Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	TNPO1 RALGAPA1 PDS5B TNPO2 WDFY4 PI4KA PDS5A ATXN10 AGBL1 ARMC8 XPOT TANGO6	7.53e-07	339	110	12	IPR016024
Domain	HEAT_REPEAT	TNPO1 PDS5B TNPO2 PDS5A ARMC8 TANGO6	3.51e-06	70	110	6	PS50077
Domain	ARM-like	TNPO1 PDS5B TNPO2 WDFY4 PDS5A ATXN10 AGBL1 ARMC8 XPOT TANGO6	4.45e-06	270	110	10	IPR011989
Domain	-	TNPO1 PDS5B TNPO2 WDFY4 PDS5A ATXN10 ARMC8 XPOT TANGO6	6.61e-06	222	110	9	1.25.10.10
Domain	Bbox_C	FSD1 TRIM23 TRIM66	8.59e-05	15	110	3	IPR003649
Domain	BBC	FSD1 TRIM23 TRIM66	8.59e-05	15	110	3	SM00502
Domain	IBN_N	TNPO1 TNPO2 XPOT	8.59e-05	15	110	3	PF03810
Domain	IBN_N	TNPO1 TNPO2 XPOT	1.05e-04	16	110	3	SM00913
Domain	Importin-beta_N	TNPO1 TNPO2 XPOT	1.27e-04	17	110	3	IPR001494
Domain	AT_hook	PDS5B AHDC1 PHF21A	5.25e-04	27	110	3	SM00384
Domain	AT_hook_DNA-bd_motif	PDS5B AHDC1 PHF21A	5.25e-04	27	110	3	IPR017956
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PDS5B MYH6 ACTBL2 STXBP1 SBNO1 PABPC3 ETHE1 ARHGAP12 SYNE2 ITSN2 MTNR1A NAV2 SMARCC1 POTEJ POLQ CAMSAP2 PREX1	4.21e-06	1442	113	17	35575683
Pubmed	A protein interaction landscape of breast cancer.	EPPK1 DAB2 CASP8 PPM1G SERPINB9 PI4KA NAV2 SMARCC1 PDS5A PCM1 RAB5C	7.34e-06	634	113	11	34591612
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 PDS5B EPPK1 NUP214 PPM1G KARS1 SYNE2 SMARCC1 PDS5A PCM1 XPOT	9.68e-06	653	113	11	22586326
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RALGAPA1 EPPK1 TNPO2 EPB41L5 POLR2M NUP214 TAOK1 ATXN10 CAMSAP2 ARMC8	9.95e-06	533	113	10	25544563
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	1.05e-05	2	113	2	35986423
Pubmed	Transportin-1 and Transportin-2: protein nuclear import and beyond.	TNPO1 TNPO2	1.05e-05	2	113	2	24780099
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	1.05e-05	2	113	2	31757807
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	1.05e-05	2	113	2	34070827
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	1.05e-05	2	113	2	28830982
Pubmed	Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.	TNPO1 TNPO2	1.05e-05	2	113	2	9298975
Pubmed	Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.	CASP8 KARS1	1.05e-05	2	113	2	28611052
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SUCLA2 ITGB4 PPM1G STXBP1 PI4KA SYNE2 MTNR1A TANGO6	1.09e-05	322	113	8	26514267
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PDS5B TNPO2 AHDC1 PHF21A PPM1G KARS1 NFIL3 SMARCC1 PDS5A ELF1 MED17 C2orf49 PCM1 XPOT	1.42e-05	1103	113	14	34189442
Pubmed	Human transcription factor protein interaction networks.	TNPO2 NUP214 MORC4 PHF21A PPM1G PABPC3 SYNE2 SMARCC1 PDS5A ELF1 ATXN10 MED17 PCM1 EXOC4 XPOT TANGO6	1.57e-05	1429	113	16	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RALGAPA1 MYH6 ACTBL2 SUCLA2 PTK2B KARS1 STXBP1 PI4KA PABPC3 ITSN2 CAMSAP2 PCM1 RAB5C EXOC4 ARMC8 DNAH11	1.60e-05	1431	113	16	37142655
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TNPO1 RALGAPA1 ICE2 EPB41L5 NUP214 ADCY9 PPM1G ARHGAP12 PDS5A MED17 EXOC4	2.04e-05	708	113	11	39231216
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TNPO1 RALGAPA1 POGLUT3 EPB41L5 SUCLA2 ADCY9 PPM1G DNAJB13 TUBGCP6 LNPEP PI4KA SYNE2 ALAS1 ATXN10 PCM1 EXOC4	2.55e-05	1487	113	16	33957083
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	TNPO1 NUP214 SUCLA2 PPM1G TUBGCP6 PI4KA PDS5A CLEC16A RAB5C XPOT	2.98e-05	606	113	10	36538041
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	TNPO1 TNPO2 ATXN10 EXOC4 ARMC8 XPOT	3.10e-05	183	113	6	23956138
Pubmed	Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.	TRIM31 TMPRSS4	3.13e-05	3	113	2	35970857
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	3.13e-05	3	113	2	9786855
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	3.13e-05	3	113	2	17396146
Pubmed	Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.	POLQ POLK	3.13e-05	3	113	2	28939775
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	3.13e-05	3	113	2	24141881
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	3.13e-05	3	113	2	23585562
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	3.13e-05	3	113	2	28343969
Pubmed	ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.	TNPO1 TNPO2	3.13e-05	3	113	2	20606625
Pubmed	Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis.	CASP8 SERPINB9	3.13e-05	3	113	2	17479112
Pubmed	Involvement of transportin 2-mediated HuR import in muscle cell differentiation.	TNPO1 TNPO2	3.13e-05	3	113	2	17475777
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	EPPK1 RBM12B NUP214 PPM1G KARS1 PI4KA SYNE2 SMARCC1 RAB5C EXOC4 TANGO6	3.62e-05	754	113	11	35906200
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TNPO1 PDS5B NUP214 PPM1G TAOK2 KARS1 LPCAT2 PI4KA PDS5A ATXN10 EXOC4 XPOT	5.86e-05	942	113	12	31073040
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	ACTBL2 PHF21A NPM2 MED17	6.14e-05	65	113	4	22496869
Pubmed	Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.	TMPRSS4 SERPINB9	6.25e-05	4	113	2	16524950
Pubmed	Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.	PDS5B PDS5A	6.25e-05	4	113	2	29217591
Pubmed	The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.	TNPO1 TNPO2	6.25e-05	4	113	2	10875935
Pubmed	BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking.	MYH6 DAB2	6.25e-05	4	113	2	18429820
Pubmed	Karyopherin beta 2B participates in mRNA export from the nucleus.	TNPO1 TNPO2	6.25e-05	4	113	2	12384575
Pubmed	Delayed caspase-8 activation and enhanced integrin β1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.	CASP8 PTK2B	6.25e-05	4	113	2	21426305
Pubmed	The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice.	CYP3A43 NFIL3	6.25e-05	4	113	2	30796914
Pubmed	PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.	PDS5B PDS5A	6.25e-05	4	113	2	32285610
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	6.25e-05	4	113	2	10497253
Pubmed	Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.	TNPO1 TNPO2	6.25e-05	4	113	2	15037768
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	ADAD1 IL2RB CLEC16A	7.29e-05	25	113	3	21829393
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	TNPO1 ATXN10 XPOT	8.22e-05	26	113	3	23181366
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	TNPO1 ATXN10 XPOT	9.23e-05	27	113	3	23027611
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TNPO1 PDS5B TNPO2 SMARCC1 PDS5A ATXN10 MED17 EXOC4 XPOT	9.24e-05	560	113	9	35241646
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	EPPK1 EPB41L5 STXBP1 LPCAT2 PI4KA ATXN10 PCM1 EXOC4 XPOT	9.75e-05	564	113	9	21565611
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	1.04e-04	5	113	2	13679851
Pubmed	Primordial germ cell DNA demethylation and development require DNA translesion synthesis.	POLQ POLK	1.04e-04	5	113	2	38702312
Pubmed	Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.	NUP214 XPOT	1.04e-04	5	113	2	12138183
Pubmed	Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.	TAOK2 TAOK1	1.04e-04	5	113	2	22683681
Pubmed	Cloning and characterization of Cbl-associated protein splicing isoforms.	CASP8 SERPINB9	1.04e-04	5	113	2	12765336
Pubmed	Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.	NPM2 PTK2B TRIM66	1.15e-04	29	113	3	24105743
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 EPB41L5 FSD1 DENND2B PTK2B PI4KA SYNE2 NAV2 CAMSAP2 PCM1 EXOC4	1.18e-04	861	113	11	36931259
Pubmed	Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.	STXBP1 RAB5C EXOC4	1.27e-04	30	113	3	16186258
Pubmed	Purification and identification of G protein-coupled receptor protein complexes under native conditions.	PPM1G PI4KA MTNR1A	1.40e-04	31	113	3	17215244
Pubmed	Interaction network of human early embryonic transcription factors.	TNPO1 TNPO2 NUP214 MORC4 AHDC1 PHF21A SMARCC1	1.55e-04	351	113	7	38297188
Pubmed	Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.	KDM6B SMARCC1	1.56e-04	6	113	2	21095589
Pubmed	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.	PDS5B PDS5A	1.56e-04	6	113	2	15837422
Pubmed	Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.	STXBP1 PREX1	1.56e-04	6	113	2	26792863
Pubmed	Karyopherin beta2 mediates nuclear import of a mRNA binding protein.	TNPO1 NUP214	1.56e-04	6	113	2	9144189
Pubmed	Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.	ATXN10 PCM1	1.56e-04	6	113	2	30584065
Pubmed	The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.	TAOK2 TAOK1	1.56e-04	6	113	2	12639963
Pubmed	Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.	TAOK2 TAOK1	1.56e-04	6	113	2	16893890
Pubmed	Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.	DAB2 POLR2M ITGB4 ADCY9 KARS1 PABPC3	2.09e-04	259	113	6	9811942
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EPB41L5 WDFY4 TRIM66 PDS5A TAOK1 PREX1 EXOC4 TANGO6	2.15e-04	493	113	8	15368895
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5B PDS5A	2.17e-04	7	113	2	15855230
Pubmed	Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.	PDS5B PDS5A	2.17e-04	7	113	2	19412548
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TNPO1 DNHD1 PDS5B NUP214 SUCLA2 KARS1 SBNO1 PI4KA SMARCC1 PDS5A KIF3C ATXN10 ARMC8 XPOT	2.19e-04	1425	113	14	30948266
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TNPO1 DHX58 TNPO2 ACTBL2 DAB2 SUCLA2 PPM1G KARS1 SYNE2 PDS5A PCM1 EXOC4 ARMC8 XPOT	2.44e-04	1440	113	14	30833792
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	TNPO1 NUP214 KARS1 SMARCC1 PDS5A ATXN10 RAB5C EXOC4 XPOT	2.44e-04	638	113	9	33239621
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MORC4 STXBP1 SYNE2 ITSN2 SMARCC1 POTEJ MED17 PREX1 DNAH11	2.44e-04	638	113	9	31182584
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	WDFY4 ELF1 CLEC16A	2.59e-04	38	113	3	23273568
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH6 EPPK1 SUCLA2 ITGB4 PABPC3 ATXN10 RAB5C EXOC4 XPOT	2.71e-04	647	113	9	26618866
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5B PDS5A	2.89e-04	8	113	2	29867216
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5B PDS5A	2.89e-04	8	113	2	21699228
Pubmed	The tripartite motif family identifies cell compartments.	TRIM31 TRIM23 TRIM10	3.25e-04	41	113	3	11331580
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 KDM6B ADCY9 PHF21A TAOK2 TUBGCP6 KARS1 NAV2	3.44e-04	529	113	8	14621295
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5B PDS5A	3.71e-04	9	113	2	17349791
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5B PDS5A	3.71e-04	9	113	2	16682347
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5B PDS5A	3.71e-04	9	113	2	17112726
Pubmed	Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.	TNPO1 XPOT	3.71e-04	9	113	2	11024021
Pubmed	A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.	ADAD1 DAB2 CLEC16A	4.01e-04	44	113	3	23817569
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	RALGAPA1 PPM1G LNPEP CAMSAP2	4.07e-04	106	113	4	31024071
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5B PDS5A	4.63e-04	10	113	2	22751501
Pubmed	Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.	TNPO1 XPOT	4.63e-04	10	113	2	10944119
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5B PDS5A	4.63e-04	10	113	2	23242214
Pubmed	The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.	STXBP1 EXOC4	4.63e-04	10	113	2	11739749
Pubmed	Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.	CYP3A43 TAT	4.63e-04	10	113	2	26165599
Pubmed	Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart.	MYH6 DNAH11	4.63e-04	10	113	2	10679931
Pubmed	Sororin mediates sister chromatid cohesion by antagonizing Wapl.	PDS5B PDS5A	4.63e-04	10	113	2	21111234
Pubmed	Gene expression analysis of the embryonic subplate.	ZCCHC18 DPP10 CASP8 LRRN3 SYNE2	4.63e-04	196	113	5	21862448
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	DAB2 AHDC1 ITSN2 PREX1	4.84e-04	111	113	4	22558309
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PDS5B EFL1 EPPK1 SUCLA2 KARS1 STXBP1 SMARCC1 PDS5A EXOC4	4.99e-04	704	113	9	29955894
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TNPO1 PDS5B EPPK1 RBM12B ACTBL2 NUP214 PI4KA SYNE2 ATXN10 PCM1 RAB5C	5.17e-04	1024	113	11	24711643
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	PDS5B ZCCHC18 NUP214 TRIM10 ELF1 RAB5C XPOT	5.35e-04	431	113	7	33660365
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	TNPO1 DAB2 NUP214 ADCY9 LPCAT2 SYNE2 PCM1 EXOC4	5.50e-04	568	113	8	37774976
Pubmed	Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival.	MYH6 PCM1	5.65e-04	11	113	2	31286143
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5B PDS5A	5.65e-04	11	113	2	17113138
Pubmed	Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.	MYH6 PTK2B	5.65e-04	11	113	2	16374517
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM31 TRIM23 TRIM10 TRIM66	6.54e-04	95	75	4	59
GeneFamily	Dynein regulatory complex	TCTE1 IQCA1	9.12e-04	11	75	2	981
Coexpression	GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_DN	ZNF804A ENAM PTK2B TRIM66 NFIL3 PI4KA SYNE2 ITSN2 EXOC4	2.04e-07	200	112	9	M6372
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCTE1 EPPK1 C16orf46 IQCA1 CCDC180 DNAH11	7.35e-06	183	113	6	6ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCTE1 EPPK1 C16orf46 IQCA1 CCDC180 DNAH11	7.35e-06	183	113	6	18040d0653286071df959513c63d94b555a5d00a
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LNPEP ITSN2 SMARCC1 PDS5A ELF1 PCM1	7.58e-06	184	113	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Mild\|World / Disease group and Cell class	DHX58 LNPEP ELF1 TAOK1 IL2RB RAB5C	1.09e-05	196	113	6	5e4ed4a5a437cfa002b92775992a791e27aa4c27
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	EPB41L5 ADCY9 NAV2 AGBL1 L3MBTL4 EXOC4	1.15e-05	198	113	6	1996373bdccc55aac347d349bd22f6aad6d0c668
Disease	schizophrenia (implicated_via_orthology)	ZNF804A PPM1G LRRN3 SBNO1 PRODH	5.94e-06	68	111	5	DOID:5419 (implicated_via_orthology)
Disease	intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (implicated_via_orthology)	TNPO1 TNPO2	1.40e-05	2	111	2	DOID:0081262 (implicated_via_orthology)
Disease	waist circumference	RALGAPA1 ADCY9 PPM1G TAOK2 TRIM66 SYNE2 NAV2 ATXN10 PREX1	3.65e-05	429	111	9	EFO_0004342
Disease	multiple myeloma	KIF3C POLQ POLK PREX1 DNAH11	6.70e-05	112	111	5	EFO_0001378
Disease	serum metabolite measurement	TNPO1 RALGAPA1 DMGDH CYP3A43 SUCLA2 PHF21A PPM1G OR10AG1 SYNE2 CCDC180 AGBL1 PRODH	2.34e-04	945	111	12	EFO_0005653
Disease	response to selective serotonin reuptake inhibitor	TMPRSS4 AGBL1 PREX1 EXOC4	2.65e-04	82	111	4	EFO_0005658
Disease	type 1 diabetes mellitus	ADAD1 PI4KA ITSN2 CAMSAP2 IL2RB CLEC16A	3.16e-04	242	111	6	MONDO_0005147
Disease	Dermatitis, Irritant	TRIM31 TRIM10	4.96e-04	9	111	2	C0162823
Disease	glucagon-like peptide-1 measurement	ENAM AGBL1	6.19e-04	10	111	2	EFO_0008465
Disease	serum gamma-glutamyl transferase measurement	TNPO1 DMGDH ICE2 CASP8 ZNF804A DENND2B PPM1G SBNO1 ZNF827 NAV2 EXOC4	6.72e-04	914	111	11	EFO_0004532
Disease	Amelogenesis Imperfecta	ITGB4 ENAM	9.03e-04	12	111	2	C0002452
Disease	ascorbic acid 2-sulfate measurement	TAOK2 SLC23A3	1.06e-03	13	111	2	EFO_0800169
Disease	brain measurement, neuroimaging measurement	POLR2M SBNO1 FAM107B NAV2 AGBL1 EXOC4 TANGO6 DNAH11	1.14e-03	550	111	8	EFO_0004346, EFO_0004464
Disease	multiple myeloma, monoclonal gammopathy	KIF3C DNAH11	1.24e-03	14	111	2	EFO_0000203, EFO_0001378
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	PI4KA PRODH	1.24e-03	14	111	2	DOID:0060413 (implicated_via_orthology)
Disease	infant head circumference	SBNO1 PREX1	1.43e-03	15	111	2	EFO_0004577
Disease	pancreatitis	MORC4 STXBP1	1.63e-03	16	111	2	EFO_0000278
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	1.63e-03	16	111	2	DOID:331 (implicated_via_orthology)
Disease	cortical surface area measurement, neuroimaging measurement	IQCA1L NAV2 AGBL1 TANGO6 DNAH11	1.71e-03	227	111	5	EFO_0004346, EFO_0010736
Disease	eosinophil percentage of leukocytes	ICE2 TRIM31 KDM6B PTK2B NFIL3 ELF1 IL2RB CLCF1 CLEC16A	2.06e-03	746	111	9	EFO_0007991
Disease	estrogen-receptor negative breast cancer	POGLUT3 CASP8 ADCY9	2.46e-03	71	111	3	EFO_1000650
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	NAV2 PRKG2	2.81e-03	21	111	2	EFO_0000180, Orphanet_391311
Disease	atrial fibrillation	MYH6 POLR2M SYNE2 NAV2 KIF3C PCM1	2.84e-03	371	111	6	EFO_0000275
Disease	Paroxysmal atrial fibrillation	MYH6 SYNE2 NAV2 KIF3C	2.90e-03	156	111	4	C0235480
Disease	familial atrial fibrillation	MYH6 SYNE2 NAV2 KIF3C	2.90e-03	156	111	4	C3468561
Disease	Persistent atrial fibrillation	MYH6 SYNE2 NAV2 KIF3C	2.90e-03	156	111	4	C2585653
Disease	blood pressure	PREX1 EXOC4	3.08e-03	22	111	2	EFO_0004325
Disease	Hepatitis	PDS5B NAV2	3.08e-03	22	111	2	HP_0012115
Disease	Atrial Fibrillation	MYH6 SYNE2 NAV2 KIF3C	3.18e-03	160	111	4	C0004238
Disease	platelet crit	TNPO1 POGLUT3 EPB41L5 CASP8 KDM6B DENND2B SERPINB9 SBNO1 ELF1 PREX1	3.19e-03	952	111	10	EFO_0007985
Disease	insulin sensitivity measurement	DMGDH ARMC8	3.37e-03	23	111	2	EFO_0004471

Protein segments in the cluster

Peptide	Gene	Start	Entry
AEAMNNLKPPQAKRK	C2orf49	211	Q9BVC5
PGPMLDEKRINNNIF	ELF1	111	P32519
LTEAPLNPKINREKM	ACTBL2	106	Q562R1
KSPELVQAMFPKLNN	ATXN10	226	Q9UBB4
PQLVKGMKLLNQADP	EFL1	631	Q7Z2Z2
KQLKPAPFFQAQMIL	DNAH11	936	Q96DT5
FAQMLKKNLPVQPAT	ADAD1	16	Q96M93
MLLFQNPKRQKPAKF	DNHD1	3801	Q96M86
EPTPLLKMKNNGRNV	AHDC1	516	Q5TGY3
IDDVQVARMEPPKQK	CCDC180	1571	Q9P1Z9
QFPKLDRPTKQMREA	DENND2B	721	P78524
LDKEPQKMIEPQRNQ	IQCA1	21	Q86XH1
PLQLSLPKDFMDRNQ	DPP10	546	Q8N608
PFDTRMLDLQNNKIK	ASPN	101	Q9BXN1
LRENFIFKIIPMLNP	AGBL1	831	Q96MI9
KGRKLEQPMNLIPFV	CLYBL	156	Q8N0X4
PKAKQENRPQMLETK	C16orf46	356	Q6P387
PIKIMNLPFKANVNE	RBM12B	926	Q8IXT5
KQPTNPFLEMIKFLL	PDS5B	591	Q9NTI5
KQPTNPFLEMVKFLL	PDS5A	601	Q29RF7
MAIAKKLPKNEPQNA	RAB5C	176	P51148
PEKQLLNERIKNMQF	ITSN2	556	Q9NZM3
LKFSDPNNVPMVNKL	OVOS1	321	Q6IE37
VKEMFKDFQLRQPPA	DAB2	651	P98082
FQKNPILKQMLPEHQ	TCTE1	91	Q5JU00
LQPKPHQFQRMGKLI	OR10AG1	251	Q8NH19
IRAIVDNMKVKPNPN	TAT	56	P17735
LLKNFQDIMQKQRPE	ALAS1	166	P13196
DFKLPQFPLIQMTKE	NLRP11	36	P59045
QERQMLQALKFLPVP	FSD1	151	Q9BTV5
KPQLQELLKLPAFMR	KDM6B	1341	O15054
NFIPPEEKNKIMNRL	KIF3C	636	O14782
FLKKILARDPQQEPM	PCM1	256	Q15154
PENKFQIIKQEPMEL	NFIL3	211	Q16649
DKNRFPNPKRMQELL	GANC	411	Q8TET4
KPKREENPQKLAFMV	PHF21A	356	Q96BD5
PKVMEPILQILQQKF	PI4KA	631	P42356
PAKLSPMKQAQLRNF	NUP214	936	P35658
QQERFFLNMKPEIQP	LNPEP	631	Q9UIQ6
ALKQLPRNKVPNMAV	HROB	486	Q8N3J3
FLPNMKLEVVDKRNP	L3MBTL4	296	Q8NA19
QLQPDMSKLPARNKI	TUBGCP6	56	Q96RT7
DFKPDTMINLPQRAK	KIAA1549L	1211	Q6ZVL6
KIMVQFPRNQCKDLP	MED17	591	Q9NVC6
NDDNRPIGPMKKVLV	ITGB4	1261	P16144
NQFLKRLDPQQIKDM	PRKG2	166	Q13237
QKQKQMLGERLFPLI	PABPC3	551	Q9H361
KDLIRQLPKPNQDTM	ARHGAP12	766	Q8IWW6
KNDPVLFANKVRNLM	LPCAT2	296	Q7L5N7
MNMAQPKQLRPKREE	EXOC4	656	Q96A65
LPQIFVKMLQRDKPI	ARMC8	236	Q8IUR7
MRVPPDFKSNILKAQ	EPB41L5	556	Q9HCM4
RKVPELPLMNLENSK	ICE2	661	Q659A1
LNNPQDPFLKNMKKL	CYP3A43	196	Q9HB55
APQNKPELQKVMEKR	FAM107B	46	Q9H098
EPNIQNVPRDFEIKM	POLQ	2246	O75417
PEMKNARCVQKENPL	C7	681	P10643
QPLEFTFQKRDLPQM	DDX11L8	671	A8MPP1
IQDFKPFENLRLMAP	IL2RB	121	P14784
PENPKLEMLEKILQR	DHX58	346	Q96C10
QKAPIAFRPFKMQQI	ADCY9	376	O60503
DIKNPIQPSFKMLKN	C17orf80	111	Q9BSJ5
PQRKQEPIKDALMLF	CASP8	31	Q14790
EFVKIMGNLNLPKPQ	ETHE1	221	O95571
PEKIQEMFPLLNMNK	DMGDH	166	Q9UI17
IQFPTRLTPQKKQML	DNAJB13	296	P59910
KNQLGQKEIMPFPEA	ENAM	961	Q9NRM1
VRRKKQEVFMANPIP	DHRS7C	266	A6NNS2
DLFFPKQMQENLKPK	PTK2B	211	Q14289
EMRAKNPVPQLRKFK	POLR2M	236	P0CAP2
NSLNELMKLKPPANI	SBNO1	161	A3KN83
RVEILPPANQEDKKM	NPM2	61	Q86SE8
KDMPSIPVLNAAKRN	CAMSAP2	356	Q08AD1
PPLNQSAMLFIKVKD	PCDH11Y	476	Q9BZA8
KTKQNMPPRQLLEDI	TRIM31	236	Q9BZY9
KNAPTMEKKPELFNI	SULT1C3	6	Q6IMI6
LPLMIKKQDQPTFDN	SYNE2	671	Q8WXH0
SNNIKEVLLFPAMKP	KARS1	561	Q15046
GENPIIRIKDMNFKP	LRRN3	196	Q9H3W5
KKLPMPSLFDIRQNV	IQCA1L	526	A6NCM1
KRNKNLPPEEQMISA	PPM1G	406	O15355
VLVPAKDQPGRQEKM	EPPK1	3296	P58107
VPIVPFNQQNKKMII	MORC4	166	Q8TE76
PAPNNQKSMLEKLKL	NAV2	416	Q8IVL1
APLNPKANREKMTQI	POTEJ	771	P0CG39
AKNLRVKDQMPQGAP	PREX1	1631	Q8TCU6
EMQRKFNVEKPLIFN	PRODH	396	O43272
IELAERKPPLFNMNA	TAOK1	216	Q7L7X3
IELAERKPPLFNMNA	TAOK2	216	Q9UL54
VLQQNPPKFDKIEDM	MYH6	76	P13533
KAQMKNPILERLAEQ	STXBP1	161	P61764
QMLNFPEKNKEKPVD	SMARCC1	581	Q92922
KEQALQLAQKMGFPP	SUCLA2	216	Q9P2R7
QEARMPQKPREKAAQ	SLC23A3	531	Q6PIS1
NKGMDPEKLERIQLP	CLEC16A	511	Q2KHT3
DFNRLKKKMQPPAAA	CLCF1	201	Q9UBD9
PSINLQQMLKEVPKR	POGLUT3	171	Q7Z4H8
KVNKEDMSQKLPPLN	RALGAPA1	811	Q6GYQ0
REMPFKINQEEQRPV	SERPINB9	181	P50453
LNRPLNIMIPKFLQF	TNPO2	166	O14787
LPNRQAVMDFIKDLP	POLK	336	Q9UBT6
NLANPKIFRDLSKPM	WDFY4	2586	Q6ZS81
PKDNDIALMKLQFPL	TMPRSS4	286	Q9NRS4
ELDDIMKNFLFPPQK	TANGO6	1071	Q9C0B7
LDRPLNIMIPKFLQF	TNPO1	176	Q92973
QKEPMNLNFKVKEEP	ZNF827	586	Q17R98
RDFPQQALPLQREMK	TRIM10	281	Q9UDY6
NKQERLPNFLELIKM	ZCCHC18	201	P0CG32
MLNPQPEKTFIRNKA	XPOT	91	O43592
LFKLKQDEFMQPIPT	TRIM23	421	P36406
EMPVFKLKPQKNDQD	TRIM66	876	O15016
LPLENQMKESKRFPQ	SLC36A4	291	Q6YBV0
LQPNMLANKVKFTFP	ZNF804A	1056	Q7Z570
KPKLKPQDFRNFVTM	MTNR1A	226	P48039
LRIFEKFPNRPQMVK	NALCN	631	Q8IZF0