Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	small conductance calcium-activated potassium channel activity	KCNN1 KCNN3	4.62e-05	4	56	2	GO:0016286
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF280A ZNF704 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 SMARCA4 ZNF362 CDC5L ZNF865 CASZ1 CREB5	1.56e-04	1459	56	13	GO:0000977
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEE POTEI	4.18e-04	11	56	2	GO:0098973
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF280A ZNF704 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 SMARCA4 ZNF362 ZNF865 CREB5	5.83e-04	1244	56	11	GO:0000978
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	5.94e-04	372	56	6	GO:0061630
GeneOntologyMolecularFunction	protein kinase binding	TRIM49 POTEE TRIM49C PAM SPAG9 POTEI CDC5L TRIM49B RYR2	6.68e-04	873	56	9	GO:0019901
GeneOntologyMolecularFunction	calcium-activated potassium channel activity	KCNN1 KCNN3	6.88e-04	14	56	2	GO:0015269
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF280A ZNF704 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 SMARCA4 ZNF362 ZNF865 CREB5	6.98e-04	1271	56	11	GO:0000987
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	8.45e-04	398	56	6	GO:0061659
GeneOntologyMolecularFunction	kinase binding	TRIM49 POTEE TRIM49C PAM SPAG9 POTEI CDC5L TRIM49B RYR2	1.39e-03	969	56	9	GO:0019900
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	2.04e-03	473	56	6	GO:0004842
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNN1 KCNN3 GRIN3B RYR2	2.10e-03	193	56	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNN1 KCNN3 GRIN3B RYR2	2.26e-03	197	56	4	GO:0022834
GeneOntologyMolecularFunction	calcium-activated cation channel activity	KCNN1 KCNN3	2.59e-03	27	56	2	GO:0005227
GeneOntologyMolecularFunction	inward rectifier potassium channel activity	KCNN1 KCNN3	2.79e-03	28	56	2	GO:0005242
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	3.03e-03	512	56	6	GO:0019787
GeneOntologyMolecularFunction	zinc ion binding	TRIM49 IFIH1 TRIM49C TRIM49D1 PAM SIAH2 TRIM49B CA4	3.24e-03	891	56	8	GO:0008270
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNN1 KCNN3	3.41e-03	31	56	2	GO:0022839
GeneOntologyMolecularFunction	channel activity	GJB1 KCNN1 KCNN3 GRIN3B MCUB RYR2	3.42e-03	525	56	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GJB1 KCNN1 KCNN3 GRIN3B MCUB RYR2	3.46e-03	526	56	6	GO:0022803
GeneOntologyMolecularFunction	structural constituent of postsynapse	POTEE POTEI	3.63e-03	32	56	2	GO:0099186
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	3.65e-03	532	56	6	GO:0016755
GeneOntologyMolecularFunction	transcription corepressor activity	PRDM8 ZNF366 SMARCA4 SIAH2	3.88e-03	229	56	4	GO:0003714
GeneOntologyMolecularFunction	calmodulin binding	KCNN1 KCNN3 CAMK1G RYR2	3.94e-03	230	56	4	GO:0005516
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA2 SMARCA4	4.83e-03	37	56	2	GO:0140658
GeneOntologyCellularComponent	bBAF complex	SMARCA2 SMARCA4	3.24e-04	10	57	2	GO:0140092
GeneOntologyCellularComponent	npBAF complex	SMARCA2 SMARCA4	6.51e-04	14	57	2	GO:0071564
GeneOntologyCellularComponent	GBAF complex	SMARCA2 SMARCA4	6.51e-04	14	57	2	GO:0140288
GeneOntologyCellularComponent	nBAF complex	SMARCA2 SMARCA4	8.55e-04	16	57	2	GO:0071565
Domain	ZINC_FINGER_C2H2_2	ZNF280A ATMIN ZNF704 BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1 CREB5	7.80e-10	775	57	16	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF280A ATMIN ZNF704 BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1 CREB5	8.10e-10	777	57	16	PS00028
Domain	Znf_C2H2-like	ZNF280A ATMIN ZNF704 BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1 CREB5	1.15e-09	796	57	16	IPR015880
Domain	Znf_C2H2	ZNF280A ATMIN ZNF704 BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1 CREB5	1.35e-09	805	57	16	IPR007087
Domain	ZnF_C2H2	ZNF280A ATMIN ZNF704 BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1 CREB5	1.43e-09	808	57	16	SM00355
Domain	zf-C2H2	BNC1 PRDM8 ZNF280D ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 POGZ ZNF362 ZNF865 CASZ1	9.46e-07	693	57	12	PF00096
Domain	SPRY	TRIM49 TRIM49C TRIM49D1 TRIM49B RYR2	6.76e-06	87	57	5	SM00449
Domain	SnAC	SMARCA2 SMARCA4	9.15e-06	2	57	2	SM01314
Domain	Gln-Leu-Gln_QLQ	SMARCA2 SMARCA4	9.15e-06	2	57	2	IPR014978
Domain	SnAC	SMARCA2 SMARCA4	9.15e-06	2	57	2	IPR029295
Domain	SnAC	SMARCA2 SMARCA4	9.15e-06	2	57	2	PF14619
Domain	QLQ	SMARCA2 SMARCA4	9.15e-06	2	57	2	SM00951
Domain	QLQ	SMARCA2 SMARCA4	9.15e-06	2	57	2	PS51666
Domain	QLQ	SMARCA2 SMARCA4	9.15e-06	2	57	2	PF08880
Domain	SPRY	TRIM49 TRIM49C TRIM49D1 TRIM49B RYR2	9.88e-06	94	57	5	PF00622
Domain	SPRY_dom	TRIM49 TRIM49C TRIM49D1 TRIM49B RYR2	9.88e-06	94	57	5	IPR003877
Domain	B30.2/SPRY	TRIM49 TRIM49C TRIM49D1 TRIM49B RYR2	1.04e-05	95	57	5	IPR001870
Domain	B302_SPRY	TRIM49 TRIM49C TRIM49D1 TRIM49B RYR2	1.04e-05	95	57	5	PS50188
Domain	-	ZNF280A PRDM8 ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 ZNF362 ZNF865 CREB5	3.48e-05	679	57	10	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF280A PRDM8 ZNF366 ZNF652 ZNF644 ZBTB22 ZBTB47 ZNF362 ZNF865 CREB5	4.18e-05	694	57	10	IPR013087
Domain	ConA-like_dom	TRIM49 LAMA1 TRIM49C TRIM49D1 TRIM49B RYR2	5.35e-05	219	57	6	IPR013320
Domain	HSA	SMARCA2 SMARCA4	5.47e-05	4	57	2	SM00573
Domain	CaMBD	KCNN1 KCNN3	5.47e-05	4	57	2	PF02888
Domain	DUF4195	ZNF280A ZNF280D	5.47e-05	4	57	2	PF13836
Domain	CaM-bd_dom	KCNN1 KCNN3	5.47e-05	4	57	2	IPR004178
Domain	CaMBD	KCNN1 KCNN3	5.47e-05	4	57	2	SM01053
Domain	HSA	SMARCA2 SMARCA4	5.47e-05	4	57	2	PS51204
Domain	SK_channel	KCNN1 KCNN3	5.47e-05	4	57	2	PF03530
Domain	HSA_dom	SMARCA2 SMARCA4	5.47e-05	4	57	2	IPR014012
Domain	DUF4195	ZNF280A ZNF280D	5.47e-05	4	57	2	IPR025243
Domain	HSA	SMARCA2 SMARCA4	5.47e-05	4	57	2	PF07529
Domain	K_chnl_Ca-activ_SK	KCNN1 KCNN3	5.47e-05	4	57	2	IPR015449
Domain	BBOX	TRIM49 TRIM49C TRIM49D1 TRIM49B	5.81e-05	69	57	4	SM00336
Domain	Butyrophylin	TRIM49 TRIM49C TRIM49D1 TRIM49B	6.15e-05	70	57	4	IPR003879
Domain	-	TRIM49 TRIM49C TRIM49D1 TRIM49B	6.50e-05	71	57	4	4.10.45.10
Domain	zf-B_box	TRIM49 TRIM49C TRIM49D1 TRIM49B	6.87e-05	72	57	4	PF00643
Domain	ZF_BBOX	TRIM49 TRIM49C TRIM49D1 TRIM49B	1.04e-04	80	57	4	PS50119
Domain	Znf_B-box	TRIM49 TRIM49C TRIM49D1 TRIM49B	1.09e-04	81	57	4	IPR000315
Domain	BRK	SMARCA2 SMARCA4	1.36e-04	6	57	2	SM00592
Domain	BRK_domain	SMARCA2 SMARCA4	1.36e-04	6	57	2	IPR006576
Domain	BRK	SMARCA2 SMARCA4	1.36e-04	6	57	2	PF07533
Domain	ZF_RING_2	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	2.87e-04	298	57	6	PS50089
Domain	RING	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	3.25e-04	305	57	6	SM00184
Domain	Znf_RING	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	4.63e-04	326	57	6	IPR001841
Domain	Actin_CS	POTEE POTEI	1.07e-03	16	57	2	IPR004001
Domain	ACTINS_2	POTEE POTEI	1.21e-03	17	57	2	PS00432
Domain	Actin/actin-like_CS	POTEE POTEI	1.36e-03	18	57	2	IPR020902
Domain	ACTINS_ACT_LIKE	POTEE POTEI	1.51e-03	19	57	2	PS01132
Domain	K_chnl_dom	KCNN1 KCNN3	1.85e-03	21	57	2	IPR013099
Domain	Ion_trans_2	KCNN1 KCNN3	1.85e-03	21	57	2	PF07885
Domain	ZF_RING_1	RNF121 TRIM49 TRIM49C SIAH2 TRIM49B	1.92e-03	291	57	5	PS00518
Domain	-	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	2.40e-03	449	57	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF121 TRIM49 TRIM49C TRIM49D1 SIAH2 TRIM49B	2.68e-03	459	57	6	IPR013083
Domain	Bromodomain_CS	SMARCA2 SMARCA4	2.84e-03	26	57	2	IPR018359
Domain	Actin	POTEE POTEI	4.02e-03	31	57	2	IPR004000
Domain	Actin	POTEE POTEI	4.02e-03	31	57	2	PF00022
Domain	ACTIN	POTEE POTEI	4.02e-03	31	57	2	SM00268
Domain	Helicase_C	IFIH1 SMARCA2 SMARCA4	4.27e-03	107	57	3	PF00271
Domain	HELICc	IFIH1 SMARCA2 SMARCA4	4.27e-03	107	57	3	SM00490
Domain	SNF2_N	SMARCA2 SMARCA4	4.28e-03	32	57	2	IPR000330
Domain	SNF2_N	SMARCA2 SMARCA4	4.28e-03	32	57	2	PF00176
Domain	Helicase_C	IFIH1 SMARCA2 SMARCA4	4.39e-03	108	57	3	IPR001650
Domain	HELICASE_CTER	IFIH1 SMARCA2 SMARCA4	4.50e-03	109	57	3	PS51194
Domain	HELICASE_ATP_BIND_1	IFIH1 SMARCA2 SMARCA4	4.50e-03	109	57	3	PS51192
Domain	DEXDc	IFIH1 SMARCA2 SMARCA4	4.50e-03	109	57	3	SM00487
Domain	Helicase_ATP-bd	IFIH1 SMARCA2 SMARCA4	4.62e-03	110	57	3	IPR014001
Domain	BROMODOMAIN_1	SMARCA2 SMARCA4	5.69e-03	37	57	2	PS00633
Domain	Bromodomain	SMARCA2 SMARCA4	6.00e-03	38	57	2	PF00439
Domain	BROMODOMAIN_2	SMARCA2 SMARCA4	6.95e-03	41	57	2	PS50014
Domain	BROMO	SMARCA2 SMARCA4	7.29e-03	42	57	2	SM00297
Domain	Bromodomain	SMARCA2 SMARCA4	7.29e-03	42	57	2	IPR001487
Domain	-	SMARCA2 SMARCA4	7.29e-03	42	57	2	1.20.920.10
Pathway	REACTOME_CA2_ACTIVATED_K_CHANNELS	KCNN1 KCNN3	9.99e-05	6	37	2	MM14543
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49 TRIM49C TRIM49D1 TRIM49B	2.47e-08	19	57	4	22144910
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM49 TRIM49C TRIM49B	1.87e-06	15	57	3	19703589
Pubmed	The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.	SMARCA2 SMARCA4	2.64e-06	2	57	2	8670841
Pubmed	Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23163725
Pubmed	Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23076393
Pubmed	Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.	SMARCA2 SMARCA4	2.64e-06	2	57	2	9603422
Pubmed	The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.	SMARCA2 SMARCA4	2.64e-06	2	57	2	15576411
Pubmed	SWI/SNF gene variants and glioma risk and outcome.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23276717
Pubmed	Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.	SMARCA2 SMARCA4	2.64e-06	2	57	2	27097303
Pubmed	Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.	SMARCA2 SMARCA4	2.64e-06	2	57	2	15240517
Pubmed	Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.	SMARCA2 SMARCA4	2.64e-06	2	57	2	26564006
Pubmed	SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.	SMARCA2 SMARCA4	2.64e-06	2	57	2	33027072
Pubmed	SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.	SMARCA2 SMARCA4	2.64e-06	2	57	2	28038711
Pubmed	A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23872584
Pubmed	Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23963727
Pubmed	SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.	SMARCA2 SMARCA4	2.64e-06	2	57	2	12493776
Pubmed	Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.	SMARCA2 SMARCA4	2.64e-06	2	57	2	31375262
Pubmed	Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.	SMARCA2 SMARCA4	2.64e-06	2	57	2	23088494
Pubmed	Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.	SMARCA2 SMARCA4	2.64e-06	2	57	2	17075831
Pubmed	Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.	CYBB RYR2	2.64e-06	2	57	2	24104877
Pubmed	SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.	SMARCA2 SMARCA4	2.64e-06	2	57	2	20333683
Pubmed	SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.	SMARCA2 SMARCA4	2.64e-06	2	57	2	34812766
Pubmed	Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.	SMARCA2 SMARCA4	2.64e-06	2	57	2	32855269
Pubmed	Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.	SMARCA2 SMARCA4	2.64e-06	2	57	2	30478150
Pubmed	SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.	CYBB KCNN3	2.64e-06	2	57	2	25730848
Pubmed	Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.	SMARCA2 SMARCA4	2.64e-06	2	57	2	22721696
Pubmed	Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.	SMARCA2 SMARCA4	2.64e-06	2	57	2	18508913
Pubmed	Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.	SMARCA2 SMARCA4	2.64e-06	2	57	2	11719516
Pubmed	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.	SMARCA2 SMARCA4	2.64e-06	2	57	2	25808524
Pubmed	Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.	SMARCA2 SMARCA4	2.64e-06	2	57	2	19144648
Pubmed	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.	SMARCA2 SMARCA4	2.64e-06	2	57	2	28706277
Pubmed	[Expression of BRG1 and BRM proteins in prostatic cancer].	SMARCA2 SMARCA4	2.64e-06	2	57	2	21092585
Pubmed	High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.	SMARCA2 SMARCA4	2.64e-06	2	57	2	29391527
Pubmed	Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.	SMARCA2 SMARCA4	2.64e-06	2	57	2	37634210
Pubmed	SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.	SMARCA2 SMARCA4	2.64e-06	2	57	2	26551623
Pubmed	Small-conductance, calcium-activated potassium channels from mammalian brain.	KCNN1 KCNN3	2.64e-06	2	57	2	8781233
Pubmed	SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.	SMARCA2 SMARCA4	2.64e-06	2	57	2	19458193
Pubmed	Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.	SMARCA2 SMARCA4	2.64e-06	2	57	2	8208605
Pubmed	The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.	SMARCA2 SMARCA4	2.64e-06	2	57	2	34289068
Pubmed	SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.	SMARCA2 SMARCA4	2.64e-06	2	57	2	34518526
Pubmed	SMARCA family of genes.	SMARCA2 SMARCA4	2.64e-06	2	57	2	32312722
Pubmed	Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.	SMARCA2 SMARCA4	2.64e-06	2	57	2	26356327
Pubmed	Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.	SMARCA2 SMARCA4	2.64e-06	2	57	2	12566296
Pubmed	A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.	SMARCA2 SMARCA4	2.64e-06	2	57	2	11163203
Pubmed	Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.	SMARCA2 SMARCA4	2.64e-06	2	57	2	12620226
Pubmed	SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.	SMARCA2 SMARCA4	2.64e-06	2	57	2	31406271
Pubmed	BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.	SMARCA2 SMARCA4	2.64e-06	2	57	2	27039070
Pubmed	Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.	SMARCA2 SMARCA4	2.64e-06	2	57	2	29848589
Pubmed	Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.	SMARCA2 SMARCA4	2.64e-06	2	57	2	29273066
Pubmed	Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.	KCNN1 KCNN3	7.91e-06	3	57	2	15234350
Pubmed	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.	SMARCA2 SMARCA4	7.91e-06	3	57	2	28292935
Pubmed	Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.	SMARCA2 SMARCA4	7.91e-06	3	57	2	36464671
Pubmed	Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle.	KCNN1 KCNN3	7.91e-06	3	57	2	11557517
Pubmed	Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain.	KCNN1 KCNN3	7.91e-06	3	57	2	11146124
Pubmed	DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.	SMARCA2 SMARCA4	7.91e-06	3	57	2	30287812
Pubmed	Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.	KCNN1 KCNN3	7.91e-06	3	57	2	16055520
Pubmed	Small-conductance calcium-activated K(+) channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration.	KCNN1 KCNN3	7.91e-06	3	57	2	22416006
Pubmed	Partial apamin sensitivity of human small conductance Ca2+-activated K+ channels stably expressed in Chinese hamster ovary cells.	KCNN1 KCNN3	7.91e-06	3	57	2	12382077
Pubmed	Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.	KCNN1 KCNN3	7.91e-06	3	57	2	15190101
Pubmed	The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes.	SMARCA2 SMARCA4	7.91e-06	3	57	2	17938176
Pubmed	Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.	SMARCA2 SMARCA4	7.91e-06	3	57	2	22740088
Pubmed	Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.	KCNN1 KCNN3	7.91e-06	3	57	2	20689065
Pubmed	BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.	SMARCA2 SMARCA4	7.91e-06	3	57	2	15034933
Pubmed	TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.	SMARCA2 SMARCA4	7.91e-06	3	57	2	15075294
Pubmed	Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.	KCNN1 KCNN3	7.91e-06	3	57	2	24434522
Pubmed	A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.	SMARCA2 SMARCA4	7.91e-06	3	57	2	12044884
Pubmed	SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.	SMARCA2 SMARCA4	7.91e-06	3	57	2	21518954
Pubmed	Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.	SMARCA2 SMARCA4	7.91e-06	3	57	2	19784067
Pubmed	Characterization of mammary tumors from Brg1 heterozygous mice.	SMARCA2 SMARCA4	7.91e-06	3	57	2	17637742
Pubmed	BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.	SMARCA2 SMARCA4	7.91e-06	3	57	2	20571081
Pubmed	Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.	SMARCA2 SMARCA4	7.91e-06	3	57	2	14603256
Pubmed	SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†.	SMARCA2 SMARCA4	7.91e-06	3	57	2	36440965
Pubmed	Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2.	SMARCA2 SMARCA4	7.91e-06	3	57	2	9099865
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	SMARCA2 SMARCA4 POGZ ZNF362	1.08e-05	83	57	4	28794006
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF280D SMARCA2 SMARCA4 POGZ	1.08e-05	83	57	4	20562864
Pubmed	Dual role of NRSF/REST in activation and repression of the glucocorticoid response.	SMARCA2 SMARCA4	1.58e-05	4	57	2	17984088
Pubmed	Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.	SMARCA2 SMARCA4	1.58e-05	4	57	2	31906887
Pubmed	Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.	SMARCA2 SMARCA4	1.58e-05	4	57	2	19805516
Pubmed	SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice.	SMARCA2 SMARCA4	1.58e-05	4	57	2	25904594
Pubmed	Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.	KCNN1 KCNN3	1.58e-05	4	57	2	29737974
Pubmed	BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development.	SMARCA2 SMARCA4	1.58e-05	4	57	2	11231080
Pubmed	BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.	SMARCA2 SMARCA4	1.58e-05	4	57	2	15141164
Pubmed	BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.	SMARCA2 SMARCA4	1.58e-05	4	57	2	23897427
Pubmed	Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.	SMARCA2 SMARCA4	1.58e-05	4	57	2	19781646
Pubmed	Brahma safeguards canalization of cardiac mesoderm differentiation.	SMARCA2 SMARCA4	1.58e-05	4	57	2	35082446
Pubmed	Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.	KCNN1 KCNN3	1.58e-05	4	57	2	12882916
Pubmed	BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.	SMARCA2 SMARCA4	1.58e-05	4	57	2	28232072
Pubmed	The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes.	SMARCA2 SMARCA4	1.58e-05	4	57	2	33481850
Pubmed	Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.	SMARCA2 SMARCA4	1.58e-05	4	57	2	9744861
Pubmed	Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.	SMARCA2 SMARCA4	1.58e-05	4	57	2	24421395
Pubmed	Mammalian chromatin remodeling complex SWI/SNF is essential for enhanced expression of the albumin gene during liver development.	SMARCA2 SMARCA4	1.58e-05	4	57	2	16452305
Pubmed	Control of B cell development by the histone H2A deubiquitinase MYSM1.	SMARCA2 SMARCA4	1.58e-05	4	57	2	22169041
Pubmed	Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.	POTEE SMARCA4 SPAG9	2.00e-05	32	57	3	31815296
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF644 SMARCA2 SMARCA4 POGZ	2.54e-05	103	57	4	32744500
Pubmed	Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.	SMARCA2 SMARCA4	2.63e-05	5	57	2	18487222
Pubmed	Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells.	KCNN1 KCNN3	2.63e-05	5	57	2	28274924
Pubmed	Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).	SMARCA2 SMARCA4	2.63e-05	5	57	2	9843504
Pubmed	The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.	SMARCA2 SMARCA4	2.63e-05	5	57	2	19342595
Pubmed	Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.	SMARCA2 SMARCA4	2.63e-05	5	57	2	12200431
Pubmed	Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.	SMARCA2 SMARCA4	2.63e-05	5	57	2	25801033
Cytoband	11q14.3	TRIM49C TRIM49D1	7.33e-04	32	57	2	11q14.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q14	TRIM49 TRIM49C TRIM49D1	9.84e-04	156	57	3	chr11q14
Cytoband	2q21.1	POTEE POTEI	2.39e-03	58	57	2	2q21.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ATMIN BNC1 ZNF366 ZNF652 ZBTB22 ZBTB47 ZNF362 ZNF865 CASZ1	1.70e-05	718	39	9	28
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM49 TRIM49C TRIM49D1 TRIM49B	5.11e-05	95	39	4	59
GeneFamily	Potassium calcium-activated channels	KCNN1 KCNN3	6.76e-05	6	39	2	255
GeneFamily	Ring finger proteins	RNF121 TRIM49 TRIM49C TRIM49D1 TRIM49B	2.96e-04	275	39	5	58
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEE POTEI	3.48e-04	13	39	2	685
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MSANTD3 CDC5L	5.83e-03	53	39	2	532
Disease	female reproductive system disease	BNC1 MICA GREB1	8.92e-06	23	52	3	EFO_0009549
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	SMARCA2 SMARCA4	3.04e-05	5	52	2	C3281201
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCA2 SMARCA4	1.09e-04	9	52	2	DOID:0050340 (implicated_via_orthology)
Disease	neutrophil count	IFIH1 CEPT1 ZNF366 KCNN3 PAM MICA POGZ GRIN3B CASZ1 CREB5	1.29e-04	1382	52	10	EFO_0004833
Disease	Coffin-Siris syndrome	SMARCA2 SMARCA4	2.35e-04	13	52	2	C0265338
Disease	intellectual disability (implicated_via_orthology)	ZNF280A ZNF280D POGZ	3.19e-04	75	52	3	DOID:1059 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	SMARCA2 SMARCA4 CDC5L RYR2	3.91e-04	195	52	4	DOID:1574 (implicated_via_orthology)
Disease	neutrophil percentage of granulocytes	TLCD3B ZNF652 MICA CREB5	7.03e-04	228	52	4	EFO_0007994
Disease	response to antineoplastic agent	SMARCA2 MICA RYR2	7.19e-04	99	52	3	GO_0097327
Disease	eosinophil percentage of granulocytes	TLCD3B ZNF652 MICA CREB5	7.74e-04	234	52	4	EFO_0007996
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	SMARCA4 MICA MCUB	8.06e-04	103	52	3	EFO_0008595, EFO_0020944
Disease	coronary artery disease, factor VII measurement	PRDM8 ZNF652 SMARCA4	1.00e-03	111	52	3	EFO_0001645, EFO_0004619
Disease	factor VIII measurement, coronary artery disease	PRDM8 ZNF652 SMARCA4	1.05e-03	113	52	3	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	PRDM8 ZNF652 SMARCA4	1.11e-03	115	52	3	EFO_0001645, EFO_0004694
Disease	von Willebrand factor measurement, coronary artery disease	PRDM8 ZNF652 SMARCA4	1.19e-03	118	52	3	EFO_0001645, EFO_0004629
Disease	angina pectoris	PRDM8 ZNF652 SMARCA4	1.41e-03	125	52	3	EFO_0003913
Disease	mean arterial pressure, unipolar depression	PRDM8 CASZ1	1.46e-03	32	52	2	EFO_0003761, EFO_0006340
Disease	unipolar depression, systolic blood pressure	PRDM8 CASZ1	1.65e-03	34	52	2	EFO_0003761, EFO_0006335
Disease	Kartagener Syndrome	SPAG1 DNAH9	1.75e-03	35	52	2	C0022521
Disease	Polynesian Bronchiectasis	SPAG1 DNAH9	1.75e-03	35	52	2	C4317124
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	SPAG1 DNAH9	1.75e-03	35	52	2	C4551906
Disease	parental longevity	ZNF704 ZBTB22 SMARCA2 SMARCA4 CREB5	1.75e-03	494	52	5	EFO_0007796

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLKNIKFMNHMKHHL	ZNF280A	306	P59817
FMNHMKHHLELEKQS	ZNF280D	336	Q6N043
KKEMITMLHYDLLHH	CDC5L	576	Q99459
FLLKHQMTSHARKHM	CASZ1	1311	Q86V15
KIHHKNMHVKEMHTC	BNC1	736	Q01954
KHRHMFVKQVDMDHV	ABHD3	281	Q8WU67
VKSDMVMMHEHHKET	PAM	351	P19021
VMMHEHHKETEYKDK	PAM	356	P19021
MIHNYMEHLERTKLH	SPAG9	166	O60271
EDAMKTKTHYHAMHA	MICA	171	Q29983
SHLHHMLFELFKNAM	PDK4	246	Q16654
DHLMIHRHKHEMTLK	CREB5	31	Q02930
EHTAEMEHMKSLVHR	MCUB	156	Q9NWR8
KHIMQHIEAAPDIMH	GREB1	1676	Q4ZG55
KGSKDVVDHMTIHMD	KIAA1109	2671	Q2LD37
LTKAEKHVHNFMMDT	KCNN1	371	Q92952
LELTKAEKHVHNFMM	KCNN3	546	Q9UGI6
MKKHHEQEMEKHHVP	KRT23	206	Q9C075
GALKKMHEEEHHQQM	MSANTD3	191	Q96H12
AAVVHHMRKLHMNLH	CAMK1G	311	Q96NX5
FMAIEEMKKHGSTHV	POTEE	536	Q6S8J3
LVKQHFMKMHAEKKH	ATMIN	151	O43313
VAHMTKSEMHLHDTA	CEPT1	336	Q9Y6K0
DGEHFAMEMHIVHEK	CA4	131	P22748
AMEMHIVHEKEKGTS	CA4	136	P22748
VKHSMEHVSMACVHL	CCNL2	116	Q96S94
HVIEKMHHVNMTPEF	IFIH1	921	Q9BYX4
VAMHVAHQQHIEKKM	GJB1	91	P08034
HKMVAWMIALHSAIH	CYBB	101	P04839
NHVLGHMKATVRHEM	DNAH9	1681	Q9NYC9
SIQRKAIMHHEGHMD	RYR2	386	Q92736
IKKSFPDMHAHMRRH	GRIN3B	706	O60391
MPAFHHEEEKHNLEM	TRIM49	186	P0CI25
KYMIVDEGHRMKNHH	SMARCA2	846	P51531
QMLDKKMSLCHAHHA	SPATA31A6	1211	Q5VVP1
AKIRHHIDDLVMHMS	LAMA1	1846	P25391
NIRFMNHMKHHVELD	POGZ	506	Q7Z3K3
MTSDLVYHMRSHHKK	PRDM8	636	Q9NQV8
KYMIVDEGHRMKNHH	SMARCA4	876	P51532
LEAVMSHLMHAHKSI	SIAH2	181	O43255
MMVFLHKHELLTMYH	SLC40A1	111	Q9NP59
FMAIEEMKKHGSTHV	POTEI	536	P0CG38
MIKITHVHVHMRYDA	PROZ	241	P22891
DSHLVVKKHQAMEAM	ARAP1	1251	Q96P48
EELNKHSHMIAMIHS	CIP2A	876	Q8TCG1
LFHVMSHKEVHMAEK	ZNF865	681	P0CJ78
MPAFHHEEEKHNLEM	TRIM49C	186	P0CI26
DKMHFHETETFPAMK	SPAG1	111	Q07617
HAKHRGHEAMHAEMV	RNF121	41	Q9H920
KSMETHIMHTFKEDF	RFK	76	Q969G6
TMAHVRKHMVAHTKD	ZBTB47	531	Q9UFB7
KKMSHQHVFSLAMEE	ZNF704	16	Q6ZNC4
EKKHLHRHMMYHLDG	ZNF644	421	Q9H582
TSHLKRHMMQHSEVK	ZNF366	321	Q8N895
LHKEFLMVLHHAAMV	TLCD3B	126	Q71RH2
MPAFHHEEEKHNLEM	TRIM49D1	186	C9J1S8
LMKHMSKHTVVEHLV	ZNF362	386	Q5T0B9
MPAFHHEEEKHNLEM	TRIM49B	186	A6NDI0
MAHVRKHMVAHTKDM	ZNF652	341	Q9Y2D9
KFKMKHHLTEHMKTH	ZBTB22	521	O15209