Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein kinase activity

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

8.35e-05600367GO:0004672
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 CDK7

1.41e-0410362GO:0008353
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

2.35e-04709367GO:0016773
GeneOntologyMolecularFunctionkinase activity

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

3.69e-04764367GO:0016301
GeneOntologyMolecularFunctionprotein serine kinase activity

MAP3K9 CDC42BPB CDK12 SPEG CDK7

4.58e-04363365GO:0106310
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNT6 GALNT16

5.88e-0420362GO:0004653
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

CDK12 CDK7

7.81e-0423362GO:0140994
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

MAP3K9 CDC42BPB CDK12 SPEG CDK7

1.16e-03446365GO:0004674
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

1.25e-03938367GO:0016772
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK12 CDK7

1.33e-0330362GO:0097472
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK12 CDK7

1.33e-0330362GO:0004693
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNT6 GALNT16

1.81e-0335362GO:0008376
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

PRMT2 KMT2D

2.85e-0344362GO:0140938
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

WDR81 UBQLN3

5.07e-0359362GO:0031593
GeneOntologyMolecularFunctionmodification-dependent protein binding

WDR81 DPF2 UBQLN3

6.01e-03206363GO:0140030
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

MUSK EPHA5

6.12e-0365362GO:0004714
GeneOntologyMolecularFunctionhistone methyltransferase activity

PRMT2 KMT2D

7.26e-0371362GO:0042054
GeneOntologyCellularComponentnBAF complex

DPF1 DPF2

3.41e-0416362GO:0071565
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK12 CDK7

4.34e-0418362GO:0019908
GeneOntologyCellularComponentcarboxy-terminal domain protein kinase complex

CDK12 CDK7

7.77e-0424362GO:0032806
DomainProtein_kinase_ATP_BS

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

6.74e-06379367IPR017441
DomainKinase-like_dom

WDR81 MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

7.06e-06542368IPR011009
DomainRequiem/DPF_N_dom

DPF1 DPF2

1.08e-053362IPR025750
DomainRequiem_N

DPF1 DPF2

1.08e-053362PF14051
Domainfn3

MYOM2 ROBO3 CSF2RB SPEG EPHA5

1.40e-05162365PF00041
DomainPROTEIN_KINASE_ATP

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

2.33e-05459367PS00107
DomainFN3

MYOM2 ROBO3 CSF2RB SPEG EPHA5

2.65e-05185365SM00060
DomainProt_kinase_dom

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

3.49e-05489367IPR000719
DomainPROTEIN_KINASE_DOM

MAP3K9 CDC42BPB CDK12 MUSK SPEG EPHA5 CDK7

3.68e-05493367PS50011
DomainFN3

MYOM2 ROBO3 CSF2RB SPEG EPHA5

3.76e-05199365PS50853
DomainFN3_dom

MYOM2 ROBO3 CSF2RB SPEG EPHA5

4.75e-05209365IPR003961
DomainBeach

WDR81 NBEAL2

1.29e-049362PF02138
Domain-

WDR81 NBEAL2

1.29e-0493621.10.1540.10
DomainBEACH_dom

WDR81 NBEAL2

1.29e-049362IPR000409
DomainBeach

WDR81 NBEAL2

1.29e-049362SM01026
DomainBEACH

WDR81 NBEAL2

1.29e-049362PS50197
DomainPHD

DPF1 KMT2D DPF2

4.04e-0475363PF00628
DomainZnf_PHD-finger

DPF1 KMT2D DPF2

4.70e-0479363IPR019787
DomainIg_I-set

MYOM2 ROBO3 MUSK SPEG

4.74e-04190364IPR013098
DomainI-set

MYOM2 ROBO3 MUSK SPEG

4.74e-04190364PF07679
DomainSer/Thr_kinase_AS

MAP3K9 CDC42BPB CDK12 SPEG CDK7

5.75e-04357365IPR008271
DomainS_TKc

MAP3K9 CDC42BPB CDK12 SPEG CDK7

5.89e-04359365SM00220
DomainPROTEIN_KINASE_ST

MAP3K9 CDC42BPB CDK12 SPEG CDK7

6.12e-04362365PS00108
DomainTyrKc

MAP3K9 MUSK EPHA5

6.45e-0488363SM00219
DomainTyr_kinase_cat_dom

MAP3K9 MUSK EPHA5

6.45e-0488363IPR020635
DomainPHD

DPF1 KMT2D DPF2

6.67e-0489363SM00249
DomainZnf_PHD

DPF1 KMT2D DPF2

7.11e-0491363IPR001965
DomainDAG/PE-bd

RASGRP4 CDC42BPB

7.41e-0421362IPR020454
DomainPkinase

MAP3K9 CDC42BPB CDK12 SPEG CDK7

7.71e-04381365PF00069
DomainZF_PHD_2

DPF1 KMT2D DPF2

8.06e-0495363PS50016
DomainZF_PHD_1

DPF1 KMT2D DPF2

8.31e-0496363PS01359
DomainIGc2

MYOM2 ROBO3 MUSK SPEG

1.05e-03235364SM00408
DomainIg_sub2

MYOM2 ROBO3 MUSK SPEG

1.05e-03235364IPR003598
DomainRicin_B_lectin

GALNT6 GALNT16

1.05e-0325362PF00652
DomainRICIN

GALNT6 GALNT16

1.32e-0328362SM00458
DomainRICIN_B_LECTIN

GALNT6 GALNT16

1.32e-0328362PS50231
DomainGlyco_trans_2-like

GALNT6 GALNT16

1.52e-0330362IPR001173
DomainRicin_B_lectin

GALNT6 GALNT16

1.52e-0330362IPR000772
DomainGlycos_transf_2

GALNT6 GALNT16

1.52e-0330362PF00535
Domain-

MYOM2 ROBO3 CSF2RB MUSK SPEG EPHA5

1.53e-036633662.60.40.10
DomainIg-like_fold

MYOM2 ROBO3 CSF2RB MUSK SPEG EPHA5

2.11e-03706366IPR013783
DomainSer-Thr/Tyr_kinase_cat_dom

MAP3K9 MUSK EPHA5

2.36e-03138363IPR001245
DomainZnf_FYVE_PHD

DPF1 KMT2D DPF2

2.82e-03147363IPR011011
DomainCCP

IL15RA SEZ6L2

4.85e-0354362SM00032
DomainSUSHI

IL15RA SEZ6L2

5.21e-0356362PS50923
DomainC1_1

RASGRP4 CDC42BPB

5.39e-0357362PF00130
DomainSushi_SCR_CCP_dom

IL15RA SEZ6L2

5.39e-0357362IPR000436
DomainZF_DAG_PE_1

RASGRP4 CDC42BPB

6.76e-0364362PS00479
DomainZF_DAG_PE_2

RASGRP4 CDC42BPB

6.76e-0364362PS50081
DomainC1

RASGRP4 CDC42BPB

6.96e-0365362SM00109
DomainPE/DAG-bd

RASGRP4 CDC42BPB

7.17e-0366362IPR002219
DomainSH3

MAP3K9 PRMT2 ARHGEF4

8.22e-03216363PS50002
DomainSH3

MAP3K9 PRMT2 ARHGEF4

8.22e-03216363SM00326
DomainIG

MYOM2 ROBO3 MUSK SPEG

8.48e-03421364SM00409
DomainIg_sub

MYOM2 ROBO3 MUSK SPEG

8.48e-03421364IPR003599
DomainSH3_domain

MAP3K9 PRMT2 ARHGEF4

8.65e-03220363IPR001452
Pubmed

Structure and expression of two members of the d4 gene family in mouse.

DPF1 DPF2

1.36e-06241210602997
Pubmed

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

DPF1 DPF2

4.06e-06341218765789
Pubmed

The d4 gene family in the human genome.

DPF1 DPF2

4.06e-0634128812431
Pubmed

The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.

PPP4C SKP1

2.84e-05741224362026
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

DPF1 KMT2D DPF2 SKP1

3.55e-0515741430186101
Pubmed

Association and mutation analyses of 16p11.2 autism candidate genes.

PPP4C SEZ6L2

3.78e-05841219242545
Pubmed

Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.

FNIP1 CSF2RB

3.78e-05841218804346
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

WDR90 KMT2D ARHGEF4 ESPL1 CDC42BPB CDK12 SPEG NBEAL2

3.81e-05110541835748872
Pubmed

Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells.

IL15RA CSF2RB

6.07e-051041234568787
Pubmed

Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer.

DPF1 DPF2

7.41e-051141222334708
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

DPF1 KMT2D DPF2

1.09e-047841328611094
Pubmed

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.

ROBO3 EPHA5

1.61e-041641227223328
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PRMT2 GALNT6 PPP4C CDC42BPB CDK12 GALNT16

2.01e-0473041634857952
Pubmed

Functional genomics identifies therapeutic targets for MYC-driven cancer.

HAUS7 CDK12 SPEG

2.48e-0410341322623531
Pubmed

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

KMT2D SKP1

2.54e-042041232350066
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

MYOM2 PPP4C SKP1 SPEG NBEAL2

2.86e-0449741536774506
Pubmed

Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.

ROBO3 EPHA5

3.38e-042341224360543
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT6 GALNT16

3.68e-042441231740596
Pubmed

Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.

GALNT6 GALNT16

3.68e-042441231882545
Pubmed

The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.

DPF1 DPF2

3.68e-042441212215535
Pubmed

SWI/SNF chromatin remodeling and cancer.

DPF1 DPF2

3.68e-042441211790558
Pubmed

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.

DPF1 DPF2

3.68e-042441210078207
Pubmed

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.

DPF1 DPF2

4.33e-042641210778858
Pubmed

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.

SEZ6L2 ZNF254

5.03e-042841223006423
Pubmed

REST repression of neuronal genes requires components of the hSWI.SNF complex.

DPF1 DPF2

5.03e-042841212192000
Pubmed

Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.

DPF1 DPF2

5.78e-043041231043422
Pubmed

Interaction network of human early embryonic transcription factors.

DPF1 KMT2D DPF2 SLX4

7.69e-0435141438297188
Pubmed

The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.

DPF1 DPF2

7.87e-043541232504627
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

GALNT6 GALNT16

8.33e-043641225615642
Pubmed

O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.

GALNT6 GALNT16

1.03e-034041222643896
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

KMT2D PPP4C CDK12

1.07e-0317041316159877
Pubmed

Genomic analysis of mouse retinal development.

AKR1E2 IL15RA PPP4C ROBO3 SEZ6L2 ZNF254

1.09e-03100641615226823
InteractionGCM1 interactions

DPF1 KMT2D DPF2 SKP1

8.02e-0668384int:GCM1
InteractionETV5 interactions

DPF1 KMT2D SEZ6L2

3.25e-0533383int:ETV5
Cytoband10p15.1

AKR1E2 IL15RA

2.90e-042841210p15.1
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1E2 IL15RA

2.97e-0390412chr10p15
GeneFamilyWD repeat domain containing|BEACH domain containing

WDR81 NBEAL2

1.15e-0493321230
GeneFamilyFibronectin type III domain containing

MYOM2 ROBO3 CSF2RB EPHA5

1.98e-04160334555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

MYOM2 ROBO3 MUSK SPEG

2.03e-04161334593
GeneFamilyPHD finger proteins

DPF1 KMT2D DPF2

5.84e-049033388
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT6 GALNT16

6.01e-0420332433
GeneFamilyCyclin dependent kinases

CDK12 CDK7

1.02e-0326332496
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

IL15RA SEZ6L2

4.84e-03573321179
GeneFamilyImmunoglobulin like domain containing

MYOM2 ROBO3 MUSK

5.16e-03193333594
GeneFamilyWD repeat domain containing

WDR81 WDR90 NBEAL2

1.19e-02262333362
DiseaseKunitz-type protease inhibitor 2 measurement

DPF1 RASGRP4

7.61e-0510392EFO_0008200
Diseasephosphatidylethanolamine ether measurement

GALNT16 MUSK

7.61e-0510392EFO_0010229
Diseaselysophosphatidylethanolamine 18:2 measurement

AKR1E2 MUSK

5.42e-0426392EFO_0010369
Diseaselysophosphatidylethanolamine 20:4 measurement

AKR1E2 MUSK

6.76e-0429392EFO_0010370
DiseaseLarge cell carcinoma of lung

CDC42BPB EPHA5

8.23e-0432392C0345958
DiseaseGastric Adenocarcinoma

MAP3K9 SPEG

1.63e-0345392C0278701
Diseasealcohol use disorder (implicated_via_orthology)

DPF1 ZNF683 DPF2

2.18e-03195393DOID:1574 (implicated_via_orthology)
Diseasefree cholesterol to total lipids in very large HDL percentage

CDK12 MUSK

2.42e-0355392EFO_0022288
Diseasebasophil count, eosinophil count

FNIP1 RASGRP4 MUSK

3.96e-03241393EFO_0004842, EFO_0005090
Diseasemethylcobalamin deficiency type cblE

SEZ6L2 ZNF254

4.33e-0374392MONDO_0009354

Protein segments in the cluster

PeptideGeneStartEntry
WPTMAALHLVPCSAD

PRMT2

241

P55345
SKMAPPDLPHWQDCH

CDK12

1026

Q9NYV4
SPPMAEPPEGSWSCH

DPF1

356

Q92782
PPKMHCSAEGEWLVP

EPHA5

271

P54756
MPWEEPAGEKPSCSH

ARHGEF4

1

Q9NR80
SDKEWCPPSDPDFSM

ARMC3

711

Q5W041
KHLDPACAADPWEAP

LINC00313

41

P59037
DSHCEVNTEWLPPML

GALNT16

211

Q8N428
ITCPPPMSVEHADIW

IL15RA

31

Q13261
HTPDITKAEPCPWEA

GPR179

1371

Q6PRD1
NIALTPECASMPWDP

C19orf85

131

A0A1B0GUS0
WETDTVPCPVMDPPS

RASGRP4

651

Q8TDF6
MSSCPVHDCPSWDPE

LCA10

1

Q71F78
MWPAAPVACSCSPTH

CDC42BPB

1461

Q9Y5S2
PCSPEHMAEPVTFWV

ESPL1

536

Q14674
DLSDDMPWSACPHPR

CSF2RB

76

P32927
MPAGYHCPLDSAPWD

DMRTC2

6

Q8IXT2
TPTEEQWPDMCSLPD

CDK7

231

P50613
AMAPCNPSDPHQLWL

GALNT6

606

Q8NCL4
LPCWNHSDPESMSLF

FNIP1

821

Q8TF40
WPEHCSESMFPSQHP

LINC00574

46

Q9H8X3
SPHLQMLLNPECDPW

HAUS7

171

Q99871
LMEDCWNPDPHSRPS

MAP3K9

381

P80192
HAWLCLHPMDTAPTP

NBEAL2

606

Q6ZNJ1
MPASATAAWHCPPLC

PRR34

1

Q9NV39
PTEPHWNDTEPACKA

SEZ6L2

511

Q6UXD5
DSDPPIPIDDCCWHM

SLX4

1416

Q8IY92
IPIDDCCWHMEPLSP

SLX4

1421

Q8IY92
CCWHMEPLSPIPIDH

SLX4

1426

Q8IY92
GFKPPHPEWIMSCSE

AKR1E2

106

Q96JD6
DPQPHCSAGPVWDDM

UBE2DNL

16

Q8IWF7
NHCELVDWLSFPMPA

WDR90

1611

Q96KV7
LPAACPAPHISWMKD

SPEG

2606

Q15772
EEWCPPMPERSHLTE

ROBO3

1111

Q96MS0
MSEPPEGSWSCHLCL

DPF2

361

Q92785
WCTHHKDDPPPPEDD

SKP1

61

P63208
VPHDGPMCDLLWSDP

PPP4C

186

P60510
MENCDPLPNPWTSTH

UBQLN3

296

Q9H347
HPDMPDLDVPAWCSS

WDR81

506

Q562E7
DEPPGMCPHFAQDLW

ZNF254

81

O75437
LPDMVDAHGPSCASW

ZNF683

46

Q8IZ20
FCLKPPMEELPAHSW

KMT2D

301

O14686
VPECSKLPSMHWDPT

MUSK

431

O15146
PSDPSEHFKCEAWTM

MYOM2

796

P54296
EHFKCEAWTMPEPGP

MYOM2

801

P54296