Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongamma-catenin binding

DSC3 PTPRJ PTPRT

1.48e-0512833GO:0045295
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1B FAT4 CELSR1 FAT2 DST DSC3 UMODL1 PLCH2 PCDHB12 DCHS1 LRP2 PPEF2

5.98e-057498312GO:0005509
GeneOntologyMolecularFunctionbeta-catenin binding

PTPRJ DCHS1 TBL1XR1 BTRC PTPRT

1.44e-04120835GO:0008013
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

LCK BTRC STAP1 FBXW7

1.95e-0469834GO:0045309
GeneOntologyMolecularFunctionnerve growth factor binding

SORT1 A2M

4.70e-048832GO:0048406
GeneOntologyMolecularFunctiongrowth factor binding

SORT1 GPC1 A2M CD109 LRP2

4.85e-04156835GO:0019838
GeneOntologyMolecularFunctiondelta-catenin binding

PTPRJ PTPRT

9.16e-0411832GO:0070097
GeneOntologyBiologicalProcesshomophilic cell adhesion via plasma membrane adhesion molecules

PRTG FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1 PTPRT

7.90e-07187828GO:0007156
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

PRTG FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1 SLITRK3 PTPRT

4.22e-06313829GO:0098742
GeneOntologyBiologicalProcessestablishment of planar polarity

FAT4 CELSR1 DCHS1 CPLANE1

2.79e-0544824GO:0001736
GeneOntologyBiologicalProcessestablishment of tissue polarity

FAT4 CELSR1 DCHS1 CPLANE1

3.05e-0545824GO:0007164
GeneOntologyBiologicalProcesscell-cell adhesion

CFH VMP1 PRTG FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1 COL14A1 UFL1 SLITRK3 LCK PTPRT

8.13e-0510778214GO:0098609
GeneOntologyBiologicalProcesscondensed mesenchymal cell proliferation

FAT4 DCHS1

9.32e-054822GO:0072137
DomainWD40_repeat_CS

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

2.90e-091648310IPR019775
Domain-

SORT1 NWD1 NWD2 EML5 TBL1Y WDR41 ARHGEF17 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

2.64e-0833383122.130.10.10
DomainWD40/YVTN_repeat-like_dom

SORT1 NWD1 NWD2 EML5 TBL1Y WDR41 ARHGEF17 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

2.82e-083358312IPR015943
DomainWD40_repeat_dom

NWD1 NWD2 EML5 TBL1Y WDR41 ARHGEF17 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

7.99e-082978311IPR017986
DomainWD40

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

3.03e-072688310SM00320
DomainWD40_repeat

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

3.47e-072728310IPR001680
DomainWD_REPEATS_1

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

4.24e-072788310PS00678
DomainWD_REPEATS_2

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

4.39e-072798310PS50082
DomainWD_REPEATS_REGION

NWD1 NWD2 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

4.39e-072798310PS50294
Domainfn3

PRTG PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

6.12e-07162838PF00041
DomainFN3

PRTG PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

1.67e-06185838SM00060
DomainWD40

NWD1 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

2.22e-06259839PF00400
DomainFN3

PRTG PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

2.87e-06199838PS50853
DomainFN3_dom

PRTG PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

4.13e-06209838IPR003961
DomainConA-like_dom

FAT4 CELSR1 FAT2 PTX3 CSPG4 FSD2 COL14A1 PTPRT

5.83e-06219838IPR013320
DomainLaminin_G

FAT4 CELSR1 FAT2 CSPG4 COL14A1

5.84e-0658835IPR001791
DomainCadherin_CS

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

9.01e-06109836IPR020894
DomainCADHERIN_1

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.11e-05113836PS00232
DomainCadherin

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.11e-05113836PF00028
DomainCADHERIN_2

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.17e-05114836PS50268
Domain-

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.17e-051148362.60.40.60
DomainCA

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.23e-05115836SM00112
DomainCadherin-like

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.29e-05116836IPR015919
DomainCadherin

FAT4 CELSR1 FAT2 DSC3 PCDHB12 DCHS1

1.42e-05118836IPR002126
DomainLAM_G_DOMAIN

FAT4 CELSR1 FAT2 CSPG4

2.39e-0538834PS50025
DomainLaminin_G_2

FAT4 CELSR1 FAT2 CSPG4

2.93e-0540834PF02210
DomainG-protein_beta_WD-40_rep

TBL1Y WDR41 TBL1XR1 BTRC FBXW7

3.81e-0585835IPR020472
DomainLamG

FAT4 CELSR1 FAT2 CSPG4

4.30e-0544834SM00282
Domain-

FAT4 CELSR1 FAT2 PTX3 CSPG4

6.50e-05958352.60.120.200
DomainEGF_CA

FAT4 CELSR1 FAT2 UMODL1 LRP2

2.12e-04122835SM00179
DomainEGF-like_Ca-bd_dom

FAT4 CELSR1 FAT2 UMODL1 LRP2

2.28e-04124835IPR001881
DomainThiol-ester_cl

A2M CD109

5.37e-048832PF10569
DomainMacrogloblnA2_thiol-ester-bond

A2M CD109

5.37e-048832IPR019565
DomainMacrogloblnA2_CS

A2M CD109

5.37e-048832IPR019742
DomainA2M_N_2

A2M CD109

5.37e-048832SM01359
Domain-

A2M CD109

5.37e-0488322.60.40.690
DomainA2M_recep

A2M CD109

5.37e-048832SM01361
DomainA2M

A2M CD109

5.37e-048832SM01360
DomainEGF_3

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

6.27e-04235836PS50026
DomainEGF

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

6.27e-04235836SM00181
DomainGrowth_fac_rcpt_

FAT4 CELSR1 UMODL1 TNN LRP2

6.55e-04156835IPR009030
DomainPtc/Disp

PTCHD1 DISP1

6.88e-049832IPR003392
DomainPatched

PTCHD1 DISP1

6.88e-049832PF02460
DomainLisH

TBL1Y TBL1XR1

6.88e-049832PF08513
DomainEGF-like_dom

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

8.47e-04249836IPR000742
DomainA2M_N

A2M CD109

8.58e-0410832PF01835
DomainSugar_P_trans_dom

SLC35E2A SLC35E2B

8.58e-0410832IPR004853
DomainA2M_N

A2M CD109

8.58e-0410832IPR002890
DomainA-macroglobulin_rcpt-bd

A2M CD109

8.58e-0410832IPR009048
DomainALPHA_2_MACROGLOBULIN

A2M CD109

8.58e-0410832PS00477
DomainA2M

A2M CD109

8.58e-0410832PF00207
DomainA2M_N_2

A2M CD109

8.58e-0410832IPR011625
DomainA2M_comp

A2M CD109

8.58e-0410832IPR011626
DomainA2M_N_2

A2M CD109

8.58e-0410832PF07703
DomainA2M_recep

A2M CD109

8.58e-0410832PF07677
DomainA2M_comp

A2M CD109

8.58e-0410832PF07678
DomainTPT

SLC35E2A SLC35E2B

8.58e-0410832PF03151
DomainMacroglobln_a2

A2M CD109

8.58e-0410832IPR001599
DomainEGF_1

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

9.58e-04255836PS00022
DomainASX_HYDROXYL

FAT4 CELSR1 UMODL1 LRP2

1.03e-03100834PS00010
DomainEGF-like_CS

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

1.08e-03261836IPR013032
DomainEGF_2

FAT4 CELSR1 FAT2 UMODL1 TNN LRP2

1.17e-03265836PS01186
Domain-

A2M CD109

1.25e-03128321.50.10.20
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT4 CELSR1 UMODL1 LRP2

1.28e-03106834IPR000152
DomainSSD

PTCHD1 DISP1

1.47e-0313832IPR000731
DomainSSD

PTCHD1 DISP1

1.47e-0313832PS50156
DomainQuinoprotein_ADH-like_supfam

NWD1 EML5 ERN1

1.69e-0353833IPR011047
DomainP_typ_ATPase_c

ATP9B ATP9A

1.72e-0314832IPR032630
DomainP-type_ATPase_N

ATP9B ATP9A

1.72e-0314832IPR032631
DomainP-type_ATPase_IV

ATP9B ATP9A

1.72e-0314832IPR006539
DomainPhoLip_ATPase_C

ATP9B ATP9A

1.72e-0314832PF16212
DomainPhoLip_ATPase_N

ATP9B ATP9A

1.72e-0314832PF16209
DomainGal_mutarotase_SF_dom

MAN2B2 GALM

2.54e-0317832IPR011013
Domain-

PRTG CD3D PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

2.68e-036638392.60.40.10
DomainTerpenoid_cyclase/PrenylTrfase

A2M CD109

2.85e-0318832IPR008930
Domain-

PHOSPHO2 ATP9B ATP9A

2.90e-03648333.40.50.1000
DomainApc4_WD40_dom

NWD1 EML5

3.52e-0320832IPR024977
DomainANAPC4_WD40

NWD1 EML5

3.52e-0320832PF12894
DomainIg-like_fold

PRTG CD3D PTPRJ UMODL1 TNN OBSL1 FSD2 COL14A1 PTPRT

4.06e-03706839IPR013783
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

FAT4 FAT2 DCHS1

4.90e-07785316059920
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

FAT4 CELSR1 DSC3 DCHS1 PRKDC

6.64e-076785521875946
Pubmed

Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.

FAT4 CELSR1 DCHS1

1.17e-06985328705793
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SORT1 GPC1 CFH VMP1 FAT4 CELSR1 B4GALNT1 MAN2B2 PTPRJ CSPG4 CD109 ST3GAL1 ATP9A GPR107

1.23e-061201851435696571
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

A2M CFH FAT2 PTPRJ TNN CSPG4 CD109

3.35e-0625785716335952
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

CD109 ST3GAL1 ATP9A WDFY4 PTPRT

5.10e-0610185518519826
Pubmed

SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.

SLC35E2A SLC35E2B

5.90e-06285235247439
Pubmed

Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation.

CFH PTX3

5.90e-06285219050261
Pubmed

Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration.

BTRC FBXW7

5.90e-06285236591289
Pubmed

Structure of the planar cell polarity cadherins Fat4 and Dachsous1.

FAT4 DCHS1

5.90e-06285236797229
Pubmed

Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.

FAT4 DCHS1

5.90e-06285225930014
Pubmed

Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.

FAT4 DCHS1

5.90e-06285225355906
Pubmed

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

PRKDC SIRT3

5.90e-06285231185214
Pubmed

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.

FAT4 FAT2 DCHS1

1.12e-051885333108146
Pubmed

C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation.

CFH PTX3

1.77e-05385229374201
Pubmed

ATF4 and IRE1α inhibit DNA repair protein DNA-dependent protein kinase 1 induced by heat shock.

ERN1 PRKDC

1.77e-05385223001845
Pubmed

Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.

CFH PTX3

1.77e-05385222786770
Pubmed

Asymmetry-defective oligodendrocyte progenitors are glioma precursors.

CSPG4 PRKDC

1.77e-05385221907924
Pubmed

Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells.

BTRC FBXW7

3.53e-05485234347919
Pubmed

Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.

CFH PTX3

3.53e-05485219632990
Pubmed

Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.

CD109 PRKDC

3.53e-05485222490868
Pubmed

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

PRKDC FBXW7

3.53e-05485220823234
Pubmed

Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells.

RNF128 BTRC

3.53e-05485231715145
Pubmed

Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.

TBL1Y TBL1XR1

5.87e-05585221459324
Pubmed

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

BTRC FBXW7

5.87e-05585220852628
Pubmed

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development.

FAT4 DCHS1

5.87e-05585224056717
Pubmed

Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs.

ATP9B ATP9A

5.87e-0558529548971
Pubmed

Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.

B4GALNT1 ST3GAL1

5.87e-05585217101770
Pubmed

Stratifin Inhibits SCFFBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis.

BTRC FBXW7

5.87e-05585230728155
Pubmed

A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages.

B4GALNT1 ERN1

5.87e-05585238520688
Pubmed

Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.

TBL1Y TBL1XR1

8.80e-05685228348241
Pubmed

Detection of sequential polyubiquitylation on a millisecond timescale.

BTRC FBXW7

8.80e-05685219956254
Pubmed

HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling.

CD3D LCK

8.80e-0568527774645
Pubmed

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex.

FAT4 DCHS1

8.80e-05685219506035
Pubmed

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.

BTRC FBXW7

1.23e-04785211735228
Pubmed

Identification of substrates for F-box proteins.

BTRC FBXW7

1.23e-04785216338364
Pubmed

Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.

BTRC FBXW7

1.23e-04785224811168
Pubmed

Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.

TBL1Y TBL1XR1

1.23e-04785227646874
Pubmed

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

BTRC FBXW7

1.23e-04785222307056
Pubmed

Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.

FAT4 DCHS1

1.23e-04785227145737
Pubmed

The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.

TBL1Y TBL1XR1

1.23e-04785215695367
Pubmed

LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.

BTRC FBXW7

1.64e-04885231152129
Pubmed

Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors.

BTRC FBXW7

1.64e-04885226474281
Pubmed

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.

TBL1Y TBL1XR1

1.64e-04885223770565
Pubmed

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.

TBL1Y TBL1XR1

1.64e-04885216127449
Pubmed

BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

BTRC FBXW7

1.64e-04885220558726
Pubmed

NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.

BTRC FBXW7

1.64e-04885232051583
Pubmed

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

BTRC FBXW7

1.64e-04885223453757
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

GPC1 A2M CACNA1B NWD2 UFL1 TBL1XR1 BTRC

1.67e-0447585731040226
Pubmed

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

BTRC FBXW7

2.10e-04985222017876
Pubmed

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

CFH PTX3

2.10e-04985228533443
Pubmed

SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.

BTRC FBXW7

2.10e-04985236828627
Pubmed

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

SORT1 NAA25 CYP17A1

2.25e-044885324262325
Pubmed

Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus.

TNN SLC39A4

2.62e-041085215065000
Pubmed

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.

BTRC FBXW7

2.62e-041085218765672
Pubmed

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.

ERN1 PRKDC

2.62e-041085225495526
Pubmed

Real-time resolution of point mutations that cause phenovariance in mice.

PRKDC LCK

2.62e-041085225605905
Pubmed

The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.

ATP9B ATP9A

2.62e-041085215919184
Pubmed

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.

TBL1Y TBL1XR1

2.62e-041085214980219
Pubmed

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

BTRC FBXW7

2.62e-041085231868589
Pubmed

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.

BTRC FBXW7

2.62e-041085231210753
Pubmed

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

BTRC FBXW7

2.62e-041085214603323
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

A2M FKBP15 PRKDC TBL1XR1

3.07e-0413185434551306
Pubmed

Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.

BTRC FBXW7

3.20e-041185225143387
Pubmed

Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.

FAT4 DCHS1

3.20e-041185226114487
Pubmed

Dchs1-Fat4 regulation of osteogenic differentiation in mouse.

FAT4 DCHS1

3.20e-041185231358536
Pubmed

Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.

BTRC FBXW7

3.20e-041185222975506
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

SLC35E2A PLCH2 SLC35E2B

3.56e-04568539455484
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

CFH MAN2B2 PTX3 CD109 COL14A1

3.65e-0424885524006456
Pubmed

Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity.

FAT4 DCHS1

3.83e-041285224998526
Pubmed

Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals.

A2M SLITRK3

3.83e-041285236577057
Pubmed

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

BTRC FBXW7

3.83e-041285218354482
Pubmed

HIV Nef: role in pathogenesis and viral fitness.

CD3D LCK

3.83e-041285218473783
Pubmed

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

ATP9B ATP9A

3.83e-041285221914794
Pubmed

Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.

SLC35E2A SLC35E2B TBL1XR1

3.94e-045885327869233
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

OR2K2 FAT4 SLC38A10 DST PCDHB12 LRP2 PRKDC ARHGEF17

4.45e-0473685829676528
Pubmed

HIV-1 Nef and T-cell activation: a history of contradictions.

CD3D LCK

4.52e-041385224187576
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP9B ATP9A

4.52e-041385211015572
Pubmed

Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.

BTRC FBXW7

4.52e-041385229499133
Pubmed

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.

BTRC FBXW7

4.52e-041385233962073
Pubmed

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.

BTRC FBXW7

5.27e-041485221070969
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

FKBP15 FAT2 EML5 ATP9B

5.39e-0415285434299191
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

PTPRJ PRKDC LCK TBL1XR1 DCAF7

5.93e-0427685528319085
Pubmed

Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.

PRKDC TBL1XR1

6.07e-041585217242407
Pubmed

Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.

LCK STAP1

6.07e-041585210679268
Pubmed

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

BTRC FBXW7

6.93e-041685222388891
Pubmed

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.

BTRC FBXW7

6.93e-041685229891922
Pubmed

Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.

FAT4 DCHS1

6.93e-041685227381226
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

CELSR1 FAT2 PCDHB12

7.44e-047285310380929
Pubmed

A perivascular niche for multipotent progenitors in the fetal testis.

CYP17A1 CSPG4

7.84e-041785230375389
Pubmed

Natural selection on the olfactory receptor gene family in humans and chimpanzees.

OR8J2 OR6M1

7.84e-041785212908129
Pubmed

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

FAT4 DCHS1

7.84e-041785232155439
Pubmed

HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

CD3D BTRC

7.84e-041785218541215
Pubmed

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

FAT4 BABAM1

7.84e-041785222153077
Pubmed

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

BTRC FBXW7

8.80e-041885228614300
Pubmed

Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.

GPC1 CSPG4

8.80e-041885212684764
Pubmed

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

CD3D PLCH2

8.80e-04188521979339
Pubmed

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

BTRC FBXW7

8.80e-041885215070733
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

CELSR1 FAT2 PCDHB12

9.04e-047785310835267
Pubmed

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.

CSPG4 FBXW7

9.83e-041985220935640
InteractionRYK interactions

PRTG FAT4 CELSR1 DST DSC3 CSPG4 DCHS1 PRKDC

2.89e-06212848int:RYK
GeneFamilyWD repeat domain containing

NWD1 EML5 TBL1Y WDR41 TBL1XR1 WDFY4 BTRC FBXW7 DCAF7

5.04e-07262679362
GeneFamilyFibronectin type III domain containing

PRTG PTPRJ TNN FSD2 COL14A1 PTPRT

2.79e-05160676555
GeneFamilyCadherin related

FAT4 FAT2 DCHS1

3.19e-051767324
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2M CD109

4.79e-0496721234
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

BTRC FBXW7

7.28e-0411672559
GeneFamilyATPase phospholipid transporting

ATP9B ATP9A

1.38e-03156721210
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRJ PTPRT

2.71e-0321672813
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNG6

4.15e-0326672253
ToppCellPosterior_cortex-Macroglia-ASTROCYTE-Gja1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M CELSR1 NWD1 PTX3 FSD2 GRIN2C

7.21e-08112846e30cd0b7b755c63081bbeed4e1a884b6640d34f8
ToppCellPosterior_cortex-Macroglia-ASTROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

A2M CELSR1 NWD1 PTX3 FSD2 GRIN2C

7.21e-081128461c0bcc6c972c50a9d950cd56b65efb8d778ec25a
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPC1 CFH CELSR1 FAT2 DSC3 PLCH2 PTPRT

9.44e-08197847107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCellCOVID-19_Severe-NK_CD56bright|COVID-19_Severe / disease group, cell group and cell class

FAT4 NWD1 CYP17A1 PLCH2 FSD2 LCK

5.74e-071598469e2067f0d76769717f7048dab505fadd36bbb83e
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D GALM ERN1 LCK

1.15e-06179846b0585a8e596c3d8e434af943e65207fa5877600d
ToppCellEpithelial-basal_cell|World / Lineage, Cell type, age group and donor

CFH CELSR1 FAT2 NWD1 DSC3 PLCH2

1.15e-06179846d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D GALM ERN1 LCK

1.48e-06187846f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH SFMBT1 CD3D GALM ERN1 LCK

1.52e-061888463e3055dacc05a932f2beb114babf1dc76994e1af
ToppCellCOPD-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

A2M CD3D GALM PTPRJ ST3GAL1 LCK

1.62e-0619084610bece40d980d37a01dae8ce887655bf9f93040c
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 FAT2 DSC3 PLCH2 CSPG4 CD109

1.67e-06191846ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

A2M CFH DST CSPG4 PCDHB12 COL14A1

1.67e-06191846e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D GALM ERN1 LCK

1.67e-06191846b9ef6d82b86271b7e0875a399bb9aae84ef5bad3
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

A2M CFH DST CSPG4 PCDHB12 COL14A1

1.67e-061918461726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D GALM ERN1 LCK

1.67e-061918464a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH PTX3 BTBD18 COL14A1 XPNPEP2

1.72e-061928462143e1fad2e88b90d668e12af37b2092d379090f
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.Dapl1_(Dapl1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FAT2 CYP17A1 CD109 XPNPEP2 OPN1SW

1.76e-061068457079111add27d7b3411dfe739280d62dc256a174
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Endothelial_Tip.Dcn.Dapl1_(Dapl1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FAT2 CYP17A1 CD109 XPNPEP2 OPN1SW

1.76e-06106845a6334b67be05f78145b57271b7959471b80bd67f
ToppCell21-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

A2M FAT4 DST CSPG4 PCDHB12 COL14A1

1.83e-061948468fc98d2c9d94f3bc6292265e20ab71c4f1f37bb3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPC1 CFH FAT2 DSC3 PLCH2 PTPRT

1.88e-061958466c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPC1 CFH CELSR1 FAT2 DSC3 PLCH2

1.94e-06196846c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCellCOPD-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

SFMBT1 VMP1 CD3D GALM ERN1 ST3GAL1

1.94e-06196846c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GPC1 A2M CFH CSPG4 ARHGEF17 RNF128

2.18e-06200846ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPC1 CELSR1 FAT2 NWD1 DSC3 PLCH2

2.18e-062008468827653738a931e4a4545e0c7d75be12bed40740
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D NWD2 TNN CD109 LRP2

4.79e-061308458c81853c806e9a0d562e00dc5e00a8fc569a854c
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D NWD2 TNN CD109 LRP2

4.79e-061308453041d20fe964d282d95c0312396f26bc93929056
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D NWD2 TNN CD109 LRP2

4.79e-061308453b6a8eaef593db73c2fad2260b9f1e15950ccb70
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CFH DMGDH B4GALNT1 DST UFL1

9.01e-06148845f90ee6fbd71b5e0512af34867202f38409f4de38
ToppCellAdult-Epithelial-basal_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH FAT2 NWD1 DSC3 PLCH2

1.09e-0515484538d346402417960044ae999e61f0092b46f2b591
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D CELSR1 GALM LCK TBL1XR1

1.44e-051638454af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D CELSR1 GALM LCK TBL1XR1

1.44e-05163845d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCellControl-Lymphocyte-T_NK-MAIT|Control / Disease, Lineage and Cell Type

CFH PRTG CD3D ERN1 LCK

1.71e-051698458c2aac193a9c500f01a99a2ee530839c851b6222
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPC1 CFH FAT2 DST DSC3

1.76e-051708450cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPC1 CFH FAT2 DST DSC3

1.76e-051708452d880223d01bde4bf777bd6f50b7d2768489075f
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

CFH CELSR1 FAT2 DSC3 PLCH2

1.81e-051718453965ced4be6db14265a90673502fceee425837ca
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D FAT2 GALM ERN1

1.81e-0517184561318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCellcellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPC1 FAT2 DST DSC3 CD109

1.86e-05172845e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

SORT1 TRANK1 PLCH2 ATP9A CREG1

1.92e-0517384542c911ed16fabdabef063830e8407192d8bde950
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

CD3D PLCH2 GRIN2C LCK ARHGEF17

1.97e-05174845390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D GALM ERN1 LCK

2.02e-05175845cc2428150987911d0d382e8177918724aa69f85c
ToppCellNS-moderate-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

A2M FAT4 B4GALNT1 CSPG4 DCHS1

2.02e-05175845f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D GALM ERN1 LCK

2.08e-05176845003076f1a983409ddf31b9c19e61c1facdd72566
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CFH CELSR1 FAT2 DSC3 PLCH2

2.14e-05177845cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPC1 A2M CFH FAT4 TNN

2.32e-05180845f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D ERN1 LCK

2.32e-0518084505f14cd367021891166825a8aac171227e2bcd97
ToppCelldroplet-Kidney-nan-3m-Hematologic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D B4GALNT1 FSD2 LCK DISP1

2.38e-0518184558d7e76dfaa818aeaef7f129c4472bf5b6563218
ToppCelldroplet-Kidney-nan-3m-Hematologic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D B4GALNT1 FSD2 LCK DISP1

2.38e-051818455d76e99bf2b5b337041efd3cd33bebbb0637b64e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

NWD1 GALM LRP2 XPNPEP2 PTPRT

2.38e-05181845c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCelldroplet-Kidney-nan-3m-Hematologic-leukocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD3D B4GALNT1 FSD2 LCK DISP1

2.38e-05181845970fc90e27236ee30190f1a02f418a378919c60b
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M CFH CD3D ERN1 LCK

2.44e-05182845f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCellCOVID-19_Severe-Lymphoid_T/NK-MAIT|COVID-19_Severe / Disease group, lineage and cell class

A2M CFH CD3D ERN1 LCK

2.44e-0518284519045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

A2M CFH CD3D ERN1 LCK

2.44e-05182845cccac9f85825f4e310b86e37ee6320769a670501
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FAT2 DSC3 PLCH2 HMGCS2

2.44e-05182845678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH FAT2 DSC3 PLCH2 HMGCS2

2.44e-051828458d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M CFH CD3D ERN1 LCK

2.44e-051828451444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

A2M CFH CD3D ERN1 LCK

2.44e-0518284549eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

GPC1 CACNA1B FAT2 B4GALNT1 DSC3

2.57e-05184845ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH DST PTX3 COL14A1

2.71e-051868455473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M PTCHD1 TNN CSPG4 ARHGEF17

2.78e-05187845d591a3c216997663ab77710fed0d230ffc37e41a
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M PTCHD1 TNN CSPG4 ARHGEF17

2.78e-05187845d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M PTCHD1 TNN CSPG4 ARHGEF17

2.78e-05187845ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

CELSR1 FAT2 DSC3 TBL1Y PLCH2

2.78e-051878458407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH SFMBT1 CD3D ERN1 LCK

2.85e-05188845fe08277d5aa693a2e12786738d12ec6390e8d13d
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

UMODL1 FSD2 WDFY4 STAP1

2.91e-05938441a112bd4e5e63826efad0338ce99d7a7ad9c72b9
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

UMODL1 FSD2 WDFY4 STAP1

2.91e-05938449c566fc2a8c7630bea28e8e46df55454aa409bc1
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

UMODL1 FSD2 WDFY4 STAP1

2.91e-0593844d102a0a015a2866e3fe549ac8796b9a0d5923d7e
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

UMODL1 FSD2 WDFY4 STAP1

2.91e-05938440967a93dcc72d2d8f12d56de186ec1af55c36001
ToppCellFrontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

UMODL1 FSD2 WDFY4 STAP1

2.91e-0593844613c827a643a7b6d70ef932cfa1762e90bc5a338
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

GPC1 FAT2 DSC3 PLCH2 CD109

2.93e-05189845533c302df467d13ab639232daf4f8cafb808260b
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

UMODL1 XPNPEP2 LCK STAP1 FBXW7

2.93e-0518984546c3f3dff71e7131a5ad1cd3b68709051a474c3c
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

CFH B4GALNT1 DST ERN1 CSPG4

3.00e-051908450c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M CFH CD3D GALM LCK

3.00e-0519084505e6af222d0ad97cb69f399a96c9038f9dd989b9
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_em|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D GALM ERN1 LCK

3.00e-051908451634a6044dce4e026a63976031a498c7460e3dce
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_em-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D GALM ERN1 LCK

3.00e-0519084508813c2f9321b82f0ec66854bb7a383aa1171780
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 DST EML5 COL14A1

3.08e-05191845c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH SFMBT1 CD3D ERN1 LCK

3.08e-05191845b53b490a8796e819edd3eb4a5a42b4499077b2d3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH CD3D GALM ERN1 LCK

3.08e-051918459c747f8cc1cdce45e839b661d782e1e8cfb79578
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 DST EML5 COL14A1

3.08e-05191845cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH PTX3 COL14A1 XPNPEP2

3.16e-05192845a8b7c539dc3037071bf068f372e4215563e11de4
ToppCellCOVID-19-lung-Secretory|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFH CELSR1 FAT2 DSC3 PLCH2

3.16e-0519284559261098ccb52306f837f632ebaea45b90ad30fe
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DMGDH CYP17A1 PLCH2 LRP2 XPNPEP2

3.16e-051928453e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH PTX3 COL14A1 XPNPEP2

3.16e-05192845904c003c4f73b1dfc8243cee02aad2676c515e50
ToppCellIPF-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

A2M CD3D GALM PTPRJ LCK

3.23e-051938453c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

A2M CFH FAT4 DST COL14A1

3.23e-05193845e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellnormal-na-Lymphocytic_T-T4_em|normal / PBMC cell types (v2) per disease, treatment status, and sex

CFH CD3D GALM ERN1 LCK

3.32e-05194845cc413fa7d24d0c821ec3a9f6a29ad50203d4fd0d
ToppCellBLOOD--(1)_MAIT-like_CD8_T_cells| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CFH CD3D GALM ERN1 LCK

3.32e-051948450064bcd9ac2fecec81f8d4e7d9f86f0089872fe7
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH CD3D GALM ERN1 LCK

3.40e-05195845c7b54b210cc2c8ddaefebfba74381adb2ca698b8
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFH CD3D GALM ERN1 LCK

3.40e-05195845e173a713d273b135db4f71bdcaada3b0e55d74f1
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CFH CD3D GALM ERN1 LCK

3.40e-0519584559164d115a0928cc9b79c7661c7190ad695f9d80
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFH CD3D GALM ERN1 LCK

3.40e-05195845a8fd42ff6c2bd80d0e3f20fe3bbf7d113b399df1
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH FAT4 TNN COL14A1

3.48e-0519684582fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

GPC1 FAT2 DST PLCH2 CD109

3.48e-051968453b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DMGDH CYP17A1 PLCH2 LRP2 XPNPEP2

3.48e-051968454ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT2 B4GALNT1 DSC3 PLCH2 PTPRT

3.48e-05196845a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

B4GALNT1 FSD2 MYEOV LCK STAP1

3.48e-051968451cc2b11764584129703ec61965e8ec4e051464e7
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CFH FAT4 TNN COL14A1

3.48e-0519684585e5046f774537684e1443c0fc147d562b7068d0
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPC1 FAT2 DST DSC3 PLCH2

3.48e-05196845e8db58e82300981f981402618a1befb91f6690fd
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPC1 FAT2 DST DSC3 PLCH2

3.48e-051968452cf42b702ea15adfa6bbd86a3c9613271863f86c
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

A2M CFH CD3D TRANK1 LCK

3.57e-05197845836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellSepsis-ICU-SEP-Myeloid-cDC1|ICU-SEP / Disease, condition lineage and cell class

DST OBSL1 WDR41 WDFY4 DISP1

3.57e-05197845e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CELSR1 SLC38A10 EML5 OBSL1 ST3GAL1

3.57e-051978451485933986921ff45669d9b7501c8d17050b3e97
Diseaseresponse to selective serotonin reuptake inhibitor, body mass index

GPC1 PLCH2 PTPRT

1.19e-068833EFO_0004340, EFO_0005658
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

A2M CFH LRP2

7.64e-0614833DOID:10976 (biomarker_via_orthology)
DiseaseVan Maldergem Wetzburger Verloes syndrome

FAT4 DCHS1

7.82e-062832C1832390
DiseaseVan Maldergem syndrome

FAT4 DCHS1

7.82e-062832cv:C1832390
DiseasePeriventricular gray matter heterotopia

FAT4 DCHS1

7.82e-062832C1849173
DiseaseHeterotopia, Periventricular, Autosomal Recessive

FAT4 DCHS1

2.34e-053832C1842563
Diseasesensory system disease (implicated_via_orthology)

TBL1Y TBL1XR1

2.34e-053832DOID:0050155 (implicated_via_orthology)
Diseaseuric acid measurement

SFMBT1 VMP1 FAT4 NAA25 RAB24 LRP2 MYEOV HMGCS2 XPNPEP2

5.49e-05610839EFO_0004761
Diseasecreatinine measurement

CFH SFMBT1 DMGDH RAB24 PTPRJ CSPG4 LRP2 FSD2 ATP9B MYEOV RNF128

1.07e-049958311EFO_0004518
Diseasepyridoxal kinase measurement

CFH HSF2BP

2.16e-048832EFO_0021919
Diseasetumor necrosis factor receptor superfamily member 19L measurement

CFH ARHGEF17

2.16e-048832EFO_0008309
DiseaseSevere Combined Immunodeficiency

CD3D PRKDC

1.44e-0320832C0085110
DiseaseCOVID-19 (is_implicated_in)

A2M CFH

1.59e-0321832DOID:0080600 (is_implicated_in)
Diseasenephrosis (biomarker_via_orthology)

CFH LRP2

1.74e-0322832DOID:2527 (biomarker_via_orthology)
Diseaseheel bone mineral density, urate measurement

PRTG ST3GAL1 MYEOV WDR41

1.76e-03182834EFO_0004531, EFO_0009270
DiseaseParkinson disease

CACNA1B PTCHD1 CYP17A1 WDR41 STAP1

2.15e-03321835MONDO_0005180
Diseasegout

SFMBT1 NAA25 DST LRP2

2.30e-03196834EFO_0004274
DiseaseL lactate dehydrogenase measurement

CFH PTPRJ

2.43e-0326832EFO_0004808
DiseaseSquamous cell carcinoma of esophagus

FAT4 FAT2 FBXW7

2.47e-0395833C0279626
DiseaseAdenocarcinoma of large intestine

PRKDC TBL1XR1 FBXW7

2.54e-0396833C1319315

Protein segments in the cluster

PeptideGeneStartEntry
VLETWNTSVTLSGLE

UMODL1

746

Q5DID0
ITWVEGTVGTLLSDI

CD3D

41

P04234
TVVLTVVEGWATLSV

CSPG4

111

Q6UVK1
TWDVAGEVTGVTLTG

B4GALNT1

186

Q00973
TVLVTGAKWLSVLEE

AACS

376

Q86V21
IITGSSDSTVRVWDV

BTRC

356

Q9Y297
GWTVSTDVTIFVTDI

FAT4

2851

Q6V0I7
GEWTTLPVCIVEEST

CFH

676

P08603
GESVVSWSDLNIIIS

CELSR1

1696

Q9NYQ6
VLWALLTLFTVSTGE

CACNA1B

1351

Q00975
GWELNVLESVTISVA

DISP1

1031

Q96F81
TLAVLSVGTEFWVEL

CACNG6

51

Q9BXT2
IDTTCTIWGLETGQV

DCAF7

141

P61962
VAEVGVTVPDTITEW

A2M

751

P01023
SILVWSVLDGTLLTV

NWD1

1456

Q149M9
SLSTSGVLSIWDIDI

NWD2

1291

Q9ULI1
SVGDRTVTLGIWDTA

RAB24

51

Q969Q5
IIESTEEGTTEYGLW

GPR107

386

Q5VW38
EELLWVGTSAGVVLT

ARHGEF17

1931

Q96PE2
TVSEVETTGRWELGG

OBSL1

1741

O75147
TGTITTTAILDREIW

DCHS1

2226

Q96JQ0
RVTVVSTTEIGLAWS

PTPRJ

461

Q12913
ESVIGSVHTWLAEAI

GPC1

311

P35052
VKEIGLESSTVWAST

DST

3336

Q03001
EVALVQWTESVGLTL

ATP9B

591

O43861
WDSVGRLEVGTETII

HMGCS2

121

P54868
ELFAIDSESGWITTL

FAT2

2846

Q9NYQ8
SEGVIGWTQATDSIL

FKBP15

266

Q5T1M5
VAGSWLTVVTVEALG

MYEOV

256

Q96EZ4
LRSETAEGIVVVTTW

METTL16

331

Q86W50
SDVWSFGILLTEIVT

LCK

421

P06239
SSIILTETIAIDWVG

LRP2

1506

P98164
VQWTESVGLTLVGRD

ATP9A

506

O75110
TATGNITIISLIWID

OR6M1

36

Q8NGM8
SVVVWSSGVDIISHL

PHOSPHO2

221

Q8TCD6
ILGSLVVTVSAWDLD

PCDHB12

256

Q9Y5F1
VVTEGWVKAELAIST

PTPRT

141

O14522
ITAATRVGLGESSVW

PRTG

591

Q2VWP7
LTWVTEFILVGVSDD

OR8J2

6

Q8NGG1
SNWVETGLEVSLTTD

BTBD18

631

B2RXH4
VDIISWGCTITALEV

GALM

31

Q96C23
SITSWVATGFVISED

CD109

716

Q6YHK3
LVVVNDDTAWLSGLT

BABAM1

146

Q9NWV8
GWITIDEISGSIITS

DSC3

516

Q14574
LLAAWTIGISKTVTE

CPLANE1

576

Q9H799
VVTVDSESGDVLWIQ

ERN1

206

O75460
IADIVILVDGSWSIG

COL14A1

156

Q05707
GAGVETTTSVVKWTL

CYP17A1

301

P05093
SGSLDTSIRVWDVET

FBXW7

556

Q969H0
VVLLEKSELTAGSTW

DMGDH

76

Q9UI17
SVVAVEERSLTGTWD

MAN2B2

946

Q9Y2E5
IWPVIGEVTDVTASC

EML5

1186

Q05BV3
SDWGALATISTLEAV

CREG1

66

O75629
WVGLGVLVVSTVTTL

SLC38A10

381

Q9HBR0
GVAVSWLTGAIAVLE

NHLRC1

266

Q6VVB1
GLITLSDWAAAVESV

PPEF2

586

O14830
TSLWVNGELAATTVE

PTX3

281

P26022
TVSWVTGCLTALLET

OR2K2

146

Q8NGT1
LTVVLATWTIGIGVS

OPN1SW

151

P03999
LWGVSSSEEVVKAIL

HSF2BP

131

O75031
WVGDSTGVILVLTTF

SORT1

116

Q99523
WITLTVVSVEFGVIG

PTCHD1

726

Q96NR3
WLTISEDGLTAVRSE

FSD2

576

A1L4K1
WIETISSVSVVGDVL

SLITRK3

576

O94933
VSEESEAWILAVATG

SLC39A4

581

Q6P5W5
TGVNRTVWELSEEGV

RNF128

56

Q8TEB7
TIDLEWVVSAITTGT

ST3GAL1

211

Q11201
VVHGVESLVELLGWT

SIRT3

366

Q9NTG7
TTVIESDLGVWSSRA

SLC35E2A

61

P0CK97
ILSAGVDKTTIIWDA

TBL1XR1

281

Q9BZK7
LATTDLAVLGTAWVT

TNN

346

Q9UQP3
EVLLWVGGSVVLSSE

PLCH2

21

O75038
TESGEEWRGFILTVT

STAP1

106

Q9ULZ2
AGSWVERSTEGVDIV

WDFY4

1666

Q6ZS81
TTVIESDLGVWSSRA

SLC35E2B

61

P0CK96
VLSAGVDKTTIIWDA

TBL1Y

291

Q9BQ87
VVEIVATILSWTGLA

PRKDC

2186

P78527
SLSTWIVTVVENIGG

SFMBT1

176

Q9UHJ3
VSITTNLVDLVWGSE

XPNPEP2

181

O43895
VQWLISIGASVETIG

TRANK1

186

O15050
ILTASADRTVIVWDG

WDR41

106

Q9HAD4
ASVEEAISSGTWVDI

UFL1

311

O94874
EEGTEGTISLWSIIS

VMP1

171

Q96GC9
ETGDETTVWQALTLL

NAA25

481

Q14CX7
TTVWQALTLLEEGLT

NAA25

486

Q14CX7
VGLISVVTESWRLSL

GRIN2C

271

Q14957