Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B PRMT5

2.99e-08311226GO:0008327
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD2 RGPD3

2.35e-04201223GO:0061665
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD2 FKBP15 RGPD3

2.46e-04501224GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD2 FKBP15 RGPD3

3.08e-04531224GO:0016859
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 RGPD2 ARHGAP40 TBC1D30 RGS12 RGS6 SIPA1L1 RGPD3

3.20e-042791228GO:0005096
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B TASOR

1.82e-07441186GO:0006346
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B TASOR

7.11e-07551186GO:0140718
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD2 RGPD3

1.50e-0591183GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD2 RGPD3

2.13e-05101183GO:1903301
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

MBD3L5 MBD3L2 SMCHD1 MBD3L3 MBD3L4 MBD3L2B PRMT5 TASOR

2.22e-052031188GO:0045814
GeneOntologyBiologicalProcessheterochromatin formation

MBD3L5 MBD3L2 SMCHD1 MBD3L3 MBD3L4 MBD3L2B TASOR

4.28e-051631187GO:0031507
GeneOntologyBiologicalProcessgluconeogenesis

RGPD4 RGPD2 GCK DGAT2 RGPD3 SLC25A11

4.28e-051111186GO:0006094
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD2 RGPD3

5.01e-05131183GO:0033131
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD4 RGPD2 GCK DGAT2 RGPD3 SLC25A11

5.23e-051151186GO:0019319
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD4 RGPD2 GCK DGAT2 RGPD3

5.42e-05711185GO:0006111
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD2 RGPD3

6.35e-05141183GO:1903299
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD4 RGPD2 GCK DGAT2 RGPD3 SLC25A11

6.94e-051211186GO:0046364
GeneOntologyBiologicalProcessprotein-DNA complex organization

MBD3L5 MBTD1 MED16 MBD3L2 SMCHD1 CHAF1A ASH1L MED14 MBD3L3 MBD3L4 MBD3L2B PRMT5 SYCP1 HCFC2 TASOR RAD54L

1.82e-0499911816GO:0071824
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD2 RGPD3

1.94e-04201183GO:0006607
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD2 RGPD3

1.09e-0581233GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD2 RGPD3

2.31e-05101233GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD2 RGPD3

6.90e-05141233GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD2 RGPD3

1.52e-04181233GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD2 RGPD3

2.11e-04201233GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD2 RGPD3

2.45e-04211233GO:0106068
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L2 MBD3L3 MBD3L4

5.05e-0871174IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L2 MBD3L3 MBD3L4

5.05e-0871174IPR032343
DomainMBDa

MBD3L5 MBD3L2 MBD3L3 MBD3L4

5.05e-0871174PF16564
DomainMBD_C

MBD3L5 MBD3L2 MBD3L3 MBD3L4

5.05e-0871174PF14048
DomainRab_bind

RGPD4 RGPD2 RGPD3

8.23e-0671173PF16704
DomainGCC2_Rab_bind

RGPD4 RGPD2 RGPD3

8.23e-0671173IPR032023
Domain-

RGPD4 RGPD2 RGPD3

2.78e-051011731.10.220.60
DomainGrip

RGPD4 RGPD2 RGPD3

3.81e-05111173SM00755
DomainGRIP

RGPD4 RGPD2 RGPD3

3.81e-05111173PF01465
DomainRan_BP1

RGPD4 RGPD2 RGPD3

5.06e-05121173PF00638
DomainRANBD1

RGPD4 RGPD2 RGPD3

5.06e-05121173PS50196
DomainGRIP_dom

RGPD4 RGPD2 RGPD3

5.06e-05121173IPR000237
DomainGRIP

RGPD4 RGPD2 RGPD3

5.06e-05121173PS50913
DomainRanBD

RGPD4 RGPD2 RGPD3

6.55e-05131173SM00160
DomainRan_bind_dom

RGPD4 RGPD2 RGPD3

6.55e-05131173IPR000156
DomainDUF4592

KIAA1210 CRACDL

1.16e-0431172IPR028030
DomainDUF4592

KIAA1210 CRACDL

1.16e-0431172PF15262
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

3.18e-126124512504854
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

3.18e-126124518942147
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

1.55e-0915124515701600
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD2 RGPD3

1.53e-06712439037092
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD2 RGPD3

1.53e-067124315710750
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD2 RGPD3

1.53e-067124311353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD2 RGPD3

1.53e-067124330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD2 RGPD3

1.53e-067124338838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD2 RGPD3

1.53e-06712437559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD2 RGPD3

1.53e-067124317372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD2 RGPD3

1.53e-067124338657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD2 RGPD3

1.53e-067124321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD2 RGPD3

1.53e-067124318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD2 RGPD3

1.53e-067124325187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD2 RGPD3

1.53e-06712438603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD2 RGPD3

1.53e-067124326632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD2 RGPD3

1.53e-067124324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD2 RGPD3

1.53e-067124323818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD2 RGPD3

1.53e-067124323536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD2 RGPD3

1.53e-067124312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD2 RGPD3

1.53e-067124322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD2 RGPD3

1.53e-067124320682751
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD2 RGPD3

2.45e-068124321670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD2 RGPD3

2.45e-068124327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD2 RGPD3

2.45e-068124321310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD2 RGPD3

2.45e-068124322262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD2 RGPD3

2.45e-068124328745977
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD2 RGPD3

3.66e-069124318394993
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD2 RGPD3

3.66e-069124328100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD2 RGPD3

3.66e-069124317887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD2 RGPD3

3.66e-069124311553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD2 RGPD3

3.66e-069124310601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD2 RGPD3

3.66e-06912439733766
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD2 RGPD3

3.66e-069124328877029
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD2 RGPD3

5.21e-0610124327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD2 RGPD3

5.21e-0610124316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD2 RGPD3

5.21e-061012438857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD2 RGPD3

5.21e-0610124321859863
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PCNP SHROOM3 TRIM25 TBC1D30 DCTN5 MED16 CHAF1A RPP30 MED14 ITPRID2 ZNF385A PRMT5 CRACDL SIPA1L1 RGPD3 SLC25A11 HCFC2 TASOR

6.26e-0614971241831527615
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD2 RGPD3

7.15e-0611124317069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD2 RGPD3

7.15e-0611124335771867
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD2 RGPD3

7.15e-0611124334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD2 RGPD3

1.23e-0513124331427429
Pubmed

Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells.

IL10RA STAT3

1.26e-052124227866206
Pubmed

PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth.

STAT3 PRMT5

1.26e-052124238760429
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RGPD4 RGPD2 CLTCL1 PCDHGA2 SMCHD1 CHAF1A ASH1L APOB CREBRF DGAT2 RGPD3 SYCP1 UGP2 NAV2 MYH15 TASOR CAVIN2

1.50e-0514421241735575683
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD2 RGPD3

1.95e-0515124314697343
Pubmed

Dual role of Fam208a during zygotic cleavage and early embryonic development.

HCFC2 TASOR CNTN1

2.39e-0516124334216590
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD2 IGF2BP3 RGPD3 CAVIN2

2.91e-0599124527746211
Pubmed

Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.

IL13RA1 STAT3

3.77e-053124232355002
Pubmed

A Three Protein-Coding Gene Prognostic Model Predicts Overall Survival in Bladder Cancer Patients.

GALR1 SMCHD1

3.77e-053124233150179
Pubmed

Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma.

TRIM14 STAT3

3.77e-053124231668806
Pubmed

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.

HLA-DMA LCP2

3.77e-053124222623329
Pubmed

Whole exome sequencing identifies three novel gene mutations in patients with the triad of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis.

CLIP2 APOB

3.77e-053124232734598
Pubmed

PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.

STAT3 PRMT5

3.77e-053124234026434
Pubmed

TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1α Pathway.

TRIM14 STAT3

3.77e-053124237628777
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

HSP90B2P SMCHD1 WASHC1 RPP30 MADD PRMT5 SIPA1L1 SLC25A11 CAVIN2

5.44e-05475124931040226
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD2 RGPD3

6.48e-0522124327717094
Pubmed

Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.

IL10RA STAT3

7.53e-054124227268052
Pubmed

UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1.

UBE2O CAVIN2

7.53e-054124236443833
Pubmed

Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex.

LIG1 RAD9A

7.53e-054124216731526
Pubmed

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.

IL10RA STAT3

7.53e-054124223166328
Pubmed

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice.

APOB DGAT2

7.53e-054124218252207
Pubmed

The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.

LIG1 RAD9A

7.53e-054124215871698
Pubmed

A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.

MRPL37 NUDT12 UBE2O

8.48e-0524124325240745
Pubmed

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.

STAT3 PRMT5

1.25e-045124221159818
Pubmed

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

LIG1 RAD9A

1.25e-045124219523882
Pubmed

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.

IL10RA STAT3

1.25e-045124226962683
Pubmed

Homozygous MED25 mutation implicated in eye-intellectual disability syndrome.

MED16 MED14

1.25e-045124225792360
Pubmed

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.

RHCE USP2 NAV2

1.51e-0429124316966370
Pubmed

USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.

RTEL1 USP2

1.87e-046124236567903
Pubmed

Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.

RGS12 RGS6

1.87e-046124226987813
Pubmed

Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.

USP2 UBE2O

1.87e-046124224703950
Pubmed

Meiotic functions of RAD18.

SYCP1 RAD54L

1.87e-046124221807948
Pubmed

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.

IL10RA STAT3

1.87e-046124234879221
Pubmed

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.

IL10RA STAT3

1.87e-046124231552035
Pubmed

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.

TRIM25 IGF2BP3

1.87e-046124233436560
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

RGPD4 RGPD2 ITPRID2 SH3BP4 RGPD3 OSR1 WDFY3 CAVIN2

1.95e-04442124815815621
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

TRIM25 CHAF1A LIG1 IGF2BP3 SLC25A11

2.08e-04150124530154076
Pubmed

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.

MED16 CHAF1A MED14

2.23e-0433124333567268
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD4 RGPD2 CHAF1A LIG1 RGPD3

2.28e-04153124526365490
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

ASH1L DISP3 NAV2 ZNF624 CEP126

2.28e-04153124510718198
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

SHROOM3 TRIM25 ABL2 APRT BIN3 RGS12 STAT3 MTMR6 PRMT5 SIPA1L1 SLC25A11

2.48e-048531241128718761
Pubmed

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

ATP13A4 KCNH7 MADD PARP6

2.49e-0485124423055939
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD2 SMCHD1 RGPD3

2.61e-0486124437253089
Pubmed

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation.

IL10RA STAT3

2.62e-047124236446385
Pubmed

Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung.

IL10RA STAT3

2.62e-047124232399548
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD2 RGPD3

3.41e-0438124312791264
Pubmed

An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.

SMCHD1 TASOR

3.48e-048124215890782
Pubmed

A human MAP kinase interactome.

ABL2 CLIP2 CHAF1A ITPRID2 LCP2 MADD SH3BP4 NAV2

3.67e-04486124820936779
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

RGPD4 RGPD2 SMCHD1 STAT3 IGF2BP3 SIPA1L1 RGPD3

3.78e-04370124722922362
Pubmed

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

NUDT12 USP2

4.47e-049124231875550
Pubmed

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

MED16 MED14

4.47e-049124214636573
Pubmed

Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.

FKBP15 WASHC1

4.47e-049124224819384
Pubmed

TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.

MED16 MED14

4.47e-049124212101254
Pubmed

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

MED16 MED14

4.47e-04912428710870
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

TRIM25 MED16 SMCHD1 CHAF1A MED14 ELAC2 IGF2BP3 UBE2O NFATC2IP

5.26e-04645124925281560
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

TRIM25 MED16 SMCHD1 MED14 PRMT5 RAD54L

5.31e-04281124624163370
Pubmed

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

WASHC1 UBE2O

5.57e-0410124223452853
Pubmed

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.

MED16 MED14

5.57e-0410124212218053
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 SH3BP4 TMEM132D RP1

1.40e-0619812471408e02e053ad3406229bfe8189da03be6366e81
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHAF1A C3orf49 LIG1 SAMD3 RAD54L CNTN1

5.61e-06159124695128a2367ff2a639b21913c0350924c174faef8
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 TMEM132D RP1

5.61e-0615912468680b054622f573a82b1625fb93c2d5db81d1034
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 SHROOM3 ARHGAP40 TMEM132D NAV2 RP1

6.24e-0616212465c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCelldroplet-Marrow-nan-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DMA CLIP2 ZNF385A PLBD2 UBE2O DNAH17

9.09e-0617312466d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCellSevere_COVID-19-Myeloid-Neutrophil|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

TRIM25 SMCHD1 LCP2 SCARF1 CREBRF DNAH17

1.04e-051771246a6fae376f1beb1df423484d9b1bd1d954ca117af
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 NAV2 RP1

1.18e-051811246c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CPAMD8 SHROOM3 ARHGAP40 SH3BP4 RP1 CNTN1

1.21e-051821246215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic|GI_small-bowel / Manually curated celltypes from each tissue

BCL2L14 HLA-DMA ZNF385A SH3BP4 SCARF1 DGAT2

1.25e-0518312466109199cf25b28831193a5ed7925b5bf38c6eb43
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 TMEM132D RP1

1.29e-051841246102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 TMEM132D RP1

1.33e-05185124698b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SHROOM3 TBC1D30 SH3BP4 MAPKBP1 VPS13B CAVIN2

1.37e-05186124677bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SHROOM3 TBC1D30 SH3BP4 MAPKBP1 VPS13B CAVIN2

1.37e-05186124613bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 NAV2 RP1

1.69e-0519312462bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BCL2L14 ATP13A4 SHROOM3 FMO3 EML5 NAV2

1.90e-051971246b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 SH3BP4 RP1

1.95e-051981246af399569c718f5fd971d73a7926768c9311002a3
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 SHROOM3 SIPA1L1 NAV2 WDFY3 VPS13B

1.95e-0519812461996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellfacs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL10RA KCNH7 TRIM25 LCP2 DISP3

6.71e-051521245931c10245cde9b3290224cc1da46b2bf300b9ac2
ToppCell367C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FMO3 WDR64 NUDT12 USP2 NAV2

7.82e-051571245f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 PTCHD4 CCDC7 SYCP1 MYH15

8.55e-051601245c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 PTCHD4 CCDC7 SYCP1 MYH15

8.55e-05160124525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SQLE APOB GCK DGAT2 ENTPD5

9.89e-051651245d449a568664a81d9b5538e8f409301448a32ac37
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA BCL2L14 PYY DNAH17 UGP2

1.02e-041661245a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCellfacs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA BCL2L14 PYY DNAH17 UGP2

1.02e-0416612450f641302a6b71c4badaaf20f51162bfc2386b167
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

1.14e-041701245a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHROOM3 HEATR4 TTC21A USP2 CRACDL

1.17e-0417112451854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-0417312455b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-041731245bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-041731245a6e73a40b0d5356564a594053e772f9d061a5919
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-041731245a8b5370f4c893a20c58e97659f3ac168699693f8
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-0417312451edef5aeab626cbf2c09468e77b02cfa2d21ba03
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRIM25 SMCHD1 LCP2 SCARF1 DNAH17

1.23e-041731245c37dba3804df7c3151e18e6ae4e0b6e7a92bae97
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOB ITPRID2 SLC13A1 DGAT2 ENTPD5

1.27e-0417412452fbdb62e269acf4447b171700a615e878dde7f9f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOB ITPRID2 SLC13A1 DGAT2 ENTPD5

1.27e-0417412457c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

ATP13A4 SHROOM3 TMEM132D NAV2 RP1

1.27e-041741245548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellCOVID-matDC-|COVID / Condition, Cell_class and T cell subcluster

BCL2L14 FMO3 OSR1 NAV2 CAVIN2

1.30e-041751245db5e170411dfa62074c4b8311bb8c589d1c4279b
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FMO3 TRIM14 SLC13A1 DGAT2 ANKRD34C

1.30e-0417512450992de1c7bffcb6890584357a7a0a8955927da6c
ToppCellCOVID-matDC|COVID / Condition, Cell_class and T cell subcluster

BCL2L14 FMO3 OSR1 NAV2 CAVIN2

1.30e-041751245e2b638109c9ffd10430e6e134035622b7605ce23
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BCL2L14 IL13RA1 HLA-DMA ZNF385A DGAT2

1.34e-0417612457d1e2627d7ec5ddd6c87c55d2a6879255b76949e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

1.34e-0417612453fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP13A4 RGS12 TMEM132D DNAH17 WDFY3

1.34e-041761245327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

1.41e-041781245f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

BCL2L14 TRIM25 SMCHD1 TTC21A TRIM14

1.45e-041791245af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 SHROOM3 RGS6 NAV2 RP1

1.45e-0417912454f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

BCL2L14 HLA-DMA SCARF1 DGAT2 MYH15

1.45e-04179124599894067e2c2a3ed53abdc5434410c3172693496
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FKBP15 ZNF385A SIPA1L1 CEP126 CAVIN2

1.49e-04180124562511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

FMO3 CLTCL1 COL6A6 PTCHD4 NAV2

1.49e-041801245137fc14859c89e1ecd98bee388bb58c04b835847
ToppCellmild_COVID-19_(asymptomatic)-cDC|World / disease group, cell group and cell class (v2)

IL13RA1 HLA-DMA ZNF385A RGS12 SH3BP4

1.49e-04180124568d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

FMO3 CLTCL1 COL6A6 PTCHD4 NAV2

1.49e-041801245cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell390C-Myeloid-Dendritic-cDC1|390C / Donor, Lineage, Cell class and subclass (all cells)

BCL2L14 HLA-DMA ZNF385A SCARF1 DGAT2

1.52e-041811245d1c69171600b2d2aec96fa86fa757b588c265f7c
ToppCellwk_20-22-Hematologic-Myeloid-aDC_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BCL2L14 IL13RA1 HLA-DMA ZNF385A DGAT2

1.52e-0418112458f7e5c310f4cdc4b2fb54fea950d01e56bd298e1
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCARF1 CRACDL DNAH17 RP1 CAVIN2

1.56e-04182124563b41b538b26bc899558807fd035e543611f8c52
ToppCelldroplet-Tongue-nan-24m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SQLE ITPRID2 DGAT2 ENTPD5 ALOX12B

1.60e-0418312459e6c96ada930e8559246a270dfc69fb3cbb3bdf3
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 APOB DISP3 MYH15 CNTN1

1.65e-0418412452cbed6462fea2622871bb7e49b0df3d984239281
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

BCL2L14 HLA-DMA SH3BP4 SCARF1 DGAT2

1.65e-0418412458e393eea7240584a3cef718bee094e2705ec1891
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 SHROOM3 TMEM132D CRACDL NAV2

1.65e-04184124529c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 APOB DISP3 MYH15 CNTN1

1.65e-041841245ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 APOB DISP3 MYH15 CNTN1

1.65e-0418412452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MBTD1 RHCE IGF2BP3 BBS12 CAVIN2

1.69e-041851245709236097cbfc254796fcc69b5f5178b73dad9bd
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MBTD1 RHCE IGF2BP3 BBS12 CAVIN2

1.69e-041851245af078a6c4a3e0b54b7d8ab7b30dcd06053ebfd28
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BCL2L14 ATP13A4 SHROOM3 EML5 CAVIN2

1.69e-0418512450c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 TMEM132D RP1

1.73e-0418612452ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell10x5'-Liver-Myeloid_Dendritic-DC1|Liver / Manually curated celltypes from each tissue

BCL2L14 HLA-DMA SH3BP4 SCARF1 MYH15

1.73e-041861245e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

1.77e-04187124581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

ATP13A4 SHROOM3 TBC1D30 MAPKBP1 CAVIN2

1.77e-041871245b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ATP13A4 SHROOM3 TBC1D30 MAPKBP1 CAVIN2

1.77e-04187124561c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TRIM25 ITPRID2 PLBD2 RGS12 PARP6

1.82e-0418812452c4e791df69a9df29922f9117e5cac7787c129ce
ToppCelldroplet-Marrow-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHAF1A LIG1 DGAT2 ENTPD5 UGP2

1.82e-0418812451526e271411e381eae7a342003002276f83f47a3
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TRIM25 ITPRID2 PLBD2 RGS12 PARP6

1.82e-041881245b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCellP07-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IL13RA1 SHROOM3 MYOM1 COL6A6 OSR1

1.82e-0418812456ec22b79b19d57ea187f312907819dc2d01f3efe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 SH3BP4 RGS6 NAV2 RP1

1.91e-041901245bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 SH3BP4 RGS6 NAV2 RP1

1.91e-041901245b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

1.96e-04191124523776c7302cead3881b39127398f3b3e0d27885e
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IL13RA1 ZNF385A SH3BP4 SCARF1 CAVIN2

2.01e-041921245e24a8856ef01ccf69a5e968bd409f9b84befa91e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TTC21A CRACDL RP1 CEP126 CCDC33

2.05e-041931245ea345d34440b25f65358a53dc72831998d1c3620
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SHROOM3 ARHGAP40 NAV2 CAVIN2

2.10e-0419412455b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CHAF1A KIAA1210 LIG1 NAV2 RAD54L

2.10e-041941245590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SHROOM3 ARHGAP40 NAV2 CAVIN2

2.10e-041941245ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SHROOM3 ARHGAP40 NAV2 CAVIN2

2.10e-0419412458c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP13A4 SHROOM3 ARHGAP40 NAV2 CAVIN2

2.10e-0419412456e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell10x5'-Liver-Myeloid_Dendritic|Liver / Manually curated celltypes from each tissue

IL13RA1 HLA-DMA ZNF385A SH3BP4 MYH15

2.10e-041941245e6391bc7073831847c469ef0b0c437118e1f151f
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

SHROOM3 CRACDL NAV2 RP1 CEP126

2.15e-041951245fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell(3)_DC_2|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IL13RA1 ABL2 HLA-DMA GCK ZNF385A

2.15e-0419512453d656e13f1440a3624fe890f59343f7313b51740
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 CPAMD8 SHROOM3 ARHGAP40 RP1

2.15e-041951245dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

SHROOM3 CRACDL NAV2 RP1 CEP126

2.15e-041951245eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

TTC21A USP2 RP1 CEP126 CCDC33

2.15e-04195124560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 SHROOM3 SIPA1L1 NAV2 VPS13B

2.21e-041961245ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

BCL2L14 SMCHD1 TTC21A TRIM14 CREBRF

2.21e-041961245daa1c3322d81e649161e889e1d78451d2d425d09
ToppCell390C-Myeloid-Dendritic-cDC2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

IL13RA1 ABL2 HLA-DMA CHAF1A ZNF385A

2.21e-041961245799f54131fb1034f82ef4872cfb2c64359541086
ToppCellMild-CD4+_T_activated|World / Disease group and Cell class

BCL2L14 SMCHD1 TTC21A TRIM14 CREBRF

2.21e-041961245417b4fc2e4388f34c410576131b02936f93e46b6
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

SHROOM3 CRACDL NAV2 RP1 CEP126

2.21e-04196124587d9881cfec461a5d89b688a83749b618c519485
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ARHGAP40 COL6A6 SMCHD1 LCP2 DGAT2

2.26e-041971245d2b2eaa6f7294ff56b84a69c8727c7e0f9fd0466
ToppCellcritical-Myeloid-Neutrophil|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SMCHD1 LCP2 SCARF1 CREBRF DGAT2

2.26e-041971245f1248781e71e3a158d06e9ec93eb90dc6d48bcb2
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 SHROOM3 ARHGAP40 TBC1D30 NAV2

2.31e-0419812455fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

TTC21A EML5 RP1 CEP126 CCDC33

2.31e-0419812456d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellSigmoid-(5)_Dendritic_cell-(50)_cDC2|Sigmoid / shred on region, Cell_type, and subtype

IL13RA1 HLA-DMA ZNF385A RGS12 SCARF1

2.37e-041991245402af84db90d8a49d67cf44c24766aefb00fd716
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TTC21A RP1 CEP126 ALOX12B CCDC33

2.37e-04199124515f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellSigmoid-Dendritic_cell-cDC2|Sigmoid / Region, Cell class and subclass

IL13RA1 HLA-DMA ZNF385A RGS12 SCARF1

2.37e-041991245cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TTC21A RP1 CEP126 ALOX12B CCDC33

2.42e-04200124596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellTransverse-(5)_Dendritic_cell-(50)_cDC2|Transverse / shred on region, Cell_type, and subtype

IL13RA1 HLA-DMA ZNF385A RGS12 SCARF1

2.42e-042001245eea523f7512b54d7443651bce3ff6d043a9897aa
Drug5-(tetradecyloxy)-2-furoic acid

APOB GCK LCT CRAT

1.06e-06151234CID000115175
Diseaseyang deficiency

RGS6 SIPA1L1

1.56e-0521172EFO_0006817
DiseaseDIABETES MELLITUS, PERMANENT NEONATAL

GCK STAT3

3.23e-0471172C1833104
Diseaseillegal drug consumption

WDR64 TMEM132D

1.18e-03131172EFO_0005431
Diseaseinherited metabolic disorder (is_implicated_in)

FMO3 LIG1

1.58e-03151172DOID:655 (is_implicated_in)
Diseasetriglycerides to total lipids in large HDL percentage

APOB RGS12 MADD

1.76e-03601173EFO_0022330
Diseaseheart rate

SLC10A7 RGS6 SLC13A1 TMEM132D SIPA1L1

2.07e-032251175EFO_0004326
Diseaseblood metabolite measurement

CRAT SARDH

2.55e-03191172EFO_0005664
DiseaseUsual Interstitial Pneumonia

RTEL1 STAT3

2.55e-03191172C4721509
DiseaseHamman-Rich Disease

RTEL1 STAT3

2.55e-03191172C4721508
Diseasepantothenic acid mesurement

RTEL1 TMEM132D

2.83e-03201172EFO_0010519
DiseaseFamilial Idiopathic Pulmonary Fibrosis

RTEL1 STAT3

2.83e-03201172C4721952
Diseaseectonucleoside triphosphate diphosphohydrolase 5 measurement

HEATR4 ENTPD5

3.12e-03211172EFO_0008115
DiseaseIdiopathic Pulmonary Fibrosis

RTEL1 STAT3

3.12e-03211172C1800706
DiseaseSarcosine measurement

PCDHGA2 SARDH

3.73e-03231172EFO_0021668

Protein segments in the cluster

PeptideGeneStartEntry
TFGGPLLKTKRPVIS

ZNF385A

61

Q96PM9
AKGQSTPRLFSIKPF

AKAP2

341

Q9Y2D5
KAVKFPTPLRPFVTR

ADCK2

381

Q7Z695
SFKQGLSVSPFPKKR

ASH1L

876

Q9NR48
KVPKARLSATFGFNP

DISP3

976

Q9P2K9
VIKSISDISFPKRGP

ANKRD34C

281

P0C6C1
TLTRSKFIFTLPKGF

CCDC33

91

Q8N5R6
FTRSITPSKFPTKVI

CCDC7

1276

Q96M83
SGITGFFTPRLIKKT

ABL2

746

P42684
TVALVFSKGKPFRQP

ATP13A4

1051

Q4VNC1
SFPGKKITSRAAAPV

CREBRF

171

Q8IUR6
FKSTPALFSPKLLRT

BCL2L14

36

Q9BZR8
ARTVVKPLGFLKPFS

CRAT

6

P43155
IRIGFPSTSPAKAKK

CLIP2

286

Q9UDT6
PFPTSTPLRRITKKF

CHAF1A

311

Q13111
GRTFLGPLKSSKFII

BBS12

26

Q6ZW61
SLKGREKLAPVPFFS

APRT

161

P07741
KRDGPDTLLSKTFFP

PYY

66

P10082
KISETTTPGFRIPLK

PCDHGA2

141

Q9Y5H1
EAFIRSILSKPFKVP

RAD54L

71

Q92698
PPPKKFRSLFFGSIL

RAD9A

356

Q99638
TGGVPIRTVKSFLSK

RGS6

41

P49758
HKKLPLGFTFSFPVR

GCK

141

P35557
ERKKPPFGAISSSVL

SLC10A7

196

Q0GE19
KSILFVPTFVPRGLF

HSP90B2P

41

Q58FF3
IFRKSPFLVPKGSVS

ENTPD5

151

O75356
ILFKGVFPPLLEKST

FMO3

351

P31513
IGPFSKISEFKTCIP

HCFC2

661

Q9Y5Z7
LTLPTKGAREKATPF

MADD

866

Q8WXG6
KATPFPSLKVFGLNT

MADD

876

Q8WXG6
SLKFIPGKPVLETRT

NFU1

71

Q9UMS0
KRLTGAKTLPPDFSQ

MBTD1

261

Q05BQ5
PRIASKPIIVGSSKF

MTMR6

166

Q9Y217
PILPIKTVNRKFFGF

KCNH7

146

Q9NS40
FTSFPSPPVLGKLKR

MBD3L5

6

A6NJ08
LPTKPTKISKFGFAI

PCNP

61

Q8WW12
KKPTTSRVGFVLPSA

KRT222

161

Q8N1A0
VSIDTFNKSPPKRGL

KPTN

81

Q9Y664
IPFKSGEPALRTKSN

FKBP15

331

Q5T1M5
FTSFPSLPVLGKLKR

MBD3L2B

6

A0A1B0GVZ6
KVRAFTFPSEVPSKA

LCT

866

P09848
LFKKPSPFIFISQRP

IL10RA

271

Q13651
SPTVKALFGKTRVSP

PCOTH

21

Q58A44
VGPVGFKPETFRKFL

MRPL37

401

Q9BZE1
KKVFRASVALTPTAP

ITPRID2

1146

P28290
FVRSKSFLITPVKPA

CRACDL

876

Q6NV74
IFKDAKIPVSGPFLV

IGF2BP3

21

O00425
GKIKPSFNIVPLTSR

IL13RA1

211

P78552
PRTSPKSVKFLFGGL

SLC25A11

16

Q02978
FTSFPSPPVLGKLKR

MBD3L3

6

A6NE82
GSVPALKTKPRFDFA

OSR1

106

Q8TAX0
GPPFKANTLIAFTKL

MED14

1291

O60244
RVKFSPSLTLFGGKP

MED16

161

Q9Y2X0
PPKFVFGSESVKRIF

RGPD3

1536

A6NKT7
SKPGKPRSTTNLFIL

GALR1

61

P47211
LKNIKIPSRFSTPEF

APOB

2636

P04114
PRIVKEFSSPKLFTA

C3orf49

126

Q96BT1
PFFRGVTIKSVILPL

CDC123

16

O75794
LRFGFKKITPVPEIT

DNAH17

2306

Q9UFH2
PSPLRTFKAFKVGTE

GLT6D1

126

Q7Z4J2
RPLVTESPTFKFSKS

CEP126

406

Q9P2H0
LGIAEPSLLKTFKPF

CPAMD8

791

Q8IZJ3
PSITKSVFSKFIPLI

CNTN1

216

Q12860
SFLPPSSVKKRGVLL

SQLE

391

Q14534
ARPQKPVSFKFLGSS

HEATR4

111

Q86WZ0
PTPKLFALRDVISKF

GLB1L

341

Q6UWU2
TVIEPLKKFGSVFPS

BIN3

106

Q9NQY0
PVSRGFPIAEVFTLK

HLA-DMA

121

P28067
VFTLKPLEFGKPNTL

HLA-DMA

131

P28067
LPTSIFLTNKKGFPV

PRMT5

231

O14744
RSVIRPPFKKFSKGV

DCTN5

66

Q9BTE1
IPGFPILINFKATKF

ALOX12B

181

O75342
PKRVATASPFSGLQK

MAPKBP1

1181

O60336
ATKPGKFTIAPVRQT

KIAA1210

1426

Q9ULL0
FFEAPRGKKQTIPSV

EML5

1151

Q05BV3
KSSPFKVSPLTFGRK

CAVIN2

286

O95810
KTLSSFFTPRKPAVK

LIG1

226

P18858
FFLIPAKTLTKTTPT

SLC13A1

396

Q9BZW2
PFRSFVPGPLKATLK

COL6A6

2196

A6NMZ7
VSKKFPGIRPYLATL

DGAT2

181

Q96PD7
FTSFPSPPVLGKLKR

MBD3L4

6

A6NDZ8
TIKKFRAGLSIFSPI

PARP6

166

Q2NL67
FTSFPSLPVLGKLKR

MBD3L2

6

Q8NHZ7
IIKPSFFPGSTRKSQ

RP1

1641

P56715
KTAFGIISTVKKPRP

RPP30

236

P78346
KPLFVEPRSKGSFSE

RTEL1

586

Q9NZ71
PPKFVFGSESVKRIF

RGPD4

1536

Q7Z3J3
TPLFIGKVRTLEFPF

SMCHD1

1551

A6NHR9
PTFQDRPVSSLKFGK

SH3BP4

646

Q9P0V3
PKTVRKGDVLTFPVS

TMEM132D

296

Q14C87
VSPPKFVFGSESVKR

RGPD2

1526

P0DJD1
GSRTPLKDILKLFPF

SAMD3

321

Q8N6K7
ILNPRTFPKSKFVSS

MYH15

736

Q9Y2K3
VILPVFLTFFPPSKK

PTCHD4

801

Q6ZW05
FTLGQKKISRLPGPT

NAV2

271

Q8IVL1
IDPSGKFPFISLASK

SIPA1L1

826

O43166
GPRPSFNKLSKVTIA

SHROOM3

1566

Q8TF72
LTKGKQQAFFVPPSR

NUDT12

431

Q9BQG2
PLVPVYSGKVKSSLR

NFATC2IP

121

Q8NCF5
TFKPIFGSIDPLKTT

POM121L2

576

Q96KW2
KRPSVSFAEGTKFAP

SCARF1

586

Q14162
AFTCKLKSPVPFLGR

SARDH

796

Q9UL12
SREKKALFQPLTPGS

TASOR

106

Q9UK61
VSFFSKAGQLPLVKP

CLTCL1

1436

P53675
IPLKKTPTSQRGFRF

ZNF624

191

Q9P2J8
KREFPTVPLVKLGSS

UGP2

421

Q16851
LGVRTFVPKPVATTL

WDFY3

1391

Q8IZQ1
SLPKFTVPKGRLGVT

ARHGAP40

206

Q5TG30
LPTPAAVAKGFSKRS

RGS12

1231

O14924
FPPGKVVITLFSIRL

RHCE

101

P18577
IFPLLTSFRCKKEGP

ELAC2

396

Q9BQ52
LTTPGSTLKFGAIRK

SYCP1

936

Q15431
KPPGTFLLRFSESSK

STAT3

601

P40763
ASKLRGISTKPVYIP

TRIM25

311

Q14258
IIIEPGFLFTTAKPK

SOGA1

1036

O94964
IKVFSSAKYPAPGRL

WASHC1

86

A8K0Z3
FPLFPLSKGFIKSIR

UBE2O

1256

Q9C0C9
IFSPFPSVKPLRKSA

TBC1D30

871

Q9Y2I9
PAFFELAKKVSSRVP

TTC21A

1011

Q8NDW8
LAKKVSSRVPLEPGF

TTC21A

1016

Q8NDW8
VPLSFEPVKSFFKGL

TRIM14

201

Q14142
LRSSISFPSGKKIGV

VPS13B

1901

Q7Z7G8
GTRLKPAKYIPVATA

ZDHHC8

6

Q9ULC8
SPRSNLGLFIKKPFI

TRPC5

351

Q9UL62
SFPAGKFTIKPLGFL

PLBD2

201

Q8NHP8
KEKLGFKPVPTSSFL

USP2

46

O75604
VSLLFKRTPPKAFEV

WDR64

961

B1ANS9
SLAPFDREPFTLGKK

LCP2

246

Q13094
DTPVKFARFPVTGLI

MYOM1

561

P52179