Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	8.82e-06	9	99	3	GO:0160063
GeneOntologyBiologicalProcess	heterotypic cell-cell adhesion	DSP ITGA4 ITGAD ITGAX PTPRC	1.63e-05	66	99	5	GO:0034113
GeneOntologyBiologicalProcess	integrin-mediated signaling pathway	LAMA5 ITGA2 ITGA4 ITGAD ITGAX TLN1	2.97e-05	124	99	6	GO:0007229
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	8.74e-06	9	100	3	GO:0160064
GeneOntologyCellularComponent	integrin complex	ITGA2 ITGA4 ITGAD ITGAX	1.60e-05	32	100	4	GO:0008305
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	3.72e-05	14	100	3	GO:0072379
GeneOntologyCellularComponent	tertiary granule	TCN1 DSP LAMP2 ITGAX PTPRB CNN2	1.38e-04	164	100	6	GO:0070820
GeneOntologyCellularComponent	protein complex involved in cell adhesion	ITGA2 ITGA4 ITGAD ITGAX	1.83e-04	59	100	4	GO:0098636
GeneOntologyCellularComponent	secretory granule	TCN1 DSP ATP6V1E2 LAMP2 CTSA ITGAX DENND4C SPACA7 ADRB2 PTPRB PTPRC TOLLIP MME CNN2	3.29e-04	1014	100	14	GO:0030141
GeneOntologyCellularComponent	TORC2 complex	MAPKAP1 PRR5L	7.98e-04	9	100	2	GO:0031932
GeneOntologyCellularComponent	cell surface	SYNJ2BP WFDC6 ITGA2 ITGA4 ITGAD ITGAX FCRL1 PTPRC CD19 TLN1 TNFRSF13B CD79A MME IL7R	8.13e-04	1111	100	14	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	ITGA2 ITGA4 ITGAD ITGAX PTPRC CD19 TNFRSF13B CD79A IL7R	8.60e-04	519	100	9	GO:0009897
GeneOntologyCellularComponent	side of membrane	ANK1 ITGA2 ITGA4 ITGAD CTSA ITGAX PTPRC CD19 NPTXR TNFRSF13B CD79A IL7R	9.56e-04	875	100	12	GO:0098552
GeneOntologyCellularComponent	focal adhesion	ITGA2 KEAP1 ITGA4 PTPRC TLN1 MME SNTB1 CNN2	1.09e-03	431	100	8	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	ITGA2 KEAP1 ITGA4 PTPRC TLN1 MME SNTB1 CNN2	1.30e-03	443	100	8	GO:0030055
GeneOntologyCellularComponent	TOR complex	MAPKAP1 PRR5L	1.45e-03	12	100	2	GO:0038201
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.58e-07	4	98	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.58e-07	4	98	3	IPR019008
Domain	Integrin_alpha_C_CS	ITGA2 ITGA4 ITGAD ITGAX	1.24e-06	16	98	4	IPR018184
Domain	Integrin_alpha-2	ITGA2 ITGA4 ITGAD ITGAX	2.06e-06	18	98	4	IPR013649
Domain	Integrin_alpha2	ITGA2 ITGA4 ITGAD ITGAX	2.06e-06	18	98	4	PF08441
Domain	Integrin_alpha	ITGA2 ITGA4 ITGAD ITGAX	2.06e-06	18	98	4	IPR000413
Domain	INTEGRIN_ALPHA	ITGA2 ITGA4 ITGAD ITGAX	2.06e-06	18	98	4	PS00242
Domain	Int_alpha_beta-p	ITGA2 ITGA4 ITGAD ITGAX	2.60e-06	19	98	4	IPR013519
Domain	Int_alpha	ITGA2 ITGA4 ITGAD ITGAX	2.60e-06	19	98	4	SM00191
Domain	FG_GAP	ITGA2 ITGA4 ITGAD ITGAX	4.85e-06	22	98	4	PS51470
Domain	FG-GAP	ITGA2 ITGA4 ITGAD ITGAX	6.99e-06	24	98	4	PF01839
Domain	FG-GAP	ITGA2 ITGA4 ITGAD ITGAX	6.99e-06	24	98	4	IPR013517
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	7.70e-06	8	98	3	IPR013784
Domain	Integrin_dom	ITGA2 ITGA4 ITGAD ITGAX	8.28e-06	25	98	4	IPR032695
Domain	Integrin_alpha	ITGA4 ITGAD ITGAX	2.24e-05	11	98	3	PF00357
Domain	Peptidase_M43	PAPPA2 PAPPA	2.73e-05	2	98	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	2.73e-05	2	98	2	PF05572
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	3.86e-05	13	98	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	3.86e-05	13	98	3	2.60.40.1120
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	8.15e-05	3	98	2	IPR011936
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	9.03e-05	17	98	3	IPR008969
Domain	-	PAPPA2 FAT4 LAMA5 NPTXR PAPPA	1.43e-04	95	98	5	2.60.120.200
Domain	LamGL	PAPPA2 PAPPA	1.62e-04	4	98	2	SM00560
Domain	LamG-like	PAPPA2 PAPPA	1.62e-04	4	98	2	IPR006558
Domain	PBC	PBX1 PBX3	1.62e-04	4	98	2	PF03792
Domain	PBX	PBX1 PBX3	1.62e-04	4	98	2	IPR005542
Domain	-	PAPPA2 NOMO1 LRIG2 FCRL1 PTPRB PTPRC LINGO1 CD19 NOMO2 CD79A NOMO3 IL7R	1.81e-04	663	98	12	2.60.40.10
Domain	-	RCBTB1 RPGR TECPR1	2.01e-04	22	98	3	2.130.10.30
Domain	RCC1/BLIP-II	RCBTB1 RPGR TECPR1	2.30e-04	23	98	3	IPR009091
Domain	Ig-like_fold	PAPPA2 NOMO1 LRIG2 FCRL1 PTPRB PTPRC LINGO1 CD19 NOMO2 CD79A NOMO3 IL7R	3.21e-04	706	98	12	IPR013783
Domain	Notch_dom	PAPPA2 PAPPA	5.63e-04	7	98	2	IPR000800
Domain	Notch	PAPPA2 PAPPA	5.63e-04	7	98	2	PF00066
Domain	NL	PAPPA2 PAPPA	5.63e-04	7	98	2	SM00004
Domain	Sushi	PAPPA2 PAPPA C7	2.57e-03	52	98	3	PF00084
Domain	CCP	PAPPA2 PAPPA C7	2.86e-03	54	98	3	SM00032
Domain	SUSHI	PAPPA2 PAPPA C7	3.17e-03	56	98	3	PS50923
Domain	VWA	ITGA2 ITGAD ITGAX	3.17e-03	56	98	3	PF00092
Domain	Sushi_SCR_CCP_dom	PAPPA2 PAPPA C7	3.34e-03	57	98	3	IPR000436
Domain	RCC1	RCBTB1 RPGR	4.87e-03	20	98	2	PF00415
Domain	RCC1_1	RCBTB1 RPGR	5.36e-03	21	98	2	PS00625
Domain	RCC1_2	RCBTB1 RPGR	5.36e-03	21	98	2	PS00626
Domain	RCC1_3	RCBTB1 RPGR	5.36e-03	21	98	2	PS50012
Domain	DEP	RGS7 DEPDC5	5.88e-03	22	98	2	PF00610
Domain	Reg_chr_condens	RCBTB1 RPGR	5.88e-03	22	98	2	IPR000408
Pathway	KEGG_PRIMARY_IMMUNODEFICIENCY	PTPRC CD19 TNFRSF13B CD79A IL7R	1.22e-06	35	77	5	M4085
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGA2 ITGA4 ITGAD ITGAX	1.12e-05	26	77	4	M47
Pathway	KEGG_HEMATOPOIETIC_CELL_LINEAGE	ITGA2 ITGA4 CD19 MME IL7R	1.11e-04	87	77	5	M6856
Pathway	WP_COMPLEMENT_SYSTEM	LAMA5 ITGA2 ITGAX CD19 C7	1.77e-04	96	77	5	M39581
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGA2 ITGA4 ITGAD ITGAX TLN1	2.35e-04	102	77	5	M39577
Pathway	WP_INTEGRINMEDIATED_CELL_ADHESION	ITGA2 ITGA4 ITGAD ITGAX TLN1	2.35e-04	102	77	5	MM15830
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	TCN1 DSP LAMP2 CTSA ITGAX PTPRB PTPRC TOLLIP MME CNN2	2.62e-04	478	77	10	M27620
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	2.31e-08	3	100	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	2.31e-08	3	100	3	25576386
Pubmed	Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.	ITGA2 ITGA4 ITGAD ITGAX	4.51e-08	13	100	4	20563599
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	9.21e-08	4	100	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	9.21e-08	4	100	3	9267806
Pubmed	Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.	CD19 CD79A IL7R	2.30e-07	5	100	3	34193976
Pubmed	Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.	LAMA5 CD19 TNFRSF13B	4.58e-07	6	100	3	23847204
Pubmed	IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches.	ITGAX PTPRC IL7R	8.01e-07	7	100	3	10330270
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA2 ITGA4 ITGAD ITGAX	1.07e-06	27	100	4	31541017
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	1.28e-06	8	100	3	15257293
Pubmed	CD11c+ T-bet+ B Cells Require IL-21 and IFN-γ from Type 1 T Follicular Helper Cells and Intrinsic Bcl-6 Expression but Develop Normally in the Absence of T-bet.	ITGAX CD19 CD79A	1.28e-06	8	100	3	32680956
Pubmed	Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.	ITGAX PTPRC IL7R	1.91e-06	9	100	3	16815646
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	1.91e-06	9	100	3	36261522
Pubmed	Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.	PTPRC CD19 IL7R	2.73e-06	10	100	3	15909309
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	PAPPA2 COL25A1 ITGA4 PAPPA	3.15e-06	35	100	4	22407321
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	3.74e-06	11	100	3	32820719
Pubmed	Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.	ITGAD ITGAX	8.18e-06	2	100	2	9598326
Pubmed	Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.	MAPKAP1 CD19	8.18e-06	2	100	2	30705387
Pubmed	Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.	CD19 CD79A	8.18e-06	2	100	2	36469024
Pubmed	CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes.	PTPRC IL7R	8.18e-06	2	100	2	20624943
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	8.18e-06	2	100	2	21586553
Pubmed	Dynamics of the splenic innate-like CD19⁺CD45Rlo cell population from adult mice in homeostatic and activated conditions.	PTPRC CD19	8.18e-06	2	100	2	22837485
Pubmed	Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.	LAMA5 ITGA4	8.18e-06	2	100	2	38154529
Pubmed	BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2.	BACH1 ITGA2	8.18e-06	2	100	2	37311571
Pubmed	Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.	CD19 CD79A	8.18e-06	2	100	2	28461481
Pubmed	A subset of CD45+/CD19 - cells in bone marrow may be associated with clinical outcomes of patients with mantle cell lymphoma.	PTPRC CD19	8.18e-06	2	100	2	25739938
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	8.18e-06	2	100	2	11513734
Pubmed	B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells.	PTPRC CD19	8.18e-06	2	100	2	18495958
Pubmed	Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.	CD19 CD79A	8.18e-06	2	100	2	27883180
Pubmed	A system for reconstructing B cell antigen receptor signaling in the mouse myeloma J558L cell line.	PTPRC CD19	8.18e-06	2	100	2	23454348
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	8.18e-06	2	100	2	29144175
Pubmed	Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor.	LAMP2 CTSA	8.18e-06	2	100	2	12505983
Pubmed	Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.	ITGA2 ITGA4	8.18e-06	2	100	2	26779610
Pubmed	Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.	ITGA2 ITGA4	8.18e-06	2	100	2	19463772
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	TPR DSP DENND4C EFR3A UBAP2L TLN1 CNN2	9.64e-06	256	100	7	33397691
Pubmed	Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.	ITGAX PTPRC CD19	1.02e-05	15	100	3	14990792
Pubmed	Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.	ITGAX PTPRC IL7R	1.52e-05	17	100	3	19783990
Pubmed	Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.	ITGA2 ITGA4 ITGAX PTPRC	1.69e-05	53	100	4	1431091
Pubmed	Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.	LAMA5 ITGA2 ITGA4	1.82e-05	18	100	3	19686679
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SUN1 MAML1 LAMA5 KEAP1 EFR3A TUBGCP6 ABCA5 MIB1 DEPDC5	2.27e-05	529	100	9	14621295
Pubmed	Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.	CD19 CD79A	2.45e-05	3	100	2	23343763
Pubmed	B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.	PTPRC CD79A	2.45e-05	3	100	2	10429672
Pubmed	Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.	CD19 TLN1	2.45e-05	3	100	2	20923969
Pubmed	Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.	BACH1 KEAP1	2.45e-05	3	100	2	26698668
Pubmed	The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.	PBX1 PBX3	2.45e-05	3	100	2	15169896
Pubmed	Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma.	PTPRC CD19	2.45e-05	3	100	2	21599592
Pubmed	Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss.	ITGA2 IL7R	2.45e-05	3	100	2	26408663
Pubmed	E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.	CD19 CD79A	2.45e-05	3	100	2	27758892
Pubmed	HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.	PBX1 PBX3	2.45e-05	3	100	2	11571641
Pubmed	Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.	CD19 CD79A	2.45e-05	3	100	2	25676421
Pubmed	NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.	PTPRC CD19	2.45e-05	3	100	2	19428458
Pubmed	A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b.	PBX1 PBX3	2.45e-05	3	100	2	10679934
Pubmed	Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma.	LAMP2 KEAP1	2.45e-05	3	100	2	26350055
Pubmed	CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.	ITGAX PTPRC	2.45e-05	3	100	2	25963626
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	2.45e-05	3	100	2	18805800
Pubmed	Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.	BACH1 KEAP1	2.45e-05	3	100	2	23455180
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	2.45e-05	3	100	2	29532882
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	2.45e-05	3	100	2	20642865
Pubmed	CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.	PTPRC CD19	2.45e-05	3	100	2	18059271
Pubmed	MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response.	CD19 CD79A	2.45e-05	3	100	2	27895164
Pubmed	Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases.	PTPRB PTPRC	2.45e-05	3	100	2	1373652
Pubmed	Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.	CD19 CD79A	2.45e-05	3	100	2	22517907
Pubmed	The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement.	CD19 CD79A	2.45e-05	3	100	2	35139388
Pubmed	The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.	PBX1 PBX3	2.45e-05	3	100	2	11468159
Pubmed	A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development.	CD79A CNN2	2.45e-05	3	100	2	26046660
Pubmed	LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.	CD19 CD79A	2.45e-05	3	100	2	30936881
Pubmed	CD4+CD45RO+CD25-/lowCD127+: CD4+CD45RO+CD25hiCD127-/low Ratio in Peripheral Blood: A Useful Biomarker to Detect Cardiac Allograft Vasculopathy in Heart Transplanted Patients.	PTPRC IL7R	2.45e-05	3	100	2	25539460
Pubmed	Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments.	ITGA4 ITGAX PTPRC	3.41e-05	22	100	3	21464233
Pubmed	Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.	ITGAX PTPRC IL7R	3.92e-05	23	100	3	12648490
Pubmed	Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.	ITGA2 ITGA4 TLN1	3.92e-05	23	100	3	23152823
Pubmed	E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells.	CD19 CD79A	4.89e-05	4	100	2	32005754
Pubmed	Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation.	ITGA4 ITGAX	4.89e-05	4	100	2	8020569
Pubmed	Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.	CD19 IL7R	4.89e-05	4	100	2	16938836
Pubmed	Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.	ITGA4 TLN1	4.89e-05	4	100	2	17597073
Pubmed	Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia.	ASXL1 PTPRC	4.89e-05	4	100	2	19861679
Pubmed	Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.	CD19 CD79A	4.89e-05	4	100	2	26301816
Pubmed	Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.	CD19 CD79A	4.89e-05	4	100	2	30467111
Pubmed	Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway.	LAMP2 PTPRC	4.89e-05	4	100	2	15155767
Pubmed	Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation.	PTPRC CD79A	4.89e-05	4	100	2	25267612
Pubmed	CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.	CD19 CD79A	4.89e-05	4	100	2	21795747
Pubmed	Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.	ITGA4 ITGAX	4.89e-05	4	100	2	25278023
Pubmed	Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.	ITGA4 CD79A	4.89e-05	4	100	2	34888947
Pubmed	The adaptor protein Shc plays a key role during early B cell development.	CD19 CD79A	4.89e-05	4	100	2	19828641
Pubmed	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.	CD19 CD79A	4.89e-05	4	100	2	29520062
Pubmed	Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients.	PTPRC IL7R	4.89e-05	4	100	2	17591854
Pubmed	The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling.	PTPRC IL7R	4.89e-05	4	100	2	24551160
Pubmed	Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.	CD19 CD79A	4.89e-05	4	100	2	23264658
Pubmed	FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.	KEAP1 USP16	4.89e-05	4	100	2	37777507
Pubmed	The impact of hypoxia on B cells in COVID-19.	CD19 CD79A	4.89e-05	4	100	2	35189575
Pubmed	c-Myb is required for pro-B cell differentiation.	CD19 CD79A	4.89e-05	4	100	2	19843942
Pubmed	Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.	PBX1 PBX3	4.89e-05	4	100	2	18723445
Pubmed	Ion channel TRPV2 is critical in enhancing B cell activation and function.	PTPRC CD79A	4.89e-05	4	100	2	38353705
Pubmed	Testosterone is an endogenous regulator of BAFF and splenic B cell number.	CD19 CD79A	4.89e-05	4	100	2	29802242
Pubmed	B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.	CD19 TNFRSF13B	4.89e-05	4	100	2	31771880
Pubmed	MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.	CD19 CD79A	4.89e-05	4	100	2	31291582
Pubmed	Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells.	CD19 CD79A	4.89e-05	4	100	2	33750849
Pubmed	B-cell development fails in the absence of the Pbx1 proto-oncogene.	CD19 PBX1	4.89e-05	4	100	2	17244677
Pubmed	Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.	CD19 CD79A	4.89e-05	4	100	2	25044405
Pubmed	Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.	CD19 CD79A	4.89e-05	4	100	2	18978794
Pubmed	Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.	PTPRC CD79A	4.89e-05	4	100	2	21788582
Cytoband	1q21.3	UBE2Q1 UBAP2L RPTN SLC27A3	1.30e-04	117	100	4	1q21.3
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	LAMP2 ITGA2 ITGA4 ITGAD ITGAX FCRL1 PTPRC CD19 TNFRSF13B CD79A MME IL7R	2.79e-08	394	69	12	471
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA2 ITGA4 ITGAD ITGAX	5.71e-07	18	69	4	1160
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	1.44e-05	2	69	2	897
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEB2 POTEB	1.09e-03	13	69	2	685
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 PAPPA C7	1.34e-03	57	69	3	1179
GeneFamily	Cathepsins	CTSA CTSO	1.46e-03	15	69	2	470
GeneFamily	Cadherin related	FAT4 CDH23	1.88e-03	17	69	2	24
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRB PTPRC	2.88e-03	21	69	2	813
GeneFamily	TALE class homeoboxes and pseudogenes	PBX1 PBX3	4.40e-03	26	69	2	526
Coexpression	KLEIN_TARGETS_OF_BCR_ABL1_FUSION	PTPRC CD19 TNFRSF13B CD79A IL7R	8.85e-07	46	100	5	M2569
Coexpression	CUI_TCF21_TARGETS_2_DN	SYNJ2BP ZFYVE16 DSP ITGA2 COL25A1 ITGA4 PTPRB PTPRC CSGALNACT2 ABCA5 MME SNTB1 SLC27A3 TECPR1	4.50e-06	854	100	14	M1533
Coexpression	CUI_TCF21_TARGETS_2_DN	SYNJ2BP ZFYVE16 DSP ITGA2 COL25A1 ITGA4 PTPRB PTPRC CSGALNACT2 ABCA5 MME SNTB1 SLC27A3 TECPR1	7.01e-06	888	100	14	MM1018
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_6H_UP	ANK1 ZFYVE16 BACH1 USP16 USP32 CD79A IL7R	1.15e-05	199	100	7	M7712
Coexpression	GSE19923_WT_VS_HEB_KO_DP_THYMOCYTE_UP	TCF20 ZFYVE16 KLC4 ITGAX CELA1 CD79A PBX3	1.19e-05	200	100	7	M7279
Coexpression	GAO_LARGE_INTESTINE_ADULT_CI_MESENCHYMAL_CELLS	LAMA5 ITGA4 PTPRC CSGALNACT2 CD19 TNFRSF13B CD79A IL7R	7.41e-05	361	100	8	M39166
Coexpression	GSE43863_NAIVE_VS_TFH_CD4_EFF_TCELL_D6_LCMV_UP	MAPKAP1 TPR ITGA2 TLN1 RPGR PBX1	1.11e-04	197	100	6	M9725
Coexpression	MULLIGHAN_MLL_SIGNATURE_1_UP	CTSA ITGAX PPID ADRB2 TOLLIP PBX3 SNTB1 SLC27A3	1.16e-04	385	100	8	M17856
Coexpression	GSE21063_WT_VS_NFATC1_KO_3H_ANTI_IGM_STIM_BCELL_UP	PRR5L ANK1 NLRX1 ITGA4 CTSA FCRL1	1.17e-04	199	100	6	M8263
Coexpression	SENESE_HDAC3_TARGETS_UP	MAPKAP1 TPR TCN1 BACH1 USP16 PTPRB USP32 PAPPA IL7R	1.18e-04	495	100	9	M8451
Coexpression	GSE29164_UNTREATED_VS_CD8_TCELL_TREATED_MELANOMA_DAY3_DN	BACH1 CHD9 FCRL1 CSGALNACT2 TNFRSF13B IL7R	1.20e-04	200	100	6	M8486
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_EFFECTOR_CD8_TCELL_90MIN_UP	KEAP1 CTSA ITGAX GOT1L1 TNFRSF13B DEPDC5	1.20e-04	200	100	6	M9235
Coexpression	GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN	MAML1 CHD9 ITGA4 KLC4 PRRC2B TECPR1	1.20e-04	200	100	6	M5705
Coexpression	GSE7764_NKCELL_VS_SPLENOCYTE_DN	ANK1 CD19 RCBTB1 TNFRSF13B CD79A CTSO	1.20e-04	200	100	6	M5722
Coexpression	DESCARTES_FETAL_LIVER_LYMPHOID_CELLS	FCRL1 CD19 CD79A MME IL7R	1.29e-04	127	100	5	M40232
Coexpression	GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_2H_UP	TCF20 CELA1 TOLLIP CNOT2 PRRC2B	1.33e-04	128	100	5	M6083
Coexpression	STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	CHD9 SLC8A1 LINGO1 NPTXR PBX1 PRRC2B	1.41e-04	206	100	6	M2817
Coexpression	GSE32901_NAIVE_VS_TH1_CD4_TCELL_UP	PDHA2 ITGA4 ADRB2 PTPRB SNTB1	1.49e-04	131	100	5	M8933
Coexpression	STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	CHD9 SLC8A1 LINGO1 NPTXR PBX1 PRRC2B	1.49e-04	208	100	6	MM581
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	ASXL1 BACH1 MAML1 CHD9 KEAP1 ADRB2 CNOT2	1.55e-04	300	100	7	M8702
CoexpressionAtlas	BM Top 100 - heart ventricle	DSP LMOD2 SLC8A1 HRC C7	2.03e-05	71	99	5	BM Top 100 - heart ventricle
ToppCell	facs-Marrow-T-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA2 ITGA4 FCRL1 PTPRC CD19 CD79A IL7R TECPR1	9.46e-09	185	100	8	e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KEAP1 ITGA4 RGS7 FCRL1 PTPRC CD19 TNFRSF13B CD79A	1.74e-08	200	100	8	4f7be296be0cd54cfc62cc93263fde26210c61f4
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA2 ITGA4 ITGAD ITGAX PTPRC CNN2 IL7R	8.68e-08	163	100	7	d18fee517e0daed51f89703f94f218567c83cb03
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA2 ITGA4 ITGAD ITGAX PTPRC CNN2 IL7R	8.68e-08	163	100	7	f4a6e28ad3c1fcbf62ed9b2bf09f65d2ab0b31d1
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA4 PTPRC CD19 TNFRSF13B CD79A MME IL7R	1.16e-07	170	100	7	e319ab46842d028898c09d6d8f056f896edb1558
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ANK1 LAMA5 FCRL1 CD19 TNFRSF13B CD79A PBX1	1.47e-07	176	100	7	052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A CNN2	1.71e-07	180	100	7	14ca8875af7cceead88fec147a4c0ef4d5a41f26
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-B_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA4 ITGAD CD19 TNFRSF13B CD79A MME IL7R	1.71e-07	180	100	7	cb6b11883f42c8beff07f899036c803d786ac6a3
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	1.77e-07	181	100	7	51e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CHD9 ITGA4 FCRL1 PTPRC TNFRSF13B CD79A	1.84e-07	182	100	7	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A CNN2 IL7R	1.91e-07	183	100	7	56038766980a4186ecd3b4a327a91c12979d2364
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A CNN2 IL7R	1.91e-07	183	100	7	eb2f37c3d6d0502fb9eb512537fc2a002a1b92ed
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CHD9 ITGA4 PTPRC TLN1 TNFRSF13B IL7R	1.98e-07	184	100	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R TECPR1	1.98e-07	184	100	7	b12fb85a064f715a4f0ada1df8e422c359b573cf
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	2.06e-07	185	100	7	8fc357ee041bfd588986730a52ea2021b5f88941
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	BACH1 CDH23 ITGA4 ITGAX SLC8A1 PTPRC CSGALNACT2	2.38e-07	189	100	7	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A MME	2.46e-07	190	100	7	424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A MME	2.55e-07	191	100	7	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	BACH1 ITGAX DENND4C SLC8A1 MME SNTB1 IL7R	2.74e-07	193	100	7	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	SUN1 BACH1 ITGAX FCRL1 CD19 TNFRSF13B CD79A	2.74e-07	193	100	7	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	5'-Adult-Appendix-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA4 FCRL1 PTPRC CD19 CD79A CNN2 IL7R	3.04e-07	196	100	7	3f065139f76ed048875cd6c03aa02300db2b6574
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	1.19e-06	151	100	6	ee56b88c56c3b6a5ec9644c43cae521ea0e05920
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	1.19e-06	151	100	6	2c239b09970acbaa90c5ebe1097f453c516f868e
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	1.24e-06	152	100	6	b750302d442160a1007659c2386ac90282bf95d2
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRR5L ITGA4 ITGAX PTPRC BPIFB4 SLC27A3	1.55e-06	158	100	6	90ca742739a208d457db087655ba3d1c18a9da57
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 ITGAD ITGAX PTPRC BPIFB4 SLC27A3	1.67e-06	160	100	6	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	Adult-Immune-B_cell-D231\|Adult / Lineage, Cell type, age group and donor	RGS7 FCRL1 CD19 CELA1 TNFRSF13B CD79A	1.85e-06	163	100	6	4f5821299b265663c7d0352b28285f56e1988841
ToppCell	facs-Heart-LA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGBD1 ITGA2 ITGA4 GOT1L1 PTPRC IL7R	2.21e-06	168	100	6	16c3313c4186fa327d71215f8eebc31fc12ff1c0
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGBD1 ITGA2 ITGA4 GOT1L1 PTPRC IL7R	2.21e-06	168	100	6	24d1e0a05cda09ee3b80208d75cb2b601023f3bf
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD5 FCRL1 PTPRC CD19 CD79A IL7R	2.21e-06	168	100	6	68ef5d1043fca804032669bf990edf110d65cf63
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD5 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.21e-06	168	100	6	784ce773521e5d74570f45120e56d112bc76ff49
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGBD1 ITGA2 ITGA4 GOT1L1 PTPRC IL7R	2.21e-06	168	100	6	b952af95a68888adedd03b1b60836d18524611ab
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-B_cells-Pro-B\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRC CD19 TNFRSF13B CD79A MME IL7R	2.29e-06	169	100	6	7fd13b6e6041032697d36dd215f6b943d4675cf2
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD5 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.37e-06	170	100	6	7a4ed69c807c3761210776e8fe6680d1bd892e82
ToppCell	COVID-19-kidney-Bcells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.45e-06	171	100	6	8e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	2.53e-06	172	100	6	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	2.53e-06	172	100	6	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.62e-06	173	100	6	62ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ANK1 SUN1 RGS7 NOMO1 ABCA5 USP32	2.71e-06	174	100	6	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.71e-06	174	100	6	1b2a2129c08bac01fc638692313b196759a1e0d7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.71e-06	174	100	6	5bde24eb588dc588efc413811379548120ec0c7f
ToppCell	wk_08-11-Hematologic_Lymphocytic-B-Large_pre-B\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.89e-06	176	100	6	78417a5ac2e45e97e7b4c56c78c25879a1b58f97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.89e-06	176	100	6	274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell	facs-GAT-Fat-3m-Lymphocytic\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R	2.89e-06	176	100	6	2e3f25a338842384517656d05776a52cbfc62b52
ToppCell	facs-GAT-Fat-3m-Lymphocytic-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R	2.89e-06	176	100	6	0823088bc6b19c7ad784d83c2ccdfae80611afab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.89e-06	176	100	6	d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.99e-06	177	100	6	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.99e-06	177	100	6	b07e6139618d888a9fd7cf43cad0d86a3f63e09e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	BACH1 RGS7 FCRL1 CD19 TNFRSF13B CD79A	2.99e-06	177	100	6	37d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.99e-06	177	100	6	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	2.99e-06	177	100	6	6376ec12322c04d5d37ec2fdc376700464cbc7fb
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.29e-06	180	100	6	b83d067dee641941c596e4a25d81327931b6ad61
ToppCell	COVID-19-kidney-Bcells\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.29e-06	180	100	6	5650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.29e-06	180	100	6	65c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCell	11.5-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	ANK1 ITGA4 CD19 TNFRSF13B CD79A IL7R	3.40e-06	181	100	6	727344d7b2953568b7b3463398c7d56878cf2c2b
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.40e-06	181	100	6	d909821355f4bc9e35387cda6ecf7c56793d9da4
ToppCell	PND10-Immune\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA4 PTPRC CD19 TNFRSF13B CD79A IL7R	3.40e-06	181	100	6	ef424f7eefe1b190a2be2ebcae7652eb8e7ba883
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.40e-06	181	100	6	52935c496b45207a173b5ac7812f46210c3f74b0
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	3.51e-06	182	100	6	cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CHD9 ITGA4 PTPRC CD19 CD79A	3.51e-06	182	100	6	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	3.51e-06	182	100	6	71cfd0b6d464e3e1b1cca34f423abdf699cda48a
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA4 PTPRC CD19 TNFRSF13B CD79A IL7R	3.62e-06	183	100	6	f929c4a42855313641008385f4e785e2a1c5a139
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.62e-06	183	100	6	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.62e-06	183	100	6	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.74e-06	184	100	6	f4c9272d5cc4a70df051413b5c60ca6d1d80eb84
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMP2 DENND4C PTPRC CSGALNACT2 MME SNTB1	3.74e-06	184	100	6	840fac463665ed18752f402f7d1ef2e5052bdf74
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R	3.74e-06	184	100	6	8fa7aa2a954f66576ada56670b4e1bb122864761
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R	3.74e-06	184	100	6	b5fbfcf8516c2dc20dffc36803692505a63f1297
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CHD9 ITGA4 PTPRC CD19 CD79A	3.85e-06	185	100	6	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	COVID-19-lung-B_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	3.85e-06	185	100	6	e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 ADRB2 PTPRC CD19 TNFRSF13B CD79A	3.98e-06	186	100	6	a8fcb440d88770f95678c5d28413fc4d847f42a8
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	SUN1 ITGA4 ITGAD LRIG2 PTPRC NOMO2	3.98e-06	186	100	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 ADRB2 PTPRC CD19 TNFRSF13B CD79A	3.98e-06	186	100	6	6b2d15e2756d4d4d68ad600e4a6c074edc3488f2
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ITGA4 FCRL1 PTPRC CD19 CD79A IL7R	4.10e-06	187	100	6	9d298f43ae81d72091b31aaa6df41046d4aa31c5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	4.10e-06	187	100	6	8fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCell	facs-Lung-18m-Hematologic-lymphocytic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	4.10e-06	187	100	6	f279ed1b8f93b4d9ed67c209350d9fd90aec7e67
ToppCell	Immune-B_cell\|World / Lineage, Cell type, age group and donor	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	4.10e-06	187	100	6	795690c6306c366e733279491138d0cd9b469b21
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	4.10e-06	187	100	6	edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCRL1 PTPRC CD19 TNFRSF13B CD79A CNN2	4.23e-06	188	100	6	7b56c680e9f1851cb961b0f8faeeb987685ae36d
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	4.23e-06	188	100	6	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRC CD19 TNFRSF13B CD79A CNN2 IL7R	4.23e-06	188	100	6	2951c4dcece3c9e4fb627097a6c40fd12e261d0f
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	4.23e-06	188	100	6	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	4.23e-06	188	100	6	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Lung-3m-Hematologic-lymphocytic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCRL1 PTPRC CD19 TNFRSF13B CD79A IL7R	4.23e-06	188	100	6	2ab75632860934f067a47be5af18bb3ad630bb68
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	4.36e-06	189	100	6	1b84ff069e95ff113d8d861f38e07a08eb3d7070
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHD9 FCRL1 CD19 CD79A MME RPGR	4.36e-06	189	100	6	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	4.36e-06	189	100	6	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DSP BACH1 FCRL1 CD19 TNFRSF13B CD79A	4.36e-06	189	100	6	886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCell	facs-SCAT-Fat-3m-Lymphocytic\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	4.36e-06	189	100	6	f4b8415edf538ce152703ad2c07be96af12b1acd
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP YIPF7 LMOD2 HRC	4.36e-06	189	100	6	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DSP BACH1 FCRL1 CD19 TNFRSF13B CD79A	4.36e-06	189	100	6	5f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCell	facs-MAT-Fat-3m-Lymphocytic-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	4.63e-06	191	100	6	530469909ab0994bece37945e9098359077b0824
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 DSP YIPF7 LMOD2 SLC8A1 HRC	4.63e-06	191	100	6	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	facs-MAT-Fat-3m-Lymphocytic\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCRL1 PTPRC CD19 CD79A CNN2 IL7R	4.63e-06	191	100	6	f7a81acb938ce5d383326840dd45f7dd2cf12b1d
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 DSP YIPF7 LMOD2 SLC8A1 HRC	4.63e-06	191	100	6	97fb4232417a39801e87725755fd16a57c250209
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ITGA4 FCRL1 PTPRC CD19 TNFRSF13B CD79A	4.63e-06	191	100	6	14b11244c330cc4fe897253aaaf0df80caa01a55
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 DSP YIPF7 LMOD2 SLC8A1 HRC	4.63e-06	191	100	6	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 DSP YIPF7 LMOD2 SLC8A1 HRC	4.63e-06	191	100	6	715f5b449b8e075959c05a5b38389df319663164
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN4 ANK1 DSP LMOD2 SLC8A1 HRC	4.77e-06	192	100	6	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 DSP YIPF7 LMOD2 SLC8A1 HRC	4.77e-06	192	100	6	f6a4e348406a852ace9fb21db8fbdff539217645
Drug	9-OH-B220	ITGAX PTPRC CD19 TNFRSF13B CD79A MME IL7R	1.38e-06	127	99	7	CID000130705
Drug	tesmilifene	ITGA4 ITGAX PTPRC	4.40e-06	8	99	3	ctd:C043062
Drug	AC1O3MFW	ITGA2 ITGA4 ITGAX CELA1	6.36e-06	28	99	4	CID006332187
Drug	Tipiracil	PTPRB CD19 CD79A MME IL7R	6.89e-06	61	99	5	CID006323266
Drug	AC1L4RU2	ITGAX CD19 TNFRSF13B CD79A MME	9.43e-06	65	99	5	CID000191080
Drug	Triprolidine	ITGA4 ITGAX PTPRC	1.71e-05	12	99	3	ctd:D014311
Disease	Severe Combined Immunodeficiency, Autosomal Recessive, T Cell Negative, B Cell Positive, NK Cell Positive	PTPRC IL7R	1.07e-05	2	97	2	C1837028
Disease	systemic lupus erythematosus	KCP CDH23 CHD9 KEAP1 COL25A1 ITGAX LRIG2 PTPRC LINGO1 RCBTB1 TNFRSF13B IL7R	1.24e-05	799	97	12	MONDO_0007915
Disease	sleep duration	MAPKAP1 ANK1 CDH23 POU3F2 YIPF7 SLC8A1 PBX1 PBX3	2.66e-05	362	97	8	EFO_0005271
Disease	neutrophil count	PAPPA2 PRUNE2 UBE2Q1 MAML1 CDH23 CHD9 ITGA4 LRIG2 ADRB2 PTPRC LINGO1 RCBTB1 CELA1 PBX1 CNN2	4.43e-05	1382	97	15	EFO_0004833
Disease	response to mTOR inhibitor	BACH1 USP32 PBX3	7.52e-05	25	97	3	EFO_0005417
Disease	IMMUNODEFICIENCY, COMMON VARIABLE, 2	CD19 TNFRSF13B	1.06e-04	5	97	2	240500
Disease	Immunodeficiency, common variable, 2	CD19 TNFRSF13B	1.06e-04	5	97	2	cv:C3150354
Disease	glutamate measurement	BACH1 CDH23 POU3F2	1.18e-04	29	97	3	EFO_0010487
Disease	vitamin B12 measurement	ELAPOR2 TCN1 RGS7	1.59e-04	32	97	3	EFO_0004620
Disease	granulocyte percentage of myeloid white cells	ANK1 MAML1 CHD9 ITGA4 ADRB2 TNFRSF13B	2.63e-04	268	97	6	EFO_0007997
Disease	lymphocyte percentage of leukocytes	ANK1 CDH23 ITGA4 SLC8A1 ADRB2 PTPRC RCBTB1 TNFRSF13B IL7R	3.48e-04	665	97	9	EFO_0007993
Disease	congestive heart failure (biomarker_via_orthology)	SLC8A1 ADRB2 NPTXR MME	4.37e-04	107	97	4	DOID:6000 (biomarker_via_orthology)
Disease	pneumonia (implicated_via_orthology)	ITGA4 ADRB2	4.73e-04	10	97	2	DOID:552 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	BACH1 CDH23 CHD9	5.69e-04	49	97	3	EFO_0006954, EFO_1001069
Disease	Immunoglobulin Deficiency, Late-Onset	CD19 TNFRSF13B	5.77e-04	11	97	2	C2936665
Disease	Acquired Hypogammaglobulinemia	CD19 TNFRSF13B	5.77e-04	11	97	2	C2936664
Disease	waist-hip ratio, body mass index	KEAP1 EFR3A	6.91e-04	12	97	2	EFO_0004340, EFO_0004343
Disease	Agammaglobulinemia	CD19 CD79A	6.91e-04	12	97	2	C0001768
Disease	Common variable immunodeficiency	CD19 TNFRSF13B	8.15e-04	13	97	2	cv:C0009447
Disease	neutrophil percentage of leukocytes	ANK1 CDH23 ITGA4 SLC8A1 ADRB2 TNFRSF13B CNN2 IL7R	9.18e-04	610	97	8	EFO_0007990
Disease	systemic lupus erythematosus, COVID-19	KCP KEAP1 ITGAX	9.32e-04	58	97	3	MONDO_0007915, MONDO_0100096
Disease	severe combined immunodeficiency (is_implicated_in)	PTPRC IL7R	9.49e-04	14	97	2	DOID:627 (is_implicated_in)
Disease	Opioid use measurement	PBX3 SNTB1	1.09e-03	15	97	2	EFO_0009937
Disease	Common Variable Immunodeficiency	CD19 TNFRSF13B	1.09e-03	15	97	2	C0009447
Disease	platelet-to-lymphocyte ratio	ANK1 NLRX1 CDH23 ITGA4 PTPRC IL7R	1.28e-03	363	97	6	EFO_0008446
Disease	Hypogammaglobulinemia	CD19 CD79A	1.41e-03	17	97	2	C0086438
Disease	Astrocytosis	ITGA2 ITGA4	1.41e-03	17	97	2	C3887640
Disease	Gliosis	ITGA2 ITGA4	1.41e-03	17	97	2	C0017639
Disease	immature granulocyte count	ITGA4 DEPDC5	1.41e-03	17	97	2	EFO_0803542
Disease	granulocyte count	MAML1 ITGA4 ADRB2 RCBTB1 CNN2	1.54e-03	254	97	5	EFO_0007987
Disease	Omenn Syndrome	PTPRC IL7R	1.76e-03	19	97	2	C2700553
Disease	Severe Combined Immunodeficiency	PTPRC IL7R	1.96e-03	20	97	2	C0085110
Disease	age of onset of asthma	PTPRC UBAP2L IL7R	2.27e-03	79	97	3	OBA_2001001
Disease	monocyte percentage of leukocytes	MAML1 CDH23 CHD9 ITGA4 ADRB2 PTPRC TNFRSF13B IL7R	2.85e-03	731	97	8	EFO_0007989
Disease	lymphocyte count	ANK1 CDH23 KEAP1 ITGA4 PPID PTPRC TLN1 TNFRSF13B PAPPA PBX1 CNN2 IL7R	3.07e-03	1464	97	12	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
NYEELSEGNVNGNIS	ABCA5	446	Q8WWZ7
GAQQQGINYQELTSG	C2orf16	6	Q68DN1
GNSEPGYARGQESQQ	BACH1	686	O14867
SNGNTGEQSGYHVEQ	ADRB2	356	P07550
QYGHIETNDNTAQLG	BPIFB4	86	P59827
EQSGTHGYLGLNSQQ	GOT1L1	346	Q8NHS2
LLQYGGSANAESVQG	ANK1	621	P16157
GANGEIAYTIAEGNT	FAT4	1026	Q6V0I7
LQGTYQDVGSLNIGD	CD79A	206	P11912
FGYNVSVNENVGGGT	CDH23	1531	Q9H251
FEANDLQGGSVGSVN	EFR3A	351	Q14156
GGSDSNGSYCQQVDI	ASXL1	966	Q8IXJ9
FGLNYSNCLGTGDNQ	RCBTB1	46	Q8NDN9
QDGNGRENVGIYNLS	NOMO3	606	P69849
ALYQQLAQGNAVGGS	DRD5	16	P21918
LQYFGQALSGGQDLT	ITGAX	581	P20702
HGADGNIQDEYGNTA	POTEB2	191	H3BUK9
LSRGQGATAAQQGGY	KLC4	191	Q9NSK0
TFGNSQNIGEQGYSS	DEPDC5	1141	O75140
DSATSPQNGDQQNGY	MAML1	116	Q92585
NSANNQGSVLDYGNT	MAML1	501	Q92585
NVGQNTSVSAAYGQN	MAML1	786	Q92585
QSLNGDSYQGAQVGA	PBX1	351	P40424
DSYQGAQVGANVQSQ	PBX1	356	P40424
SLNGDSYQGSQVGAN	PBX3	356	P40426
QDGNGRENVGIYNLS	NOMO2	606	Q5JPE7
TTKSGQYEANEQGNG	PTPRB	801	P23467
GQINGTTGYEEAAAQ	MTO1	431	Q9Y2Z2
GINGTVNYDSVNSDN	LMOD2	146	Q6P5Q4
GDQGATEIIDYNGNL	COL25A1	421	Q9BXS0
GENIADNGGLGQAYR	MME	646	P08473
QDGNGRENVGIYNLS	NOMO1	606	Q15155
TVTYNGSICGDDQNG	LAMP2	71	P13473
DNGTYLCIAANAGGN	LINGO1	491	Q96FE5
AQGGEQAYLAGLAGQ	TUBGCP6	1411	Q96RT7
QVVSGESGYAQNGDL	IL7R	16	P16871
GDHNLSQNDGTEQYV	CELA1	76	Q9UNI1
QGQYEGLRGQDLGQA	LAMA5	2661	O15230
QLQELNVAYNGAGDT	NLRX1	836	Q86UT6
YVNGAQVATSGEQVG	PAPPA	211	Q13219
QTSQYGGDLTNTFGA	ITGA2	241	P17301
YQDGELQGSGENLAA	NPTXR	396	O95502
QSGAGGSDNDYLILN	ELAPOR2	476	A8MWY0
DAAQGAEGGTSQFQV	MIB1	321	Q86YT6
GGGLQSNELYALNEN	PRR5L	66	Q6MZQ0
QYFGQALSGGQDLTQ	ITGAD	581	Q13349
AAQQANGRSLYGQGL	OPN4	431	Q9UHM6
GLAVGNGLSSYEQND	CTSA	201	P10619
QNGGEGSYREAETFN	PAPPA2	241	Q9BXP8
NVGANGIGYQSNKEQ	CSGALNACT2	101	Q8N6G5
DGEDGALGQQQYLTR	CHD9	2371	Q3L8U1
NLGQDQLSQDGSGYE	CD19	426	P15391
SGNYSCEANNGLGAQ	FCRL1	271	Q96LA6
GVITDQNSDGYCQTG	DSP	46	P15924
NIELTGNGYNELTGQ	C7	136	P10643
QVSSISGGQSDQGYG	DENND4C	906	Q5VZ89
GQSISGQIDADNNGY	ITGA4	431	P13612
AAGGYDGQDQLNSVE	KEAP1	521	Q14145
QVTTSTGNQALYGGQ	KLF18	601	A0A0U1RQI7
GQNMTSTDNQALYGG	KLF18	866	A0A0U1RQI7
AVGGIDYNDTNQNAQ	FBXO30	246	Q8TB52
LYGDGAANQGQIAEA	PDHA2	191	P29803
VSTEGGNVYATGGNN	RPGR	101	Q92834
NYGQTSNGVADESPN	RGS7	6	P49802
HAGIDENYQAGGSEN	SPACA7	81	Q96KW9
EEGAAAYNGIGTATN	SNTB1	51	Q13884
GQQPSSGYQEENQGN	PRUNE2	1561	Q8WUY3
SGLGFNIVGGTDQQY	SYNJ2BP	21	P57105
NIVGGTDQQYVSNDS	SYNJ2BP	26	P57105
RGCSQNGQTYGNGET	KCP	136	Q6ZWJ8
HGADGNIQDEYGNTA	POTEB	191	A0A0A6YYL3
DFSNQNGTGGESIYG	PPID	86	Q08752
GSEIQGSNGETQGYV	MAPKAP1	51	Q9BPZ7
TDLYLAENNNGATGG	SIN3A	1021	Q96ST3
GGQYGAISALSINND	VPS8	196	Q8N3P4
TAVSNNAGVDNFGLG	OXCT1	86	P55809
SGEDTGPQDAQEYGN	HRC	606	P23327
SGDTGQQASVYIQGQ	PGBD1	126	Q96JS3
EAQSLVQGDYGALQS	POU3F2	36	P20265
QSNEKGGSYNSVVGA	NPAP1	476	Q9NZP6
NNYGCNGGSTLNALN	CTSO	166	P43234
YTQGANQSGQVFGLG	CNN2	251	Q99439
GQLSQFGASLYGQQS	CNOT2	66	Q9NZN8
ICSEFIYGGSQGNNN	WFDC6	101	Q9BQY6
ESVNAGANLQNYGET	UHRF1BP1L	1156	A0JNW5
EPANTDDNYGNSSGN	UBAP2L	206	Q14157
NLNGAYLTEGSNGEV	USP16	556	Q9Y5T5
GLTEGNVATINYTGQ	SLC27A3	426	Q5K4L6
YNQDSQDSIGEGVTQ	TPR	1886	P12270
LGEVAQGNENYAGIA	TLN1	1106	Q9Y490
AGQTSVYALDENGNL	TECPR1	1041	Q7Z6L1
NNSGEAGGAATQELF	ZNF574	296	Q6ZN55
DAQAAQQLQYGGAVG	TOLLIP	36	Q9H0E2
LSQGAGSYVVRNGEN	TCN1	411	P20061
SGNQALVYEGQLSQA	PRRC2B	2046	Q5JSZ5
VNAGSQYEGHNVGSN	TCF20	266	Q9UGU0
VENNSDNSGRYQGLE	TNFRSF13B	126	O14836
VDNLGASGNSLYQRN	TTC37	336	Q6PGP7
GQLLGQFTYDQDGES	SUN1	726	O94901
EQSGNDSNAYGNLYG	YIPF7	46	Q8N8F6
QGQGSHYGQTDRQGQ	RPTN	421	Q6XPR3
GQNSHYGQTDRQGQS	RPTN	446	Q6XPR3
QGQSSHYGQTDRQGQ	RPTN	541	Q6XPR3
LSEINGDAGSNYINA	PTPRC	696	P08575
NGYSNGQLGNHSEED	USP32	1481	Q8NFA0
QNDGIYETQANSATG	ZFYVE16	1296	Q7Z3T8
NQRQDYLNGAVSGSV	UBE2Q1	236	Q7Z7E8
NAAGGVEVYSGNQRI	ATP6V1E2	176	Q96A05
LEGAGGSSQNYQAAL	UNQ6493/PRO21345	56	Q6UXR8
QEGYSNSEAGSHQQL	LRIG2	866	O94898
QYADASIGNVTGSNA	SLC8A1	861	P32418