Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	1.99e-08	18	97	5	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	2.19e-07	28	97	5	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	9.39e-07	37	97	5	GO:0045505
GeneOntologyMolecularFunction	microtubule motor activity	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	2.30e-05	70	97	5	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO9B DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	2.39e-05	118	97	6	GO:0003774
GeneOntologyMolecularFunction	nodal binding	CFC1 CFC1B	6.42e-04	8	97	2	GO:0038100
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	B3GALNT2 GALNT18 CSGALNACT2	6.50e-04	35	97	3	GO:0008376
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	CACNA1E DNAH2 DNAH14 DNAH1 TACR2 DNAH5 DNAH9	4.32e-05	210	92	7	GO:0060294
GeneOntologyBiologicalProcess	cilium-dependent cell motility	CACNA1E DNAH2 DNAH14 DNAH1 TACR2 DNAH5 DNAH9	5.02e-05	215	92	7	GO:0060285
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	CACNA1E DNAH2 DNAH14 DNAH1 TACR2 DNAH5 DNAH9	5.02e-05	215	92	7	GO:0001539
GeneOntologyCellularComponent	dynein complex	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	4.16e-06	54	93	5	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH2 DNAH1 DNAH5 DNAH9	4.32e-06	25	93	4	GO:0005858
GeneOntologyCellularComponent	9+2 motile cilium	DNAH2 DNAH14 DNAH1 AKAP9 TACR2 DNAH5 DNAH9	9.37e-05	238	93	7	GO:0097729
GeneOntologyCellularComponent	microtubule associated complex	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	7.67e-04	161	93	5	GO:0005875
GeneOntologyCellularComponent	inner dynein arm	DNAH2 DNAH1	8.61e-04	10	93	2	GO:0036156
GeneOntologyCellularComponent	motile cilium	DNAH2 DNAH14 DNAH1 AKAP9 TACR2 DNAH5 DNAH9	1.04e-03	355	93	7	GO:0031514
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DNAH9	1.26e-03	12	93	2	GO:0036157
MousePheno	total anomalous pulmonary venous connection	CFC1 CFC1B DNAH5	5.00e-07	4	71	3	MP:0010441
MousePheno	superior-inferior ventricles	CFC1 CFC1B DNAH5	4.33e-06	7	71	3	MP:0011254
MousePheno	total anomalous pulmonary venous connection, intracardiac	CFC1 CFC1B	2.54e-05	2	71	2	MP:0010443
MousePheno	heart right ventricle hypoplasia	CFC1 CFC1B DNAH5	4.39e-05	14	71	3	MP:0010422
MousePheno	anomalous pulmonary venous connection	CFC1 CFC1B DNAH5	5.47e-05	15	71	3	MP:0010440
MousePheno	atrial septal defect	RYR1 SH3PXD2A CFC1 CFC1B DNAH5	8.28e-05	88	71	5	MP:0010403
MousePheno	transposition of great arteries	SH3PXD2A CFC1 CFC1B DNAH5	9.24e-05	47	71	4	MP:0004110
MousePheno	abnormal azygos vein morphology	SH3PXD2A CFC1 CFC1B	1.35e-04	20	71	3	MP:0011569
MousePheno	mesocardia	CFC1 CFC1B DNAH5	1.35e-04	20	71	3	MP:0000650
MousePheno	unbalanced complete common atrioventricular canal	CFC1 CFC1B	1.52e-04	4	71	2	MP:0011673
MousePheno	abnormal lung position or orientation	SH3PXD2A CFC1 CFC1B DNAH5	1.97e-04	57	71	4	MP:0010853
MousePheno	abnormal interatrial septum morphology	RYR1 SH3PXD2A CFC1 CFC1B DNAH5	2.08e-04	107	71	5	MP:0000282
MousePheno	common atrium	CFC1 CFC1B DNAH5	2.35e-04	24	71	3	MP:0010406
MousePheno	decreased heart right ventricle size	CFC1 CFC1B DNAH5	2.67e-04	25	71	3	MP:0003649
MousePheno	complete atrioventricular septal defect	CFC1 CFC1B DNAH5	3.00e-04	26	71	3	MP:0010413
MousePheno	abnormal inferior vena cava morphology	SH3PXD2A CFC1 CFC1B DNAH5	3.89e-04	68	71	4	MP:0006063
MousePheno	absent spleen	CFC1 CFC1B DNAH5	4.17e-04	29	71	3	MP:0000690
MousePheno	right-sided isomerism	CFC1 CFC1B DNAH5	4.62e-04	30	71	3	MP:0000508
MousePheno	right-sided stomach	CFC1 CFC1B DNAH5	5.10e-04	31	71	3	MP:0010808
MousePheno	abnormal heart position or orientation	SH3PXD2A CFC1 CFC1B DNAH5	5.38e-04	74	71	4	MP:0006065
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	5.60e-09	14	94	5	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	5.60e-09	14	94	5	IPR024743
Domain	MT	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	5.60e-09	14	94	5	PF12777
Domain	AAA_8	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	5.60e-09	14	94	5	PF12780
Domain	DHC_fam	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	8.37e-09	15	94	5	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	8.37e-09	15	94	5	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	8.37e-09	15	94	5	PF03028
Domain	Dynein_heavy_dom-2	DNAH2 DNAH1 DNAH5 DNAH9	5.79e-07	14	94	4	IPR013602
Domain	DHC_N2	DNAH2 DNAH1 DNAH5 DNAH9	5.79e-07	14	94	4	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH1 DNAH5 DNAH9	5.79e-07	14	94	4	IPR011704
Domain	AAA_5	DNAH2 DNAH1 DNAH5 DNAH9	5.79e-07	14	94	4	PF07728
Domain	DHC_N1	DNAH2 DNAH5 DNAH9	6.79e-06	8	94	3	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DNAH5 DNAH9	6.79e-06	8	94	3	IPR013594
Domain	CFC	CFC1 CFC1B	7.49e-05	3	94	2	PF09443
Domain	LETM1_RBD	LETM2 LETM1	7.49e-05	3	94	2	IPR033122
Domain	LETM1	LETM2 LETM1	7.49e-05	3	94	2	IPR011685
Domain	Cryptic/Cripto_CFC-dom	CFC1 CFC1B	7.49e-05	3	94	2	IPR019011
Domain	LETM1_RBD	LETM2 LETM1	7.49e-05	3	94	2	PS51758
Domain	LETM1	LETM2 LETM1	7.49e-05	3	94	2	PF07766
Domain	P-loop_NTPase	ABCA4 SETX MYO9B DHX38 DNAH2 IQCN RAB40A DNAH14 DNAH1 DNAH5 DNAH9 NLRP5	1.11e-03	848	94	12	IPR027417
Domain	Sulfatase_CS	ARSI ARSD	2.87e-03	16	94	2	IPR024607
Domain	SULFATASE_1	ARSI ARSD	3.24e-03	17	94	2	PS00523
Domain	SULFATASE_2	ARSI ARSD	3.24e-03	17	94	2	PS00149
Domain	Sulfatase	ARSI ARSD	3.64e-03	18	94	2	PF00884
Domain	Sulfatase_N	ARSI ARSD	3.64e-03	18	94	2	IPR000917
Domain	RNaseH-like_dom	EXD2 ISG20L2 ZMYM6	5.09e-03	69	94	3	IPR012337
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	CAMK1D SIK1 PSKH2	5.09e-03	69	94	3	IPR020636
Domain	AAA+_ATPase	ABCA4 DNAH2 DNAH5 DNAH9	6.05e-03	144	94	4	IPR003593
Domain	AAA	ABCA4 DNAH2 DNAH5 DNAH9	6.05e-03	144	94	4	SM00382
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH2 DNAH1 DNAH5 DNAH9	7.53e-06	27	67	4	M47755
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH2 DNAH1 DNAH5 DNAH9	5.00e-05	43	67	4	M47669
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH2 DNAH1 DNAH5 DNAH9	6.00e-05	45	67	4	M47670
Pathway	REACTOME_CARDIAC_CONDUCTION	NPR1 RYR1 AKAP9 KCNJ14 KCNQ1	1.27e-04	103	67	5	MM15196
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	2.24e-07	47	98	5	8812413
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH2 DNAH1 DNAH5	7.53e-07	7	98	3	9256245
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH2 DNAH5 DNAH9	7.53e-07	7	98	3	31178125
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH2 DNAH1 DNAH5	7.72e-06	14	98	3	9373155
Pubmed	Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel.	AKAP9 KCNQ1	7.86e-06	2	98	2	16002409
Pubmed	Mutation of an A-kinase-anchoring protein causes long-QT syndrome.	AKAP9 KCNQ1	7.86e-06	2	98	2	18093912
Pubmed	The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.	CFC1 CFC1B	7.86e-06	2	98	2	11174844
Pubmed	Identification of differentially expressed genes in mouse development using differential display and in situ hybridization.	CFC1 CFC1B	7.86e-06	2	98	2	11327798
Pubmed	Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis.	CFC1 CFC1B	7.86e-06	2	98	2	11024280
Pubmed	A mutation in the cardiac KV7.1 channel possibly disrupts interaction with Yotiao protein.	AKAP9 KCNQ1	7.86e-06	2	98	2	38657442
Pubmed	Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.	CFC1 CFC1B	7.86e-06	2	98	2	11062482
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	SETX DNAH1 AKAP9	1.18e-05	16	98	3	29878059
Pubmed	A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction.	AKAP9 KCNQ1	2.35e-05	3	98	2	24713462
Pubmed	Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.	CFC1 CFC1B	2.35e-05	3	98	2	16835440
Pubmed	Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia.	DNAH5 DNAH9	2.35e-05	3	98	2	15750039
Pubmed	MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.	TFEB RETREG1	2.35e-05	3	98	2	32716134
Pubmed	Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.	DNAH5 DNAH9	2.35e-05	3	98	2	15845866
Pubmed	Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.	LETM2 LETM1	2.35e-05	3	98	2	18628306
Pubmed	R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.	SETX APTX	4.70e-05	4	98	2	24637776
Pubmed	Cripto in tumors and embryo development.	CFC1 CFC1B	4.70e-05	4	98	2	11825688
Pubmed	The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.	AKAP9 KCNQ1	4.70e-05	4	98	2	19218243
Pubmed	Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.	DNAH1 DNAH5	4.70e-05	4	98	2	18492703
Pubmed	Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1.	CFC1 CFC1B	4.70e-05	4	98	2	9576836
Pubmed	DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.	DNAH5 DNAH9	4.70e-05	4	98	2	18950741
Pubmed	Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.	GRIN2C NRXN2	4.70e-05	4	98	2	35385735
Pubmed	Role of the EGF-CFC gene cripto in cell differentiation and embryo development.	CFC1 CFC1B	4.70e-05	4	98	2	11992720
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETX PARP2 APTX DHX38 RPSA CDC42BPB NDUFS4 SHKBP1 AP1G1 MRPS17 EXD2 KCTD3 TMED9 ISG20L2	7.80e-05	1497	98	14	31527615
Pubmed	DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.	DNAH5 DNAH9	7.82e-05	5	98	2	26909801
Pubmed	A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.	CFC1 CFC1B	7.82e-05	5	98	2	9053319
Pubmed	ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.	DNAH5 DNAH9	7.82e-05	5	98	2	23849778
Pubmed	Rab40b and Tks5 interact at invadopodia during metastasis.	RAB40A SH3PXD2A	7.82e-05	5	98	2	27909076
Pubmed	Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.	CFC1 CFC1B	7.82e-05	5	98	2	25224222
Pubmed	The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse.	DNAH5 DNAH9	7.82e-05	5	98	2	23525783
Pubmed	Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.	CAMK1D GALNT18 RYR1	8.33e-05	30	98	3	20080650
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	DNAH5 DNAH9	1.17e-04	6	98	2	33347437
Pubmed	A role of the cryptic gene in the correct establishment of the left-right axis.	CFC1 CFC1B	1.17e-04	6	98	2	10574770
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1E NRXN2	1.17e-04	6	98	2	12827191
Pubmed	Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.	CFC1 CFC1B	1.17e-04	6	98	2	12052855
Pubmed	GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.	CFC1 CFC1B	1.17e-04	6	98	2	17991893
Pubmed	Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy.	AP1G1 RETREG1	1.17e-04	6	98	2	19838196
Pubmed	Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.	AKAP9 KCNQ1	1.64e-04	7	98	2	11799244
Pubmed	Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis.	CYP2D6 UGT1A3	1.64e-04	7	98	2	19891553
Pubmed	Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice.	CFB FCGR1BP	1.64e-04	7	98	2	12794146
Pubmed	RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling.	SPSB1 ATRIP	1.64e-04	7	98	2	25916848
Pubmed	Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.	CFC1 CFC1B	1.64e-04	7	98	2	10521397
Pubmed	Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.	CFC1 CFC1B	1.64e-04	7	98	2	19906859
Pubmed	Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.	CFC1 CFC1B	2.18e-04	8	98	2	21419113
Pubmed	CFAP43 modulates ciliary beating in mouse and Xenopus.	DNAH1 DNAH9	2.18e-04	8	98	2	31884020
Pubmed	Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.	CFC1 CFC1B	2.18e-04	8	98	2	15736223
Pubmed	Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.	CAMK1D KCNQ1	2.79e-04	9	98	2	22923468
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	DNAH5 DNAH9	2.79e-04	9	98	2	27353389
Pubmed	Left-right patterning of the mouse lateral plate requires nodal produced in the node.	CFC1 CFC1B	2.79e-04	9	98	2	12654299
Pubmed	Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic.	CFC1 CFC1B	2.79e-04	9	98	2	18773496
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	DNAH2 DNAH1	3.48e-04	10	98	2	19825938
Pubmed	Transcription is required for establishment of germline methylation marks at imprinted genes.	CHST8 KCNQ1	3.48e-04	10	98	2	19136628
Pubmed	Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.	CFC1 CFC1B	3.48e-04	10	98	2	17913787
Pubmed	Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.	CYP2D6 KCNQ1	3.48e-04	10	98	2	21063774
Pubmed	Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.	CFC1 CFC1B	4.25e-04	11	98	2	15475956
Pubmed	Reprogramming tumour-associated macrophages to outcompete cancer cells.	TFEB FCGR1BP	4.25e-04	11	98	2	37380769
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	GRIN2C NRXN2	4.25e-04	11	98	2	9647694
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	SPSB1 RIPK2 SPICE1 AKAP9 PRMT2 KLHDC4	4.26e-04	342	98	6	23455924
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	CAMK1D GPR182 MROH5 SIK1 GALNT18 ISG20L2	5.66e-04	361	98	6	18976975
Pubmed	Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.	DNAH5 DNAH9	6.01e-04	13	98	2	35942101
Pubmed	Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function.	GRIN2C CRYBB2	6.01e-04	13	98	2	24096375
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	CFC1 CFC1B	6.01e-04	13	98	2	18550712
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KLHL35 RAB40A SHKBP1 KCTD3	6.42e-04	138	98	4	28786561
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1E P2RX6 KCNJ14 KCNQ1	6.60e-04	139	98	4	16985003
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	ABCA4 CFB	7.00e-04	14	98	2	19015224
Pubmed	Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.	CFC1 CFC1B	7.00e-04	14	98	2	17210915
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	CACNA1E RYR1 KCNJ14 KCNQ1	7.34e-04	143	98	4	20424473
Pubmed	Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.	SPSB1 GALNT18	8.06e-04	15	98	2	22491018
Pubmed	STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.	RIPK2 RETREG1	8.06e-04	15	98	2	29056340
Pubmed	Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.	CFC1 CFC1B	8.06e-04	15	98	2	12361961
Pubmed	Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.	CFC1 CFC1B	8.06e-04	15	98	2	24780629
Pubmed	Maternal Cripto is critical for proper development of the mouse placenta and the placental vasculature.	CFC1 CFC1B	8.06e-04	15	98	2	33730615
Pubmed	Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.	CFC1 CFC1B	8.06e-04	15	98	2	17360443
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SPSB1 B3GALNT2 IQCN CDC42BPB GALNT18 DNAH14 DNAH1 SHKBP1 GRTP1 SH3PXD2A TMEM143 PRORP	9.83e-04	1489	98	12	28611215
Pubmed	Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.	CFC1 CFC1B	1.04e-03	17	98	2	18697220
Pubmed	Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.	CAMK1D KCNQ1	1.04e-03	17	98	2	19741467
Pubmed	Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.	CFC1 CFC1B	1.04e-03	17	98	2	19716815
Pubmed	Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.	CFC1 CFC1B	1.04e-03	17	98	2	22627279
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 TFEB CTC1 MYO9B RPSA PLEKHG5 CDC42BPB RYR1 GRTP1 SLC45A3	1.13e-03	1105	98	10	35748872
Pubmed	A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.	MON2 RIPK2 CDC37 KCNQ1	1.17e-03	162	98	4	14743216
Pubmed	Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.	CFC1 CFC1B	1.17e-03	18	98	2	17936261
Pubmed	Tcf3: a transcriptional regulator of axis induction in the early embryo.	CFC1 CFC1B	1.17e-03	18	98	2	14668413
Pubmed	Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.	CFC1 CFC1B	1.17e-03	18	98	2	20346354
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	APTX IQCN PLEKHG5 DNAH14 SHKBP1 CDC37 EXD2 C8orf82 SENP7	1.22e-03	925	98	9	28986522
Pubmed	Long QT Syndrome Overview	AKAP9 KCNQ1	1.30e-03	19	98	2	20301308
Pubmed	Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic.	CFC1 CFC1B	1.30e-03	19	98	2	28126904
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	DNAH2 NDUFS4 LCLAT1 FOXRED2 AP1G1 EXD2 TMED9 TMEM143 KLHDC4	1.38e-03	942	98	9	31073040
Pubmed	Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.	CFC1 CFC1B	1.44e-03	20	98	2	11517919
Pubmed	Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.	CAMK1D KCNQ1	1.44e-03	20	98	2	19933996
Pubmed	Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.	CFC1 CFC1B	1.44e-03	20	98	2	11440720
Pubmed	A genome annotation-driven approach to cloning the human ORFeome.	CYP2D6 GNB1L CRYBB2 FOXRED2 P2RX6	1.49e-03	294	98	5	15461802
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	CFC1 CFC1B	1.59e-03	21	98	2	16291790
Pubmed	Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.	CFC1 CFC1B	1.75e-03	22	98	2	18241853
Pubmed	Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.	SHKBP1 KCTD3	1.75e-03	22	98	2	35952650
Pubmed	Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.	CFC1 CFC1B	1.91e-03	23	98	2	14623818
Pubmed	14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.	RIPK2 CDC42BPB SPICE1 KCTD3	1.93e-03	186	98	4	14744259
Pubmed	Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.	CFC1 CFC1B	2.08e-03	24	98	2	18171685
GeneFamily	Dyneins, axonemal	DNAH2 DNAH14 DNAH1 DNAH5 DNAH9	2.62e-09	17	63	5	536
GeneFamily	Beta 4-glycosyltransferases	CSGALNACT2 B4GALT4	1.57e-03	17	63	2	425
GeneFamily	Sulfatases	ARSI ARSD	1.76e-03	18	63	2	410
Coexpression	GSE17721_LPS_VS_POLYIC_6H_BMDC_DN	TFEB NPR1 CDC37 CRYBB2 RETREG1 PRMT2 KLHDC4	8.81e-06	199	96	7	M3809
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CACNA1E SPSB1 GNB1L CHST8 SPATA21 KCTD3 PRORP	2.59e-08	141	97	7	7ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E DNAH2 RYR1 DNAH9 IQCM NLRP5	1.79e-06	167	97	6	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	droplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR182 GNB1L PLEKHG5 NRXN2 SLC45A3 PDE7B	3.23e-06	185	97	6	6a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCell	droplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR182 GNB1L PLEKHG5 NRXN2 SLC45A3 PDE7B	3.23e-06	185	97	6	64791056cdbb739136dbef08f4b16e2b5427faad
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DNAH1 P2RX6 DNAH5 DNAH9	2.20e-05	154	97	5	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DNAH1 P2RX6 DNAH5 DNAH9	2.20e-05	154	97	5	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DNAH1 P2RX6 DNAH5 DNAH9	2.27e-05	155	97	5	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DNAH1 P2RX6 DNAH5 DNAH9	2.27e-05	155	97	5	0944429459f642a1bcc56edc1ec28aaecde3e2dc
Disease	Situs ambiguus	CFC1 DNAH5 DNAH9	1.22e-05	15	90	3	C0266642
Disease	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1	SETX APTX	2.75e-05	3	90	2	C1853761
Disease	double outlet right ventricle (implicated_via_orthology)	CFC1 CFC1B	2.75e-05	3	90	2	DOID:6406 (implicated_via_orthology)
Disease	Wolf-Hirschhorn syndrome (implicated_via_orthology)	LETM2 LETM1	5.50e-05	4	90	2	DOID:0050460 (implicated_via_orthology)
Disease	dextro-looped transposition of the great arteries (implicated_via_orthology)	CFC1 CFC1B	5.50e-05	4	90	2	DOID:0060770 (implicated_via_orthology)
Disease	right atrial isomerism (implicated_via_orthology)	CFC1 CFC1B	5.50e-05	4	90	2	DOID:0060856 (implicated_via_orthology)
Disease	mitochondrial metabolism disease (implicated_via_orthology)	LETM2 LETM1 NDUFS4	1.67e-04	35	90	3	DOID:700 (implicated_via_orthology)
Disease	visceral heterotaxy (implicated_via_orthology)	CFC1 CFC1B DNAH5	1.98e-04	37	90	3	DOID:0050545 (implicated_via_orthology)
Disease	Situs ambiguous	CFC1 DNAH9	3.27e-04	9	90	2	C1167664
Disease	Primary Ciliary Dyskinesia	DNAH1 DNAH5 DNAH9	4.04e-04	47	90	3	C4551720
Disease	Congenital long QT syndrome	AKAP9 KCNQ1	4.97e-04	11	90	2	cv:C1141890
Disease	Long QT syndrome	AKAP9 KCNQ1	5.95e-04	12	90	2	cv:C0023976
Disease	visceral heterotaxy (is_implicated_in)	CFC1 CFC1B	5.95e-04	12	90	2	DOID:0050545 (is_implicated_in)
Disease	quinate measurement	CFB KCNQ1	9.41e-04	15	90	2	EFO_0021167
Disease	Romano-Ward Syndrome	AKAP9 KCNQ1	1.07e-03	16	90	2	C0035828
Disease	Age-related macular degeneration	ABCA4 CFB	1.36e-03	18	90	2	cv:C0242383
Disease	amblyopia	CACNA1E CAMK1D	2.04e-03	22	90	2	MONDO_0001020
Disease	Dystonia	CACNA1E CYP2D6 APTX	2.34e-03	86	90	3	C0013421
Disease	atrophic macular degeneration	CFB NLRP5	2.64e-03	25	90	2	EFO_1001492
Disease	urate measurement, bone density	GRIN2C GALNT18 DNAH14 CFB DNAH1 FCGR1BP DNAH9	2.88e-03	619	90	7	EFO_0003923, EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLSMREVLRELHARG	UGT1A3	41	P35503
SRMKFLVRRWHRVTG	AKAP9	3776	Q99996
LVRRWHRVTGSVSIN	AKAP9	3781	Q99996
GSVVLQRNPVWRRHM	PRMT2	391	P55345
VRRWNCILMRNHDVT	ARSD	251	P51689
HPQVQSVRRIRDMQW	CRYBB2	181	P43320
SVRRIRDMQWHQRGA	CRYBB2	186	P43320
SVTWLGDRVMNLQHR	ERVK13-1	356	Q9NX77
HRILLVRAREGMWIP	ERVK-18	311	O42043
SHVRWQGRRLALTMD	C8orf82	191	Q6P1X6
LRVSKIRGQRQHVWM	CTC1	286	Q2NKJ3
RRHHMSVWEQRTSQL	CACNA1E	771	Q15878
RRMLWNVIVSIIREG	ABCA4	2106	P78363
RMKLLHQVSRVWRTD	B4GALT4	301	O60513
RKQRTSRALMHITDW	ARSI	336	Q5FYB1
MRVCWLVRQDSRHQR	APTX	16	Q7Z2E3
VYRWMVDSRVALRIH	BTBD11	216	A6QL63
MTWRHHVRLLFTVSL	CFC1B	1	P0CG36
ALHRRLGWERQALML	NPR1	171	P16066
MTWRHHVRLLFTVSL	CFC1	1	P0CG37
ARIVLLRHRMNWLGR	RAB40A	171	Q8WXH6
IRMVTVMQAHVRGWL	IQCM	291	A0A1B0GVH7
VMQAHVRGWLERKRL	IQCM	296	A0A1B0GVH7
LARRRIRLWHRGAMV	IQCN	941	Q9H0B3
RMSNWVGILSHGLRI	PARP2	431	Q9UGN5
RWHIDTIMRVLTTAG	AP1G1	416	O43747
GWNRTRHVIILMTDG	CFB	376	P00751
HRGWLLLQVSSRVFM	FCGR1BP	101	Q92637
LRMLHVDRQGGTWRL	KCNQ1	236	P51787
VAARMVWRLLHGQVL	LETM2	146	Q2VYF4
RHMWSKRNLRIVESP	PSKH2	366	Q96QS6
RIRVFHWRTMQPLAV	GNB1L	276	Q9BYB4
WGLRARHETSKMRVL	MAGED4	576	Q96JG8
MLWRILNGHSLTRRE	LETM1	181	O95202
MHSRGREIVVLLNPW	LCLAT1	1	Q6UWP7
GLRSLMQLESRWRQH	EXD2	571	Q9NVH0
MKRIWIHRRGEATAR	FAM157A	166	C9JC47
VLENHHWRSTIGMLR	PDE7B	241	Q9NP56
HWRSTIGMLRESRLL	PDE7B	246	Q9NP56
RWHMVLLTRDARRTA	NRXN2	111	Q9P2S2
RTRWSGIRKQHMVNA	ISG20L2	226	Q9H9L3
VQHLWRIVMANRNLR	NLRP5	826	P59047
TGLVNMHRIEILWRP	MON2	801	Q7Z3U7
TMEWVQTIGLRRIRP	CDC42BPB	1491	Q9Y5S2
RMQGLVSTESLWQHR	FOXRED2	621	Q8IWF2
MWRVGNLRRSHLVEA	KCNJ14	216	Q9UNX9
LRNPGMRIRHWETLS	DNAH1	1101	Q9P2D7
MPRRGLILHTRTHWL	CSGALNACT2	1	Q8N6G5
ASLFRWRHQARVERM	CDC37	26	Q16543
FLLLVDLMHRRQRWA	CYP2D6	16	P10635
RNNHELRNVIRSTWM	B3GALNT2	61	Q8NCR0
LRNVIRSTWMRHLLQ	B3GALNT2	66	Q8NCR0
LEHRARVWMVLSGAQ	GRTP1	71	Q5TC63
AHVRRNALRVAEVWM	GALNT18	396	Q6P9A2
RNIRALLSTMHTVLW	DNAJC6	831	O75061
RQAHKWIRQMEGSRL	DNAH14	2531	Q0VDD8
GRSGHRMVAWKRQLI	KLHDC4	176	Q8TBB5
IRERHWRQLMQATGV	DNAH9	1381	Q9NYC9
VVRALTVMLHRQWLT	ATRIP	686	Q8WXE1
TVMLHRQWLTVRRAG	ATRIP	691	Q8WXE1
LVQRLETSMIHWTRQ	DNAH2	241	Q9P225
LVLAAITSHMRSRRW	S1PR4	66	O95977
PRSLQELVSHMVVRW	RYR1	2091	P21817
NNHVRTWTVTRFRGM	KCTD3	441	Q9Y597
MSVVLRQTLWRRRAV	NDUFS4	6	O43181
NAIVIWIILAHRRMR	TACR2	51	P21452
WIILAHRRMRTVTNY	TACR2	56	P21452
GQAWVPTTHRRMISL	DPPA2	246	Q7Z7J5
MFRIGRRQLWKHSVT	DNAH5	1	Q8TE73
VMTRNWRVGALQRLL	P2RX6	31	O15547
RAHILPWVDNIVSRM	MROH5	391	Q6ZUA9
EVLRMRGTISREHPW	RPSA	181	P08865
HRGLVKMRIWGQRCR	RTP5	81	Q14D33
LSMAQRRHKRVRTWT	SENP7	826	Q9BQF6
HSRRLEMTNKQLWLR	TFEB	301	P19484
WRRMELLHQSSERTL	SPATA21	176	Q7Z572
RRMLNTHRTAVEQWH	SYT17	441	Q9BSW7
QRRTHVTMAISWITI	TMEM185B	206	Q9H7F4
MVLSRTRGAQLWRSL	RETREG1	136	Q9H6L5
GRRWQLMHERITPNR	SORCS3	326	Q9UPU3
QHRVRRAMCAGIWVL	GPR182	166	O15218
NHVRTWSVTRFRGMI	SHKBP1	451	Q8TBC3
VHPNEMVRRWAILTA	SETX	161	Q7Z333
RITIAQIRQHRWMRA	SIK1B	266	A0A0B4J2F2
RITIAQIRQHRWMRA	SIK1	266	P57059
MSVVRSSVHARWIVG	MRPS17	1	Q9Y2R5
LVLGRKHMLRRSSQW	PRORP	441	O15091
WRQAFNATAVVRHMR	CAMK1D	306	Q8IU85
MVQRLWVSRLLRHRK	SLC45A3	1	Q96JT2
ENRLFTQRWRVSHMG	SPICE1	596	Q8N0Z3
MLHVWQGVSERERRR	PNMA6A	181	P0CW24
WVSLHRSQQERKRVM	CHST8	146	Q9H2A9
RDRRAHYVMSIVIRW	C10orf67	6	Q8IYJ2
TLILVAIGVWQMRHL	TMED9	211	Q9BVK6
AQLHRRLWASVMAPV	PLEKHG5	391	O94827
HLSLRERMVEIGRRW	UBTFL6	251	P0CB48
MLHVTRGVWGSRVRV	TMEM143	16	Q96AN5
QITWAMRQRGTHAVV	SPSB1	101	Q96BD6
AHLRRLDRRWTLGGM	SH3PXD2A	246	Q5TCZ1
HRARMISLIESGWAQ	RIPK2	261	O43353
LFHTEMRWLSRGQIL	ZBED8	326	Q8IZ13
MRWLSRGQILTHIFE	ZBED8	331	Q8IZ13
RWETNRMLTSGVVHR	DHX38	376	Q92620
LHAEVRWISRGRMLK	ZMYM6	1066	O95789
MALLVDRVRGHWRIA	SLC35E3	1	Q7Z769
MRWVRHDAPARRGQL	KLHL35	221	Q6PF15
LLLQSWFRMVLERRH	MYO9B	961	Q13459
ILVRLRSHTVWERMS	MYOM2	156	P54296
PTMVVIALNRHRLWE	GRIN2C	356	Q14957