Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Septate vagina	UBR1 INTU ZEB2	2.23e-05	12	25	3	HP:0001153
Domain	RCC1	MYCBP2 NEK9	1.51e-03	20	54	2	PF00415
Domain	WD40_repeat_dom	DCAF1 ITFG2 DNAI2 PALB2 FBXW11	1.64e-03	297	54	5	IPR017986
Domain	RCC1_1	MYCBP2 NEK9	1.66e-03	21	54	2	PS00625
Domain	RCC1_2	MYCBP2 NEK9	1.66e-03	21	54	2	PS00626
Domain	RCC1_3	MYCBP2 NEK9	1.66e-03	21	54	2	PS50012
Domain	Reg_chr_condens	MYCBP2 NEK9	1.83e-03	22	54	2	IPR000408
Domain	-	MYCBP2 NEK9	1.83e-03	22	54	2	2.130.10.30
Domain	GUANYLATE_KINASE_2	MAGI3 CARD11	2.00e-03	23	54	2	PS50052
Domain	GUANYLATE_KINASE_1	MAGI3 CARD11	2.00e-03	23	54	2	PS00856
Domain	RCC1/BLIP-II	MYCBP2 NEK9	2.00e-03	23	54	2	IPR009091
Domain	ARM-type_fold	DCAF1 NCAPD3 HIP1 TAF2 DAAM1	2.92e-03	339	54	5	IPR016024
Domain	EF-hand_8	EFCAB6 RYR2	4.34e-03	34	54	2	PF13833
Domain	WD_REPEATS_1	DCAF1 DNAI2 PALB2 FBXW11	8.48e-03	278	54	4	PS00678
Domain	WD_REPEATS_2	DCAF1 DNAI2 PALB2 FBXW11	8.58e-03	279	54	4	PS50082
Domain	WD_REPEATS_REGION	DCAF1 DNAI2 PALB2 FBXW11	8.58e-03	279	54	4	PS50294
Pathway	WP_CILIOPATHIES	INTU KIAA0586 DNAI2 PCARE NEK9 KIAA0753	1.62e-05	184	42	6	M39880
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KMT2B TSR1 PHF3 NAT10 WRN FAM169A TAF2 TEAD1 ZEB2	5.24e-07	608	56	9	36089195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA0586 FAM169A MAGI3 TAOK1 PLEKHH2 NEK9 DOP1A KIAA0753	1.21e-06	493	56	8	15368895
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2B MYCBP2 PHF3 NAT10 SEC23IP TAF2 TEAD1 NEK9	2.68e-06	549	56	8	38280479
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	DCAF1 STAC2 PHF3 TAOK1 DDX53 FBXW11	5.07e-06	272	56	6	18187620
Pubmed	BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA-like breast cancers treated with neoadjuvant chemotherapy.	KMT2B PALB2	7.63e-06	3	56	2	28124401
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MYCBP2 PHF3 MAP4K1 MAGI3 MLXIP NEK9 PABIR2 DOP1A KIAA0753	8.95e-06	861	56	9	36931259
Pubmed	The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.	INTU DAAM1	1.52e-05	4	56	2	26644512
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	MYCBP2 KIAA0586 FBXW11 KIAA0753	2.19e-05	101	56	4	24613305
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UBR1 NCAPD3 KMT2B MYCBP2 PHF3 MAP4K1 TAOK1 PALB2	3.21e-05	774	56	8	15302935
Pubmed	Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.	MAP4K1 CARD11	3.80e-05	6	56	2	19706536
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 DCAF1 INTU PHF3 MLXIP ZEB2	4.90e-05	407	56	6	12693553
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2B MYCBP2 SEC23IP NEK9 ZEB2 PALB2	5.68e-05	418	56	6	34709266
Pubmed	Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.	MYCBP2 ZEB2	7.09e-05	8	56	2	25460509
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 UBR1	9.10e-05	9	56	2	17855541
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NCAPD3 VILL PHF3 TAOK1 TAF2 PLEKHH2 KIAA0753	1.16e-04	689	56	7	36543142
Pubmed	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	WRN RYR2	1.39e-04	11	56	2	17903301
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	DCAF1 UBR1 FBXW11	1.40e-04	62	56	3	18775313
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	WRN DAAM1 PALB2	1.61e-04	65	56	3	27453043
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	NCAPD3 TSR1 PHF3 NAT10 TRMT1L	1.97e-04	332	56	5	32786267
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NCAPD3 MYCBP2 TSR1 PHF3 NAT10 WRN TRMT1L	2.10e-04	759	56	7	35915203
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DCAF1 INTU MYCBP2 PTPRQ SEC23IP WRN PCARE NEK9 PABIR2	2.43e-04	1321	56	9	27173435
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	HIP1 ZNF296 TSR1 MAP4K1 DNAI2 TAOK1 PALB2	3.66e-04	832	56	7	36724073
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	UBR1 NCAPD3 MYCBP2 FBXW11	3.85e-04	212	56	4	33853758
Pubmed	Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.	TEAD1 RYR2	4.28e-04	19	56	2	18316483
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	LMOD3 INTU SEC23IP FAM169A MAGI3 ZEB2 PALB2 RYR2 DOP1A	4.61e-04	1442	56	9	35575683
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MYCBP2 FAM169A MLXIP	5.72e-04	100	56	3	10048485
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	INTU SGSM1 MYCBP2 NAT10 MAGI3 DAAM1 NEK9 DOP1A FBXW11	5.81e-04	1489	56	9	28611215
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	MYCBP2 TSR1 FAM169A NEK9 PALB2 KIAA0753	5.87e-04	645	56	6	25281560
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NCAPD3 HIP1 KMT2B TSR1 PHF3 WRN TAF2 DAAM1 TRMT1L	6.04e-04	1497	56	9	31527615
Pubmed	Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.	DCAF1 PALB2	6.30e-04	23	56	2	22038470
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	PROKR2 MYCBP2 KIAA0586 NAT10 PWWP3B TEAD1 ZBTB18 PABIR2	6.95e-04	1215	56	8	15146197
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DCAF1 TSR1 PHF3 FBXW11	7.25e-04	251	56	4	28077445
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	NCAPD3 PHF3 WRN TRMT1L PALB2	8.11e-04	453	56	5	29656893
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	UBR1 MYCBP2 TSR1	8.81e-04	116	56	3	21282530
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	MYCBP2 FIBP TAOK1 TRMT1L RYR2	8.86e-04	462	56	5	31138677
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TSR1 NAT10 WRN TRMT1L	9.63e-04	271	56	4	32433965
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NCAPD3 KMT2B PHF3 NAT10 WRN TEAD1 MLXIP PALB2	1.04e-03	1294	56	8	30804502
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	UBR1 NCAPD3 TSR1 NAT10 TRMT1L	1.11e-03	486	56	5	30940648
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	DCAF1 MYCBP2 P3H1 WRN MAGI3 PABIR2 FBXW11	1.11e-03	1005	56	7	19615732
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PHF3 NAT10 WRN TRMT1L	1.13e-03	283	56	4	30585729
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SGSM1 KMT2B P3H1 MAGI3 PCARE PWWP3B	1.16e-03	736	56	6	29676528
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NEK9 ZEB2	1.30e-03	33	56	2	30783098
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYCBP2 TSR1 P3H1 NAT10 PABIR2 FBXW11 KIAA0753	1.42e-03	1049	56	7	27880917
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	MAGI3 CARD11	1.08e-03	26	34	2	904
GeneFamily	PDZ domain containing	INTU MAGI3 CARD11	2.88e-03	152	34	3	1220
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	HIP1 TSR1 PHF3 FAM169A MAGI3 TAOK1 TRMT1L TEAD1 ZEB2 PABIR2 PALB2	9.72e-08	532	55	11	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#1_top-relative-expression-ranked_500	PHF3 WRN TAOK1 TAF2 TEAD1 ZEB2 RYR2 FBXW11	1.36e-07	231	55	8	gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_1000	PHF3 WRN TAOK1 TAF2 TEAD1 ZEB2 RYR2 FBXW11	7.86e-06	397	55	8	gudmap_developingLowerUrinaryTract_e14.5_ bladder_1000_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_top-relative-expression-ranked_500	PHF3 WRN TAOK1 TAF2 TEAD1 ZEB2 RYR2 FBXW11	1.20e-05	421	55	8	gudmap_developingLowerUrinaryTract_e14.5_ bladder_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500	PHF3 WRN TAOK1 RYR2 FBXW11	6.78e-05	165	55	5	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	PHF3 TAOK1 TEAD1 ZEB2 RYR2	2.05e-04	209	55	5	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000	MYCBP2 PHF3 WRN TAOK1 RYR2 FBXW11	2.06e-04	330	55	6	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000	PROKR2 ABCA5 MYCBP2 PHF3 WRN TAOK1 TEAD1 RYR2 FBXW11	2.32e-04	818	55	9	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	STAC2 ABCA5 FAM169A MAGI3 DAAM1	3.88e-06	188	56	5	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PHF3 WRN FAM169A MAGI3 DAAM1	4.30e-06	192	56	5	916fbec1c7ab7969bda711886ac88e877e30c280
Drug	Procainamide hydrochloride [614-39-1]; Down 200; 14.8uM; HL60; HT_HG-U133A	DCAF1 VILL ITFG2 TSR1 PHF3 KIAA0586 SEC23IP	5.66e-07	199	56	7	1263_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; HL60; HT_HG-U133A	VILL ITFG2 PHF3 DNAI2 CCL23 RYR2	8.07e-06	194	56	6	6199_DN
Disease	asphyxiating thoracic dystrophy (is_implicated_in)	INTU KIAA0753	6.61e-05	7	53	2	DOID:0050592 (is_implicated_in)
Disease	wellbeing measurement, alcohol consumption measurement	STAC2 IFTAP KIAA0586	3.24e-04	74	53	3	EFO_0007869, EFO_0007878
Disease	exercise test	WRN RYR2	5.89e-04	20	53	2	EFO_0004328
Disease	Familial aplasia of the vermis	KIAA0586 KIAA0753	1.33e-03	30	53	2	C0431399
Disease	Global developmental delay	TAOK1 ZBTB18 FBXW11	1.78e-03	133	53	3	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLEEEMDSKSFDEME	ABCA5	806	Q8WWZ7
EEMDSMVGKILDAID	ARSF	316	P54793
DAETEFMMSKLPLEN	CCL23	26	P55773
LESDVEDMLSPAMET	DOP1A	2011	Q5JWR5
DEEAMEVMEEDPSAK	DNAI2	136	Q9GZS0
EKIPLLMDFDDMDEI	RAD51AP2	686	Q09MP3
DDLVKMLFSPEEMDL	P3H1	691	Q32P28
DDEDDLMEERMKSPF	DCAF1	1316	Q9Y4B6
VSKMERMDSSLPEEE	MAGI3	226	Q5TCQ9
KEEMEMDPKPDLDSD	NEK9	951	Q8TD19
ELKELQSEMEVMAPD	LMOD3	31	Q0VAK6
MEPDSVIEDKTIELM	FBXW11	1	Q9UKB1
KEERAVAEEMMPAAE	KMT2B	381	Q9UMN6
LDGTLKLMEEMEEAD	ITFG2	281	Q969R8
MEPTMKTLSDDLDEA	NAT10	926	Q9H0A0
KDMEEMEIPEKSVDN	PLEKHH2	226	Q8IVE3
QKMDSLDAMEGDVEL	PTPRQ	2311	Q9UMZ3
MAQEKMELDLEPDTS	PABIR2	1	Q7Z309
EIKMELDMALSDLEA	INTU	481	Q9ULD6
PKRMDTEMEDLEEDL	PALB2	661	Q86YC2
MEEDPLLDTDMLMSE	MLXIP	266	Q9HAP2
TMDEQEDLPKDMLEQ	DAAM1	716	Q9Y4D1
DLDMDEEIKPQMSED	IFTAP	106	Q86VG3
DSEFKELMQMLDPGD	EFCAB6	441	Q5THR3
SPESDFESRMKKMEE	FNIP2	726	Q9P278
ESELEPMNGEIMDDS	FAM169A	421	Q9Y6X4
DEADKMLDMEFEPQI	DDX53	376	Q86TM3
SEDGDTPDMKCDDML	RYR2	4796	Q92736
PEMDDYMETLKDEED	CARD11	6	Q9BXL7
DSSPEEEEEDKMSSM	PCARE	486	A6NGG8
DPDSQMDDMDMDLDK	FIBP	221	O43427
DLVALKMVKMEPDDD	MAP4K1	41	Q92918
MEMSDPTVEEEQALK	RSPH6A	676	Q9H0K4
MENMAEEELLPLEKE	TRMT1L	1	Q7Z2T5
DMLIMPKALKEESED	PWWP3B	246	Q5H9M0
EVDMDLSAMDADSPL	TAF2	611	Q6P1X5
PDSEPVLEKDDLMDM	HIP1	321	O00291
LPDVSDDKSELDMME	TAOK1	371	Q7L7X3
EEELDEKDEKSMMCP	MYCBP2	741	O75592
ESDEDLEMEMLKSLE	WRN	466	Q14191
DMESLLMCTVDDLKE	SEC23IP	671	Q9Y6Y8
VEDSKDSPDLEIMMR	KIAA0753	766	Q2KHM9
SKPDKDLLMEEDDMA	NCAPD3	1161	P42695
TDAVDDMEEGLKVLM	TSR1	331	Q2NL82
MTEMSEKENEPDDAA	STAC2	1	Q6ZMT1
LDREDKASDDEMMTP	ZBTB18	326	Q99592
KASDDEMMTPESERV	ZBTB18	331	Q99592
SEMPGKEDSIMEEES	UBR1	1056	Q8IWV7
IESDAPMKEQEAAME	PHF3	1061	Q92576
GDYDLPMDEDEDMTK	PROKR2	31	Q8NFJ6
SLDMALPEKDDVVME	SGSM1	856	Q2NKQ1
DDEAKAPDLMQIMEA	VILL	211	O15195
SEKEDDSSVGEMMLL	ZNF200	141	P98182
MERMSDSADKPIDND	TEAD1	16	P28347
SVDGPEEMKEDYDTM	ZEB2	106	O60315
EEMKEDYDTMGPEAT	ZEB2	111	O60315
IVMSVAKDEEPESMD	KIAA0586	1161	Q9BVV6
PDDEMEMQDLVIELK	ZNF296	21	Q8WUU4