Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	POU	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	SM00352
Domain	POU_2	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	PS00465
Domain	Pou	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	PF00157
Domain	POU_dom	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	IPR000327
Domain	POU_3	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	PS51179
Domain	POU_1	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.01e-13	16	42	6	PS00035
Domain	POU	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.08e-12	17	42	6	IPR013847
Domain	-	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	2.55e-11	27	42	6	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	4.07e-11	29	42	6	IPR010982
Domain	TF_octamer	POU2F1 POU2F2 POU2F3	1.06e-08	3	42	3	IPR000972
Domain	TF_POU_3	POU3F1 POU3F2 POU3F3	4.22e-08	4	42	3	IPR016362
Domain	Homeobox_CS	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	3.50e-06	186	42	6	IPR017970
Domain	Homeodomain-like	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 EP400 POU2F3	8.32e-06	332	42	7	IPR009057
Domain	Homeobox	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.30e-05	234	42	6	PF00046
Domain	HOMEOBOX_1	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.37e-05	236	42	6	PS00027
Domain	HOX	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.40e-05	237	42	6	SM00389
Domain	Homeobox_dom	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.47e-05	239	42	6	IPR001356
Domain	HOMEOBOX_2	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	1.47e-05	239	42	6	PS50071
Domain	-	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	3.81e-05	283	42	6	1.10.10.60
Domain	CYSTEINE_SWITCH	ADAMTS17 ADAMTS19 MMP24	1.06e-04	41	42	3	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS17 ADAMTS19 MMP24	1.23e-04	43	42	3	IPR001818
Domain	PLAC	ADAMTS17 ADAMTS19	4.42e-04	14	42	2	PF08686
Domain	MetalloPept_cat_dom	ADAMTS17 ADAMTS19 MMP24	7.99e-04	81	42	3	IPR024079
Domain	-	ADAMTS17 ADAMTS19 MMP24	7.99e-04	81	42	3	3.40.390.10
Domain	PLAC	ADAMTS17 ADAMTS19	8.24e-04	19	42	2	IPR010909
Domain	PLAC	ADAMTS17 ADAMTS19	8.24e-04	19	42	2	PS50900
Domain	ADAM_spacer1	ADAMTS17 ADAMTS19	1.21e-03	23	42	2	IPR010294
Domain	ADAM_spacer1	ADAMTS17 ADAMTS19	1.21e-03	23	42	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS17 ADAMTS19	1.32e-03	24	42	2	IPR013273
Domain	ZINC_PROTEASE	ADAMTS17 ADAMTS19 MMP24	1.39e-03	98	42	3	PS00142
Domain	ADAM_Cys-rich	ADAMTS17 ADAMTS19	1.67e-03	27	42	2	IPR006586
Domain	ACR	ADAMTS17 ADAMTS19	1.67e-03	27	42	2	SM00608
Domain	P-loop_NTPase	ORC1 ABCB11 ARFRP1 GIMAP8 EP400 DNAH10 NLRP6	2.61e-03	848	42	7	IPR027417
Domain	Peptidase_M12B_N	ADAMTS17 ADAMTS19	3.47e-03	39	42	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS17 ADAMTS19	3.47e-03	39	42	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS17 ADAMTS19	3.65e-03	40	42	2	PS00427
Domain	ADAM_MEPRO	ADAMTS17 ADAMTS19	3.65e-03	40	42	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS17 ADAMTS19	3.65e-03	40	42	2	PS50214
Domain	Reprolysin	ADAMTS17 ADAMTS19	3.65e-03	40	42	2	PF01421
Domain	Peptidase_M12B	ADAMTS17 ADAMTS19	3.65e-03	40	42	2	IPR001590
Domain	Disintegrin_dom	ADAMTS17 ADAMTS19	3.83e-03	41	42	2	IPR001762
Domain	AAA+_ATPase	ORC1 ABCB11 DNAH10	4.14e-03	144	42	3	IPR003593
Domain	AAA	ORC1 ABCB11 DNAH10	4.14e-03	144	42	3	SM00382
Domain	WW_dom	HECW1 GALNT9	6.10e-03	52	42	2	IPR001202
Domain	-	ORC1 ABCB11 ARFRP1 GIMAP8 EP400 DNAH10	6.12e-03	746	42	6	3.40.50.300
Pubmed	Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.	POU2F1 POU2F2 POU3F1 POU2F3	2.44e-12	4	45	4	9242494
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU2F2 POU3F1 POU3F2 POU3F3	2.42e-09	14	45	4	17141158
Pubmed	High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.	POU2F1 POU2F2 POU3F1	8.09e-09	4	45	3	7720710
Pubmed	Cloning and sequencing of POU-boxes expressed in mouse testis.	POU2F1 POU2F2 POU2F3	8.09e-09	4	45	3	1970171
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F1 POU3F2 POU3F3	8.09e-09	4	45	3	1565620
Pubmed	Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.	POU3F1 POU3F2 POU3F3	8.09e-09	4	45	3	26265007
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F1 POU3F2 POU3F3	2.02e-08	5	45	3	9105675
Pubmed	Cooperative function of POU proteins and SOX proteins in glial cells.	POU3F1 POU3F2 POU3F3	2.02e-08	5	45	3	9632656
Pubmed	The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.	POU2F1 POU3F1 POU3F2	2.02e-08	5	45	3	12782656
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F1 POU3F2 POU3F3	4.04e-08	6	45	3	2739723
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	POU3F1 POU3F2 POU3F3	7.06e-08	7	45	3	17301088
Pubmed	Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.	POU2F1 POU3F2 POU3F3	1.13e-07	8	45	3	19147497
Pubmed	OCT-4: a novel estrogen receptor-α collaborator that promotes tamoxifen resistance in breast cancer cells.	POU2F1 POU2F2 POU2F3	1.13e-07	8	45	3	27065334
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F1 POU3F2 POU3F3	1.69e-07	9	45	3	15872005
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F1 POU3F2 POU3F3	4.42e-07	12	45	3	8276397
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F1 POU3F2 POU3F3	5.74e-07	13	45	3	8543156
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	POU3F1 POU3F2 POU3F3	9.11e-07	15	45	3	18255031
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F1 POU3F2 POU3F3	1.12e-06	16	45	3	9118797
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F1 POU3F2 POU3F3	1.12e-06	16	45	3	19527706
Pubmed	Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2.	POU2F1 POU2F2	1.64e-06	2	45	2	12663137
Pubmed	3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase the binding activity and nuclear level of Oct-1 in mononuclear cells.	POU2F1 POU2F2	1.64e-06	2	45	2	12144930
Pubmed	Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.	POU3F1 POU3F3	1.64e-06	2	45	2	8663425
Pubmed	Functional interaction of Oct transcription factors with the family of repeats in Epstein-Barr virus oriP.	POU2F1 POU2F2	1.64e-06	2	45	2	15831936
Pubmed	Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.	POU2F1 POU2F2	1.64e-06	2	45	2	11583619
Pubmed	Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake.	POU2F1 POU2F2	1.64e-06	2	45	2	31771949
Pubmed	Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.	POU2F1 POU2F2	1.64e-06	2	45	2	8156594
Pubmed	Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.	POU3F1 POU3F3	1.64e-06	2	45	2	9457692
Pubmed	Identification of novel single-stranded DNA binding proteins recognizing octamer motif.	POU2F1 POU2F2	1.64e-06	2	45	2	8185580
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	POU3F1 POU3F2 POU3F3	2.27e-06	20	45	3	11859196
Pubmed	CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.	POU2F1 POU2F3	4.91e-06	3	45	2	8376772
Pubmed	The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.	POU2F1 POU2F2	4.91e-06	3	45	2	2905684
Pubmed	PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.	PASK MTOR	4.91e-06	3	45	2	24445950
Pubmed	Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals.	POU3F2 POU3F3	4.91e-06	3	45	2	8703082
Pubmed	Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter.	POU2F1 POU2F2	4.91e-06	3	45	2	19710692
Pubmed	PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.	RSBN1 PHTF1	4.91e-06	3	45	2	18305142
Pubmed	Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.	POU2F1 POU2F2	4.91e-06	3	45	2	8622679
Pubmed	Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.	POU2F1 POU2F2	4.91e-06	3	45	2	10490647
Pubmed	Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.	POU2F1 POU2F2	4.91e-06	3	45	2	9584182
Pubmed	Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells.	POU2F1 POU2F2	4.91e-06	3	45	2	17442950
Pubmed	Oct1 is required for mTOR-induced G1 cell cycle arrest via the control of p27(Kip1) expression.	POU2F1 MTOR	4.91e-06	3	45	2	20935455
Pubmed	High mobility group I/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains.	POU2F1 POU2F2	4.91e-06	3	45	2	9823775
Pubmed	Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.	POU2F1 POU2F2	4.91e-06	3	45	2	14729950
Pubmed	The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP.	POU2F1 POU2F2	4.91e-06	3	45	2	8202368
Pubmed	Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.	POU3F1 POU2F3	4.91e-06	3	45	2	17195013
Pubmed	OBF1 and Oct factors control the germinal center transcriptional program.	POU2F1 POU2F2	4.91e-06	3	45	2	33512466
Pubmed	The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.	POU3F2 POU3F3	4.91e-06	3	45	2	16547000
Pubmed	Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.	POU2F1 POU2F2	4.91e-06	3	45	2	24367622
Pubmed	Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration.	POU2F1 POU2F2	4.91e-06	3	45	2	38254723
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	POU3F1 POU3F2 POU3F3	5.15e-06	26	45	3	22992956
Pubmed	Mutually repressive interaction between Brn1/2 and Rorb contributes to the establishment of neocortical layer 2/3 and layer 4.	POU3F2 POU3F3	9.81e-06	4	45	2	26951672
Pubmed	Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.	POU3F1 POU3F2	9.81e-06	4	45	2	22566684
Pubmed	A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells.	POU3F1 POU3F2	9.81e-06	4	45	2	15893976
Pubmed	Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.	POU2F1 POU2F2	9.81e-06	4	45	2	26016715
Pubmed	Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct.	POU2F1 POU3F3	9.81e-06	4	45	2	11997177
Pubmed	Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.	POU2F1 POU2F3	9.81e-06	4	45	2	8131747
Pubmed	The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.	POU2F1 POU2F2	9.81e-06	4	45	2	9368058
Pubmed	The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.	POU3F1 POU2F3	1.63e-05	5	45	2	23341029
Pubmed	POU family transcription factors in the nervous system.	POU2F1 POU3F1	1.63e-05	5	45	2	10199551
Pubmed	Characterization of enhancers active in the mouse embryonic cerebral cortex suggests Sox/Pou cis-regulatory logics and heterogeneity of cortical progenitors.	POU2F1 POU3F2	1.63e-05	5	45	2	23720416
Pubmed	Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1.	POU2F1 POU2F2	1.63e-05	5	45	2	11937630
Pubmed	S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.	POU2F1 POU2F2	1.63e-05	5	45	2	12887926
Pubmed	Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.	POU2F1 POU2F2	1.63e-05	5	45	2	16061936
Pubmed	Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.	POU3F1 POU3F2	2.45e-05	6	45	2	18505825
Pubmed	The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.	POU3F1 POU3F2	2.45e-05	6	45	2	21185279
Pubmed	Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.	POU3F2 POU3F3	2.45e-05	6	45	2	15465489
Pubmed	Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.	POU3F2 POU3F3	2.45e-05	6	45	2	15262984
Pubmed	The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination.	POU3F1 POU3F3	2.45e-05	6	45	2	15713637
Pubmed	Functional interaction between Oct-1 and retinoid X receptor.	POU2F1 POU2F2	2.45e-05	6	45	2	10383413
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS17 ADAMTS19	3.42e-05	7	45	2	11867212
Pubmed	Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization.	POU2F1 POU3F1	3.42e-05	7	45	2	17948256
Pubmed	POU homeodomain genes and myogenesis.	POU2F1 POU3F1	3.42e-05	7	45	2	8900043
Pubmed	The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.	POU2F1 POU2F2	4.56e-05	8	45	2	11279128
Pubmed	Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.	POU2F2 POU2F3	4.56e-05	8	45	2	8441607
Pubmed	POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.	POU3F2 POU3F3	4.56e-05	8	45	2	22892427
Pubmed	The Transcription Factor Pou3f1 Sheds Light on the Development and Molecular Diversity of Glutamatergic Cerebellar Nuclear Neurons in the Mouse.	POU3F1 POU3F2	4.56e-05	8	45	2	35935334
Pubmed	Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter.	POU2F1 POU2F2	5.86e-05	9	45	2	10480874
Pubmed	Chromosomal organization of mammalian POU domain factors.	POU3F2 POU3F3	5.86e-05	9	45	2	8276396
Pubmed	Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.	POU2F1 POU2F2	7.32e-05	10	45	2	32878923
Pubmed	NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.	HECW1 MTOR	8.94e-05	11	45	2	25555806
Pubmed	Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium.	POU3F2 POU3F3	1.07e-04	12	45	2	19743445
Pubmed	Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.	POU3F2 POU3F3	1.27e-04	13	45	2	19403657
Pubmed	Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.	POU2F2 POU3F1 POU3F2	1.38e-04	77	45	3	21525287
Pubmed	NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.	HECW1 MTOR	1.47e-04	14	45	2	27119228
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	POU3F1 POU3F2	1.47e-04	14	45	2	15273690
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	POU3F1 POU3F2 POU3F3	1.67e-04	82	45	3	31073041
Pubmed	Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.	ORC1 POU2F1	1.70e-04	15	45	2	12393188
Pubmed	DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.	POU3F3 GALNT9	1.70e-04	15	45	2	25556833
Pubmed	mTOR regulates brain morphogenesis by mediating GSK3 signaling.	POU3F3 MTOR	2.20e-04	17	45	2	25273085
Pubmed	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	ADAMTS17 MMP24 CHCHD7	2.27e-04	91	45	3	20546612
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	ADAMTS17 ADAMTS19	2.47e-04	18	45	2	35503090
Pubmed	Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.	ABCB11 PUM3	2.47e-04	18	45	2	24058526
Pubmed	PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.	POU3F1 POU3F2	2.76e-04	19	45	2	33597191
Pubmed	Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.	POU3F2 POU3F3	3.06e-04	20	45	2	12130536
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	POU3F1 POU3F2	3.38e-04	21	45	2	28880149
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	POU2F1 POU2F2 POU3F1 POU3F2	3.73e-04	263	45	4	20932939
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	CDC37 MTOR	4.82e-04	25	45	2	30340022
Pubmed	Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.	POU3F2 POU3F3	4.82e-04	25	45	2	39271675
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	POU2F1 POU2F2 POU3F1 POU2F3 PHTF1 ZNF566	5.81e-04	808	45	6	20412781
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ADAMTS19 RSBN1 PUM3 POU3F2 HECW1 PHTF1	6.04e-04	814	45	6	23251661
Pubmed	Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.	POU2F2 POU3F1	6.50e-04	29	45	2	30846445
Interaction	POU3F4 interactions	POU3F1 POU3F2 POU3F3	1.80e-07	6	43	3	int:POU3F4
Interaction	POU3F1 interactions	POU3F1 POU3F2 POU3F3	8.56e-06	19	43	3	int:POU3F1
Interaction	POU3F2 interactions	POU3F1 POU3F2 POU3F3	1.01e-05	20	43	3	int:POU3F2
Interaction	POU3F3 interactions	POU3F1 POU3F2 POU3F3	1.35e-05	22	43	3	int:POU3F3
Interaction	ENOX2 interactions	CDC37 SHMT2 ENOX1	4.30e-05	32	43	3	int:ENOX2
Cytoband	12q24.33	EP400 GALNT9	1.03e-03	48	45	2	12q24.33
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	GMPPB NT5DC2 IQCF6	3.70e-03	316	45	3	chr3p21
GeneFamily	POU class homeoboxes and pseudogenes	POU2F1 POU2F2 POU3F1 POU3F2 POU3F3 POU2F3	7.71e-13	23	28	6	523
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS19	3.89e-04	19	28	2	50
Coexpression	GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN	POU2F1 POU2F2 GIMAP8 PTAFR NT5DC2	2.18e-05	197	45	5	M5853
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HBZ	POU3F2 POU3F3 POU2F3	3.53e-05	37	45	3	M802
Coexpression	RIZ_ERYTHROID_DIFFERENTIATION_HBZ	POU3F2 POU3F3 POU2F3	3.53e-05	37	45	3	MM509
Disease	immune system disease (implicated_via_orthology)	POU2F1 POU2F2 POU2F3	3.09e-09	3	44	3	DOID:2914 (implicated_via_orthology)
Disease	event free survival time, type 1 diabetes mellitus, autoantibody measurement	RSBN1 PHTF1	1.42e-04	12	44	2	EFO_0000482, EFO_0004866, MONDO_0005147
Disease	temporal arteritis	RSBN1 PHTF1	1.42e-04	12	44	2	EFO_1001209
Disease	age at menarche	USP34 POU3F2 NT5DC2 GALNT9 IQCF6 NLRP6	2.39e-04	594	44	6	EFO_0004703
Disease	rheumatoid arthritis, ulcerative colitis	RSBN1 PHTF1	4.48e-04	21	44	2	EFO_0000685, EFO_0000729
Disease	Immunosuppressant use measurement	RSBN1 PHTF1	4.48e-04	21	44	2	EFO_0009934
Disease	acute kidney failure (implicated_via_orthology)	PTAFR MTOR	7.45e-04	27	44	2	DOID:3021 (implicated_via_orthology)
Disease	smoking behavior, BMI-adjusted waist circumference	ADAMTS17 DNAH10 NT5DC2	8.07e-04	122	44	3	EFO_0004318, EFO_0007789
Disease	Toxic Encephalitis	BCHE MTOR	8.60e-04	29	44	2	C0154659
Disease	Neurotoxicity Syndromes	BCHE MTOR	8.60e-04	29	44	2	C0235032
Disease	Encephalopathy, Toxic	BCHE MTOR	8.60e-04	29	44	2	C0149504
Disease	rheumatoid arthritis, celiac disease	RSBN1 PHTF1	1.11e-03	33	44	2	EFO_0000685, EFO_0001060
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	RSBN1 PHTF1	1.48e-03	38	44	2	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	myositis	RSBN1 PHTF1	1.55e-03	39	44	2	EFO_0000783
Disease	systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis	RSBN1 PHTF1	1.64e-03	40	44	2	EFO_1001999, EFO_1002019, EFO_1002020
Disease	monokine induced by gamma interferon measurement	RSBN1 PHTF1	2.75e-03	52	44	2	EFO_0008236
Disease	anti-neutrophil antibody associated vasculitis	RSBN1 PHTF1	2.75e-03	52	44	2	EFO_0004826
Disease	Metastatic melanoma	PASK MTOR	2.96e-03	54	44	2	C0278883

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRWKCLVIDEMQRVK	EP400	1211	Q96L91
NCRRFWNSIVMQRRK	CHCHD7	46	Q9BUK0
TRIMTKLRAQQCRFW	BCHE	536	P06276
CFWVIAAARQIQKMR	ABCB11	161	O95342
SAVERDRQWKFIMCR	DPT	176	Q07507
IREKNLCQDMRWYQR	ADAMTS17	1061	Q8TE56
IREKNLCQDMRWYQR	ADAMTS19	1176	Q8TE59
VRAKQMWEILRRKDC	PUM3	136	Q15397
MWELLQREKDRQCRG	SHMT2	56	P34897
WMGCNQKEVERRKER	MMP24	566	Q9Y5R2
WMKRMRQERRLCCVV	PASK	216	Q96RG2
RLVVQRCSGQKWMIR	GALNT9	581	Q9HCQ5
ERMVKWRVERGVVQQ	HECW1	1441	Q76N89
RCRVGQWVRMENVTV	GMPPB	311	Q9Y5P6
EKAIVREMCNVVWRK	CCDC85C	381	A6NKD9
MEKEVIRVWFCNRRQ	POU2F2	336	P09086
EVVRVWFCNRRQKEK	POU3F1	381	Q03052
VVKVQAQVRMWQARR	IQCF6	46	A8MYZ5
EKEVVRVWFCNRRQK	POU2F3	321	Q9UKI9
LNMEKEVIRVWFCNR	POU2F1	416	P14859
EVIRVWFCNRRQKEK	POU2F1	421	P14859
KKRARVQWFVRFCEV	ORC1	81	Q13415
VREGIEWMVKCVVRN	ARFRP1	176	Q13795
ERESQRCVITQWKMA	CCDC175	446	P0C221
WRHQARVERMEQFQK	CDC37	31	Q16543
IKMCQRESWVLRERK	GIMAP8	46	Q8ND71
CLQLVMWKVRQRAQI	REXO1L1P	646	Q8IX06
WQEELCLRFMREVER	FAAH	556	O00519
REVVQANCVRWRKKF	FAM102B	46	Q5T8I3
MERIAWEIAERVCRV	DNAH10	391	Q8IVF4
WRKCRMRIFTVAQVD	SLC12A7	871	Q9Y666
YEWECKQRMRAREER	ENOX1	226	Q8TC92
EKEVVRVWFCNRRQK	POU3F3	446	P20264
RVWFCNRRQKEKRMT	POU3F3	451	P20264
MVSERVKQEALRWVQ	NLRP6	566	P59044
CQRIVEDWQKILMVR	MTOR	1626	P42345
CVQWVDEAKLNQMRR	RSBN1	646	Q5VWQ0
EEIMRNQFSVKCWLR	XAB2	26	Q9HCS7
NMERTTIKKQERRCW	TMCO5B	226	A8MYB1
WKEAFRQRCLERMRN	RPAIN	21	Q86UA6
QRNAEVKRRALWMVC	PTAFR	221	P25105
NENIRLAARIMWRVE	SMYD1	101	Q8NB12
EVVRVWFCNRRQKEK	POU3F2	396	P20265
MIREWKNDCQRIEKQ	C10orf120	1	Q5SQS8
RQCRPEIRMWQTREK	PHTF1	236	Q9UMS5
QVLAAWMKERQELRC	NT5DC2	421	Q9H857
QWEIMEKLTRRDFQC	ZNF566	101	Q969W8
VCWFTDRQIRMRFIE	USP34	891	Q70CQ2