Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase

ST3GAL1 ST3GAL2

2.15e-053542GO:0047288
GeneOntologyMolecularFunctionbeta-galactoside (CMP) alpha-2,3-sialyltransferase activity

ST3GAL1 ST3GAL2

1.49e-047542GO:0003836
GeneOntologyBiologicalProcessglycosphingolipid metabolic process

NEU2 A3GALT2 SMPD1 ST3GAL1 ST3GAL2

1.46e-0673555GO:0006687
GeneOntologyBiologicalProcessglycolipid metabolic process

NEU2 A3GALT2 SMPD1 ST3GAL1 ST3GAL2

1.62e-05119555GO:0006664
GeneOntologyBiologicalProcessliposaccharide metabolic process

NEU2 A3GALT2 SMPD1 ST3GAL1 ST3GAL2

1.69e-05120555GO:1903509
GeneOntologyBiologicalProcessprotein sialylation

ST3GAL1 ST3GAL2

4.17e-054552GO:1990743
GeneOntologyBiologicalProcessganglioside metabolic process

NEU2 ST3GAL1 ST3GAL2

6.24e-0529553GO:0001573
GeneOntologyBiologicalProcessganglioside biosynthetic process via lactosylceramide

ST3GAL1 ST3GAL2

1.04e-046552GO:0010706
GeneOntologyBiologicalProcesssphingolipid metabolic process

NEU2 A3GALT2 SMPD1 ST3GAL1 ST3GAL2

1.05e-04176555GO:0006665
GeneOntologyBiologicalProcessribosome-associated ubiquitin-dependent protein catabolic process

NEMF ASCC3

1.45e-047552GO:1990116
GeneOntologyBiologicalProcessglycosphingolipid biosynthetic process

A3GALT2 ST3GAL1 ST3GAL2

1.78e-0441553GO:0006688
GeneOntologyBiologicalProcessceramide metabolic process

NEU2 SMPD1 ST3GAL1 ST3GAL2

2.35e-04113554GO:0006672
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

A3GALT2 SMPD1 ST3GAL1 ST3GAL2

2.68e-04117554GO:0030148
GeneOntologyBiologicalProcesscarbohydrate metabolic process

NEU2 MAN2C1 GALT A3GALT2 OGDHL ST3GAL2 FGL1 SLC23A1

2.94e-04646558GO:0005975
GeneOntologyBiologicalProcesssialylation

ST3GAL1 ST3GAL2

3.10e-0410552GO:0097503
GeneOntologyBiologicalProcesscarbohydrate derivative metabolic process

NEU2 GALT ASGR2 A3GALT2 OGDHL SMPD1 ST3GAL1 ST3GAL2 EXTL3 OGG1 ADCY2

3.33e-0412265511GO:1901135
GeneOntologyBiologicalProcessmembrane lipid metabolic process

NEU2 A3GALT2 SMPD1 ST3GAL1 ST3GAL2

3.58e-04229555GO:0006643
GeneOntologyBiologicalProcesslipid glycosylation

A3GALT2 ST3GAL2

5.34e-0413552GO:0030259
DomainSialyl_trans

ST3GAL1 ST3GAL2

8.72e-0415552IPR012163
DomainGlyco_trans_29

ST3GAL1 ST3GAL2

1.56e-0320552IPR001675
DomainGlyco_transf_29

ST3GAL1 ST3GAL2

1.56e-0320552PF00777
DomainTRYPSIN_SER

C1RL KLK2 TMPRSS11A

2.37e-0390553IPR033116
DomainTRYPSIN_HIS

C1RL KLK2 TMPRSS11A

3.47e-03103553IPR018114
DomainTRYPSIN_SER

C1RL KLK2 TMPRSS11A

3.76e-03106553PS00135
DomainTRYPSIN_HIS

C1RL KLK2 TMPRSS11A

3.86e-03107553PS00134
DomainPeptidase_S1A

C1RL KLK2 TMPRSS11A

4.50e-03113553IPR001314
DomainTRYPSIN_DOM

C1RL KLK2 TMPRSS11A

4.73e-03115553PS50240
DomainTryp_SPc

C1RL KLK2 TMPRSS11A

4.96e-03117553SM00020
DomainTrypsin

C1RL KLK2 TMPRSS11A

5.45e-03121553PF00089
DomainTrypsin_dom

C1RL KLK2 TMPRSS11A

5.45e-03121553IPR001254
DomainPeptidase_S1_PA

C1RL KLK2 TMPRSS11A

5.70e-03123553IPR009003
DomainFERM_M

PTPN21 KRIT1

8.11e-0346552PF00373
DomainCUB

C1RL DMBT1

9.16e-0349552PF00431
Domain-

PTPN21 KRIT1

9.16e-03495521.20.80.10
DomainFERM_central

PTPN21 KRIT1

9.16e-0349552IPR019748
DomainFERM_domain

PTPN21 KRIT1

9.16e-0349552IPR000299
DomainFERM_1

PTPN21 KRIT1

9.53e-0350552PS00660
DomainFERM_2

PTPN21 KRIT1

9.53e-0350552PS00661
DomainFERM_3

PTPN21 KRIT1

9.53e-0350552PS50057
DomainBand_41_domain

PTPN21 KRIT1

9.53e-0350552IPR019749
DomainCUB

C1RL DMBT1

9.53e-0350552SM00042
PathwayWP_GANGLIO_SPHINGOLIPID_METABOLISM

A3GALT2 ST3GAL1 ST3GAL2

5.94e-0613403M39730
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

ST3GAL1 ST3GAL2 MUC4

2.72e-0521403MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

ST3GAL1 ST3GAL2 MUC4

3.60e-0523403M556
PathwayREACTOME_SIALIC_ACID_METABOLISM

NEU2 ST3GAL1 ST3GAL2

1.09e-0433403MM15038
PathwayREACTOME_SIALIC_ACID_METABOLISM

NEU2 ST3GAL1 ST3GAL2

1.09e-0433403M27319
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD7A ST3GAL1 ST3GAL2 MUC4

2.49e-04109404MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

THSD7A ST3GAL1 ST3GAL2 MUC4

2.67e-04111404M27416
PathwayREACTOME_MATURATION_OF_PROTEIN_3A

ST3GAL1 ST3GAL2

2.79e-049402M39012
PathwayREACTOME_GLYCOSPHINGOLIPID_METABOLISM

NEU2 SMPD1 ST3GAL2

4.49e-0453403MM14647
PathwayREACTOME_GLYCOSPHINGOLIPID_METABOLISM

NEU2 SMPD1 ST3GAL2

5.86e-0458403M576
PathwayWP_GANGLIO_SERIES_SPHINGOLIPID_METABOLISM

ST3GAL1 ST3GAL2

6.00e-0413402M46459
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

ST3GAL1 ST3GAL2 MUC4

6.47e-0460403MM15636
PathwayKEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES

ST3GAL1 ST3GAL2

6.99e-0414402M12899
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

ST3GAL1 ST3GAL2 MUC4

7.13e-0462403M546
PathwayREACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS

NEU2 ST3GAL1 ST3GAL2

7.82e-0464403M892
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE

ST3GAL1 ST3GAL2

8.05e-0415402M3042
PathwayKEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES

ST3GAL1 ST3GAL2

8.05e-0415402M8535
PathwayKEGG_OTHER_GLYCAN_DEGRADATION

NEU2 MAN2C1

9.19e-0416402M17844
PathwayREACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN

NEU2 ST3GAL1 ST3GAL2

1.34e-0377403MM15118
PathwayREACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN

NEU2 ST3GAL1 ST3GAL2

1.44e-0379403M897
PathwayREACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION

NEU2 ASGR2 ST3GAL1 ST3GAL2 RNF139

1.67e-03307405M894
Pubmed

Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.

ST3GAL1 ST3GAL2

2.55e-06256235507766
Pubmed

Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase.

ST3GAL1 ST3GAL2

7.63e-0635628144500
Pubmed

Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies.

ST3GAL1 ST3GAL2

7.63e-0635627655169
Pubmed

Sialyltransferase specificity in selectin ligand formation.

ST3GAL1 ST3GAL2

1.52e-05456212393657
Pubmed

Biosynthesis of the major brain gangliosides GD1a and GT1b.

ST3GAL1 ST3GAL2

1.52e-05456222735313
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

TBKBP1 FGL1 SPRTN OGG1 GTF3C4 SEC14L5

1.57e-0533256637433992
Pubmed

Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression.

ST3GAL1 ST3GAL2

2.54e-0555629184827
Pubmed

Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.

MAN2C1 ST3GAL1 ST3GAL2

2.96e-05375632542563
Pubmed

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

MAN2C1 ST3GAL1 ST3GAL2

2.96e-05375632541446
Pubmed

Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

MAN2C1 ST3GAL1 ST3GAL2

3.20e-05385632829950
Pubmed

Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.

MAN2C1 ST3GAL1 ST3GAL2

3.20e-05385632187500
Pubmed

Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse.

ST3GAL1 ST3GAL2

3.80e-05656210894948
Pubmed

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.

ST3GAL1 ST3GAL2

3.80e-05656235452678
Pubmed

Utility of incorporating genetic variants for the early detection of prostate cancer.

OGG1 KLK2

5.32e-05756219223501
Pubmed

Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.

MAN2C1 ST3GAL1 ST3GAL2

5.71e-05465632649653
Pubmed

Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.

KLK2 RYR1

1.66e-04125628288260
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

IFNGR2 ASCC3 OGG1 SLC23A1 IL6R

2.55e-0435156520453000
Pubmed

Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR.

ST3GAL1 ST3GAL2

2.64e-041556210381338
Pubmed

Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.

NEU2 MAN2C1

2.64e-04155628892864
Pubmed

Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.

OGG1 TMPRSS11A

3.01e-041656219826048
Pubmed

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.

KLHDC2 ZER1

3.83e-041856218187417
Pubmed

Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women.

IFNGR2 IL6R

8.07e-042656219505916
Pubmed

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

ZNF462 RYR1

1.08e-033056220080650
Pubmed

Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains.

NEU2 ST3GAL2

1.22e-033256217883393
Pubmed

A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.

ST3GAL1 ST3GAL2

1.30e-033356223118208
Pubmed

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

RABGGTA TWF1

1.46e-033556215188402
Pubmed

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.

PPP1R12B KLK2

1.46e-033556223936387
Pubmed

A Novel Interacting Protein SERP1 Regulates the N-Linked Glycosylation and Function of GLP-1 Receptor in the Liver.

ASGR2 FGL1

1.46e-033556228597972
GeneFamilySialyltransferases

ST3GAL1 ST3GAL2

7.98e-0420382438
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN21 KRIT1

4.94e-03503821293
Drugsodium chloride

PLB1 NEU2 MAN2C1 GALT CD22 ASGR2 A3GALT2 C1RL ST3GAL1 RNF139 KLK2 SLC23A1

8.16e-078655512CID000000206
DrugPNU-0293363 [326823-19-2]; Down 200; 10uM; MCF7; HT_HG-U133A

CD22 ZER1 SMPD1 ST3GAL2 EXTL3 FGL1

7.92e-061975566573_DN
DiseasePapillary Renal Cell Carcinoma

RNF139 OGG1 MUC4 IL6R RYR1

3.79e-06128545C1306837
DiseaseRenal Cell Carcinoma

RNF139 OGG1 MUC4 IL6R RYR1

3.79e-06128545C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

RNF139 OGG1 MUC4 IL6R RYR1

3.79e-06128545C1266043
DiseaseChromophobe Renal Cell Carcinoma

RNF139 OGG1 MUC4 IL6R RYR1

3.79e-06128545C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

RNF139 OGG1 MUC4 IL6R RYR1

3.79e-06128545C1266044
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

RNF139 OGG1 MUC4 IL6R RYR1

7.70e-06148545C0279702
DiseaseRENAL CELL CARCINOMA, NONPAPILLARY

RNF139 OGG1

6.86e-057542144700
DiseaseHereditary clear cell renal cell carcinoma

RNF139 OGG1

6.86e-057542C1333985
DiseaseNonpapillary renal cell carcinoma

RNF139 OGG1

6.86e-057542cv:CN074294
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

PKD2L1 LRP5L

2.95e-0414542DOID:898 (implicated_via_orthology)
Diseaseurate measurement, bone density

PLB1 SYNE1 DMBT1 CA10 DNAH9 SLC23A1

9.14e-04619546EFO_0003923, EFO_0004531
Diseasepolyunsaturated fatty acid measurement

NTAN1 TBKBP1 ASGR2

1.80e-03131543EFO_0010733

Protein segments in the cluster

PeptideGeneStartEntry
SFPGRQHNVWESHAW

C2orf16

866

Q68DN1
YKNWAVTQPDNWHGH

ASGR2

256

P07307
YWTGDIPAHDVWHQT

SMPD1

276

P17405
HWSWVANTLNPYHEA

CMTR2

166

Q8IYT2
ASHSYYWNAQRHPSW

DDX20

791

Q9UHI6
TWDHFWLNEGHTVYL

LTA4H

311

P09960
VTWVNAHAYPAQWTL

MUC4

4451

Q99102
HAVAPYWNNGAETSW

PARP15

166

Q460N3
QPWQVAVYSHGWAHC

KLK2

36

P20151
DPYNTTENMHWEWSH

KIAA0100

1156

Q14667
SAWWVYHHQVSKTAP

NEMF

611

O60524
SRWTVHYTAPWHQQE

NHSL1

76

Q5SYE7
YFAWLENPQSVHKSW

OGDHL

56

Q9ULD0
LLGDFIYWTAWQHHS

LRP5L

171

A4QPB2
QLDSDHWAPIHYACW

KRIT1

316

O00522
MWHIAQRDYSWHPTT

OGG1

271

O15527
TVWHLQYTDWPEHGC

PTPN21

1056

Q16825
QWLLYTHPTHSWQRA

NEU2

291

Q9Y3R4
WQYDVWSHDVTLANH

ADCY2

401

Q08462
PSAWVQHADYSWYQA

IGSF8

546

Q969P0
VTWQDPHSWNSSFYR

IL6R

236

P08887
AGNFHPEVQWWASHQ

FGL1

216

Q08830
ANWNHWQLHAHYYPP

GALT

311

P07902
HAWDIPHQSWLYNSN

EXTL3

776

O43909
GHFSHVIWFHPTWAQ

C5orf22

91

Q49AR2
SGSVYVVWDNHAHHW

C1RL

436

Q9NZP8
SVAQLHSWHYHWPSW

A3GALT2

216

U3KPV4
GHLQRPTHYNTSWDW

MAN2C1

831

Q9NTJ4
ALHSAWVTMPWFQHY

IFNGR2

121

P38484
SFWNSSHPRGWNDHV

KLHDC2

181

Q9Y2U9
TAIHWFHEWPQQALE

DNAH9

2976

Q9NYC9
AQQNSPKIHEGWWAY

CA10

21

Q9NS85
HESYLWSCPHNGWLT

DMBT1

306

Q9UGM3
ESYLWSCPHNGWLSH

DMBT1

436

Q9UGM3
ESYLWSCPHNGWLSH

DMBT1

806

Q9UGM3
ESYLWSCPHNGWLSH

DMBT1

1066

Q9UGM3
HESYLWSCPHNGWLS

DMBT1

1581

Q9UGM3
HTDQLWQWSETYHSA

SEC14L5

501

O43304
CVWAGWVTPDYHQHD

RYR1

1446

P21817
HYTWFDWNNQSLPYH

CD22

626

P20273
WHHYALNTWLFAVTA

RNF139

411

Q8WU17
HSDCNQYLWVTEPWS

THSD7A

1091

Q9UPZ6
HWTRYQSESADLIHW

SYNE1

6796

Q8NF91
HENTSGLWSIWYRNH

TMEM131L

401

A2VDJ0
TDPNDQSAWFYHRWL

RABGGTA

221

Q92696
ADSKGNWHHYWENNP

ST3GAL1

291

Q11201
NWHHYWENNPSAGAF

ST3GAL1

296

Q11201
ADSRGNWHHYWENNR

ST3GAL2

301

Q16842
SWTPFPHVDFWLHQD

NTAN1

231

Q96AB6
WNLQHGISSFSYWHQ

PLB1

1296

Q6P1J6
WIWVEDPTNDHIYHS

ASCC3

1221

Q8N3C0
INIWALHHNPYFWED

CYP4Z1

406

Q86W10
PVSQHWATWALYNLV

ZER1

696

Q7Z7L7
YGNWSLPLNTSHIWH

SLC23A1

136

Q9UHI7
TSPSVLFWWEYEHNN

GTF3C4

311

Q9UKN8
WTKWYNNQSLGHGSH

PKD2L1

171

Q9P0L9
PSAHDYWWAEHQKTC

SPRTN

191

Q9H040
IWDITNHYQAFHPWA

ZNF462

1381

Q96JM2
NSTSVPAWQWLAHVY

TTC37

1396

Q6PGP7
HYWEVDVTHSSNWIL

TRIM64C

341

A6NLI5
AATAYAHAEHAQSWP

TBKBP1

556

A7MCY6
YEWIFIAWSPDHSHV

TWF1

81

Q12792
AAWPWQASLQYDNIH

TMPRSS11A

196

Q6ZMR5
QDYDGWTPLHAAAHW

PPP1R12B

246

O60237