Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	DDR1 IGF1R ROR1 ROR2	1.34e-04	65	80	4	GO:0004714
GeneOntologyMolecularFunction	lysine-acetylated histone binding	KMT2A DPF2 THAP7	2.33e-04	30	80	3	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	KMT2A DPF2 THAP7	2.57e-04	31	80	3	GO:0140033
GeneOntologyMolecularFunction	protein tyrosine kinase activity	DDR1 IGF1R MATK ROR1 ROR2	2.92e-04	145	80	5	GO:0004713
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	DDR1 IGF1R ROR1 ROR2	3.78e-04	85	80	4	GO:0019199
Domain	Tyr_kinase_rcpt_ROR	ROR1 ROR2	1.68e-05	2	77	2	IPR016247
Domain	TyrKc	DDR1 IGF1R MATK ROR1 ROR2	3.13e-05	88	77	5	SM00219
Domain	Tyr_kinase_cat_dom	DDR1 IGF1R MATK ROR1 ROR2	3.13e-05	88	77	5	IPR020635
Domain	Kringle	HGFAC ROR1 ROR2	4.39e-05	17	77	3	IPR000001
Domain	Kringle_CS	HGFAC ROR1 ROR2	4.39e-05	17	77	3	IPR018056
Domain	KRINGLE_2	HGFAC ROR1 ROR2	4.39e-05	17	77	3	PS50070
Domain	Kringle	HGFAC ROR1 ROR2	4.39e-05	17	77	3	PF00051
Domain	KRINGLE_1	HGFAC ROR1 ROR2	4.39e-05	17	77	3	PS00021
Domain	KR	HGFAC ROR1 ROR2	4.39e-05	17	77	3	SM00130
Domain	PROTEIN_KINASE_TYR	DDR1 IGF1R MATK ROR1 ROR2	5.01e-05	97	77	5	PS00109
Domain	Tyr_kinase_AS	DDR1 IGF1R MATK ROR1 ROR2	5.01e-05	97	77	5	IPR008266
Domain	FAM47	FAM47C FAM47B	1.00e-04	4	77	2	PF14642
Domain	FAM47	FAM47C FAM47B	1.00e-04	4	77	2	IPR032743
Domain	Pkinase_Tyr	DDR1 IGF1R MATK ROR1 ROR2	1.93e-04	129	77	5	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	DDR1 IGF1R MATK ROR1 ROR2	2.64e-04	138	77	5	IPR001245
Domain	Kringle-like	HGFAC ROR1 ROR2	3.07e-04	32	77	3	IPR013806
Domain	Znf_PHD	TRIM33 ASXL1 KMT2A DPF2	5.44e-04	91	77	4	IPR001965
Domain	ZF_PHD_2	TRIM33 ASXL1 KMT2A DPF2	6.40e-04	95	77	4	PS50016
Domain	ZF_PHD_1	TRIM33 ASXL1 KMT2A DPF2	6.66e-04	96	77	4	PS01359
Domain	Tyr_kinase_rcpt_2_CS	DDR1 IGF1R	9.01e-04	11	77	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	DDR1 IGF1R	1.08e-03	12	77	2	PS00239
Domain	Kinase-like_dom	DDR1 IGF1R MATK ROR1 ROR2 WDR81 DCLK2 EIF2AK4	1.73e-03	542	77	8	IPR011009
Domain	-	BMP4 CGB1 NGF	2.67e-03	67	77	3	2.10.90.10
Domain	Cystine-knot_cytokine	BMP4 CGB1 NGF	2.67e-03	67	77	3	IPR029034
Domain	PROTEIN_KINASE_ATP	DDR1 IGF1R MATK ROR1 ROR2 DCLK2 EIF2AK4	2.83e-03	459	77	7	PS00107
Domain	PHD	TRIM33 KMT2A DPF2	3.68e-03	75	77	3	PF00628
Domain	Prot_kinase_dom	DDR1 IGF1R MATK ROR1 ROR2 DCLK2 EIF2AK4	4.01e-03	489	77	7	IPR000719
Domain	PROTEIN_KINASE_DOM	DDR1 IGF1R MATK ROR1 ROR2 DCLK2 EIF2AK4	4.19e-03	493	77	7	PS50011
Domain	Znf_PHD-finger	TRIM33 KMT2A DPF2	4.26e-03	79	77	3	IPR019787
Domain	Frizzled_dom	ROR1 ROR2	4.37e-03	24	77	2	IPR020067
Domain	FZ	ROR1 ROR2	4.37e-03	24	77	2	PS50038
Domain	Fz	ROR1 ROR2	4.37e-03	24	77	2	PF01392
Domain	PHD	TRIM33 KMT2A DPF2	5.93e-03	89	77	3	SM00249
Pubmed	The protein tyrosine kinase family of the human genome.	DDR1 IGF1R MATK ROR1 ROR2	1.52e-06	83	81	5	11114734
Pubmed	Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.	ROR1 ROR2	5.36e-06	2	81	2	11429290
Pubmed	ROR1 and ROR2 expression in pancreatic cancer.	ROR1 ROR2	5.36e-06	2	81	2	34763666
Pubmed	IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.	IGF1R ROR1	5.36e-06	2	81	2	26173023
Pubmed	A novel family of cell surface receptors with tyrosine kinase-like domain.	ROR1 ROR2	5.36e-06	2	81	2	1334494
Pubmed	Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.	ROR1 ROR2	5.36e-06	2	81	2	15654020
Pubmed	Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.	ROR1 ROR2	5.36e-06	2	81	2	25029443
Pubmed	Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development.	ROR1 ROR2	5.36e-06	2	81	2	11455430
Pubmed	Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion.	ROR1 ROR2	5.36e-06	2	81	2	26515598
Pubmed	Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.	ROR1 ROR2	5.36e-06	2	81	2	11713269
Pubmed	The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation.	ROR1 ROR2	5.36e-06	2	81	2	34155901
Pubmed	Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies.	ROR1 ROR2	5.36e-06	2	81	2	22988987
Pubmed	β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.	ROR1 ROR2	5.36e-06	2	81	2	26862065
Pubmed	ROR1 and ROR2 play distinct and opposing roles in endometrial cancer.	ROR1 ROR2	5.36e-06	2	81	2	29395309
Pubmed	HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway.	IGF1R HOXB13	5.36e-06	2	81	2	33894267
Pubmed	Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression.	ROR1 ROR2	5.36e-06	2	81	2	37430307
Pubmed	Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.	ROR1 ROR2	5.36e-06	2	81	2	10231392
Pubmed	Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.	ROR1 ROR2	5.36e-06	2	81	2	24104062
Pubmed	Role of the Ror family receptors in Wnt5a signaling.	ROR1 ROR2	5.36e-06	2	81	2	38587578
Pubmed	Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons.	ROR1 ROR2	5.36e-06	2	81	2	12898527
Pubmed	Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons.	ROR1 ROR2	1.60e-05	3	81	2	19958813
Pubmed	Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells.	DDR1 IGF1R	1.60e-05	3	81	2	27384677
Pubmed	Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation.	ROR1 ROR2	1.60e-05	3	81	2	26690702
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 IGF1R EXPH5 MATK ROR2 ZBTB21 KMT2A MAGI3 DCLK2 SRRM2	3.15e-05	861	81	10	36931259
Pubmed	The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution.	ROR1 ROR2	3.20e-05	4	81	2	12754255
Pubmed	Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.	PRPF8 SRRM2	3.20e-05	4	81	2	29361316
Pubmed	Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.	ROR1 ROR2	3.20e-05	4	81	2	26840931
Pubmed	IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.	IGF1R MATK	3.20e-05	4	81	2	21799000
Pubmed	Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.	ROR1 ROR2	3.20e-05	4	81	2	28885975
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PCF11 TRIM33 ZBTB21 KMT2A DPF2 CHAMP1	3.96e-05	268	81	6	33640491
Pubmed	Quantitative trait loci affecting peak bone mineral density in mice.	BMP4 IGF1R	5.33e-05	5	81	2	9797472
Pubmed	Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling.	ROR1 ROR2	5.33e-05	5	81	2	25043182
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	IGF1R AKAP17A NTHL1 ROR1 ROR2 SRRM2 RPL3	5.74e-05	420	81	7	28065597
Pubmed	Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.	ROR1 ROR2	7.99e-05	6	81	2	22328498
Pubmed	p300-mediated acetylation stabilizes the Th-inducing POK factor.	PRPF8 ZBTB7B	7.99e-05	6	81	2	20810990
Pubmed	Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.	ROR1 ROR2	1.12e-04	7	81	2	22343533
Pubmed	Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis.	IGF1R ROR2	1.12e-04	7	81	2	33480845
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	DDR1 IGF1R ROR2	1.13e-04	40	81	3	30898150
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	ASXL1 KMT2A	1.49e-04	8	81	2	22722839
Pubmed	Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants.	ROR1 ROR2	1.49e-04	8	81	2	30801848
Pubmed	Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression.	CACNA2D2 TNNI1	1.49e-04	8	81	2	31306714
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCF11 TBC1D9B EXPH5 GNPTAB MAGI3 PFAS FHDC1	1.55e-04	493	81	7	15368895
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TRIM33 DPF2 PRPF8 CHAMP1 HOXB13	1.68e-04	220	81	5	35785414
Pubmed	Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth.	BMP4 ROR2	2.38e-04	10	81	2	21246660
Pubmed	Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.	BMP4 ROR2	2.38e-04	10	81	2	25082826
Pubmed	trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.	IGF1R NGF	2.91e-04	11	81	2	8223273
Pubmed	Bmp4 from the optic vesicle specifies murine retina formation.	BMP4 FOXE3	2.91e-04	11	81	2	25792196
Pubmed	Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.	BMP4 ROR2	2.91e-04	11	81	2	18948417
Pubmed	Aebp2 as an epigenetic regulator for neural crest cells.	BMP4 AEBP2	2.91e-04	11	81	2	21949878
Pubmed	Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly.	BMP4 ROR2	3.48e-04	12	81	2	29292497
Pubmed	Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.	BMP4 NGF	4.11e-04	13	81	2	18087045
Pubmed	Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo.	BMP4 NGF	4.11e-04	13	81	2	14973275
Pubmed	Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.	NGF CORO7	4.11e-04	13	81	2	24270184
Pubmed	A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.	IGF1R NGF	4.79e-04	14	81	2	8114702
Pubmed	Expression of insulin-like growth factor binding proteins during mouse cochlear development.	BMP4 IGF1R	4.79e-04	14	81	2	23813480
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	PCF11 ADAMTSL1 NRF1 MATK AEBP2 MAGI3 FHDC1 ZNF804A	6.21e-04	814	81	8	23251661
Pubmed	Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family.	BMP4 IGF1R	6.29e-04	16	81	2	23584732
Pubmed	A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.	ROR2 NGF	6.29e-04	16	81	2	35714603
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DDR1 SHROOM3 IGF1R NRF1 CACNA2D2 ROR2 LRRC27 XPNPEP3 MAGI3 DCLK2 EIF2AK4	6.60e-04	1489	81	11	28611215
Pubmed	Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning.	BMP4 ROR2	8.00e-04	18	81	2	29428562
Pubmed	Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded.	CGB1 ROR1	8.00e-04	18	81	2	20593419
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	TRIM33 AEBP2	8.00e-04	18	81	2	28068325
Pubmed	Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation.	BMP4 CGB1	8.93e-04	19	81	2	28938441
Pubmed	BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.	PRPF8 SRRM2	8.93e-04	19	81	2	25263594
Pubmed	Requirement for Mab21l2 during development of murine retina and ventral body wall.	BMP4 FOXE3	8.93e-04	19	81	2	15385160
Pubmed	Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.	ACTN3 TNNI1	9.91e-04	20	81	2	22267199
Pubmed	Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region.	BMP4 ROR2	9.91e-04	20	81	2	20660756
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	ASXL1 LIN37 AEBP2 KMT2A CHAMP1 SCAI	1.06e-03	495	81	6	27705803
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	BMP4 SHROOM3 TBC1D9B IGF1R DNAJC14 NRF1 PFAS HOXB13 WDR24	1.07e-03	1105	81	9	35748872
Pubmed	Pancreatic islet and progenitor cell surface markers with cell sorting potential.	DDR1 ROR2 GJC1	1.08e-03	86	81	3	21947380
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	IGF1R EXPH5 IGHMBP2 KMT2A EIF2AK4 PRPF8	1.09e-03	497	81	6	36774506
Pubmed	The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q.	IGF1R CGB1	1.09e-03	21	81	2	2307474
Pubmed	Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.	IGF1R FOXE3	1.09e-03	21	81	2	12072567
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TRIM33 CCPG1 IGF1R COL13A1 ZBTB21 PFAS DPF2	1.14e-03	689	81	7	36543142
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	TRIM33 LIN37 KMT2A PRPF8 CHAMP1	1.19e-03	339	81	5	30415952
Pubmed	Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication.	CGB1 NGF	1.20e-03	22	81	2	8452817
Pubmed	MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.	ROR1 ROR2	1.20e-03	22	81	2	34032267
Pubmed	An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.	BMP4 CGB1	1.31e-03	23	81	2	36800350
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	IGHMBP2 KMT2A DPF2 ZBTB7B CHAMP1 HOXB13 THAP7	1.34e-03	709	81	7	22988430
Pubmed	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	WDR81 PRPF8	1.43e-03	24	81	2	20705733
Pubmed	Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.	TRIM33 BMP4	1.43e-03	24	81	2	20573697
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CEP78 NTHL1 KMT2A DPF2 SRRM2 RPL3	1.55e-03	533	81	6	30554943
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PCF11 LINC00322 NTHL1 SRRM2 WDR24	1.58e-03	361	81	5	26167880
Pubmed	β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis.	BMP4 CGB1	1.68e-03	26	81	2	27184910
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	PANK1 PSRC1	1.68e-03	26	81	2	19060910
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	DDR1 IGF1R ROR1	1.72e-03	101	81	3	23382219
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	DDR1 IGF1R MATK ROR2 DCLK2	1.80e-03	372	81	5	22939624
Pubmed	Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.	BMP4 CGB1	1.81e-03	27	81	2	26764381
Pubmed	Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.	ROR1 ROR2	1.81e-03	27	81	2	31257105
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CCPG1 GNPTAB ZBTB21	1.82e-03	103	81	3	10574462
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	CCPG1 SCARF2 ROR2 PRPF8 RPL3	1.86e-03	375	81	5	32788342
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCF11 ZBTB21 KMT2A MAGI3 FAM47B EIF2AK4 ACTN3 PLA2G4D PRPF8 RPL3	1.88e-03	1442	81	10	35575683
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	DDR1 IGF1R	1.95e-03	28	81	2	18593464
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	BMP4 IGF1R NRF1 ROR2 ZBTB7B	2.04e-03	383	81	5	19453261
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TRIM33 DDR1 IGF1R COL13A1 DEDD2 GJC1 EIF2AK4 CHAMP1 PSRC1	2.06e-03	1215	81	9	15146197
Pubmed	Direct and indirect requirements of Shh/Gli signaling in early pituitary development.	BMP4 CGB1	2.09e-03	29	81	2	20934421
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	SRRM2 THAP7	2.09e-03	29	81	2	17577209
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	DPF2 SRRM2	2.09e-03	29	81	2	19279220
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	ROR1 ROR2	2.09e-03	29	81	2	22956684
Pubmed	Noggin regulates Bmp4 activity during pituitary induction.	BMP4 CGB1	2.09e-03	29	81	2	17359964
Cytoband	Ensembl 112 genes in cytogenetic band chr1p13	TRIM33 NGF MAGI3 PSRC1	5.47e-04	211	81	4	chr1p13
Cytoband	16p13.3	NTHL1 CORO7 SRRM2 WDR24	9.40e-04	244	81	4	16p13.3
Cytoband	4q31.3	DCLK2 FHDC1	1.38e-03	31	81	2	4q31.3
Cytoband	1p13.1	TRIM33 NGF	1.57e-03	33	81	2	1p13.1
Cytoband	Xp21.1	FAM47C FAM47B	1.66e-03	34	81	2	Xp21.1
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	DDR1 IGF1R ROR1 ROR2	4.05e-06	40	49	4	321
CoexpressionAtlas	facebase_RNAseq_e8.5_FloorPlate_2500_K3	BMP4 SHROOM3 CCPG1 CEP78 NRF1 CACNA2D2 IQCC GNPTAB LRRC27 FHDC1 ACTN3 TNNI1 SRRM2 PSRC1 ZNF710 WDR24 USP21 THAP7	9.54e-07	1371	75	18	facebase_RNAseq_e8.5_FloorPlate_2500_K3
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR1 ROR2 AEBP2 KMT2A MAGI3 SCAI	1.23e-06	188	81	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR1 ROR2 AEBP2 KMT2A MAGI3 SCAI	1.23e-06	188	81	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROR1 ROR2 AEBP2 KMT2A MAGI3 SCAI	1.23e-06	188	81	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.23e-06	188	81	6	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.39e-06	192	81	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.52e-06	195	81	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CEP78 CACNA2D2 MATK GNPTAB KMT2A SRRM2	1.61e-06	197	81	6	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.71e-06	199	81	6	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.71e-06	199	81	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 CACNA2D2 EXPH5 ROR1 MAGI3 SCAI	1.71e-06	199	81	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP4 COL13A1 SCARF2 ROR1 TNS2	1.07e-05	159	81	5	34c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BMP4 SHROOM3 ROR1 MAGI3 SCAI	1.60e-05	173	81	5	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 ADAMTSL1 CEP78 MAGI3 SCAI	1.74e-05	176	81	5	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 ADAMTSL1 IGF1R MATK PANK1	1.79e-05	177	81	5	9b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CARMIL3 MATK DCLK2 TNNI1 PLA2G4D	1.84e-05	178	81	5	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ADAMTSL1 IGF1R MATK ACTN3	1.84e-05	178	81	5	cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 ADAMTSL1 CEP78 MAGI3 DCLK2	1.84e-05	178	81	5	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 EXPH5 ROR1 MAGI3 SCAI	1.89e-05	179	81	5	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 ADAMTSL1 MAGI3 DCLK2 SCAI	1.94e-05	180	81	5	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC BMP4 ADAMTSL1 MATK ACTN3	1.94e-05	180	81	5	41e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SHROOM3 EXPH5 ROR1 MAGI3 SCAI	2.10e-05	183	81	5	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHROOM3 ADAMTSL1 ROR1 MAGI3 SCAI	2.16e-05	184	81	5	29c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC IGF1R MATK ACTN3 PANK1	2.21e-05	185	81	5	5527fa9d2e0b2f3607602e18ba94de4e9bbc6824
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	ASXL1 ADAMTSL1 CEP78 MAGI3 DCLK2	2.33e-05	187	81	5	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHROOM3 ADAMTSL1 ROR1 AEBP2 MAGI3	2.52e-05	190	81	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 CACNA2D2 EXPH5 MAGI3 SCAI	2.58e-05	191	81	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	SHROOM3 CACNA2D2 EXPH5 MAGI3 SCAI	2.65e-05	192	81	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 CACNA2D2 ROR1 MAGI3 SCAI	2.78e-05	194	81	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IQCC NTHL1 NIBAN3 PANK1 USP21	2.85e-05	195	81	5	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	SHROOM3 EXPH5 ROR1 MAGI3 SCAI	3.07e-05	198	81	5	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 CACNA2D2 ROR1 MAGI3 SCAI	3.14e-05	199	81	5	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CEP78 MATK GNPTAB KMT2A SRRM2	3.22e-05	200	81	5	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)\|Striatum / BrainAtlas - Mouse McCarroll V32	EXPH5 LRRC27 FHDC1 SHCBP1L	8.78e-05	128	81	4	7e3f5cea91af005f08d8e9340fb8630bf1c887c3
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Striatum / BrainAtlas - Mouse McCarroll V32	EXPH5 LRRC27 FHDC1 SHCBP1L	8.78e-05	128	81	4	a876303c852db2af9418d1a1711d7c950805018a
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)-\|Striatum / BrainAtlas - Mouse McCarroll V32	EXPH5 LRRC27 FHDC1 SHCBP1L	8.78e-05	128	81	4	388062f840fd04cb8087f27a9a78e7a192920e3e
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPDYE1 DNAJC14 TNS2 CHAMP1	9.05e-05	129	81	4	2f30b4897343586c9b49a1d2bec3007ec737085c
ToppCell	AT1-AT2_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	EXPH5 ROR1 MAGI3 SCAI	1.24e-04	140	81	4	45d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-2\|TCGA-Thryoid / Sample_Type by Project: Shred V9	HGFAC CGB1 PLA2G4D RAPGEFL1	1.31e-04	142	81	4	112f1b1bf7622e3bc1a2094c7710fab5a4083481
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 DEDD2 MAGI3 CORO7	1.46e-04	146	81	4	ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2\|TCGA-Lung / Sample_Type by Project: Shred V9	CEP78 ACTN3 PSRC1 FOXE3	1.97e-04	158	81	4	9dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCell	10x5'-Lung-Lymphocytic_B-ABC_aged-B_memory\|Lung / Manually curated celltypes from each tissue	CARMIL3 ROR1 DCLK2 NIBAN3	2.02e-04	159	81	4	d3202ddc291b8686dbe67690df13c7daffec2199
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 IGF1R MAGI3 PANK1	2.02e-04	159	81	4	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRIM33 CEP78 MATK RAPGEFL1	2.12e-04	161	81	4	bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 ADAMTSL1 CEP78 MAGI3	2.33e-04	165	81	4	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BMP4 CACNA2D2 NGF ZNF804A	2.38e-04	166	81	4	b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D2 TNS2 PSRC1 SCAI	2.44e-04	167	81	4	dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQCC DEDD2 WDR81 ZBTB7B	2.44e-04	167	81	4	9b9b4cad0b35d121256176600ea4705759c105d3
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CARMIL3 MATK DCLK2 TNNI1	2.49e-04	168	81	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	Control\|World / group, cell type (main and fine annotations)	SHROOM3 CACNA2D2 EXPH5 MAGI3	2.49e-04	168	81	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D2 MATK NIBAN3 KCNH4	2.49e-04	168	81	4	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D2 MATK NIBAN3 KCNH4	2.49e-04	168	81	4	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DNAJC14 IQCC SCARF2 MAGI3	2.55e-04	169	81	4	2833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 ROR1 MAGI3 SCAI	2.55e-04	169	81	4	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D2 TNS2 PSRC1 SCAI	2.61e-04	170	81	4	4a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCell	facs-Heart-RV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF2 ROR2 FHDC1 PSRC1	2.61e-04	170	81	4	d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP78 CACNA2D2 MATK GNPTAB	2.73e-04	172	81	4	86f52f486d67217fc1b8443ab362c975df2974a4
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDR1 ROR1 PFAS EIF2AK4	2.73e-04	172	81	4	b043d4f81dced7fb3326043f68474123be47cc5d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP78 CACNA2D2 MATK GNPTAB	2.73e-04	172	81	4	fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP78 CACNA2D2 MATK GNPTAB	2.73e-04	172	81	4	e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR1 ROR1 PFAS EIF2AK4	2.79e-04	173	81	4	6c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	SHROOM3 ROR1 MAGI3 SCAI	2.85e-04	174	81	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CACNA2D2 ROR1 MAGI3 FHDC1	2.91e-04	175	81	4	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA2D2 ROR1 NGF ZNF804A	2.91e-04	175	81	4	955f10982a487e12cdc3a9f80b3be06bf6c59de7
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EXPH5 DEDD2 AEBP2 KCNH4	2.98e-04	176	81	4	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DDR1 SCARF2 ROR2 NGF	3.04e-04	177	81	4	b75f519d72611b293d9684f7dcfb1b70fbf54a90
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC ADAMTSL1 IGF1R MATK	3.04e-04	177	81	4	c1f838e425ebb04482829b1957e3c1347127e6de
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 ROR1 MAGI3 SCAI	3.17e-04	179	81	4	cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 ROR1 MAGI3 SCAI	3.17e-04	179	81	4	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 SHROOM3 ROR1 MAGI3	3.17e-04	179	81	4	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	SHROOM3 CACNA2D2 MAGI3 FHDC1	3.24e-04	180	81	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP4 SHROOM3 COL13A1 EXPH5	3.24e-04	180	81	4	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA2D2 ROR1 NGF ZNF804A	3.31e-04	181	81	4	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 SHROOM3 ROR1 MAGI3	3.31e-04	181	81	4	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 SHROOM3 ADAMTSL1 MAGI3	3.31e-04	181	81	4	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	AT1-AT2_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	EXPH5 ROR1 MAGI3 SCAI	3.31e-04	181	81	4	ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ASXL1 ADAMTSL1 MAGI3 DCLK2	3.38e-04	182	81	4	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	21-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	CEP78 IQCC ZBTB21 FOXE3	3.38e-04	182	81	4	6e35892fa959ee31591850ded8f1088195ddeb01
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA2D2 ROR1 NGF ZNF804A	3.45e-04	183	81	4	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	CACNA2D2 CARMIL3 MATK GNPTAB	3.45e-04	183	81	4	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA2D2 ROR1 NGF ZNF804A	3.45e-04	183	81	4	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	SHROOM3 EXPH5 ROR1 MAGI3	3.45e-04	183	81	4	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 SHROOM3 ROR1 MAGI3	3.52e-04	184	81	4	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	droplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 SHROOM3 COL13A1 SCARF2	3.52e-04	184	81	4	89ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ROR1 MAGI3 SCAI	3.52e-04	184	81	4	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 SHROOM3 COL13A1 SCARF2	3.52e-04	184	81	4	4df6027fa635996c1eddb920f88a5265772df1cd
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	SHROOM3 ROR1 MAGI3 SCAI	3.52e-04	184	81	4	561592edc3083fad41b91811151b442207c65dd9
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ROR1 MAGI3 SCAI	3.52e-04	184	81	4	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 ROR1 MAGI3 SCAI	3.60e-04	185	81	4	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	CEP78 IQCC ZBTB21 FOXE3	3.60e-04	185	81	4	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	Control-Epithelial-ATI\|World / Disease state, Lineage and Cell class	SHROOM3 CACNA2D2 ROR1 MAGI3	3.60e-04	185	81	4	0563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMH+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CEP78 CACNA2D2 MATK FAM47B	3.60e-04	185	81	4	097d628f92e13250c15b550f2fd1f4225fc07558
ToppCell	normal-na-Lymphocytic_NK-NK_dim-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	COL13A1 CEP78 MATK GNPTAB	3.60e-04	185	81	4	b1a8a8c4d0fc7605eabc17dcb6bd9e8ab4fd578c
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 SHROOM3 ROR1 MAGI3	3.60e-04	185	81	4	c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCPG1 IGHMBP2 KMT2A CORO7	3.67e-04	186	81	4	39e475a3c167b33daa63b0c1bfa32451c5f46635
ToppCell	COVID-19_Moderate-NK_activated\|World / disease group, cell group and cell class	CEP78 MATK GNPTAB GBP1	3.67e-04	186	81	4	ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 SHROOM3 COL13A1 SCARF2	3.67e-04	186	81	4	ca5e9c6531cb5d199e27509bfab1d62e3937177e
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP4 SHROOM3 COL13A1 SCARF2	3.67e-04	186	81	4	1ed71b229f40a680071b14f5a7a19706e0fd14b1
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDR1 SHROOM3 ROR1 MAGI3	3.67e-04	186	81	4	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	Epithelial-alveolar_epithelial_cell_type_1\|World / Lineage, Cell type, age group and donor	SHROOM3 ROR1 MAGI3 SCAI	3.67e-04	186	81	4	09d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCPG1 IGHMBP2 KMT2A CORO7	3.67e-04	186	81	4	02418c50fdcca549bf73dedf6199ab4a27862a9b
Drug	Artemisinin [63968-64-9]; Down 200; 14.2uM; PC3; HT_HG-U133A	METTL25B LIN37 IGF1R XPNPEP3 GJC1 TNS2 SRRM2	4.21e-06	199	75	7	7247_DN
Disease	lysosomal Pro-X carboxypeptidase measurement	PCF11 GNPTAB	1.77e-04	8	75	2	EFO_0801777
Disease	myelofibrosis (is_implicated_in)	ASXL1 KMT2A	1.77e-04	8	75	2	DOID:4971 (is_implicated_in)
Disease	myelodysplastic syndrome (implicated_via_orthology)	ASXL1 PRPF8	6.55e-04	15	75	2	DOID:0050908 (implicated_via_orthology)
Disease	Lewy Body Disease	IGF1R NGF	1.42e-03	22	75	2	C0752347
Disease	physical activity	PCF11 ADAMTSL1 AEBP2	1.48e-03	88	75	3	EFO_0003940
Disease	Adenocarcinoma of large intestine	MATK ROR1 ROR2	1.90e-03	96	75	3	C1319315
Disease	longevity, healthspan, parental longevity	MAGI3 PSRC1	2.48e-03	29	75	2	EFO_0004300, EFO_0007796, EFO_0009762

Protein segments in the cluster

Peptide	Gene	Start	Entry
IQRRSARPPRAKEKH	CEP295NL	156	Q96MC4
ARPPRAKEKHRAALS	CEP295NL	161	Q96MC4
KRRRSLPRPHDFFDA	AEBP2	386	Q6ZN18
RAPKKIDLYDVRRRP	CACNA2D2	266	Q9NY47
RVFRPRKLDRFHPKE	EIF2AK4	1141	Q9P2K8
PRVDFPRSRLRFKEK	DDR1	601	Q08345
RHVKGRVDPHFRAPK	CGB1	16	A6NKQ9
ERAKRHRGFPLIKTR	CEP78	396	Q5JTW2
HLARKRRRPVSPERY	DEDD2	101	Q8WXF8
GHALTRRRRAKRSPK	BMP4	281	P12644
GHFKKRSRPDLRTRA	ASXL1	406	Q8IXJ9
HKLRIKSRASGRVPR	NFILZ	266	A0A5F9ZHS7
RGLKPRNHCPRKSRT	IQCC	326	Q4KMZ1
RSKKLPRVREHRGPL	NIBAN3	91	Q86XR2
NRPPRSSKAHRKRER	OTUD6A	86	Q7L8S5
AKRKHRRLRFPPVDT	FAM47C	31	Q5HY64
LRRASSARAPKKRPE	FHDC1	1086	Q9C0D6
KPPSRRQRHRFPTKE	DNAJC14	191	Q6Y2X3
TGKRPSARFPHQRRK	LIN37	61	Q96GY3
ARRPPFRKLAEKLAR	MATK	466	P42679
IRHFREPIRLKTVKP	MAGI3	91	Q5TCQ9
TVDPRLFKKRRLRSP	NGF	71	P01138
PRRRIHKEASPNRIR	GNPTAB	1241	Q3T906
PLQKKRRRGLFHFRR	CARMIL3	1046	Q8ND23
HFEERDKRPRPGSRR	DCLK2	11	Q8N568
GSRRPHRKPTILRKI	ADAMTSL1	1156	Q8N6G6
VSKFRHTEARPPRRE	CORO7	6	P57737
LHNSIFVPRPERKRR	IGF1R	726	P08069
LRPRRYRAPSHDKVA	OR2V1	261	Q8NHB1
AKRKHRRLRFPPVDT	FAM47B	31	Q8NA70
RKRPHVFESNPSIRK	NRF1	91	Q16656
KDFIRVHRLPRPLKQ	KCNH4	496	Q9UQ05
ASRKFPAKDVSPRRH	EXPH5	1601	Q8NEV8
LLRKSHPPKVRERHF	EXPH5	1806	Q8NEV8
PKKKCFVFDRPVHRR	GBP1	231	P32455
RLTAPFRKHVRPKKQ	METTL25B	121	Q96FB5
RRVKPSPRRETFVLK	PSRC1	106	Q6PGN9
RRHKKRTFLRPRIIG	HGFAC	396	Q04756
KSRSPIIHSPKRRDR	PCF11	486	O94913
IIHSPKRRDRRSPKR	PCF11	491	O94913
PSPAFRRRRARKKTV	CCPG1	171	Q9ULG6
SREKPRFHKPCRNDL	LINC00322	26	Q6ZN03
RKRALFPEPRKHALF	CHAMP1	546	Q96JM3
SQPKPKHDGRRRIRE	GJC1	156	P36383
GAQKRRHKPRRADSP	IFNL4	136	K9M1U5
RHKPRRADSPRCRKA	IFNL4	141	K9M1U5
RKRKVFSPIRSEPRS	KMT2A	736	Q03164
KLHSRRRREAPKTSP	COL13A1	101	Q5TAT6
HPPDACAFRRGRKKR	HOXB13	206	Q92826
KRVRDLRHPKRILFG	PRAMEF26	346	H0Y7S4
PQHDSPAKKCRLRRR	PANK1	211	Q8TE04
RTALKHRTLEARPPR	PLA2G4D	801	Q86XP0
QPRRKRLKSDERPVH	TRIM33	1111	Q9UPN9
KRPNPDILDHERKRR	SRRM2	51	Q9UQ35
LPKPRHVFRRKTASS	LRRC27	301	Q9C0I9
FLPRKRSSRHRGKVK	RPL3	16	P39023
SHSPVKRPRKAQRLR	NTHL1	51	P78549
LRRRKRFKRAELPAH	FOXE3	161	Q13461
HGPFFPRILRRRKGK	SHCBP1L	361	Q9BZQ2
KLRLKHRRSEPAGRP	SHROOM3	146	Q8TF72
EFPSRRPRFKDIHSR	ROR2	731	Q01974
RPIRPHRNISALKRD	TBC1D9B	266	Q66K14
RGISFHRLPKKDNPR	THAP7	21	Q9BT49
RDYRRLHKPPRIQEK	ACTN3	331	Q08043
SREDGRPRKERRPHK	AKAP17A	611	Q02040
EIPSRRPRFKDIHVR	ROR1	731	Q01973
RDRRHFKRMRFPPFD	PRPF8	156	Q6P2Q9
PAKRRFQADRRLPFK	ZBTB21	481	Q9ULJ3
KLPFAPRARSKERRN	USP21	26	Q9UK80
PVARRSRKPRKAFLQ	ZBTB7B	196	O15156
RSFKRRPKLPDNEVH	TRAPPC11	721	Q7Z392
KRRFITVSKRAPRPR	IGHMBP2	776	P38935
RKKAPHRLCGRFSRI	SCARF2	486	Q96GP6
HPRAGAELRRFRKRP	PFAS	1136	O15067
RPREHSLKKRGTRSL	SOGA1	116	O94964
PRARKNRSHIPLVRK	SPDYE1	256	Q8NFV5
CEKHTRRKTRPPVRL	ZNF710	91	Q8N1W2
GKFKRPPLRRVRVSA	TNNI1	106	P19237
ARRWRKKRRAHPPED	DPF2	76	Q92785
KKRRAHPPEDPRLSF	DPF2	81	Q92785
PPRKRRSRTEFALKE	SCAI	26	Q8N9R8
SHKAILFVPRRDPSR	XPNPEP3	146	Q9NQH7
GDRRHPIFFKRKLDP	WDR24	371	Q96S15
PSKQVKPLFRHFRRI	RAPGEFL1	286	Q9UHV5
RAASRPRKAEPHSFR	TNS2	21	Q63HR2
PRKAEPHSFREKVFR	TNS2	26	Q63HR2
TPHGRFRDLRKSKFR	WDR81	391	Q562E7
KRRRKRGRFHPGFET	ZNF804A	811	Q7Z570