Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

EPRS1 NSUN6 NSUN3 MRPL44 MOV10L1 APEX1 TRMT13 ERN2 TDP2

1.54e-04417949GO:0140098
GeneOntologyMolecularFunctiontRNA (cytidine-5-)-methyltransferase activity

NSUN6 NSUN3

2.17e-045942GO:0016428
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

BLM EPRS1 NSUN6 NSUN3 MRPL44 MOV10L1 APEX1 TRMT13 RFC1 ERN2 TDP2

2.23e-046459411GO:0140640
GeneOntologyMolecularFunctionprotein serine kinase activity

RPS6KA5 PIK3CB MKNK2 MAP3K9 SNRK PRKDC ERN2 MELK

3.16e-04363948GO:0106310
GeneOntologyMolecularFunctiontRNA methyltransferase activity

NSUN6 NSUN3 TRMT13

5.44e-0434943GO:0008175
GeneOntologyMolecularFunctionATP-dependent activity

BLM ABCF3 SPG7 CENPE SLC27A1 ATAD2B MOV10L1 RFC1 DNAH5 NLRP3

6.24e-046149410GO:0140657
GeneOntologyBiologicalProcessmitochondrial translational elongation

MRPL44 GFM1 TUFM

8.53e-075923GO:0070125
GeneOntologyBiologicalProcesstRNA C5-cytosine methylation

NSUN6 NSUN3

1.97e-052922GO:0002946
DomainANK

POTEB3 POTED ANKRD11 POTEB2 POTEB POTEC NOTCH3

2.58e-04251937SM00248
DomainANK_REPEAT

POTEB3 POTED ANKRD11 POTEB2 POTEB POTEC NOTCH3

2.71e-04253937PS50088
DomainANK_REP_REGION

POTEB3 POTED ANKRD11 POTEB2 POTEB POTEC NOTCH3

2.78e-04254937PS50297
DomainAnkyrin_rpt

POTEB3 POTED ANKRD11 POTEB2 POTEB POTEC NOTCH3

3.35e-04262937IPR002110
DomainNOL1_NOP2_SUN

NSUN6 NSUN3

3.63e-046932PS01153
DomainRCMT

NSUN6 NSUN3

3.63e-046932IPR023267
DomainSAM_MT_RSMB_NOP

NSUN6 NSUN3

5.07e-047932PS51686
DomainMeTrfase_RsmB/NOP2

NSUN6 NSUN3

6.74e-048932IPR001678
DomainMethyltr_RsmB-F

NSUN6 NSUN3

6.74e-048932PF01189
DomainAAA

ABCF3 SPG7 ATAD2B RFC1 DNAH5

7.66e-04144935SM00382
DomainAAA+_ATPase

ABCF3 SPG7 ATAD2B RFC1 DNAH5

7.66e-04144935IPR003593
DomainG_TR_CS

GFM1 TUFM

8.63e-049932IPR031157
DomainP-loop_NTPase

BLM MPP1 ABCF3 SPG7 CENPE ATAD2B MOV10L1 RFC1 GFM1 DNAH5 TUFM NLRP3

1.01e-038489312IPR027417
DomainAnkyrin_rpt-contain_dom

POTEB3 ANKRD11 POTEB2 POTEB POTEC NOTCH3

1.69e-03254936IPR020683
DomainG_TR_1

GFM1 TUFM

1.85e-0313932PS00301
DomainAAA

SPG7 ATAD2B RFC1

2.21e-0352933PF00004
DomainATPase_AAA_core

SPG7 ATAD2B RFC1

2.47e-0354933IPR003959
DomainPI3/4_kinase_CS

PIK3CB PRKDC

2.47e-0315932IPR018936
Domain-

PIK3CB PRKDC

2.81e-03169321.10.1070.11
DomainPI3Kc

PIK3CB PRKDC

2.81e-0316932SM00146
Domain-

NSUN6 NSUN3 ASMTL AS3MT

3.05e-031209343.40.50.150
DomainSAM-dependent_MTases

NSUN6 NSUN3 ASMTL AS3MT

3.23e-03122934IPR029063
DomainPI3_PI4_kinase

PIK3CB PRKDC

3.56e-0318932PF00454
DomainEFTu-like_2

GFM1 TUFM

3.56e-0318932IPR004161
DomainPI3_4_KINASE_1

PIK3CB PRKDC

3.56e-0318932PS00915
DomainPI3_4_KINASE_2

PIK3CB PRKDC

3.56e-0318932PS00916
DomainPI3/4_kinase_cat_dom

PIK3CB PRKDC

3.56e-0318932IPR000403
DomainPI3_4_KINASE_3

PIK3CB PRKDC

3.56e-0318932PS50290
DomainGTP_EFTU_D2

GFM1 TUFM

3.56e-0318932PF03144
DomainG_TR_2

GFM1 TUFM

3.56e-0318932PS51722
Domain-

BLM MPP1 ABCF3 SPG7 ATAD2B MOV10L1 RFC1 GFM1 DNAH5 TUFM

3.96e-0374693103.40.50.300
DomainTF_GTP-bd_dom

GFM1 TUFM

3.97e-0319932IPR000795
DomainUBA-like

UBQLN3 ASCC2 TDP2

4.00e-0364933IPR009060
DomainApc4_WD40_dom

WRAP73 WDR55

4.40e-0320932IPR024977
DomainANAPC4_WD40

WRAP73 WDR55

4.40e-0320932PF12894
DomainAnk_2

POTEB3 ANKRD11 POTEB2 POTEC NOTCH3

4.42e-03215935PF12796
DomainCa/CaM-dep_Ca-dep_prot_Kinase

MKNK2 SNRK MELK

4.94e-0369933IPR020636
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTED POTEB2 POTEB POTEC

7.60e-12895512475935
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

MPP1 EPRS1 DACT1 ZNF605 SPG7 RPS6KA5 PIK3CB MRPL44 DUSP8 APEX1 ROBO2 SEC31A JADE1 RFC1 TDP2 NOTCH3 ZNF71

9.71e-091124951721900206
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 DACT1 SEPHS2 PWWP2B SPG7 PER2 ANKRD11 SPATA20 PRKDC JADE1 PLEC ZZEF1 GCN1 PLXNA1 MADD KCNH3

5.08e-081105951635748872
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEB2 POTEB POTEC

3.93e-07695317171436
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEB3 POTED POTEB

6.86e-07795315276201
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

MYT1L NPC1 EPRS1 ZNF605 FEZF2 MCF2L2 ADNP2 PRKDC SEC31A PLEC CMYA5 USP9Y TDP2 MADD ZNF292

2.08e-061285951535914814
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

NPC1 GLG1 MRPL44 PLEC DNAH5 TUFM NOTCH3

2.11e-0621495722199357
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

EPRS1 MRPL44 KIAA0586 SF3A3 PSMD8 PRKDC SEC31A RFC1 CMYA5 F2 GFM1 DNAH5 GCN1 PLXNA1 TUFM

7.26e-061425951530948266
Pubmed

Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations.

F2 F5

7.38e-06295211836168
Pubmed

Thrombophilic mutations are a main risk factor for placental abruption.

F2 F5

7.38e-06295212857557
Pubmed

Hemiplegic cerebral palsy and the factor V Leiden mutation.

F2 F5

7.38e-06295211183183
Pubmed

Prevalence of factor V Leiden and prothrombin G20210A gene mutation.

F2 F5

7.38e-06295215900364
Pubmed

Risk factors for catheter-related thrombosis in cancer patients.

F2 F5

7.38e-06295215454250
Pubmed

Family history for venous thromboembolism and the risk for recurrence.

F2 F5

7.38e-06295216431184
Pubmed

Prothrombotic gene mutations and Crohn's disease; is there any association?

F2 F5

7.38e-06295216201098
Pubmed

Low frequency of factor V Leiden and prothrombin G20210A mutations in patients with hepatic venous outflow tract obstruction in northern India: a case-control study.

F2 F5

7.38e-06295216361766
Pubmed

High incidence of factor V Leiden and prothrombin G20210A in healthy southern Italians.

F2 F5

7.38e-06295219211580
Pubmed

Thrombophilic risk factors in epileptic children treated with valproic Acid.

F2 F5

7.38e-06295219135623
Pubmed

Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency.

F2 F5

7.38e-06295216469858
Pubmed

Effect of Factor V Leiden and prothrombin G20210-->A mutations on thromboembolic risk in the national surgical adjuvant breast and bowel project breast cancer prevention trial.

F2 F5

7.38e-06295216818854
Pubmed

Are factor V and prothrombin mutations associated with increased risk of oral cancer?

F2 F5

7.38e-06295216080493
Pubmed

Role of factor V Leiden or G20210A prothrombin mutation in patients with symptomatic pulmonary embolism and deep vein thrombosis: a meta-analysis of the literature.

F2 F5

7.38e-06295222329698
Pubmed

Regulation of factor V and factor V-short by TFPIα: Relationship between B-domain proteolysis and binding.

F2 F5

7.38e-06295233376137
Pubmed

Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis.

F2 F5

7.38e-06295218752569
Pubmed

Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease.

F2 F5

7.38e-06295211741359
Pubmed

Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: a rational approach to contraception.

F2 F5

7.38e-06295221659542
Pubmed

Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis.

F2 F5

7.38e-06295218285537
Pubmed

Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate?

F2 F5

7.38e-06295221259017
Pubmed

Evaluation of Factor V Leiden and prothrombin G20210A mutations in Sudanese women with severe preeclampsia.

F2 F5

7.38e-06295231501046
Pubmed

Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years.

F2 F5

7.38e-06295215947254
Pubmed

Contribution of prothrombin 20210A allele and factor V Leiden mutation to thrombosis risk in thrombophilic families with other hemostatic deficiencies.

F2 F5

7.38e-06295211694407
Pubmed

[Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis].

F2 F5

7.38e-06295216446869
Pubmed

Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis.

F2 F5

7.38e-06295218462012
Pubmed

Association of maternal and/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction.

F2 F5

7.38e-06295212725641
Pubmed

Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis.

F2 F5

7.38e-06295219404532
Pubmed

Inherited thrombophilias and unexplained pregnancy loss: an incident case-control study.

F2 F5

7.38e-06295219036071
Pubmed

Factor v leiden mutation in patients with breast cancer with a central venous catheter: risk of deep vein thrombosis.

F2 F5

7.38e-06295218632446
Pubmed

Association between thrombophilia gene polymorphisms and preeclampsia: a meta-analysis.

F2 F5

7.38e-06295224967675
Pubmed

Factor V Leiden and prothrombin 20210 G-A mutations in controls and in patients with thromboembolic events during pregnancy or the puerperium.

F2 F5

7.38e-06295214504875
Pubmed

Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis.

F2 F5

7.38e-06295211886391
Pubmed

Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations.

F2 F5

7.38e-06295217439630
Pubmed

Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes.

F2 F5

7.38e-06295224282370
Pubmed

Prothrombotic factors and the risk of acute onset non-cardioembolic stroke in young Asian Indians.

F2 F5

7.38e-06295219560187
Pubmed

Inherited thrombophilic abnormalities and risk of portal vein thrombosis. a meta-analysis.

F2 F5

7.38e-06295218392325
Pubmed

Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia.

F2 F5

7.38e-06295217067362
Pubmed

Sclerotherapy of varicose veins in patients with documented thrombophilia: a prospective controlled randomized study of 105 cases.

F2 F5

7.38e-06295219620700
Pubmed

A whole-blood homogeneous assay for the multiplex detection of the factor V G1691A and the prothrombin G20210A mutations.

F2 F5

7.38e-06295216006096
Pubmed

Potential prevention of thromboembolism by genetic counseling and testing for two common thrombophilia mutations.

F2 F5

7.38e-06295222210734
Pubmed

Clinical evaluation of a functional prothrombin time-based assay for identification of factor V Leiden carriers in a group of Italian patients with venous thrombosis.

F2 F5

7.38e-06295217890946
Pubmed

Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study.

F2 F5

7.38e-06295218983482
Pubmed

Duration of anticoagulation and risk of recurrent thromboembolism in carriers of factor V Leiden or prothrombin mutation.

F2 F5

7.38e-06295218983490
Pubmed

Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome.

F2 F5

7.38e-06295212519104
Pubmed

Lack of association between hemorheological alterations and upper-extremity deep vein thrombosis.

F2 F5

7.38e-06295219318721
Pubmed

Thrombophilic mutations in high-risk atrial fibrillation patients: high prevalence of prothrombin gene G20210A polymorphism and lack of correlation with thromboembolism.

F2 F5

7.38e-06295214652651
Pubmed

Upper extremity deep venous thrombosis in the population-based Malmö thrombophilia study (MATS). Epidemiology, risk factors, recurrence risk, and mortality.

F2 F5

7.38e-06295220406709
Pubmed

[Venous thromboembolic events in surgery: a role of genetic disorders].

F2 F5

7.38e-06295218368843
Pubmed

Polymorphisms in factor II and factor VII genes modulate oral anticoagulation with warfarin.

F2 F5

7.38e-06295215590403
Pubmed

Meta-analysis of factor V Leiden and prothrombin G20210A polymorphism in migraine.

F2 F5

7.38e-06295225158985
Pubmed

Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons.

F2 F5

7.38e-06295212088785
Pubmed

G1691A factor V and G20210A FII mutations, acute ischemic stroke of unknown cause, and patent foramen ovale.

F2 F5

7.38e-06295222909823
Pubmed

Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone.

F2 F5

7.38e-06295214531916
Pubmed

Factor VLeiden and prothrombin G20210A gene polymorphisms in patients with coronary artery disease.

F2 F5

7.38e-06295218452260
Pubmed

Markers of activated coagulation in patients with factor V Leiden and/or G20210A prothrombin gene mutation.

F2 F5

7.38e-06295212413582
Pubmed

Genetic and acquired thrombotic factors in chronic hepatitis C.

F2 F5

7.38e-06295215056097
Pubmed

Absence of factor V Leiden (G1691A) mutation, FII G20210A allele in coronary artery disease in North India.

F2 F5

7.38e-06295214701945
Pubmed

G20210A prothrombin mutation and critical limb ischaemia in patients with peripheral arterial disease.

F2 F5

7.38e-06295219356951
Pubmed

Factor V Leiden as a risk factor for preterm birth--a population-based nested case-control study.

F2 F5

7.38e-06295220946152
Pubmed

[High-risk factors and clinical pathological analysis in 21 cases of fatal pulmonary embolism].

F2 F5

7.38e-06295220019774
Pubmed

Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke.

F2 F5

7.38e-06295215116266
Pubmed

The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies.

F2 F5

7.38e-06295220563311
Pubmed

Thrombophilic polymorphism--a short-term or long-term risk for recurrence?

F2 F5

7.38e-06295218983501
Pubmed

Factor V Leiden and prothrombin G20210A polymorphisms are not associated with disease-free survival in breast cancer.

F2 F5

7.38e-06295218777205
Pubmed

Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis.

F2 F5

7.38e-06295218983518
Pubmed

Thrombophilic screening in retinal artery occlusion patients.

F2 F5

7.38e-06295219668753
Pubmed

Risk of recurrent venous thrombosis in homozygous carriers and double heterozygous carriers of factor V Leiden and prothrombin G20210A.

F2 F5

7.38e-06295220368522
Pubmed

Comparative study between the Light Cycler and the PCR-restriction fragment length polymorphism in detecting factor V Leiden and factor II 20210G>A mutations.

F2 F5

7.38e-06295216563366
Pubmed

Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population.

F2 F5

7.38e-06295219524925
Pubmed

Risk factors for peripheral venous disease resemble those for venous thrombosis: the San Diego Population Study.

F2 F5

7.38e-06295220492466
Pubmed

Homozygous and double heterozygous Factor V Leiden and Factor II G20210A genotypes predispose infants to thromboembolism but are not associated with an increase of foetal loss.

F2 F5

7.38e-06295214515183
Pubmed

Prothrombin 20210GA and factor V Leiden mutations in patients less than 55 years old with myocardial infarction.

F2 F5

7.38e-06295215240970
Pubmed

Low prevalence of coagulation F2 and F5 polymorphisms in mothers and children in a large cohort of patients with neonatal arterial ischemic stroke.

F2 F5

7.38e-06295220528875
Pubmed

Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism.

F2 F5

7.38e-06295212749008
Pubmed

Thromboembolism in heart transplantation: role of prothrombin G20210A and factor V Leiden.

F2 F5

7.38e-06295216177630
Pubmed

Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery.

F2 F5

7.38e-06295212008938
Pubmed

Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and obstetric complications.

F2 F5

7.38e-06295220937743
Pubmed

Inherited and acquired risk factors for venous thromboembolic disease among women taking tamoxifen to prevent breast cancer.

F2 F5

7.38e-06295214512389
Pubmed

Factor V Leiden and prothrombin 20210G>A [corrected] mutation and paediatric ischaemic stroke: a case-control study and two meta-analyses.

F2 F5

7.38e-06295220337781
Pubmed

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.

NPC1 NLRP3

7.38e-06295230054450
Pubmed

The factor V G1691A, factor V H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery disease.

F2 F5

7.38e-06295219609209
Pubmed

A preliminary study on the role of inherited prothrombotic risk factors in Taiwanese patients with sudden sensorineural hearing loss.

F2 F5

7.38e-06295221170721
Pubmed

Lack of association between factor V Leiden and prothrombin G20210A polymorphisms in Tunisian subjects with a history of myocardial infarction.

F2 F5

7.38e-06295222483732
Pubmed

Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test.

F2 F5

7.38e-06295212152677
Pubmed

Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: a possible survival advantage?

F2 F5

7.38e-06295222627863
Pubmed

Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal women.

F2 F5

7.38e-06295216973976
Pubmed

Multilocus genetic risk scores for venous thromboembolism risk assessment.

F2 F5

7.38e-06295225341889
Pubmed

Factor V Leiden and G20210A prothrombin mutation and the risk of subclavian vein thrombosis in patients with breast cancer and a central venous catheter.

F2 F5

7.38e-06295215033664
Pubmed

Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial.

F2 F5

7.38e-06295218791166
Pubmed

Prevalence and significance of two major inherited thrombophilias in infective endocarditis.

F2 F5

7.38e-06295225711313
Pubmed

Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovale.

F2 F5

7.38e-06295217525392
Pubmed

The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis.

F2 F5

7.38e-06295217537362
InteractionPOTED interactions

POTEB3 POTED POTEC

4.05e-074953int:POTED
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTED POTEB2 POTEB POTEC

1.13e-0713664685
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ADNP2 ZFHX2 TSHZ1

2.05e-0515663529
GeneFamilyAnkyrin repeat domain containing

POTED ANKRD11 POTEB2 POTEB POTEC NOTCH3

2.51e-04242666403
GeneFamilyNOP2/Sun RNA methyltransferase family

NSUN6 NSUN3

2.72e-047662664
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA5 MKNK2

7.07e-04116621156
GeneFamilyAAA ATPases

SPG7 ATAD2B RFC1

9.55e-0453663413
CoexpressionGSE360_DC_VS_MAC_B_MALAYI_HIGH_DOSE_UP

RAB3GAP1 RPS6KA5 ASMTL KCNQ1 PRKDC PLEC ZZEF1 TUFM

6.88e-07200958M5185
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

BLM EPRS1 FBXO5 PIK3CB PRKDC PLEC MELK GCN1

3.64e-06250958M11318
CoexpressionGSE29618_PRE_VS_DAY7_FLU_VACCINE_MONOCYTE_DN

PER2 CENPE JADE1 GFM1 MELK GCN1 TDP2

8.22e-06199957M4977
CoexpressionWIERENGA_PML_INTERACTOME

PRKDC PLEC DNAH5 GCN1

1.63e-0542954M2219
ToppCellNon-neuronal-Dividing-IPC-IPC-div2|World / Primary Cells by Cluster

BLM IGSF10 RASGRP1 FBXO5 CENPE MELK

4.76e-062009664923d7a4f00853c4d76fc1cc0fa82d522a2302e7
ToppCellNon-neuronal-Dividing-IPC-IPC-div2-5|World / Primary Cells by Cluster

BLM IGSF10 RASGRP1 FBXO5 CENPE MELK

4.76e-06200966dc1c1506823eaa105f1532c6b5d4efa14e788314
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BLM NBAS RASGRP1 MAGEB10 TRMT13

2.09e-05154965ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLM FBXO5 RPS6KA5 CENPE MELK

3.36e-05170965b04e2f84024baaae9b4ff19bdac8c69afdb92a76
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM FBXO5 RPS6KA5 CENPE MELK

3.65e-0517396531784679190fbd95fc23d7c66008eb21b8c7cc5d
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|Endothelial_cells / Location, Cell class and cell subclass

NSUN3 PDSS1 KIAA0586 MAP3K9 ZFHX2

3.86e-05175965f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO5 CENPE DUSP8 MELK NOTCH3

3.97e-0517696545c6983ab671b0f306e7390320bd84f848e474cc
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYT1L FBXO5 CENPE SHE MELK

3.97e-051769658385435074cc5235b7af7424974f609388fc2cff
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF605 CENPE MCF2L2 FKBPL F5

4.19e-051789658b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BLM RASGRP1 FBXO5 CENPE MELK

4.77e-0518396529b62dd542bc3f8df843998f577724f3818d4271
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

NPC1 NBAS EPRS1 PRKDC ZNF292

5.03e-05185965a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FBXO5 CENPE MELK GCN1 ZNF71

5.16e-05186965799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

NPC1 NBAS EPRS1 PRKDC ZNF292

5.16e-051869658571956890fc9894d766ba294a28e376b4aba428
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RASGRP1 GLG1 ZZEF1 F5 GCN1

5.29e-051879654527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPE PDSS1 AS3MT KCNQ1 MELK

5.56e-0518996545b9d00a4968fb22207d95228cdcf022afe1e50b
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPE PDSS1 AS3MT KCNQ1 MELK

5.56e-051899658382d331e01e83591ba9c8ea83edbf2436c18b17
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GLG1 ANKRD11 ROBO2 SNRK JADE1

5.70e-05190965d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

BLM RASGRP1 FBXO5 CENPE MELK

5.85e-05191965bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBXO5 CENPE KLRG2 ERN2 MELK

5.85e-05191965c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FBXO5 CENPE KIAA0586 JADE1 MELK

5.85e-051919650ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

NPC1 EPRS1 PIK3CB MRPL44 GFM1

5.99e-051929654e689bca7a242f8482e25f273656e2caba8821c0
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP126 PER2 PIK3CB CBARP

6.03e-059896495162072f3afc95e46f29db3d79ebd930bc09726
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBXO5 CENPE ROBO2 JADE1 MELK

6.14e-05193965a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L RASGRP1 ROBO2 CBARP KCNH3

6.14e-05193965461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L RASGRP1 ROBO2 CBARP KCNH3

6.14e-051939650dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RPS6KA5 ATAD2B MCF2L2 USP9Y ZNF292

6.14e-051939659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L RASGRP1 ROBO2 CBARP KCNH3

6.45e-05195965ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD11 ROBO2 TSHZ1 SEC31A MADD

6.45e-051959653e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD11 ROBO2 TSHZ1 SEC31A MADD

6.45e-051959657796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IGSF10 FBXO5 CENPE ROBO2 TSHZ1

6.93e-05198965148f5fee19ea8dff7f2de4ca69c3b03e5221985d
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NPC1 ATAD2B ANKRD11 USP9Y ZNF292

7.10e-05199965f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

RASGRP1 FEZF2 ADNP2 JADE1 NOTCH3

7.10e-05199965358c4b3037f59378db8916a2fbe9ed4830cf1449
Drugprednimustine

NPC1 BLM PLXNA1

3.64e-068933CID000034457
DiseaseMesenteric Venous Thrombosis

F2 F5

8.79e-062882C0267412
DiseaseMesenteric vascular insufficiency

F2 F5

8.79e-062882C1412000
DiseaseOcclusive Mesenteric Arterial Ischemia

F2 F5

8.79e-062882C3852985
DiseaseAcute Mesenteric Arterial Embolus

F2 F5

8.79e-062882C3852984
DiseaseAcute Mesenteric Arterial Thrombosis

F2 F5

8.79e-062882C3852987
DiseaseNonocclusive Mesenteric Ischemia

F2 F5

8.79e-062882C3852986
Diseasemean fractional anisotropy measurement

DACT1 DUSP8 ANKRD11 PLEC ZZEF1

9.87e-0695885EFO_0008399
DiseaseImmunologic Deficiency Syndromes

BLM NBAS RASGRP1

4.35e-0523883C0021051
DiseaseSTROKE, ISCHEMIC

F2 F5

8.74e-055882601367
DiseaseIschemic stroke

F2 F5

8.74e-055882cv:C0948008
Diseasepulmonary embolism (is_implicated_in)

F2 F5

8.74e-055882DOID:9477 (is_implicated_in)
Diseaseretinal vein occlusion (is_implicated_in)

F2 F5

1.83e-047882DOID:1727 (is_implicated_in)
DiseaseCombined oxidative phosphorylation deficiency

MRPL44 GFM1 TUFM

1.85e-0437883cv:C4540031
Diseaseblood cobalt measurement

KCNQ1 ROBO2 F5 NLRP3

2.42e-04101884EFO_0007577
DiseaseVenous Thromboembolism

F2 F5

2.43e-048882C1861172
DiseaseThrombophilia due to thrombin defect

F2 F5

2.43e-048882cv:C3160733
Diseasethrombosis (implicated_via_orthology)

PIK3CB F2

3.90e-0410882DOID:0060903 (implicated_via_orthology)
Diseaseosteonecrosis (is_implicated_in)

F2 F5

3.90e-0410882DOID:10159 (is_implicated_in)
DiseasePosterior Choroidal Artery Infarction

F2 F5

4.75e-0411882C0887799
DiseaseCerebral Infarction, Left Hemisphere

F2 F5

4.75e-0411882C0751010
DiseaseAnterior Choroidal Artery Infarction

F2 F5

4.75e-0411882C0751012
DiseaseCerebral Infarction, Right Hemisphere

F2 F5

4.75e-0411882C0751011
DiseaseSubcortical Infarction

F2 F5

4.75e-0411882C0751014
DiseaseCerebral Infarction

F2 F5

4.75e-0411882C0007785
Diseasesusceptibility to bacterial meningitis measurement

NSUN3 KCNQ1 DNAH5

5.10e-0452883EFO_0008411
DiseaseThromboembolism

F2 F5

5.69e-0412882C0040038
DiseaseCerebrovascular accident

F2 F5 NOTCH3

8.54e-0462883C0038454
Diseasethrombosis (is_implicated_in)

F2 F5

9.00e-0415882DOID:0060903 (is_implicated_in)
DiseaseBlood Coagulation Disorders

F2 F5

1.03e-0316882C0005779
DiseaseIschemic stroke, venous thromboembolism, stroke, Abnormal thrombosis, deep vein thrombosis, pulmonary embolism

F2 F5

1.16e-0317882EFO_0000712, EFO_0003827, EFO_0003907, EFO_0004286, HP_0001977, HP_0002140
Diseasewellbeing measurement, alcohol consumption measurement

DACT1 KIAA0586 CMYA5

1.43e-0374883EFO_0007869, EFO_0007878
Diseasecolorectal adenoma (is_marker_for)

SEPHS2 F5

1.61e-0320882DOID:0050860 (is_marker_for)
Diseasesexual dimorphism measurement

NPC1 SPG7 ATAD2B SF3A3 ANKRD11 KCNQ1 PLEC ZZEF1 GCN1 MADD

1.68e-0311068810EFO_0021796
DiseaseDeep Vein Thrombosis

F2 F5

1.78e-0321882C0149871
Diseaseprothrombin time measurement

F2 F5

1.78e-0321882EFO_0008390
DiseaseVenous Thrombosis

F2 F5

1.78e-0321882C0042487
DiseaseMyasthenic Syndromes, Congenital

PLEC CHRNG

2.33e-0324882C0751882
DiseaseAttention deficit hyperactivity disorder

AS3MT ZNF292

2.33e-0324882C1263846
Diseasepre-eclampsia (is_implicated_in)

F2 F5

2.52e-0325882DOID:10591 (is_implicated_in)
DiseaseVaricose veins

GLG1 DUSP8 APEX1 CMYA5

2.70e-03193884HP_0002619
DiseaseNeurodevelopmental Disorders

MYT1L ANKRD11 ZNF292

2.74e-0393883C1535926
Diseasealcohol use disorder (implicated_via_orthology)

PIK3CB NOTCH3 MADD CHRNG

2.80e-03195884DOID:1574 (implicated_via_orthology)
Diseasecorpus callosum mid-anterior volume measurement

DUSP8 PLEC

2.94e-0327882EFO_0010297

Protein segments in the cluster

PeptideGeneStartEntry
GLCVLPSGSVLDKLA

CBARP

656

Q8N350
LGSSGCLKGSPLVLK

ANKRD11

496

Q6UB99
CLKGSPLVLKDPSLF

ANKRD11

501

Q6UB99
KLCKLDSPSGAALGL

DUSP8

421

Q13202
AALEKLEKGPELGLS

CHRNG

411

P07510
KDLLPDLGEGFILAC

ASCC2

476

Q9H1I8
KDALAKNSPGLCLKI

RASGRP1

111

O95267
DCGTKLPGLLKREQS

ABCF3

101

Q9NUQ8
LKGLASRKPLVLCGD

APEX1

196

P27695
IGLDSCKELLKDLKG

ADNP2

26

Q6IQ32
CKELLKDLKGFDPGE

ADNP2

31

Q6IQ32
SGLLDIFKSKIGCPL

RAB3GAP1

206

Q15042
KNKCGLTPLLLGVHE

POTEB2

231

H3BUK9
LAILGKGDLIGCELP

KCNH3

636

Q9ULD8
LKLIDFGLCAKPKGN

MELK

146

Q14680
LDLCAAPGGKSIALL

NSUN3

136

Q9H649
GSAGLAKKCPFSLEL

KCNQ1

26

P51787
DCCSERLLGKKLGIP

MADD

201

Q8WXG6
ICDGKNPGRCKELLL

MOV10L1

416

Q9BXT6
LGCDAKLSDETGVPK

MAGEB10

186

Q96LZ2
LLGLTGNHLKCLPKE

LRRIQ4

146

A6NIV6
PKLSDAFLGELAEKC

ATAD2B

591

Q9ULI0
CKPGAGLLLVETLLD

ASMTL

546

O95671
VVLSDFGLCKKLPAG

ERN2

656

Q76MJ5
CPDDIGKLGKLLLHG

MCF2L2

831

Q86YR7
CGLSQEKEPFKKLGL

PER2

711

O15055
GKLSLPWLLNKELGC

PLXNA1

381

Q9UIW2
PVKICDFDLGSGIKL

MKNK2

221

Q9HBH9
GKKLTLACPGPLADS

NOTCH3

2081

Q9UM47
DLPEGAVKGLCKLFC

GCN1

41

Q92616
DLKDKPLGEGSFSIC

RPS6KA5

426

O75582
LCALEGRDPELGLKS

TUFM

221

P49411
EKILDLCAAPGGKTT

NSUN6

236

Q8TEA1
GGFLSLECEIKLAPK

NBAS

441

A2RRP1
ESKNKCGLTPLLLGV

POTEB3

266

A0JP26
PSSNDKALGLLCGKD

NPC1

166

O15118
ADAGTKKLECTLPDG

NID2

1291

Q14112
LDPALQDKCLIDLGK

GLG1

631

Q92896
DKPKLGSCCRVLALG

FKBPL

116

Q9UIM3
GDKLLLNCSATGEPK

IGSF10

1956

Q6WRI0
CKELGLEKEDAALLP

KLRG2

221

A4D1S0
IPDDKLKLLDCGNEL

BLM

386

P54132
GCPKSADLIGLLEYK

DACT1

206

Q9NYF0
DGKLLKASCKIGPLP

FBXO5

421

Q9UKT4
KLCTLEGLPLSAGKE

DCDC2B

176

A2VCK2
DLKLGLATGPVLFAC

PDSS1

326

Q5T2R2
FALEKPGKCTLHLGI

CMYA5

4046

Q8N3K9
EKLPTSGGCSALELK

AS3MT

326

Q9HBK9
DLLKASNGLCPEILG

CFAP126

101

Q5VTH2
LIPCKEAGLKFATGD

MPP1

176

Q00013
VEKGFLDACEKGPLS

GFM1

586

Q96RP9
LDACEKGPLSGHKLS

GFM1

591

Q96RP9
KETCLDLAGNPGILL

EFCAB3

126

Q8N7B9
LLDCTKKSGLFGLPP

PWWP2B

36

Q6NUJ5
GKVPKDLLCNLELEG

CENPE

706

Q02224
GFDLLEAGKCQLLPL

MAP3K9

766

P80192
LTLIKGGASLDLKAC

DNAH5

3916

Q8TE73
PGLGKSALIAALCDK

IRGQ

16

Q8WZA9
DGSQGKKLLNLCSPL

FEZF2

56

Q8TBJ5
ESKNKCGLTPLLLGV

POTEC

266

B2RU33
DKGIKLLCEGLLHPD

NLRP3

926

Q96P20
ESKNKCGLTPLLLGV

POTED

266

Q86YR6
CDKKLIAEGPGETVL

MRPL44

276

Q9H9J2
GADCLPGLLSVEEKK

TRMT13

411

Q9NUP7
LGDPCLKDLKKGDII

EPRS1

656

P07814
GPLLICQKGILHKDS

F5

1746

P12259
ALHSEGKLPKGCSVL

PIGL

166

Q9Y2B2
SKEIPKGAENCLEGL

RFC1

396

P35251
KNKCGLTPLLLGVHE

POTEB

231

A0A0A6YYL3
KEAEKSPQLGLGCLS

WRAP73

276

Q9P2S5
KCKLAGLEVLSDDPD

TDRD7

576

Q8NHU6
SEGKTLLKQPDLCGR

JADE1

606

Q6IE81
CDPGEKLDSKIGVLI

PIK3CB

116

P42338
PGCGKTLLAKAVATE

SPG7

351

Q9UQ90
GLCDSAKKDDLPELA

SNRK

406

Q9NRH2
PLAPAACISKIAKAG

LINC00615

56

Q96LM1
GCKVPQEALLKLLAG

SEPHS2

61

Q99611
GDEGCKALISFLEPK

ZFHX2

281

Q9C0A1
LGKSLIKFCSGDLGP

SLC27A1

196

Q6PCB7
CSEAELGAGLPLRLK

SPATA20

621

Q8TB22
PRSLDLLGLEKLDCG

TDP2

331

O95551
LLGLEKLDCGRFPSD

TDP2

336

O95551
LAKLCSDHPEIGIKG

ZNF292

211

O60281
VDGTALLKCKATGDP

ROBO2

431

Q9HCK4
VCLDHAKLGEGKLSP

USP9Y

1061

O00507
LCLLPLTDKAAKGGE

PLEC

3016

Q15149
KLPVLAGCLKGLSSL

PRKDC

216

P78527
LDPAKKLLLTASGDG

WDR55

176

Q9H6Y2
LTELLKKLCSGPEGG

ZZEF1

1061

O43149
KKLCSGPEGGLRKLD

ZZEF1

1066

O43149
SGEADCGLRPLFEKK

F2

331

P00734
DRLKSALLALGLKCG

SF3A3

261

Q12874
SPNLSKCGEELGRLK

PSMD8

106

P48556
ADPELLLSCGKDAKI

SEC31A

271

O94979
CEPADGGLKSETLAK

SHE

261

Q5VZ18
KLLGGSVPACHELKA

ZNF71

66

Q9NQZ8
GTGEKSLKCPFDLLI

ZNF605

96

Q86T29
AGKILKDPDSLAQCG

UBQLN3

66

Q9H347
LDDSPKGGLDILKSL

TSHZ1

541

Q6ZSZ6
EGEILFSCGQKLAPK

KIAA0586

1231

Q9BVV6
LSGCPIAAAEKLAKA

MYT1L

571

Q9UL68
KKDLITLSGCPLADK

MYT1L

876

Q9UL68