Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	growth factor binding	EGFR ITGB4 EPHA2 TWSG1	2.83e-05	156	23	4	GO:0019838
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM3 GRM7	4.55e-05	9	23	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM3 GRM7	4.55e-05	9	23	2	GO:0001640
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	8.32e-05	12	23	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	1.15e-04	14	23	2	GO:0097493
GeneOntologyMolecularFunction	glutamate receptor activity	GRM3 GRM7	4.38e-04	27	23	2	GO:0008066
GeneOntologyMolecularFunction	cell adhesion molecule binding	EGFR ITGB4 TENM2 EPHA2 FBN1	5.13e-04	599	23	5	GO:0050839
GeneOntologyMolecularFunction	integrin binding	EGFR ITGB4 FBN1	1.03e-03	175	23	3	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL18A1 FBN1 FBN2	1.27e-03	188	23	3	GO:0005201
GeneOntologyMolecularFunction	heparin binding	CRISPLD2 TWSG1 FBN1	1.35e-03	192	23	3	GO:0008201
GeneOntologyMolecularFunction	calcium channel regulator activity	GRM3 GRM7	1.75e-03	54	23	2	GO:0005246
GeneOntologyMolecularFunction	molecular function activator activity	EGFR GRN EPHA2 FBN1 FBN2 GNB5	2.22e-03	1233	23	6	GO:0140677
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EGFR EPHA2	2.53e-03	65	23	2	GO:0004714
GeneOntologyMolecularFunction	signaling receptor activator activity	EGFR GRN FBN1 FBN2	3.41e-03	554	23	4	GO:0030546
GeneOntologyMolecularFunction	glycosaminoglycan binding	CRISPLD2 TWSG1 FBN1	3.47e-03	268	23	3	GO:0005539
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EGFR EPHA2	4.28e-03	85	23	2	GO:0019199
GeneOntologyMolecularFunction	virus receptor activity	EGFR EPHA2	4.28e-03	85	23	2	GO:0001618
GeneOntologyMolecularFunction	exogenous protein binding	EGFR EPHA2	4.37e-03	86	23	2	GO:0140272
GeneOntologyMolecularFunction	signaling receptor regulator activity	EGFR GRN FBN1 FBN2	4.98e-03	616	23	4	GO:0030545
GeneOntologyMolecularFunction	sulfur compound binding	CRISPLD2 TWSG1 FBN1	5.84e-03	323	23	3	GO:1901681
GeneOntologyMolecularFunction	calcium ion binding	GRM7 TENM2 FBN1 FBN2	9.85e-03	749	23	4	GO:0005509
GeneOntologyMolecularFunction	hormone activity	FBN1 FBN2	1.05e-02	135	23	2	GO:0005179
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	7.13e-06	4	23	2	GO:0035583
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	3.32e-05	8	23	2	GO:0071694
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM3 GRM7	4.26e-05	9	23	2	GO:0007196
GeneOntologyBiologicalProcess	sequestering of extracellular ligand from receptor	FBN1 FBN2	6.50e-05	11	23	2	GO:0035581
GeneOntologyBiologicalProcess	extracellular regulation of signal transduction	FBN1 FBN2	9.21e-05	13	23	2	GO:1900115
GeneOntologyBiologicalProcess	extracellular negative regulation of signal transduction	FBN1 FBN2	9.21e-05	13	23	2	GO:1900116
GeneOntologyBiologicalProcess	cell adhesion mediated by integrin	ITGB4 EPHA2 FBN1	1.38e-04	91	23	3	GO:0033627
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM3 GRM7	1.41e-04	16	23	2	GO:0007216
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	GRM3 EGFR GRM7	1.43e-04	92	23	3	GO:0051966
GeneOntologyBiologicalProcess	embryo implantation	ITGB4 GRN FBN2	1.67e-04	97	23	3	GO:0007566
GeneOntologyBiologicalProcess	lung development	EGFR CRISPLD2 PHF14 FBN1	2.06e-04	269	23	4	GO:0030324
GeneOntologyBiologicalProcess	respiratory tube development	EGFR CRISPLD2 PHF14 FBN1	2.18e-04	273	23	4	GO:0030323
GeneOntologyBiologicalProcess	trophoblast cell migration	ITGB4 FBN2	2.23e-04	20	23	2	GO:0061450
GeneOntologyBiologicalProcess	notochord development	COL18A1 EPHA2	3.23e-04	24	23	2	GO:0030903
GeneOntologyBiologicalProcess	respiratory system development	EGFR CRISPLD2 PHF14 FBN1	3.32e-04	305	23	4	GO:0060541
GeneOntologyBiologicalProcess	ameboidal-type cell migration	ITGB4 COL18A1 GRN EPHA2 FBN2	3.73e-04	577	23	5	GO:0001667
GeneOntologyBiologicalProcess	synaptic transmission, glutamatergic	GRM3 EGFR GRM7	4.13e-04	132	23	3	GO:0035249
GeneOntologyBiologicalProcess	astrocyte activation	EGFR GRN	4.74e-04	29	23	2	GO:0048143
GeneOntologyBiologicalProcess	skeletal system development	COL18A1 EPHA2 TWSG1 FBN1 FBN2	4.99e-04	615	23	5	GO:0001501
GeneOntologyBiologicalProcess	tube development	EGFR CRISPLD2 COL18A1 PHF14 GRN EPHA2 FBN1	6.15e-04	1402	23	7	GO:0035295
GeneOntologyBiologicalProcess	glial cell development	EGFR ITGB4 GRN	6.85e-04	157	23	3	GO:0021782
GeneOntologyBiologicalProcess	skin development	SHARPIN EGFR ITGB4 EPHA2	7.10e-04	373	23	4	GO:0043588
GeneOntologyBiologicalProcess	embryo development	EGFR COL18A1 GRN EPHA2 TWSG1 KMT2D FBN2	7.13e-04	1437	23	7	GO:0009790
GeneOntologyBiologicalProcess	salivary gland morphogenesis	EGFR TWSG1	8.16e-04	38	23	2	GO:0007435
GeneOntologyBiologicalProcess	positive regulation of cell migration	EGFR COL18A1 TNFRSF18 GRN EPHA2	8.47e-04	691	23	5	GO:0030335
GeneOntologyBiologicalProcess	gland morphogenesis	EGFR EPHA2 TWSG1	9.86e-04	178	23	3	GO:0022612
GeneOntologyBiologicalProcess	salivary gland development	EGFR TWSG1	1.04e-03	43	23	2	GO:0007431
GeneOntologyBiologicalProcess	positive regulation of cell motility	EGFR COL18A1 TNFRSF18 GRN EPHA2	1.05e-03	725	23	5	GO:2000147
GeneOntologyBiologicalProcess	sensory organ development	EGFR OTOGL GRN EPHA2 TWSG1	1.08e-03	730	23	5	GO:0007423
GeneOntologyBiologicalProcess	camera-type eye development	EGFR GRN EPHA2 TWSG1	1.16e-03	426	23	4	GO:0043010
GeneOntologyBiologicalProcess	positive regulation of locomotion	EGFR COL18A1 TNFRSF18 GRN EPHA2	1.17e-03	742	23	5	GO:0040017
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta receptor signaling pathway	TWSG1 FBN1 FBN2	1.23e-03	192	23	3	GO:0017015
GeneOntologyBiologicalProcess	astrocyte development	EGFR GRN	1.25e-03	47	23	2	GO:0014002
GeneOntologyBiologicalProcess	regulation of cellular response to transforming growth factor beta stimulus	TWSG1 FBN1 FBN2	1.28e-03	195	23	3	GO:1903844
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	EGFR PHF14 EPHA2 TWSG1 FBN1 FBN2	1.54e-03	1186	23	6	GO:0007167
GeneOntologyBiologicalProcess	regulation of cell migration	EGFR COL18A1 TNFRSF18 GRN EPHA2 FBN2	1.72e-03	1211	23	6	GO:0030334
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	TWSG1 FBN1 FBN2	1.76e-03	218	23	3	GO:0090101
GeneOntologyBiologicalProcess	eye development	EGFR GRN EPHA2 TWSG1	1.80e-03	480	23	4	GO:0001654
GeneOntologyBiologicalProcess	exocrine system development	EGFR TWSG1	1.83e-03	57	23	2	GO:0035272
GeneOntologyBiologicalProcess	visual system development	EGFR GRN EPHA2 TWSG1	1.85e-03	483	23	4	GO:0150063
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	GRM3 GRM7	1.96e-03	59	23	2	GO:0007215
GeneOntologyBiologicalProcess	sensory system development	EGFR GRN EPHA2 TWSG1	1.96e-03	491	23	4	GO:0048880
GeneOntologyBiologicalProcess	animal organ morphogenesis	EGFR ITGB4 COL18A1 EPHA2 TWSG1 FBN2	2.18e-03	1269	23	6	GO:0009887
GeneOntologyBiologicalProcess	regulation of cell motility	EGFR COL18A1 TNFRSF18 GRN EPHA2 FBN2	2.28e-03	1280	23	6	GO:2000145
GeneOntologyCellularComponent	extracellular matrix	CRISPLD2 OTOGL ITGB4 COL18A1 FBN1 FBN2	5.97e-05	656	23	6	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	CRISPLD2 OTOGL ITGB4 COL18A1 FBN1 FBN2	6.07e-05	658	23	6	GO:0030312
GeneOntologyCellularComponent	postsynaptic membrane	GRM3 GRM7 ITGB4 TENM2 GNB5	6.72e-05	405	23	5	GO:0045211
GeneOntologyCellularComponent	microfibril	FBN1 FBN2	8.97e-05	13	23	2	GO:0001527
GeneOntologyCellularComponent	basement membrane	ITGB4 COL18A1 FBN1	3.15e-04	122	23	3	GO:0005604
GeneOntologyCellularComponent	synaptic membrane	GRM3 GRM7 ITGB4 TENM2 GNB5	3.68e-04	583	23	5	GO:0097060
GeneOntologyCellularComponent	glutamatergic synapse	GRM3 GRM7 ITGB4 TENM2 GRN	1.69e-03	817	23	5	GO:0098978
GeneOntologyCellularComponent	extrinsic component of membrane	TENM2 GML GNB5	1.98e-03	230	23	3	GO:0019898
GeneOntologyCellularComponent	cell leading edge	EGFR ITGB4 EPHA2 PEAR1	2.00e-03	500	23	4	GO:0031252
GeneOntologyCellularComponent	dendrite	GRM3 SHARPIN GRM7 TENM2 GNB5	2.09e-03	858	23	5	GO:0030425
GeneOntologyCellularComponent	dendritic tree	GRM3 SHARPIN GRM7 TENM2 GNB5	2.11e-03	860	23	5	GO:0097447
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ITGB4 COL18A1 FBN1 FBN2	2.47e-03	530	23	4	GO:0062023
GeneOntologyCellularComponent	presynaptic membrane	GRM3 GRM7 GNB5	3.35e-03	277	23	3	GO:0042734
GeneOntologyCellularComponent	receptor complex	EGFR GRM7 ITGB4 EPHA2	3.43e-03	581	23	4	GO:0043235
GeneOntologyCellularComponent	postsynapse	GRM3 GRM7 ITGB4 TENM2 GNB5	4.38e-03	1018	23	5	GO:0098794
GeneOntologyCellularComponent	vesicle lumen	EGFR CRISPLD2 GRN	5.55e-03	332	23	3	GO:0031983
GeneOntologyCellularComponent	excitatory synapse	GRN GNB5	6.12e-03	107	23	2	GO:0060076
GeneOntologyCellularComponent	ruffle membrane	EGFR EPHA2	6.23e-03	108	23	2	GO:0032587
GeneOntologyCellularComponent	cell surface	EGFR GRM7 ITGB4 TNFRSF18 EPHA2	6.34e-03	1111	23	5	GO:0009986
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	1.27e-05	3	11	2	HP:0012772
HumanPheno	Crumpled ear	FBN1 FBN2	6.33e-05	6	11	2	HP:0009901
HumanPheno	Lens dislocation	COL18A1 FBN1 FBN2	8.82e-05	43	11	3	HP:0000665
HumanPheno	Ectopia lentis	COL18A1 FBN1 FBN2	8.82e-05	43	11	3	HP:0001083
MousePheno	abnormal esophageal epithelium morphology	SHARPIN EGFR ITGB4	1.43e-06	17	19	3	MP:0000468
MousePheno	abnormal tongue epithelium morphology	SHARPIN EGFR ITGB4	6.10e-06	27	19	3	MP:0000764
MousePheno	subarachnoid hemorrhage	COL18A1 TWSG1	1.05e-05	4	19	2	MP:0031109
MousePheno	abnormal epidermis stratum basale morphology	SHARPIN EGFR ITGB4	1.61e-05	37	19	3	MP:0001231
MousePheno	abnormal nail morphology	EGFR ITGB4 FBN2	2.54e-05	43	19	3	MP:0000579
MousePheno	abnormal submandibular gland development	EGFR TWSG1	3.66e-05	7	19	2	MP:0013541
MousePheno	decreased respiration	EGFR ITGB4 PHF14 FBN1	7.10e-05	170	19	4	MP:0014274
MousePheno	abnormal ejaculation	GRM7 GRN	7.83e-05	10	19	2	MP:0001378
MousePheno	abnormal esophagus morphology	SHARPIN EGFR ITGB4	9.23e-05	66	19	3	MP:0000467
MousePheno	increased mast cell number	SHARPIN FBN1	1.15e-04	12	19	2	MP:0000324
MousePheno	enlarged cranium	COL18A1 FBN1	2.08e-04	16	19	2	MP:0000439
MousePheno	abnormal skin condition	SHARPIN EGFR ITGB4 FBN1	2.17e-04	227	19	4	MP:0001191
MousePheno	craniofacial phenotype	SHARPIN EGFR ITGB4 COL18A1 TWSG1 KMT2D FBN1 FBN2	2.37e-04	1372	19	8	MP:0005382
MousePheno	abnormal craniofacial morphology	SHARPIN EGFR ITGB4 COL18A1 TWSG1 KMT2D FBN1 FBN2	2.37e-04	1372	19	8	MP:0000428
MousePheno	abnormal pulmonary alveolus wall morphology	PHF14 FBN1	2.95e-04	19	19	2	MP:0010903
MousePheno	abnormal skin appearance	SHARPIN EGFR ITGB4 GRN FBN1	3.41e-04	473	19	5	MP:0009931
MousePheno	abnormal tongue morphology	SHARPIN EGFR ITGB4	5.15e-04	118	19	3	MP:0000762
MousePheno	abnormal maternal decidual layer morphology	EGFR FBN1	5.15e-04	25	19	2	MP:0004256
MousePheno	dilated kidney collecting duct	EGFR GRN	5.15e-04	25	19	2	MP:0004860
MousePheno	abnormal cranium morphology	EGFR COL18A1 TWSG1 KMT2D FBN1 FBN2	5.36e-04	813	19	6	MP:0000438
MousePheno	cardiac valve regurgitation	EGFR FBN1	5.58e-04	26	19	2	MP:0009384
MousePheno	abnormal submandibular gland morphology	EGFR TWSG1	5.58e-04	26	19	2	MP:0003793
MousePheno	abnormal jaw morphology	EGFR TWSG1 KMT2D FBN1 FBN2	5.75e-04	530	19	5	MP:0000454
MousePheno	abnormal craniofacial bone morphology	EGFR COL18A1 TWSG1 KMT2D FBN1 FBN2	5.87e-04	827	19	6	MP:0002116
MousePheno	abnormal lung interstitium morphology	SHARPIN EGFR	6.02e-04	27	19	2	MP:0002276
MousePheno	abnormal mast cell number	SHARPIN FBN1	6.02e-04	27	19	2	MP:0020203
MousePheno	abnormal heart valve physiology	EGFR FBN1	7.44e-04	30	19	2	MP:0011926
MousePheno	abnormal viscerocranium morphology	EGFR TWSG1 KMT2D FBN1 FBN2	9.57e-04	593	19	5	MP:0005274
MousePheno	abnormal platelet morphology	GRM7 GRN TWSG1 FBN1 FBN2	1.01e-03	600	19	5	MP:0004720
MousePheno	abnormal bronchiole morphology	EGFR FBN1	1.13e-03	37	19	2	MP:0002267
MousePheno	abnormal major salivary gland morphology	EGFR TWSG1	1.13e-03	37	19	2	MP:0003792
MousePheno	abnormal skeleton physiology	SHARPIN PHF14 TWSG1 FBN1 FBN2	1.27e-03	632	19	5	MP:0001533
MousePheno	abnormal cornea morphology	EGFR ITGB4 COL18A1 FBN2	1.31e-03	366	19	4	MP:0001312
MousePheno	abnormal heart valve morphology	EGFR COL18A1 FBN1	1.31e-03	163	19	3	MP:0000285
MousePheno	respiratory failure	EGFR ITGB4 PHF14	1.36e-03	165	19	3	MP:0001953
MousePheno	abnormal mast cell morphology	SHARPIN FBN1	1.46e-03	42	19	2	MP:0000359
Domain	EGF-like_CS	ITGB4 TENM2 EPHA2 FBN1 FBN2 PEAR1	3.20e-07	261	21	6	IPR013032
Domain	EGF_2	ITGB4 TENM2 EPHA2 FBN1 FBN2 PEAR1	3.50e-07	265	21	6	PS01186
Domain	FBN	FBN1 FBN2	3.61e-06	3	21	2	IPR011398
Domain	EGF_1	ITGB4 TENM2 FBN1 FBN2 PEAR1	7.76e-06	255	21	5	PS00022
Domain	Growth_fac_rcpt_	EGFR EPHA2 FBN1 FBN2	2.51e-05	156	21	4	IPR009030
Domain	TB	FBN1 FBN2	2.52e-05	7	21	2	PF00683
Domain	-	FBN1 FBN2	3.36e-05	8	21	2	3.90.290.10
Domain	GPCR_3_mtglu_rcpt	GRM3 GRM7	3.36e-05	8	21	2	IPR000162
Domain	TB	FBN1 FBN2	4.31e-05	9	21	2	PS51364
Domain	TB_dom	FBN1 FBN2	4.31e-05	9	21	2	IPR017878
Domain	NCD3G	GRM3 GRM7	9.32e-05	13	21	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM3 GRM7	9.32e-05	13	21	2	IPR011500
Domain	GPCR_3_CS	GRM3 GRM7	1.09e-04	14	21	2	IPR017979
Domain	EGF_3	TENM2 FBN1 FBN2 PEAR1	1.24e-04	235	21	4	PS50026
Domain	EGF	TENM2 FBN1 FBN2 PEAR1	1.24e-04	235	21	4	SM00181
Domain	EGF-like_dom	TENM2 FBN1 FBN2 PEAR1	1.54e-04	249	21	4	IPR000742
Domain	GPCR_3	GRM3 GRM7	2.50e-04	21	21	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM3 GRM7	2.74e-04	22	21	2	PS50259
Domain	EPHD	PHF14 KMT2D	2.74e-04	22	21	2	PS51805
Domain	7tm_3	GRM3 GRM7	2.74e-04	22	21	2	PF00003
Domain	GPCR_3_C	GRM3 GRM7	2.74e-04	22	21	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM3 GRM7	2.74e-04	22	21	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM3 GRM7	2.74e-04	22	21	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM3 GRM7	2.74e-04	22	21	2	PS00979
Domain	EGF_CA	TENM2 FBN1 FBN2	3.32e-04	122	21	3	SM00179
Domain	EGF-like_Ca-bd_dom	TENM2 FBN1 FBN2	3.48e-04	124	21	3	IPR001881
Domain	cEGF	FBN1 FBN2	3.85e-04	26	21	2	IPR026823
Domain	cEGF	FBN1 FBN2	3.85e-04	26	21	2	PF12662
Domain	Znf_FYVE_PHD	PHF14 KMT2D GNB5	5.73e-04	147	21	3	IPR011011
Domain	ANF_receptor	GRM3 GRM7	7.83e-04	37	21	2	PF01094
Domain	ANF_lig-bd_rcpt	GRM3 GRM7	7.83e-04	37	21	2	IPR001828
Domain	Peripla_BP_I	GRM3 GRM7	8.70e-04	39	21	2	IPR028082
Domain	PHD	PHF14 KMT2D	3.18e-03	75	21	2	PF00628
Domain	Znf_PHD-finger	PHF14 KMT2D	3.52e-03	79	21	2	IPR019787
Domain	EGF_CA	FBN1 FBN2	4.16e-03	86	21	2	PF07645
Domain	TyrKc	EGFR EPHA2	4.35e-03	88	21	2	SM00219
Domain	Tyr_kinase_cat_dom	EGFR EPHA2	4.35e-03	88	21	2	IPR020635
Domain	PHD	PHF14 KMT2D	4.45e-03	89	21	2	SM00249
Domain	Znf_PHD	PHF14 KMT2D	4.64e-03	91	21	2	IPR001965
Domain	ZF_PHD_2	PHF14 KMT2D	5.05e-03	95	21	2	PS50016
Domain	ZF_PHD_1	PHF14 KMT2D	5.15e-03	96	21	2	PS01359
Domain	PROTEIN_KINASE_TYR	EGFR EPHA2	5.26e-03	97	21	2	PS00109
Domain	EGF_Ca-bd_CS	FBN1 FBN2	5.26e-03	97	21	2	IPR018097
Domain	Tyr_kinase_AS	EGFR EPHA2	5.26e-03	97	21	2	IPR008266
Domain	EGF_CA	FBN1 FBN2	5.47e-03	99	21	2	PS01187
Domain	ASX_HYDROXYL	FBN1 FBN2	5.58e-03	100	21	2	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN1 FBN2	6.25e-03	106	21	2	IPR000152
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM3 GRM7	1.42e-04	15	17	2	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM3 GRM7	1.42e-04	15	17	2	MM15845
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ITGB4 COL18A1 FBN1 FBN2	2.16e-04	258	17	4	MM14572
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL18A1 FBN1 FBN2	3.22e-04	114	17	3	MM14571
Pathway	WP_HIPPOMERLIN_SIGNALING_DYSREGULATION	EGFR ITGB4 EPHA2	3.84e-04	121	17	3	M39823
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ITGB4 COL18A1 FBN1 FBN2	3.84e-04	300	17	4	M610
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	FBN1 FBN2	4.04e-04	25	17	2	M39713
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	EGFR EPHA2	4.04e-04	25	17	2	M47934
Pathway	PID_P53_DOWNSTREAM_PATHWAY	EGFR COL18A1 EPHA2	5.53e-04	137	17	3	M145
Pathway	REACTOME_LAMININ_INTERACTIONS	ITGB4 COL18A1	5.84e-04	30	17	2	M27216
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL18A1 FBN1 FBN2	5.89e-04	140	17	3	M587
Pathway	WP_PI3KAKT_SIGNALING	EGFR ITGB4 EPHA2 GNB5	6.10e-04	339	17	4	M39736
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2	6.65e-04	32	17	2	MM14854
Pathway	PID_ARF6_PATHWAY	EGFR EPHA2	7.96e-04	35	17	2	M86
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2	8.89e-04	37	17	2	M27134
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM3 GRM7	8.89e-04	37	17	2	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM3 GRM7	9.88e-04	39	17	2	M793
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2	9.88e-04	39	17	2	MM14601
Pathway	PID_ECADHERIN_STABILIZATION_PATHWAY	EGFR EPHA2	1.09e-03	41	17	2	M232
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2	1.26e-03	44	17	2	M26969
Pathway	WP_RAS_SIGNALING	EGFR EPHA2 GNB5	1.30e-03	184	17	3	M39764
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	EGFR ITGB4	1.37e-03	46	17	2	M239
Pathway	PID_TXA2PATHWAY	EGFR GNB5	2.03e-03	56	17	2	M99
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	COL18A1 FBN1 FBN2	5.54e-08	12	23	3	26405179
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	4.18e-07	2	23	2	12399449
Pubmed	Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer.	GRN EPHA2	4.18e-07	2	23	2	32417448
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	4.18e-07	2	23	2	21851253
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	4.18e-07	2	23	2	12429739
Pubmed	Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer.	EGFR EPHA2	4.18e-07	2	23	2	27401248
Pubmed	EphA2 is a functional receptor for the growth factor progranulin.	GRN EPHA2	4.18e-07	2	23	2	27903606
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	4.18e-07	2	23	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	4.18e-07	2	23	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	4.18e-07	2	23	2	15131124
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	4.18e-07	2	23	2	12524050
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	4.18e-07	2	23	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	4.18e-07	2	23	2	8791520
Pubmed	EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.	EGFR EPHA2	4.18e-07	2	23	2	21516087
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	4.18e-07	2	23	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	4.18e-07	2	23	2	35419902
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	4.18e-07	2	23	2	8307578
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	4.18e-07	2	23	2	10504303
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	4.18e-07	2	23	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	4.18e-07	2	23	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	4.18e-07	2	23	2	18006876
Pubmed	Cell adhesion and EGFR activation regulate EphA2 expression in cancer.	EGFR EPHA2	4.18e-07	2	23	2	19948216
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	4.18e-07	2	23	2	24833718
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	4.18e-07	2	23	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	4.18e-07	2	23	2	20529844
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	4.18e-07	2	23	2	25524144
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	4.18e-07	2	23	2	23133647
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	4.18e-07	2	23	2	16407178
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	4.18e-07	2	23	2	1852206
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	4.18e-07	2	23	2	10359653
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EGFR ITGB4 COL18A1 GRN EPHA2 TWSG1 FBN1 FBN2	6.10e-07	1201	23	8	35696571
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	1.25e-06	3	23	2	10825173
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	1.25e-06	3	23	2	30201140
Pubmed	Progranulin expression in breast cancer with different intrinsic subtypes.	EGFR GRN	1.25e-06	3	23	2	22397762
Pubmed	An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer.	EGFR ITGB4	1.25e-06	3	23	2	26549523
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	1.25e-06	3	23	2	20855508
Pubmed	A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population.	COL18A1 FBN1	2.51e-06	4	23	2	21527992
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	2.51e-06	4	23	2	12429738
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	2.51e-06	4	23	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	2.51e-06	4	23	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	2.51e-06	4	23	2	25034023
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	2.51e-06	4	23	2	16835936
Pubmed	N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.	EGFR ITGB4	2.51e-06	4	23	2	27641064
Pubmed	Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.	EGFR FBN2	2.51e-06	4	23	2	19469909
Pubmed	An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway.	EGFR ITGB4	2.51e-06	4	23	2	26996299
Pubmed	Integrin α6β4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF).	EGFR ITGB4	2.51e-06	4	23	2	26381405
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	4.18e-06	5	23	2	26601954
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	4.18e-06	5	23	2	12590922
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	4.18e-06	5	23	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	4.18e-06	5	23	2	34411563
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	4.18e-06	5	23	2	23493297
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	COL18A1 FBN1 FBN2	4.85e-06	50	23	3	23658023
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	GRN KMT2D FBN1 FBN2	6.21e-06	184	23	4	32908313
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	6.26e-06	6	23	2	7873879
Pubmed	Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit.	EGFR ITGB4	6.26e-06	6	23	2	9022052
Pubmed	Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.	EGFR ITGB4 EPHA2	6.48e-06	55	23	3	38945485
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	8.77e-06	7	23	2	11470817
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM3 GRM7	8.77e-06	7	23	2	9920659
Pubmed	Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.	EGFR ITGB4	1.17e-05	8	23	2	26350464
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	1.17e-05	8	23	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	1.17e-05	8	23	2	31201465
Pubmed	Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.	EGFR ITGB4	1.17e-05	8	23	2	25202019
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	1.17e-05	8	23	2	18339631
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2	1.50e-05	9	23	2	12122015
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	1.50e-05	9	23	2	38844137
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	EGFR ITGB4 EPHA2	1.65e-05	75	23	3	15951569
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	1.88e-05	10	23	2	30738849
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM3 GRM7	1.88e-05	10	23	2	9069281
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	GRM3 GRM7	1.88e-05	10	23	2	17156446
Pubmed	Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.	ITGB4 COL18A1	2.29e-05	11	23	2	17023412
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	2.75e-05	12	23	2	36779913
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRM3 GRM7	2.75e-05	12	23	2	11891216
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	EGFR GRM7 ITGB4	4.04e-05	101	23	3	23382219
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 FBN2	6.36e-05	18	23	2	35503090
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	FBN1 FBN2	6.36e-05	18	23	2	39040056
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	COL18A1 FBN1 FBN2	9.57e-05	135	23	3	28675934
Pubmed	Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.	EGFR EPHA2	9.59e-05	22	23	2	15657067
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM3 GRM7	1.14e-04	24	23	2	35746896
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	EGFR EPHA2	1.24e-04	25	23	2	15254900
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN1 FBN2	1.35e-04	26	23	2	34189436
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	FBN1 FBN2	1.80e-04	30	23	2	32882513
Pubmed	Heritable Thoracic Aortic Disease Overview	FBN1 FBN2	1.80e-04	30	23	2	20301299
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	GRN FBN1	1.92e-04	31	23	2	31550482
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	FBN1 FBN2	1.92e-04	31	23	2	25762570
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL18A1 FBN1 FBN2	2.06e-04	175	23	3	28071719
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	FBN1 FBN2	2.60e-04	36	23	2	35167946
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	FBN1 FBN2	2.75e-04	37	23	2	34323105
Pubmed	Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.	COL18A1 FBN1 FBN2	2.87e-04	196	23	3	19334288
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	GRM3 GRM7	2.90e-04	38	23	2	25613138
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	EGFR EPHA2	3.21e-04	40	23	2	30898150
Pubmed	Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.	FBN1 FBN2	3.21e-04	40	23	2	30578393
Pubmed	Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.	GRM3 GRM7 GNB5	3.77e-04	215	23	3	36808153
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRM3 GRM7	4.07e-04	45	23	2	25979088
Pubmed	Congenital Diaphragmatic Hernia Overview	KMT2D FBN1	4.25e-04	46	23	2	20301533
Pubmed	Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration.	EGFR EPHA2	4.25e-04	46	23	2	35022314
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	FBN1 FBN2	5.44e-04	52	23	2	30389913
Pubmed	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	GRM3 GRM7	5.44e-04	52	23	2	19328558
Pubmed	Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.	EGFR FBN2	5.65e-04	53	23	2	33153107
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	COL18A1 GRN FBN1	5.71e-04	248	23	3	24006456
Pubmed	Claudin-4 localization in epithelial ovarian cancer.	EGFR EPHA2	5.86e-04	54	23	2	36237976
Interaction	GRM4 interactions	GRM3 EGFR GRM7	2.13e-07	11	23	3	int:GRM4
Interaction	MFAP5 interactions	GRN FBN1 FBN2	2.77e-05	52	23	3	int:MFAP5
Interaction	NISCH interactions	FAM219B SHARPIN EGFR EPHA2	3.01e-05	160	23	4	int:NISCH
Interaction	ZFP41 interactions	GRN FBN1 FBN2	3.65e-05	57	23	3	int:ZFP41
Interaction	HRG interactions	GRN FBN1 FBN2	4.93e-05	63	23	3	int:HRG
Interaction	FBN2 interactions	EGFR FBN1 FBN2	5.42e-05	65	23	3	int:FBN2
Interaction	ITGA3 interactions	EGFR ITGB4 EPHA2	6.20e-05	68	23	3	int:ITGA3
Interaction	MFAP2 interactions	FBN1 FBN2	8.17e-05	12	23	2	int:MFAP2
Interaction	FBXO2 interactions	EGFR COL18A1 GRN FBN1 FBN2	8.56e-05	411	23	5	int:FBXO2
Interaction	ADAMTSL1 interactions	GRN FBN2	9.64e-05	13	23	2	int:ADAMTSL1
Interaction	VOPP1 interactions	EGFR EPHA2	9.64e-05	13	23	2	int:VOPP1
Interaction	KRTAP15-1 interactions	EGFR ITGB4 GRN	1.05e-04	81	23	3	int:KRTAP15-1
Cytoband	8q24.3	SHARPIN GML	1.47e-03	113	23	2	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	FBN1 GNB5	3.55e-03	177	23	2	chr15q21
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	ITGB4 OXLD1	1.03e-02	307	23	2	chr17q25
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	SHARPIN GML	1.36e-02	355	23	2	chr8q24
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM3 GRM7	1.13e-05	8	12	2	281
GeneFamily	PHD finger proteins	PHF14 KMT2D	1.57e-03	90	12	2	88
GeneFamily	Fibronectin type III domain containing	ITGB4 EPHA2	4.85e-03	160	12	2	555
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ITGB4 TNFRSF18	2.71e-02	394	12	2	471
Coexpression	NABA_CORE_MATRISOME	CRISPLD2 OTOGL COL18A1 FBN1 FBN2	3.23e-06	270	23	5	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	CRISPLD2 OTOGL FBN1 FBN2	2.17e-05	191	23	4	MM17059
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HPERIC	GRM3 CRISPLD2 COL18A1 GRN EPHA2 FBN1	4.96e-05	795	23	6	M39050
Coexpression	NABA_CORE_MATRISOME	CRISPLD2 COL18A1 FBN1 FBN2	8.97e-05	275	23	4	M5884
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_500	GRM3 EGFR CRISPLD2 GRM7 TENM2 TWSG1	3.71e-06	408	23	6	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_200	GRM3 EGFR CRISPLD2 TENM2	2.77e-05	165	23	4	gudmap_developingLowerUrinaryTract_e14.5_ urethra_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	GRM3 EGFR CRISPLD2 GRM7 TENM2 TWSG1	1.70e-04	806	23	6	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_200	CRISPLD2 TENM2	1.90e-04	19	23	2	gudmap_developingLowerUrinaryTract_e14.5_ urethra_200_k5
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_1000	GRM3 EGFR FBN1 FBN2	2.39e-04	288	23	4	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k5
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500	EGFR FBN1 FBN2	3.01e-04	122	23	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM3 CRISPLD2 GRM7 FBN1 FBN2	3.53e-08	185	23	5	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM3 CRISPLD2 GRM7 FBN1 FBN2	3.53e-08	185	23	5	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM3 CRISPLD2 GRM7 FBN1 FBN2	3.62e-08	186	23	5	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 COL18A1 FBN1 FBN2	1.61e-06	169	23	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EGFR CRISPLD2 COL18A1 FBN2	1.81e-06	174	23	4	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRISPLD2 OTOGL COL18A1 PEAR1	2.02e-06	179	23	4	dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 COL18A1 FBN1 PEAR1	2.07e-06	180	23	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 OTOGL COL18A1 PEAR1	2.26e-06	184	23	4	89ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 OTOGL COL18A1 PEAR1	2.26e-06	184	23	4	34c84ac9a32eaf96f45b79485119cad65905817d
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGB4 COL18A1 EPHA2 FBN1	2.35e-06	186	23	4	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	facs-BAT-Fat-18m-Mesenchymal\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 COL18A1 FBN1	2.51e-06	189	23	4	bba28f57a0708515fdd5acd9592dbbe4a4f57116
ToppCell	facs-BAT-Fat-18m-Mesenchymal-mesenchymal_progenitor\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 COL18A1 FBN1	2.51e-06	189	23	4	cf293b23a4c0e8a0c9f09115b1d53d9b11de72e2
ToppCell	facs-BAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 COL18A1 FBN1	2.51e-06	189	23	4	87323e86a5b5d159920a07e6bd7ef5e3438cd085
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EGFR CRISPLD2 TWSG1 FBN1	2.62e-06	191	23	4	997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCell	facs-Lung-3m-Mesenchymal\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EGFR CRISPLD2 TWSG1 FBN1	2.67e-06	192	23	4	8df15085b35b86f39debd933284cb703c5dd63c2
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	2.67e-06	192	23	4	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	2.67e-06	192	23	4	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	LA\|World / Chamber and Cluster_Paper	EGFR CRISPLD2 FBN1 GNB5	2.73e-06	193	23	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	2.73e-06	193	23	4	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	droplet-Heart-nan-3m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	2.78e-06	194	23	4	ce32e60bcea1b8baf496ce9050832bc8c77d8434
ToppCell	LA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	EGFR CRISPLD2 COL18A1 FBN1	2.78e-06	194	23	4	803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell	droplet-Heart-nan-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	2.78e-06	194	23	4	a1dc157148885cc8d3685ac81a1f4e3562aeecc9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRM3 COL18A1 FBN1 PEAR1	2.90e-06	196	23	4	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR ITGB4 TENM2 EPHA2	2.90e-06	196	23	4	c5adab88140a465698abcbedc6505a43cae7bfd1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRM3 COL18A1 FBN1 PEAR1	2.90e-06	196	23	4	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	PND28-Mesenchymal\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 COL18A1 TWSG1 FBN1	2.90e-06	196	23	4	119265efd2219f328d8152dbee52af8327aec89c
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TENM2 FBN1 FBN2 PEAR1	2.96e-06	197	23	4	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR ITGB4 TENM2 EPHA2	2.96e-06	197	23	4	de772bd2b4cda843777ac879b1087e6444199dfb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGFR CRISPLD2 COL18A1 FBN1	2.96e-06	197	23	4	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EGFR CRISPLD2 COL18A1 FBN1	2.96e-06	197	23	4	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EGFR CRISPLD2 TENM2 COL18A1	2.96e-06	197	23	4	ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 GRM7 TENM2 FBN1	2.96e-06	197	23	4	6806ec223e542f0475303698eb78c1cc527f5c6b
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR ITGB4 TENM2 EPHA2	3.02e-06	198	23	4	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TENM2 FBN1 FBN2 PEAR1	3.02e-06	198	23	4	7a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR CRISPLD2 TWSG1 FBN1	3.02e-06	198	23	4	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRISPLD2 TENM2 FBN1 PEAR1	3.08e-06	199	23	4	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	proximal-Epithelial-Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EGFR ITGB4 TENM2 EPHA2	3.14e-06	200	23	4	c6a491d3e2dae6618f25dc3c9aac08f657348168
ToppCell	proximal-Epithelial-Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EGFR ITGB4 TENM2 EPHA2	3.14e-06	200	23	4	f5d48f521abbd1e07de05f2b3768ad2f9675f1e1
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PHF14 TWSG1 FBN1 FBN2	3.14e-06	200	23	4	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	proximal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	EGFR ITGB4 TENM2 EPHA2	3.14e-06	200	23	4	8083047c213488e40b975013e3c5c43f7c0c15b2
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EGFR ITGB4 EPHA2	7.01e-05	157	23	3	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRISPLD2 COL18A1 PEAR1	7.15e-05	158	23	3	08806240228c5b780f5aef92ce2c278ae4d797cc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRISPLD2 COL18A1 PEAR1	7.15e-05	158	23	3	496b6988f7b3439968351840ae22f56ffa1643f1
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CRISPLD2 COL18A1 PEAR1	7.15e-05	158	23	3	5b3d30f92b619f14a7b48502170000fa5783358a
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EGFR TWSG1 FBN1	7.28e-05	159	23	3	7ed659163f45e0c4df4782997c0786900c8186c8
ToppCell	Basal_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ITGB4 TENM2 COL18A1	7.98e-05	164	23	3	85487a303194f5244956ec1ca2d1758d38117f41
ToppCell	-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	CRISPLD2 TNFRSF18 FBN1	8.72e-05	169	23	3	8ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL18A1 FBN1 PEAR1	8.72e-05	169	23	3	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	8.72e-05	169	23	3	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	8.72e-05	169	23	3	319cba07263bf41fcbcbfecd117f91b729394241
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGB4 FBN1 PEAR1	8.88e-05	170	23	3	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGB4 FBN1 PEAR1	8.88e-05	170	23	3	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	8.88e-05	170	23	3	3174ea9cf93892a8b41de10fd4ff6f06bb41502d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	8.88e-05	170	23	3	5de2f7d16a05af74ebfb1ca42d0f9c3c3524692d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGB4 FBN1 PEAR1	8.88e-05	170	23	3	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 FBN1 PEAR1	9.03e-05	171	23	3	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 FBN1 PEAR1	9.03e-05	171	23	3	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM3 COL18A1 PHF14	9.19e-05	172	23	3	b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRM3 COL18A1 PHF14	9.19e-05	172	23	3	2f1673fcb2356684d60871debb0f159aec553a1c
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	9.19e-05	172	23	3	30916a902c151907745756d14327e24adc34afef
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	9.35e-05	173	23	3	8335b77f730ed43fc348a005566e73a103c6774b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	9.35e-05	173	23	3	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	9.51e-05	174	23	3	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 GRM7 OTOGL	9.51e-05	174	23	3	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGFR OTOGL TENM2	9.67e-05	175	23	3	9142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	9.67e-05	175	23	3	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB4 FBN1 GNB5	9.84e-05	176	23	3	3766e0533b103ec92ac75eba3df02e287efc53fa
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGB4 FBN1 GNB5	9.84e-05	176	23	3	aa1bada2175d8370fc71939a607407155259d195
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRISPLD2 COL18A1 PEAR1	1.00e-04	177	23	3	452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EGFR CRISPLD2 FBN2	1.03e-04	179	23	3	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	droplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.03e-04	179	23	3	d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	EGFR CRISPLD2 FBN1	1.03e-04	179	23	3	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.05e-04	180	23	3	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EGFR CRISPLD2 FBN1	1.05e-04	180	23	3	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.05e-04	180	23	3	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.05e-04	180	23	3	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM3 CRISPLD2 GRM7	1.05e-04	180	23	3	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ITGB4 COL18A1 FBN2	1.05e-04	180	23	3	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	Mesenchymal_cells-Stromal_fibro.\|Mesenchymal_cells / Lineage and Cell class	CRISPLD2 TENM2 COL18A1	1.07e-04	181	23	3	f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CRISPLD2 OTOGL PEAR1	1.07e-04	181	23	3	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.07e-04	181	23	3	e2481291c236105774c53883e6f20da11941df9b
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CRISPLD2 TWSG1 FBN1	1.07e-04	181	23	3	091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCell	COPD-Epithelial-Basal\|World / Disease state, Lineage and Cell class	EGFR ITGB4 EPHA2	1.07e-04	181	23	3	6d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 GRM7 FBN2	1.07e-04	181	23	3	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 FBN1 PEAR1	1.07e-04	181	23	3	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 FBN1 PEAR1	1.07e-04	181	23	3	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRISPLD2 GRM7 FBN2	1.07e-04	181	23	3	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGFR GRN EPHA2	1.07e-04	181	23	3	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	Control-Epithelial-Basal\|World / Disease state, Lineage and Cell class	EGFR ITGB4 EPHA2	1.09e-04	182	23	3	759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 TWSG1 FBN1	1.09e-04	182	23	3	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNFRSF18 FBN1 PEAR1	1.09e-04	182	23	3	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNFRSF18 FBN1 PEAR1	1.09e-04	182	23	3	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	P28-Mesenchymal\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CRISPLD2 TWSG1 FBN1	1.09e-04	182	23	3	69f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	EGFR ITGB4 EPHA2	1.09e-04	182	23	3	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TNFRSF18 FBN1 PEAR1	1.09e-04	182	23	3	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRISPLD2 COL18A1 FBN1	1.09e-04	182	23	3	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRISPLD2 TWSG1 FBN1	1.09e-04	182	23	3	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CRISPLD2 TWSG1 FBN1	1.09e-04	182	23	3	19c5e3a9d9b3728303b682102e276adfe93aa759
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRM3 COL18A1 PEAR1	1.09e-04	182	23	3	fc4a5bf784705efe7965ce43ac23c2a8e602e90a
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	EGFR ITGB4 EPHA2	1.10e-04	183	23	3	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
Computational	Intermediate filaments.	ITGB4 TENM2 FBN2	1.71e-04	75	16	3	MODULE_154
Computational	Genes in the cancer module 297.	ITGB4 TENM2 FBN2	2.07e-04	80	16	3	MODULE_297
Computational	Intermediate filaments and keratins.	ITGB4 TENM2 FBN2	2.07e-04	80	16	3	MODULE_357
Computational	ECM and collagens.	CRISPLD2 TENM2 COL18A1 FBN1	2.79e-04	225	16	4	MODULE_47
Computational	Genes in the cancer module 321.	COL18A1 EPHA2 TWSG1	5.59e-04	112	16	3	MODULE_321
Computational	Neighborhood of EGFR	EGFR FBN2	1.00e-03	32	16	2	GNF2_EGFR
Computational	Neighborhood of MMP1	TWSG1 FBN1	1.00e-03	32	16	2	GNF2_MMP1
Computational	Adhesion molecules.	COL18A1 FBN1 FBN2	1.09e-03	141	16	3	MODULE_122
Computational	Neighborhood of TIMP2	EGFR FBN2	2.07e-03	46	16	2	GNF2_TIMP2
Computational	Neighborhood of KISS1	EGFR FBN2	2.35e-03	49	16	2	GNF2_KISS1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	ITGB4 COL18A1	2.44e-03	50	16	2	GAVISH_3CA_METAPROGRAM_EPITHELIAL_EMT_LIKE_1
Computational	Genes in the cancer module 287.	COL18A1 FBN1	2.44e-03	50	16	2	MODULE_287
Computational	Genes in the cancer module 175.	COL18A1 EPHA2	2.84e-03	54	16	2	MODULE_175
Computational	Placenta genes.	EGFR ITGB4 GRN FBN2	4.09e-03	463	16	4	MODULE_38
Computational	Heart, liver, kidney and pancreas metabolic and xenobiotic response genes.	EGFR COL18A1 GRN EPHA2 FBN2	5.92e-03	835	16	5	MODULE_88
Drug	Su-M	EGFR ITGB4 TNFRSF18 GRN	2.07e-07	52	23	4	CID000446388
Drug	Phthalylsulfathiazole [85-73-4]; Down 200; 10uM; PC3; HT_HG-U133A	EGFR ITGB4 OXLD1 FBN2 GNB5	1.30e-06	195	23	5	4653_DN
Drug	cis-MCG-I	GRM3 GRM7	2.72e-05	8	23	2	CID003035584
Drug	Propolis	GRN FBN1 FBN2	2.97e-05	60	23	3	ctd:D011429
Drug	1,3-cyclopentanedicarboxylic acid	GRM3 GRM7	3.50e-05	9	23	2	CID000107216
Drug	mM PEP	GRM3 GRM7	3.50e-05	9	23	2	CID005311462
Drug	AC1N21PP	GRM3 GRM7	3.50e-05	9	23	2	CID004014619
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A	EGFR ITGB4 PHF14 FBN1	3.91e-05	193	23	4	6400_DN
Drug	homocysteic acid	GRM3 GRM7 GRN	3.95e-05	66	23	3	CID000092117
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; HL60; HT_HG-U133A	CRISPLD2 GRM7 TWSG1 FBN2	4.07e-05	195	23	4	2707_DN
Drug	NS-105	GRM3 GRM7	4.37e-05	10	23	2	CID000198695
Drug	Nadolol [42200-33-9]; Up 200; 13uM; HL60; HT_HG-U133A	EGFR ITGB4 KMT2D FBN1	4.49e-05	200	23	4	3020_UP
Drug	cyclobutylene AP5	GRM3 GRM7	5.34e-05	11	23	2	CID000126582
Drug	AC1L1DME	GRM3 GRM7 TNFRSF18	5.80e-05	75	23	3	CID000002414
Drug	tetrathiomolybdate	EGFR ITGB4 FBN1	6.52e-05	78	23	3	ctd:C020809
Drug	AC1NSKBB	GRM3 GRM7	7.56e-05	13	23	2	CID005311256
Drug	Mspg	GRM3 GRM7	7.56e-05	13	23	2	CID003964410
Drug	MSOPPE	GRM3 GRM7	7.56e-05	13	23	2	CID005311463
Drug	2-methyl-6-styrylpyridine	GRM3 GRM7	8.82e-05	14	23	2	CID000235382
Drug	MTPG	GRM3 GRM7	8.82e-05	14	23	2	CID005311456
Drug	Rgd Peptide	ITGB4 GRN FBN1 FBN2	8.96e-05	239	23	4	CID000104802
Drug	Vitallium	ITGB4 COL18A1 EPHA2 FBN1	9.71e-05	244	23	4	ctd:D014800
Drug	germanium monoxide	GRM3 EGFR FBN2	1.07e-04	92	23	3	CID006327639
Drug	ethylglutamate	GRM3 GRM7	1.16e-04	16	23	2	CID000014241
Drug	2-PMPA	GRM3 GRM7	1.16e-04	16	23	2	CID010130754
Drug	pyrachlostrobin	EGFR CRISPLD2 COL18A1 GRN EPHA2 FBN1	1.20e-04	811	23	6	ctd:C513428
Drug	3HPG	GRM3 GRM7	1.32e-04	17	23	2	CID000001217
Drug	acromelic acid A	GRM3 GRM7	1.48e-04	18	23	2	CID000108086
Drug	Chlorogenic Acid	GRN FBN1 FBN2	1.49e-04	103	23	3	ctd:D002726
Drug	aminocyclopentane	GRM3 GRM7	1.65e-04	19	23	2	CID000002906
Drug	AC1L1C2F	EGFR ITGB4 COL18A1	1.81e-04	110	23	3	CID000001711
Drug	4-carboxy-3-hydroxyphenylglycine	GRM3 GRM7	1.83e-04	20	23	2	CID000001297
Drug	TAAD	FBN1 FBN2	2.03e-04	21	23	2	CID000133445
Drug	3,4-dihydroxyphenylglycine	GRM3 GRM7	2.03e-04	21	23	2	CID000027915
Drug	MSOP	GRM3 GRM7	2.44e-04	23	23	2	CID003964633
Drug	RS)-2-chloro-5-hydroxyphenylglycine	GRM3 GRM7	2.66e-04	24	23	2	CID003645780
Drug	2,3-pentanedione	EGFR COL18A1 FBN1	2.90e-04	129	23	3	ctd:C013186
Drug	AC1NQH9B	GRM3 GRM7	3.13e-04	26	23	2	CID005221504
Drug	BIBX1382BS	EGFR ITGB4	3.13e-04	26	23	2	CID006918508
Drug	benzylidenemalononitrile	EGFR GRN	3.37e-04	27	23	2	CID000017608
Drug	PBDA	GRM3 GRM7	4.17e-04	30	23	2	CID000004408
Drug	rosavin	FBN1 FBN2	4.75e-04	32	23	2	ctd:C529148
Drug	alpha-methyl-4-carboxyphenylglycine	GRM3 GRM7	4.75e-04	32	23	2	CID000001222
Drug	1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one	EGFR GRN EPHA2 FBN1	4.90e-04	373	23	4	ctd:C540355
Drug	isodesmosine	FBN1 FBN2	5.06e-04	33	23	2	CID000013811
Drug	NSC49080	FBN1 FBN2	5.06e-04	33	23	2	CID000002192
Drug	1-aminoindan-1,5-dicarboxylic acid	GRM3 GRM7	5.06e-04	33	23	2	CID000002071
Drug	pomiferin	GRN FBN1	5.06e-04	33	23	2	ctd:C474837
Drug	losartan	ITGB4 COL18A1 FBN1 FBN2	5.16e-04	378	23	4	CID000003961
Drug	CPPG	GRM3 GRM7	5.37e-04	34	23	2	CID000002878
Drug	1m5d	GRM3 GRM7	5.69e-04	35	23	2	CID000447082
Drug	Sistan	GRM3 GRM7	6.02e-04	36	23	2	CID003001858
Drug	benzyloxyaspartate	GRM3 GRM7	6.36e-04	37	23	2	CID004133412
Drug	L-BMAA	GRM3 GRM7	6.71e-04	38	23	2	CID000028558
Drug	4CPG	GRM3 GRM7	6.71e-04	38	23	2	CID000005115
Drug	4-aminopyrrolidine-2,4-dicarboxylate	GRM3 GRM7	7.07e-04	39	23	2	CID003331970
Drug	DETC-MeSO	GRM3 GRM7	7.07e-04	39	23	2	CID003035711
Drug	Aspartylglutamate	GRM3 EGFR	7.44e-04	40	23	2	CID000151403
Drug	L000369	GRM3 GRM7	7.81e-04	41	23	2	CID003931705
Drug	AC1NNRU4	GRM3 GRM7	7.81e-04	41	23	2	CID005126051
Drug	butenafine	GRM3 GRM7	8.20e-04	42	23	2	CID000002484
Drug	LY341495	GRM3 GRM7	8.60e-04	43	23	2	CID006324636
Drug	Joro spider toxin	GRM3 GRM7	8.60e-04	43	23	2	CID000119582
Drug	17-isoprogesterone	GRM3 EGFR CRISPLD2 GRM7 ITGB4 GRN	8.62e-04	1170	23	6	CID000004920
Drug	nickel subsulfide	EGFR ITGB4 EPHA2	8.69e-04	188	23	3	ctd:C017557
Drug	Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; PC3; HT_HG-U133A	EGFR GRM7 ITGB4	8.96e-04	190	23	3	5786_UP
Drug	PbCl2	GRM7 COL18A1	9.00e-04	44	23	2	CID000024459
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A	CRISPLD2 ITGB4 EPHA2	9.09e-04	191	23	3	7417_UP
Drug	0175029-0000 [211245-78-2]; Up 200; 10uM; PC3; HT_HG-U133A	TWSG1 FBN1 GNB5	9.23e-04	192	23	3	6875_UP
Drug	Meropenem [96036-03-2]; Up 200; 10.4uM; PC3; HT_HG-U133A	ITGB4 PHF14 FBN2	9.51e-04	194	23	3	5824_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	SHARPIN GRN EPHA2	9.51e-04	194	23	3	6927_UP
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; PC3; HT_HG-U133A	EGFR ITGB4 PHF14	9.51e-04	194	23	3	3795_DN
Drug	Etofylline [519-37-9]; Up 200; 17.8uM; HL60; HG-U133A	SHARPIN OXLD1 GNB5	9.66e-04	195	23	3	1409_UP
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; MCF7; HT_HG-U133A	SHARPIN CCDC15 ITGB4	9.66e-04	195	23	3	7413_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A	CRISPLD2 COL18A1 EPHA2	9.66e-04	195	23	3	7435_UP
Drug	Fusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; HL60; HT_HG-U133A	SHARPIN OXLD1 FBN2	9.66e-04	195	23	3	1293_DN
Drug	Gliclazide [21187-98-4]; Down 200; 12.4uM; PC3; HT_HG-U133A	ITGB4 FBN1 FBN2	9.66e-04	195	23	3	5089_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; PC3; HT_HG-U133A	GRM7 ITGB4 FBN1	9.80e-04	196	23	3	3742_DN
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; HL60; HT_HG-U133A	CRISPLD2 ITGB4 TWSG1	9.80e-04	196	23	3	3136_DN
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	CRISPLD2 COL18A1 GNB5	9.80e-04	196	23	3	7552_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	EGFR CRISPLD2 ITGB4	9.80e-04	196	23	3	7495_DN
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	GRM3 ITGB4 FBN1	9.80e-04	196	23	3	3545_UP
Drug	Diprophylline [479-18-5]; Up 200; 15.8uM; PC3; HT_HG-U133A	GRM7 ITGB4 FBN2	9.80e-04	196	23	3	5063_UP
Drug	Pempidine tartrate [546-48-5]; Up 200; 13uM; MCF7; HT_HG-U133A	EGFR GRM7 FBN1	9.80e-04	196	23	3	6027_UP
Drug	cysteine sulfinic acid	GRM3 GRM7	9.83e-04	46	23	2	CID000000109
Drug	Canavanine sulfate monohydrate (L,+) [206996-57-8]; Down 200; 13.6uM; HL60; HT_HG-U133A	CRISPLD2 ITGB4 FBN2	9.94e-04	197	23	3	2141_DN
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	SHARPIN EGFR TWSG1	9.94e-04	197	23	3	5238_DN
Drug	Sotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A	EGFR GRM7 KMT2D	9.94e-04	197	23	3	4160_UP
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; HL60; HT_HG-U133A	SHARPIN ITGB4 TWSG1	9.94e-04	197	23	3	2150_DN
Drug	Hecogenin [467-55-0]; Down 200; 9.2uM; HL60; HT_HG-U133A	GRM7 ITGB4 TWSG1	9.94e-04	197	23	3	2716_DN
Drug	Phensuximide [86-34-0]; Down 200; 21.2uM; PC3; HT_HG-U133A	EGFR ITGB4 OXLD1	9.94e-04	197	23	3	5097_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; PC3; HT_HG-U133A	EGFR CRISPLD2 ITGB4	9.94e-04	197	23	3	6310_UP
Drug	CGX 0596987; Down 200; 20uM; PC3; HT_HG-U133A	EGFR GRM7 GNB5	9.94e-04	197	23	3	6369_DN
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	EGFR ITGB4 OXLD1	9.94e-04	197	23	3	2126_DN
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CCDC15 COL18A1 GNB5	1.01e-03	198	23	3	2651_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	EGFR COL18A1 OXLD1	1.01e-03	198	23	3	7363_DN
Drug	Kawain [500-64-1]; Down 200; 17.4uM; HL60; HT_HG-U133A	CCDC15 ITGB4 GNB5	1.01e-03	198	23	3	2337_DN
Drug	Coralyne chloride hydrate [38989-38-7]; Down 200; 9.6uM; HL60; HT_HG-U133A	CCDC15 FBN2 GNB5	1.01e-03	198	23	3	1298_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; HL60; HT_HG-U133A	SHARPIN CCDC15 FBN2	1.01e-03	198	23	3	2352_DN
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	1.59e-06	3	22	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	3.18e-06	4	22	2	DOID:0060249 (is_implicated_in)
Disease	Familial thoracic aortic aneurysm and aortic dissection	COL18A1 FBN1 FBN2	8.23e-06	53	22	3	C4707243
Disease	Dermatitis	SHARPIN EGFR	6.33e-05	16	22	2	C0011603
Disease	breast carcinoma	GRM3 EGFR GRM7 FBN1 FBN2 GNB5	7.75e-05	1019	22	6	EFO_0000305
Disease	Astigmatism	EGFR GRM7 TENM2	1.18e-04	129	22	3	HP_0000483
Disease	cortical thickness	SHARPIN EGFR TENM2 COL18A1 FBN1 FBN2	1.26e-04	1113	22	6	EFO_0004840
Disease	Squamous cell carcinoma of lung	EGFR EPHA2	2.60e-04	32	22	2	C0149782
Disease	mortality	CRISPLD2 COL18A1 PHF14	2.81e-04	173	22	3	EFO_0004352
Disease	Alzheimer disease	SHARPIN EGFR TENM2 GRN	4.17e-04	485	22	4	MONDO_0004975
Disease	Congenital small ears	TWSG1 KMT2D	4.28e-04	41	22	2	C0152423
Disease	myopathy (implicated_via_orthology)	COL18A1 PEAR1	5.86e-04	48	22	2	DOID:423 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	OTOGL ITGB4	6.11e-04	49	22	2	EFO_0006954, EFO_1001069
Disease	Alcoholic Intoxication, Chronic	GRM3 EGFR GRM7	1.00e-03	268	22	3	C0001973
Disease	oral squamous cell carcinoma (is_marker_for)	EGFR KMT2D	1.01e-03	63	22	2	DOID:0050866 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LWDECCDCVGMCNPR	TWSG1	66	Q9GZX9
PMASSTCSCCWCCLG	FAM219B	176	Q5XKK7
MQPGDVCCWICIPCE	GRM3	521	Q14832
SWGCCPMPQASCCED	GRN	146	P28799
PCTWVMACAYAPSGC	GNB5	146	O14775
CSSECAPGMWGPQCD	PEAR1	131	Q5VY43
PPCCQFCEALQDACW	COL18A1	406	P39060
CNPWCPERCSGPMCT	CRISPLD2	146	Q9H0B8
QCVCEPGWTGPSCDC	ITGB4	561	P16144
PWFCDACKCGVSPSC	PHF14	371	O94880
PPTNCCMSGCPNCVW	OXLD1	86	Q5BKU9
SCQKCDPSCPNGSCW	EGFR	186	P00533
MQCCCDAGRCWSPGV	FBN1	356	P35555
CEQCWPESGECGPCE	EPHA2	366	P29317
QKGTPCCWTCEPCDG	GRM7	536	Q14831
CCCSKMPGEGWGDPC	FBN2	2126	P35556
MPLSDWCCGICEEAP	nan	1	Q1T7F1
WVCCCNSMVCNAGGP	GML	101	Q99445
CCPEWECPCRCSMLS	OTOGL	1526	Q3ZCN5
SGQCCPTWHCECNCE	OTOGL	2066	Q3ZCN5
PGCEMCSTQRPCTWD	SHARPIN	366	Q9H0F6
GLCSCDPNWMGPDCS	TENM2	721	Q9NT68
CCCGPDFWDAHPDTC	CCDC15	886	Q0P6D6
YPGEECCSEWDCMCV	TNFRSF18	61	Q9Y5U5
CKWCVSCMQCGAASP	KMT2D	1471	O14686