Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainAnk_2

ESPN ANK2 ANKRD17 SOWAHC HECTD1

7.89e-04215635PF12796
DomainAnk

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.03e-03228635PF00023
DomainBbox_C

TRIM33 TRIM37

1.14e-0315632IPR003649
DomainBBC

TRIM33 TRIM37

1.14e-0315632SM00502
Domain-

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.49e-032486351.25.40.20
DomainANK

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.57e-03251635SM00248
DomainANK_REPEAT

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.63e-03253635PS50088
DomainBBOX

TRIM33 TRIM54 TRIM37

1.64e-0369633SM00336
DomainAnkyrin_rpt-contain_dom

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.65e-03254635IPR020683
DomainANK_REP_REGION

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.65e-03254635PS50297
DomainRUN

RUSC1 RUNDC1

1.65e-0318632SM00593
DomainProtein_kinase_ATP_BS

LIMK1 CAMKK2 PAK5 MARK4 PRKCI FGR

1.72e-03379636IPR017441
Domain-

TRIM33 TRIM54 TRIM37

1.78e-03716334.10.45.10
DomainRUN

RUSC1 RUNDC1

1.85e-0319632PS50826
DomainRUN

RUSC1 RUNDC1

1.85e-0319632PF02759
DomainRun_dom

RUSC1 RUNDC1

1.85e-0319632IPR004012
Domainzf-B_box

TRIM33 TRIM54 TRIM37

1.85e-0372633PF00643
DomainAnkyrin_rpt

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.89e-03262635IPR002110
DomainZF_BBOX

TRIM33 TRIM54 TRIM37

2.50e-0380633PS50119
DomainZnf_B-box

TRIM33 TRIM54 TRIM37

2.59e-0381633IPR000315
DomainHormR

GLP1R ADGRL3

3.20e-0325632SM00008
DomainHRM

GLP1R ADGRL3

4.00e-0328632PF02793
DomainPROTEIN_KINASE_ATP

LIMK1 CAMKK2 PAK5 MARK4 PRKCI FGR

4.44e-03459636PS00107
DomainZnf-RING_LisH

TRIM33 TRIM54

5.86e-0334632IPR027370
Domainzf-RING_UBOX

TRIM33 TRIM54

5.86e-0334632PF13445
DomainGPCR_2_secretin-like_CS

GLP1R ADGRL3

5.86e-0334632IPR017983
DomainProt_kinase_dom

LIMK1 CAMKK2 PAK5 MARK4 PRKCI FGR

6.02e-03489636IPR000719
DomainPROTEIN_KINASE_DOM

LIMK1 CAMKK2 PAK5 MARK4 PRKCI FGR

6.25e-03493636PS50011
DomainSer/Thr_kinase_AS

LIMK1 CAMKK2 PAK5 MARK4 PRKCI

7.05e-03357635IPR008271
DomainKH_1

ANKRD17 PCBP4

7.28e-0338632PF00013
DomainPROTEIN_KINASE_ST

LIMK1 CAMKK2 PAK5 MARK4 PRKCI

7.46e-03362635PS00108
Domain-

ANKRD17 PCBP4

7.66e-03396323.30.1370.10
DomainKH

ANKRD17 PCBP4

8.04e-0340632SM00322
DomainG_PROTEIN_RECEP_F2_1

GLP1R ADGRL3

8.04e-0340632PS00649
DomainGPCR_2_extracellular_dom

GLP1R ADGRL3

8.04e-0340632IPR001879
DomainKH_dom

ANKRD17 PCBP4

8.04e-0340632IPR004087
DomainG_PROTEIN_RECEP_F2_3

GLP1R ADGRL3

8.04e-0340632PS50227
DomainKH_TYPE_1

ANKRD17 PCBP4

8.84e-0342632PS50084
DomainPkinase

LIMK1 CAMKK2 PAK5 MARK4 PRKCI

9.19e-03381635PF00069
DomainKH_dom_type_1

ANKRD17 PCBP4

9.67e-0344632IPR004088
DomainKinase-like_dom

LIMK1 CAMKK2 PAK5 MARK4 PRKCI FGR

9.75e-03542636IPR011009
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

LIMK1 IRS4 AHNAK PAK5 MARK4 NEURL1 LARP1 ANKRD17 PRKCI PUM1 HECTD1 ITPKB

1.00e-07861681236931259
Pubmed

Atypical PKC phosphorylates microtubule affinity-regulating kinase 4 in vitro.

MARK4 PRKCI

3.77e-06268226346160
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

IRS4 ANAPC1 AHNAK ANKRD17 CDC6 PRRC2B

8.14e-0624268634011540
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

IRS4 ANAPC1 LARP1 PRKCI PUM1 HECTD1 TRIM37

2.69e-0544668724255178
Pubmed

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

SCHIP1 ANK2

3.75e-05568225950943
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IRS4 ANAPC1 AHNAK LARP1 ANKRD17 PUM1 HECTD1 PRRC2B

4.06e-0565368822586326
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TRIM33 PSME3IP1 ZFHX4 ANAPC1 IARS1 LARP1 RITA1 ANKRD17 PUM1

4.31e-0585768925609649
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ANAPC1 AHNAK LARP1 ANKRD17 HECTD1

4.87e-0520268533005030
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

VAC14 SZT2 AHNAK MARK4 USP40 FAM110A PUM1 HECTD1 BAHD1 PRRC2B

5.50e-051105681035748872
Pubmed

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.

ANAPC1 CDC6

7.86e-05768221768287
Pubmed

Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.

ANKRD17 CDC6

7.86e-05768219150984
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TRIM33 CAMKK2 NYAP2 SZT2 LARP1 ANKRD17 BAHD1

7.87e-0552968714621295
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CAMKK2 MARK4 PUM1 CSMD3 ADGRL3 PRRC2B

1.47e-0440768612693553
Pubmed

Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.

IRS4 AHNAK LARP1

1.65e-045468325631074
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

IRS4 ZFHX4 ANAPC1 AHNAK RUSC1 ANKRD17

1.70e-0441868634709266
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

ESPN TRIM33 GJB3 ATXN7L2 SZT2 ZBTB8B FGR PUM1 ITPKB

1.75e-04103168916710414
Pubmed

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase.

HECTD1 TRIM37

2.45e-041268234611473
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

IRS4 IARS1 LARP1 ANKRD17 PUM1 HECTD1 TRIM37

2.51e-0463968723443559
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TRIM33 ATXN7L2 ZFHX4 ANAPC1 MARK4 NEURL1 ANKRD17 SOWAHC PRRC2B

3.15e-04111668931753913
Pubmed

Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.

ANK2 AHNAK

4.44e-041668221745462
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

IRS4 ANAPC1 PRKCI PUM1

4.55e-0418268432239614
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

PSME3IP1 IRS4 ANK2 PDLIM3 AHNAK LARP1 ANKRD17 PRRC2B

4.67e-0493468833916271
Pubmed

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

TRIM33 ANAPC1

5.03e-041768223160376
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

ANAPC1 IARS1 AHNAK LARP1 ANKRD17 PUM1 PRRC2B

5.31e-0472468736232890
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

TRIM33 ANK2 RUSC1 PRKCI FAM110A PUM1 TRIM37 PRRC2B CREBZF

5.82e-04121568915146197
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

TRIM33 IRS4 IARS1 ANKRD17 PUM1 HECTD1

6.23e-0453468635032548
Pubmed

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.

LIMK1 LARP1 PRKCI

6.74e-048768317979178
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

LIMK1 CAMKK2 PRKCI FGR TRIM37

8.18e-0437268522939624
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

CAMKK2 LARP1 ADGRL3

1.04e-031016839872452
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PSME3IP1 SZT2 ANAPC1 ANKRD17 GMPR NHLRC2 HECTD1 RUNDC1 BAHD1

1.09e-03132768932694731
Pubmed

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

PSME3IP1 KDM4D LIMK1 FANCM

1.09e-0323068429513927
Pubmed

A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.

AHNAK ANKRD17

1.10e-032568235211260
Pubmed

Placentation defects are highly prevalent in embryonic lethal mouse mutants.

NHLRC2 RUNDC1 PRRC2B

1.10e-0310368329539633
Pubmed

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.

IRS4 PAK5 LARP1 PRRC2B

1.20e-0323668436339263
Pubmed

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.

AHNAK ATP2C2

1.28e-032768223144326
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

LARP1 ANKRD17 PUM1 PRRC2B

1.50e-0325168428077445
Pubmed

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.

NYAP2 ANAPC1

1.58e-033068227568566
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

NEURL1 TRIM54 TRIM37

1.62e-0311868319690564
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

LARP1 PUM1 PCBP4 PRRC2B

1.66e-0325868437794589
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

IRS4 ANAPC1 LARP1 ANKRD17 HECTD1

1.72e-0344068534244565
Pubmed

Next-generation sequencing to generate interactome datasets.

RUSC1 RITA1 PRKCI FAM110A BAHD1 PRRC2B ACSL5 ITPKB

1.75e-03114768821516116
Pubmed

Human transcription factor protein interaction networks.

TRIM33 IRS4 ATXN7L2 ZFHX4 IARS1 LARP1 ANKRD17 PUM1 PRRC2B

1.81e-03142968935140242
Pubmed

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

IRS4 ANK2 AHNAK LARP1 ANKRD17

1.88e-0344968531732153
Pubmed

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

DDX12P HECTD1

1.91e-033368215755804
CytobandXq22.3

IRS4 TBC1D8B

1.11e-0333682Xq22.3
CytobandEnsembl 112 genes in cytogenetic band chr1p35

ZBTB8B FGR PUM1

1.13e-03137683chr1p35
GeneFamilyAnkyrin repeat domain containing

ESPN ANK2 ANKRD17 SOWAHC HECTD1

1.85e-04242405403
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM33 TRIM54 TRIM37

1.21e-039540359
GeneFamilyRing finger proteins

TRIM33 NEURL1 TRIM54 TRIM37

3.11e-0327540458
GeneFamilyPDZ domain containing

LIMK1 PDLIM3 AHNAK

4.58e-031524031220
GeneFamilyBasic leucine zipper proteins

NRL CREBZF

5.26e-0349402506
GeneFamilyLIM domain containing

LIMK1 PDLIM3

7.54e-03594021218
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ESPN IGLV1-47 IGLV1-44 ATP2C2 NEURL1

6.07e-06169685a2f521f68681c0358448fa68329df764659ff52c
ToppCellproximal-Epithelial-Ionocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN IRS4 DDX12P PAK5 NEURL1

1.27e-05197685f65c35761da7c168d5c6e4d7edf5dafa26652fe4
ToppCellproximal-Epithelial-Ionocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN IRS4 DDX12P PAK5 NEURL1

1.27e-05197685e5d5accefaacea5ed2e22f906f5bcbc75083f287
ToppCellproximal-3-Epithelial-Ionocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ESPN IRS4 DDX12P PAK5 NEURL1

1.27e-05197685288492fc67d8e81349d38e82caf1f1890276b299
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

TRIM33 AHNAK NHLRC2 CSMD3 SPINK5

1.37e-05200685fe772d98c461c973dfc082e1fc50117c27ced804
DiseaseColorectal Carcinoma

IRS4 ANK2 NEURL1 MCF2L2 ZBTB8B CSMD3 IL6ST ACSL5

1.35e-04702648C0009402
DiseaseCannabis use, age at onset

ATP2C2 LARP1

7.73e-0419642EFO_0004847, EFO_0007585
Diseaseperipheral neuropathy, response to docetaxel trihydrate

VAC14 NYAP2

7.73e-0419642EFO_0003100, GO_1902519
DiseaseDeaf Mutism

ESPN GJB3

8.58e-0420642C4082305
DiseaseDeafness, Acquired

ESPN GJB3

8.58e-0420642C0751068
DiseaseHearing Loss, Extreme

ESPN GJB3

8.58e-0420642C0086395
DiseaseComplete Hearing Loss

ESPN GJB3

8.58e-0420642C0581883
DiseasePrelingual Deafness

ESPN GJB3

8.58e-0420642C0011052
DiseaseBilateral Deafness

ESPN GJB3

8.58e-0420642C3665473
Diseasecognitive function measurement

VAC14 NYAP2 ATXN7L2 PDLIM3 NRL SZT2 MCF2L2 CSMD3 TRIM37 ACSL5

9.83e-0414346410EFO_0008354
DiseaseAdenocarcinoma of large intestine

CAMKK2 PAK5 MARK4

1.20e-0396643C1319315
DiseaseDeafness

ESPN GJB3

1.35e-0325642C0011053
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

MARK4 ANKRD17

1.46e-0326642OBA_2045194

Protein segments in the cluster

PeptideGeneStartEntry
PCGSRSTGSEGTVLS

CSMD3

1761

Q7Z407
CSGKSTESSIGSGKT

ADGRL3

1121

Q9HAR2
RLGSPSGKTGTCRIS

AHNAK

556

Q09666
EGTSNSLSTCTKSGP

ANKRD17

1681

O75179
GGGRCSIPSLSSSST

C3orf36

121

Q3SXR2
CSKTDSPLTGGGDLT

ATP2C2

226

O75185
CRAPGSTKTSSREKG

ATXN7L2

136

Q5T6C5
TPLVCKSGSLFGSSR

ANAPC1

221

Q9H1A4
SSCRGGTSPTKESKE

ANK2

3451

Q01484
PSRTAGTSGCSKESL

PAK5

236

Q9P286
TACLETAKSTSGGTP

PCBP4

306

P57723
GGGEGRKRCPSQSSS

LARP1

1046

Q6PKG0
IPSGAGRTKAFSTCG

OR11H6

246

Q8NGC7
KEGLRPGDTTSTFCG

PRKCI

401

P41743
EARSLSSGKTGCIPS

FGR

116

P09769
LKCPTSSLSSGATAG

GLP1R

436

P43220
RSTGKCEESSTPGTT

SPINK5

1041

Q9NQ38
PGCGQRRSSSSTGST

ESPN

626

B1AK53
ISRSSGTPGCSSGTE

FANCM

16

Q8IYD8
DPASSTGGIKGCSSR

MCF2L2

996

Q86YR7
GTPGQRVTISCSGSS

IGLV1-47

31

P01700
PGSSEGGCSRRSSVT

FAM110A

241

Q9BQ89
KARCDRLTSSGPGSG

NRL

216

P54845
PSTVRLISCSGDTGS

GANC

106

Q8TET4
GTPGQRVTISCSGSS

IGLV1-44

31

P01699
AKRPLLAGTTCTASG

KDM4D

471

Q6B0I6
SRSGSCSGQGRDSSK

KRT24

481

Q2M2I5
PSSCTSGGSLLGDKT

MMAA

181

Q8IVH4
PKVSCKLGRSASTSG

NYAP2

611

Q9P242
DLPSGSKLTEGVSSC

NHLRC2

621

Q8NBF2
LSSSPGDSCLRKGGF

PUM1

226

Q14671
TVSGPSSACKPGRST

HECTD1

246

Q9ULT8
SSACKPGRSTTGAPS

HECTD1

251

Q9ULT8
SGIGGSSCMSSSRPS

IL6ST

726

P40189
GCSGSLSLRGPASFK

DDX12P

6

Q92771
TRDACGPTSSDKGGV

DNAAF8

216

Q8IYS4
PPSGSKSGLRTGSSC

BAHD1

541

Q8TBE0
SVICFTSGTTGDPKG

ACSL5

256

Q9ULC5
SGAPGTGKTACLSRI

CDC6

201

Q99741
RLPGRKASCSTAGSG

MARK4

451

Q96L34
KASCSTAGSGSRGLP

MARK4

456

Q96L34
GGRGSSSSESQKPCE

CAMKK2

21

Q96RR4
GPGSVCTTRTKTGVG

GMPR

181

P36959
DKPRGGCSPSSSASR

GJB3

221

O75712
SSGTPTALIGTGSSC

IRS4

36

O14654
KTGNGCSRTGSSRTP

RUNDC1

306

Q96C34
CSRTGSSRTPPGNSK

RUNDC1

311

Q96C34
TGGKESRGPCSGTLV

RUSC1

46

Q9BVN2
ILGTEGRGSFSCPKT

SZT2

2951

Q5T011
GRGSFSCPKTKTDGS

SZT2

2956

Q5T011
LNTSGTKGLECSPST

VAC14

506

Q08AM6
RGSCGSSGRTAEKTS

TRIM33

751

Q9UPN9
SKGDCQTLSEGSPGS

TRIM37

786

O94972
KSGDLSTRSPTTGLC

TREML2

231

Q5T2D2
AGPSSDTCESGAGSK

SPATA31C2

686

B4DYI2
SECKSSSSPGGSLDL

SCHIP1

56

P0DPB3
DSGRKGGPSLCSSQV

ITPKB

216

P27987
SCKSLGNTSLSGPSI

PSME3IP1

186

Q9GZU8
IDCGSGRSTPSSVST

PDLIM3

141

Q53GG5
LKRSVCPGGSSPGSS

SOWAHC

216

Q53LP3
SLSGKTLCVTAGSAP

IARS1

1146

P41252
AKGSCETTPSRGSTP

RITA1

76

Q96K30
GSTTVSSGGRFRCPS

TRIM54

66

Q9BYV2
PKCDTVLGSSRSLGG

ZFHX4

616

Q86UP3
LLSTCSSGPLGSSAG

NEURL1

481

O76050
PTSSAKGFSGTVCGS

TBC1D8B

1036

Q0IIM8
TVCGSGGPSEEKTGS

TBC1D8B

1046

Q0IIM8
GGCSSSSDSGSAEKR

CREBZF

171

Q9NS37
CSGDKSGTVGRRSPE

PRRC2B

1346

Q5JSZ5
CARSPGSAQSLGKGS

WNT8A

336

Q9H1J5
GSSLGLCLGKAPSSS

USP40

826

Q9NVE5
PSSGREGTSCGTKSL

ZBTB8B

161

Q8NAP8
EGTSCGTKSLVSSPA

ZBTB8B

166

Q8NAP8
SCSIDRSPGAGSLGS

LIMK1

296

P53667