Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.87e-1020425GO:0061665
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.16e-0836425GO:0019789
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.36e-0850425GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.57e-0853425GO:0016859
GeneOntologyMolecularFunctionGTPase activator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B RGPD3

2.42e-05279426GO:0005096
GeneOntologyMolecularFunctionisomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.97e-05192425GO:0016853
GeneOntologyMolecularFunctionenzyme activator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B FAM20A CTSV RGPD3

5.71e-05656428GO:0008047
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

1.73e-04398426GO:0061659
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.44e-04321425GO:0031267
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B RGPD3

6.28e-04507426GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B RGPD3

6.28e-04507426GO:0030695
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

6.61e-04512426GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

8.07e-04532426GO:0016755
GeneOntologyMolecularFunctionGTPase binding

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.11e-04360425GO:0051020
GeneOntologyMolecularFunctionacyltransferase activity

RGPD1 RGPD4 RGPD2 AMFR RANBP2 CPT1A RGPD3

1.06e-03775427GO:0016746
GeneOntologyMolecularFunctionmolecular function activator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B FAM20A CTSV RGPD3

3.72e-031233428GO:0140677
GeneOntologyMolecularFunctioncarboxypeptidase activity

AGBL4 CTSV

4.77e-0349422GO:0004180
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP6V0A1 KCNJ8

7.54e-0362422GO:0019829
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD1 RGPD4 RGPD2 RANBP2 TBC1D9B FAM20A CTSV RGPD3

8.55e-031418428GO:0030234
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.02e-129415GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.03e-1210415GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.07e-1113415GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-1114415GO:1903299
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.66e-1020415GO:0006607
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.15e-0838415GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

7.10e-0854415GO:0018208
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-0771415GO:0006111
GeneOntologyBiologicalProcessgluconeogenesis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.65e-06111415GO:0006094
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.15e-06115415GO:0019319
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.05e-06121415GO:0046364
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.20e-06132415GO:0043255
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.67e-06134415GO:0010906
GeneOntologyBiologicalProcessglucose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 CPT1A RGPD3

8.19e-06244416GO:0006006
GeneOntologyBiologicalProcessnucleobase-containing compound transport

RGPD1 RGPD4 RGPD2 RANBP2 SLC25A16 RGPD3

9.20e-06249416GO:0015931
GeneOntologyBiologicalProcessmRNA transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.79e-06145415GO:0051028
GeneOntologyBiologicalProcesshexose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 CPT1A RGPD3

1.94e-05284416GO:0019318
GeneOntologyBiologicalProcessRNA transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.43e-05175415GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.43e-05175415GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.64e-05178415GO:0051236
GeneOntologyBiologicalProcessmonosaccharide metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 CPT1A RGPD3

3.17e-05310416GO:0005996
GeneOntologyBiologicalProcessnuclear export

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.17e-05185415GO:0051168
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.08e-05195415GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.71e-05201415GO:0051170
GeneOntologyBiologicalProcessRNA localization

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.78e-05217415GO:0006403
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD1 RGPD4 RGPD2 RANBP2 LIMK2 RGPD3

7.50e-05362416GO:0034504
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.10e-05231415GO:0006109
GeneOntologyBiologicalProcessprotein folding

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.22e-04246415GO:0006457
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.25e-04247415GO:0016051
GeneOntologyBiologicalProcessregulation of small molecule metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 CPT1A RGPD3

2.02e-04434416GO:0062012
GeneOntologyBiologicalProcesscarbohydrate metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 GLB1L2 CPT1A RGPD3

2.55e-04646417GO:0005975
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

RGPD1 RGPD4 RGPD2 RANBP2 LIMK2 FAM20A RGPD3

7.87e-04780417GO:0042327
GeneOntologyBiologicalProcessnuclear transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.77e-04378415GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.77e-04378415GO:0006913
GeneOntologyBiologicalProcesspositive regulation of kinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.19e-03405415GO:0033674
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 LIMK2 FAM20A RGPD3

1.58e-03879417GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 LIMK2 FAM20A RGPD3

1.58e-03879417GO:0010562
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.82e-128445GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.17e-1210445GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.45e-1114445GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.74e-1018445GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.95e-1020445GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.48e-1021445GO:0106068
GeneOntologyCellularComponentinclusion body

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.26e-0690445GO:0016234
GeneOntologyCellularComponentnuclear pore

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.23e-06101445GO:0005643
GeneOntologyCellularComponentnuclear membrane

RGPD1 RGPD4 RGPD2 RANBP2 ARL6IP6 RETSAT RGPD3

7.67e-06349447GO:0031965
GeneOntologyCellularComponenttransferase complex

RGPD1 RGPD4 QTRT2 RGPD2 AMFR RANBP2 ANAPC1 KLHDC3 RGPD3

1.49e-04963449GO:1990234
GeneOntologyCellularComponentnuclear envelope

RGPD1 RGPD4 RGPD2 RANBP2 ARL6IP6 RETSAT RGPD3

1.55e-04560447GO:0005635
GeneOntologyCellularComponentorganelle envelope

RGPD1 RGPD4 QTRT2 RGPD2 RANBP2 ARL6IP6 CPT1A SLC25A16 RETSAT RGPD3

6.49e-0414354410GO:0031967
GeneOntologyCellularComponentperinuclear region of cytoplasm

RGPD1 RGPD4 RGPD2 AMFR RANBP2 LIMK2 ATP6V0A1 RGPD3

6.52e-04934448GO:0048471
GeneOntologyCellularComponentcation-transporting ATPase complex

ATP6V0A1 KCNJ8

4.78e-0349442GO:0090533
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.13e-1016355MP:0003701
MousePhenoabnormal morula morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.63e-0926355MP:0012058
MousePhenodecreased tumor latency

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.95e-0930355MP:0010308
MousePhenofailure of blastocyst formation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.18e-0831355MP:0012129
MousePhenoabnormal tumor latency

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.93e-0834355MP:0010307
MousePhenoabnormal blastocyst formation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.96e-0839355MP:0012128
MousePhenoincreased liver tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

2.94e-07111356MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

2.94e-07111356MP:0010297
MousePhenoaneuploidy

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.93e-0761355MP:0004024
MousePhenoabnormal rod electrophysiology

RGPD1 RGPD4 RGPD2 RANBP2 OTX2 RGPD3

4.45e-07119356MP:0004021
MousePhenoincreased hepatocellular carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

7.87e-0770355MP:0003331
MousePhenoincreased lung carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.35e-0678355MP:0008714
MousePhenoabnormal chromosome number

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.20e-0686355MP:0004023
MousePhenoincreased incidence of induced tumors

RGPD1 RGPD4 RGPD2 RANBP2 ADAM28 RGPD3

3.97e-06173356MP:0002021
MousePhenoenlarged epididymis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.41e-0699355MP:0004931
MousePhenoincreased tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 ADAM28 RGPD3

4.42e-06530359MP:0002020
MousePhenoincreased organ/body region tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 RGPD3

4.56e-06395358MP:0010274
MousePhenoabnormal organ/body region tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 RGPD3

5.10e-06401358MP:0013152
MousePhenoincreased sarcoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.11e-06102355MP:0002032
MousePhenoincreased lung tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.47e-06107355MP:0008014
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.47e-06107355MP:0003694
MousePhenoincreased respiratory system tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.47e-06107355MP:0010298
MousePhenoabnormal blastocyst hatching

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.45e-06113355MP:0003693
MousePhenoabnormal chromosome morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.44e-05126355MP:0003702
MousePhenoabnormal mitosis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.55e-05128355MP:0004046
MousePhenoabnormal tumor incidence

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 ADAM28 RGPD3

1.90e-05635359MP:0002019
MousePhenoabnormal eye electrophysiology

RGPD1 RGPD4 RGPD2 RANBP2 OTX2 RGPD3

1.93e-05228356MP:0005551
MousePhenosmall testis

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

2.26e-058233510MP:0001147
MousePhenoabnormal tumor susceptibility

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 ADAM28 RGPD3

2.29e-05650359MP:0002166
MousePhenoincreased incidence of tumors by chemical induction

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.47e-05141355MP:0004499
MousePhenoincreased classified tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 IKZF1 IKZF3 RGPD3

3.68e-05381357MP:0010273
MousePhenoabnormal classified tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 IKZF1 IKZF3 RGPD3

3.87e-05384357MP:0020188
MousePhenosmall gonad

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

4.22e-058853510MP:0001116
MousePhenodecreased susceptibility to diet-induced obesity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.54e-05160355MP:0005659
MousePhenoabnormal incidence of induced tumors

RGPD1 RGPD4 RGPD2 RANBP2 ADAM28 RGPD3

4.88e-05269356MP:0013151
MousePhenoabnormal primary sex determination

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

4.91e-059013510MP:0002211
MousePhenoabnormal epididymis size

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.41e-05166355MP:0004926
MousePhenoabnormal testis size

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

5.60e-059153510MP:0004849
MousePhenoabnormal preimplantation embryo development

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.23e-05171355MP:0009781
MousePhenoneoplasm

RGPD1 RGPD4 RGPD2 AMFR RANBP2 IKZF1 IKZF3 ADAM28 RGPD3

6.81e-05747359MP:0002006
MousePhenoincreased physiological sensitivity to xenobiotic

RGPD1 RGPD4 RGPD2 AMFR RANBP2 RGPD3

6.85e-05286356MP:0008873
MousePhenoabnormal sex determination

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

7.36e-059453510MP:0002210
MousePhenoabnormal cell nucleus morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.82e-05184355MP:0003111
MousePhenodecreased susceptibility to weight gain

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.28e-05186355MP:0010182
MousePhenoincreased energy expenditure

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.19e-04196355MP:0004889
MousePhenoincreased carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.22e-04197355MP:0002038
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.40e-04203355MP:0011094
MousePhenoimpaired glucose tolerance

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 GLB1L2 RGPD3

1.57e-04480357MP:0005293
MousePhenoabnormal male reproductive gland morphology

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV TMEM86A ZNF541 RGPD3

2.06e-0412903511MP:0013325
MousePhenoabnormal testis morphology

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV ZNF541 RGPD3

2.25e-0410813510MP:0001146
MousePhenoabnormal lymph node medulla morphology

IKZF1 CTSV

2.71e-0410352MP:0002348
MousePhenoincreased malignant tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.88e-04237355MP:0002018
MousePhenoembryonic lethality before implantation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.17e-04242355MP:0006204
MousePhenoabnormal intracellular organelle morphology

RGPD1 RGPD4 RGPD2 RANBP2 ATP6V0A1 CTSV RGPD3

3.46e-04546357MP:0014239
MousePhenoabnormal internal male genitalia morphology

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV TMEM86A ZNF541 RGPD3

4.01e-0413923511MP:0009205
MousePhenoabnormal male genitalia morphology

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV TMEM86A ZNF541 RGPD3

4.62e-0414153511MP:0009198
MousePhenoabnormal male reproductive system morphology

RGPD1 RGPD4 AP4E1 RGPD2 RANBP2 LIMK2 OTX2 CTSV TMEM86A ZNF541 RGPD3

4.62e-0414153511MP:0001145
MousePhenoaortic valve regurgitation

CTSV KCNJ8

4.67e-0413352MP:0006047
MousePhenoabnormal epididymis morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.14e-04269355MP:0002631
MousePhenoabnormal eye physiology

RGPD1 RGPD4 RGPD2 RANBP2 LIMK2 OTX2 RGPD3

6.47e-04606357MP:0005253
MousePhenoabnormal preimplantation embryo morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.48e-04283355MP:0014137
MousePhenoabsent mandible

OTX2 GLDC

8.09e-0417352MP:0000087
MousePhenosemilunar valve regurgitation

CTSV KCNJ8

9.09e-0418352MP:0006049
MousePhenoabnormal susceptibility to weight gain

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.62e-04309355MP:0011117
MousePhenoabnormal energy expenditure

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.02e-03313355MP:0005450
MousePhenoabnormal physiological response to xenobiotic

RGPD1 RGPD4 RGPD2 AMFR RANBP2 KIF26A RGPD3

1.09e-03662357MP:0008872
MousePhenoabnormal energy homeostasis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.16e-03322355MP:0005448
MousePhenodecreased CNS synapse formation

ATP6V0A1 IP6K3

1.36e-0322352MP:0004998
MousePhenoincreased central memory CD4-positive, alpha-beta T cell number

IKZF1 CTSV

1.62e-0324352MP:0010841
MousePhenoabnormal cell cycle

RGPD1 RGPD4 RGPD2 RANBP2 ZNF541 RGPD3

1.67e-03520356MP:0003077
MousePhenoincreased susceptibility to Herpesvirales infection induced morbidity/mortality

AGBL4 KCNJ8

1.76e-0325352MP:0031026
MousePhenoincreased spleen white pulp amount

IKZF1 GRK6

1.76e-0325352MP:0008478
MousePhenocardiac valve regurgitation

CTSV KCNJ8

1.91e-0326352MP:0009384
MousePhenoagnathia

OTX2 GLDC

2.06e-0327352MP:0030268
MousePhenoincreased pre-B cell number

IKZF1 IKZF3

2.37e-0329352MP:0003132
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell number

IKZF1 CTSV

2.54e-0330352MP:0012771
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell morphology

IKZF1 CTSV

2.54e-0330352MP:0010840
MousePhenoabnormal heart valve physiology

CTSV KCNJ8

2.54e-0330352MP:0011926
DomainRan_BP1

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.10e-1112415PF00638
DomainRANBD1

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.10e-1112415PS50196
DomainRanBD

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.03e-1113415SM00160
DomainRan_bind_dom

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.03e-1113415IPR000156
DomainGCC2_Rab_bind

RGPD1 RGPD4 RGPD2 RGPD3

6.96e-107414IPR032023
DomainRab_bind

RGPD1 RGPD4 RGPD2 RGPD3

6.96e-107414PF16704
Domain-

RGPD1 RGPD4 RGPD2 RGPD3

4.16e-09104141.10.220.60
DomainGRIP

RGPD1 RGPD4 RGPD2 RGPD3

6.52e-0911414PF01465
DomainGrip

RGPD1 RGPD4 RGPD2 RGPD3

6.52e-0911414SM00755
DomainGRIP_dom

RGPD1 RGPD4 RGPD2 RGPD3

9.77e-0912414IPR000237
DomainGRIP

RGPD1 RGPD4 RGPD2 RGPD3

9.77e-0912414PS50913
DomainTPR

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.93e-06129415SM00028
DomainTPR_repeat

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.04e-05133415IPR019734
DomainTPR-contain_dom

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.86e-05150415IPR013026
DomainTPR

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.93e-05165415PS50005
DomainTPR_REGION

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.93e-05165415PS50293
Domain-

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.63e-052074151.25.40.10
DomainTPR-like_helical_dom

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.50e-04233415IPR011990
Domain-

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.58e-033914152.30.29.30
DomainPH_dom-like

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.30e-03426415IPR011993
DomainZnf_CCCH

ZC3H12B PAN3

7.19e-0358412IPR000571
DomainZF_C3H1

ZC3H12B PAN3

7.19e-0358412PS50103
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.29e-1018335MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.18e-0840335MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.61e-0841335MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.10e-0842335MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.63e-0843335MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

7.32e-0847335MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.08e-0849335MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.01e-0750335MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.11e-0751335MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.64e-0755335MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.15e-0758335MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.15e-0758335MM14736
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

2.65e-07117336MM15387
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.83e-0765335MM15147
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.87e-0773335MM14948
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.23e-0682335MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.39e-0684335MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.56e-0686335MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.18e-0692335MM14951
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.29e-06100335MM14561
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

4.96e-06193336MM14890
PathwayREACTOME_MITOTIC_PROPHASE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.27e-06114335MM15361
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.15e-05129335MM14894
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

1.49e-05234336MM14898
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.77e-05141335MM15266
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

3.42e-05271336MM15388
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD1 RGPD4 RGPD2 RANBP2 GLB1L2 RGPD3

3.42e-05271336MM15406
PathwayREACTOME_SUMOYLATION

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.22e-05169335MM14919
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.84e-05202335MM15362
PathwayREACTOME_M_PHASE

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

2.43e-04387336MM15364
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.03e-04257335MM14755
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.27e-04277335MM15414
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

9.96e-04505336MM15548
PathwayREACTOME_CELL_CYCLE

RGPD1 RGPD4 RGPD2 RANBP2 ANAPC1 RGPD3

2.47e-03603336MM14635
PathwayREACTOME_METABOLISM_OF_RNA

RGPD1 RGPD4 RGPD2 RANBP2 PAN3 RGPD3

2.66e-03612336MM15547
PathwayKEGG_LYSOSOME

AP4E1 ATP6V0A1 CTSV

2.79e-03121333M11266
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743530944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743538838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743521205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743518949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743525187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-1474359037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743523536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-1474358603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-1474357559465
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743526632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743517372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743524403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743523818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743538657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743511353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743512191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743522821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.76e-14743520682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-13843522262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-13843521670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-13843528745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-13843527412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-13843521310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-1394359733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943528100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943518394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943528877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943511553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943517887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.85e-13943510601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.70e-131043527160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.70e-131043516332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.70e-13104358857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.70e-131043521859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.04e-121143535771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.04e-121143517069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.04e-121143534110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

2.90e-121343531427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.76e-121543514697343
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.89e-112243527717094
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD1 RGPD4 RGPD2 RGPD3

7.07e-11743415710750
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.11e-093843512791264
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

7.35e-088643537253089
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.49e-079943527746211
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

RGPD1 RGPD4 RGPD2 RANBP2 IKZF1 IKZF3 RGPD3

3.38e-0737043722922362
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.99e-0713543531077711
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD1 RGPD4 RGPD2 RANBP2 ZNF318 ANAPC1 RGPD3

7.65e-0741843734709266
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.03e-0614643523892456
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.30e-0615343526365490
Pubmed

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.

IKZF1 IKZF3

1.49e-0624329155026
Pubmed

IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.

IKZF1 IKZF3

1.49e-06243231558666
Pubmed

Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1/NK cell transdifferentiation.

IKZF1 IKZF3

1.49e-06243231151137
Pubmed

A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.

IKZF1 IKZF3

1.49e-06243234155405
Pubmed

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.

IKZF1 IKZF3

1.49e-06243237662955
Pubmed

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.

IKZF1 IKZF3

1.49e-06243233182226
Pubmed

Critical function of Ikaros in controlling Aiolos gene expression.

IKZF1 IKZF3

1.49e-06243217383641
Pubmed

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide.

IKZF1 IKZF3

1.49e-06243227881177
Pubmed

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

IKZF1 IKZF3

1.49e-06243224509510
Pubmed

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.

IKZF1 IKZF3

1.49e-06243233499314
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

RGPD1 RGPD4 RGPD2 RANBP2 IKZF1 IKZF3 CPT1A RGPD3

2.04e-0670143830196744
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF1 IKZF3

4.48e-06343220432734
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF1 IKZF3

4.48e-06343227502439
Pubmed

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

IKZF1 IKZF3

4.48e-06343212504015
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF1 IKZF3

4.48e-06343211937265
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF1 IKZF3

4.48e-0634329560339
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF1 IKZF3

4.48e-06343218332232
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD1 RGPD4 RGPD2 PAN3 RGPD3

6.85e-0621543535973513
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

8.72e-0622643537839992
Pubmed

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

IKZF1 IKZF3

8.94e-06443224292623
Pubmed

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

IKZF1 IKZF3

8.94e-06443224328678
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

9.70e-0623143516452087
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF1 IKZF3

1.49e-05543210978333
Pubmed

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.

IKZF1 IKZF3

1.49e-05543210766745
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

RGPD1 RGPD4 RGPD2 RANBP2 RETSAT RGPD3

1.67e-0544243615815621
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

IKZF1 LIMK2 IKZF3 ANAPC1

1.99e-0512943423022380
Pubmed

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression.

IKZF1 IKZF3

2.23e-05643220566697
Pubmed

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.

IKZF1 IKZF3

3.12e-05743226823144
Pubmed

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

IKZF1 IKZF3

3.12e-05743210357820
Pubmed

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

IKZF1 IKZF3

5.35e-05943219734904
Pubmed

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

ATP6V0A1 CTSV

6.68e-051043220541250
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

IKZF1 IKZF3

8.15e-051143210204490
Pubmed

The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.

OTX2 CTSV

9.78e-05124329096102
Pubmed

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

AMFR RANBP2 ATP6V0A1 CPT1A RETSAT

1.20e-0439243533144569
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RGPD1 RGPD4 QTRT2 RGPD2 RANBP2 CPT1A ANAPC1 RGPD3

1.34e-04125743837317656
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

IKZF1 IKZF3

1.35e-041443212015313
Pubmed

Ikaros family proteins redundantly regulate temporal patterning in the developing mouse retina.

IKZF1 OTX2

1.35e-041443236537580
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

RGPD1 RGPD4 RGPD2 AMFR RANBP2 TBC1D9B

1.37e-0464743626618866
Pubmed

A conserved regulatory logic controls temporal identity in mouse neural progenitors.

IKZF1 OTX2

1.55e-041543225654255
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD1 RGPD4 RGPD2 RANBP2 ZNF318 ANAPC1 RGPD3

1.65e-0496343728671696
Pubmed

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

IKZF1 IKZF3

1.77e-041643230760870
Pubmed

AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.

RANBP2 IKZF1

2.01e-041743232391793
Pubmed

Ikaros SUMOylation: switching out of repression.

IKZF1 IKZF3

2.01e-041743215767674
Pubmed

Ikaros promotes early-born neuronal fates in the cerebral cortex.

IKZF1 IKZF3

2.52e-041943223382203
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

AP4E1 TMEM131L RANBP2 ZNF318

3.13e-0426343434702444
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TMEM131L TLCD1 ZNF318 GLB1L2 PAN3 KLHDC3 KCNJ8

3.39e-04108443711544199
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RGPD1 RGPD4 RGPD2 RANBP2 ZNF318 GRK6 ZNF541 RGPD3

3.40e-04144243835575683
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

RGPD1 RGPD2 RANBP2 ZNF318

3.50e-0427143432433965
Pubmed

Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.

IKZF1 OTX2

4.76e-042643232071204
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

RGPD1 RGPD4 RGPD2 RANBP2 ZNF318 RGPD3

5.69e-0484443625963833
Pubmed

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.

IKZF1 IKZF3

6.35e-043043224292625
InteractionRGPD4 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

6.11e-1022405int:RGPD4
InteractionRGPD2 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.86e-0927405int:RGPD2
InteractionRGPD3 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.43e-0847405int:RGPD3
InteractionRGPD1 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

4.25e-0849405int:RGPD1
InteractionRGPD8 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

3.46e-0774405int:RGPD8
InteractionRGPD5 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.27e-0696405int:RGPD5
InteractionICOSLG interactions

TMEM131L AMFR RETSAT

8.07e-0620403int:ICOSLG
Cytoband2p11.2

RGPD1 RGPD2 RETSAT

3.28e-05644432p11.2
Cytoband2q12.3

RGPD4 RANBP2

1.21e-04174422q12.3
CytobandEnsembl 112 genes in cytogenetic band chr2p11

RGPD1 RGPD2 RETSAT

1.13e-03213443chr2p11
CytobandEnsembl 112 genes in cytogenetic band chr2q13

RANBP2 ANAPC1

1.48e-0359442chr2q13
Cytoband17q21

IKZF3 ATP6V0A1

1.69e-036344217q21
CytobandEnsembl 112 genes in cytogenetic band chr2q12

RGPD4 RGPD3

2.84e-0382442chr2q12
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

5.64e-07115265769
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD1 RGPD4 RGPD2 RANBP2 ATP6V0A1 RGPD3

6.80e-1143426MM3857
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD1 RGPD4 RGPD2 RANBP2 RGPD3

1.90e-0933425MM477
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RGPD1 RGPD4 RGPD2 RANBP2 ZNF318 ADAM28 RGPD3

9.44e-06474427M40991
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

RGPD1 RGPD4 RGPD2 RANBP2 IKZF1 RGPD3

6.39e-05435426MM1221
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D

RGPD1 RGPD4 QTRT2 RGPD2 RANBP2 LIMK2 CPT1A RGPD3

7.14e-05888428MM1315
CoexpressionAtlasMesoderm Day 5_vs_Mesoderm Day 15-Confounder_removed-fold2.0_adjp0.05

RGPD4 GMPR ARL6IP6 OTX2 PAN3 SLC35F3 FAM20A KIF26A CTSV GRK6 RGPD3

2.10e-0512764111PCBC_ratio_MESO-5_vs_MESO-15_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

RGPD4 AMFR GMPR TBC1D9B ARL6IP6 OTX2 SLC35F3 FAM20A CTSV RGPD3

5.13e-0511534110PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

TMEM131L IKZF1 ZNF318 IKZF3 ADAM28

8.30e-07176445d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|368C / Donor, Lineage, Cell class and subclass (all cells)

IKZF3 GLB1L2 SLC25A16 CTSV

1.34e-051474443ed5b020ce1f1277917d79ef1f7da53fa474e8db
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RGPD1 TMEM131L RGPD2 RGPD3

1.57e-051534447480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RGPD1 TMEM131L RGPD2 RGPD3

1.69e-0515644453ded973358e3e48054130131e959f0d1f4ef60f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.11e-051654447039bb5a7af4684fbd1192230864e5cd6936e83c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.11e-05165444d2c79653710b139794170f3d72f11392fc548ac7
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

TMEM131L IKZF1 IKZF3 ADAM28

2.27e-05168444a7159a35fe37f8c241cf8d391debe271e0698105
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.37e-05170444a965e3ee6818790a4a6916824fde64333d9b11b7
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMEM131L IKZF1 IKZF3 ADAM28

2.43e-051714448e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.72e-05176444d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.72e-05176444274458d80f9f3f080248cbf64e4784ef351e7254
ToppCellCOVID-19-lung-B_cells|lung / Disease (COVID-19 only), tissue and cell type

TMEM131L IKZF1 IKZF3 ADAM28

2.78e-05177444f54691e5558091c1734ab15153a10bff15ed171e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.78e-05177444b07e6139618d888a9fd7cf43cad0d86a3f63e09e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.78e-051774446376ec12322c04d5d37ec2fdc376700464cbc7fb
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

TMEM131L IKZF1 IKZF3 ADAM28

2.78e-05177444653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellChildren_(3_yrs)-Immune-B_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM131L IKZF1 IKZF3 ADAM28

2.90e-0517944431411780f1a44bf2d102f288416e97eacec4b6b6
ToppCellCOVID-19-kidney-Bcells|kidney / Disease (COVID-19 only), tissue and cell type

TMEM131L IKZF1 IKZF3 ADAM28

2.97e-051804445650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGPD2 IKZF1 IKZF3 RGPD3

2.97e-05180444702673c0b7c5b0d22a6af3884374804b8c4d6254
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

2.97e-0518044465c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

3.23e-05184444f81209e6bc01a0140f4487aa8b22eb02fbf0c39c
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMEM131L IKZF1 IKZF3 ADAM28

3.30e-05185444e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellChildren_(3_yrs)-Immune-B_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMEM131L IKZF1 IKZF3 ADAM28

3.37e-05186444aa576748921a318798b911a611f05319b95e8d5e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

3.44e-05187444edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L IKZF1 IKZF3 ADAM28

3.44e-051874448fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCellImmune-B_cell|World / Lineage, Cell type, age group and donor

TMEM131L IKZF1 IKZF3 ADAM28

3.44e-05187444795690c6306c366e733279491138d0cd9b469b21
ToppCellbackground-B_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

IKZF1 ZNF318 IKZF3 ADAM28

3.52e-051884449acb7a95e3095f15918a5d094107d1d565a42842
ToppCellFetal_29-31_weeks-Immune-B_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMEM131L RGPD2 IKZF1 IKZF3

3.67e-05190444424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L IKZF1 IKZF3 GRK6

3.82e-051924442de242d81dc085ae734eb7d1f091af9a542e0866
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

AGBL4 GLB1L2 SLC35F3 GLDC

3.82e-05192444d3634574b2e8d2ded6446969361b70761b331aea
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L IKZF1 IKZF3 GRK6

3.82e-05192444ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IKZF1 IKZF3 GLDC ADAM28

4.14e-05196444fc67d8aad1ec4d7f98ffe44fb103e230b9b42c35
ToppCell3'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IKZF1 IKZF3 SLC15A1 ADAM28

4.22e-051974441614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IKZF1 IKZF3 GLDC ADAM28

4.22e-051974440f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RGPD1 IKZF1 GLDC ADAM28

4.22e-05197444749e0e332644543cbdf2ee38c2b301ce0a019a7f
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RGPD2 IKZF1 IKZF3 GLDC

4.39e-051994441bb02f41f3cc76a28581e38b0ca4c36b930b85b4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

SERTM2 GMPR IKZF1 ADAM28

4.48e-05200444fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIMK2 IP6K3 SLC15A1

2.15e-041184436053e19d040fb394f9c270361af07b0c5a4d47db
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LIMK2 IP6K3 SLC15A1

2.15e-04118443811e8521129914eef46785a4227c1860e77d9096
ToppCellMild/Remission-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TMEM131L ZNF318 KCNJ8

2.32e-0412144368940a552233d255b90ce5a081339c0d9d46ab02
ToppCellCOVID-19-B_cells-B_cells|COVID-19 / group, cell type (main and fine annotations)

TMEM131L IKZF3 ADAM28

2.86e-04130443267b06a0db31e2664cf595cd737402da07ab51cd
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM131L ZNF318 ADAM28

2.93e-04131443a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF1 IKZF3 GRK6

3.48e-04139443ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RGPD4 TMEM131L ZNF318

3.78e-04143443bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RGPD2 IKZF1 IKZF3

4.35e-0415044317da17f01a3d41ac7df20f806e3eae30eca06982
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RGPD2 IKZF1 IKZF3

4.35e-041504438b781ec3e6c2adf052d46d724e2aef72b0c27d13
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RGPD2 IKZF1 IKZF3

4.35e-041504438702d5bb419d5e997d388e8f7e0365ba5d1de8d5
ToppCellInt-URO-Other|Int-URO / Disease, Lineage and Cell Type

TLCD1 SLC35F3 TMEM86A

4.44e-04151443ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAM20A KIF26A GLDC

4.44e-0415144310da94037225a71844281ddcb395072250a78094
ToppCellInt-URO-Other-RBC|Int-URO / Disease, Lineage and Cell Type

TLCD1 SLC35F3 TMEM86A

4.44e-041514430344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.61e-0415344395b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF1 CPT1A GRK6

4.61e-04153443c4dcdcaa672929c1da870e9fb8ada1bb030ad12f
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.61e-04153443b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.61e-041534433ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GLB1L2 SLC25A16 CTSV

4.70e-04154443ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCellAdult-Immune-B_cell-D122|Adult / Lineage, Cell type, age group and donor

IKZF3 GLDC ADAM28

4.79e-041554435857aebd43b901fc9f8c46f2d628582969db9e6a
ToppCellfacs-Liver-Hepatocytes|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLCD1 RETSAT GLDC

4.88e-04156443e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCellfrontal_cortex-Non-neuronal-astrocyte|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.97e-04157443803af734d7f775d294391e2b84e472a732e18cef
ToppCellfrontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.97e-041574439aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCellfrontal_cortex-Non-neuronal-astrocyte-Astro|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TLCD1 FAM20A GLDC

4.97e-041574430551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 CTSV

5.06e-041584432cfa6dd36c8ae534cf1dd49366d4b4433388c1e0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 CTSV

5.06e-041584430c9bb7f8d080a052ca71701544a076c6c2ea67cd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 CTSV

5.06e-04158443cebb58878b6945074bc1c7d5848d842da5dcbae1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IKZF1 IKZF3 CPT1A

5.16e-04159443bf8ff9251bcb64b2b9d6dd93461aec97659686ec
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CTSV TMEM86A ADAM28

5.16e-041594436115cb03c2ad08e4c1b65893d522f685ff0bc692
ToppCellBronchial_Brush-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ARL6IP6 OTX2 TMEM86A

5.16e-0415944395834b767cfb4fb8c5aeea89c10f3e14a1fd15c1
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IKZF1 IKZF3 KCNJ8

5.25e-04160443e4516b093003275084fc327d1597394a436754eb
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CTSV TMEM86A ADAM28

5.25e-04160443a90eb621481fd07a821495db07d1032e109fd386
ToppCellfacs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IKZF1 IKZF3 KCNJ8

5.25e-041604430a507e3d59d7f744d0201a531ea84fa97a68aedb
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LIMK2 GLB1L2 ADAM28

5.35e-041614432d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF1 IKZF3 KCNJ8

5.45e-0416244366069146e2666d13c594bd76247893354a697c5d
ToppCellAdult-Immune-B_cell-D231|Adult / Lineage, Cell type, age group and donor

RGPD2 IKZF3 ADAM28

5.54e-041634434f5821299b265663c7d0352b28285f56e1988841
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF1 IKZF3 KCNJ8

5.64e-04164443e9e5a1462d8ed60b2e5bf603c8c47eb85bce83d5
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF1 IKZF3 KCNJ8

5.64e-041644431a9b444d2c6abcc83d4355ec5228b27541df2bd0
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMEM131L ZNF318 ADAM28

5.74e-04165443fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCellfacs-Kidney-nan-3m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF1 PAN3 GRK6

5.74e-04165443ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCellfacs-Trachea-nan-18m-Epithelial-mucus_secreting_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMPR SLC15A1 KIF26A

5.74e-041654437e7643834ed483aec04f513cca38d6367fda9ff8
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF1 IKZF3 KCNJ8

5.85e-041664430b7503e27e26dcbf7f1b893c32ce0b21ce58bd4a
ToppCellAdult-Immune-natural_killer_cell-D122|Adult / Lineage, Cell type, age group and donor

IKZF1 IKZF3 GLB1L2

5.95e-04167443ff1ce3b1a2d91d2ad979f25899db4f4eeb865892
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V0A1 IP6K3 ADAM28

5.95e-0416744302c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 IKZF3 GRK6

6.05e-04168443784ce773521e5d74570f45120e56d112bc76ff49
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM131L IKZF1 IKZF3

6.16e-04169443203971cceeba150d0e8891c92662545e84c77837
ToppCellSevere-Lymphoid-T-|Severe / Condition, Lineage, Cell class and cell subclass

RGPD4 IKZF1 IKZF3

6.26e-041704435788e1158fde036937d41708e9db3222ca351eb1
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

IKZF3 GLDC ADAM28

6.26e-04170443e421f9eedf74baffda1d03707a710ece4b777f29
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 IKZF3 GRK6

6.26e-041704437a4ed69c807c3761210776e8fe6680d1bd892e82
ToppCellfacs-Heart-LV-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L ZNF318 IKZF3

6.37e-0417144355b194a9bf4d3e4b5d96e0d1298424359c441cbb
ToppCellImmune-dendritic_cell|World / Lineage, Cell type, age group and donor

IKZF1 SLC35F3 ADAM28

6.37e-041714436a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RGPD1 IP6K3 ADAM28

6.37e-0417144325c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RGPD1 TMEM131L ZNF318

6.37e-04171443d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCellCOVID-19-kidney-Plasma|kidney / Disease (COVID-19 only), tissue and cell type

IKZF1 IKZF3 ADAM28

6.37e-04171443a59a054b8e119215f24dc5c80ad5a8094b3500f9
ToppCellfacs-Heart-LV-3m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM131L ZNF318 IKZF3

6.37e-04171443c6fc9ef9735dbf5314a4c7dac2b2954b0985ae4d
ToppCellChildren_(3_yrs)-Immune-dendritic_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

IKZF1 SLC35F3 ADAM28

6.37e-041714436a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RGPD1 IP6K3 ADAM28

6.37e-04171443fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

GMPR IKZF1 IKZF3

6.48e-041724436e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 ADAM28

6.59e-0417344362ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 IKZF3 SLC35F3

6.70e-0417444301eff218e71a04201189a0313aaf91437fffed95
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 IKZF3 SLC35F3

6.70e-04174443f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 ADAM28

6.70e-041744431b2a2129c08bac01fc638692313b196759a1e0d7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AMFR GMPR SLC35F3

6.70e-041744435f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 IKZF3 SLC35F3

6.70e-041744432f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IKZF1 IKZF3 ADAM28

6.70e-041744435bde24eb588dc588efc413811379548120ec0c7f
Diseasealcohol and nicotine codependence

RGPD1 RGPD2

1.25e-0413382EFO_0004776
DiseaseGastro-enteropancreatic neuroendocrine tumor

IKZF1 IKZF3

1.68e-0415382C2930967
Diseaseeosinophil percentage of granulocytes

IKZF1 LIMK2 IKZF3 ANAPC1

2.30e-04234384EFO_0007996
Diseasetaurine measurement

SLC35F3 GRK6

5.15e-0426382EFO_0010536
DiseaseL2 Acute Lymphoblastic Leukemia

IKZF1 IKZF3

1.90e-0350382C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

IKZF1 IKZF3

2.06e-0352382C0023452
Diseaseasthma

IKZF1 IKZF3 ATP6V0A1 IP6K3 GLDC

2.64e-03751385MONDO_0004979
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF1 IKZF3

2.82e-0361382C1961102
Diseaseneutrophil percentage of granulocytes

IKZF1 LIMK2 IKZF3

3.15e-03228383EFO_0007994
Diseasehistidine measurement

ARL6IP6 GRK6

3.29e-0366382EFO_0009769
Diseasebasophil count, eosinophil count

IKZF1 LIMK2 ANAPC1

3.68e-03241383EFO_0004842, EFO_0005090
DiseaseCleft palate

SLC15A1 ADAM28

3.79e-0371382HP_0000175
Diseaseotosclerosis

IP6K3 ANAPC1

4.91e-0381382EFO_0004213

Protein segments in the cluster

PeptideGeneStartEntry
MGHNFGMFHDDYSCK

ADAM28

341

Q9UKQ2
YSQGKHGFTMAMNAF

CTSV

66

O60911
SYHGWMFTEHGKMSR

CPT1A

131

P50416
GNLTGFISYHMMDTH

AP4E1

1001

Q9UPM8
LTMRDTMKYVYGHHG

SLC25A16

281

P16260
TFLEMKGHFYMHAGS

RANBP2

281

P49792
KGHFYMHAGSLLLKM

RANBP2

286

P49792
FLHMKTGGEMNYGFH

ANAPC1

1541

Q9H1A4
FAHGDIYAYMEKSGM

KCNJ8

96

Q15842
FAKGIASGMAYLHSM

LIMK2

431

P53671
FSFGHMSLGKSYTMI

KIF26A

466

Q9ULI4
MMGFAGIHEAHLLFF

OR6Q1

16

Q8NGQ2
MYTIHMGCHGFRDPF

IKZF1

476

Q13422
FLHQVGGHMSVMKYD

IP6K3

21

Q96PC2
SVMHFGMSGFDAHTL

OOSP4B

106

A0A2R8Y4Y8
VFAYDFHAGGETMMS

PAN3

566

Q58A45
GVLLMMHNFEHYFGF

QTRT2

376

Q9H974
ATFLEMKGHFYMHAG

RGPD3

281

A6NKT7
MKGHFYMHAGSLLLK

RGPD3

286

A6NKT7
DIHAHSTMMNGFMYG

AGBL4

326

Q5VU57
DFHSATMLGSHMYVF

KLHDC3

181

Q9BQ90
HSLYGGYMMSHQFSS

KLF18

911

A0A0U1RQI7
TNFGFMNGAMHFHDY

GLB1L2

321

Q8IW92
MNGAMHFHDYKSDVT

GLB1L2

326

Q8IW92
FYGMSSDTAMNKHAG

GMPR

266

P36959
HFHYVLSMGAVFAIM

MT-CO1

376

P00395
MNGGDLKFHIYHMGQ

GRK6

266

P43250
FLDYVMFTIHMGCHG

IKZF3

461

Q9UKT9
MGMSKSHSFFGYPLS

SLC15A1

1

P46059
SATFLEMKGHFYMHA

RGPD1

271

P0DJD0
EMKGHFYMHAGSLLL

RGPD1

276

P0DJD0
FYMHAGSLLLKMGQH

RGPD1

281

P0DJD0
FGGMDCGSYLTPMHH

OTX2

196

P32243
SMHALLVNHYMKGGF

RETSAT

276

Q6NUM9
ATFLEMKGHFYMHAG

RGPD4

281

Q7Z3J3
MKGHFYMHAGSLLLK

RGPD4

286

Q7Z3J3
MMEAHFKYHGNLTGR

SERTM2

1

A0A1B0GWG4
VIAHCGMHYFMGKSK

TMEM131L

501

A2VDJ0
TFLEMKGHFYMHAGS

RGPD2

281

P0DJD1
KGHFYMHAGSLLLKM

RGPD2

286

P0DJD1
IGNMDRHHYEMFTKF

FAM20A

406

Q96MK3
AGIVMMTYADGFHSH

SLC35F3

216

Q8IY50
FKEFVTGMSGMYHGD

TBC1D9B

901

Q66K14
ITGYTHGMHTLAFMA

AMFR

206

Q9UKV5
KKLTGHSFHMGYSMA

ARL6IP6

196

Q8N6S5
HSFHMGYSMAILNGI

ARL6IP6

201

Q8N6S5
GYFVHGLLMFAVTHM

TMEM86A

91

Q8N2M4
KFESMGDHGYYSMLG

ZC3H12B

536

Q5HYM0
VHHVMAMGAFFSGIF

TLCD1

116

Q96CP7
MFGDFGHGILMTLFA

ATP6V0A1

406

Q93050
GTMFDFFTHMHNKKH

ZNF318

1076

Q5VUA4
MFYTEKGLSSHMCFH

ZNF541

846

Q9H0D2
MAAMFAIYHGSHGLE

GLDC

391

P23378