Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionco-SMAD binding

USP9X USP9Y

5.63e-0512192GO:0070410
GeneOntologyMolecularFunctionpeptidase activity

TINAGL1 C1R ADAM29 USP9X USP9Y

2.95e-04654195GO:0008233
GeneOntologyMolecularFunctioncysteine-type peptidase activity

TINAGL1 USP9X USP9Y

7.57e-04192193GO:0008234
GeneOntologyMolecularFunctionmolecular sequestering activity

C1R USP9X

1.42e-0359192GO:0140313
GeneOntologyMolecularFunctionSMAD binding

USP9X USP9Y

2.99e-0386192GO:0046332
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP9X USP9Y

5.19e-03114192GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP9X USP9Y

6.10e-03124192GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP9X USP9Y

7.40e-03137192GO:0019783
GeneOntologyMolecularFunctionendopeptidase activity

C1R ADAM29 USP9X

7.44e-03430193GO:0004175
HumanPhenoAbnormal periodontium morphology

C1R USP9X

1.16e-06262HP:0410026
HumanPhenoFoveal hypopigmentation

HMCN1 CFHR3

6.93e-06462HP:0012643
HumanPhenoGeographic atrophy

HMCN1 CFHR3

2.42e-05762HP:0031609
HumanPhenoMacular hemorrhage

HMCN1 CFHR3

2.42e-05762HP:0025574
HumanPhenoMacular drusen

HMCN1 CFHR3

3.23e-05862HP:0030499
HumanPhenoAbnormality of foveal pigmentation

HMCN1 CFHR3

3.23e-05862HP:0030493
HumanPhenoYellow/white lesions of the macula

HMCN1 CFHR3

1.96e-041962HP:0030500
HumanPhenoChoroidal neovascularization

HMCN1 CFHR3

2.89e-042362HP:0011506
HumanPhenoAbnormal morphology of the choroidal vasculature

HMCN1 CFHR3

4.31e-042862HP:0025568
HumanPhenoDrusen

HMCN1 CFHR3

4.63e-042962HP:0011510
HumanPhenoFundus hemorrhage

HMCN1 CFHR3

4.96e-043062HP:0031803
HumanPhenoRetinal hemorrhage

HMCN1 CFHR3

4.96e-043062HP:0000573
MousePhenoabnormal dendritic mushroom spine morphology

CSMD3 VRK2

3.58e-0510132MP:0020512
MousePhenoabnormal pyramidal neuron dendrite morphology

CSMD3 VRK2

1.50e-0420132MP:0020337
DomainSushi

CSMD3 C1R CFHR3

1.61e-0552183PF00084
DomainCCP

CSMD3 C1R CFHR3

1.81e-0554183SM00032
DomainSUSHI

CSMD3 C1R CFHR3

2.02e-0556183PS50923
DomainSushi_SCR_CCP_dom

CSMD3 C1R CFHR3

2.13e-0557183IPR000436
DomainCUB

CSMD3 C1R

1.00e-0349182PF00431
DomainCUB

CSMD3 C1R

1.05e-0350182SM00042
Domain-

CSMD3 C1R

1.13e-03521822.60.120.290
DomainCUB

CSMD3 C1R

1.17e-0353182PS01180
DomainCUB_dom

CSMD3 C1R

1.36e-0357182IPR000859
DomainEGF_3

HMCN1 C1R ADAM29

1.40e-03235183PS50026
DomainEGF-like_dom

HMCN1 C1R ADAM29

1.65e-03249183IPR000742
DomainEGF_1

HMCN1 C1R ADAM29

1.76e-03255183PS00022
DomainUSP_CS

USP9X USP9Y

1.81e-0366182IPR018200
DomainEGF-like_CS

HMCN1 C1R ADAM29

1.88e-03261183IPR013032
DomainEGF_2

HMCN1 C1R ADAM29

1.97e-03265183PS01186
DomainUSP_1

USP9X USP9Y

2.04e-0370182PS00972
DomainUCH

USP9X USP9Y

2.10e-0371182PF00443
DomainUSP_2

USP9X USP9Y

2.10e-0371182PS00973
DomainUSP_3

USP9X USP9Y

2.15e-0372182PS50235
DomainUSP_dom

USP9X USP9Y

2.15e-0372182IPR028889
DomainPeptidase_C19_UCH

USP9X USP9Y

2.15e-0372182IPR001394
DomainEGF_CA

HMCN1 C1R

3.06e-0386182PF07645
DomainEGF_Ca-bd_CS

HMCN1 C1R

3.87e-0397182IPR018097
DomainEGF_CA

HMCN1 C1R

4.03e-0399182PS01187
DomainASX_HYDROXYL

HMCN1 C1R

4.11e-03100182PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

HMCN1 C1R

4.60e-03106182IPR000152
DomainEGF_CA

HMCN1 C1R

6.05e-03122182SM00179
DomainEGF-like_Ca-bd_dom

HMCN1 C1R

6.24e-03124182IPR001881
Pubmed

Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages.

MRC1 MUC16

2.83e-07219221331365
Pubmed

The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.

USP9X USP9Y

2.83e-0721928922996
Pubmed

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

USP9X USP9Y

2.83e-07219212925892
Pubmed

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

USP9X USP9Y

2.83e-07219212895410
Pubmed

Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.

USP9X USP9Y

1.27e-05101929384609
Pubmed

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

USP9X USP9Y

1.86e-051219223861879
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP9X USP9Y

2.96e-05151929827704
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

USP9X USP9Y

2.96e-051519214762062
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP9X USP9Y

3.83e-051719223287719
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

USP9X USP9Y

4.30e-051819212023983
Pubmed

Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.

ARHGEF16 VRK2

4.91e-046019222889411
Pubmed

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.

USP9X PTPN21

5.24e-046219231340145
Cytoband19p13.2

ZNF844 MUC16

4.01e-0322919219p13.2
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD3 C1R CFHR3

6.41e-06571231179
GeneFamilyComplement system|Sushi domain containing

C1R CFHR3

2.51e-0436122492
GeneFamilyUbiquitin specific peptidases

USP9X USP9Y

6.10e-0456122366
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

HMCN1 ZNF844 MRC1

4.74e-05168193d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

ARHGEF16 MRC1 PTPN21

5.17e-0517319342c911ed16fabdabef063830e8407192d8bde950
ToppCellNasal_Brush-Epithelial-Basal_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

TINAGL1 CSMD3 C1R

5.45e-05176193fc5787946f5a10056d326d070620575ae4081836
ToppCellNasal_Brush-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

TINAGL1 CSMD3 C1R

5.45e-051761935daaba0853afe7d20d4635169ccd4f96e735b938
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 DMKN USP9X

6.02e-051821934c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TINAGL1 HMCN1 DMKN

6.11e-05183193ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMKN C1R CFHR3

6.62e-05188193997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DMKN C1R PTPN21

6.94e-0519119344b1f62fdee03b157fe545f2ae6ff84f8929a8ac
ToppCell(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells|(1)_Control_(PBS) / Stress and Cell class

TINAGL1 HMCN1 MRC1

7.05e-05192193e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TINAGL1 CSMD3 DMKN

7.16e-05193193cd45118ced91b10baed3b1068d4673ec99824b86
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 HMCN1 MRC1

7.38e-0519519312ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DMKN C1R N4BP2L2

7.84e-05199193174f6013af6eafa577f84205a62927f2b367fda3
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

MSRA MRC1 USP9X

7.96e-05200193e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellTracheal-10x5prime-Epithelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF16 MUC16 DMKN

7.96e-05200193efd461c687155c84ef590352207e6fe4ba392a90
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HMCN1 USP9Y

4.60e-04751923167beedef7304697e9577270cdeacfc9743cee1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HMCN1 USP9Y

4.60e-047519270c346f92a9ac7e33fc1b9dee1dca0bf9ae0a38c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

HMCN1 USP9Y

4.60e-047519226d6e54ed0a6c3ff57f6269c460177bc7b8bf979
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)|Striatum / BrainAtlas - Mouse McCarroll V32

TINAGL1 ARHGEF16

9.33e-04107192d4807f008619dfd3e215d602df0d02b135b1ac37
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Striatum / BrainAtlas - Mouse McCarroll V32

TINAGL1 ARHGEF16

9.33e-041071923f24de1afbfd070f9db11c9acd02b90e5eb2511d
ToppCellStriatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-|Striatum / BrainAtlas - Mouse McCarroll V32

TINAGL1 ARHGEF16

9.33e-041071925907b9632c88d48f293c3c6d37b7ef831fbcdd86
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

N4BP2L2 USP9Y

1.19e-0312119219333a660800b583fa27b495c1f7828e6636a257
ToppCellCOVID-19_Mild-Neu_3|World / 5 Neutrophil clusters in COVID-19 patients

HMCN1 CSMD3

1.21e-031221922aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell(05)_Ciliated-(2)_48hpi|(05)_Ciliated / shred by cell type and Timepoint

MRC1 ADAM29

1.25e-03124192fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCellNS-moderate-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGEF16 MUC16

1.52e-0313719203e124901a0e85b59b6882bbafab568b50907e8b
ToppCellmoderate-Epithelial-unknown_epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ARHGEF16 MUC16

1.54e-03138192afefa8233c67aa744e939156bc538449bf6bd05b
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HMCN1 MRC1

1.57e-031391924f4b447e85dda69058d9edbcfe37e55751dd90a6
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

CSMD3 MUC16

1.57e-0313919264c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HMCN1 MRC1

1.57e-031391921cc48af58a2443db3c6798080b9c4bc70000cf87
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|367C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 MUC16

1.61e-03141192e409da87da5a38ba4d0ccc5e3f8bd89f480f9dab
ToppCellNS-critical-d_07-13-Epithelial-unknown_epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGEF16 MUC16

1.61e-0314119233ad925ff7be3c682741a6328216a89f9d4033e9
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSMD3 USP9Y

1.70e-0314519296712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Heart-RA-24m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 USP9Y

1.72e-03146192d903e091a917d3f5dcf82107e636520f75e47403
ToppCellfacs-Heart-RA-24m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 USP9Y

1.72e-031461929c9218e5257253597f2fd74fbd589b962d3078a3
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

N4BP2L2 USP9Y

1.75e-0314719294998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DMKN CPHXL2

1.80e-03149192aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CSMD3 ADAM29

1.82e-031501920205318a870e091add66ee4305747dda9f51510d
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175|Adult / Lineage, Cell type, age group and donor

HMCN1 CSMD3

1.82e-03150192b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF844 DMKN

1.84e-0315119209405a450af3ea246d9685a6d3137dfaec80e9bf
ToppCellAdult-Epithelial-basal_cell-D175|Adult / Lineage, Cell type, age group and donor

TINAGL1 ARHGEF16

1.89e-031531929ee3e7f3f19a2474283c1c79045269686f35a541
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HMCN1 CSMD3

1.89e-031531929c6fce56300ba5053efda59a438d63a808c497c0
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_4|367C / Donor, Lineage, Cell class and subclass (all cells)

CSMD3 MRC1

1.89e-031531923570dd844d6479425bf6f62129f88efa45553775
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

C1R ADAM29

1.92e-03154192dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

C1R ADAM29

1.92e-031541924bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

CSMD3 USP9Y

1.92e-031541925ff380205fa7ab97ba21f6512bc9e14c0fb320b6
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Liver / Manually curated celltypes from each tissue

DMKN RAI1

1.92e-03154192c6308074468235c88ef4ea43ab155d9f86cbf261
ToppCellfacs-Skin-nan-24m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMKN USP9Y

1.94e-03155192fa2776d258e0420b2895de1008e292ad7725dac0
ToppCellPND07-28-samps-Mesenchymal-Mesothelial-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MUC16 DMKN

1.97e-03156192605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD8-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAM29 USP9Y

1.97e-03156192b0511ce81c446482339def3a0945fcbba6da35d0
ToppCellPND07-28-samps-Mesenchymal-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MUC16 DMKN

1.97e-03156192574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCellBasal_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

TINAGL1 HMCN1

2.01e-0315819251e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCellP15-Epithelial-epithelial_progenitor_cell-epi_progenitor|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ARHGEF16 DMKN

2.04e-03159192a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCell21-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

TINAGL1 HMCN1

2.04e-031591924f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCelldroplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF16 MRC1

2.09e-03161192f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TINAGL1 HMCN1

2.09e-03161192da9eecf919866a9c579d7a707a996cf335213134
ToppCelldroplet-Lung-nan-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF16 MRC1

2.09e-03161192110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.09e-03161192a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TINAGL1 HMCN1

2.09e-03161192d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.12e-031621920bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CSMD3 USP9Y

2.12e-03162192bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

N4BP2L2 USP9Y

2.12e-03162192b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellfacs-Lung-Endomucin-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMKN PTPN21

2.12e-03162192497ae9f86a5e7946d0fde932b35719a382a6b691
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.12e-031621925799a602ef8d83925907e8e34532428be7330228
ToppCellfacs-Lung-Endomucin-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMKN PTPN21

2.12e-031621927b2949eba2b4aea239d96ed82aafab13b07624eb
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

CSMD3 ADAM29

2.14e-0316319219c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.17e-031641926a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.17e-03164192ec68954fc09b6850273b5e59caa6b09d02151097
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MSRA

2.19e-03165192b671c6a950e70f64776c2104baccb3dc2bb6a1ba
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 DMKN

2.19e-031651926d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 DMKN

2.19e-0316519284f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TINAGL1 HMCN1

2.19e-031651928a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCelldroplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 VRK2

2.22e-03166192de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-ectodermal/neuroectodermal-like_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

TINAGL1 MUC16

2.22e-03166192d7e49416426a62801ea1062d7aaf55ea622ae118
ToppCelldroplet-Marrow-BM-30m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MSRA

2.22e-03166192019d365df44c3bbd88c1f4bdceb3de0ff76d3e8d
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CSMD3 DMKN

2.22e-031661923b67064a5149e72f895344d938c64b8ff65247f5
ToppCellControl-Epithelial-Mesothelial|Control / Disease state, Lineage and Cell class

MUC16 C1R

2.22e-031661921ed3788257e14f097862b999f020bfe2a57de52b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TINAGL1 HMCN1

2.22e-0316619227af6c906cff1d40d134f0386db7708869691121
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 CFHR3

2.25e-0316719231633899aae852873a4887e72c621474b0a51a33
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 MRC1

2.25e-03167192b93103a868fba63a8910bffb690a6242b9252833
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DMKN USP9Y

2.25e-03167192dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF844 MRC1

2.25e-03167192881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCelldroplet-Spleen-nan-21m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MSRA

2.25e-03167192cfcd72292c733cdb18c92fdb61b68f6806d22c8c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HMCN1 CSMD3

2.25e-031671921c1b4722c6c0eff85a9b32ca7b4e281caebf63b0
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGEF16 MUC16

2.25e-03167192720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 MRC1

2.25e-0316719226cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 MRC1

2.25e-03167192fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMCN1 MRC1

2.25e-03167192f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TINAGL1 MRC1

2.27e-0316819263437b3c3a66f953eaed600965ab193f9cc49da2
ToppCelldroplet-Fat-Scat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 DMKN

2.27e-0316819202dfe8037e61f9d4ac5f8df3929673bc212fd2cd
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 HMCN1

2.27e-031681923bddf411a60137a8883fc9e77586e4719b0d6067
ToppCelldroplet-Fat-Scat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 DMKN

2.27e-0316819294916feefd413c84bb7d3fd2d3e403036b705b69
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 HMCN1

2.27e-03168192b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 DMKN

2.27e-0316819229a6c3ba69e03ccb19efb8ac177b9a162dc1ea43
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 DMKN

2.27e-031681924297be958a4754677df7cf73feba19b0d76f1b4a
ToppCelldroplet-Spleen-SPLEEN-30m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MSRA

2.27e-03168192c0ff30e2c47005514131a0866cf10a1c228128fc
ToppCellfacs-Lung-Endomucin-24m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 HMCN1

2.30e-03169192d2862a7ddee6d7a65d84ef9d0800ba6f4690973f
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HMCN1 MRC1

2.30e-03169192d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 HMCN1

2.30e-031691928dba7546adc6b1345933eec81fc77fc9611fae60
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CSMD3 DMKN

2.33e-03170192a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCelldroplet-Fat-Scat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 DMKN

2.33e-03170192de722bea7527d6ad11b69f8e9589638f52854beb
ToppCelldroplet-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 DMKN

2.33e-03170192dbd6c9c7be824a1ff1b31af791064127cafbd194
Diseaseage related macular degeneration 1 (is_implicated_in)

HMCN1 CFHR3

2.11e-064182DOID:0110014 (is_implicated_in)
DiseaseMACULAR DEGENERATION, AGE-RELATED, 1

HMCN1 CFHR3

2.11e-064182603075
DiseaseMacular Degeneration, Age-Related, 1

HMCN1 CFHR3

2.11e-064182C1864205
DiseaseAge related macular degeneration 1

HMCN1 CFHR3

2.11e-064182cv:C1864205
DiseaseAge-related macular degeneration

HMCN1 CFHR3

5.35e-0518182cv:C0242383
DiseaseAge related macular degeneration

HMCN1 CFHR3

1.51e-0430182C0242383
DiseaseComplement deficiency disease

C1R CFHR3

1.84e-0433182C0272242
DiseaseTourette syndrome

CSMD3 MUC16

4.23e-0450182EFO_0004895
Diseasetestosterone measurement

HMCN1 CSMD3 VRK2 RAI1 PTPN21

7.99e-041275185EFO_0004908
Diseaseirritability measurement

MSRA VRK2

1.13e-0382182EFO_0009594
DiseaseTinnitus, wellbeing measurement

ADAM29 PTPN21

1.55e-0396182EFO_0007869, HP_0000360
DiseaseSchizophrenia

MSRA VRK2 RAI1 PTPN21

1.74e-03883184C0036341
DiseaseDrug Use Disorders

MSRA CSMD3

2.21e-03115182C0013222
DiseaseDrug Dependence

MSRA CSMD3

2.21e-03115182C1510472
DiseaseDrug habituation

MSRA CSMD3

2.21e-03115182C0013170
DiseaseSubstance Dependence

MSRA CSMD3

2.21e-03115182C0038580
DiseaseSubstance Use Disorders

MSRA CSMD3

2.21e-03115182C0038586
DiseaseSubstance-Related Disorders

MSRA CSMD3

2.21e-03115182C0236969
DiseaseDrug abuse

MSRA CSMD3

2.21e-03115182C0013146
DiseaseOrganic Mental Disorders, Substance-Induced

MSRA CSMD3

2.21e-03115182C0029231
DiseasePrescription Drug Abuse

MSRA CSMD3

2.21e-03115182C4316881
DiseaseSubstance abuse problem

MSRA CSMD3

2.25e-03116182C0740858
Diseaseinsomnia measurement

MSRA CSMD3 VRK2

2.32e-03443183EFO_0007876
Diseaseblood nickel measurement

MUC16 DMKN

2.40e-03120182EFO_0007583
Diseasemood instability measurement

MSRA VRK2

2.73e-03128182EFO_0008475
Diseaseascending aortic diameter

HMCN1 MSRA

3.25e-03140182EFO_0021787
Diseaseneuroimaging measurement

MRC1 VRK2 RAI1 PTPN21

3.49e-031069184EFO_0004346

Protein segments in the cluster

PeptideGeneStartEntry
EDQPFVQNNCYYHGY

ADAM29

91

Q9UKF5
VQNNCYYHGYVEGDP

ADAM29

96

Q9UKF5
NYPLNYENNHECIYS

CSMD3

1256

Q7Z407
FHPYIAYCSNEVYQQ

ARHGEF16

371

Q5VV41
QQVHCPYDQLQIYAN

C1R

246

P00736
YQHYGQQGQGYCQPD

RAI1

311

Q7Z5J4
DYHQQYLSKNPNGYC

MSRA

206

Q9UJ68
EYNVQQQCPGYYQSH

MUC16

14486

Q8WXI7
NYQPQQHYRQYSHLY

HMCN1

5381

Q96RW7
NLFVPNQNGYYCHSQ

PTPN21

361

Q16825
EYQCQPYYELQGSNY

CFHR3

236

Q02985
RDDQNYNYNQHAYPT

DMKN

426

Q6E0U4
QYHPQQHQQPQNYSE

CPHXL2

286

A0A1W2PPK0
YGEPNNYQNVEYCGE

MRC1

741

P22897
QYQQNNHVHGQPYTG

USP9X

2506

Q93008
HCPNSYVNNNDIYQV

TINAGL1

326

Q9GZM7
SQYQQNNHVHGQPYT

USP9Y

2506

O00507
SEYQEYGQEPYKCQQ

ZNF844

131

Q08AG5
YRYCPNGNHKQYQEN

VRK2

191

Q86Y07
SQIQNGYYVNNCHVN

N4BP2L2

311

Q92802