Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	D-mannose binding	MRC1 IGF2R LMAN2	3.67e-04	27	104	3	GO:0005537
GeneOntologyMolecularFunction	ferroxidase activity	CP HEPH	3.98e-04	6	104	2	GO:0004322
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, oxygen as acceptor	CP HEPH	3.98e-04	6	104	2	GO:0016724
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDKL3 CDKL5 CDK7	5.03e-04	30	104	3	GO:0004693
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDKL3 CDKL5 CDK7	5.03e-04	30	104	3	GO:0097472
GeneOntologyBiologicalProcess	positive regulation of dendrite morphogenesis	ILK CDKL3 LRP8 CDKL5 PTPRF	1.84e-05	67	100	5	GO:0050775
GeneOntologyBiologicalProcess	positive regulation of cell morphogenesis	ILK CDKL3 LRP8 CDKL5 PTPRF	2.13e-05	69	100	5	GO:0010770
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	7.05e-05	3	102	2	GO:0043291
GeneOntologyCellularComponent	cell surface	CFH MRC1 IL13RA1 STAB2 NTRK2 LAG3 TECTB CP CUBN LRP8 IGF2R CD5L CD63 LMAN2 PRLR IGSF3	9.23e-05	1111	102	16	GO:0009986
GeneOntologyCellularComponent	synaptic membrane	NTRK2 KCNAB2 CSMD2 TENM2 CHRNB3 LRP8 NTNG2 PTPRF ITSN2 ADGRL2 SEZ6L	1.30e-04	583	102	11	GO:0097060
GeneOntologyCellularComponent	postsynaptic membrane	NTRK2 KCNAB2 CSMD2 TENM2 CHRNB3 LRP8 PTPRF ADGRL2 SEZ6L	1.65e-04	405	102	9	GO:0045211
GeneOntologyCellularComponent	platelet dense granule membrane	LAMP2 CD63	3.49e-04	6	102	2	GO:0031088
Domain	FAM47	FAM47A FAM47C FAM47B	6.49e-07	4	103	3	PF14642
Domain	FAM47	FAM47A FAM47C FAM47B	6.49e-07	4	103	3	IPR032743
Domain	Rav1p_C	DMXL2 DMXL1	3.01e-05	2	103	2	IPR022033
Domain	Rav1p_C	DMXL2 DMXL1	3.01e-05	2	103	2	PF12234
Domain	EGF	STAB2 CUBN PTGS2 LRP8 NTNG2 HMCN1	7.01e-05	126	103	6	PF00008
Domain	MULTICOPPER_OXIDASE2	CP HEPH	9.00e-05	3	103	2	PS00080
Domain	Cu-oxidase	CP HEPH	9.00e-05	3	103	2	PF00394
Domain	Cu-oxidase	CP HEPH	9.00e-05	3	103	2	IPR001117
Domain	WD_REPEATS_1	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1 NBAS	1.53e-04	278	103	8	PS00678
Domain	WD_REPEATS_2	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1 NBAS	1.57e-04	279	103	8	PS50082
Domain	WD_REPEATS_REGION	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1 NBAS	1.57e-04	279	103	8	PS50294
Domain	PPR	DENND4A DENND4C	1.79e-04	4	103	2	PF01535
Domain	Cu-oxidase_2	CP HEPH	1.79e-04	4	103	2	IPR011706
Domain	Cu-oxidase_2	CP HEPH	1.79e-04	4	103	2	PF07731
Domain	Quino_amine_DH_bsu	TEP1 TENM2 NBAS	2.32e-04	22	103	3	IPR011044
Domain	Cu-oxidase_3	CP HEPH	2.98e-04	5	103	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	CP HEPH	2.98e-04	5	103	2	PS00079
Domain	Cu_oxidase_CS	CP HEPH	2.98e-04	5	103	2	IPR033138
Domain	Cu-oxidase_3	CP HEPH	2.98e-04	5	103	2	PF07732
Domain	CTDL_fold	COL4A2 MRC1 STAB2 REG4 KLRG1	3.15e-04	107	103	5	IPR016187
Domain	EGF	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	3.25e-04	235	103	7	SM00181
Domain	EGF_3	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	3.25e-04	235	103	7	PS50026
Domain	Cu_oxidase_Cu_BS	CP HEPH	4.45e-04	6	103	2	IPR002355
Domain	EGF-like_dom	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	4.60e-04	249	103	7	IPR000742
Domain	-	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1 NBAS	5.14e-04	333	103	8	2.130.10.10
Domain	EGF_1	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	5.30e-04	255	103	7	PS00022
Domain	WD40/YVTN_repeat-like_dom	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1 NBAS	5.34e-04	335	103	8	IPR015943
Domain	EGF_CA	STAB2 CUBN TENM2 LRP8 HMCN1	5.75e-04	122	103	5	SM00179
Domain	EGF-like_CS	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	6.08e-04	261	103	7	IPR013032
Domain	EGF-like_Ca-bd_dom	STAB2 CUBN TENM2 LRP8 HMCN1	6.20e-04	124	103	5	IPR001881
Domain	EGF_2	STAB2 CUBN TENM2 PTGS2 LRP8 NTNG2 HMCN1	6.65e-04	265	103	7	PS01186
Domain	WD40	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1	7.11e-04	268	103	7	SM00320
Domain	WD40_repeat	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1	7.76e-04	272	103	7	IPR001680
Domain	PPR	DENND4A DENND4C	8.25e-04	8	103	2	PS51375
Domain	WD40_repeat_dom	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1	1.29e-03	297	103	7	IPR017986
Domain	GFP-like	STAB2 HMCN1	1.60e-03	11	103	2	IPR023413
Domain	-	STAB2 HMCN1	1.60e-03	11	103	2	2.40.155.10
Domain	EGF_dom	STAB2 CUBN	1.92e-03	12	103	2	IPR024731
Domain	EGF_3	STAB2 CUBN	1.92e-03	12	103	2	PF12947
Domain	-	MRC1 STAB2 REG4 KLRG1	2.04e-03	97	103	4	3.10.100.10
Domain	C-type_lectin-like/link	MRC1 STAB2 REG4 KLRG1	2.20e-03	99	103	4	IPR016186
Domain	-	MRC1 IGF2R	2.26e-03	13	103	2	2.10.10.10
Domain	CUB	CUBN CSMD2 SEZ6L	2.50e-03	49	103	3	PF00431
Domain	FN_type2_col-bd	MRC1 IGF2R	2.62e-03	14	103	2	IPR000562
Domain	FN2_2	MRC1 IGF2R	2.62e-03	14	103	2	PS51092
Domain	FN2_1	MRC1 IGF2R	2.62e-03	14	103	2	PS00023
Domain	-	CP HEPH	2.62e-03	14	103	2	2.60.40.420
Domain	fn2	MRC1 IGF2R	2.62e-03	14	103	2	PF00040
Domain	FN2	MRC1 IGF2R	2.62e-03	14	103	2	SM00059
Domain	CUB	CUBN CSMD2 SEZ6L	2.65e-03	50	103	3	SM00042
Domain	-	CUBN CSMD2 SEZ6L	2.96e-03	52	103	3	2.60.120.290
Domain	Sushi	CFH CSMD2 SEZ6L	2.96e-03	52	103	3	PF00084
Domain	Kinase-like_dom	ILK NTRK2 CDKL3 SRPK1 PRDM2 CDKL5 FER PAK1 CDK7	3.06e-03	542	103	9	IPR011009
Domain	CUB	CUBN CSMD2 SEZ6L	3.12e-03	53	103	3	PS01180
Domain	WD40	DMXL2 RAE1 WDR88 THOC3 TEP1 DMXL1	3.13e-03	259	103	6	PF00400
Domain	CCP	CFH CSMD2 SEZ6L	3.29e-03	54	103	3	SM00032
Domain	DENN	DENND4A DENND4C	3.44e-03	16	103	2	SM00799
Domain	DENN	DENND4A DENND4C	3.44e-03	16	103	2	PF02141
Domain	dDENN	DENND4A DENND4C	3.44e-03	16	103	2	PF03455
Domain	UDENN	DENND4A DENND4C	3.44e-03	16	103	2	PS50946
Domain	DDENN	DENND4A DENND4C	3.44e-03	16	103	2	PS50947
Domain	dDENN	DENND4A DENND4C	3.44e-03	16	103	2	SM00801
Domain	dDENN_dom	DENND4A DENND4C	3.44e-03	16	103	2	IPR005112
Domain	uDENN_dom	DENND4A DENND4C	3.44e-03	16	103	2	IPR005113
Domain	DENN	DENND4A DENND4C	3.44e-03	16	103	2	PS50211
Domain	DENN_dom	DENND4A DENND4C	3.44e-03	16	103	2	IPR001194
Domain	SUSHI	CFH CSMD2 SEZ6L	3.65e-03	56	103	3	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CSMD2 SEZ6L	3.84e-03	57	103	3	IPR000436
Domain	CUB_dom	CUBN CSMD2 SEZ6L	3.84e-03	57	103	3	IPR000859
Domain	PROTEIN_KINASE_ATP	ILK NTRK2 CDKL3 SRPK1 CDKL5 FER PAK1 CDK7	3.89e-03	459	103	8	PS00107
Domain	Protein_kinase_ATP_BS	NTRK2 CDKL3 SRPK1 CDKL5 FER PAK1 CDK7	5.02e-03	379	103	7	IPR017441
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	CFH MTHFD2 MDM2 TEP1 PTGS2 IGF2R BRCA1 ABCG8 CDK7	2.27e-06	381	104	9	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	CFH MTHFD2 MDM2 TEP1 PTGS2 IGF2R BRCA1 ABCG8 CDK7	2.32e-06	382	104	9	19170196
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	STX8 DMXL2 DENND4A DENND4C DMXL1 LRP8 NBAS IGF2R ADGRL2 VPS13B	2.89e-06	504	104	10	34432599
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	CFH MTHFD2 MDM2 TEP1 PTGS2 IGF2R BRCA1 ABCG8 CDK7	5.11e-06	421	104	9	19692168
Pubmed	Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.	MDM2 BRCA1	8.86e-06	2	104	2	23039163
Pubmed	The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3.	ING3 MDM2	8.86e-06	2	104	2	37279970
Pubmed	Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.	CP HEPH	8.86e-06	2	104	2	30060949
Pubmed	Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.	MDM2 BRCA1	8.86e-06	2	104	2	16563154
Pubmed	Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.	CP HEPH	8.86e-06	2	104	2	22342521
Pubmed	Genetic Variability in the Iron Homeostasis Pathway and Patient Outcomes After Aneurysmal Subarachnoid Hemorrhage.	CP CUBN	8.86e-06	2	104	2	32246437
Pubmed	The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.	CP HEPH	8.86e-06	2	104	2	21051716
Pubmed	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	CP HEPH	8.86e-06	2	104	2	26303407
Pubmed	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	CP HEPH	8.86e-06	2	104	2	29355933
Pubmed	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	CP HEPH	8.86e-06	2	104	2	27991585
Pubmed	The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.	PTGS2 MMP14	8.86e-06	2	104	2	12488433
Pubmed	Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase.	ILK PAK1	8.86e-06	2	104	2	17420447
Pubmed	A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells.	PTGS2 MMP14	8.86e-06	2	104	2	19272160
Pubmed	CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.	NTRK2 CDKL5	8.86e-06	2	104	2	37777961
Pubmed	p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.	PTGS2 PAK1	8.86e-06	2	104	2	27296803
Pubmed	Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.	CP HEPH	8.86e-06	2	104	2	18326691
Pubmed	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	CP HEPH	8.86e-06	2	104	2	25788583
Pubmed	Polymorphisms in Complement Factor H and Hemicentin-1 genes in a Japanese population with dry-type age-related macular degeneration.	CFH HMCN1	8.86e-06	2	104	2	17157600
Pubmed	Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes.	CFH HMCN1	8.86e-06	2	104	2	17591627
Pubmed	Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.	IGF2R BRCA1	8.86e-06	2	104	2	15232000
Pubmed	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	CP HEPH	8.86e-06	2	104	2	15365174
Pubmed	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	CP HEPH	8.86e-06	2	104	2	29883959
Pubmed	Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.	MMP14 CDK7	8.86e-06	2	104	2	27562173
Pubmed	Integrin-linked kinase activity modulates the pro-metastatic behavior of ovarian cancer cells.	ILK MMP14	8.86e-06	2	104	2	26959113
Pubmed	Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.	CP HEPH	8.86e-06	2	104	2	17065470
Pubmed	Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.	CP HEPH	8.86e-06	2	104	2	31263155
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	MTHFD2 MDM2 PTGS2 NOD1 IGF2R BRCA1 MMP14 CDK7	1.10e-05	351	104	8	20453000
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	MDM2 PTGS2 PRDM2 IGF2R BRCA1 ALOXE3	1.27e-05	170	104	6	19064572
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	CFH MTHFD2 MDM2 TEP1 PTGS2 IGF2R BRCA1 CDK7	1.74e-05	374	104	8	19625176
Pubmed	Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.	DENND4A DENND4C	2.65e-05	3	104	2	12906859
Pubmed	EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.	MDM2 PTGS2	2.65e-05	3	104	2	36050601
Pubmed	Deficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments.	LAMP2 CD63	2.65e-05	3	104	2	19474101
Pubmed	Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.	CP HEPH	2.65e-05	3	104	2	23640881
Pubmed	BRCA1 physically associates with p53 and stimulates its transcriptional activity.	MDM2 BRCA1	2.65e-05	3	104	2	9582019
Pubmed	Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations.	MDM2 BRCA1	2.65e-05	3	104	2	19226467
Pubmed	Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line.	MDM2 PTGS2	2.65e-05	3	104	2	15550400
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	CP HEPH	2.65e-05	3	104	2	24988611
Pubmed	Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma.	MDM2 PTGS2	2.65e-05	3	104	2	19346994
Pubmed	Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.	CP HEPH	2.65e-05	3	104	2	18022819
Pubmed	Isolation of dense granules from human platelets.	LAMP2 CD63	2.65e-05	3	104	2	1435334
Pubmed	The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.	ITSN2 PAK1	2.65e-05	3	104	2	11748279
Pubmed	MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.	MDM2 BRCA1	2.65e-05	3	104	2	18026875
Pubmed	Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.	CP HEPH	2.65e-05	3	104	2	30182051
Pubmed	Iron promotes oxidative cell death caused by bisretinoids of retina.	CP HEPH	2.65e-05	3	104	2	29686088
Pubmed	Analysis of variants in the complement factor H, the elongation of very long chain fatty acids-like 4 and the hemicentin 1 genes of age-related macular degeneration in the Finnish population.	CFH HMCN1	2.65e-05	3	104	2	16885922
Pubmed	Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis.	MDM2 PTGS2	2.65e-05	3	104	2	26369479
Pubmed	Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue.	PTGS2 MMP14	2.65e-05	3	104	2	22527932
Pubmed	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.	CP HEPH	2.65e-05	3	104	2	35271829
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	COL4A2 DENND4A MTHFD2 LAMP2 HIBADH ELAC2 DENND4C NBAS IGF2R LMAN2	4.12e-05	686	104	10	28380382
Pubmed	An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection.	IL13RA1 IL17RA	5.29e-05	4	104	2	22245779
Pubmed	Mice with hepcidin-resistant ferroportin accumulate iron in the retina.	CP HEPH	5.29e-05	4	104	2	26506980
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	CP HEPH	5.29e-05	4	104	2	15354085
Pubmed	The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis.	LAMP2 CD63	5.29e-05	4	104	2	19292867
Pubmed	Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation.	CDKL3 CDKL5	5.29e-05	4	104	2	15499549
Pubmed	The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	MDM2 BRCA1	5.29e-05	4	104	2	19707196
Pubmed	Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.	INPP5D LAG3	5.29e-05	4	104	2	18424711
Pubmed	Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.	CP HEPH	5.29e-05	4	104	2	20811044
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	LAMP2 IGF2R CD63 LMAN2	6.28e-05	71	104	4	12754519
Pubmed	A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.	MDM2 PTGS2 IGF2R BRCA1	7.79e-05	75	104	4	20644561
Pubmed	Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.	STX8 SRPK1 BRCA1 CD63 ZNF431	8.55e-05	148	104	5	22898364
Pubmed	Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy.	LAMP2 MDM2	8.80e-05	5	104	2	20540933
Pubmed	Prevention of head and neck cancer: current status and future prospects.	MDM2 PTGS2	8.80e-05	5	104	2	15375804
Pubmed	A protein interaction landscape of breast cancer.	ILK RAE1 MTHFD2 SRPK1 SYNPO MDM2 IGF2R BRCA1 LMAN2	1.24e-04	634	104	9	34591612
Pubmed	Impact of lactobacilli on orally acquired listeriosis.	REG4 CUBN HMCN1 ADGRL2 PRLR	1.31e-04	162	104	5	23012479
Pubmed	Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.	MDM2 BRCA1	1.32e-04	6	104	2	28005077
Pubmed	Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.	MRC1 IGF2R	1.32e-04	6	104	2	32234475
Pubmed	Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.	LRP8 PAK1	1.32e-04	6	104	2	21048135
Pubmed	Exosomal-like vesicles are present in human blood plasma.	LAMP2 CD63	1.32e-04	6	104	2	15908444
Pubmed	Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.	CP HEPH	1.32e-04	6	104	2	28057442
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	NTRK2 TENM2 LRP8 NTNG2	1.65e-04	91	104	4	28558017
Pubmed	MafA transcription factor identifies the early ret-expressing sensory neurons.	NTRK2 KLRG1	1.84e-04	7	104	2	20213756
Pubmed	Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2.	STX8 CD63	1.84e-04	7	104	2	22875976
Pubmed	miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.	INPP5D PAK1	1.84e-04	7	104	2	26121028
Pubmed	Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status.	NTRK2 IGF2R	1.84e-04	7	104	2	20200945
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	STX8 DMXL2 DENND4A DMXL1 IGF2R ITSN2	2.23e-04	285	104	6	34369648
Pubmed	Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.	MRC1 IGF2R PRLR	2.37e-04	40	104	3	36843585
Pubmed	Ferroptosis as a p53-mediated activity during tumour suppression.	MDM2 PTGS2	2.45e-04	8	104	2	25799988
Pubmed	Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.	MDM2 PAK1	2.45e-04	8	104	2	24567357
Pubmed	Genome-wide association study of bipolar disorder in European American and African American individuals.	NTRK2 NCKAP5	2.45e-04	8	104	2	19488044
Pubmed	Affixin activates Rac1 via betaPIX in C2C12 myoblast.	ILK PAK1	2.45e-04	8	104	2	18325335
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CFH COL4A2 B3GALNT2 RNF213 LAMP2 ELAC2 DMXL1 LRP8 IGF2R PTPRF LMAN2 IGSF3	2.53e-04	1201	104	12	35696571
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	STX8 DENND4C LRP8 IGF2R OSBPL3 ITSN2 CD63 SNX9 IGSF3	3.14e-04	719	104	9	35337019
Pubmed	HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.	LAMP2 CD63	3.14e-04	9	104	2	19912576
Pubmed	Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.	CFH HMCN1	3.14e-04	9	104	2	20299368
Pubmed	Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.	NTRK2 LAMP2	3.14e-04	9	104	2	17287360
Pubmed	The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.	MDM2 BRCA1	3.14e-04	9	104	2	8674108
Pubmed	BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.	BRCA1 CDK7	3.14e-04	9	104	2	15282296
Pubmed	Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.	RYR2 IGSF3	3.14e-04	9	104	2	23829686
Pubmed	Brca2 is required for embryonic cellular proliferation in the mouse.	MDM2 BRCA1	3.14e-04	9	104	2	9171369
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	NTRK2 KCNAB2 TENM2 CDKL5 SLCO1C1	3.24e-04	197	104	5	36604605
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	DMXL2 RAE1 MTHFD2 SRPK1 ADAMTS8 MDM2 DMXL1 PAK1 MMP14	3.51e-04	730	104	9	34857952
Pubmed	Circulating AIM prevents hepatocellular carcinoma through complement activation.	CFH CD5L	3.92e-04	10	104	2	25284781
Pubmed	Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice.	ACAT2 IGF2R	3.92e-04	10	104	2	15210844
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM2 ADGRL2	3.92e-04	10	104	2	38713721
Pubmed	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	MDM2 PTGS2 PRDM2 BRCA1	4.32e-04	117	104	4	19124506
Pubmed	Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.	MDM2 PAK1 CDK7	4.33e-04	49	104	3	23397142
Cytoband	Xp21.1	FAM47A FAM47C FAM47B	6.42e-05	34	104	3	Xp21.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	FAM47A FAM47C FAM47B	9.42e-04	84	104	3	chrXp21
Cytoband	1p34	LRP8 PTPRF	2.41e-03	32	104	2	1p34
GeneFamily	WD repeat domain containing	DMXL2 RAE1 WDR88 CFAP43 THOC3 TEP1 DMXL1	9.74e-05	262	74	7	362
GeneFamily	Cyclin dependent kinases	CDKL3 CDKL5 CDK7	1.60e-04	26	74	3	496
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 IL13RA1 LAG3 LAMP2 IGF2R CD63 IL17RA	1.14e-03	394	74	7	471
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CSMD2 SEZ6L	1.64e-03	57	74	3	1179
Coexpression	GSE13306_TREG_VS_TCONV_LAMINA_PROPRIA_DN	NAT8L STAB2 ACAT2 CDKL3 CP SRPK1 NOD1 OSBPL3	1.38e-06	200	104	8	M3222
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HMGL	MRC1 IL13RA1 DENND4A INPP5D RNF213 GPR183 PTGS2 RYR2 CD5L ITSN2 IL17RA CDK7	3.17e-06	577	104	12	M39051
Coexpression	BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	NAT8L DMXL2 FAHD2B NTRK2 EMID1 ADAMTS8 TENM2 PRDM2 SLCO1C1 TM4SF4 ALOXE3 LMAN2 IL17RA PRLR	1.86e-05	930	104	14	MM893
Coexpression	GSE6092_CTRL_VS_BORRELIA_BIRGDOFERI_INF_ENDOTHELIAL_CELL_DN	ING3 CHD2 GPR183 CUBN GK5 SCN3A	2.93e-05	149	104	6	M6708
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_500	DENND4A RYR2 NBAS HMCN1	4.43e-05	41	102	4	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_500
CoexpressionAtlas	Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4	CFH COL4A2 MRC1 IL13RA1 STAB2 CP PTGS2 HMCN1 CD63 MMP14	5.04e-05	439	102	10	GSM777059_500
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4	CFH MRC1 IL13RA1 DMXL2 CP PTGS2 PAK1 CD63 MMP14	7.10e-05	368	102	9	GSM854258_500
CoexpressionAtlas	Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5	CFH COL4A2 IL13RA1 CP PTGS2 PTPRF HMCN1 CD63 ADGRL2 MMP14	8.27e-05	466	102	10	GSM777050_500
CoexpressionAtlas	Myeloid Cells, DC.11cloSer.SI, CD45+ MHCII+ CD11c-lo CD11b+, Small Intestine, avg-5	CFH MRC1 IL13RA1 DMXL2 CP LAMP2 PTGS2 CD63 MMP14	8.54e-05	377	102	9	GSM854280_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_200	RNF213 GK5 RYR2 ZFPM2 HMCN1 ADGRL2	9.32e-05	152	102	6	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_200
CoexpressionAtlas	Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3	CFH CP PTGS2 CD63 MMP14	1.05e-04	97	102	5	GSM777043_100
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3	CFH MRC1 IL13RA1 STAB2 LAMP2 PTGS2 PAK1 ADGRL2 MMP14	1.64e-04	411	102	9	GSM538239_500
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_500	COL4A2 MRC1 DENND4A STAB2 INPP5D GPR183 HMCN1 ARHGAP31 ITSN2	1.76e-04	415	102	9	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_500
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_top-relative-expression-ranked_500	COL4A2 MRC1 INPP5D GPR183 NOD1 HMCN1 ARHGAP31 ITSN2 ADGRL2	1.79e-04	416	102	9	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_1000	CFH DENND4A RNF213 LAMP2 GK5 DENND4C RYR2 ZFPM2 PTPRF HMCN1 ADGRL2 MMP14	2.25e-04	740	102	12	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_1000
ToppCell	AT1-AT2_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 NCKAP5 SYNPO ERVW-1 PTGS2 ARNT2 ALOXE3	1.85e-07	175	104	7	9a95ab5c361ebaa8747983c5a0d69025682a19ad
ToppCell	IPF-Myeloid-Mast\|IPF / Disease state, Lineage and Cell class	DENND4A EMID1 LGALS12 PTGS2 NBAS FER PAK1	2.59e-07	184	104	7	c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCell	ASK452-Immune-Mast_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	DENND4A EMID1 PTGS2 FER PAK1 CD63 KLRG1	3.00e-07	188	104	7	840215e16cff90f821f776186284eafcf2350690
ToppCell	facs-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.11e-07	189	104	7	bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.11e-07	189	104	7	40cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.11e-07	189	104	7	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.22e-07	190	104	7	0b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.34e-07	191	104	7	8a73d2df079566fca4cbb5cdb85721c2e87134c8
ToppCell	(1)_Control_(PBS)\|World / Stress and Cell class	CFH MRC1 STAB2 LAMP2 ARHGAP31 MMP14 IGSF3	3.34e-07	191	104	7	b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCell	droplet-Lung-21m-Mesenchymal\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63 MMP14	3.34e-07	191	104	7	10a9db1caa0fdb51ace8537f42b2c66f7c97e0f5
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	COL4A2 MRC1 STAB2 DENND4C NOD1 ARHGAP31 ADGRL2	3.98e-07	196	104	7	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	COL4A2 NTRK2 HEPH RYR2 SLCO1C1 SCN3A PRLR	4.26e-07	198	104	7	0f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH COL4A2 EMID1 CP CD63 ADGRL2 MMP14	4.40e-07	199	104	7	6139687a3a5025cb98da4dba0183f95fcae3dc61
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 INPP5D KCNAB2 LRP8 CD5L IL17RA	2.02e-06	159	104	6	0c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 DMXL2 CUBN GK5 ATP10A CD5L	2.25e-06	162	104	6	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	Control-Myeloid-Mast\|Control / Disease state, Lineage and Cell class	DENND4A EMID1 LGALS12 PTGS2 FER PAK1	2.98e-06	170	104	6	9a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCell	Control-Myeloid-Mast\|World / Disease state, Lineage and Cell class	DENND4A EMID1 LGALS12 PTGS2 FER PAK1	3.08e-06	171	104	6	ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	MRC1 STAB2 CP SCN3A CD63 MMP14	3.18e-06	172	104	6	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 NCKAP5 SYNPO ERVW-1 PTGS2 CDKL5	3.52e-06	175	104	6	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MTHFD2 NTRK2 ADAMTS8 ATP10A RYR2 SCN3A	3.52e-06	175	104	6	316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MTHFD2 NTRK2 ADAMTS8 ATP10A RYR2 SCN3A	3.52e-06	175	104	6	a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 STAB2 EMID1 CP CD63 MMP14	3.52e-06	175	104	6	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 STAB2 EMID1 CP CD63 MMP14	3.52e-06	175	104	6	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 STAB2 EMID1 CP CD63 MMP14	3.63e-06	176	104	6	057d2759fdc67176c25802b57a78064d8cc93205
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 STAB2 EMID1 CP CD63 MMP14	3.63e-06	176	104	6	b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCell	P28-Endothelial-lymphatic_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 STAB2 EMID1 CP CD63 MMP14	3.75e-06	177	104	6	6e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCell	P28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 STAB2 EMID1 CP CD63 MMP14	3.75e-06	177	104	6	e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 IGSF3	4.27e-06	181	104	6	b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 IGSF3	4.27e-06	181	104	6	cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 IGSF3	4.27e-06	181	104	6	ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 MMP14	4.41e-06	182	104	6	2cc434e46985c66fc36de05344a67aa96d90abc9
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 MMP14	4.41e-06	182	104	6	0cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	DENND4A LGALS12 PTGS2 NBAS FER PAK1	4.41e-06	182	104	6	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	facs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CD63 MMP14	4.41e-06	182	104	6	3e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NAT8L NTRK2 CA10 HIBADH OSBPL3 ARNT2	4.41e-06	182	104	6	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	mild-Myeloid-mDC\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MRC1 IL13RA1 GPR183 ARHGAP31 PAK1 SEZ6L	4.69e-06	184	104	6	8b37c00d59d9992d3b43268991da7bb94646c70e
ToppCell	LPS_only\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND4A MTHFD2 RNF213 CHD2 PTGS2 VPS13B	4.84e-06	185	104	6	a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH SYNPO CA10 ATP10A TENM2 ZFPM2	4.84e-06	185	104	6	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ADGRL2 SNX9	5.15e-06	187	104	6	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ADGRL2 SNX9	5.15e-06	187	104	6	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	CFH TENM2 RYR2 ZFPM2 HMCN1 ADGRL2	5.15e-06	187	104	6	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ARNT2 IGSF3	5.31e-06	188	104	6	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	CA10 HMCN1 OSBPL3 SCN3A ARNT2 ADGRL2	5.31e-06	188	104	6	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ARNT2 IGSF3	5.31e-06	188	104	6	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	INPP5D NTRK2 GPR183 CA10 ATP10A OSBPL3	5.47e-06	189	104	6	78dcda09109a5cfb04ba069f16ec80987b3ad432
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ARNT2 ADGRL2	5.47e-06	189	104	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	CFH CP PAK1 CD63 MMP14 IGSF3	5.47e-06	189	104	6	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ARNT2 ADGRL2	5.47e-06	189	104	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CA10 HMCN1 OSBPL3 SCN3A ADGRL2 SNX9	5.47e-06	189	104	6	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CFH INPP5D CP SYNPO PTGS2 ARHGAP31	5.64e-06	190	104	6	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CDKL5 CD63	5.64e-06	190	104	6	f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CDKL5 CD63	5.64e-06	190	104	6	a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCell	droplet-Lung-21m-Endothelial-lymphatic_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 STAB2 EMID1 CP CDKL5 CD63	5.64e-06	190	104	6	57c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	36467322096bc766cd777dae3bfb4e65511e492c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	a261f0738d974784bbdd60f23092bfbcca464459
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 STAB2 EMID1 CP SCN3A SEZ6L	5.81e-06	191	104	6	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	94795daf05061baa3b72a1b01c9e940af86de044
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	6594398cc8151c73696391a43ac110c10283dab1
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	d4f535b06ad483448ab692e9900c872c78cbed60
ToppCell	facs-Aorta-Heart-18m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NTRK2 CP CD63 MMP14 IGSF3	5.81e-06	191	104	6	6242f83acaf1714e9c1771a832cb67674b19e96d
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	5c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 EMID1 CP ZFPM2 SCN3A IGSF3	5.81e-06	191	104	6	51cff0594ac7ad8c065c8ea2301f8c149bd062b4
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	de3e9b704621b26836c2ddc39fa3e840dfb4541b
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.81e-06	191	104	6	b5210de890d338602857b5907135705a507bc2b0
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 EMID1 CP ZFPM2 SCN3A IGSF3	5.81e-06	191	104	6	a55b6f0a7ec1a8852ffca593cfdccd7edea09b7b
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 EMID1 CP ZFPM2 SCN3A IGSF3	5.81e-06	191	104	6	38681a1b182d6af5cce85db5431b6eba4b20ad96
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 STAB2 EMID1 CP SCN3A SEZ6L	5.81e-06	191	104	6	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	facs-Aorta-Heart-18m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NTRK2 CP CD63 MMP14 IGSF3	5.99e-06	192	104	6	6d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.99e-06	192	104	6	d22c1135867bcb9076435e2c6eb1cc1248990d0c
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTRK2 DENND4C PTPRF TM4SF4 PRLR SEZ6L	5.99e-06	192	104	6	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NTRK2 CP CD63 MMP14 IGSF3	5.99e-06	192	104	6	2c6406bc97c3224099b94a43f2890f057b528fa6
ToppCell	droplet-Lung-nan-18m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NAT8L CP ADAMTS8 SCN3A CD63	5.99e-06	192	104	6	c09966f4d63a739a56db4df7e0e0ee9ecacd21ad
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH CP ADAMTS8 CD63 MMP14 IGSF3	5.99e-06	192	104	6	1b228f0929b505de82a39bf64c837887b0e56701
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 IL13RA1 NCKAP5 GPR183 PAK1 SEZ6L	5.99e-06	192	104	6	dfb9101622f7d2f2c392e850cff07becfc8c655e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 IL13RA1 NCKAP5 GPR183 PAK1 SEZ6L	5.99e-06	192	104	6	d39133cf1a20af6f2970188630fc3b27a4cfc9c5
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NTRK2 CP CD63 MMP14 IGSF3	5.99e-06	192	104	6	47aed7c8e6f5ce1084821212a04f568319e65fd6
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH NAT8L CP ADAMTS8 CD63 MMP14	5.99e-06	192	104	6	5876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH CP ADAMTS8 CD63 MMP14 IGSF3	6.17e-06	193	104	6	fe9720185929ef849edd1b8eb4854306b392e5a2
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CP ADAMTS8 SCN3A CD63 MMP14	6.17e-06	193	104	6	abdfb8b1dbdcb424042e21017a9e829fced4457e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 IL13RA1 NCKAP5 ARHGAP31 PAK1 SEZ6L	6.35e-06	194	104	6	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	CFH CSMD2 RYR2 ZFPM2 HMCN1 MMP14	6.35e-06	194	104	6	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 IL13RA1 NCKAP5 ARHGAP31 PAK1 SEZ6L	6.35e-06	194	104	6	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A2 NCKAP5 ZFPM2 HMCN1 ARHGAP31 ADGRL2	6.35e-06	194	104	6	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	MRC1 STAB2 ATP10A HMCN1 SCN3A IGSF3	6.54e-06	195	104	6	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTRK2 EMID1 TENM2 DENND4C PRLR SEZ6L	6.54e-06	195	104	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 IL13RA1 NCKAP5 GPR183 PAK1 SEZ6L	6.54e-06	195	104	6	4cbc36fb3ef9aef61367d3b37070a9a85fae1418
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	CFH INPP5D SYNPO ADAMTS8 HEPH MMP14	6.54e-06	195	104	6	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL4A2 CP HMCN1 CD63 MMP14	6.74e-06	196	104	6	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MRC1 LAG3 GPR183 CD5L CD63 MMP14	6.74e-06	196	104	6	e0447ad2efb021b63c7fef000d39b6b21fbe6113
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH COL4A2 CP HMCN1 CD63 MMP14	6.74e-06	196	104	6	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH CP SYNPO IGF2R SLCO1C1 HMCN1	6.74e-06	196	104	6	7d5eaed189aa6116f3799be010139fb675ec65e0
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	MRC1 LAG3 GPR183 CD5L CD63 MMP14	6.74e-06	196	104	6	3bca88eede3dd7368715ced02e3bacd1e3e82cab
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MRC1 DMXL2 INPP5D KCNAB2 RNF213 IL17RA	6.94e-06	197	104	6	e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH NTRK2 EMID1 NCKAP5 TENM2 MMP14	6.94e-06	197	104	6	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH NTRK2 EMID1 NCKAP5 TENM2 MMP14	6.94e-06	197	104	6	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CFH NTRK2 EMID1 NCKAP5 TENM2 MMP14	6.94e-06	197	104	6	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	CFH COL4A2 CSMD2 RYR2 ZFPM2 HMCN1	6.94e-06	197	104	6	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 IL13RA1 NCKAP5 GPR183 PAK1 SEZ6L	7.14e-06	198	104	6	d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRC1 IL13RA1 NCKAP5 GPR183 PAK1 SEZ6L	7.14e-06	198	104	6	08ad0bece508bb4f9cc126d94839b5c89ce21ba8
Computational	Genes in the cancer module 470.	PTGS2 ADGRL2 PRLR	1.22e-04	16	67	3	MODULE_470
Drug	2'-aminobiphenyl-2,3-diol	STX8 CA10 ALOXE3	1.78e-06	6	103	3	CID000441379
Drug	Clioquinol [130-26-7]; Up 200; 13uM; PC3; HT_HG-U133A	LAG3 ADAMTS8 CFAP43 PTGS2 PRDM2 SLCO1C1 ALOXE3 KLRG1	2.45e-06	190	103	8	4663_UP
Disease	severe acute respiratory syndrome, COVID-19	COL4A2 INPP5D NTRK2 KCNAB2 LGALS12 TENM2 ZFPM2 ARNT2 FER	2.18e-05	447	100	9	EFO_0000694, MONDO_0100096
Disease	DnaJ homolog subfamily B member 12 measurement	CFH CHRNB3	3.40e-05	3	100	2	EFO_0802487
Disease	low-density lipoprotein receptor-related protein 8 measurement	CFH LRP8	3.40e-05	3	100	2	EFO_0020538
Disease	Malignant neoplasm of prostate	STAB2 ADAMTS8 MDM2 PTGS2 ELAC2 IGF2R BRCA1 ITSN2 INTS4 ALOXE3	4.69e-05	616	100	10	C0376358
Disease	Prostatic Neoplasms	STAB2 ADAMTS8 MDM2 PTGS2 ELAC2 IGF2R BRCA1 ITSN2 INTS4 ALOXE3	4.69e-05	616	100	10	C0033578
Disease	polyp of gallbladder	TM4SF4 ABCG8	6.79e-05	4	100	2	MONDO_0021416
Disease	semaphorin-6A measurement	CFH MRC1	6.79e-05	4	100	2	EFO_0020721
Disease	NAD-dependent protein deacylase sirtuin-5, mitochondrial measurement	CFH ZFPM2	6.79e-05	4	100	2	EFO_0801822
Disease	galectin-7 measurement	CFH ZFPM2	1.69e-04	6	100	2	EFO_0022034
Disease	somatostatin-28 measurement	CFH ZFPM2	1.69e-04	6	100	2	EFO_0020745
Disease	Epilepsy, Cryptogenic	ILK KCNAB2 CHD2 CDKL5	1.77e-04	82	100	4	C0086237
Disease	Awakening Epilepsy	ILK KCNAB2 CHD2 CDKL5	1.77e-04	82	100	4	C0751111
Disease	Aura	ILK KCNAB2 CHD2 CDKL5	1.77e-04	82	100	4	C0236018
Disease	primary dental caries	CFH CUBN OSBPL3	2.09e-04	34	100	3	EFO_0600095
Disease	Glioma	NTRK2 MDM2 PTGS2 DMXL1	2.23e-04	87	100	4	C0017638
Disease	Mental Depression	NTRK2 CSMD2 PTGS2 CHRNB3 SLCO1C1 BRCA1	2.33e-04	254	100	6	C0011570
Disease	cholelithiasis	TM4SF4 SNX9 ABCG8 VPS13B	2.33e-04	88	100	4	EFO_0004799
Disease	pleckstrin homology domain-containing family A member 1 measurement	CFH ZFPM2	2.36e-04	7	100	2	EFO_0802873
Disease	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 measurement	CFH SYNPO	2.36e-04	7	100	2	EFO_0802332
Disease	coronary artery disease (is_implicated_in)	ACAT2 CUBN LRP8 ARHGAP31	3.79e-04	100	100	4	DOID:3393 (is_implicated_in)
Disease	synaptotagmin-11 measurement	CFH ZFPM2	4.03e-04	9	100	2	EFO_0802108
Disease	brain ischemia (biomarker_via_orthology)	CP PTGS2 PAK1 MMP14	4.09e-04	102	100	4	DOID:2316 (biomarker_via_orthology)
Disease	Depressive disorder	NTRK2 CSMD2 PTGS2 CHRNB3 SLCO1C1 BRCA1	4.62e-04	289	100	6	C0011581
Disease	Aortic Aneurysm, Abdominal	PTGS2 MMP14	5.03e-04	10	100	2	C0162871
Disease	Malignant mesothelioma	ILK HEPH RYR2 PTPRF	5.26e-04	109	100	4	C0345967
Disease	Epilepsy	ILK KCNAB2 CHD2 CDKL5	5.26e-04	109	100	4	C0014544
Disease	UDP-glucuronic acid decarboxylase 1 measurement	CFH ZFPM2	6.13e-04	11	100	2	EFO_0803221
Disease	Cognitive impairment	RYR2 DMXL1	6.13e-04	11	100	2	HP_0100543
Disease	coronary artery disease	COL4A2 INPP5D RNF213 CHD2 NT5C1B ZFPM2 DMXL1 IGF2R FER ADGRL2 ABCG8 SEZ6L	7.20e-04	1194	100	12	EFO_0001645
Disease	vascular endothelial growth factor A measurement	CFH ZFPM2	7.34e-04	12	100	2	EFO_0010804
Disease	Mouth Diseases	PTGS2 BRCA1	7.34e-04	12	100	2	C0026636
Disease	sugar consumption measurement	COL4A2 NBAS PTPRF VPS13B	7.55e-04	120	100	4	EFO_0010158
Disease	uric acid measurement	STX8 REG4 CHD2 CUBN TENM2 TM4SF4 LMAN2 ADGRL2	1.12e-03	610	100	8	EFO_0004761
Disease	testosterone measurement	COL4A2 STX8 DENND4A EMID1 ZFPM2 NTNG2 PTPRF HMCN1 ANAPC1 LMAN2 ADGRL2 PRLR	1.27e-03	1275	100	12	EFO_0004908
Disease	Liver Cirrhosis, Experimental	COL4A2 ILK INPP5D PTGS2 IGF2R CD5L CD63 ABCG8 PRLR	1.28e-03	774	100	9	C0023893
Disease	transitional cell carcinoma (is_marker_for)	PTGS2 PAK1 MMP14	1.29e-03	63	100	3	DOID:2671 (is_marker_for)
Disease	sarcoidosis (is_implicated_in)	CFH PTGS2	1.32e-03	16	100	2	DOID:11335 (is_implicated_in)
Disease	C-X-C motif chemokine 6 measurement	CFH ZFPM2	1.32e-03	16	100	2	EFO_0008059
Disease	breast carcinoma (is_marker_for)	IGF2R BRCA1 MMP14	1.48e-03	66	100	3	DOID:3459 (is_marker_for)
Disease	major depressive disorder (is_marker_for)	NTRK2 CHRNB3	1.50e-03	17	100	2	DOID:1470 (is_marker_for)
Disease	glycochenodeoxycholate measurement	ANKRD13D NTNG2	1.50e-03	17	100	2	EFO_0010490
Disease	Grand Mal Status Epilepticus	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0311335
Disease	Petit mal status	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0270823
Disease	Complex Partial Status Epilepticus	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0393734
Disease	Status Epilepticus, Subclinical	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0751522
Disease	Simple Partial Status Epilepticus	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0751524
Disease	Non-Convulsive Status Epilepticus	NTRK2 LAMP2 PTGS2	1.55e-03	67	100	3	C0751523
Disease	melanoma	CP CUBN MDM2 PTGS2 PAK1	1.59e-03	248	100	5	C0025202
Disease	Status Epilepticus	NTRK2 LAMP2 PTGS2	1.61e-03	68	100	3	C0038220
Disease	progression free survival, ovarian carcinoma	NTRK2 NBAS	1.68e-03	18	100	2	EFO_0001075, EFO_0004920
Disease	Age-related macular degeneration	CFH HMCN1	1.68e-03	18	100	2	cv:C0242383
Disease	Prostate cancer, familial	ELAC2 BRCA1 MMP14	1.68e-03	69	100	3	C2931456
Disease	Malignant Glioma	NTRK2 PTGS2 DMXL1	1.75e-03	70	100	3	C0555198
Disease	mixed gliomas	NTRK2 PTGS2 DMXL1	1.75e-03	70	100	3	C0259783
Disease	Cholecystitis	TM4SF4 ABCG8	1.87e-03	19	100	2	HP_0001082
Disease	bipolar disorder (is_marker_for)	NTRK2 PTGS2	1.87e-03	19	100	2	DOID:3312 (is_marker_for)
Disease	Autistic Disorder	NTRK2 CP ATP10A PTGS2 PRLR	1.98e-03	261	100	5	C0004352
Disease	corneal hysteresis	ADAMTS8 ANAPC1	2.08e-03	20	100	2	EFO_0010066
Disease	glaucoma (is_marker_for)	CFH HEPH	2.08e-03	20	100	2	DOID:1686 (is_marker_for)
Disease	amino acid measurement	REG4 SYNPO CA10 HIBADH RYR2 NBAS PAK1 ADGRL2	2.17e-03	678	100	8	EFO_0005134
Disease	Congenital diaphragmatic hernia	ZFPM2 IGF2R	2.29e-03	21	100	2	C0235833
Disease	cardiovascular system disease (is_implicated_in)	CFH PTGS2	2.29e-03	21	100	2	DOID:1287 (is_implicated_in)
Disease	Lewy Body Disease	NTRK2 IGF2R	2.51e-03	22	100	2	C0752347
Disease	lymphocyte count, response to vaccine	NBAS OSBPL3	2.51e-03	22	100	2	EFO_0004587, EFO_0004645
Disease	Immunologic Deficiency Syndromes	CFH NBAS	2.75e-03	23	100	2	C0021051
Disease	idiopathic pulmonary fibrosis (is_marker_for)	NTRK2 PTGS2	2.75e-03	23	100	2	DOID:0050156 (is_marker_for)
Disease	beverage consumption measurement	NTRK2 RYR2 ITSN2	2.85e-03	83	100	3	EFO_0010088
Disease	West Syndrome	NTRK2 CDKL5	2.99e-03	24	100	2	C0037769
Disease	nephrotic syndrome (implicated_via_orthology)	PTGS2 ITSN2	2.99e-03	24	100	2	DOID:1184 (implicated_via_orthology)
Disease	Albuminuria	CP PTGS2	2.99e-03	24	100	2	C0001925
Disease	response to peginterferon alfa-2a	ATP10A NBAS	3.24e-03	25	100	2	EFO_0010103
Disease	pallidum volume	CHRNB3 FER	3.24e-03	25	100	2	EFO_0006933
Disease	breast cancer (implicated_via_orthology)	BRCA1 CDK7	3.24e-03	25	100	2	DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRSFYEKNPSCSRPW	NT5C1B	286	Q96P26
VVWTPPASYKSSCTM	CHRNB3	141	Q05901
PTMHCWTPTSDLYIG	CFAP43	256	Q8NDM7
SWVPLVSKMCPSDVY	ANKRD13D	131	Q6ZTN6
GNYPSNMDCSWKIAL	CSMD2	1986	Q7Z408
QTLPWSPCSAMYLTE	ADAMTS8	401	Q9UP79
TSYGKPVDIWALGCM	CDKL3	176	Q8IVW4
EPMCPVGMNKLWSGY	COL4A2	1501	P08572
EQLAQFKMPWTSPSC	ABCG8	66	Q9H221
SYLCMISTGTWNPKG	ADGRL2	501	O95490
YGRKPIWLSQMSCSG	CD5L	196	O43866
NETTCYMGKWSSPPQ	CFH	911	P08603
YMGKWSSPPQCEGLP	CFH	916	P08603
NPKPYMSWQCHSKAT	DMXL2	2841	Q8TDJ6
CPVTGSMPKPYLTWQ	DMXL1	2821	Q9Y485
SMPKPYLTWQCHNKT	DMXL1	2826	Q9Y485
SCATCYPPSNPYWTM	ATP10A	1251	O60312
HCTGYIKAWPPAGMT	ARNT2	281	Q9HBZ2
GYPKSALRDWMGCPS	MMP14	496	P50281
PMGATIECWPSNSKY	DENND4A	236	Q7Z401
IKAPNYSCVMTGSWD	RAE1	136	P78406
GWFPCNYVEKMPSSE	ITSN2	806	Q9NZM3
AYNSSARIPKCPWME	INTS4	916	Q96HW7
QWVSSCLKGEGMPPY	ANAPC1	846	Q9H1A4
QPGLTMCKGDSVVWY	CP	631	P00450
CGAANYTDWEKIPSM	CD63	146	P08962
SSPGMDSTPWYCDKP	FAM47C	11	Q5HY64
VCMTWRLAGPGSEKY	IL17RA	341	Q96F46
IKPYQGVGSSSMPLW	LMAN2	61	Q12907
WKIYAPGFPCMVDVN	ALOXE3	146	Q9BYJ1
CSSRWQQMAKSPEFP	ZFPM2	571	Q8WW38
APKGKWYCPQCTAAM	ING3	396	Q9NXR8
GTRIYSWSCPTVMSP	LGALS12	11	Q96DT0
RSQGMDSKPWYCDKP	FAM47B	11	Q8NA70
EWMPPAGAATTSCYP	NOD1	546	Q9Y239
MGNVICSPAYWKPST	PTGS2	521	P35354
WDAPLGSSYMCNKEQ	LAMP2	321	P13473
VSPMDSGPWGCILTY	LAG3	231	P18627
ELMATGYPKSWDVCS	NBAS	1306	A2RRP1
YMKCSWLPGRNTSPD	IL13RA1	141	P78552
MTWSPLACGIVSGKY	KCNAB2	241	Q13303
IMCSATGYPKPKIAW	HMCN1	631	Q96RW7
PEQSKRSTMVGTPYW	PAK1	416	Q13153
SSPSKCPSLDDRWYM	BRCA1	1496	P38398
PKYSCVCDAGWMFSP	CUBN	241	O60494
YSCHVEEWLPSPSGM	IGSF3	916	O75054
SCPSCPDRWMKYGNH	KLRG1	71	Q96E93
PVTWPDKVVCVGMNY	FAHD2B	101	Q6P2I3
APSNEPEYLCKWMGL	CHD2	406	O14647
WETFSLGVCPYPGMT	FER	751	P16591
QWPDMCSLPDYVTFK	CDK7	236	P50613
CETGMLSSPQYSPWE	B3GALNT2	466	Q8NCR0
KFSFQCPGRMYAPAW	ILK	341	Q13418
WPKMVTESCYFPAQR	REXO1L1P	166	Q8IX06
PMGATIECWDPETKY	DENND4C	236	Q5VZ89
RSPGMDSKPWYCNKR	FAM47A	11	Q5JRC9
NASTTGLFDPYKMCW	GK5	216	Q6ZS86
VKTAGLCSTGEMWYP	GCNA	551	Q96QF7
NCPWPMSCPGSSYRT	EMID1	61	Q96A84
DGSMTIPPCYETASW	CA10	236	Q9NS85
IPPCYETASWIIMNK	CA10	241	Q9NS85
APYGKSVDMWSVGCI	CDKL5	186	O76039
SCQMLVSKGYPDIGW	RYR2	2276	Q92736
KYTCACPDTMWLGPD	LRP8	716	Q14114
SPPCFDEYKMSKEWT	PRDM2	796	Q13029
SACVWRANPMPKGYE	OSBPL3	766	Q9H4L5
LTCVAVGAPMPYVKW	PTPRF	251	P10586
MRPSCAPGWFYHKSN	REG4	26	Q9BYZ8
EYCGELKGDPTMSWN	MRC1	751	P22897
GPTWEFYACQPKVMR	NTNG2	31	Q96CW9
YTFAWPTATACPMKS	IGF2R	1496	P11717
PMWVYPTSTFDCVVA	SNX9	241	Q9Y5X1
YWTGKMINPSCPGGL	ERVW-1	86	Q9UQF0
LSWSSDPPFCEKIMY	SEZ6L	791	Q9BYH1
WEKCPLTMNSSGFDP	SLC6A16	221	Q9GZN6
EPPSVITKWGYKDCM	NCKAP5	416	O14513
CLDQYSMLPATPWGV	MTHFD2	166	P13995
RCPSPTMSLPSSWKY	SYNPO	751	Q8N3V7
CMEYPNFEETKSLPW	GPR183	181	P32249
GPTAQDPACLTWMYF	HEPH	526	Q9BQS7
DYWKCTSCNEMNPPL	MDM2	301	Q00987
ATGMKYNLPSWCDRV	INPP5D	661	Q92835
YLPDTGLCSCDPNWM	TENM2	716	Q9NT68
LNSCWATPSADFMYP	TECTB	201	Q96PL2
NCVFMTLSNPPDWTK	SCN3A	141	Q9NY46
SGYNTPADIWSTACM	SRPK1	526	Q96SB4
CWSSDTYNPVPGVMD	HIBADH	251	P31937
LSCSVAGDPVPNMYW	NTRK2	216	Q16620
TWIAMAYCSPKQGVS	RNF213	1636	Q63HN8
PAMCSYFTKDLWPEQ	ZNF431	106	Q8TF32
SEYCPGKLSWGTMAR	WDR88	26	Q6ZMY6
PYCWKGMTPEQQAAI	RIBC1	271	Q8N443
TSGWKVVYSGDTMPC	ELAC2	656	Q9BQ52
CMKPGDAPSEIWSSY	TEP1	2396	Q99973
GAGIPYSVPAWSCQM	ACAT2	76	Q9BWD1
KWEPMCGENGITYVS	SLCO1C1	486	Q9NYB5
MAPWCSVSSGPSRYV	THOC3	21	Q96J01
TWDPQCISMEGKIPY	PRLR	391	P16471
GPRPNKSEMWDVFCY	STAB2	2276	Q8WWQ8
EPGDPKVTWMTSSYC	ARHGAP31	1136	Q2M1Z3
MAPDPWFSTYDSTCQ	STX8	1	Q9UNK0
GEQPAMKSSSLPCWD	VPS13B	3151	Q7Z7G8
KGPKCLMANSTWGYP	TM4SF4	116	P48230
MWLSTSPYRKGSQCG	ZNF861P	1	O60384
TPYEFHEWPMGCKQS	ZNF285	286	Q96NJ3
PMLTSACPGWVRYAE	NARF	166	Q9UHQ1
YMKPPGSCFWVAVLD	NAT8L	176	Q8N9F0