Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F

2.35e-0514823GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

1.65e-045822GO:0086007
GeneOntologyMolecularFunctionRNA polymerase III type 3 promoter sequence-specific DNA binding

MAF1 SNAPC3

2.47e-046822GO:0001006
GeneOntologyMolecularFunctionRNA polymerase III cis-regulatory region sequence-specific DNA binding

MAF1 SNAPC3

3.45e-047822GO:0000992
GeneOntologyMolecularFunctionRNA polymerase III transcription regulatory region sequence-specific DNA binding

MAF1 SNAPC3

4.59e-048822GO:0001016
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F

8.92e-0446823GO:0005245
GeneOntologyMolecularFunctionpoly(A) RNA polymerase activity

PAPOLA PAPOLG

1.07e-0312822GO:1990817
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1F STAC3

3.48e-0546844GO:0005891
GeneOntologyCellularComponentendosome

MRC1 AP3S1 CLTCL1 WASHC4 ZMPSTE24 MYO1D SBF2 TBCK CD164 ZFYVE26 FYCO1 TLR7 ACKR2 SLC9A6 TRAPPC1

5.71e-0511678415GO:0005768
GeneOntologyCellularComponentearly endosome

AP3S1 CLTCL1 WASHC4 ZMPSTE24 MYO1D TBCK ZFYVE26 ACKR2 SLC9A6

1.34e-04481849GO:0005769
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CACNA1F STAC3

2.14e-0473844GO:0034704
GeneOntologyCellularComponentT-tubule

CACNA1C CACNA1D STAC3 ABCC9

2.90e-0479844GO:0030315
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1C CACNA1D

1.03e-0312842GO:1990454
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

7.86e-083813IPR031688
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

7.86e-083813PF16885
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1F

3.13e-074813IPR005446
DomainVDCC_a1su_IQ

CACNA1C CACNA1D CACNA1F

2.72e-067813IPR014873
DomainGPHH

CACNA1C CACNA1D CACNA1F

2.72e-067813PF16905
DomainGPHH_dom

CACNA1C CACNA1D CACNA1F

2.72e-067813IPR031649
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

2.72e-067813SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

2.72e-067813PF08763
DomainVDCCAlpha1

CACNA1C CACNA1D CACNA1F

9.23e-0610813IPR002077
Domain-

PAPOLA PAPOLG

5.56e-0538123.30.70.590
DomainPAP_central

PAPOLA PAPOLG

5.56e-053812PF04928
DomainPAP_RNA-bind

PAPOLA PAPOLG

5.56e-053812PF04926
DomainPolA_pol_cen_dom

PAPOLA PAPOLG

5.56e-053812IPR007012
DomainPolA_pol_RNA-bd_dom

PAPOLA PAPOLG

5.56e-053812IPR007010
DomainPolyA_polymerase

PAPOLA PAPOLG

5.56e-053812IPR014492
DomainNuclTrfase_I_C

PAPOLA PAPOLG

5.56e-053812IPR011068
DomainNTP_transf_2

PAPOLA PAPOLG

9.96e-0411812PF01909
DomainPolymerase_NTP_transf_dom

PAPOLA PAPOLG

9.96e-0411812IPR002934
DomainP_typ_ATPase_c

ATP8B4 ATP8B1

1.63e-0314812IPR032630
DomainP-type_ATPase_N

ATP8B4 ATP8B1

1.63e-0314812IPR032631
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

1.63e-0314812IPR011704
DomainP-type_ATPase_IV

ATP8B4 ATP8B1

1.63e-0314812IPR006539
DomainPhoLip_ATPase_C

ATP8B4 ATP8B1

1.63e-0314812PF16212
DomainPhoLip_ATPase_N

ATP8B4 ATP8B1

1.63e-0314812PF16209
DomainAAA_5

MDN1 DNAH11

1.63e-0314812PF07728
DomainChannel_four-helix_dom

CACNA1C CACNA1D CACNA1F

1.94e-0357813IPR027359
Domain-

CACNA1C CACNA1D CACNA1F

1.94e-03578131.20.120.350
DomainChemokine_rcpt

CCR6 ACKR2

2.14e-0316812IPR000355
DomainLongin-like_dom

AP3S1 TRAPPC1

6.53e-0328812IPR011012
DomainFYVE

ZFYVE26 FYCO1

6.99e-0329812PF01363
DomainFYVE

ZFYVE26 FYCO1

6.99e-0329812SM00064
DomainThioredoxin

TUSC3 QSOX2

7.96e-0331812PF00085
Domain-

ATP8B4 ATP8B1

8.47e-03328123.40.1110.10
DomainLRRCT

LRRN1 TLR7

8.47e-0332812PF01463
Domain-

ATP8B4 ATP8B1

8.47e-03328122.70.150.10
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

1.61e-066623M47762
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1F

2.85e-0514623M47692
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

1.35e-0423623M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1D CACNA1F

1.74e-0425623M47948
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1F

5.43e-08484320937870
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1F

4.72e-07784312900400
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1D CACNA1F

2.21e-061184318809727
Pubmed

Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.

CACNA1C CACNA1D

5.76e-06284220014384
Pubmed

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.

ATG7 LEPR

5.76e-06284230653446
Pubmed

Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.

CACNA1C CACNA1D

5.76e-06284230001160
Pubmed

Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.

CACNA1C CACNA1D

5.76e-06284221352396
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

5.76e-06284221054386
Pubmed

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

CACNA1C CACNA1D

5.76e-06284217409250
Pubmed

Neuronal L-type calcium channels open quickly and are inhibited slowly.

CACNA1C CACNA1D

5.76e-06284216267232
Pubmed

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.

CACNA1C CACNA1D

5.76e-06284224996399
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

5.76e-06284225966695
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

5.76e-06284224086669
Pubmed

Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

CACNA1C CACNA1D

5.76e-06284224849370
Pubmed

Cav 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosis.

CACNA1C ZMPSTE24

5.76e-06284231120193
Pubmed

Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection.

CCR6 ACKR2

5.76e-06284224357920
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

5.76e-06284226049024
Pubmed

Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.

CACNA1C CACNA1D

5.76e-06284217015854
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

5.76e-06284219225208
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

5.76e-06284216706838
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

5.76e-06284223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

5.76e-06284214981074
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

5.76e-06284225292336
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

5.76e-06284217526649
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

5.76e-06284212606379
Pubmed

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

CACNA1C CACNA1D

5.76e-06284224941892
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

CACNA1C CACNA1D

5.76e-06284224848473
Pubmed

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.

CACNA1C CACNA1D

5.76e-06284222826131
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

5.76e-06284216921373
Pubmed

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

CACNA1C CACNA1D

5.76e-06284224470632
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.

CACNA1C CACNA1D

5.76e-06284224760982
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1C CACNA1D CACNA1F

6.06e-061584320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1C CACNA1D CACNA1F

6.06e-061584324453333
Pubmed

Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.

SFXN4 AP3S1 MRPS17 SENP3 CDS2 NCLN QSOX2 PTCD3

1.12e-0543884832628020
Pubmed

The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.

CACNA1C CACNA1D

1.73e-05384219351867
Pubmed

Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.

CACNA1C CACNA1D

1.73e-05384221832054
Pubmed

Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.

CACNA1C CACNA1D

1.73e-05384217289261
Pubmed

Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.

CACNA1C CACNA1D

1.73e-05384223973784
Pubmed

Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).

CACNA1C CACNA1D

1.73e-05384217767505
Pubmed

MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels.

CACNA1C CACNA1D

1.73e-05384231302118
Pubmed

Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.

CACNA1C CACNA1D

1.73e-05384223045342
Pubmed

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.

CACNA1C CACNA1D

1.73e-0538422173707
Pubmed

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

CACNA1C CACNA1D

1.73e-05384224934288
Pubmed

Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.

GRB10 LEPR

1.73e-05384236593271
Pubmed

Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice.

G6PC1 LEPR

1.73e-05384221081500
Pubmed

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

CACNA1C CACNA1D

1.73e-05384226831068
Pubmed

Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.

CACNA1C CACNA1D

1.73e-05384223338940
Pubmed

Exendin-4 improves β-cell function in autophagy-deficient β-cells.

ATG7 LEPR

1.73e-05384224105478
Pubmed

Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.

CACNA1D CACNA1F

1.73e-05384226024096
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

FANCD2 TNPO1 KIFBP AP3S1 WASHC4 FBXO3 WDR75 MYO1D ATG7 MRPS17 TBCK CDC23 PTCD3

1.84e-051335841329229926
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MDN1 WDR75 MYO1D SENP3 CDS2 ZMYM2 NCLN PREX1 DNAH11

2.41e-0563884931182584
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ATP8B4 LRRN1 SBF2 UBR3 RALGAPA2 FAM135A PREX1 FARP2

2.62e-0549384815368895
Pubmed

HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance.

CCR6 LEPR

3.45e-05484225098764
Pubmed

Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.

CACNA1C CACNA1D

3.45e-05484217110593
Pubmed

The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.

MDN1 SENP3

3.45e-05484227814492
Pubmed

FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body.

ATP8B4 ATP8B1

3.45e-05484212880872
Pubmed

Role of the mannose receptor in phagocytosis of Enterococcus faecalis strain EC-12 by antigen-presenting cells.

MRC1 TLR7

3.45e-05484223801521
Pubmed

Tat-dependent occlusion of the HIV poly(A) site.

PAPOLA PAPOLG

3.45e-0548428491200
Pubmed

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.

GRB10 LEPR

3.45e-05484226941017
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

SFXN4 MDN1 WDR75 MYO1D SENP3 ZMYM2

4.29e-0526284636880596
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1C CACNA1D

5.74e-05584215451373
Pubmed

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.

CACNA1C CACNA1D

5.74e-05584231663850
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1C CACNA1D

5.74e-05584211296258
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

MAF1 FBXO3 NRK SENP3 ZMYM2 NCLN PHYHIPL FAM135A PREX1

8.37e-0575084911230166
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1C CACNA1D

8.59e-05684216029198
Pubmed

Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.

CACNA1C CACNA1D

8.59e-05684221224388
Pubmed

The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse.

C8A LEPR

8.59e-05684212446734
Pubmed

L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.

CACNA1C CACNA1D

8.59e-05684223734214
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C CACNA1D CACNA1F

1.08e-043884330786075
Pubmed

The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.

MDN1 SENP3

1.20e-04784221326211
Pubmed

CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.

ATP8B4 ATP8B1

1.20e-04784220961850
Pubmed

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.

ATP8B4 ATP8B1

1.20e-04784220947505
Pubmed

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.

CACNA1C TRANK1

1.20e-04784224280982
Pubmed

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.

FANCD2 ATG7

1.20e-04784224184056
Pubmed

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.

G6PC1 LEPR

1.60e-04884227631554
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1D CACNA1F

1.60e-04884228330839
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1C CACNA1F

2.05e-04984216382099
Pubmed

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.

ATG7 TLR7

2.05e-04984218097414
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

CACNA1C CACNA1D SLC4A7 TUSC3 ATP8B1 FARP2

2.86e-0437184615747579
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1C CACNA1D CACNA1F ABCC9

3.68e-0413984416985003
Pubmed

Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.

GRB10 LEPR

3.75e-041284217182038
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

MAF1 ATP8B4 TRANK1 CLTCL1 HMGB4 VASH1 DNAH11

3.85e-0455284710737800
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP8B4 ATP8B1

4.42e-041384211015572
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SFXN4 AP3S1 SLC4A7 ZMPSTE24 WDR75 MRPS17 TRAM1 SENP3 NCLN

4.88e-0495284938569033
Pubmed

NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.

ATG7 FYCO1

5.15e-041484231857374
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

SFXN4 MYO1D MRPS17 SENP3 PTCD3

5.26e-0427284525315684
Pubmed

Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.

HMGB4 FAM135A

5.93e-041584220970119
Pubmed

Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.

CCR6 ACKR2

5.93e-04158429139699
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

TNPO1 MDN1 SENP3 ZMYM2 CDC23

6.19e-0428284523667531
Pubmed

Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.

LEPR APOBEC3F

6.77e-041684233904407
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

FANCD2 TNPO1 KIFBP AP3S1 CLTCL1 MDN1 MRPS17 TRAM1 NCLN TRAPPC1 PTCD3

6.85e-041440841130833792
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

CACNA1C CACNA1D

7.66e-041784227725084
Pubmed

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.

MRC1 ABCC9

7.66e-041784228634350
Pubmed

Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.

GRB10 LEPR

8.60e-041884223085235
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CACNA1C LPAR3 LRRN1 ATG7 INPP5A SBF2 TUSC3 TBCK GRB10 ATP8B1 FARP2

9.01e-041489841128611215
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

FANCD2 SFXN4 KIFBP SLC4A7 MDN1 WDR75 MYO1D MRPS17 NCLN CDC23 PTCD3

9.36e-041496841132877691
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SLC4A7 MDN1 WDR75 UTP25 MRPS17 TRAM1 SENP3 ZMYM2 PREX1 PTCD3 FARP2

9.41e-041497841131527615
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

FANCD2 WDR75 MYO1D ZMYM2 FARP2

9.88e-0431384538270169
Pubmed

A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.

CACNA1D FYCO1

1.06e-032084235224516
Pubmed

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.

MDN1 SENP3

1.17e-032184237014752
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1D CACNA1F

7.73e-0526583253
GeneFamilyATPase phospholipid transporting

ATP8B4 ATP8B1

1.03e-03155821210
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

TNPO1 SLC4A7 MDN1 WASHC4 UTP25 PAPOLA MRPS17 TRAM1 SENP3 CD164 ZMYM2 TLR7 SNAPC3 SLC16A7 SLC9A6

5.64e-0612158315M41122
CoexpressionAtlaskidney_adult_RenCorpuscGlomer_k-means-cluster#2_top-relative-expression-ranked_100

MRC1 MYO1D ART3

3.50e-0517813gudmap_kidney_adult_RenCorpuscGlomer_k2_100
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000

CACNA1D ADGRG3 WASHC4 MYO1D PAPOLA GRB10 UBR3 ATP8B1 SNAPC3 PHYHIPL FAM135A CDC23

3.55e-057748112gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

ADGRG3 AP3S1 SLC4A7 MDN1 WDR75 GVINP1 STAC3 ZMYM2 UBR3 FYCO1 ACKR2 FAM135A PREX1 FMNL1 LEPR

6.85e-0512528115facebase_RNAseq_e10.5_MaxArch_2500_K3
ToppCellDendritic_Cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ATP8B4 SLC4A7 VASH1 CCR6 TLR7 PREX1

1.67e-06191846b51c8ff1279581088557bb36760c70209c77148c
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1D SBF2 GRB10 RALGAPA2 FAM135A LEPR

1.77e-06193846e1d546165dcc2392f540162206852c4717d7306f
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 TLR7 PREX1 FMNL1

2.00e-06197846e0fc098bfb5a8b7824ae339f3adda30f78360d0b
ToppCellParenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 CCR6 PREX1 FMNL1

2.00e-06197846363ae03310f63a586ba3cea2a59f35d5a335a54e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 VASH1 TLR7 PREX1 FMNL1

2.00e-0619784657dafb3047745a44b2345b8036e159c3641d496e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 VASH1 TLR7 PREX1 FMNL1

2.06e-06198846623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCellParenchymal-NucSeq-Immune_Myeloid-Dendritic_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 CCR6 PREX1 FMNL1

2.18e-06200846f19b729b03b5f225b9ed676f0ac31071a4354da3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC4A7 VASH1 ABCC9 TLR7 LEPR

9.62e-061508456c39e73a0b05d4b26589f333ce13924e3d373b8d
ToppCellE16.5-samps-Myeloid-Fetal_macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 ATP8B4 GVINP1 TLR7 FMNL1

1.06e-05153845e9567966fe4426176e2f2dc0be4832c769c9903a
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 CACNA1F ZFYVE26 TLR7 FMNL1

1.35e-051618455a8698790f9aba796dd2b64af419055c60bd7de8
ToppCellE18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 ATP8B4 GVINP1 TLR7 FMNL1

1.40e-0516284560d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCellE18.5-samps-Myeloid|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 ATP8B4 GVINP1 TLR7 FMNL1

1.40e-0516284518e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCellE18.5-samps-Myeloid-Macrophage|E18.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 ATP8B4 GVINP1 TLR7 FMNL1

1.40e-051628450970e4eda60e3f015335e2726e6d565fb2f43372
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LPAR3 ADGRG3 CFAP119 RSPH10B DNAH11

1.71e-051698458bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|368C / Donor, Lineage, Cell class and subclass (all cells)

KIFBP SBF2 STAC3 VASH1 CFAP119

1.81e-0517184526b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell5'-Adult-Distal_Rectal-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 CACNA1F SLC16A7 FMNL1 QSOX2

1.92e-05173845b335ca2a247156eba821943b2b9fc9922230b409
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SLC4A7 ART3 ATP8B1 G6PC1

1.92e-051738452415b6ff49f334da570577d4e93484d024a3dbd5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SLC4A7 ART3 ATP8B1 G6PC1

1.92e-051738452acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MAF1 ADGRG3 HS3ST4 RSPH10B

2.02e-051758459a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MAF1 ADGRG3 HS3ST4 RSPH10B

2.02e-0517584554c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 MAF1 ADGRG3 HS3ST4 RSPH10B

2.02e-051758452b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRG3 ATP8B4 CCR6 PREX1 FMNL1

2.08e-05176845238244294d08975df6bfa26b2b437db3654408ae
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRG3 ATP8B4 FYCO1 CCR6 FMNL1

2.20e-051788450b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 STAC3 VASH1 NCLN FMNL1

2.20e-051788450b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C CACNA1D SLC4A7 FAM135A FARP2

2.20e-05178845fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 CCR6 ACKR2 PREX1 FMNL1

2.26e-05179845dd3cf8fd10dc257d933a7f45860dc2e244c158b7
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

CACNA1D LPAR3 ATP8B4 CFAP119 CCR6

2.44e-051828458dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCellCOVID-19-APC-like-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

ATP8B4 VASH1 CCR6 PREX1 FMNL1

2.51e-05183845703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCellCOVID-19-APC-like|COVID-19 / group, cell type (main and fine annotations)

ATP8B4 VASH1 CCR6 PREX1 FMNL1

2.51e-05183845b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ADGRG3 ATP8B4 CCR6 PREX1 FMNL1

2.57e-0518484551ae0963b4fb034c3f605ee4e5da513cba7aca35
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

ATP8B4 NRK ABCC9 TLR7 LEPR

2.57e-0518484567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBCK STAC3 SLC16A7 DNAH11 APOBEC3F

2.71e-0518684577bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TBCK STAC3 SLC16A7 DNAH11 APOBEC3F

2.71e-0518684513bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CACNA1D SBF2 TBCK C8A PHYHIPL

2.78e-05187845f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRG3 SLC4A7 NRK FAM135A LEPR

3.08e-051918452fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellCOPD-Myeloid-cDC2|Myeloid / Disease state, Lineage and Cell class

ATP8B4 MYO1D INPP5A CCR6 PAPOLG

3.16e-05192845984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.16e-0519284586d792682ba51696f503c79625dd20f87bcf651f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.16e-05192845d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCellMonocytes-Tissue-resident_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

TNPO1 SLC4A7 VASH1 FAM135A PAPOLG

3.23e-05193845198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.23e-051938453e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.23e-05193845f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellDendritic_Cells|World / lung cells shred on cell class, cell subclass, sample id

ATP8B4 VASH1 CCR6 PREX1 FMNL1

3.23e-051938457792eb6e247af2d7a8f80476f37dcd880922d625
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 ATG7 PREX1 FMNL1

3.32e-0519484545708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 ATG7 PREX1 FMNL1

3.40e-05195845247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellCF-Myeloid|CF / Disease state, Lineage and Cell class

ADGRG3 ATG7 SBF2 RALGAPA2 PREX1

3.40e-05195845ecf604de496f389a49429d0bb211e1db6019cc8b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.40e-0519584509df40ff9b493170861b3f6e57a942a834655b5c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 PREX1 FMNL1

3.48e-051968454370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellCOVID-19-Myeloid-Transitioning_MDM|COVID-19 / group, cell type (main and fine annotations)

MRC1 ATP8B4 ATG7 SBF2 PREX1

3.48e-051968454929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 VASH1 PREX1 FMNL1

3.48e-05196845291c59b609985167c98a40d4e2caeea2fad74941
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 ATG7 PREX1 FMNL1

3.57e-051978458af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

MRC1 ATP8B4 ATG7 PREX1 FMNL1

3.57e-051978453896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 VASH1 PREX1 FMNL1

3.57e-05197845dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 VASH1 PREX1 FMNL1

3.57e-05197845826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 ATG7 PREX1 FMNL1

3.57e-051978451eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCellTracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 CCR6 TLR7 FMNL1

3.65e-0519884525b40926412a15ca91f30cd57a547a60396e9dd3
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP8B4 VASH1 TLR7 PREX1 FMNL1

3.74e-05199845744b63fba33b176ab7dde11646ccb313665505f7
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 TLR7 PREX1

3.74e-051998456ce7612ee2ae211eb0f73391e96089ad5431c537
ToppCellTracheal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 PREX1 FMNL1

3.83e-05200845ad7ae5106141669b353800fece833b3cd5bdccee
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 TLR7 PREX1

3.83e-05200845f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 ATP8B4 VASH1 PREX1 FMNL1

3.83e-0520084546f9c28b24e39acdf0481a02b6eb86ecdd83c504
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8|TCGA-Thymus / Sample_Type by Project: Shred V9

NRK FYCO1 CCR6 LEPR

1.91e-041518445906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 NRK SLC16A7 RSPH10B

2.01e-041538440307f10e772021ae68a42690634df458672a6df9
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

SFXN4 CACNA1F VASH1 ATP8B1

2.06e-0415484426bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

KCTD14 ZMYM2 RSPH10B DNAH11

2.16e-0415684410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellE16.5-samps-Myeloid|E16.5-samps / Age Group, Lineage, Cell class and subclass

MRC1 GVINP1 TLR7 FMNL1

2.16e-04156844c7c73cef5700b0ae75280e62c94728434c712537
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MRC1 ADGRG3 LRRN1 ACKR2

2.56e-04163844961c3a1303108afd680365466045f3460a30a7b0
ToppCellCOPD-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

LPAR3 ATP8B4 MYO1D CCR6

2.62e-04164844a07c6e13c07a90bc37db0915eb14931eb8309a1e
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LPAR3 NRK ACKR2 LEPR

2.68e-04165844570483b43ccb5831feec9337b4664814431d40b1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LPAR3 NRK ACKR2 LEPR

2.68e-041658442026a9a07f4d314cc05c167e491312b373468e46
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACNA1F SLC4A7 WDR75 QSOX2

2.74e-04166844ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MRC1 ATP8B4 TLR7 FMNL1

2.74e-0416684499dc8a186ec12d3563e81fa4618a814740332c73
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MRC1 ATP8B4 STAC3 SLC9A6

2.87e-04168844d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

MRC1 LPAR3 STAC3 VASH1

2.87e-041688448ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCellDendritic_Cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ATP8B4 CCR6 PREX1 FMNL1

2.87e-0416884433618e5dbcee31f30afacacc9f6046782c100fb3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 FMNL1

2.93e-04169844b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 ATP8B4 TLR7 FMNL1

2.93e-041698442322f03a115c662f808ebfc892192b7d38d48181
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLTCL1 CCR6 QSOX2 FARP2

3.07e-04171844c3e3ea09c73050372314a89b282e36ba5f339d73
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 LPAR3 ATP8B4 PREX1

3.14e-0417284472fbfa890995e47048b47199c170cc7dcd7661f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 LPAR3 ATP8B4 PREX1

3.14e-041728442ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCellCD8+_Memory_T_cell-FLU-3|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

WDR75 CFAP119 CCR6 SNAPC3

3.14e-0417284445ac433dbb3796f69e886c04457b2971403050ee
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 ATP8B4 CD164 PREX1

3.14e-04172844584af6537685cb459bf0fc298e6f46872016c116
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C CACNA1D SLC4A7 FAM135A

3.28e-04174844f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C GRB10 ABCC9 ATP8B1

3.28e-04174844015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SFXN4 TRANK1 ZFYVE26 PTCD3

3.35e-04175844bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATP8B4 SLC4A7 PREX1 FMNL1

3.35e-04175844f2c3e0f728a43d6988e793c8a50c964f7447db82
ToppCellfacs-Skin-Telogen-3m-Lymphocytic-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 ATP8B4 PREX1 FMNL1

3.42e-041768443d372c1d527fcc118d1e5809f2524fc387682472
ToppCellfacs-Skin-Telogen-3m-Lymphocytic|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 ATP8B4 PREX1 FMNL1

3.42e-041768447b3f3d9b33770edf294cee0eccaf8a46f9331461
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 ADGRG3 NRK RSPH10B

3.42e-041768445d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCellfacs-Skin-Telogen-3m-Lymphocytic-T_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 ATP8B4 PREX1 FMNL1

3.42e-041768449c0fb2c6ae84febdf7c3d4e648985f597dcffe7a
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FANCD2 NRK CORIN LEPR

3.50e-0417784430f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 LPAR3 ATP8B1 G6PC1

3.57e-041788447467e5ab2fcb39cc4a2c7dd69722c91def3b6aea
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 ADGRG3 ACKR2 RALGAPA2

3.65e-04179844abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 ADGRG3 ACKR2 RALGAPA2

3.65e-041798440b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 CD164 ZFYVE26 NLRP2

3.80e-04181844a8d4b2340d99734bf9379b467fb481c598b9b4fb
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRG3 INPP5A VASH1 RALGAPA2

3.80e-04181844a53f05c4c47465ee62e353716456bd09ab464b23
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRG3 VASH1 ATP8B1 FARP2

3.80e-04181844136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADGRG3 ATP8B4 AP3S1 LRRN1

3.88e-0418284452eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 ATP8B4 TLR7 FMNL1

3.88e-041828444a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 ATP8B4 TLR7 FMNL1

3.88e-0418284453213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 ADGRG3 ACKR2 RALGAPA2

3.88e-04182844fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
DrugCinnarizine

CACNA1C CACNA1D CACNA1F

3.86e-069833DB00568
DrugNimodipine

CACNA1C CACNA1D CACNA1F

3.86e-069833DB00393
DrugMibefradil

CACNA1C CACNA1D CACNA1F

7.55e-0611833DB01388
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

7.37e-084793DOID:0060173 (implicated_via_orthology)
DiseaseAntibody Deficiency Syndrome

CACNA1C C8A LEPR

1.22e-0517793C0003257
DiseaseImmunologic Deficiency Syndromes

CACNA1C C8A LEPR

3.15e-0523793C0021051
DiseaseFEV change measurement, response to zileuton

GRB10 CCR6 SLC16A7

4.07e-0525793EFO_0005921, EFO_0007676
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

1.24e-0436793DOID:11723 (implicated_via_orthology)
Diseasehypertension

CACNA1D SLC4A7 UTP25 MYO1D INPP5A SBF2

1.78e-04307796EFO_0000537
DiseaseShortened QT interval

CACNA1C ABCC9

3.83e-0411792C0151879
DiseaseManic Disorder

CACNA1C CACNA1D TRANK1

9.26e-0471793C0024713
DiseaseC-X-C motif chemokine 16 measurement

FYCO1 ACKR2

1.05e-0318792EFO_0010911
Diseasepulse pressure measurement

CACNA1D ATP8B4 TRANK1 SLC4A7 ATG7 INPP5A SBF2 UBR3 ABCC9 QSOX2 PTCD3

1.17e-0313927911EFO_0005763
DiseaseManic

CACNA1C CACNA1D TRANK1

1.22e-0378793C0338831
DiseaseDepression, Bipolar

CACNA1C CACNA1D TRANK1

1.26e-0379793C0005587
DiseaseCOVID-19, osteoarthritis

FYCO1 ACKR2

1.30e-0320792MONDO_0005178, MONDO_0100096
Diseasealanine measurement

TNPO1 CLTCL1 SLC16A7

1.61e-0386793EFO_0009765
Diseaseautism spectrum disorder symptom

LPAR3 CCR6

1.73e-0323792EFO_0005426
DiseaseDyslipidemias

LEPR DNAH11

1.88e-0324792C0242339
DiseaseAnhedonia

CACNA1C CCR6

1.88e-0324792C0178417
DiseaseDyslipoproteinemias

LEPR DNAH11

1.88e-0324792C0598784
DiseaseBrugada Syndrome (disorder)

CACNA1C ABCC9

1.88e-0324792C1142166
Diseasediet measurement

TNPO1 TRANK1 FBXO3 TUSC3 UBR3 CAPZA3 RALGAPA2 SLC16A7 LEPR

1.94e-031049799EFO_0008111
DiseaseEndogenous Hyperinsulinism

MRC1 LEPR

2.21e-0326792C1257963
DiseaseExogenous Hyperinsulinism

MRC1 LEPR

2.21e-0326792C1257964
DiseaseCompensatory Hyperinsulinemia

MRC1 LEPR

2.21e-0326792C1257965
Diseasemean arterial pressure

CACNA1D SLC4A7 UTP25 ATG7 INPP5A PREX1

2.23e-03499796EFO_0006340
DiseaseHyperinsulinism

MRC1 LEPR

2.56e-0328792C0020459

Protein segments in the cluster

PeptideGeneStartEntry
LYAFSSHRFRQYLKA

ACKR2

311

O00590
YRFFDHQSKLSFKYD

CAPZA3

81

Q96KX2
TAFRYLAQYYFKCKL

CDC23

511

Q9UJX2
FRKPYNFLKYHFEAL

C8A

206

P07357
YLHNSKSFFRSYIKN

GVINP1

2146

Q7Z2Y8
KSFFRSYIKNHIKRY

GVINP1

2151

Q7Z2Y8
YAFIGQKFRNYFLKI

CCR6

316

P51684
FVLSLVKKHYRLQFY

CDS2

181

O95674
KNSFFNYRKKLASYF

DNAH11

431

Q96DT5
FNTYFGHYFLKLSLV

ADGRG3

371

Q86Y34
FYFIQKYFRVASKDL

ABCC9

1146

O60706
KFLCYFFYKNFAFTL

ATP8B4

871

Q8TF62
NKLIYRHYATLYFVF

AP3S1

61

Q92572
LRYFFYKNFAFTLVH

ATP8B1

951

O43520
IHFYPTFRYFKAFTK

QSOX2

136

Q6ZRP7
YKRTHAAYNLLFFAS

NCLN

261

Q969V3
YVFFVNTLFHAYKRE

RSPH10B

766

P0C881
YVFFVNTLFHAYKRE

RSPH10B2

766

B2RC85
GKFYATFLIQDYFRK

CACNA1F

1581

O60840
DQHRNFYYSKFFDLI

PTCD3

451

Q96EY7
LYHYYKQFFDRVQAK

MDN1

3916

Q9NU22
FNYFFYNKRLKRIVF

MAF1

186

Q9H063
KDNQDIYKRFLFHYS

NMS

61

Q5H8A3
FFLYKFCKSKERNYH

CD164

181

Q04900
YLKFLAFHYVSNRFK

SBF2

1496

Q86WG5
SLHKFSYKLEYLLQF

FYCO1

41

Q9BQS8
RFKYYLNKLHTFLSL

FAM135A

1341

Q9P2D6
TFHFLYFKDKIFNVA

FBXO3

381

Q9UK99
SFYFLHESLKNIYQF

INPP5A

106

Q14642
HKLYVLLFAKFFFLI

OR2M2

316

Q96R28
YLDFSLFKHRGFLIY

SLC16A7

236

O60669
IKNRKFHFPFYYLLA

LPAR3

56

Q9UBY5
SLFKNLFRNYNYKVH

LEPR

146

P48357
IHKFKYAFYLSCREL

NLRP2

236

Q9NX02
TGFKFLFTLFRKYYL

RALGAPA2

236

Q2PPJ7
NFFQKYKHYIVLLAS

PAPOLA

366

P51003
FFQKYRHYIVLTASA

PAPOLG

366

Q9BWT3
VVNTYFRHFKLYKYV

CFAP119

201

A1A4V9
YKFDDNYAFLHRTLK

APOBEC3F

171

Q8IUX4
YPHIFYFHFKNLRKA

APOBEC3F

196

Q8IUX4
YFHFKNLRKAYGRNE

APOBEC3F

201

Q8IUX4
FLLLTFADLKKYHFY

ATG7

131

O95352
FYATFLIQEYFRKFK

CACNA1C

1666

Q13936
IYNASLKKYFLITFF

G6PC1

201

P35575
FLKFFTYLHRLSCYQ

CORIN

171

Q9Y5Q5
FFSLFSRFIKAYKKA

FMNL1

986

O95466
SKFLFRKNYAKYEFF

GRB10

241

Q13322
KDYVFKLQFKSHVYF

FARP2

991

O94887
AYFYGFFKNKRIVLF

ZMPSTE24

266

O75844
FYATFLIQDYFRKFK

CACNA1D

1606

Q01668
HRLRKFYKPFNLMFY

HS3ST4

426

Q9Y661
KRFEKVYTHNLYYLA

KIFBP

201

Q96EK5
ISFGSLLYKYAFKFF

FANCD2

451

Q9BXW9
YFAKRFKRKNYHHSL

LRRN1

651

Q6UXK5
AAYFFYKKRRVHLPQ

MRC1

1406

P22897
LLRKYSFHKNIVSFY

NRK

96

Q7Z2Y5
LKFSVFYRNQHKEYF

PHYHIPL

181

Q96FC7
LFTERFHFYKRYTIK

UTP25

666

Q68CQ4
FHFYKRYTIKGIRNL

UTP25

671

Q68CQ4
FFLSSFLKQFKTKRY

SLC4A7

836

Q9Y6M7
FYAGYSLKRRHFFRN

SLC9A6

161

Q92581
VFTYFFKRTQYFRKN

SFXN4

266

Q6P4A7
YVHFLLNYRNKFKEQ

HMGB4

16

Q8WW32
ALKVIFYLDSYHFSK

PREX1

1436

Q8TCU6
KYFNKRKTYFAHDAL

MRPS17

41

Q9Y2R5
KFYLTYPTKRNEFHF

KCTD14

231

Q9BQ13
HISKDLYKSAFFYFE

SNAPC3

241

Q92966
LFESFKSYKGLFYFL

CLTCL1

701

P53675
KVHFFNSFFYDKLRT

SENP3

421

Q9H4L4
HLFALSTLYFYKFFL

TMEM31

126

Q5JXX7
FLAFQTSRYKLHYYE

TRAPPC1

61

Q9Y5R8
FSFLLSIFRSKYHGY

TUSC3

326

Q13454
TFKSYYLRNTFHKAL

TIGD1

341

Q96MW7
AAVREFYLSVYFFKK

WDR75

171

Q8IWA0
KYLYNFFLKDNSHVI

TBCK

576

Q8TEA7
YAKTENFKIAFYLSH

TLR7

961

Q9NYK1
FAFSKYQHKNLLILY

TNPO1

536

Q92973
LNTLFYFNTKYFGLK

ZMYM2

1216

Q9UBW7
AFYRFSYLTKHKIIH

ZNF430

381

Q9H8G1
FLFHISRLFYFSNEK

TRAM1

231

Q15629
YKVAFTKTFVQHYAF

UBR3

411

Q6ZT12
FTYQFLKKKFYIFSQ

WASHC4

841

Q2M389
FRFYRFALKEYIHFL

TRANK1

2256

O15050
FQQSHYFVALYRFKA

STAC3

246

Q96MF2
ISFKTYFSGNYFRHI

VASH1

191

Q7L8A9
KVAYFYCLSNNKHFL

ZFYVE26

321

Q68DK2
FAFRQTYEKFLHRYK

MYO1D

626

O94832
YGFQFKAFHFYLTRA

ART3

131

Q13508