Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.82e-0735294GO:0015020
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor activity

TAF1 TAF4 FOXA2

5.80e-0552293GO:0016251
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.78e-05153294GO:0008194
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

TAF1 TAF4 FOXA2

1.30e-0468293GO:0140223
GeneOntologyMolecularFunctionhexosyltransferase activity

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.34e-04211294GO:0016758
GeneOntologyMolecularFunctionretinoic acid binding

UGT2B4 UGT2B7

7.52e-0428292GO:0001972
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.57e-04288294GO:0016757
GeneOntologyMolecularFunctionretinoid binding

UGT2B4 UGT2B7

2.20e-0348292GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT2B4 UGT2B7

2.30e-0349292GO:0019840
GeneOntologyBiologicalProcessbiphenyl catabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.53e-108304GO:0070980
GeneOntologyBiologicalProcessbiphenyl metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.59e-1010304GO:0018879
GeneOntologyBiologicalProcessxenobiotic glucuronidation

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.78e-0912304GO:0052697
GeneOntologyBiologicalProcesscellular glucuronidation

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.14e-0821304GO:0052695
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.32e-0826304GO:0019585
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.32e-0826304GO:0006063
GeneOntologyBiologicalProcessbenzene-containing compound metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.32e-0737304GO:0042537
GeneOntologyBiologicalProcessxenobiotic catabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.32e-0737304GO:0042178
GeneOntologyBiologicalProcessandrogen metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.59e-0738304GO:0008209
GeneOntologyBiologicalProcessestrogen metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

9.38e-0752304GO:0008210
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

UGT2B4 UGT2B7 UGT2B28 UGT2B11 RECQL5

1.58e-05222305GO:0071466
GeneOntologyBiologicalProcessregulation of hormone levels

UGT2B4 UGT2B7 UGT2B28 UGT2B11 FOXA2 CTSB BAIAP3

4.47e-05684307GO:0010817
GeneOntologyBiologicalProcessxenobiotic metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.99e-05141304GO:0006805
GeneOntologyBiologicalProcesshormone metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11 CTSB

5.31e-05286305GO:0042445
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

UGT2B4 UGT2B7 SCN11A UGT2B28 UGT2B11 RECQL5

9.33e-05525306GO:0009410
GeneOntologyBiologicalProcesssteroid metabolic process

UGT2B4 UGT2B7 UGT2B28 UGT2B11 FOXA2

1.92e-04376305GO:0008202
GeneOntologyCellularComponentnuclear outer membrane

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.04e-0740304GO:0005640
GeneOntologyCellularComponentorganelle outer membrane

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.47e-04279304GO:0031968
GeneOntologyCellularComponentouter membrane

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.65e-04281304GO:0019867
GeneOntologyCellularComponentMLL1 complex

TAF1 TAF4

9.61e-0432302GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

TAF1 TAF4

1.02e-0333302GO:0044665
GeneOntologyCellularComponentnuclear membrane

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.49e-03349304GO:0031965
GeneOntologyCellularComponentaxonal growth cone

SCN11A PALLD

1.90e-0345302GO:0044295
GeneOntologyCellularComponenttranscription factor TFIID complex

TAF1 TAF4

2.07e-0347302GO:0005669
DomainUDPGT

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.64e-0821314PS00375
DomainUDPGT

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.64e-0821314PF00201
DomainUDP_glucos_trans

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.64e-0821314IPR002213
Domain-

FOXA2 RECQL5 FOXD4 H1-2

4.44e-042183141.10.10.10
DomainWHTH_DNA-bd_dom

FOXA2 RECQL5 FOXD4 H1-2

6.57e-04242314IPR011991
DomainTF_fork_head_CS_2

FOXA2 FOXD4

2.64e-0346312IPR030456
DomainTF_fork_head_CS_1

FOXA2 FOXD4

2.75e-0347312IPR018122
DomainFORK_HEAD_3

FOXA2 FOXD4

2.99e-0349312PS50039
DomainFH

FOXA2 FOXD4

2.99e-0349312SM00339
DomainFORK_HEAD_1

FOXA2 FOXD4

2.99e-0349312PS00657
DomainFORK_HEAD_2

FOXA2 FOXD4

2.99e-0349312PS00658
DomainForkhead

FOXA2 FOXD4

2.99e-0349312PF00250
DomainFork_head_dom

FOXA2 FOXD4

2.99e-0349312IPR001766
DomainZF_DAG_PE_1

TNS2 CDC42BPA

5.04e-0364312PS00479
DomainZF_DAG_PE_2

TNS2 CDC42BPA

5.04e-0364312PS50081
DomainC1

TNS2 CDC42BPA

5.20e-0365312SM00109
DomainPE/DAG-bd

TNS2 CDC42BPA

5.35e-0366312IPR002219
DomainIon_trans_dom

SCN11A KCNB2

1.53e-02114312IPR005821
DomainIon_trans

SCN11A KCNB2

1.53e-02114312PF00520
PathwayREACTOME_PREDNISONE_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.67e-0823234MM16639
PathwayREACTOME_GLUCURONIDATION

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.60e-0824234MM14599
PathwayWP_GLUCURONIDATION

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.66e-0825234MM15820
PathwayREACTOME_GLUCURONIDATION

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.66e-0825234M17787
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.66e-0825234M605
PathwayWP_GLUCURONIDATION

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.86e-0826234M39404
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.07e-0728234M19580
PathwayREACTOME_PARACETAMOL_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.26e-0739234MM15695
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.24e-0741234M7399
PathwayREACTOME_ASPIRIN_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.00e-0744234M45014
PathwayREACTOME_ASPIRIN_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.67e-0745234MM15694
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.28e-0651234M17726
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.38e-0652234M14171
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.74e-0655234M14933
PathwayKEGG_RETINOL_METABOLISM

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.21e-0664234M9488
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.60e-0670234M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.15e-0672234M9257
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.49e-05107234MM14595
PathwayREACTOME_DRUG_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.67e-05109234M45012
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.67e-05109234M18788
PathwayREACTOME_DRUG_ADME

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.78e-05119234MM15692
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.01e-04183234M39588
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

UGT2B4 UGT2B7

2.29e-0414232M39328
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.98e-04219234MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.05e-04220234M10320
PathwayKEGG_BASAL_TRANSCRIPTION_FACTORS

TAF1 TAF4

1.47e-0335232M4864
PathwayREACTOME_HIV_TRANSCRIPTION_INITIATION

TAF1 TAF4

2.63e-0347232M29568
PathwayREACTOME_RNA_POLYMERASE_II_PROMOTER_ESCAPE

TAF1 TAF4

2.74e-0348232MM15424
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK10 NHS CDC42BPA

2.77e-03175233MM15599
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK10 NHS CDC42BPA

3.20e-03184233M41809
PathwayREACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME

TAF1 TAF4

5.75e-0370232M27008
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

TAF1 TAF4

7.63e-0381232M865
PathwayREACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS

TAF1 TAF4

8.00e-0383232MM15314
Pubmed

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.80e-11731426074487
Pubmed

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.60e-11831432093886
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.58e-076631419898482
Pubmed

Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.

UGT2B4 UGT2B7

7.69e-07231217263731
Pubmed

Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.

UGT2B4 UGT2B7

7.69e-07231210222050
Pubmed

Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.

UGT2B28 UGT2B11

7.69e-07231221679149
Pubmed

Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.

UGT2B4 UGT2B7

7.69e-07231215319348
Pubmed

Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.

UGT2B4 UGT2B7

2.31e-0633127835904
Pubmed

cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.

UGT2B4 UGT2B11

2.31e-0633128333863
Pubmed

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.

UGT2B4 UGT2B7

2.31e-06331222092298
Pubmed

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .

UGT2B4 UGT2B7

2.31e-06331229138287
Pubmed

Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol.

UGT2B4 UGT2B7

4.61e-06431216849011
Pubmed

UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients.

UGT2B4 UGT2B7

7.68e-06531215318931
Pubmed

Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.

TAF1 TAF4 FOXA2

7.72e-064331318722179
Pubmed

Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with traps in activator-induced transcription.

TAF1 TAF4

1.15e-05631211564872
Pubmed

Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.

TAF1 TAF4

1.15e-05631224289924
Pubmed

Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.

TAF1 TAF4

1.15e-0563128858156
Pubmed

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.

TAF1 TAF4 FOXA2

1.22e-055031327026076
Pubmed

Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer.

UGT2B7 UGT2B28

1.61e-05731220056642
Pubmed

Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

TAF1 TAF4

1.61e-0573127729427
Pubmed

Core promoter binding by histone-like TAF complexes.

TAF1 TAF4

2.15e-05831215601843
Pubmed

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.

UGT2B4 UGT2B7

2.15e-05831210748067
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT2B4 UGT2B7

2.15e-05831218052087
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXA2 FOXD4

2.15e-0583128530406
Pubmed

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

UGT2B4 UGT2B7

2.15e-05831218719240
Pubmed

Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.

UGT2B4 UGT2B7

2.15e-05831220142249
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

UGT2B4 UGT2B7 UGT2B11 NDUFV2

2.57e-0519331419343046
Pubmed

The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.

TAF1 TAF4

2.76e-05931212665565
Pubmed

CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues.

TAF1 TAF4

4.21e-05113129153318
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT2B4 UGT2B7

5.05e-051231220308471
Pubmed

Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.

UGT2B4 UGT2B7

5.05e-051231218161889
Pubmed

Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.

TAF1 TAF4

5.96e-051331211557891
Pubmed

Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.

TAF1 TAF4

5.96e-05133129311784
Pubmed

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

TAF1 TAF4

6.95e-051431227007846
Pubmed

Human TFIID binds to core promoter DNA in a reorganized structural state.

TAF1 TAF4

6.95e-051431223332750
Pubmed

The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.

TAF1 TAF4

8.02e-051531214580349
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXA2 FOXD4

8.02e-05153127689224
Pubmed

Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.

TAF1 TAF4

9.16e-05163128680883
Pubmed

Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.

TAF1 TAF4

9.16e-05163128764009
Pubmed

Direct interaction of human TFIID with the HIV-1 transactivator tat.

TAF1 TAF4

9.16e-05163128121496
Pubmed

A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.

TAF1 TAF4

9.16e-05163127836461
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXA2 FOXD4

9.16e-051631210208738
Pubmed

Novel mechanism and factor for regulation by HIV-1 Tat.

TAF1 TAF4

9.16e-05163127835343
Pubmed

Histone-like TAFs within the PCAF histone acetylase complex.

TAF1 TAF4

1.04e-04173129674425
Pubmed

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.

TAF1 TAF4

1.17e-041831229111974
Pubmed

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

UGT2B4 UGT2B7

1.17e-041831220056724
Pubmed

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.

TAF1 TAF4

1.17e-041831215053879
Pubmed

Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.

TAF1 TAF4

1.17e-04183127933101
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXA2 FOXD4

1.30e-04193129895322
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.

TAF1 TAF4

1.30e-04193128764062
Pubmed

Lost in transcription: molecular mechanisms that control HIV latency.

TAF1 TAF4

1.30e-041931223518577
Pubmed

Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.

TAF1 TAF4

1.45e-04203129603525
Pubmed

Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4.

TAF1 TAF4

1.45e-042031217884155
Pubmed

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

TAF1 TAF4

1.45e-042031217967894
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

MSL1 TAF1 TAF4 RECQL5 NDUFV2 H1-2

1.72e-0495431636373674
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXA2 FOXD4

1.76e-042231217389379
Pubmed

Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency.

TAF1 TAF4

2.10e-042431223827503
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXA2 FOXD4

2.10e-042431211820816
Pubmed

Identification of transcripts with enriched expression in the developing and adult pancreas.

UGT2B4 UGT2B7 UGT2B28 UGT2B11 FOXA2

2.11e-0462431518554416
Pubmed

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

TAF1 TAF4

2.28e-042531219240132
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXA2 FOXD4

2.47e-042631215857913
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

TAF1 TAF4

3.52e-043131215960975
Pubmed

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

TAF1 TAF4

3.99e-043331211564863
Pubmed

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

FOXA2 CTSB

4.24e-043431225915474
Pubmed

Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.

UGT2B4 UGT2B11

5.30e-043831220214802
Pubmed

Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.

TAF1 TAF4

5.58e-04393129054383
Pubmed

The general transcription factors of RNA polymerase II.

TAF1 TAF4

5.58e-04393128946909
Pubmed

Three transitions in the RNA polymerase II transcription complex during initiation.

TAF1 TAF4

5.58e-04393129405375
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

ERFE PALLD H1-2

5.87e-0418431332908313
Pubmed

Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.

TAF1 TAF4

5.87e-04403121939271
Pubmed

ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.

TAF1 TAF4

5.87e-04403122449431
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

MSL1 TAF1

6.79e-044331233472061
Pubmed

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

TAF1 TAF4

7.77e-04463128849451
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

TAF1 TAF4

7.77e-044631225209997
CytobandEnsembl 112 genes in cytogenetic band chr4q13

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.85e-06157314chr4q13
Cytoband4q13

UGT2B4 UGT2B7

4.61e-05153124q13
Cytoband4q13.2

UGT2B28 UGT2B11

2.03e-04313124q13.2
Cytoband16p13.3

BRICD5 BAIAP3

1.18e-0224431216p13.3
GeneFamilyUDP glucuronosyltransferases

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.78e-0832224363
GeneFamilyForkhead boxes

FOXA2 FOXD4

1.24e-0343222508
CoexpressionWENG_POR_TARGETS_LIVER_UP

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.50e-0753314MM1203
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP

UGT2B4 DOCK10 UGT2B7 UGT2B28 UGT2B11 PALLD

6.28e-07267316MM984
CoexpressionVANLOO_SP3_TARGETS_DN

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.52e-06103314MM919
CoexpressionSERVITJA_ISLET_HNF1A_TARGETS_DN

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.23e-05121314MM935
CoexpressionSERVITJA_LIVER_HNF1A_TARGETS_DN

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.22e-05190314MM1311
CoexpressionOHGUCHI_LIVER_HNF4A_TARGETS_DN

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.98e-05201314MM1294
CoexpressionABDULRAHMAN_KIDNEY_CANCER_VHL_DN

UGT2B7 PALLD

1.05e-0413312M2096
CoexpressionYAMASHITA_LIVER_CANCER_WITH_EPCAM_DN

UGT2B7 UGT2B11

1.82e-0417312M9914
CoexpressionBOCHKIS_FOXA2_TARGETS

UGT2B4 UGT2B7 UGT2B28 UGT2B11 FOXA2

2.04e-04467315MM1233
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD GPR17 SEMA3G CDC42BPA

8.87e-06190314f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

JCAD GPR17 SEMA3G CDC42BPA

9.05e-0619131450601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ComputationalGenes in the cancer module 227.

UGT2B4 UGT2B7

4.13e-0415222MODULE_227
ComputationalSteroid hormone and heme metabolism.

UGT2B4 UGT2B7

4.72e-0416222MODULE_505
DrugC1 11-32

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.49e-0918314CID000443077
DrugC11131

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.49e-0918314CID000443076
DrugT4-G

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.07e-0819314CID000152424
Drugestriol-16-glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.66e-0821314CID000122281
Drug3-OHBaP

UGT2B4 UGT2B7 UGT2B28 UGT2B11 BAIAP3

2.22e-0863315CID000025890
Drugestradiol-3-glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.44e-0823314CID000066651
DrugL-idaro-1,4-lactone

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.63e-0828314CID000078997
Drug7-hydroxycoumarin glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.52e-0829314CID000125641
DrugAC1Q6OQG

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.12e-0733314CID000009686
DrugBP-3,6-quinol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.12e-0733314CID000119292
DrugAC1NOWCJ

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.43e-0735314CID005120112
Drug3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.43e-0735314CID010436171
Drugestrone-3-glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.43e-0735314CID000115255
Drugl-borneol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.80e-0737314CID000010049
Drugharmol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.48e-0740314CID000068094
Drugtestosterone glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.75e-0741314CID000108192
Drug2-AF

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.75e-0741314CID000005800
Drugandrosterone glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.34e-0743314CID000114833
Drug7,8-benzoquinoline

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.34e-0743314CID000009191
DrugMS-222

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.67e-0744314CID000011400
Drugsalicylamide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.25e-0748314CID000005147
DrugAC1NQGK1

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.27e-0752314CID005195977
Drugoxazepam

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.86e-0753314CID000004616
Drug7-methoxycoumarin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.06e-0657314CID000010748
Drugphenolphthalein

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.13e-0658314CID000004764
Drugurochloralic acid

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-0659314CID003036914
Drug4-hydroxybiphenyl

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-0659314CID000007103
Drug4-hydroxyestrone

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-0659314CID000018418
Drugacetaminophen glucuronide

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-0659314CID000083944
DrugSN-38G

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-0659314CID000443154
DrugUDP-alpha-d-xylopyranose

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.30e-0660314CID000001165
Drug2-hydroxyestriol

UGT2B7 UGT2B11

1.79e-062312ctd:C008012
DrugMeldola

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.15e-0668314CID000081507
Drugmethoxyresorufin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.28e-0669314CID000119220
DrugAC1LCF1F

UGT2B4 UGT2B7 UGT2B28 UGT2B11 BAIAP3

2.43e-06161315CID000627275
Drug2,2,2-trichloroethanol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.87e-0673314CID000008259
Drugeugenol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.87e-0673314CID000003314
Drug7-hydroxycoumarin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.19e-0675314CID005281426
Drug16-epiestriol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.55e-0677314CID000003269
DrugAC1N8H7N

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.74e-0678314CID004318740
Drugbenzyloxyresorufin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.74e-0678314CID000114982
Drugacridine

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.35e-0681314CID000009215
DrugSN-38

UGT2B4 UGT2B7 UGT2B28 UGT2B11 H1-2

4.68e-06184315CID000104842
Drug5 alpha-androstane

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.03e-0684314CID000094144
DrugHymecromone

UGT2B4 UGT2B7 UGT2B11

5.15e-0625313ctd:D006923
DrugDNCB

UGT2B4 UGT2B7 UGT2B28 UGT2B11 CTSB

5.33e-06189315CID000000006
Drug5 alpha-dihydroaldosterone

UGT2B4 UGT2B7

5.38e-063312CID003036614
Drug7-ethoxycoumarin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.52e-0686314CID000035703
Drugmenthol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.78e-0687314CID000001254
Drugpentoxyresorufin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

5.78e-0687314CID000107683
DrugDiphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; PC3; HT_HG-U133A

SCN11A ZCWPW1 GPR17 SEMA3G CDC42BPA

6.52e-061973154299_UP
Drug4-aminobiphenyl

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.22e-0692314CID000007102
Drugp-nitroanisole

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.22e-0692314CID000007485
Drug2-naphthol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.54e-0693314CID000008663
DrugDCNB

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.21e-0695314CID000007443
Drugethoxyresorufin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.21e-0695314CID000003294
DrugDB04103

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.92e-0697314CID004469987
Drug1-naphthol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

9.29e-0698314CID000007005
Drug3-hydroxyandrostan-17-one

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.09e-05102314CID000000225
Drugchrysin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.27e-05106314CID005281607
Drugfluconazole

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.32e-05107314CID000003365
Drugbuthionine sulfoximine

UGT2B4 UGT2B7 UGT2B28 UGT2B11 BAIAP3

1.35e-05229315CID000021157
Drug2-naphthylamine

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.47e-05110314CID000007057
Drughyodeoxycholic acid

UGT2B4 UGT2B7

1.79e-055312ctd:C010471
DrugAmobarbital

UGT2B4 UGT2B7

1.79e-055312ctd:D000654
Drugphenolphthalin

UGT2B4 UGT2B7

1.79e-055312CID000066494
Druglithocholic acid

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.81e-05116314CID000009903
Drugethoxyquin

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.81e-05116314CID000003293
DrugAC1Q7AUJ

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.87e-05117314CID000003303
Drugfibrates

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.94e-05118314CID000002797
Drugalpha-naphthoflavone

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.94e-05118314CID000011790
DrugUDP-glucose

UGT2B4 UGT2B7 GPR17 UGT2B28 UGT2B11

1.95e-05247315CID000001166
Drugbenzphetamine

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.00e-05119314CID000002341
Drugphenolate

UGT2B4 UGT2B7 UGT2B28 UGT2B11 BAIAP3

2.23e-05254315CID000000996
Drug2-acetylaminofluorene

UGT2B4 UGT2B7 TAF4 UGT2B28 UGT2B11

2.58e-05262315CID000005897
Drughexobarbital

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.58e-05127314CID000003608
DrugEstriol

UGT2B4 UGT2B7 UGT2B11 FOXA2

2.67e-05128314ctd:D004964
Drug2-hydroxyestriol

UGT2B4 UGT2B7

2.68e-056312CID000014688
DrugAC1L1FK5

UGT2B4 UGT2B7 UGT2B28 UGT2B11

2.75e-05129314CID000003272
Drug4-methylumbelliferone

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.01e-05132314CID003364573
Drugoltipraz

UGT2B4 UGT2B7 UGT2B28 UGT2B11

3.48e-05137314CID000047318
Drugoxazepam glucuronide

UGT2B4 UGT2B7

3.75e-057312CID000160870
Drugranirestat

UGT2B4 UGT2B7

3.75e-057312ctd:C115070
Druganiline

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.00e-05142314CID000006115
Drugbutylated hydroxytoluene

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.11e-05143314CID000031404
Drug2 E1

UGT2B4 UGT2B7 UGT2B28 UGT2B11

4.34e-05145314CID006102788
Drugdisulfiram

UGT2B4 UGT2B7 UGT2B28 UGT2B11

6.07e-05158314CID000003117
DrugRacemic mixture

UGT2B4 UGT2B7 TAF1

6.70e-0558313CID000365464
Drugal-Badry

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.18e-05165314CID000004545
Drugestrone-d4

UGT2B4 UGT2B7 UGT2B28 UGT2B11

7.70e-05168314CID000000698
Drugaminopyrine

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.25e-05171314CID000006009
Drugglucosiduronate

UGT2B4 UGT2B7 UGT2B28 UGT2B11

8.25e-05171314CID000000610
Drug4-nitrophenol

UGT2B4 UGT2B7 UGT2B28 UGT2B11

9.43e-05177314CID000000980
Drug1,4-benzodiazepine

UGT2B4 UGT2B7

9.79e-0511312CID000148431
Drugzomepirac

UGT2B4 UGT2B7

9.79e-0511312CID000005733
DrugTamoxifen citrate [54965-24-1]; Up 200; 7uM; MCF7; HT_HG-U133A

SCN11A SEMA3G BAIAP3 H1-2

1.03e-041813142212_UP
Drugbenzo(a)pyrene

UGT2B4 UGT2B7 UGT2B28 UGT2B11 BAIAP3

1.13e-04358315CID000002336
Drug4-hydroxyestrone

UGT2B7 UGT2B11

1.17e-0412312ctd:C026418
Druguridine 5'-diphosphoglucuronic acid

UGT2B4 UGT2B7 UGT2B28 UGT2B11

1.21e-04189314CID000000390
DrugBiperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ZCWPW1 TAF1 CDC42BPA RECQL5

1.34e-041943143321_DN
Diseaseplasma clozapine-to-N-desmethylclozapine ratio measurement

UGT2B4 UGT2B7 UGT2B11

8.78e-089313EFO_0600040
DiseaseX-19141 measurement

UGT2B4 UGT2B7 UGT2B11

2.98e-0713313EFO_0800799
Diseasephosphatidylcholine 36:4 measurement

UGT2B4 UGT2B28 UGT2B11

8.48e-0718313EFO_0010382
DiseaseX-24947 measurement

UGT2B4 UGT2B7 UGT2B11

1.60e-0622313EFO_0800910
Diseasevitamin D deficiency

UGT2B4 UGT2B7 UGT2B11

7.96e-0637313EFO_0003762
Diseasedisease progression measurement

UGT2B4 UGT2B7 UGT2B11

3.63e-0561313EFO_0008336
Diseaseplatelet component distribution width

DOCK10 JCAD SCN11A ZCWPW1 C22orf31 NDUFV2

1.17e-04755316EFO_0007984
Diseasebacteriemia

UGT2B4 PALLD

1.44e-0417312EFO_0003033
Diseasevitamin D measurement, COVID-19

UGT2B4 UGT2B7

1.22e-0349312EFO_0004631, MONDO_0100096
Diseasediverticular disease

UGT2B4 UGT2B7 UGT2B11

1.92e-03236313EFO_0009959
Diseaseurinary metabolite measurement

UGT2B4 UGT2B7 UGT2B11

2.14e-03245313EFO_0005116
Diseaseserum gamma-glutamyl transferase measurement

UGT2B4 UGT2B7 JCAD TAF4 CDC42BPA

2.45e-03914315EFO_0004532
Diseasevitamin D measurement

UGT2B4 UGT2B7 UGT2B11

5.19e-03336313EFO_0004631
Diseaseneuritic plaque measurement

UGT2B4 UGT2B7 UGT2B11

5.77e-03349313EFO_0006798
Diseaseimmature platelet measurement

DOCK10 JCAD

6.95e-03119312EFO_0803541
Diseasefacial height measurement

KCNB2 NDUFV2

9.76e-03142312EFO_0007856
Diseasetestosterone measurement

UGT2B4 UGT2B7 ZCWPW1 TAF4 UGT2B11

9.96e-031275315EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
KRLCGTFLGGPKPPQ

CTSB

56

P07858
KGSKRGGPLPAKCIQ

BAIAP3

246

O94812
PKPGPTGVKTKPSCG

BRICD5

11

Q6PL45
CGKRLKGPPPSFEGK

GPR17

341

Q13304
KKAGGTPRKASGPPV

H1-2

26

P16403
PPPCKFGEGKLSKRL

C22orf31

91

O95567
EKSGCSAPFPRPKFG

JCAD

276

Q9P266
GKAKKLKFGLPGPPG

ERFE

101

Q4G0M1
PPKPFSCGRSGKGHK

MSL1

316

Q68DK7
CFVKIPREPGRPGKG

FOXD4

161

Q12950
GLPKGVTPAGFPKKA

PALLD

871

Q8WX93
PKDIGGSKAPVPCFG

HENMT1

301

Q5T8I9
PCQGPSKGLSPRFPK

KCNB2

776

Q92953
KPLKCIYGKPGGPLF

DOCK10

711

Q96BY6
FLKKPKAIRPGCQGG

PCARE

21

A6NGG8
PREGPPYEGKKNCKG

FAM181A

221

Q8N9Y4
CFLKVPRSPDKPGKG

FOXA2

216

Q9Y261
KKRKVDCPGPGSGAE

TAF4

1016

O00268
FSGPLSPGGSKRKPK

NHS

1041

Q6T4R5
RKPGKDPGAPDCKYG

TAF1

706

P21675
RKKGCPGSTGFPPKR

CDC42BPA

996

Q5VT25
KPKRVGAGFPKGSCP

RECQL5

651

O94762
CGKGPKRIFAPPAQK

ZCWPW1

11

Q9H0M4
FVGGLHCKPAKPLPK

UGT2B4

276

P06133
FVGGFHCKPAKPLPK

UGT2B11

276

O75310
PKKQPERCLPKGFGC

SCN11A

1011

Q9UI33
GGKVPFPRPGVCPSK

SEMA3G

371

Q9NS98
FVGGLHCKPAKPLPK

UGT2B28

276

Q9BY64
FVGGLHCKPAKPLPK

UGT2B7

276

P16662
TGPKGVKIKGCPSEP

TNS2

1206

Q63HR2
GKIPKPGPRSGRFSC

NDUFV2

211

P19404