Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscerebellum maturation

CACNA1A CEND1

3.04e-054472GO:0021590
MousePhenoabnormal Purkinje cell dendrite morphology

WDR81 CACNA1A CEND1 MAPK8IP2 GAS1

3.04e-0758355MP:0008572
MousePhenoabnormal fear/anxiety-related behavior

ZNF521 CACNA1A DGKQ PRDM8 KIF3B ARIH1 LMTK3 DAGLA HCN1 MAPK8IP2 RYR3

9.01e-069193511MP:0002065
MousePhenoabnormal cerebellar molecular layer

CACNA1A CEND1 MAPK8IP2 GAS1

1.66e-0562354MP:0000889
MousePhenoabnormal hindbrain morphology

WDR81 ZNF521 CACNA1A AMBRA1 CEND1 ERF MAPK8IP2 GAS1

2.04e-05485358MP:0000841
MousePhenoabnormal dendrite morphology

WDR81 CACNA1A CEND1 KIF3B MAPK8IP2 GAS1

2.40e-05237356MP:0008143
MousePhenoabnormal nervous system development

ZNF521 CACNA1A AMBRA1 TEAD2 PRDM8 CEND1 KIF3B ERF BRD1 ARPC5 MED12 GAS1

3.12e-0512573512MP:0003861
MousePhenoabnormal synaptic transmission

ZNF521 CACNA1A AMBRA1 ADGRL1 PRDM8 KIF3B ARIH1 DAGLA TMPRSS6 MAPK8IP2 RYR3

3.77e-0510703511MP:0003635
MousePhenoabnormal synaptic physiology

ZNF521 CACNA1A AMBRA1 ADGRL1 PRDM8 KIF3B ARIH1 DAGLA TMPRSS6 MAPK8IP2 RYR3

3.97e-0510763511MP:0021009
MousePhenothin cerebellar molecular layer

CACNA1A CEND1 MAPK8IP2

5.57e-0530353MP:0000890
MousePhenoabnormal anxiety-related response

ZNF521 DGKQ PRDM8 KIF3B ARIH1 LMTK3 DAGLA HCN1 MAPK8IP2

6.33e-05740359MP:0001362
MousePhenoabnormal CNS synaptic transmission

ZNF521 CACNA1A AMBRA1 PRDM8 KIF3B ARIH1 DAGLA TMPRSS6 MAPK8IP2 RYR3

1.04e-049853510MP:0002206
MousePhenodecreased neuronal precursor cell number

ZNF521 DAGLA GAS1

1.05e-0437353MP:0004981
MousePhenodecreased anxiety-related response

ZNF521 DGKQ KIF3B ARIH1 LMTK3 DAGLA MAPK8IP2

1.08e-04452357MP:0001364
MousePhenoabnormal Purkinje cell morphology

WDR81 CACNA1A CEND1 MAPK8IP2 GAS1

1.43e-04204355MP:0000877
MousePhenodecreased synaptic glutamate release

ADGRL1 MAPK8IP2

1.69e-048352MP:0004495
MousePhenoabnormal cerebellar Purkinje cell layer

WDR81 CACNA1A CEND1 MAPK8IP2 GAS1

2.04e-04220355MP:0000875
MousePhenoopen neural tube

AMBRA1 KIF3B ERF BRD1 MED12

2.31e-04226355MP:0000929
MousePhenoabnormal neuronal precursor cell number

ZNF521 DAGLA GAS1

2.92e-0452353MP:0004979
MousePhenoabnormal cerebellum external granule cell layer morphology

CACNA1A CEND1 GAS1

2.92e-0452353MP:0000872
MousePhenoabnormal neural tube closure

AMBRA1 KIF3B ERF BRD1 ARPC5 MED12

3.14e-04378356MP:0003720
MousePhenoabnormal neuron mitochondrial morphology

WDR81 CACNA1A

3.30e-0411352MP:0014345
MousePhenoabnormal cerebellum morphology

WDR81 ZNF521 CACNA1A CEND1 MAPK8IP2 GAS1

3.66e-04389356MP:0000849
MousePhenoabnormal cerebellar layer morphology

WDR81 CACNA1A CEND1 MAPK8IP2 GAS1

4.64e-04263355MP:0009956
MousePhenoabnormal synaptic glutamate release

ADGRL1 MAPK8IP2

4.67e-0413352MP:0004494
MousePhenoabnormal metencephalon morphology

WDR81 ZNF521 CACNA1A CEND1 MAPK8IP2 GAS1

5.50e-04420356MP:0000847
MousePhenoabnormal social/conspecific interaction behavior

ZNF521 CACNA1A ADGRL1 KIF3B LMTK3 MAPK8IP2

5.57e-04421356MP:0002557
MousePhenoabnormal neural tube morphology

AMBRA1 KIF3B ERF BRD1 ARPC5 MED12 GAS1

5.57e-04591357MP:0002151
MousePhenoabnormal neurotransmitter secretion

CACNA1A ADGRL1 MAPK8IP2

6.17e-0467353MP:0005445
MousePhenoabnormal Purkinje cell size

CACNA1A GAS1

6.27e-0415352MP:0014326
MousePhenodecreased Purkinje cell size

CACNA1A GAS1

6.27e-0415352MP:0014327
MousePhenoabnormal neurite morphology

WDR81 CACNA1A CEND1 KIF3B MAPK8IP2 GAS1

7.19e-04442356MP:0008415
MousePhenoabnormal cerebellar cortex morphology

WDR81 CACNA1A CEND1 MAPK8IP2 GAS1

8.43e-04300355MP:0004097
MousePhenoabnormal long-term depression

KIF3B DAGLA RYR3

1.11e-0382353MP:0001898
MousePhenoabnormal stride length

WDR81 CACNA1A CEND1

1.11e-0382353MP:0012690
MousePhenoabnormal cerebellar granule layer morphology

WDR81 CACNA1A GAS1

1.23e-0385353MP:0000886
MousePhenoabnormal NMDA-mediated synaptic currents

KIF3B MAPK8IP2

1.36e-0322352MP:0002888
DomainBEACH_dom

WDR81 LRBA

2.11e-049462IPR000409
DomainBEACH

WDR81 LRBA

2.11e-049462PS50197
DomainBeach

WDR81 LRBA

2.11e-049462PF02138
Domain-

WDR81 LRBA

2.11e-0494621.10.1540.10
DomainBeach

WDR81 LRBA

2.11e-049462SM01026
Domain-

PSD2 CYTH3

6.11e-04154621.10.1000.11
DomainSec7

PSD2 CYTH3

6.11e-0415462PF01369
DomainSec7_alpha_orthog

PSD2 CYTH3

6.11e-0415462IPR023394
DomainSec7

PSD2 CYTH3

6.97e-0416462SM00222
DomainSEC7

PSD2 CYTH3

6.97e-0416462PS50190
DomainSec7_dom

PSD2 CYTH3

6.97e-0416462IPR000904
DomainIon_trans_dom

CACNA1A HCN1 RYR3

2.78e-03114463IPR005821
DomainIon_trans

CACNA1A HCN1 RYR3

2.78e-03114463PF00520
Domain-

ZNF521 SPIRE2 ARIH1 BRD1 RING1

4.78e-034494653.30.40.10
DomainZnf_RING/FYVE/PHD

ZNF521 SPIRE2 ARIH1 BRD1 RING1

5.25e-03459465IPR013083
DomainWD40_repeat_dom

WDR81 AMBRA1 LRBA GTF3C4

6.05e-03297464IPR017986
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

WDR81 CACNA1A PPP1R3F KIF3B MDN1 LMTK3 CYTH3 HCN1 MAPK8IP2 PURB

5.17e-07963471028671696
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DGKQ AMBRA1 ADGRL1 TEAD2 SPIRE2 MDN1 LRBA MED12 CYTH3 SGSM2

1.79e-061105471035748872
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PRMT6 ZNF668 SPIRE2 KIF3B MDN1 NAIF1 GTF3C4 PURB

3.62e-0668947836543142
Pubmed

Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

CACNA1A RYR3

5.36e-06347218313230
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

CACNA1A PPP1R3F PSD2 LMTK3 MAPK8IP2

1.58e-0523347537704626
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

MDN1 LRBA ARIH1 RING1

2.85e-0512947423022380
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF521 LRBA CYTH3 AKAP8L HCN1 GTF3C4 SGSM2 MAPK8IP2 RYR3

4.79e-05128547935914814
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

MDN1 LRBA MED12 AKAP8L GTF3C4 RYR3

5.40e-0549747636774506
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF521 ERF MED12 AKAP8L RING1

1.10e-0435147538297188
Pubmed

Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.

CACNA1A LMTK3

2.12e-041647225113059
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

AMBRA1 ZNF668 ERF RCC2 AKAP8L GTF3C4

2.43e-0465547635819319
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

AMBRA1 ARIH1 AKAP8L MAPK8IP2

2.75e-0423247425515538
Pubmed

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.

RCC2 AKAP8L RING1

2.93e-049547329490077
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

PSD2 CYTH3

3.01e-041947230674481
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CACTIN ZNF668 MDN1 ERF NAIF1 RCC2 GTF3C4 RING1

3.10e-04129447830804502
Pubmed

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.

MDN1 RING1

3.69e-042147237014752
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

KIF3B MED12 AKAP8L GTF3C4 PURB

3.92e-0446247531138677
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PRMT6 CACTIN MDN1 ARIH1 MED12 GTF3C4 RING1

3.99e-04101447732416067
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

MDN1 GTF3C4 RING1

5.27e-0411647321549307
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

ZNF668 MDN1 RCC2 MED12 AKAP8L GTF3C4

5.31e-0475947635915203
Pubmed

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.

CACNA1A CEND1

5.69e-042647235165395
Pubmed

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.

ZNF521 MED12

6.61e-042847211984006
Pubmed

Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.

HCN1 GAS1

6.61e-042847235942939
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TMEM63B ADGRL1 LRBA ARIH1 DAGLA ARPC5 SGSM2 TMPRSS6

7.85e-04148947828611215
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A DGKQ

9.19e-043347219336002
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A RYR3

1.22e-033847230786075
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CACNA1A ADGRL1 LMTK3 HCN1

1.24e-0334747417114649
GeneFamilyWD repeat domain containing|BEACH domain containing

WDR81 LRBA

1.08e-0493221230
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

WDR81 PPP1R3F LMTK3

3.95e-03181323694
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A LMTK3 HCN1 MAPK8IP2 PURB

1.79e-061884851efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MDN1 DAGLA CYTH3 RYR3

2.28e-0515448416fdafb5c64d2db321554f87129a962d113f1668
ToppCelldroplet-Heart-nan-24m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A PSD2 DAGLA GAS1

2.59e-051594847ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

PRDM8 LMTK3 HCN1 PURB

3.14e-051674849efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

PRDM8 LMTK3 HCN1 PURB

3.14e-05167484904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellTuft-tuft-4|World / Class top

PPP1R3F TEAD2 SPIRE2 MDN1

3.68e-05174484d6f306ebf66061bf9e9742000bfedce12d277452
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD4 ZNF521 PRDM8 RYR3

3.68e-05174484ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|390C / Donor, Lineage, Cell class and subclass (all cells)

PRMT6 PPP1R3F ZBTB45 PRDM8

4.48e-05183484228092290dbb08785c4eda224e3ad03e99e10fab
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PRMT6 PPP1R3F ZBTB45 PRDM8

4.77e-0518648474eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCellCerebellum-Neuronal|Cerebellum / BrainAtlas - Mouse McCarroll V32

SPIRE2 LMTK3 HCN1 PURB

4.87e-0518748461b9d6eb131a674598aa8409d7fa909c8765442d
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

THSD4 AMBRA1 LRBA ARIH1

5.51e-05193484779276e775cb2492e8dd36436295a536084a6415
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 AMBRA1 XKR6 LRBA

5.85e-05196484ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 AMBRA1 XKR6 LRBA

6.08e-051984841996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 AMBRA1 XKR6 LRBA

6.20e-0519948494b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ADGRL1 HCN1 MAPK8IP2 PURB

6.20e-05199484f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
Diseasecigarettes per day measurement

AMBRA1 ZNF668 SPIRE2 KIF3B LRBA SGSM2

5.86e-05438466EFO_0006525
DiseaseTremor, Rubral

CACNA1A HCN1

2.81e-0416462C0750940
DiseaseAtaxia, Appendicular

CACNA1A HCN1

2.81e-0416462C0750937
DiseaseAtaxia, Motor

CACNA1A HCN1

2.81e-0416462C0278161
DiseaseAbnormal coordination

CACNA1A HCN1

2.81e-0416462C0520966
DiseaseAtaxia, Truncal

CACNA1A HCN1

2.81e-0416462C0427190
DiseaseAtaxia, Sensory

CACNA1A HCN1

2.81e-0416462C0240991
Diseaseage at first sexual intercourse measurement

ZNF521 AMBRA1 XKR6 KIF3B HCN1

3.18e-04383465EFO_0009749
DiseaseAtaxia

CACNA1A HCN1

6.97e-0425462C0004134
Diseasephosphatidylcholine 38:4 measurement

DAGLA GAS1

8.76e-0428462EFO_0010386
DiseaseEpileptic encephalopathy

CACNA1A RYR3

1.01e-0330462C0543888
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

CACNA1A HCN1

1.07e-0331462DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ARGGEGEGEGPDGGE

CACNA1A

986

O00555
GGGGPAGGFEDEGED

ERF

496

P50548
GPGLEGFEEDGAALG

BRD1

766

O95696
GGGEEEAGGPGGADR

ADGRL1

1316

O94910
GPGDGAEEDEAASGG

CEND1

96

Q8N111
EAAEPGEGGDGADGS

DGKQ

266

P52824
GPGEGEGSEYGASGE

AMBRA1

1131

Q9C0C7
PGLDVEDDEEGGGGA

AKAP8L

631

Q9ULX6
DEEDGGDGQAGPDEG

ARPC5

26

O15511
SGDEDGLELDGAPGG

RCC2

51

Q9P258
PGEGDGGGHLDSEGE

GOLGA8S

416

H3BPF8
GGGGGPGHEQEEDYR

ARIH1

86

Q9Y4X5
EFHDYEGGGIGEGEG

MDN1

4671

Q9NU22
EGGEAPGPTEEDGAG

NAIF1

91

Q69YI7
GGAEPGADSAEGDVG

MMP15

581

P51511
EGDVGDGDGDFGAGV

MMP15

591

P51511
EEEGDGEGQEGGDPG

MAPK8IP2

101

Q13387
GGAGAPGPAEEDGED

LMTK3

1266

Q96Q04
DDGGGGGREETPTEG

LRBA

16

P50851
TEELPEEEGGGGSGG

MED12

1246

Q93074
AGGEDAGSGAEDVGP

GOLGA6L2

561

Q8N9W4
EDAGAGEEDMGPGGE

GOLGA6L2

611

Q8N9W4
GAEDVGPEGEDVGAG

GOLGA6L2

721

Q8N9W4
EDAGPGGEDAGAGGE

GOLGA6L2

816

Q8N9W4
DAGPGGEDAGAGGED

GOLGA6L2

831

Q8N9W4
AGGEDAGPGGEDVGP

GOLGA6L2

841

Q8N9W4
AGPGGEDVGPGGEDV

GOLGA6L2

846

Q8N9W4
EDVGPGGEDVGAGGE

GOLGA6L2

851

Q8N9W4
GGAGGEQPLDDDDGV

GAS1

276

P54826
EEEGGGEEGEEGGGG

FAM9A

241

Q8IZU1
GEEGEEGGGGGEGEE

FAM9A

246

Q8IZU1
GGGGEEPAGGFEDAE

HCN1

71

O60741
VDGDGDGAPGSSGDE

TMEM63B

781

Q5T3F8
MDEDGGGEGGGVPED

CYTH3

1

O43739
SGGGGEGGEGTEEED

PRMT6

11

Q96LA8
NDEEEEVGGGGGGPA

DAGLA

876

Q9Y4D2
TPTEGDGDGDGEGEG

CACTIN

521

Q8WUQ7
GGEGEPGEGEGDGED

RING1

171

Q06587
DDYGGEDDELAGGPG

PURB

191

Q96QR8
FPEEAAEGGGGAGLV

PRDM8

316

Q9NQV8
FEEEDGGGEEGSSGP

SGSM2

731

O43147
EGAGGDGGPDAEGVW

TEAD2

31

Q15562
DEAVGSGGEEDGEPG

XKR6

21

Q5GH73
DETDGEDGEGGGPGE

ZBTB45

216

Q96K62
GPLEGAGEAGGEEAD

ZNF668

496

Q96K58
GVAGSGEGEPGEDAG

ZBP1

351

Q9H171
GGGSGGGGEEEEEEG

KIF3B

386

O15066
GFHEDGPQGPGGDED

PSD2

246

Q9BQI7
AGGGIGDEIEDPAGD

RYR3

4726

Q15413
GCGAADEGYGGPEEE

SPIRE2

141

Q8WWL2
HGEGCDFGEEEGGPG

ZNF521

101

Q96K83
GEEDAGGGGEGAPSE

SMIM44

106

A0A286YF18
QDGGGGGGADEDDDG

PPP1R3F

71

Q6ZSY5
PAPSGEEEGEGGGEA

GTF3C4

16

Q9UKN8
EEEGEGGGEAGGKEP

GTF3C4

21

Q9UKN8
EGAPEDDGGGGAPGV

THSD4

41

Q6ZMP0
GGSGGDGEEEEEALP

WDR81

1196

Q562E7
PQVAGGQGDGGDGEE

TMPRSS6

16

Q8IU80
GQGDGGDGEEAEPEG

TMPRSS6

21

Q8IU80