Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	clathrin adaptor activity	AP2A1 AP2A2	1.22e-03	22	47	2	GO:0035615
GeneOntologyMolecularFunction	cargo adaptor activity	AP2A1 AP2A2	1.57e-03	25	47	2	GO:0140312
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC11B ZDHHC11	1.70e-03	26	47	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC11B ZDHHC11	1.70e-03	26	47	2	GO:0019707
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC11B ZDHHC11	2.26e-03	30	47	2	GO:0016417
GeneOntologyCellularComponent	mitotic spindle pole	OR2A7 RMDN1 OR2A4	1.16e-04	43	46	3	GO:0097431
GeneOntologyCellularComponent	AP-2 adaptor complex	AP2A1 AP2A2	4.24e-04	14	46	2	GO:0030122
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	AP2A1 AP2A2	4.88e-04	15	46	2	GO:0030128
GeneOntologyCellularComponent	preribosome, small subunit precursor	NOC4L UTP20	4.88e-04	15	46	2	GO:0030688
GeneOntologyCellularComponent	mitotic spindle midzone	OR2A7 OR2A4	5.57e-04	16	46	2	GO:1990023
GeneOntologyCellularComponent	endosome	ADAM30 ATP10B ZDHHC11B OR2A7 SIGLEC1 AP2A1 AP2A2 ZDHHC11 OR2A4	8.65e-04	1167	46	9	GO:0005768
GeneOntologyCellularComponent	endolysosome membrane	AP2A1 AP2A2	8.78e-04	20	46	2	GO:0036020
GeneOntologyCellularComponent	clathrin coat of coated pit	AP2A1 AP2A2	9.69e-04	21	46	2	GO:0030132
GeneOntologyCellularComponent	mitotic spindle	OR2A7 CDC27 RMDN1 OR2A4	9.87e-04	201	46	4	GO:0072686
GeneOntologyCellularComponent	90S preribosome	NOC4L UTP20	1.85e-03	29	46	2	GO:0030686
GeneOntologyCellularComponent	endosome membrane	ADAM30 ATP10B ZDHHC11B AP2A1 AP2A2 ZDHHC11	1.96e-03	602	46	6	GO:0010008
GeneOntologyCellularComponent	endolysosome	AP2A1 AP2A2	1.98e-03	30	46	2	GO:0036019
GeneOntologyCellularComponent	clathrin adaptor complex	AP2A1 AP2A2	2.12e-03	31	46	2	GO:0030131
GeneOntologyCellularComponent	Flemming body	OR2A7 OR2A4	2.85e-03	36	46	2	GO:0090543
GeneOntologyCellularComponent	clathrin vesicle coat	AP2A1 AP2A2	3.17e-03	38	46	2	GO:0030125
GeneOntologyCellularComponent	spindle midzone	OR2A7 OR2A4	3.50e-03	40	46	2	GO:0051233
Domain	AP2_complex_asu	AP2A1 AP2A2	5.42e-06	2	44	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	5.42e-06	2	44	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	5.42e-06	2	44	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	5.42e-06	2	44	2	PF02296
Domain	-	AP2A1 AP2A2	5.42e-06	2	44	2	2.60.40.1030
Domain	-	AP2A1 AP2A2	3.24e-05	4	44	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	3.24e-05	4	44	2	IPR015873
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	1.51e-04	8	44	2	IPR009028
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	1.93e-04	9	44	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	1.93e-04	9	44	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	1.93e-04	9	44	2	SM00809
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	3.53e-04	12	44	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	5.59e-04	15	44	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	5.59e-04	15	44	2	PF01602
Domain	ARM-like	NOC4L UTP20 AP2A1 AP2A2	3.68e-03	270	44	4	IPR011989
Domain	ARM-type_fold	NOC4L UTP20 AP2A1 AP2A2	8.18e-03	339	44	4	IPR016024
Pathway	REACTOME_NEF_MEDIATED_CD8_DOWN_REGULATION	AP2A1 AP2A2	9.13e-05	7	30	2	M27044
Pathway	REACTOME_NEF_MEDIATED_CD4_DOWN_REGULATION	AP2A1 AP2A2	1.56e-04	9	30	2	M27011
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	2.38e-04	11	30	2	MM14694
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	2.85e-04	12	30	2	MM15163
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD2_FZD5_AND_ROR2	AP2A1 AP2A2	3.37e-04	13	30	2	M27415
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	3.92e-04	14	30	2	MM15161
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2A1 AP2A2	3.92e-04	14	30	2	M10122
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	AP2A1 AP2A2	4.52e-04	15	30	2	M27413
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	5.16e-04	16	30	2	M27761
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	AP2A1 AP2A2	5.16e-04	16	30	2	MM15048
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	AP2A1 AP2A2	5.16e-04	16	30	2	MM15506
Pathway	REACTOME_SIGNALING_BY_NTRKS	AP2A1 AP2A2 NTRK3	5.30e-04	75	30	3	MM14652
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	AP2A1 AP2A2	5.84e-04	17	30	2	M5488
Pathway	REACTOME_LDL_CLEARANCE	AP2A1 AP2A2	6.56e-04	18	30	2	MM15565
Pathway	REACTOME_LDL_CLEARANCE	AP2A1 AP2A2	7.32e-04	19	30	2	M27846
Pathway	REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS	AP2A1 AP2A2	8.97e-04	21	30	2	M12347
Pathway	REACTOME_THE_ROLE_OF_NEF_IN_HIV_1_REPLICATION_AND_DISEASE_PATHOGENESIS	AP2A1 AP2A2	1.60e-03	28	30	2	M11362
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	AP2A1 AP2A2	1.72e-03	29	30	2	MM15028
Pathway	WP_GABA_RECEPTOR_SIGNALING	AP2A1 AP2A2	1.96e-03	31	30	2	M39369
Pathway	REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS	AP2A1 AP2A2	1.96e-03	31	30	2	M7223
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	AP2A1 AP2A2	2.35e-03	34	30	2	MM15566
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	AP2A1 AP2A2	2.78e-03	37	30	2	M27847
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	AP2A1 AP2A2	2.78e-03	37	30	2	MM15102
Pathway	REACTOME_SIGNALING_BY_NTRKS	AP2A1 AP2A2 NTRK3	2.83e-03	134	30	3	M3574
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	AP2A1 AP2A2	2.93e-03	38	30	2	M39854
Pubmed	Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor.	AP2A1 AP2A2 NTRK3	8.33e-07	14	47	3	11157096
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	1.79e-06	2	47	2	28331227
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	1.79e-06	2	47	2	2564002
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	1.79e-06	2	47	2	12036598
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	1.79e-06	2	47	2	35384384
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	5.36e-06	3	47	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	5.36e-06	3	47	2	18032517
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	5.36e-06	3	47	2	22262466
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	5.36e-06	3	47	2	26269175
Pubmed	Identification of Tyrosine-Phosphorylated Proteins Upregulated during Epithelial-Mesenchymal Transition Induced with TGF-β.	TNS1 NTRK3	5.36e-06	3	47	2	26216473
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	5.36e-06	3	47	2	27315375
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	5.36e-06	3	47	2	8662627
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	5.36e-06	3	47	2	19129443
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	5.36e-06	3	47	2	34897408
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	5.36e-06	3	47	2	8617812
Pubmed	The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.	AP2A1 AP2A2	1.07e-05	4	47	2	12646615
Pubmed	Chk1-mediated phosphorylation of Cdh1 promotes the SCFβTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression.	CHEK1 CDC27	1.07e-05	4	47	2	32345958
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	1.07e-05	4	47	2	7683976
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	1.07e-05	4	47	2	29429998
Pubmed	Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.	AP2A1 AP2A2	1.07e-05	4	47	2	20500056
Pubmed	Association and colocalization of Eps15 with adaptor protein-2 and clathrin.	AP2A1 AP2A2	1.07e-05	4	47	2	9049247
Pubmed	Weak Molecular Interactions in Clathrin-Mediated Endocytosis.	AP2A1 AP2A2	1.78e-05	5	47	2	29184887
Pubmed	A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.	AP2A1 AP2A2	1.78e-05	5	47	2	17108326
Pubmed	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.	AP2A1 AP2A2	1.78e-05	5	47	2	16139856
Pubmed	Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.	AP2A1 AP2A2	1.78e-05	5	47	2	31671891
Pubmed	Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.	AP2A1 AP2A2	1.78e-05	5	47	2	15941406
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A1 AP2A2	1.78e-05	5	47	2	9723620
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP2A2	2.67e-05	6	47	2	22650988
Pubmed	The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.	AP2A1 AP2A2	2.67e-05	6	47	2	12121421
Pubmed	Clathrin.	AP2A1 AP2A2	2.67e-05	6	47	2	10966473
Pubmed	Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.	AP2A1 AP2A2	2.67e-05	6	47	2	22713487
Pubmed	Molecular architecture and functional model of the endocytic AP2 complex.	AP2A1 AP2A2	2.67e-05	6	47	2	12086608
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	2.67e-05	6	47	2	34490261
Pubmed	HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.	AP2A1 AP2A2	2.67e-05	6	47	2	15020715
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	AP2A1 AP2A2	3.74e-05	7	47	2	20351096
Pubmed	Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.	AP2A1 AP2A2	3.74e-05	7	47	2	16103193
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	AP2A1 AP2A2	3.74e-05	7	47	2	9280305
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	3.74e-05	7	47	2	23687301
Pubmed	Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.	AP2A1 AP2A2	3.74e-05	7	47	2	7671305
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	AP2A1 AP2A2	3.74e-05	7	47	2	23676497
Pubmed	Saturation mutagenesis defines novel mouse models of severe spine deformity.	OR2A7 OR2A4	4.98e-05	8	47	2	34142127
Pubmed	The small-subunit processome is a ribosome assembly intermediate.	NOC4L UTP20	4.98e-05	8	47	2	15590835
Pubmed	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.	AP2A1 AP2A2	4.98e-05	8	47	2	2014052
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	AP2A1 AP2A2	4.98e-05	8	47	2	11879655
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A1 AP2A2	6.40e-05	9	47	2	12057195
Pubmed	Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.	AP2A1 AP2A2	6.40e-05	9	47	2	11591131
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2A1 AP2A2	7.99e-05	10	47	2	25898166
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	AP2A1 AP2A2	7.99e-05	10	47	2	17581864
Pubmed	Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.	AP2A1 AP2A2	9.75e-05	11	47	2	31388001
Pubmed	HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization.	AP2A1 AP2A2	9.75e-05	11	47	2	19802344
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	ELL2 AP2A1 AP2A2 DDX39B	1.18e-04	186	47	4	33637726
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2A7 OR2A4	1.38e-04	13	47	2	11014824
Pubmed	Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.	AP2A1 AP2A2	1.38e-04	13	47	2	9882340
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	AP2A1 AP2A2	1.61e-04	14	47	2	30692166
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2A7 OR2A4	1.61e-04	14	47	2	7528109
Pubmed	APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.	AP2A1 AP2A2	1.61e-04	14	47	2	29262337
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	AP2A1 AP2A2	1.86e-04	15	47	2	21307259
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	AP2A1 AP2A2	2.12e-04	16	47	2	24305805
Pubmed	HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.	AP2A1 AP2A2	2.12e-04	16	47	2	21762802
Pubmed	PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.	AP2A1 AP2A2	2.12e-04	16	47	2	16055064
Pubmed	The frantic play of the concealed HIV envelope cytoplasmic tail.	AP2A1 AP2A2	2.70e-04	18	47	2	23705972
Pubmed	The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.	AP2A1 AP2A2	2.70e-04	18	47	2	10567358
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	AP2A1 AP2A2	2.70e-04	18	47	2	23211419
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	AP2A1 AP2A2	3.01e-04	19	47	2	31959764
Pubmed	Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.	MED17 CDC27	3.34e-04	20	47	2	36551904
Pubmed	Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.	AP2A1 AP2A2	4.06e-04	22	47	2	26950368
Pubmed	Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.	AP2A1 AP2A2	4.84e-04	24	47	2	20012524
Pubmed	Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.	AP2A1 AP2A2	5.26e-04	25	47	2	20594957
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CHSY1 AP2A1 AP2A2 NTRK3	5.66e-04	281	47	4	28706196
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	AP2A1 AP2A2	5.69e-04	26	47	2	24067654
Pubmed	The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.	AP2A1 AP2A2	5.69e-04	26	47	2	23077317
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TARS3 LRCH2 AP2A1 AP2A2 TNS1 DDX39B CACNA2D3 STRIP1	6.06e-04	1431	47	8	37142655
Pubmed	The AP-3 complex: a coat of many colours.	AP2A1 AP2A2	6.61e-04	28	47	2	9714600
Pubmed	The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.	AP2A1 AP2A2	7.09e-04	29	47	2	29665387
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	AP2A1 AP2A2	8.11e-04	31	47	2	22323290
Pubmed	Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.	NTRK3 CACNA2D3	8.11e-04	31	47	2	21300867
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MED17 AP2A1 AP2A2 CDC27 PCID2	9.34e-04	560	47	5	35241646
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GDPD1 NOC4L ZMYM1 AP2A1 AP2A2 PCID2 STRIP1	1.09e-03	1203	47	7	29180619
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	SIGLEC1 AP2A1 AP2A2	1.24e-03	156	47	3	30409884
Cytoband	5p15.33	ZDHHC11B ZDHHC11	4.99e-04	32	47	2	5p15.33
Cytoband	15q26.3	CHSY1 TARS3	8.20e-04	41	47	2	15q26.3
Cytoband	7q35	OR2A25 OR2A7	1.47e-03	55	47	2	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	OR2A25 OR2A7	2.11e-03	66	47	2	chr7q35
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	7.18e-04	24	30	2	76
GeneFamily	Olfactory receptors, family 2	OR2A25 OR2A7 OR2A4	8.53e-04	113	30	3	149
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDPD1 ZMYM1 AP2A1 CADPS2	2.75e-05	165	47	4	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	facs-Skin-nan-18m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP61 TEX11 SLC35F3 NTRK3	3.54e-05	176	47	4	086197acbfec4ac0c15b7e9721871aaa9e32e219
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	SIGLEC1 CADPS2 FPR1 CACNA2D3	3.95e-05	181	47	4	921e917f83105896ad8918dc134b871708024021
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDPD1 ATP10B SIGLEC1 FPR1	3.95e-05	181	47	4	a93df1ba23d5b5f249491d69d12bfc0e274dafcf
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP61 SPAG16 SCIN ACSS3	4.03e-05	182	47	4	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP61 SPAG16 SCIN ACSS3	4.03e-05	182	47	4	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCRL2 SIGLEC1 SCIN FPR1	4.39e-05	186	47	4	e4de270d38bbed022f545bd0bbaa9599e707ec87
ToppCell	MS-mono3\|MS / Condition, Cell_class and T cell subcluster	CCRL2 ELL2 SCIN FPR1	4.58e-05	188	47	4	a50a766c2f02e776c8e5c6e0833ec241c61831c4
ToppCell	MS-mono3-\|MS / Condition, Cell_class and T cell subcluster	CCRL2 ELL2 SCIN FPR1	4.58e-05	188	47	4	e8c1c2941ca4919e0097a65b692b7af8018e8886
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CADPS2 SLC35F3 STXBP5L CACNA2D3	4.67e-05	189	47	4	a75226616340045b581d08429d2e123e041dee55
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ELL2 CADPS2 SCIN ACSS3	4.87e-05	191	47	4	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CADPS2 SLC35F3 STXBP5L CACNA2D3	4.97e-05	192	47	4	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	CCRL2 SIGLEC1 AP2A2 TNS1	5.17e-05	194	47	4	40dbfdf1d7e6b73d120d8f802f08e573fe9a739e
ToppCell	IIH-mono3-\|IIH / Condition, Cell_class and T cell subcluster	CCRL2 ELL2 SCIN FPR1	5.27e-05	195	47	4	28a858b04a7b413916c07a8d880f5ea02e985461
ToppCell	IIH-mono3\|IIH / Condition, Cell_class and T cell subcluster	CCRL2 ELL2 SCIN FPR1	5.27e-05	195	47	4	c6dd5af582d257be64b718e30f60220c1bf1738a
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL13 SIGLEC1 FPR1 CACNA2D3	5.38e-05	196	47	4	23e22dfb9f9aec17b83574295f889e75f46ded50
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CCL\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CCRL2 SIGLEC1 CEP295NL FPR1	5.71e-05	199	47	4	52c06fcc112da21b1d914a896c04bde06fc756fe
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-Plasmablast\|Leuk-UTI / Disease, condition lineage and cell class	SIAE CHEK1 ELL2 TNS1	5.71e-05	199	47	4	1b17e6d5e6b994dec65efae2667f4f1f438161b1
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	CCRL2 SIGLEC1 SCIN FPR1	5.71e-05	199	47	4	c55181bdec8952b54198f0d4c9c5c84265b16572
Disease	clostridium difficile infection	GDPD1 DDX39B PCID2	1.22e-03	144	43	3	EFO_0009130
Disease	invasive ductal carcinoma (is_marker_for)	IL13 NTRK3	1.56e-03	40	43	2	DOID:3008 (is_marker_for)
Disease	ocular hypertension, response to triamcinolone acetonide	GDPD1 CFAP61	2.34e-03	49	43	2	EFO_0006954, EFO_1001069
Disease	alopecia areata	IL13 FPR1	2.43e-03	50	43	2	EFO_0004192

Protein segments in the cluster

Peptide	Gene	Start	Entry
INRKLKKHLCLYLAL	CEP295NL	351	Q96MC4
CKLFGKLNIIYLLEK	CFAP61	36	Q8NHU2
NLLVVLILVKYKGLK	CCRL2	56	O00421
IHLLALKAYKKPELL	ELL2	211	O00472
FKRHFLKIKGKLIDI	CHEK1	451	O14757
KLTLHGLQQYYVKLK	DDX39B	256	Q13838
KKYVCKLLFIFLLGH	AP2A1	56	O95782
FAITRFKHLKKLLLV	ATP10B	1086	O94823
KKYVCKLLFIFLLGH	AP2A2	56	O94973
ITEYHLLKLLQKFGK	RBM18	36	Q96H35
NIKEIYKILHALGKA	NTRK3	816	Q16288
DLHFPLALYKKLLNV	HERC3	806	Q15034
AQFVKDLLLHLKKLF	IL13	126	P35225
FLLLKYPTLLHQRKK	GDPD1	21	Q8N9F7
GLLEKIIKQAKHIFL	MED17	426	Q9NVC6
PKEQKKYLLLFHSLF	OR2A7	266	Q96R45
PKEQKKYLLLFHSLF	OR2A4	266	O95047
FKKVYLLLKTHQLSL	PCID2	326	Q5JVF3
PVSYLLQLKGKKHVL	ADAM30	61	Q9UKF2
HLSQLEAIKLYLKGK	CACNA2D3	666	Q8IZS8
ILGIKKLEHQLLYNA	CADPS2	246	Q86UW7
GKLKKILYFHENQLI	GTDC1	81	Q4AE62
FLIGKVYKKLGQTHL	CDC27	741	P30260
KHKLPLSLYKKVLLI	NOC4L	261	Q9BVI4
LKGKVHIFKYLNIQA	LRCH2	291	Q5VUJ6
PKEQKKYLLLFHSLF	OR2A25	266	A4D2G3
LKKDHQLLLAIYGKK	TARS3	141	A2RTX5
TKHLFLLLKDYAKLG	UTP20	2156	O75691
HLLSLFKDKPLIIYK	SCIN	481	Q9Y6U3
ALLYLKHKVKFGNAV	OVCH1	141	Q7RTY7
YGLIATKIHKQGLIK	FPR1	221	P21462
VLLLLLKHFKLNHVY	STRIP1	581	Q5VSL9
LQDKVHLLKLLLFYA	SIMC1	841	Q8NDZ2
KIELLAHKGLLNLTY	SIAE	411	Q9HAT2
ALYKVLFKLLLGSAK	SLC35F3	246	Q8IY50
ILVLYSIGVKHKKQG	STXBP5L	426	Q9Y2K9
ALKIGQHKPDKILIY	ACSS3	241	Q9H6R3
EYILDLLLLYKKHKG	CHSY1	446	Q86X52
KNLLLLGKTYLKLHN	RMDN1	261	Q96DB5
LGKTYLKLHNKKLAA	RMDN1	266	Q96DB5
KNKLINDLKGLKLHY	SPAG16	206	Q8N0X2
LLKGDILLKCYHKKF	TNS1	241	Q9HBL0
AHYPLIALKALKKAL	TEX11	786	Q8IYF3
HLQVKYAPKGVKILL	SIGLEC1	231	Q9BZZ2
LGQLLIFHIYLKAKK	ZDHHC11	251	Q9H8X9
KKYLKLIIENILFLG	ZMYM1	551	Q5SVZ6
LGQLLIFHIYLKAKK	ZDHHC11B	251	P0C7U3
KFWNGLKNLKLLYLH	LRRIQ3	91	A6PVS8