Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.04e-0820765GO:0061665
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.40e-0736765GO:0019789
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.30e-0650765GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.74e-0653765GO:0016859
GeneOntologyMolecularFunctioninterleukin-28 receptor binding

IFNL3 IFNL1

4.28e-053762GO:0032003
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 EVI5 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

9.26e-05279767GO:0005096
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD4 EVI5 RANBP2 RGPD8 GOPC RGPD3 RGPD1 SESN2 RGPD5

1.29e-04507769GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD4 EVI5 RANBP2 RGPD8 GOPC RGPD3 RGPD1 SESN2 RGPD5

1.29e-04507769GO:0030695
GeneOntologyMolecularFunctionbeta-glucosidase activity

KL LCTL

2.12e-046762GO:0008422
GeneOntologyMolecularFunctionclathrin light chain binding

CLTCL1 CLTC

2.97e-047762GO:0032051
GeneOntologyMolecularFunctionmolecular function activator activity

RGPD4 EVI5 RANBP2 KL RGPD8 RGPD3 RGPD1 OSGIN2 NLRC4 OSGIN1 IFNL3 RGPD5 IFNL1

7.13e-0412337613GO:0140677
GeneOntologyMolecularFunctionRNA polymerase II C-terminal domain binding

RPRD1A RPRD1B

7.69e-0411762GO:0099122
GeneOntologyMolecularFunctionisomerase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.29e-04192765GO:0016853
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD4 EVI5 RANBP2 RGPD8 RGPD3 RGPD1

1.40e-03321766GO:0031267
GeneOntologyMolecularFunctionglucosidase activity

KL LCTL

1.45e-0315762GO:0015926
GeneOntologyMolecularFunctionneurexin family protein binding

NLGN2 NLGN1

1.66e-0316762GO:0042043
GeneOntologyMolecularFunctionGTPase binding

RGPD4 EVI5 RANBP2 RGPD8 RGPD3 RGPD1

2.49e-03360766GO:0051020
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

7.40e-119765GO:0033133
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

7.61e-1120766GO:0006607
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.48e-1010765GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

7.47e-1013765GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-0914765GO:1903299
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD4 RANBP2 RGPD8 RGPD3 CLTC RGPD1 SESN2 PLCD1

2.97e-08132768GO:0043255
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

2.42e-0771766GO:0006111
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.71e-0738765GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.63e-0654765GO:0018208
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 CLTC RGPD1 SESN2 PLCD1

2.15e-06231768GO:0006109
GeneOntologyBiologicalProcessgluconeogenesis

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

3.41e-06111766GO:0006094
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD4 RANBP2 RGPD8 RGPD3 CLTC RGPD1 SESN2 PLCD1

3.53e-06247768GO:0016051
GeneOntologyBiologicalProcesscarbohydrate metabolic process

RGPD4 RANBP2 KL LCTL RGPD8 RGPD3 CLTC RGPD1 SESN2 PLCD1 HEXD B4GALT6

3.99e-066467612GO:0005975
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

4.19e-06115766GO:0019319
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

5.63e-06121766GO:0046364
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

1.01e-05134766GO:0010906
GeneOntologyBiologicalProcessregulation of small molecule metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2 PLCD1 FGFR4 PID1

3.05e-05434769GO:0062012
GeneOntologyBiologicalProcesspromoter clearance during DNA-templated transcription

RPRD1A RPRD1B

4.01e-053762GO:0001109
GeneOntologyBiologicalProcessRNA polymerase II promoter clearance

RPRD1A RPRD1B

4.01e-053762GO:0001111
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 SESN2 RGPD5

5.56e-05362768GO:0034504
GeneOntologyBiologicalProcesssynaptic vesicle recycling

ABCA13 CLTC NLGN2 NLGN1 PLD2

5.62e-05111765GO:0036465
GeneOntologyBiologicalProcessnuclear export

RGPD4 RANBP2 MDN1 RGPD8 RGPD3 RGPD1

6.24e-05185766GO:0051168
GeneOntologyBiologicalProcessneurotransmitter-gated ion channel clustering

CHRDL1 NLGN2 NLGN1

7.04e-0522763GO:0072578
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

8.34e-05195766GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

9.86e-05201766GO:0051170
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

RGPD4 RANBP2 ACOT8 RGPD8 RGPD3 RGPD1 SESN2 PLCD1 FGFR4 NLRC4

1.82e-046767610GO:0044283
GeneOntologyBiologicalProcessmRNA transport

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.98e-04145765GO:0051028
GeneOntologyBiologicalProcessglucose metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

2.82e-04244766GO:0006006
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

RGPD4 RANBP2 PDE4D RGPD8 RGPD3 RGPD1 SESN2 PLCD1 FGFR4 PID1 IFNL1

3.60e-048797611GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

RGPD4 RANBP2 PDE4D RGPD8 RGPD3 RGPD1 SESN2 PLCD1 FGFR4 PID1 IFNL1

3.60e-048797611GO:0010562
GeneOntologyBiologicalProcesspositive regulation of protein localization to synapse

NLGN2 NLGN1

3.70e-048762GO:1902474
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle clustering

NLGN2 NLGN1

3.70e-048762GO:2000809
GeneOntologyBiologicalProcesshyaluronan metabolic process

CLTC ITIH2 ITIH3

4.31e-0440763GO:0030212
GeneOntologyBiologicalProcesssynaptic vesicle endocytosis

ABCA13 CLTC NLGN2 NLGN1

4.37e-0496764GO:0048488
GeneOntologyBiologicalProcessRNA transport

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

4.72e-04175765GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

4.72e-04175765GO:0050657
GeneOntologyBiologicalProcessterminal button organization

NLGN2 NLGN1

4.74e-049762GO:0072553
GeneOntologyBiologicalProcessnuclear transport

RGPD4 RANBP2 MDN1 RGPD8 RGPD3 RGPD1 RGPD5

4.85e-04378767GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD4 RANBP2 MDN1 RGPD8 RGPD3 RGPD1 RGPD5

4.85e-04378767GO:0006913
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.10e-04178765GO:0051236
GeneOntologyBiologicalProcesspresynaptic endocytosis

ABCA13 CLTC NLGN2 NLGN1

5.50e-04102764GO:0140238
GeneOntologyBiologicalProcesspresynaptic membrane assembly

NLGN2 NLGN1

5.92e-0410762GO:0097105
GeneOntologyBiologicalProcesshexose metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

6.30e-04284766GO:0019318
GeneOntologyBiologicalProcesscellular response to type III interferon

IFNL3 IFNL1

7.21e-0411762GO:0071358
GeneOntologyBiologicalProcesspostsynaptic density protein 95 clustering

NLGN2 NLGN1

7.21e-0411762GO:0097119
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

NLGN2 NLGN1

7.21e-0411762GO:0097104
GeneOntologyBiologicalProcesstype III interferon-mediated signaling pathway

IFNL3 IFNL1

7.21e-0411762GO:0038196
GeneOntologyBiologicalProcesspositive regulation of kinase activity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2 FGFR4

7.29e-04405767GO:0033674
GeneOntologyBiologicalProcessregulation of synaptic vesicle clustering

NLGN2 NLGN1

8.63e-0412762GO:2000807
GeneOntologyBiologicalProcessmonosaccharide metabolic process

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SESN2

9.93e-04310766GO:0005996
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle endocytosis

ABCA13 NLGN1

1.02e-0313762GO:1900244
GeneOntologyBiologicalProcesspresynaptic membrane organization

NLGN2 NLGN1

1.02e-0313762GO:0097090
GeneOntologyBiologicalProcessresponse to type III interferon

IFNL3 IFNL1

1.02e-0313762GO:0034342
GeneOntologyBiologicalProcessintracellular transport

RGPD4 EVI5 RHBDD1 RANBP2 CLTCL1 MDN1 RGPD8 GOPC RGPD3 SYNE2 CLTC RGPD1 VPS13B RGPD5

1.02e-0314967614GO:0046907
GeneOntologyBiologicalProcesspostsynaptic membrane organization

CHRDL1 NLGN2 NLGN1

1.16e-0356763GO:0001941
GeneOntologyBiologicalProcessAMPA glutamate receptor clustering

CHRDL1 NLGN1

1.18e-0314762GO:0097113
GeneOntologyBiologicalProcessregulation of respiratory gaseous exchange by nervous system process

NLGN2 NLGN1

1.18e-0314762GO:0002087
GeneOntologyBiologicalProcessglutamate receptor clustering

CHRDL1 NLGN1

1.18e-0314762GO:0097688
GeneOntologyBiologicalProcessRNA localization

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.24e-03217765GO:0006403
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NLGN2 NLGN1

1.55e-0316762GO:0007158
GeneOntologyBiologicalProcessintracellular protein transport

RGPD4 RHBDD1 RANBP2 CLTCL1 RGPD8 RGPD3 CLTC RGPD1 RGPD5

1.56e-03740769GO:0006886
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle recycling

ABCA13 NLGN1

1.76e-0317762GO:1903423
GeneOntologyBiologicalProcessregulation of respiratory system process

NLGN2 NLGN1

1.76e-0317762GO:0044065
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.09e-118765GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.38e-1010765GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.08e-0914765GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

4.59e-0918765GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.26e-0920765GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.08e-0821765GO:0106068
GeneOntologyCellularComponentnuclear pore

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.82e-06101766GO:0005643
GeneOntologyCellularComponentinclusion body

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.92e-0590765GO:0016234
GeneOntologyCellularComponentinterleukin-28 receptor complex

IFNL3 IFNL1

1.30e-045762GO:0032002
GeneOntologyCellularComponenttrans-Golgi network transport vesicle

CLTCL1 GOPC CLTC

4.14e-0440763GO:0030140
GeneOntologyCellularComponentclathrin complex

CLTCL1 CLTC

4.62e-049762GO:0071439
GeneOntologyCellularComponentnuclear protein-containing complex

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 SYNE2 CLTC RGPD1 MED26 PDCD7 XAB2 SMAD9 RGPD5

1.29e-0313777613GO:0140513
GeneOntologyCellularComponenttranscription preinitiation complex

RPRD1A RPRD1B

1.33e-0315762GO:0097550
GeneOntologyCellularComponentGolgi-associated vesicle membrane

CLTCL1 GOPC CLTC

1.43e-0361763GO:0030660
GeneOntologyCellularComponentnuclear membrane

RGPD4 RANBP2 RGPD8 RGPD3 SYNE2 RGPD1

1.70e-03349766GO:0031965
GeneOntologyCellularComponentclathrin coat of trans-Golgi network vesicle

CLTCL1 CLTC

1.92e-0318762GO:0030130
MousePhenoabnormal morula morphology

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 RGPD1

4.82e-1026536MP:0012058
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.73e-0916535MP:0003701
MousePhenodecreased tumor latency

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.56e-0830535MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.02e-0731535MP:0012129
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 RGPD1 CDK11B

1.46e-07107537MP:0003694
MousePhenoabnormal tumor latency

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.65e-0734535MP:0010307
MousePhenoabnormal blastocyst hatching

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 RGPD1 CDK11B

2.12e-07113537MP:0003693
MousePhenoabnormal preimplantation embryo development

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 RGPD1 CDK11B XAB2

2.36e-07171538MP:0009781
MousePhenoincreased hepatocellular carcinoma incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

2.42e-0770536MP:0003331
MousePhenoabnormal rod electrophysiology

RGPD4 RANBP2 RGPD8 RGPD3 SYNE2 RGPD1 FSCN2

3.02e-07119537MP:0004021
MousePhenoabnormal blastocyst formation

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.37e-0739535MP:0012128
MousePhenoincreased sarcoma incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

2.26e-06102536MP:0002032
MousePhenoincreased lung tumor incidence

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SMAD9

2.99e-06107536MP:0008014
MousePhenoincreased respiratory system tumor incidence

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 SMAD9

2.99e-06107536MP:0010298
MousePhenoaneuploidy

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.27e-0661535MP:0004024
MousePhenoincreased liver tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

3.71e-06111536MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

3.71e-06111536MP:0010297
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 CDK11B XAB2

1.07e-05203537MP:0011094
MousePhenoincreased lung carcinoma incidence

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.11e-0578535MP:0008714
MousePhenoincreased organ/body region tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

1.54e-05395539MP:0010274
MousePhenoabnormal organ/body region tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

1.74e-05401539MP:0013152
MousePhenoabnormal chromosome number

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.78e-0586535MP:0004023
MousePhenoabnormal eye electrophysiology

RGPD4 RANBP2 RGPD8 RGPD3 SYNE2 RGPD1 FSCN2

2.28e-05228537MP:0005551
MousePhenoabnormal intracellular organelle morphology

RGPD4 DAP3 RHBDD1 RANBP2 RGPD8 RGPD3 SYNE2 RGPD1 SESN2 VPS13B

3.26e-055465310MP:0014239
MousePhenoembryonic lethality before implantation

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 CDK11B XAB2

3.34e-05242537MP:0006204
MousePhenoenlarged epididymis

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.53e-0599535MP:0004931
MousePhenoabnormal epididymis size

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 TDRD12

3.71e-05166536MP:0004926
MousePhenoabnormal cell nucleus morphology

RGPD4 RANBP2 RGPD8 RGPD3 SYNE2 RGPD1

6.58e-05184536MP:0003111
MousePhenoabnormal eye physiology

RGPD4 RANBP2 KL RGPD8 RGPD3 SYNE2 MAP3K14 RGPD1 FSCN2 VPS13B

7.85e-056065310MP:0005253
MousePhenoincreased classified tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 CDK11B SMAD9

8.58e-05381538MP:0010273
MousePhenoabnormal preimplantation embryo morphology

RGPD4 RANBP2 RGPD8 UTP4 RGPD3 RGPD1 PDCD7

8.99e-05283537MP:0014137
MousePhenoabnormal classified tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 CDK11B SMAD9

9.06e-05384538MP:0020188
MousePhenoincreased carcinoma incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

9.60e-05197536MP:0002038
MousePhenoabnormal chromosome morphology

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.12e-04126535MP:0003702
MousePhenoabnormal mitosis

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.20e-04128535MP:0004046
MousePhenoincreased tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

1.51e-04530539MP:0002020
MousePhenoincreased incidence of tumors by chemical induction

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.89e-04141535MP:0004499
MousePhenoincreased malignant tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1

2.63e-04237536MP:0002018
MousePhenodecreased susceptibility to diet-induced obesity

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.40e-04160535MP:0005659
MousePhenoincreased incidence of induced tumors

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

4.86e-04173535MP:0002021
MousePhenocortical cataract

LCTL VPS13B

4.99e-049532MP:0010255
MousePhenoabnormal epididymis morphology

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 TDRD12

5.16e-04269536MP:0002631
MousePhenoembryonic lethality prior to organogenesis, complete penetrance

RGPD4 RANBP2 RGPD8 FARS2 UTP4 RGPD3 RGPD1 CDK11B PDCD7 XAB2

5.57e-047725310MP:0014259
MousePhenoabnormal tumor incidence

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

5.74e-04635539MP:0002019
MousePhenoembryonic lethality prior to tooth bud stage, complete penetrance

RGPD4 RANBP2 RGPD8 FARS2 UTP4 RGPD3 RGPD1 CDK11B PDCD7 XAB2

5.98e-047795310MP:0014257
MousePhenodecreased susceptibility to weight gain

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

6.76e-04186535MP:0010182
MousePhenoabnormal tumor susceptibility

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

6.79e-04650539MP:0002166
MousePhenoincreased energy expenditure

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.56e-04196535MP:0004889
MousePhenoabnormal hepatobiliary system morphology

RGPD4 RHBDD1 RANBP2 KL FBXO4 RGPD8 ZBED6 RGPD3 MAP3K14 RGPD1 RHBDD3 SESN2 PDCD7 VPS13B

9.19e-0414765314MP:0002138
MousePhenoneoplasm

RGPD4 RANBP2 FBXO4 RGPD8 RGPD3 RGPD1 PLCD1 CDK11B SMAD9

1.81e-03747539MP:0002006
MousePhenoabnormal axillary lymph node morphology

MAP3K14 PLCD1

1.85e-0317532MP:0002340
DomainRan_BP1

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

3.65e-1212776PF00638
DomainRANBD1

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

3.65e-1212776PS50196
DomainRanBD

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

6.75e-1213776SM00160
DomainRan_bind_dom

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

6.75e-1213776IPR000156
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD1 RGPD5

4.73e-1011775SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD1 RGPD5

4.73e-1011775PF01465
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD1 RGPD5

8.08e-1012775IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD1 RGPD5

8.08e-1012775PS50913
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3 RGPD1

9.26e-097774IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3 RGPD1

9.26e-097774PF16704
Domain-

RGPD4 RGPD8 RGPD3 RGPD1

5.50e-08107741.10.220.60
DomainTPR-like_helical_dom

RGPD4 RANBP2 CLTCL1 RGPD8 RGPD3 CLTC RGPD1 XAB2 RGPD5

4.84e-07233779IPR011990
Domain-

RGPD4 RANBP2 CLTCL1 RGPD8 RGPD3 CLTC RGPD1 XAB2

2.17e-062077781.25.40.10
DomainTPR-contain_dom

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 XAB2 RGPD5

2.81e-06150777IPR013026
DomainTPR

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 XAB2

1.53e-05129776SM00028
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

1.68e-052772IPR022365
DomainClathrin-link

CLTCL1 CLTC

1.68e-052772PF09268
Domain-

CLTCL1 CLTC

1.68e-0527722.130.10.110
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

1.68e-052772IPR016025
DomainClathrin_propel

CLTCL1 CLTC

1.68e-052772PF01394
DomainClathrin_heavy_chain

CLTCL1 CLTC

1.68e-052772IPR016341
DomainOKL38_fam

OSGIN2 OSGIN1

1.68e-052772IPR029731
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

1.68e-052772IPR015348
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

1.68e-052772IPR001473
DomainTPR_repeat

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 XAB2

1.82e-05133776IPR019734
DomainClathrin_H-chain_linker

CLTCL1 CLTC

5.02e-053772IPR012331
DomainCREPT

RPRD1A RPRD1B

5.02e-053772IPR032337
DomainCLH

CLTCL1 CLTC

5.02e-053772SM00299
DomainCREPT

RPRD1A RPRD1B

5.02e-053772PF16566
DomainTPR_REGION

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

6.13e-05165776PS50293
DomainTPR

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

6.13e-05165776PS50005
DomainPH_dom-like

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 PLCD1 PLD2 PID1 RGPD5

6.28e-05426779IPR011993
DomainGlyco_hydro_1_N_CS

KL LCTL

1.00e-044772IPR033132
DomainINF_lambda

IFNL3 IFNL1

1.00e-044772IPR029177
DomainGlyco_hydro_1_AS

KL LCTL

1.00e-044772IPR018120
DomainIL28A

IFNL3 IFNL1

1.00e-044772PF15177
DomainNlgn

NLGN2 NLGN1

1.66e-045772IPR000460
DomainGLYCOSYL_HYDROL_F1_2

KL LCTL

1.66e-045772PS00653
DomainGLYCOSYL_HYDROL_F1_1

KL LCTL

1.66e-045772PS00572
DomainGlyco_hydro_1

KL LCTL

1.66e-045772PF00232
DomainGlyco_hydro_1

KL LCTL

1.66e-045772IPR001360
Domain-

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 PLCD1 PLD2 PID1

2.05e-043917782.30.29.30
DomainITI_HC_C

ITIH2 ITIH3

2.49e-046772IPR010600
DomainITI_HC_C

ITIH2 ITIH3

2.49e-046772PF06668
DomainRNA_pol_II-bd

RPRD1A RPRD1B

3.48e-047772IPR006903
DomainClathrin

CLTCL1 CLTC

3.48e-047772PF00637
DomainCTD_bind

RPRD1A RPRD1B

3.48e-047772PF04818
DomainCHCR

CLTCL1 CLTC

3.48e-047772PS50236
Domain-

KL LCTL HEXD

4.01e-04357733.20.20.80
DomainRPR

RPRD1A RPRD1B

4.62e-048772SM00582
DomainVIT

ITIH2 ITIH3

4.62e-048772PF08487
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

4.62e-048772IPR000547
DomainPeptidase_S54_rhomboid

RHBDD1 RHBDD3

4.62e-048772IPR002610
DomainVIT

ITIH2 ITIH3

4.62e-048772SM00609
DomainCID

RPRD1A RPRD1B

4.62e-048772PS51391
DomainCID_dom

RPRD1A RPRD1B

4.62e-048772IPR006569
DomainGlyco_hydro_catalytic_dom

KL LCTL HEXD

5.12e-0438773IPR013781
DomainTPR_1

RANBP2 RGPD8 RGPD1 RGPD5

5.22e-0490774PF00515
DomainTPR_1

RANBP2 RGPD8 RGPD1 RGPD5

5.22e-0490774IPR001440
DomainRhomboid

RHBDD1 RHBDD3

5.93e-049772PF01694
DomainPeptidase_S54_rhomboid_dom

RHBDD1 RHBDD3

5.93e-049772IPR022764
Domain-

RHBDD1 RHBDD3

5.93e-0497721.20.1540.10
DomainVIT

ITIH2 ITIH3

7.39e-0410772PS51468
DomainVIT

ITIH2 ITIH3

7.39e-0410772IPR013694
DomainCarboxylesterase_B_CS

NLGN2 NLGN1

1.27e-0313772IPR019819
DomainGlycoside_hydrolase_SF

KL LCTL HEXD

1.36e-0353773IPR017853
DomainCARBOXYLESTERASE_B_2

NLGN2 NLGN1

1.48e-0314772PS00941
DomainATPase_dyneun-rel_AAA

MDN1 DNAH1

1.48e-0314772IPR011704
DomainCOesterase

NLGN2 NLGN1

1.48e-0314772PF00135
DomainCarbesteraseB

NLGN2 NLGN1

1.48e-0314772IPR002018
DomainAAA_5

MDN1 DNAH1

1.48e-0314772PF07728
Domain-

MDN1 ITIH2 ITIH3

3.54e-03747733.40.50.410
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.13e-0918585MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-0740585MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

6.62e-0741585MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

7.49e-0742585MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

8.44e-0743585MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.33e-0647585MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.64e-0649585MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.82e-0650585MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.01e-0651585MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.94e-0655585MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.84e-0658585MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.84e-0658585MM14736
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

6.76e-0665585MM15147
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.20e-0573585MM14948
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.12e-0582585MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.38e-0584585MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.67e-0586585MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

3.70e-0592585MM14951
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.52e-05100585MM14561
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.03e-04114585MM15361
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.17e-04117585MM15387
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 PDCD7 XAB2

1.34e-04277587MM15414
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.84e-04129585MM14894
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.79e-04141585MM15266
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD4 RANBP2 RGPD8 GOPC RGPD3 RGPD1

6.34e-04257586MM14755
PathwayREACTOME_SUMOYLATION

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

6.40e-04169585MM14919
PathwayWP_TYPE_III_INTERFERON_SIGNALING

IFNL3 IFNL1

7.33e-0410582M39464
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RGPD4 RANBP2 RPRD1A RGPD8 RGPD3 MAMLD1 RGPD1 ZNF324 ZNF770 SESN2 ZNF850 RPRD1B

7.82e-0410225812MM15436
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 B4GALT6

8.36e-04271586MM15406
PathwayREACTOME_GAP_JUNCTION_DEGRADATION

CLTCL1 CLTC

1.07e-0312582M15243
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-03193585MM14890
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.42e-03202585MM15362
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777521205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777518949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777525187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-1377759037092
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-1377758603673
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD1 RGPD5

9.75e-13777515710750
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777526632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777524403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777523818861
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777511353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777530944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777538838144
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777523536549
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-1377757559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777517372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777538657106
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777512191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777522821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

9.75e-13777520682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.60e-12877522262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.60e-12877521670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.60e-12877528745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.60e-12877527412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.60e-12877521310149
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977518394993
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977511553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977510601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-1297759733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977528100513
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977528877029
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.83e-12977517887960
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-11107758857542
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-111077527160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-111077516332688
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.16e-111077521859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.13e-111177535771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.13e-111177517069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.13e-111177534110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

5.92e-111377531427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.38e-101577514697343
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.19e-092277527717094
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.21e-083877512791264
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RANBP2 RGPD8 RGPD5

4.17e-0847739480752
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD4 RANBP2 MDN1 RGPD8 RGPD3 RGPD1

1.20e-0615377626365490
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.41e-068677537253089
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

2.83e-069977527746211
Pubmed

Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis.

IFNL3 IFNL1

4.84e-06277229990995
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

4.84e-0627728733129
Pubmed

The Synergistic Effect of Fluvastatin and IFN-λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype.

IFNL3 IFNL1

4.84e-06277232245297
Pubmed

Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.

NLGN2 NLGN1

4.84e-06277210892652
Pubmed

Association Between IL28B, IL29 Gene Polymorphisms and Clinical Manifestations of Behçet's Disease.

IFNL3 IFNL1

4.84e-06277232646311
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

4.84e-06277229097553
Pubmed

FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease.

KL FGFR4

4.84e-06277234673637
Pubmed

NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.

NLGN2 NLGN1

4.84e-06277229278843
Pubmed

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.

IFNL3 IFNL1

4.84e-06277221800339
Pubmed

FGFR4 does not contribute to progression of chronic kidney disease.

KL FGFR4

4.84e-06277231575945
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

4.84e-06277220065094
Pubmed

Increased Serum Levels of IL-28 and IL-29 and the Protective Effect of IL28B rs8099917 Polymorphism in Patients with Hashimoto's Thyroiditis.

IFNL3 IFNL1

4.84e-06277227617784
Pubmed

Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin.

GOPC NLGN1

4.84e-06277216882988
Pubmed

Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.

NLGN2 NLGN1

4.84e-06277219889999
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.29e-0513577531077711
Pubmed

Interferon-λs: special immunomodulatory agents and potential therapeutic targets.

IFNL3 IFNL1

1.45e-05377223207147
Pubmed

Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration.

IFNL3 IFNL1

1.45e-05377229151074
Pubmed

Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.

NLGN2 NLGN1

1.45e-05377222960622
Pubmed

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

IFNL3 IFNL1

1.45e-05377226896692
Pubmed

Potential genetic markers for prediction of treatment response in Egyptian children infected with HCV genotype 4.

IFNL3 IFNL1

1.45e-05377225936570
Pubmed

Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model.

IFNL3 IFNL1

1.45e-05377215914836
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

1.45e-05377219509056
Pubmed

Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.

NLGN2 NLGN1

1.45e-05377228607166
Pubmed

Impact and regulation of lambda interferon response in human metapneumovirus infection.

IFNL3 IFNL1

1.45e-05377225355870
Pubmed

Full house: 12 receptors for 27 cytokines.

IFNL3 IFNL1

1.45e-05377215120645
Pubmed

ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer.

ITIH2 ITIH3

1.45e-05377214744536
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

1.45e-05377222891263
Pubmed

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.

KL FGFR4

1.45e-05377227457912
Pubmed

Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China.

IFNL3 IFNL1

1.45e-05377224269996
Pubmed

Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells.

IFNL3 IFNL1

1.45e-05377216539846
Pubmed

Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.

NLGN2 NLGN1

1.45e-05377227217145
Pubmed

SNX4 in complex with clathrin and dynein: implications for endosome movement.

CLTC DNAH1

1.45e-05377219529763
Pubmed

Type III interferon attenuates a vesicular stomatitis virus-based vaccine vector.

IFNL3 IFNL1

1.45e-05377225008938
Pubmed

Interleukin-28A enhances autoimmune disease in a retinal autoimmunity model.

IFNL3 IFNL1

1.45e-05377225138017
Pubmed

Interferon-lambda serum levels in hepatitis C.

IFNL3 IFNL1

1.45e-05377221145813
Pubmed

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.

NLGN2 NLGN1

1.45e-05377229100073
Pubmed

Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.

RANBP2 SYNE2

1.45e-05377236930595
Pubmed

Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.

ITIH2 ITIH3

1.45e-0537722476436
Pubmed

Induction of interferon lambda in influenza a virus infected cells treated with shRNAs against M1 transcript.

IFNL3 IFNL1

1.45e-05377226104331
Pubmed

Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory.

NLGN2 NLGN1

1.45e-05377227473321
Pubmed

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

CLTCL1 CLTC

1.45e-05377215133132
Pubmed

IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.

IFNL3 IFNL1

1.45e-05377231426334
Pubmed

Frequent methylation of the KLOTHO gene and overexpression of the FGFR4 receptor in invasive ductal carcinoma of the breast.

KL FGFR4

1.45e-05377226152288
Pubmed

Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.

ITIH2 ITIH3

1.45e-0537722446322
Pubmed

The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain.

ITIH2 ITIH3

1.45e-0537727534067
Pubmed

Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.

NLGN2 NLGN1

1.45e-05377226291161
Pubmed

Interleukin 28A aggravates Con A-induced acute liver injury by promoting the recruitment of M1 macrophages.

IFNL3 IFNL1

1.45e-05377238265281
Pubmed

Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells.

IFNL3 IFNL1

1.45e-05377216478884
Pubmed

Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses.

IFNL3 IFNL1

1.45e-05377219304895
Pubmed

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

IFNL3 IFNL1

1.45e-05377220060832
Pubmed

Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses.

NLGN2 NLGN1

1.45e-05377217897391
Pubmed

Neuroligins determine synapse maturation and function.

NLGN2 NLGN1

1.45e-05377216982420
Pubmed

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.

NLGN2 NLGN1

1.45e-05377217582332
Pubmed

Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection.

IFNL3 IFNL1

1.45e-05377233116245
InteractionRGPD4 interactions

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.81e-1022776int:RGPD4
InteractionRGPD1 interactions

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RPS6KA6 RGPD5

6.79e-1049777int:RGPD1
InteractionRGPD2 interactions

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

7.08e-1027776int:RGPD2
InteractionRGPD8 interactions

RGPD4 EVI5 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.32e-0874777int:RGPD8
InteractionRGPD3 interactions

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

2.42e-0847776int:RGPD3
InteractionNPIPB6 interactions

RANBP2 RGPD8 RGPD1 RGPD5

5.79e-0718774int:NPIPB6
InteractionRGPD5 interactions

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

1.80e-0696776int:RGPD5
InteractionKL interactions

KL LCTL FGFR4

1.89e-0514773int:KL
InteractionRANBP2 interactions

RGPD4 RHBDD1 RANBP2 RGPD8 RGPD3 CLTC RGPD1 RGPD5

7.04e-05361778int:RANBP2
InteractionNUP62 interactions

RANBP2 RGPD8 GOPC RGPD3 SYNE2 PDCD7 RGPD5

8.30e-05273777int:NUP62
InteractionRPS6KA6 interactions

RGPD1 RPS6KA6 FGFR4 OSGIN1

1.26e-0467774int:RPS6KA6
Cytoband2q13

RGPD8 RGPD3 RGPD5

2.10e-04687732q13
Cytoband19q13.13

IFNL3 IFNL1

2.87e-041577219q13.13
Cytoband2q12.3

RGPD4 RANBP2

3.72e-04177722q12.3
Cytoband2q36.3

RHBDD1 PID1

6.28e-04227722q36.3
Cytoband3p21.1

ITIH3 DNAH1

2.29e-03427723p21.1
Cytoband15q22.31

LCTL PDCD7

2.29e-034277215q22.31
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1 RGPD5

7.35e-07115506769
GeneFamilyRhomboid family

RHBDD1 RHBDD3

6.68e-0414502926
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

4.27e-0833775MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD4 RANBP2 RGPD8 RGPD3 RGPD1

1.69e-0743775MM3857
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RGPD4 RHBDD1 RANBP2 RGPD8 GOPC RGPD3 RGPD1 RPRD1B DNAH1 RGPD5

1.26e-064747710M40991
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_3DY_DN

RANBP2 PDE4D MDN1 NDUFAF5 RGPD8 CDK11B MED26 RPRD1B RGPD5

4.95e-06432779M41149
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN|PND01-03-samps / Age Group, Lineage, Cell class and subclass

TSGA13 RHBDD3 SESN2 NLGN1 ITIH3 DNAH1

1.42e-07137776a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 SYNE2 MAP3K14 PUM3 NLGN1 PID1

8.83e-07187776c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellmild-Myeloid-Immature_Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PDE4D CLTCL1 ABCA13 ZNF770 NDUFAF6 NLRC4

9.39e-0718977694dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

KLHL11 RANBP2 ZBED6 CLTC ZNF770 VPS13B

1.06e-06193776abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAP3K14 ZNF324 OSGIN2 PID1 B4GALT6

1.09e-051687754c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

PDE4D ABCA13 PUM3 NLGN1 PID1

1.87e-05188775ec38def1fdbb34ed9b30244806975bd5a4370164
DiseaseInflammatory Myofibroblastic Tumor

RANBP2 CLTC

8.51e-056712C0334121
Diseasenucleotide measurement

SYNE2 GRIK3 GTDC1

7.36e-0473713EFO_0010513
Diseasesphingomyelin 14:0 measurement

PDE4D SYNE2

7.58e-0417712EFO_0010390
Diseasehepatitis C (is_implicated_in)

IFNL3 IFNL1

2.07e-0328712DOID:1883 (is_implicated_in)
Diseaseresistin measurement

EVI5 XAB2

2.22e-0329712EFO_0004819

Protein segments in the cluster

PeptideGeneStartEntry
LGTALLPHQWQHKVH

ACOT8

236

O14734
QILKHPWVQAHSRRV

AURKC

286

Q9UQB9
HELHLNLLNHPWLVQ

FBXO4

346

Q9UKT5
DAQPHIQWLKHIVIN

FGFR4

276

P22455
KLWHHTLQVHQELRE

DUS1L

276

Q6P1R4
ILKLESLHQQPHIWD

ABCA13

166

Q86UQ4
LLRGVKHLHDNWILH

CDK11B

546

P21127
WLKQLFHHLPHETSR

RANBP2

456

P49792
PWAHDRKHHPRQLDK

RBM20

706

Q5T481
QEKHGLQPALLVHWA

RGPD5

566

Q99666
QEKHGLQPALLVHWA

RGPD8

566

O14715
LHIAEHPAGHLVLKW

PUM3

546

Q15397
LWNQLEAEIHLHRHK

GOPC

236

Q9HD26
LHWHWVLKHLVHQIP

MDN1

2746

Q9NU22
EPVLWRKDQHHHRVE

NLRC4

136

Q9NPP4
VLLHRVWKKHPVNVD

ITIH2

826

P19823
QLLDAAHHRHWPGVL

KIAA1109

4616

Q2LD37
AHLQRQVKPEAWLSH

CD1A

196

P06126
LEIRPFQVWLHHLDH

PID1

136

Q7Z2X4
HSLPALIQIRHDWDQ

PDCD7

436

Q8N8D1
VTLHHWDLPQLLQVK

LCTL

151

Q6UWM7
LKAPKHLWRHEQHHQ

PDE4D

26

Q08499
HQPVAIELWKAVKRH

NDUFAF6

131

Q330K2
HKGIPHHFRAIVWQL

EVI5

161

O60447
PPVEHHLRNHVQWLQ

HEXD

266

Q8WVB3
LLQDWHVILPRKHHR

PEDS1

201

A5PLL7
QILKHSWITHRDQLP

RPS6KA6

676

Q9UK32
NKVNLWLELVPHLHN

NLGN1

641

Q8N2Q7
LLRSWQKLIEPAHQH

MED26

76

O95402
ADAQHWVLGLHKIIH

PLCD1

116

P51178
VLHWKLEQHHYIPHV

OSGIN2

106

Q9Y236
QEKHGLQPALLVHWA

RGPD3

566

A6NKT7
HQPQRHWIKRGVALI

DNAH1

4246

Q9P2D7
RWVNLPHIHNHLDGH

KLHL11

386

Q9NVR0
WKVAVLIPFRNRHEH

B4GALT6

156

Q9UBX8
VHVWTIRKGILQHFH

CHRDL1

376

Q9BU40
LVDHVWHHPVRRNKF

AXDND1

96

Q5T1B0
LHHWLHRLQEAPKKE

IFNL1

146

Q8IU54
LHHWLHRLQEAPKKE

IFNL3

151

Q8IZI9
LPVPQWHHAHQLKAL

MAMLD1

296

Q13495
LVAHNLLLAHAKVWH

KL

266

Q9UEF7
NALEVPHIQLRWKHH

GRIK3

126

Q13003
PHIQLRWKHHPLDNK

GRIK3

131

Q13003
QRLLHIVWPHRWEHD

GTDC1

281

Q4AE62
WIAHSEKLPRKVLQH

SPACA9

151

Q96E40
NKVAFWLELVPHLHN

NLGN2

596

Q8NFZ4
VLTWKHRKEHAIPHV

OSGIN1

106

Q9UJX0
AQEKHGLQPALLVHW

RGPD1

556

P0DJD0
SPLQCLNHVWKLHHP

MAP3K14

231

Q99558
WTVHLAIHPQAHLLS

FSCN2

131

O14926
AKQDWLILHIPDAHL

DAP3

146

P51398
LAHRPWLITKEHIQA

SESN2

166

P58004
QWVRTKPFQHHTHDV

UTP4

276

Q969X6
QEKHGLQPALLVHWA

RGPD4

566

Q7Z3J3
NSVLLRQNPHHVHEW

XAB2

346

Q9HCS7
RQNPHHVHEWHKRVA

XAB2

351

Q9HCS7
LSLWLIHHRKHAGPI

RPRD1B

26

Q9NQG5
QQKDWQRLLLSPLHH

RHBDD1

61

Q8TEB9
WHRVHGMLNRKIQHL

SYNE2

5151

Q8WXH0
FAHHLPVWLHKLSVV

LMF2

216

Q9BU23
APHQIVAVGVHWNKH

TDRD12

606

Q587J7
VAVGVHWNKHIEHLI

TDRD12

611

Q587J7
VVLHQVWKKHPVHRD

ITIH3

776

Q06033
AIAHQLIKHWIRINP

NUDT12

446

Q9BQG2
LHWVNDLPRALEQIH

NDUFAF5

161

Q5TEU4
HLHGPLQWLDKVLTQ

SMAD9

441

O15198
IKRAVVHTHLLNPEW

CLTC

636

Q00610
IKRAVVHTHLLNPEW

CLTCL1

636

P53675
DPWQVHRLLTHALGH

RHBDD3

46

Q9Y3P4
SHHQHKPTENLWLPR

TSGA13

131

Q96PP4
HHRMGAVWQEPHRLL

ZNF324

221

O75467
IHHRKHSRPIVTVWE

RPRD1A

31

Q96P16
TAHHNWIHRIIPKLQ

PRSS27

266

Q9BQR3
KLEWQHIHQQPPHSK

SPATA31D1

476

Q6ZQQ2
TFRQAPHWKRHQLTH

ZNF770

661

Q6IQ21
LQRHLQATHPIHWAV

ZBED6

306

P86452
SILPKDLQAWVRAHH

ZSCAN16

91

Q9H4T2
HIHELRIHVPWTKLG

VPS13B

61

Q7Z7G8
RNLHNQQHHPLWLIK

FARS2

76

O95363
QQHHPLWLIKERVKE

FARS2

81

O95363
RHPDQVTLWAHHEKL

PLD2

431

O14939
AHLIQHWRIHTGDKP

ZNF850

266

A8MQ14