Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metallopeptidase activity	XPNPEP1 FOLH1 TLL1 TLL2	4.98e-04	200	37	4	GO:0008237
GeneOntologyMolecularFunction	oligopeptide binding	FOLH1 GSTA5	6.22e-04	20	37	2	GO:1900750
GeneOntologyMolecularFunction	lipid kinase activity	DGKH SPHK1	2.62e-03	41	37	2	GO:0001727
GeneOntologyMolecularFunction	protein phosphatase 2A binding	ANKLE2 SPHK1	2.75e-03	42	37	2	GO:0051721
GeneOntologyMolecularFunction	growth factor activity	BMP8B BMP8A GDF6	4.00e-03	173	37	3	GO:0008083
MousePheno	epididymis epithelium degeneration	BMP8B BMP8A	1.62e-05	3	33	2	MP:0004934
MousePheno	abnormal atrioventricular valve morphology	XPNPEP1 ARSB DNAH5 TLL1	2.00e-05	69	33	4	MP:0002745
MousePheno	abnormal heart atrium and ventricle connection	XPNPEP1 ARSB DNAH5 TLL1	2.78e-05	75	33	4	MP:0010435
MousePheno	increased male germ cell apoptosis	XKR8 BMP8B BMP8A CHTF18 CRY1	7.48e-05	189	33	5	MP:0014052
MousePheno	epididymis degeneration	BMP8B BMP8A	1.13e-04	7	33	2	MP:0004935
MousePheno	abnormal mitral valve morphology	XPNPEP1 ARSB TLL1	1.20e-04	41	33	3	MP:0000286
MousePheno	abnormal male germ cell apoptosis	XKR8 BMP8B BMP8A CHTF18 CRY1	2.12e-04	236	33	5	MP:0008280
MousePheno	abnormal male germ cell physiology	XKR8 BMP8B BMP8A CHTF18 CRY1	2.48e-04	244	33	5	MP:0020362
MousePheno	abnormal germ cell physiology	XKR8 BMP8B BMP8A CHTF18 CRY1	3.75e-04	267	33	5	MP:0020363
MousePheno	increased apoptosis	LRP2 XKR8 SRRT BMP8B NR2E3 HAX1 BMP8A CHTF18 CRY1	4.04e-04	1008	33	9	MP:0006042
MousePheno	increased cell death	LRP2 XKR8 SRRT BMP8B NR2E3 HAX1 BMP8A CHTF18 CRY1	4.37e-04	1019	33	9	MP:0012556
MousePheno	abnormal articular cartilage morphology	ARSB GDF6	4.83e-04	14	33	2	MP:0006433
MousePheno	abnormal heart valve morphology	XPNPEP1 ARSB DNAH5 TLL1	5.60e-04	163	33	4	MP:0000285
Domain	BMP_1/tolloid-like	TLL1 TLL2	1.21e-05	3	38	2	IPR015446
Domain	TGFb_propeptide	BMP8B BMP8A GDF6	2.46e-05	28	38	3	PF00688
Domain	TGF-b_N	BMP8B BMP8A GDF6	2.46e-05	28	38	3	IPR001111
Domain	EGF_CA	LRP2 TLL1 TLL2 GAS6	2.74e-05	86	38	4	PF07645
Domain	TGF-beta-rel	BMP8B BMP8A GDF6	3.70e-05	32	38	3	IPR015615
Domain	TGFb_CS	BMP8B BMP8A GDF6	3.70e-05	32	38	3	IPR017948
Domain	EGF_Ca-bd_CS	LRP2 TLL1 TLL2 GAS6	4.41e-05	97	38	4	IPR018097
Domain	EGF_CA	LRP2 TLL1 TLL2 GAS6	4.77e-05	99	38	4	PS01187
Domain	TGFB	BMP8B BMP8A GDF6	5.76e-05	37	38	3	SM00204
Domain	TGF_BETA_2	BMP8B BMP8A GDF6	5.76e-05	37	38	3	PS51362
Domain	TGF_beta	BMP8B BMP8A GDF6	5.76e-05	37	38	3	PF00019
Domain	TGF-b_C	BMP8B BMP8A GDF6	5.76e-05	37	38	3	IPR001839
Domain	TGF_BETA_1	BMP8B BMP8A GDF6	5.76e-05	37	38	3	PS00250
Domain	Peptidase_M12A	TLL1 TLL2	6.02e-05	6	38	2	IPR001506
Domain	Astacin	TLL1 TLL2	6.02e-05	6	38	2	PF01400
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 TLL1 TLL2 GAS6	6.24e-05	106	38	4	IPR000152
Domain	EGF_CA	LRP2 TLL1 TLL2 GAS6	1.08e-04	122	38	4	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 TLL1 TLL2 GAS6	1.15e-04	124	38	4	IPR001881
Domain	EGF	LRP2 TLL1 TLL2 GAS6	1.22e-04	126	38	4	PF00008
Domain	Inhibin_asu	BMP8B BMP8A	3.10e-04	13	38	2	IPR002405
Domain	-	BMP8B BMP8A GDF6	3.40e-04	67	38	3	2.10.90.10
Domain	Cystine-knot_cytokine	BMP8B BMP8A GDF6	3.40e-04	67	38	3	IPR029034
Domain	DAGKc	DGKH SPHK1	3.61e-04	14	38	2	SM00046
Domain	DAGK	DGKH SPHK1	4.16e-04	15	38	2	PS50146
Domain	Diacylglycerol_kinase_cat_dom	DGKH SPHK1	4.16e-04	15	38	2	IPR001206
Domain	DAGK_cat	DGKH SPHK1	4.16e-04	15	38	2	PF00781
Domain	NAD/diacylglycerol_kinase	DGKH SPHK1	5.38e-04	17	38	2	IPR016064
Domain	cEGF	LRP2 GAS6	1.27e-03	26	38	2	IPR026823
Domain	cEGF	LRP2 GAS6	1.27e-03	26	38	2	PF12662
Domain	EGF_3	LRP2 TLL1 TLL2 GAS6	1.29e-03	235	38	4	PS50026
Domain	EGF	LRP2 TLL1 TLL2 GAS6	1.29e-03	235	38	4	SM00181
Domain	ZnMc	TLL1 TLL2	1.58e-03	29	38	2	SM00235
Domain	Peptidase_Metallo	TLL1 TLL2	1.58e-03	29	38	2	IPR006026
Domain	EGF-like_dom	LRP2 TLL1 TLL2 GAS6	1.59e-03	249	38	4	IPR000742
Domain	EGF_1	LRP2 TLL1 TLL2 GAS6	1.74e-03	255	38	4	PS00022
Domain	EGF-like_CS	LRP2 TLL1 TLL2 GAS6	1.89e-03	261	38	4	IPR013032
Domain	EGF_2	LRP2 TLL1 TLL2 GAS6	2.00e-03	265	38	4	PS01186
Domain	CUB	TLL1 TLL2	4.46e-03	49	38	2	PF00431
Domain	CUB	TLL1 TLL2	4.64e-03	50	38	2	SM00042
Domain	-	TLL1 TLL2	5.01e-03	52	38	2	2.60.120.290
Domain	CUB	TLL1 TLL2	5.20e-03	53	38	2	PS01180
Domain	CUB_dom	TLL1 TLL2	6.00e-03	57	38	2	IPR000859
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST	BMP8B BMP8A GDF6	3.14e-06	15	28	3	M47824
Pathway	KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY	BMP8B BMP8A GDF6	7.82e-06	20	28	3	M47843
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	LRP2 BMP8B BMP8A	1.81e-04	56	28	3	M1053
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	TLL1 TLL2	3.93e-04	15	28	2	M27161
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	TLL1 TLL2	5.71e-04	18	28	2	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	TLL1 TLL2	5.71e-04	18	28	2	MM14882
Pathway	KEGG_TGF_BETA_SIGNALING_PATHWAY	BMP8B BMP8A GDF6	6.43e-04	86	28	3	M2642
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	DLGAP3 BMP8B BMP8A	1.97e-07	11	38	3	10721728
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	1.16e-06	2	38	2	31940275
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	1.16e-06	2	38	2	21277400
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	1.16e-06	2	38	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.16e-06	2	38	2	8682296
Pubmed	Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.	TLL1 TLL2	1.16e-06	2	38	2	11313359
Pubmed	Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19.	TLL1 TLL2	3.48e-06	3	38	2	10516436
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	3.48e-06	3	38	2	9076678
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	3.48e-06	3	38	2	10894154
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	TLL1 TLL2	3.48e-06	3	38	2	18824173
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	3.48e-06	3	38	2	12925636
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	3.48e-06	3	38	2	22579288
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	3.48e-06	3	38	2	11784057
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	3.48e-06	3	38	2	25451979
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	6.96e-06	4	38	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	6.96e-06	4	38	2	8843393
Pubmed	Mammalian tolloid proteinases: role in growth factor signalling.	TLL1 TLL2	6.96e-06	4	38	2	27391803
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	TLL1 TLL2	1.16e-05	5	38	2	10479448
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	1.74e-05	6	38	2	9878243
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP8B BMP8A	1.74e-05	6	38	2	7605753
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	2.43e-05	7	38	2	9070944
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	2.43e-05	7	38	2	12107726
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	BMP8B BMP8A GDF6	3.04e-05	55	38	3	15342483
Pubmed	Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.	BMP8B BMP8A	4.16e-05	9	38	2	15028287
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP8B BMP8A	4.16e-05	9	38	2	1460021
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	BMP8B NR2E3 BMP8A	6.00e-05	69	38	3	30352686
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP8B BMP8A	9.00e-05	13	38	2	18391523
Pubmed	New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.	BMP8B BMP8A	1.05e-04	14	38	2	11526197
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	BMP8B BMP8A	1.38e-04	16	38	2	19272164
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	LRP2 XPNPEP1 ARSB FOLH1 TKT GSTA5 GAS6	1.40e-04	1070	38	7	23533145
Pubmed	Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.	BMP8B BMP8A	1.56e-04	17	38	2	14736746
Pubmed	Dysfunction of programmed embryo senescence is linked to genetic developmental defects.	BMP8B BMP8A	1.76e-04	18	38	2	37017267
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	LRP2 DNAH5 TLL1	1.81e-04	100	38	3	25807483
Pubmed	Novel interactors and a role for supervillin in early cytokinesis.	HAX1 STARD9	4.32e-04	28	38	2	20309963
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	LRP2 DLGAP3 BMP8B GABBR1	4.50e-04	329	38	4	17474147
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	PEAK3 FARS2	4.63e-04	29	38	2	21998595
Pubmed	Forkhead box a2 (FOXA2) is essential for uterine function and fertility.	BMP8B BMP8A	6.01e-04	33	38	2	28049832
Pubmed	Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.	BMP8B BMP8A	6.01e-04	33	38	2	32640236
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SRRT CMTR2 CHTF18 TBC1D5 TLL1	6.77e-04	650	38	5	38777146
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	DLGAP3 BMP8B BMP8A	1.86e-03	294	38	3	chr1p34
GeneFamily	Bone morphogenetic proteins\|Astacins	TLL1 TLL2	2.52e-05	6	24	2	894
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	9.22e-05	11	24	2	455
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3	BMP8B BMP8A SPHK1 GDF6	1.97e-06	62	38	4	MM829
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LRP2 DNAH5 TLL1 ICA1	2.08e-05	191	38	4	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LRP2 DNAH5 TLL1 ICA1	2.16e-05	193	38	4	b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LRP2 DNAH5 TLL1 ICA1	2.16e-05	193	38	4	b38aaffbea36ef6c08ebe82675438f873c89b242
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LRP2 DNAH5 TLL1 ICA1	2.21e-05	194	38	4	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LRP2 DNAH5 TLL1 ICA1	2.21e-05	194	38	4	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B BMP8A ICA1	4.63e-06	26	37	3	DOID:9351 (implicated_via_orthology)
Disease	nicotine dependence	DLGAP3 HAX1 GABBR1	1.29e-04	78	37	3	EFO_0003768
Disease	obesity (implicated_via_orthology)	BMP8B BMP8A SPHK1 TBC1D5	1.50e-04	215	37	4	DOID:9970 (implicated_via_orthology)
Disease	Bipolar Disorder	SRRT DGKH STARD9 TLL2 CRY1	3.08e-04	477	37	5	C0005586
Disease	bipolar disorder	DGKH XPNPEP1 HAX1 CMTR2 STARD9	7.30e-04	577	37	5	MONDO_0004985
Disease	Nodular glomerulosclerosis	DGKH GAS6	1.22e-03	41	37	2	C0017667
Disease	Diabetic Nephropathy	DGKH GAS6	1.40e-03	44	37	2	C0011881
Disease	blood urea nitrogen measurement	LRP2 DGKH WDR90 GSTA5	2.41e-03	452	37	4	EFO_0004741
Disease	thyroxine measurement	AADAT STARD9	4.88e-03	83	37	2	EFO_0005130

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGAVCVALDWLAFDD	CHTF18	666	Q8WVB6
VALDWLAFDDLLAGA	CHTF18	671	Q8WVB6
DAILAAADKWLTGLA	AADAT	331	Q8N5Z0
LAAAEWAALAWELLG	ANKLE2	6	Q86XL3
LKGALLDFLWDLNAA	CMTR2	731	Q8IYT2
YLQLADDGLVALDWV	ABHD15	126	Q6UXT9
ILLEEAWSELFLLGA	NR2E3	251	Q9Y5X4
WLLAAAGVELEEKFL	GSTA5	21	Q7RTV2
LDDAFSILDLFLGRW	HAX1	261	O00165
VLDAADRSADWLGLF	NUDT19	66	A8MXV4
GEGLDDTLADFWAQL	GPC2	156	Q8N158
EAPLAYDAIWALALA	GABBR1	466	Q9UBS5
ILFASWDAEEFGLLG	FOLH1	416	Q04609
ALKFLEAWGAALVEL	PEAK3	291	Q6ZS72
WLDARLDGLFVSDLN	LRP2	3286	P98164
VAAWLDLLNLGEYKD	DGKH	1156	Q86XP1
AADTGVLFALWAPDL	GAS6	516	Q14393
FEELLLDADWSINAG	CRY1	381	Q16526
DLAGFWDLLQLSIED	DLGAP3	871	O95886
FLDLQTLRAGDEGWL	BMP8A	181	Q7Z5Y6
HLVFLLADDLGWNDV	ARSB	46	P15848
AEAWEGAAVAQDLLA	FAM98C	6	Q17RN3
FLDLQTLRAGDEGWL	BMP8B	181	P34820
FALLWSAGAALELDG	DNAH5	2486	Q8TE73
DLTAWFSLFADLDPL	ICA1	451	Q05084
LELRAAWGELDAGEA	GDF6	231	Q6KF10
AAVFWGDIALDDEDL	TLL1	56	O43897
LEWLDLDGDLAASRL	STARD9	601	Q9P2P6
GWFDNLLLDIDKADA	SRRT	231	Q9BXP5
DAPENVELALAEFWA	STK35	236	Q8TDR2
VLSAGDAVFLWDVLA	WDR90	986	Q96KV7
ALDEIAWLFNLRGSD	XPNPEP1	201	Q9NQW7
WAEAGFLAEAELLNL	TKT	86	P29401
FWGDIALDEDDLKLF	TLL2	61	Q9Y6L7
DFAAFLLQGAGDIWL	WDR93	206	Q6P2C0
VLSLAWGFIADVDLE	SPHK1	166	Q9NYA1
QDLLVVWDALFADGL	TBC1D5	346	Q92609
WDLLHAGLDAFLVVG	FARS2	161	O95363
AAFLLDLGTDLWAAV	XKR8	21	Q9H6D3