTK2 TIE1 EPHA2

1.76e-03881094SM00219
DomainTyr_kinase_cat_dom

TEK PTK2 TIE1 EPHA2

1.76e-03881094IPR020635
DomainDUF4599

SPATA31C2 SPATA31A6

2.14e-03121092PF15371
DomainDUF4599

SPATA31C2 SPATA31A6

2.14e-03121092IPR027970
DomainGrowth_fac_rcpt_

TEK TIE1 EPHA2 SLIT3 LTBP2

2.22e-031561095IPR009030
DomainPROTEIN_KINASE_TYR

TEK PTK2 TIE1 EPHA2

2.51e-03971094PS00109
DomainTyr_kinase_AS

TEK PTK2 TIE1 EPHA2

2.51e-03971094IPR008266
DomainHSP70

HSPA6 HSPA7

3.84e-03161092PF00012
DomainP-loop_NTPase

ABCA4 CENPE VWA8 KIF1B YTHDC2 DYNC2LI1 ERCC6L2 AK4 MYO15A REM2 SNRNP200 ABCC10

3.91e-0384810912IPR027417
Domain-

FSTL4 EFCAB3 S100A4 MINDY3 SPOCK3 UTRN

4.29e-0326110961.10.238.10
DomainEGF-like_CS

TEK NRXN1 TIE1 EPHA2 SLIT3 LTBP2

4.29e-032611096IPR013032
DomainHSP70_2

HSPA6 HSPA7

4.33e-03171092PS00329
DomainHSP70_3

HSPA6 HSPA7

4.33e-03171092PS01036
DomainHSP70_1

HSPA6 HSPA7

4.33e-03171092PS00297
DomainAnkyrin_rpt

MRM1 YTHDC2 ANKRD55 SOWAHA ANKRD61 TP53BP2

4.37e-032621096IPR002110
DomainFN3

LRIT2 TEK TIE1 EPHA2 IL21R

4.60e-031851095SM00060
DomainEGF_2

TEK NRXN1 TIE1 EPHA2 SLIT3 LTBP2

4.62e-032651096PS01186
DomainHsp_70_fam

HSPA6 HSPA7

4.86e-03181092IPR013126
DomainEGF_extracell

TEK TIE1 LTBP2

5.20e-03601093IPR013111
DomainEGF_2

TEK TIE1 LTBP2

5.20e-03601093PF07974
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

USP34 TOPAZ1 BCLAF1 DOCK10 EFCAB3 TEK MAPK15 TIE1 EPHA2 EIF4G2 SPEN

1.23e-074201121128065597
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 AHCTF1 USP24 POLRMT BAZ1B YTHDC2 URB1 EIF3D PLEC SPEN UTRN SNRNP200

1.39e-066531121222586326
Pubmed

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.

TEK TIE1 EPHA2

3.84e-0610112310323857
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DCAF1 TTC28 KIF1B DOCK10 ARHGEF17 EPG5 BTBD7 SPEN PDZD2

7.16e-06407112912693553
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

USP34 TTC28 USP24 ZNF507 POLRMT PLEC UTRN HSPA6 TP53BP2

8.86e-06418112934709266
Pubmed

Tie-1: A potential target for anti-angiogenesis therapy.

TEK TIE1

1.03e-052112226489611
Pubmed

The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.

HSPA6 HSPA7

1.03e-05211221346391
Pubmed

Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

TEK TIE1

1.03e-052112210995770
Pubmed

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.

TEK TIE1

1.03e-05211228395828
Pubmed

Activation of erythropoietin-producing hepatocellular receptor A2 attenuates cell adhesion of human fallopian tube epithelial cells via focal adhesion kinase dephosphorylation.

PTK2 EPHA2

1.03e-052112222009484
Pubmed

Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs.

TEK TIE1

1.03e-052112215893943
Pubmed

A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.

EIF4G2 EIF3D

1.03e-052112234848685
Pubmed

Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation.

EIF4G2 EIF3D

1.03e-052112237314929
Pubmed

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

TEK TIE1

1.03e-05211228846781
Pubmed

Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells.

FSTL4 NYX

1.03e-052112231513577
Pubmed

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

TEK TIE1

1.03e-05211221312667
Pubmed

Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.

EIF4G2 EIF3D

1.03e-052112237144468
Pubmed

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.

TEK TIE1

1.03e-052112217504972
Pubmed

Receptive Field Sizes of Nyxnob Mouse Retinal Ganglion Cells.

FSTL4 NYX

1.03e-052112235328623
Pubmed

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

TEK TIE1

1.03e-052112214530387
Pubmed

Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.

TEK TIE1

1.03e-052112220227369
Pubmed

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

IP6K1 PTK2

1.03e-052112228154132
Pubmed

Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues.

TEK TIE1

1.03e-05211229108247
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

USP34 VWA8 KIF1B URB1 NRXN1

2.37e-0510511259628581
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

USP34 CENPE ZNF507 SMYD4 EIF4G2 PLEC TNS1 UTRN

2.41e-05363112814691545
Pubmed

A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.

TEK TIE1

3.08e-053112232822567
Pubmed

Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.

PTK2 EPHA2

3.08e-053112217332925
Pubmed

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.

TEK TIE1

3.08e-053112226344773
Pubmed

Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.

TEK TIE1

3.08e-053112222342979
Pubmed

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

PTK2 EPHA2

3.08e-053112212467573
Pubmed

Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex.

TEK TIE1

3.08e-053112211866538
Pubmed

ASPP2 suppresses stem cell-like characteristics and chemoresistance by inhibiting the Src/FAK/Snail axis in hepatocellular carcinoma.

PTK2 TP53BP2

3.08e-053112227473084
Pubmed

Primary Congenital Glaucoma

TEK LTBP2

3.08e-053112220301314
Pubmed

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.

PTK2 TNS1

3.08e-05311229553131
Pubmed

Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78.

PTK2 EIF3D

3.08e-053112235104170
Pubmed

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.

TEK TIE1

3.08e-053112227941161
Pubmed

Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1.

TEK TIE1

3.08e-053112223504320
Pubmed

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

TEK TIE1

3.08e-053112217728252
Pubmed

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.

TEK TIE1

3.08e-05311227596437
Pubmed

Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

TEK TIE1

3.08e-053112210498691
Pubmed

A unique pattern of Tie1 expression in the developing murine lung.

TEK TIE1

3.08e-053112212554357
Pubmed

Tie1 controls angiopoietin function in vascular remodeling and inflammation.

TEK TIE1

3.08e-053112227548530
Pubmed

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.

TEK TIE1

3.08e-053112222235284
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

BCLAF1 AHCTF1 BAZ1B YTHDC2 ORC2 SPEN SNRNP200

3.84e-05283112730585729
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

BCLAF1 KIF1B USP24 ZNF507 BAZ1B YTHDC2 BRD2 EIF4G2 PLEC SPEN SNRNP200

4.23e-057741121115302935
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

YTHDC2 SNRNP200 HSPA6 HSPA7

4.62e-0561112419875381
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

WDR4 VWA8 PTK2 URB1 DMPK SNRNP200

5.11e-05202112624639526
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

BCLAF1 KIF1B YTHDC2 GRIN2A PLEKHA6 ARHGEF17 ITPKB AGBL4 EIF4G2 PLEC TNS1 UTRN SNRNP200 TP53BP2 UQCRFS1P1

5.65e-0514311121537142655
Pubmed

Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.

TEK TIE1

6.14e-054112220164029
Pubmed

The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta.

TEK TIE1

6.14e-054112218675456
Pubmed

lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A reader YTHDC2.

YTHDC2 TNS1

6.14e-054112236581942
Pubmed

Signaling and functions of angiopoietin-1 in vascular protection.

TEK TIE1

6.14e-054112216645151
Pubmed

A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis.

TEK TIE1

6.14e-054112211172728
Pubmed

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.

PLEC UTRN

6.14e-054112217389230
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

CENPE BCLAF1 AHCTF1 BAZ1B PLEC SNRNP200

6.34e-05210112616565220
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

TTC28 VWA8 NRXN1 SNRNP200 PDZD2

6.58e-05130112512421765
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TTC28 BCLAF1 AHCTF1 USP24 BAZ1B SPEN SNRNP200 HSPA6 TP53BP2

7.42e-05549112938280479
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

EPG5 EIF4G2 SNRNP200 TP53BP2

7.50e-0569112432238831
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

GLI2 SLIT3 LTBP2 SPAG17 TNS1

8.15e-05136112525429064
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

USP34 TTC28 DOCK10 URB1 NRXN1 SNRNP200

9.27e-05225112612168954
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

PCDHA2 ZP2 URB1 LTBP2 EIF3D SPEN TP53BP2

9.86e-05329112717474147
Pubmed

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

TEK TIE1 EPHA2

1.00e-0428112318593464
Pubmed

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.

KCNG3 KCNG4

1.02e-045112219074135
Pubmed

TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth.

TEK TIE1

1.02e-04511229683559
Pubmed

Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.

POLRMT MRPS27

1.02e-045112222003127
Pubmed

Role of dystrophins and utrophins in platelet adhesion process.

PTK2 UTRN

1.02e-045112216803572
Pubmed

Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma.

TEK TIE1

1.02e-045112217724803
Pubmed

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.

PTK2 EPHA2

1.02e-045112210655584
Pubmed

Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development.

TEK TIE1

1.02e-04511227647376
Pubmed

USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.

USP24 BRD2

1.02e-045112233257797
Pubmed

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

PLEKHA6 PTK2 EPHA2 PLEC

1.04e-0475112415951569
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DCAF1 AHCTF1 POLRMT DOCK10 BAZ1B PTK2 URB1 EIF4G2 EIF3D PLEC UTRN SNRNP200 HSPA6 TP53BP2

1.17e-0413531121429467282
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

USP34 BCLAF1 SOWAHA PLEC SNRNP200 HSPA6

1.18e-04235112630258100
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CFAP47 CENPE TOPAZ1 ARHGEF17 URB1 KCNG4 TBC1D14 EIF3D UTRN SNRNP200

1.38e-047361121029676528
Pubmed

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

DCAF1 HSPA6 HSPA7

1.51e-0432112318850735
Pubmed

Further analysis of the lens of ephrin-A5-/- mice: development of postnatal defects.

EPHA2 MIP

1.53e-046112223401654
Pubmed

Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells.

TEK TIE1

1.53e-046112218439490
Pubmed

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

TEK TIE1

1.53e-046112216189264
Pubmed

Contribution of the PI3K/MMPs/Ln-5γ2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.

PTK2 EPHA2

1.53e-046112223588386
Pubmed

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation.

TEK TIE1

1.53e-046112210446940
Pubmed

Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.

TEK TIE1

1.53e-04611228661721
Pubmed

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.

TEK TIE1

1.53e-04611227596436
Pubmed

p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.

PTK2 TNS1

1.53e-04611228810278
Pubmed

The protein tyrosine kinase family of the human genome.

TEK PTK2 TIE1 EPHA2

1.54e-0483112411114734
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

CENPE BCLAF1 IP6K1 YTHDC2 S100A4 ZMYND10 SPEN

1.75e-04361112726167880
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

USP34 BCLAF1 PTK2 MAPK15 BRD2 EPHA2 EIF3D PLEC DMPK TNS1 UTRN

1.76e-049101121136736316
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

TSSK6 ISX PTK2 MAPK15 TIE1 EPHA2 DMPK

2.10e-04372112722939624
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CENPE TOPAZ1 MRM1 POLRMT MRPS27 YTHDC2 SPATA31A6 ERCC6L2

2.13e-04497112836774506
Pubmed

Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

KCNG3 KCNG4

2.14e-047112212060745
Pubmed

Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.

TEK TIE1

2.14e-047112211813303
Pubmed

Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.

TEK TIE1

2.14e-047112211566878
Pubmed

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

TEK TIE1

2.14e-047112227695111
Pubmed

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.

EIF4G2 EIF3D

2.14e-047112211331597
Pubmed

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

TEK TIE1

2.14e-047112211344305
Pubmed

Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice.

TEK TIE1

2.14e-047112210027415
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

TTC28 AHCTF1 YTHDC2 EPHA2 UTRN TP53BP2

2.16e-04263112634702444
Pubmed

Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.

BCLAF1 AHCTF1 ORC2 GLI2

2.20e-0491112421194568
Pubmed

COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway.

TEK PTK2

2.84e-048112225792870
Pubmed

Role of vascular endothelial-cadherin in vascular morphogenesis.

TEK TIE1

2.84e-048112210207135
Pubmed

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.

TEK TIE1

2.84e-048112215644447
InteractionTEK interactions

AHCTF1 MRPS27 BAZ1B YTHDC2 TEK PTK2 TIE1

3.15e-061191067int:TEK
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 BCLAF1 AHCTF1 USP24 DOCK10 EPG5 SPEN UTRN TP53BP2

1.12e-091881119ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellKidney-Fibroblasts|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

TSSK6 TOPAZ1 PCDHB15 S100A4 GLI2 LTBP2 GPNMB

7.09e-0720011172c265ad8314a21bce50ac21b16da2fea125366ea
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF17 PTK2 TYMS NRXN1 KCNG4 PDZD2

4.65e-06172111603a0aff6b7971093a4347b5ed12546d78374c56f
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOWAHA ZMYND10 DYNC2LI1 GPNMB DMPK SPEN

5.48e-06177111614fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EFCAB3 MAPK15 WDR97 ZMYND10 CFAP119 SPAG17

5.66e-0617811163b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 CFAP119 SPAG17

6.22e-061811116dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PTCHD4 ANKRD55 SPOCK3 UTRN SLC29A4

7.27e-061861116310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

USP34 TTC28 VWA8 PTK2 COG5 UTRN

1.07e-05199111694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte|GW12 / Sample Type, Dataset, Time_group, and Cell type.

WDR4 AHCTF1 USP24 SPOCK3 GLI2 PDZD2

1.10e-052001116b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ZP2 TYMS GLI2 SLIT3 LTBP2

3.84e-05151111532d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D2|343B / Donor, Lineage, Cell class and subclass (all cells)

TAGAP GPR82 DOCK10 HSPA6 PDE11A

4.08e-0515311150b3b199678d4a70b0590393568c69454bece5c14
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE TAGAP GPR82 DOCK10 AGBL4

4.48e-051561115af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FSTL4 GRIN2A CFAP119 REM2 SLC29A4

5.85e-0516511154b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 AGBL4 MAPK15 CFAP119 SPAG17

6.55e-051691115fba841664939c771881ba97f14ef1df6635c04ff
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP47 GPR82 MAPK15 ZMYND10 SPAG17

6.92e-0517111154f2a83d8091f1fd29542d2e5add57fd482e921b5
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF17 NRXN1 LTBP2 TNS1 PDZD2

7.31e-051731115f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC35G2 PTCHD4 ANKRD55 AGBL4 SLC29A4

7.31e-0517311157e3897868dd3f6e4974f593c60649a543ffc8693
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF17 NRXN1 LTBP2 TNS1 PDZD2

7.31e-051731115cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCDHB15 SOWAHA SPOCK3 PDE11A PDZD2

7.52e-051741115b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PCDHB15 SOWAHA SPOCK3 PDE11A PDZD2

7.52e-05174111571730503be3d9c839c4c9e950145e2101d682a1c
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PCDHB15 SOWAHA SPOCK3 PDE11A PDZD2

7.52e-051741115ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDHB15 PCDHA2 TEK TIE1 HRH1

7.52e-05174111540bb87d219aafab0357ab0d797efd38085fc0312
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCDHB15 SOWAHA SPOCK3 PDE11A PDZD2

7.52e-051741115cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2 EPHA2 IL21R HRH1 TNS1

7.93e-051761115d4075796c38b775fe721abb47426e662a0d415e3
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF17 PTK2 NRXN1 LTBP2 PDZD2

7.93e-051761115e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGEF17 PTK2 NRXN1 LTBP2 PDZD2

7.93e-051761115f931192e3cc65414e2245354f443473696cc7ce8
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOWAHA ZMYND10 DYNC2LI1 DMPK SPEN

7.93e-0517611155e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCLAF1 BAZ1B ITPKB BTBD7 UTRN

8.37e-05178111501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

8.37e-051781115de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA4 TEK TIE1 EPHA2 UTRN

8.59e-051791115a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAPK15 NRXN1 WDR97 ZMYND10 SPAG17

8.59e-0517911155e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 FSTL4 PTCHD4 ITPKB AGBL4

8.59e-051791115666072c0e8448dbaec1683d18368ec2502453f90
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 PTK2 NRXN1 LTBP2 PDZD2

8.82e-0518011150153667e44fdbc3c0d444dcb023069925a2b69a2
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF17 PTK2 NRXN1 LTBP2 PDZD2

8.82e-05180111540a28b410f46215d6d7cf8a02a18078eb046b5b0
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEK ITPKB TIE1 BTBD7 UTRN

9.05e-05181111592d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FSTL4 GRIN2A PTCHD4 PDZD2

9.05e-0518111159d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

9.29e-0518211157ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Deuterosomal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

9.29e-051821115000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 FSTL4 GRIN2A PTCHD4 PDZD2

9.29e-051821115eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

CENPE GPR82 SLIT3 CFAP119 DMPK

9.29e-0518211158dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRIN2A ARHGEF17 GLI2 SLIT3 UTRN

1.00e-04185111551dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TTC28 DOCK10 ANKRD55 SPOCK3 SLC29A4

1.00e-041851115027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.00e-04185111530f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.00e-0418511153e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GRIN2A ARHGEF17 GLI2 SLIT3 UTRN

1.00e-041851115a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCellCOPD-Epithelial-Ciliated|COPD / Disease state, Lineage and Cell class

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.05e-041871115f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.05e-0418711159e10ed56090d82589bc457788282f664b70ace4b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.08e-04188111561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.08e-041881115789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.08e-0418811152b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.11e-04189111568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.11e-041891115c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

PCDHA2 S100A4 NRXN1 REM2 ABCC10

1.11e-0418911153717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PTCHD4 ANKRD55 SPOCK3 UTRN

1.11e-041891115f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellControl-Endothelial-Endothelial-Alv_Gen_Intermediate|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.11e-0418911155d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.11e-04189111527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.14e-041901115a3c6eec6df052105ab78b7e3c78f94218d5912eb
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF17 PTK2 NRXN1 LTBP2 PDZD2

1.14e-04190111510b02c62e72bfea9767e3e751011436925da823e
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.14e-041901115106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PTCHD4 ANKRD55 SPOCK3 UTRN

1.16e-0419111157b386512284dfaa0e95358b28ee82632ee965e64
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PTCHD4 ANKRD55 SPOCK3 UTRN

1.16e-041911115fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DOCK10 ARHGEF17 PTK2 NRXN1 PDZD2

1.16e-0419111152ad717b59215ad8d933e9637d363b65d7298e5d4
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.19e-04192111504f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.19e-041921115c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.19e-041921115d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.19e-041921115eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CENPE TYMS IL21R SLIT3 CFAP119

1.22e-0419311155f5904cec8b2967154ef2eab3c48f51df53aca4a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 GRIN2A PTCHD4 ANKRD55 UTRN

1.25e-04194111552aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.25e-04194111543f92b0533e26633dc94cce554045d641ef8fd76
ToppCellControl-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.25e-041941115958e648138676d46698090b4046cb484083ae449
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 GRIN2A PTCHD4 ANKRD55 UTRN

1.25e-041941115bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEK ITPKB TIE1 SPOCK3 HRH1

1.25e-0419411151d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 AGBL4 MAPK15 CFAP119 SPAG17

1.25e-0419411154a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PTCHD4 ANKRD55 SPOCK3 SLC29A4

1.25e-0419411154f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

AGBL4 MAPK15 ZMYND10 CFAP119 SPAG17

1.28e-04195111560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

CFAP47 PTK2 TYMS AGBL4 SPAG17

1.31e-041961115af4cdc61830685a888a1209826c23bcf54a43084
ToppCellproximal-Hematologic-Interstitial_Macrophage|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CENPE DOCK10 GPNMB HSPA6 HSPA7

1.31e-041961115b6a858c43fef42cd724d56c8283e954bcb546106
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF17 LTBP2 DMPK TNS1 PDZD2

1.31e-0419611154740ef6e428f1ccc81fc98c3b868afd38ce60535
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

CFAP47 PTK2 TYMS AGBL4 SPAG17

1.31e-0419611156d02d494196e3f857d53eea46d9419690d43beca
ToppCellproximal-3-Hematologic-Interstitial_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CENPE DOCK10 GPNMB HSPA6 HSPA7

1.31e-041961115d8c9cb86233470c3044865ad05ea202e294d80bf
ToppCellproximal-Hematologic-Interstitial_Macrophage-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CENPE DOCK10 GPNMB HSPA6 HSPA7

1.31e-0419611159d4d8ffe9d30de7d1dc33d261bc2aaf4189ad86c
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP47 MAPK15 ZMYND10 SPAG17 SLC29A4

1.35e-0419711156e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TEK S100A4 TIE1 PLEC UTRN

1.41e-041991115a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Cilia-bearing_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

ABCA4 MAPK15 ZMYND10 SLIT3 SPAG17

1.41e-0419911152d8ab4aee300c7c4baf662940ce855da2b6d2cae
ToppCelldistal-Epithelial-Ciliated-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFAP47 MAPK15 ZMYND10 CFAP119 SPAG17

1.41e-0419911152de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TEK S100A4 TIE1 PLEC UTRN

1.41e-0419911159b02acae6325b0ac9642438a4431285ff396e5fe
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AGBL4 MAPK15 ZMYND10 CFAP119 SPAG17

1.41e-04199111515f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 TEK ANKRD55 NRXN1 PDZD2

1.41e-04199111519a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DOCK10 S100A4 TNS1 UTRN HSPA7

1.41e-041991115379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_2-VSMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGEF17 S100A4 SLIT3 DMPK TNS1

1.44e-042001115fc802dd73f048881d9ddafd1b79ab3ca654510e2
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 MAPK15 ZMYND10 CFAP119 SPAG17

1.44e-042001115cc906ff02fd335ff633b3b97afceb670494f910a
ToppCellcellseq2-Mesenchymal-Myocytic-Myocytic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGEF17 S100A4 SLIT3 DMPK TNS1

1.44e-042001115cffddb39960cd611428397c1ec4023192e8af5a7
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP47 MAPK15 ZMYND10 CFAP119 SPAG17

1.44e-04200111579e59ab31d3d3385b1b072dc75508af9546c2e1b
ToppCellcellseq2-Mesenchymal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGEF17 S100A4 SLIT3 DMPK TNS1

1.44e-0420011156b558cce0d6047c7e85f428adff80c5ca3084ea4
ToppCellBronchus_Control_(B.)-Epithelial-TX-Ciliated|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CFAP47 MAPK15 ZMYND10 CFAP119 SPAG17

1.44e-0420011156a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF17 SLIT3 AK4 LTBP2 PDZD2

1.44e-04200111536de49593cf6ff1c9229fcceb150c1d68658a360
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP47 AGBL4 MAPK15 ZMYND10 SPAG17

1.44e-04200111585c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

ABCA4 ZMYND10 GPNMB SPAG17 PDE11A

1.44e-0420011155fb90118d3abc28d72bc483e68317255090a04c7
ToppCellBiopsy_Control_(H.)-Epithelial-Differentiating_Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CFAP47 MAPK15 ZMYND10 CFAP119 SPAG17

1.44e-042001115a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

DOCK10 PTCHD4 ANKRD55 SPOCK3 UTRN

1.44e-042001115862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
DiseaseGlaucoma 3, primary infantile, B

TEK LTBP2

3.83e-0531062cv:C1832977
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

3.83e-0531062600975
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

3.83e-0531062C1832977
DiseaseHydrophthalmos

TEK LTBP2

1.27e-0451062C0020302
Diseaseacute kidney tubular necrosis (biomarker_via_orthology)

TEK AK4

1.27e-0451062DOID:12556 (biomarker_via_orthology)
DiseaseParoxysmal atrial fibrillation

USP34 PTK2 AGBL4 SLIT3 COG5

2.55e-041561065C0235480
Diseasefamilial atrial fibrillation

USP34 PTK2 AGBL4 SLIT3 COG5

2.55e-041561065C3468561
DiseasePersistent atrial fibrillation

USP34 PTK2 AGBL4 SLIT3 COG5

2.55e-041561065C2585653
DiseaseB-cell lymphoma (is_implicated_in)

BRD2 IL21R

2.65e-0471062DOID:707 (is_implicated_in)
DiseaseAtrial Fibrillation

USP34 PTK2 AGBL4 SLIT3 COG5

2.87e-041601065C0004238
DiseasePosterior subcapsular cataract

EPHA2 MIP

3.53e-0481062C0858617
Diseaseatrial fibrillation

USP34 KIF1B PTK2 AGBL4 SLIT3 COG5 SPEN

3.94e-043711067EFO_0000275
DiseaseChildhood Medulloblastoma

S100A4 SMYD4 BRD2

5.01e-04431063C0278510
DiseaseMelanotic medulloblastoma

S100A4 SMYD4 BRD2

5.01e-04431063C1275668
DiseaseMedullomyoblastoma

S100A4 SMYD4 BRD2

5.01e-04431063C0205833
DiseaseDesmoplastic Medulloblastoma

S100A4 SMYD4 BRD2

5.01e-04431063C0751291
DiseaseAdult Medulloblastoma

S100A4 SMYD4 BRD2

5.01e-04431063C0278876
Diseaseimmature platelet count

DOCK10 TBC1D14 AK4 PLEC

5.90e-041061064EFO_0803544
Diseaseserum IgG glycosylation measurement

TOPAZ1 TEK ANKRD55 BRD2 SLIT3 TBC1D14 ERCC6L2 HRH1

6.10e-045231068EFO_0005193
DiseaseSemantic-Pragmatic Disorder

GRIN2A NRXN1

6.88e-04111062C0454655
Diseasediet measurement, adiponectin measurement

SPOCK3 PDE11A

6.88e-04111062EFO_0004502, EFO_0008111
DiseaseAuditory Processing Disorder, Central

GRIN2A NRXN1

6.88e-04111062C0751257
DiseaseLanguage Delay

GRIN2A NRXN1

6.88e-04111062C0023012
DiseaseLanguage Development Disorders

GRIN2A NRXN1

6.88e-04111062C0023014
DiseaseSpeech Delay

GRIN2A NRXN1

6.88e-04111062C0241210
Diseaseimmature platelet fraction

KIF1B DOCK10 TBC1D14 PLEC

7.75e-041141064EFO_0009187
DiseaseMedulloblastoma

S100A4 SMYD4 BRD2

7.81e-04501063C0025149
Diseaseegg allergy measurement, parental genotype effect measurement

SPATA31C2 ANKRD55

9.72e-04131062EFO_0005939, EFO_0007018
Diseasegamma-glutamylglutamate measurement

TEK ABCC10

1.13e-03141062EFO_0021137
Diseaseneurofilament light chain measurement

VWA8 EIF4G2 MYO15A

1.15e-03571063EFO_0009178
Diseaseserum albumin measurement

IP6K1 MSANTD1 EPHA2 MIP PLEC HSPA6 HSPA7 PDE11A

1.35e-035921068EFO_0004535
DiseaseCongenital total cataract

EPHA2 MIP

1.48e-03161062C0266539
Diseaseanthranilic acid measurement

KIF1B COG5

1.48e-03161062EFO_0010460
Diseasemacrophage inflammatory protein 1b measurement

DCAF1 TOPAZ1 MRM1 IP6K1

1.49e-031361064EFO_0008219
Diseasesusceptibility to hepatitis B infection measurement

YTHDC2 GRIN2A MINDY3

1.60e-03641063EFO_0008405
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

HSPA6 HSPA7

1.68e-03171062EFO_0021969
DiseaseNuclear cataract

EPHA2 MIP

1.88e-03181062C0392557
DiseaseNuclear non-senile cataract

EPHA2 MIP

1.88e-03181062C1112705
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

USP24 NRXN1

2.10e-03191062OBA_2045199
Diseaseacetone measurement

VWA8 AK4

2.10e-03191062EFO_0010989
DiseaseChronic myeloproliferative disorder

WDR4 CENPE

2.10e-03191062C1292778
Diseasebody surface area

SPATA31C2 KCNG3 AGBL4 GLI2 SLIT3 LTBP2 PLEC PDE11A

2.26e-036431068EFO_0022196
DiseaseSeckel syndrome

WDR4 CENPE

2.82e-03221062C0265202
Diseasecardioembolic stroke

USP34 DOCK10 TEK PTK2

3.35e-031701064EFO_1001976
Diseasemortality

TTC28 FSTL4 HRH1 PDZD2

3.56e-031731064EFO_0004352

Protein segments in the cluster

PeptideGeneStartEntry
FTDPLLAKERVLSNL

EPG5

1486

Q9HCE0
FKLFRVLPTLLDSRS

ABCA4

251

P78363
KTARLLSSEDRARLP

BAZ1B

501

Q9UIG0
LLLAARLPLDAAKRF

GPNMB

11

Q14956
SSDKLLDRLLSVRPG

ANKRD55

511

Q3KP44
LPEFRLLRDTLIKQS

ANKRD61

356

A6NGH8
TLTFALRADDPLLKL

DCPS

316

Q96C86
RVKFNPLALLLDSSL

TP53BP2

921

Q13625
FSIEAILKRPARRSD

ISX

31

Q2M1V0
FLLFPRLKSISERLS

MIP

221

P30301
AVELFLKLRARDPAS

INTS6L

31

Q5JSJ4
TVKTIRFPESRLLDS

PCDHA2

136

Q9Y5H9
SLSRELLKDFPLRRV

KCNG3

21

Q8TAE7
SFLRSDLSELRVRKP

ARHGEF17

476

Q96PE2
SSLLSLKFRSEERPV

MSANTD1

191

Q6ZTZ1
KSSLLLVLFRLLEPS

ABCC10

1286

Q5T3U5
SRISFPEKELLLLIR

DCAF1

841

Q9Y4B6
RSFRSLPELKDAVLD

MINDY3

156

Q9H8M7
RSSTDPIIFLLLDKT

GPR82

301

Q96P67
TAFRATPLLRVLDLK

LRIT2

121

A6NDA9
LVSDLELLRDFPRQK

MYO15A

2286

Q9UKN7
LRRLLVFAPDKRLSA

MAPK15

281

Q8TD08
DPRLLLRTTNKSFIE

GLB1L3

181

Q8NCI6
SLNIPFETLKDRLSR

AK4

111

P27144
FLLLRERLGDSIPKS

KIF1B

1511

O60333
TLDRFPLSRLSKLRL

KCNG4

76

Q8TDN1
LRTFSLVLVLDLSKP

DYNC2LI1

106

Q8TCX1
SLIRSKLFPELEERS

PCNX3

1011

Q9H6A9
RLELKLTPSAIFDRN

PDE11A

846

Q9HCR9
SAVLFKTELEITPRR

PDZD2

2506

O15018
SILKDFDGTRARLLP

FAM222B

111

Q8WU58
ENLLSRLRFLPALKS

LRRC31

356

Q6UY01
RLSRKRALSISPLSD

GLI2

226

P10070
ALKLTLASVREREPF

NRXN1

166

Q9ULB1
RFLELESPGLSKVLR

PAQR6

171

Q6TCH4
PFELSSLSGEIRLIK

PCDHB15

291

Q9Y5E8
LSKELPARIRFLLQD

EIF4G2

286

P78344
VEPELRSFIAKRLSR

C17orf75

86

Q9HAS0
LLTLLSKFGERIPAE

DMPK

156

Q09013
LFRSTLEPVEKALRD

HSPA7

311

P48741
ELSAAALLPLLRSDK

BTBD19

171

C9JJ37
ERLSSKLTALERPFQ

CFAP119

306

A1A4V9
LSKSLSRLFDPINLV

COG5

486

Q9UP83
LLELSAEDLRTLSPR

CEFIP

1126

Q711Q0
PLSLIGSTLRFDKLD

DOCK10

1316

Q96BY6
LKTLADFDPRVSIRL

EPHA2

881

P29317
RPASLTKDRLLASTL

BCLAF1

561

Q9NYF8
FDRITTRSEKPLRSI

EIF3D

206

O15371
PASQKRLLVESLFRD

FSTL4

171

Q6MZW2
RKLDLLTITSPDNLR

AGBL4

201

Q5VU57
LALFKSLARSIPESL

GLYATL1B

11

A0A0U1RQE8
ARTLALKPTSLELFR

ELMO3

476

Q96BJ8
LSLKDRRLPELAVDT

BTBD7

881

Q9P203
RALLEAPLKQSTFTL

LTBP2

446

Q14767
LDLRRDLFEPILSKL

IP6K1

301

Q92551
RSVSLLPLEFRKDSS

IL21R

181

Q9HBE5
SSRTRSSKAILLPDL

AHCTF1

2096

Q8WYP5
LFRSTLEPVEKALRD

HSPA6

311

P17066
LINRSLPSFSEIKLR

HRH1

226

P35367
RESLIKPRLSDSETL

ERCC6L2

1311

Q5T890
STLREPLDIRSSLKD

FAM135B

646

Q49AJ0
FEILSRLLETSALPR

EFCAB3

141

Q8N7B9
SEPILQDLSRFLVKR

POLRMT

1176

O00411
RFIRPAEASLLLISK

CFAP47

1941

Q6ZTR5
LSELKSLPSEVERLR

CENPE

746

Q02224
SRFSSLLSKLLAPRV

NYX

411

Q9GZU5
SEFLSTAPRSLRKRL

ORC2

156

Q13416
LLSRLSSLKFSLPVD

RUNDC1

586

Q96C34
FERKLPVSSLTISRL

MRPS27

61

Q92552
SLSLPERDKISESLR

UTRN

2151

P46939
SSLLQPEDELFLKRL

SMYD4

41

Q8IYR2
LRKPLRSDSGSDLLR

SPATA31C2

551

B4DYI2
FLRSIPRKLLSSDLF

TAGAP

161

Q8N103
LRKPLRSDSGSDLLR

SPATA31A6

701

Q5VVP1
SDRSKVPSLELIFIR

SLC35G2

126

Q8TBE7
DRLKAIRTTLEVSPF

ITPKB

856

P27987
SRLLLDDLVPTSRLE

MRM1

36

Q6IN84
RPRFTELKAQLSTIL

PTK2

666

Q05397
LEKLRPLSLSKSIRF

PTCHD4

626

Q6ZW05
ELLTRELPSFLGKRT

S100A4

36

P26447
LFREALSKILPDLNT

URB1

496

O60287
KGLERIADLTPLLSF

SPAG17

1406

Q6Q759
LKPSTLRELERYVLS

BRD2

691

P25440
LLRRFLASVISRKPS

TXN2

6

Q99757
ELLFQSTPKLTRLDL

SLIT3

126

O75094
ASLELIKLDISRTFP

TBC1D14

461

Q9P2M4
KEESILGSIPLLSFR

PLEKHA6

96

Q9Y2H5
SSRLSFLLRDREDKL

SPEN

1401

Q96T58
RNSELLSRFKPLLDA

SOWAHA

31

Q2M3V2
LDFLRKSRVLETDPA

TIE1

926

P35590
PQLRLRVLSETLKSF

WDR97

1431

A6NE52
LLFNLSERRPDITKL

TNS1

56

Q9HBL0
SLRDEFPLLTTKRVF

TYMS

66

P04818
RSFSKVPETLLRLRA

REM2

201

Q8IYK8
LDFLRKSRVLETDPA

TEK

911

Q02763
LLPLSDARKLTFRGL

PLEC

4011

Q15149
KTLLRPERSRFDTSI

SPOCK3

231

Q9BQ16
ISKSIPIDFSFLRRL

TOPAZ1

1526

Q8N9V7
KPTLSEIELFRVFSL

SNRNP200

1006

O75643
RLPSAEETLSQKRFL

ZNF507

401

Q8TCN5
TSKRDVLSLLNLSPR

TTC28

2386

Q96AY4
IRLESRVSPKTLLTF

YTHDC2

276

Q9H6S0
LIKPLLDDFLFRASR

USP24

1591

Q9UPU5
VLLSPDERRVKLTDF

TSSK6

141

Q9BXA6
SRILTKLLLPDERAS

SLC29A4

216

Q7RTT9
VLDLKRPFLSRESLS

UQCRFS1P1

51

P0C7P4
FALTDDSKRLILFRT

WDR4

76

P57081
KLRAFLTDTLLDQLP

ZMYND10

291

O75800
ELLSIFLSVLKSTRP

USP34

2996

Q70CQ2
LSRFLPSLARSALEK

VWA8

686

A3KMH1
LASLKLTFLLRPETV

ZP2

336

Q05996
KLLPLLDRFEESSLS

TPRX2

261

P0DV77
ELDLSRPSRSISLKD

GRIN2A

1301

Q12879