Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessneuron development

ROCK2 JAK2 PBRM1 CLIC5 ROR1 RAPGEF4 DLG2 TRPM1 ULK1 POTEJ CTNND2 THOC2 NEUROD6 ADAM10 WASF1 MAP4K4 ANKRD27 EPHA3 RIT2

1.04e-0514638819GO:0048666
GeneOntologyBiologicalProcessneuron projection development

ROCK2 JAK2 PBRM1 CLIC5 ROR1 RAPGEF4 ULK1 POTEJ CTNND2 THOC2 NEUROD6 ADAM10 WASF1 MAP4K4 ANKRD27 EPHA3 RIT2

2.61e-0512858817GO:0031175
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

NETO2 RAPGEF4 DLG2 ADAM10

5.66e-0549884GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

NETO2 RAPGEF4 DLG2 ADAM10

5.66e-0549884GO:0099633
GeneOntologyBiologicalProcesscell junction organization

ROCK2 ACE2 KY PKP4 DLGAP4 RAPGEF4 DLG2 POTEJ CTNND2 ADAM10 WASF1 MAP4K4 EPHA3 TJP3

6.15e-059748814GO:0034330
GeneOntologyBiologicalProcessregulation of postsynaptic membrane neurotransmitter receptor levels

NETO2 RAPGEF4 DLG2 CTNND1 CTNND2 ADAM10

7.29e-05164886GO:0099072
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

RIT1 ROCK2 DENND4B RAPGEF4 ULK1 ARHGAP8 ARHGEF17 WASF1 MAP4K4 RIT2

9.77e-055388810GO:0007264
GeneOntologyBiologicalProcessregulation of neurotransmitter receptor localization to postsynaptic specialization membrane

NETO2 RAPGEF4 ADAM10

1.61e-0425883GO:0098696
GeneOntologyCellularComponentpostsynaptic specialization

ROCK2 NETO2 PKP4 DLGAP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 ADAM10

4.10e-055038610GO:0099572
GeneOntologyCellularComponentanchoring junction

JAK2 PKP4 ABCB11 NOX4 DLG2 PARVB CTNND1 CTNND2 MMP13 ADAM10 WASF1 MAP4K4 FRMD4B TJP3

4.19e-059768614GO:0070161
GeneOntologyCellularComponentpostsynaptic density

ROCK2 NETO2 PKP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 ADAM10

9.89e-05451869GO:0014069
GeneOntologyCellularComponentasymmetric synapse

ROCK2 NETO2 PKP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 ADAM10

1.51e-04477869GO:0032279
GeneOntologyCellularComponentadherens junction

PKP4 DLG2 CTNND1 CTNND2 ADAM10 FRMD4B

2.43e-04212866GO:0005912
GeneOntologyCellularComponentneuron to neuron synapse

ROCK2 NETO2 PKP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 ADAM10

2.99e-04523869GO:0098984
GeneOntologyCellularComponentintercellular canaliculus

ABCB11 MMP13

5.91e-049862GO:0046581
GeneOntologyCellularComponentcell-cell junction

PKP4 ABCB11 DLG2 CTNND1 CTNND2 MMP13 ADAM10 FRMD4B TJP3

7.21e-04591869GO:0005911
GeneOntologyCellularComponentpostsynapse

ROCK2 JAK2 NETO2 PKP4 DLGAP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 ADAM10 WASF1

9.16e-0410188612GO:0098794
MousePhenoabnormal spatial working memory

NSUN5 ATXN1 DLGAP4 ALDH2 SARDH THOC2

1.01e-0594746MP:0008428
DomainPlakophilin/d_Catenin

PKP4 CTNND1 CTNND2

3.37e-067873IPR028435
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ROCK2 DLGAP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 WASF1

2.57e-0725188827507650
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

ROCK2 PKP4 DLG2 RICTOR CTNND1 MAP4K4 DEPDC1B EPHA3 EHD4

5.05e-0737788938117590
Pubmed

DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

PKP4 CTNND1 CTNND2

5.44e-07788325009281
Pubmed

The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.

PKP4 CTNND1 CTNND2

8.69e-07888311821434
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ROCK2 HDAC3 PBRM1 MDN1 PKP4 DLGAP4 RAPGEF4 DLG2 ADGRA1 CTNND1 CTNND2 WASF1 MAP4K4

9.15e-07963881328671696
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ROCK2 DENND4B PKP4 DLGAP4 RICTOR CTNND1 MAP4K4 DEPDC1B EPHA3

1.26e-0642188936976175
Pubmed

Identification of NPM-ALK interacting proteins by tandem mass spectrometry.

JAK2 SMC6 IRS1 MAP3K1

6.28e-064788414968112
Pubmed

ULK1-regulated autophagy: A mechanism in cellular protection for ALDH2 against hyperglycemia.

ULK1 ALDH2

6.33e-06288229128638
Pubmed

Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence.

ACE2 IRS1

6.33e-06288224134599
Pubmed

Endogenous formaldehyde is a memory-related molecule in mice and humans.

ALDH2 SARDH

6.33e-06288231815201
Pubmed

Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development.

CTNND1 CTNND2

6.33e-06288219403811
Pubmed

Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors.

RICTOR CTNND2

6.33e-06288234455763
Pubmed

RIC, a calmodulin-binding Ras-like GTPase.

RIT1 RIT2

6.33e-0628828918462
Pubmed

δ-Catenin Promotes Bevacizumab-Induced Glioma Invasion.

CTNND1 CTNND2

6.33e-06288230872378
Pubmed

NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.

JAK2 NOX4

6.33e-06288217983808
Pubmed

Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.

PKP4 CTNND1

6.33e-06288217264675
Pubmed

Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family.

PKP4 CTNND2

6.33e-0628829342840
Pubmed

Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.

CTNND1 CTNND2

6.33e-06288220108168
Pubmed

Intratumor δ-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression.

CTNND1 CTNND2

6.33e-06288232313227
Pubmed

Heterozygous deficiency of delta-catenin impairs pathological angiogenesis.

CTNND1 CTNND2

6.33e-06288220048286
Pubmed

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.

CTNND1 CTNND2

6.33e-06288218809907
Pubmed

A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.

CTNND1 CTNND2

6.33e-06288229875160
Pubmed

δ-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases.

CTNND1 CTNND2

6.33e-06288225635825
Pubmed

Developmental functions of the P120-catenin sub-family.

CTNND1 CTNND2

6.33e-06288216942809
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

BMP2K AVL9 TGFBRAP1 ULK1 ARHGAP8 ANKRD27 EHD4

8.30e-0628588734369648
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ROCK2 ACE2 PKP4 ROR1 RICTOR CTNND1 MAP4K4 DEPDC1B EPHA3

1.43e-0556988930639242
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

ROCK2 ORC5 NSUN5 MDN1 WDR33 PARVB TRMT1L CTNND1 EHD4

1.71e-0558288920467437
Pubmed

MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.

IRS1 MAP3K1

1.90e-05388212458213
Pubmed

Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.

RIT1 RIT2

1.90e-0538828824319
Pubmed

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.

ROCK2 MMP13

1.90e-05388217876296
Pubmed

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.

JAK2 IRS1

1.90e-05388211208867
Pubmed

Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer.

CTNND1 CTNND2

1.90e-05388216226102
Pubmed

Mef2 promotes spine elimination in absence of δ-catenin.

CTNND1 CTNND2

1.90e-05388223328440
Pubmed

Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression.

FOXN1 MMP13

1.90e-05388221539913
Pubmed

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.

HDAC3 ATXN1

1.90e-05388224594842
Pubmed

Isolation of human delta-catenin and its binding specificity with presenilin 1.

CTNND1 CTNND2

1.90e-05388210208590
Pubmed

Loss of δ-catenin function in severe autism.

CTNND1 CTNND2

1.90e-05388225807484
Pubmed

PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.

PKP4 CTNND2

1.90e-05388210896674
Pubmed

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.

NOX4 IRS1

1.90e-05388214966267
Pubmed

Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.

ACE2 KDM5B

1.90e-05388232726325
Pubmed

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells.

ROCK2 JAK2

1.90e-05388230413785
Pubmed

Identification of novel NPRAP/δ-catenin-interacting proteins and the direct association of NPRAP with dynamin 2.

CTNND1 CTNND2

1.90e-05388222022388
Pubmed

The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes.

RIT1 FOXN1

1.90e-05388239161959
Pubmed

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.

ADAM10 EPHA3

1.90e-05388224117969
Pubmed

The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.

JAK2 IRS1

1.90e-05388212960006
Pubmed

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.

HDAC3 ATXN1

1.90e-05388215016912
Pubmed

ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock.

HDAC3 ALDH2

1.90e-05388236992838
Pubmed

Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation.

RIT1 RIT2

1.90e-05388215831491
Pubmed

Upregulation of δ-catenin is associated with poor prognosis and enhances transcriptional activity through Kaiso in non-small-cell lung cancer.

CTNND1 CTNND2

1.90e-05388221070476
Pubmed

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

ADAM10 EPHA3

1.90e-05388216239146
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

MDN1 CLIC5 ATXN1 SGSH SURF2 COX6A1 LPGAT1 NOX4 RICTOR PARVB CTNND1 SMURF2 EHD4

2.20e-051293881315342556
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

ORC5 HDAC3 NSUN5 MDN1 NLRX1 ATG2B RICTOR CTNND1 ANKRD27

2.35e-0560688936538041
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

PKP4 DLGAP4 ROR1 ATG2B CTNND1 MAP4K4 DEPDC1B EPHA3

2.50e-0546788830194290
Pubmed

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.

PKP4 CTNND1 CTNND2

2.67e-052388325523391
Pubmed

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

JAK2 PBRM1 ROR1 MAP3K1

3.27e-057188428319113
Pubmed

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes.

HDAC3 MMP13

3.79e-05488227662443
Pubmed

Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing.

FOXN1 MMP13

3.79e-05488228068897
Pubmed

Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status.

JAK2 MMP13

3.79e-05488216877349
Pubmed

Involvement of Janus kinases in the insulin signaling pathway.

JAK2 IRS1

3.79e-0548828536716
Pubmed

The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PKP4 CTNND1

3.79e-05488217115030
Pubmed

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

CTNND1 CTNND2

3.79e-05488219706605
Pubmed

PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.

PKP4 CTNND2

3.79e-05488219706687
Pubmed

Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity.

CTNND1 CTNND2

3.79e-05488224562000
Pubmed

Regulation of the rapsyn promoter by kaiso and delta-catenin.

CTNND1 CTNND2

3.79e-05488215282317
Pubmed

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

JAK2 HSPB2

3.79e-05488229650953
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

AVL9 LPIN2 LPGAT1 WASF1

6.04e-05838849039502
Pubmed

Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.

NOX4 HSPB2

6.30e-05588224831009
Pubmed

Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells.

JAK2 NOX4

6.30e-05588219834108
Pubmed

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

RAPGEF4 RYR2

6.30e-05588223363625
Pubmed

A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.

RIT1 RIT2

6.30e-05588210869344
Pubmed

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.

PKP4 CTNND2

6.30e-05588210037471
Pubmed

Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.

JAK2 IRS1

6.30e-0558827544789
Pubmed

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin.

JAK2 IRS1

6.30e-05588215316008
Pubmed

Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.

PKP4 CTNND2

6.30e-0558829721216
Pubmed

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

JAK2 FOXN1

6.30e-05588215292206
Pubmed

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.

JAK2 IRS1

6.30e-0558829492017
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KDM5B MDN1 ATXN1 RICTOR IRS1 CTNND1 ARHGEF17 MAP4K4 DEPDC1B ANKRD27

6.49e-05861881036931259
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

JAK2 MDN1 NETO2 NLRX1 DLGAP4 ROR1 SMC6 PPA1 ALDH2 ACSF2 AKR7A2

7.58e-051061881133845483
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

PKP4 DLGAP4 RAPGEF4 DLG2 CTNND2 WASF1

8.21e-0528188628706196
Pubmed

Suppressor of cytokine signaling-3 Provides a novel interface in the cross-talk between angiotensin II and insulin signaling systems.

JAK2 IRS1

9.43e-05688215514089
Pubmed

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.

MAP4K4 MAP3K1

9.43e-0568829135144
Pubmed

Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.

CTNND1 CTNND2

9.43e-05688212835311
Pubmed

ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.

ROCK2 SMURF2

9.43e-05688228049720
Pubmed

A FXYD5/TGF‑β/SMAD positive feedback loop drives epithelial‑to‑mesenchymal transition and promotes tumor growth and metastasis in ovarian cancer.

FXYD5 SMURF2

9.43e-05688231746425
Pubmed

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.

JAK2 IRS1

9.43e-0568827782332
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ORC5 HDAC3 TDRKH NSUN5 PBRM1 MDN1 BMP2K PKP4 COX6A1 SUPT7L RICTOR TRMT1L CTNND2

9.81e-051497881331527615
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

JAK2 GTF2H2 BMP2K NLRX1 ULK1 CTNND1 MAP4K4 MAP3K1 ACOX3 AKR7A2

1.02e-04910881036736316
Pubmed

MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.

HDAC3 MMP13

1.32e-04788227638301
Pubmed

Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.

CTNND1 CTNND2

1.32e-04788220573893
Pubmed

HDAC3 Is a Master Regulator of mTEC Development.

FOXN1 HDAC3

1.75e-04888227068467
Pubmed

Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts.

CTNND1 CTNND2

1.75e-04888235874813
Pubmed

Transcriptional and subcellular regulation of the TRIP-Br family.

HDAC3 SUPT7L

1.75e-04888217141982
Pubmed

Biochemical characterization of the Ras-related GTPases Rit and Rin.

RIT1 RIT2

1.75e-04888210545207
Pubmed

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.

RICTOR IRS1

1.75e-04888225273559
Pubmed

Btbd11 supports cell-type-specific synaptic function.

ATXN1 DLG2

1.75e-04888237261953
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

PBRM1 MDN1 SUPT7L POTEJ CTNND2 WASF1 RYR2 AKR7A2

2.18e-0463888831182584
Pubmed

Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.

JAK2 IRS1

2.25e-04988210455176
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

PKP4 CTNND1 CTNND2 WASF1 MAP4K4

2.37e-0421888533378226
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

PCYT1A WDR33 PKP4 RICTOR TRMT1L MAP4K4 DEPDC1B MAP3K1

3.02e-0467088822990118
Pubmed

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

ATXN1 LPIN2 DLG2 CTNND2

3.82e-0413488424324551
InteractionRAC1 interactions

RIT1 ROCK2 HDAC3 PCYT1A MDN1 ATXN1 PKP4 DLGAP4 RICTOR PPA1 CTNND1 ARHGAP8 WASF1 MAP4K4 DEPDC1B SMURF2 EHD4

1.49e-0610638417int:RAC1
InteractionAFDN interactions

RIT1 ATXN1 PKP4 RICTOR CTNND1 MAP4K4 DEPDC1B FRMD4B RIT2

1.02e-05333849int:AFDN
InteractionDLGAP1 interactions

DLGAP4 RAPGEF4 DLG2 CTNND1 CTNND2 WASF1 MAP4K4

1.02e-05180847int:DLGAP1
InteractionIGF1R interactions

RIT1 JAK2 HDAC3 MDN1 RICTOR IRS1 ADAM10 WASF1 MAP4K4 AKR7A2

2.42e-054678410int:IGF1R
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PKP4 CTNND1 CTNND2

4.72e-0443643409
CoexpressionGSE3982_CTRL_VS_LPS_4H_MAC_UP

ORC5 AVL9 WDR33 ROR1 IRS1 CTNND1 THOC2 MAP3K1 AKR7A2

2.03e-08200869M5367
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

ROCK2 ORC5 KDM5B MDN1 BMP2K ATXN1 AVL9 PKP4 ROR1 IRS1 THOC2 ADAM10 WASF1 SMURF2

7.23e-078568614M4500
CoexpressionGSE25123_WT_VS_PPARG_KO_MACROPHAGE_IL4_AND_ROSIGLITAZONE_STIM_DN

KDM5B MDN1 DLGAP4 FBXO42 FXYD5 WASF1 MAP3K1

3.96e-06197867M7921
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

RIT1 JAK2 MDN1 BMP2K ATXN1 AVL9 DENND4B PKP4 LPGAT1 PARVB ACSF2 THOC2 ADAM10 WASF1 SMURF2

8.87e-0612158615M41122
CoexpressionGSE32986_UNSTIM_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_DN

MAN2B2 CLIC5 ATXN1 SGSH ATG2B MAP3K1

5.18e-05200866M8620
CoexpressionBLALOCK_ALZHEIMERS_DISEASE_DN

ROCK2 JAK2 ORC5 ATXN1 NETO2 COX6A1 SUPT7L RAPGEF4 DLG2 PPA1 ALDH2 NEUROD6 WASF1 RIT2

5.24e-0512488614M17728
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5

TDRKH CLIC5 ATXN1 NETO2 ADGRA1 CTNND2 SARDH EPHA3

4.20e-06232858Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ROCK2 PBRM1 CLIC5 TGFBRAP1 IRS1 TRMT1L MAP3K1

8.15e-0818687703db813598b67b1e08f759758a1c2023396921fa
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1 MAP4K4 EHD4

1.34e-072008773b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROCK2 PKP4 RAPGEF4 PARVB CTNND1 CTNND2

2.05e-06191876a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

JAK2 PKP4 PARVB PPA1 MAP4K4 SMURF2

2.68e-06200876a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1 SMURF2

2.68e-062008762d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

CLIC5 PKP4 RAPGEF4 PARVB CTNND1 CTNND2

2.68e-06200876b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B FXYD5 WASF1 GPR132 ACOX3

1.66e-05162875388670cf3acef17df971c0d8ae3ce14398945192
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B FXYD5 WASF1 GPR132 ACOX3

1.66e-051628759333d923225df7bfdf6b3a4c32816751315aec50
ToppCellfacs-Kidney-nan-18m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COX6A1 NOX4 ALDH2 SARDH AKR7A2

2.53e-051778757f58286fc8797e9bdcf8ece0849f55680905955d
ToppCellfacs-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LPGAT1 NOX4 ALDH2 SARDH AKR7A2

2.53e-05177875d4cd54c07f1e51b5485270348fb7195d53465027
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

TDRKH DLGAP4 RAPGEF4 ANKRD27 EPHA3

2.60e-05178875edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

ACE2 ROR1 NOX4 PWWP3B ACSF2

3.30e-05187875acd305475f3609800af0d7bc68d83ef41228080b
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIC5 RAPGEF4 PARVB CTNND1 CTNND2

3.56e-05190875474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.83e-0519387502f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.83e-051938756e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

KDM5B PBRM1 AVL9 TGFBRAP1 THOC2

3.83e-05193875abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.83e-05193875af5108260783e69a7d67896c5bf64f862525926d
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.83e-051938755122b1ffba42de190061be34ecdc6176f84e56a3
ToppCellfacs-Tongue-nan-3m-Epithelial-keratinocyte|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXN1 ACE2 KDM5B BMP2K DLG2

3.83e-0519387533437fdb417d78463caee14a9f0e094da1733829
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CLIC5 ROR1 DLG2 CTNND1 TMC5

3.93e-0519487553f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.93e-0519487543f92b0533e26633dc94cce554045d641ef8fd76
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.93e-051948750b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.93e-051948751d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.93e-0519487558f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKP4 RAPGEF4 PARVB CTNND1 CTNND2

3.93e-05194875bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CLIC5 ROR1 DLG2 CTNND1 TMC5

4.02e-051958759406866f99555198a9be311fbd65751b70f35446
ToppCell367C-Lymphocytic-CD4_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LPIN2 FXYD5 PPA1 GPR132 FRMD4B

4.02e-051958758b2e29f3b12fcc474abdf3707de96e4613ead1bc
ToppCellIPF-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ATXN1 LPIN2 GPR132 FRMD4B RYR2

4.12e-051968756e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCellCOPD-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ATXN1 LPIN2 GPR132 FRMD4B RYR2

4.12e-05196875c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ROR1 DLG2 FRMD4B RYR2 EPHA3

4.22e-05197875f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1

4.54e-0520087572ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1

4.54e-05200875dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1

4.54e-052008756f531a418ff25b59a543800cf4bce7b72404ce08
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ROCK2 PKP4 RAPGEF4 PARVB CTNND1

4.54e-052008755c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

DLG2 NEUROD6 WASF1 FRMD4B RYR2

4.54e-05200875db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

DLG2 NEUROD6 WASF1 FRMD4B RYR2

4.54e-0520087530a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PKP4 RAPGEF4 PARVB CTNND1 MAP4K4

4.54e-052008753585484c7e24e941708bee471ca607d8ccee74e6
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAK2 ACE2 ALDH2 CTNND1

2.54e-04157874e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

JAK2 ACE2 ALDH2 CTNND1

2.60e-04158874e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CTNND2 RYR2 EPHA3 RIT2

2.66e-041598745335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellE18.5-Immune-Immune_Myeloid-DC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B FXYD5 GPR132 ACOX3

2.73e-041608749f1fec2cf565193c73cc3c8a4f0476e57478e3b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR1 RAPGEF4 TMC5 ARHGEF17

2.79e-041618741b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L5_RORB_SNHG7|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B TMC5 NEUROD6

2.92e-041638746ed2a71385e85508ed513282c06440add7cc010c
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PKP4 RAPGEF4 PARVB EHD4

3.13e-04166874f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NOX4 TRPM1 CTNND2 TMC5

3.21e-041678743edb0570e583bb527165bcd8a4c25a042054043b
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXN1 ACE2 KDM5B DLG2

3.21e-0416787402c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L5_RORB_SNHG7|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B TMC5 NEUROD6

3.21e-041678745d89f5bcd0aaa772c1d09c2cc46fbfe0a90f9f12
ToppCelldroplet-Lung-LUNG-30m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK2 ROR1 CTNND2 TJP3

3.28e-041688740e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NSUN5 DEPDC1B ANKRD27 TJP3

3.28e-04168874de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

ROR1 PPA1 RYR2 EPHA3

3.35e-04169874a4204bdd75837f5fee9aaac459cb4c19ee2a7bf4
ToppCellmetastatic_Lymph_Node-T/NK_cells-Exhausted_Tfh|metastatic_Lymph_Node / Location, Cell class and cell subclass

KDM5B CLIC5 SARDH RYR2

3.35e-04169874ad9054ee09033b648a76baf1b2ec4a6ab1394bde
ToppCelldroplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K DLG2 CTNND2 TJP3

3.43e-04170874749144a1a869a6bf9acdd227184319083367dc3f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATXN1 LPIN2 FRMD4B ACOX3

3.43e-04170874adb625124832b0786a590e8f75b61e7263a1e0d4
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXN1 HDAC3 FBXO42 SHLD1

3.43e-04170874833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCelldroplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP2K DLG2 CTNND2 TJP3

3.43e-0417087425d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9|TCGA-Bladder / Sample_Type by Project: Shred V9

RIT1 ABCB11 IRS1 MMP13

3.51e-04171874adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.51e-041718749e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.51e-04171874f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.51e-041718746a489a75eeab2a2d48d604682e93599c20a945fe
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.59e-0417287492e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ROR1 DLG2 CTNND2 TJP3

3.59e-04172874b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B2 SGSH ACSF2 ADAM10

3.66e-0417387403b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCellnormal_Lung-T/NK_cells-Exhausted_Tfh|normal_Lung / Location, Cell class and cell subclass

ATXN1 SARDH ACOX3 RYR2

3.66e-04173874e8ead6c51c41dbd43c717ba9d1a7a0ab39c79330
ToppCellPND28-Endothelial-Endothelial_lymphatic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B2 SGSH ACSF2 ADAM10

3.66e-041738742978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 ROR1 TMC5 HSPB2

3.66e-041738742415b6ff49f334da570577d4e93484d024a3dbd5
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.66e-041738745aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

BMP2K SMC6 LPGAT1 MAP3K1

3.66e-04173874d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CLIC5 RAPGEF4 PARVB EHD4

3.66e-04173874ad9777e4ae70b11676ec735eb6db91776ca0cb19
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B2 SGSH ACSF2 ADAM10

3.66e-0417387412da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 ROR1 TMC5 HSPB2

3.66e-041738742acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ROR1 DLG2 CTNND2 TJP3

3.66e-041738746c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B2 SGSH ACSF2 ADAM10

3.66e-0417387423d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY PKP4 LPGAT1 IRS1

3.75e-04174874f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 SGSH PKP4 ROR1

3.75e-04174874c58328c2f262506a4518f49f148e29874faf9171
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.75e-041748742947e5906b172d149412fa4e77476fce4ea695d2
ToppCellTCGA-Thymus-Primary_Tumor|TCGA-Thymus / Sample_Type by Project: Shred V9

FOXN1 AKR7A2

3.82e-0415872f8b2178996c48a2b0c84941accc5a9d5f6944e35
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma|TCGA-Thymus / Sample_Type by Project: Shred V9

FOXN1 AKR7A2

3.82e-0415872ae7c5e1c73b66b261e5ed9e7357501ad5c240068
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NOX4 PWWP3B NEUROD6 EPHA3

3.83e-0417587406af6629766e2054e6995e8cdb3907658fec49d3
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLIC5 DLG2 CTNND2 ARHGAP8

3.83e-04175874442f261a3b2c4d2523f7d4089178f8c79cac2f0f
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLIC5 DLG2 CTNND2 ARHGAP8

3.83e-0417587435fb7735dd3355476fe60404833cb60bd066bcf1
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOX4 DLG2 ARHGEF17 EPHA3

4.00e-04177874bd602db857f37869ef76d14c05ef522c509f08ee
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

CLIC5 ROR1 CTNND2 TMC5

4.17e-04179874a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CLIC5 ROR1 CTNND2 TMC5

4.17e-041798744f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PKP4 MMP13 ARHGAP8 FRMD4B

4.17e-0417987413d80ae2e43a5daad0aeb5f47338efca2c58800a
ToppCellmild_COVID-19_(asymptomatic)-cDC|World / disease group, cell group and cell class (v2)

PPA1 ALDH2 CTNND1 ACSF2

4.26e-0418087468d1c867734fb2977b01ac686b20bf602f9a6b72
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOX4 ALDH2 SARDH AKR7A2

4.35e-04181874bec7076efe94898213a62db72d171d737949977e
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOX4 ALDH2 SARDH AKR7A2

4.35e-04181874cf149b30b814cf87c9e923ef502cadf7fe4a3597
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype|TCGA-Lung / Sample_Type by Project: Shred V9

TDRKH LPIN2 TMC5 TJP3

4.35e-04181874c783c2ecca7ab8e07646fa92dc7d436d24939d03
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

DLG2 ACSF2 FRMD4B RYR2

4.35e-04181874c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellCD8+_Memory_T_cell-RSV-2|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NETO2 PARVB PPA1 ALDH2

4.44e-04182874f5f17a80552f0ad05ed1a2529a04ee55deb1e130
ToppCelldroplet-Kidney-nan-21m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKP4 NOX4 SARDH AKR7A2

4.44e-04182874942c18a27b22fb33a5200d5717cad972f3ef0576
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

CLIC5 FXYD5 PARVB RYR2

4.44e-04182874fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

BMP2K SMC6 LPIN2 EHD4

4.53e-04183874dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

CLIC5 ROR1 CTNND2 TMC5

4.53e-04183874942530449e9c6583705eeb8f6f12621daea57252
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|390C / Donor, Lineage, Cell class and subclass (all cells)

PARVB TRMT1L ANKRD27 FRMD4B

4.53e-04183874228092290dbb08785c4eda224e3ad03e99e10fab
ToppCelldroplet-Kidney-nan-21m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COX6A1 NOX4 ALDH2 AKR7A2

4.53e-0418387401e7256c9e0ce53f8e10f3d3a5be15dedd312426
ToppCellwk_15-18-Hematologic-Myeloid-MEP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FXYD5 ABCB11 PARVB ANKRD27

4.62e-0418487419d61d0ab038b7e729e13a46f88b8cf31759485d
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CLIC5 ROR1 CTNND1 CTNND2

4.62e-0418487457c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

ACE2 ROR1 NOX4 ACSF2

4.62e-04184874dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

ROR1 DLG2 CTNND2 RYR2

4.62e-04184874ab7a1620c14a9d9b6be1b47c559931e345e9eef8
DiseaseCarcinoma of lung

RIT1 RICTOR EPHA3

3.78e-0523843C0684249
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5B PKP4 DLGAP4 CTNND1 CTNND2

7.55e-05152845DOID:0060041 (implicated_via_orthology)
Diseasecolorectal cancer (is_marker_for)

HDAC3 PBRM1 RICTOR ADAM10 MAP4K4

8.80e-05157845DOID:9256 (is_marker_for)
Diseaseneuroimaging measurement, brain volume measurement

PBRM1 DLG2 NEUROD6 MAP3K1 EPHA3 RIT2

1.70e-04286846EFO_0004346, EFO_0006930
Diseaseserum gamma-glutamyl transferase measurement

PBRM1 FBXO42 COX6A1 ABCB11 PARVB ULK1 ALDH2 FUT3 RYR2 TJP3

2.69e-049148410EFO_0004532
Diseasethrombosis (implicated_via_orthology)

JAK2 ACE2

3.55e-0410842DOID:0060903 (implicated_via_orthology)
DiseaseMyeloproliferative disease

JAK2 ATG2B

5.19e-0412842C0027022
Diseaselung non-small cell carcinoma (is_implicated_in)

JAK2 HDAC3 PBRM1 MAP3K1

6.80e-04139844DOID:3908 (is_implicated_in)
Diseasereticulocyte measurement

RIT1 BMP2K ATXN1 LPIN2 FXYD5 RICTOR IRS1 CTNND1 MAP3K1 EHD4

8.11e-0410538410EFO_0010700
Diseasefish consumption measurement

ATXN1 DLG2 ALDH2

8.18e-0464843EFO_0010139
Diseasemyocardial infarction (implicated_via_orthology)

JAK2 ACE2 MMP13

8.95e-0466843DOID:5844 (implicated_via_orthology)
Diseaseneuroimaging measurement

ORC5 DENND4B ROR1 COX6A1 DLG2 TMC5 FRMD4B MAP3K1 EPHA3 RIT2

9.10e-0410698410EFO_0004346
Diseaseheart disease (biomarker_via_orthology)

JAK2 ALDH2

1.06e-0317842DOID:114 (biomarker_via_orthology)
Diseaseesophageal carcinoma, gastric carcinoma

ATG2B TRPM1

1.06e-0317842EFO_0000178, EFO_0002916
Diseaseesophagus squamous cell carcinoma (is_marker_for)

JAK2 KDM5B RICTOR

1.25e-0374843DOID:3748 (is_marker_for)
Diseasealcohol drinking

ROR1 ALDH2 CTNND2

1.62e-0381843EFO_0004329
Diseasehepatocellular carcinoma (is_marker_for)

JAK2 RICTOR ALDH2 SARDH MAP3K1

1.71e-03301845DOID:684 (is_marker_for)
Diseaseparental emotion expression measurmement, conduct disorder

RIT1 RIT2

2.30e-0325842EFO_0004216, EFO_0008342
Diseasealcohol use disorder (implicated_via_orthology)

KDM5B PBRM1 CLIC5 RYR2

2.36e-03195844DOID:1574 (implicated_via_orthology)
DiseaseLewy body dementia, Lewy body dementia measurement

PARVB CTNND2

2.49e-0326842EFO_0006792, EFO_0006799

Protein segments in the cluster

PeptideGeneStartEntry
PHSYEDPYFDDRVHF

PKP4

1136

Q99569
DPYFDDRVHFPASTD

PKP4

1141

Q99569
DLFYLHAPDHGTPVE

AKR7A2

136

O43488
YDPATEEFIIHSPDF

ACOX3

176

O15254
TLDPDTAHPHLFLYE

BTN1A1

306

Q13410
DRTLPFHSVIYHEDD

ADAM10

146

O14672
FSRHPAEEPEYAYHI

ADGRA1

426

Q86SQ6
EFHNVTFHYPSRPEV

ABCB11

421

O95342
DFEDNRHLYRFPPSS

DEPDC1B

96

Q8WUY9
YPAELEDFFHTHPKV

ACSF2

521

Q96CM8
YESRHVVVHPSPSDY

ATXN1

356

P54253
PSGFHEDDPFFYDEH

FXYD5

126

Q96DB9
DPEHRPDIFQVSYFA

BMP2K

301

Q9NSY1
PHYDDVHEYLRPEND

CLIC5

31

Q9NZA1
FFEDQVHHRPPASEY

CTNND2

1171

Q9UQB3
FPRIHYNSHFEVPEE

DLGAP4

71

Q9Y2H0
ECLFPTDFHSVPPHY

ATG2B

611

Q96BY7
YPPNHVFHIDESTRH

JAK2

96

O60674
FLAVSPSDPRYHEVH

NSUN5

286

Q96P11
TRPEGTDSYIFEFPH

ARHGEF17

1441

Q96PE2
TDSYIFEFPHPDARL

ARHGEF17

1446

Q96PE2
PDEPFTRQFYFVHSA

ANKRD27

931

Q96NW4
HQPERFFDEIHTYSP

FBXO42

201

Q6P3S6
FHAPEPKAHYEPADR

MAP4K4

551

O95819
FYGPIFIHPEETEHE

PBRM1

1191

Q86U86
SFEFHQDPESYHTLP

MDN1

2666

Q9NU22
EDLLSHFYETGAFPP

LPGAT1

311

Q92604
VPHAHPATAEYEFAN

HSPB2

6

Q16082
FLTHPALFIEDHFPD

KY

306

Q8NBH2
HRIDFVAHDDIPYSS

PCYT1A

161

P49585
AAYEHPSHDLIFIFR

MMP13

336

P45452
VLPLEEAYRFHEFHS

EHD4

36

Q9H223
EAYRFHEFHSPALED

EHD4

41

Q9H223
DDSYHTFCLIPPLHD

KDM5B

331

Q9UGL1
PPSELLDHLFFHYEF

NLRX1

671

Q86UT6
SHHGEHERPEFIAYP

COX6A1

61

P12074
HRHSAFVPTRSYPEE

IRS1

571

P35568
PYTDFHYRHSPDTAE

RICTOR

256

Q6R327
YFAPDFTLHPDVSTR

HDAC3

331

O15379
NISLPEYFSEHFHEP

NOX4

236

Q9NPH5
EYFSEHFHEPFPEGF

NOX4

241

Q9NPH5
EDYFVPLHHFYLTPE

PARVB

296

Q9HBI1
SFHEDEVDRVPHNPY

FRMD4B

856

Q9Y2L6
AHNYQEDTVFFHLPP

AVL9

66

Q8NBF6
HQEPPHRYLISTYDD

CFAP107

86

Q8N1D5
VPHDETYCDPASLFH

ACE2

491

Q9BYF1
YVDPHTYEDPTQAVH

EPHA3

596

P29320
VRDHHDFLPYSTEPF

MAN2B2

341

Q9Y2E5
PFHDIPIYADKDVFH

PPA1

31

Q15181
HSSYFDLHDPPADVI

DENND4B

476

O75064
YRYQDEDAPHDHSLP

DLG2

16

Q15700
EDSVPYFPLDEHVDH

SDR42E2

161

A6NKP2
PISYEDFVNFPDIHH

FAM161A

76

Q3B820
HPYSRLPTSEDHYDD

ERVFC1

561

P60507
HTHRYGEPEVPESAF

RYR2

4466

Q92736
DLHRFHPEPYGLEDD

CTNND1

271

O60716
VALADHYTFSRPVHP

GPR132

351

Q9UNW8
LEFPAEFYPHIVSTD

MAP3K1

766

Q13233
YERFLPPDAFIHVDD

FUT3

281

P21217
SYHHLFPLDAFQEIP

GTF2H2C;

321

Q6P1K8
FYRFLDDEHEDAPLP

RAPGEF4

286

Q8WZA2
DVSTEHPPFYYNIHR

TRMT1L

626

Q7Z2T5
EELPRFILHYETHPF

PWWP3B

376

Q5H9M0
ISHQFPDYHDPTIED

RIT2

41

Q99578
LSHDHPPEYSADFYA

ORC5

191

O43913
APFHPYKRPFHEDVF

FOXN1

121

O15353
HTFYNELRVAPEEHP

POTEJ

751

P0CG39
LEFHSFPYSSDVDPD

SHLD1

46

Q8IYI0
EVFDPPHYELFSLRD

NETO2

391

Q8NC67
VRASPAFDYAEFEPH

SURF2

56

Q15527
AFDYAEFEPHIVPST

SURF2

61

Q15527
PFQIRHSDPESDFYR

SUPT7L

126

O94864
EHFYAREPEPFVLHH

TEX45

291

Q8NA69
QDDRPFFLYVAFHDP

SGSH

166

P51688
LLADEYTFAFPPHHD

SARDH

541

Q9UL12
IPIDGDFFSYTRHEP

ALDH2

161

P05091
YPHTHTFTALRFPEL

ROR1

341

Q01973
PDSAVNPEHLSYFHF

SMURF2

471

Q9HAU4
APEDPIFRFSSLHSY

STK19

86

P49842
SFTRSHPPLHEYADL

TGFBRAP1

396

Q8WUH2
EFHTPHDAAFFLSRP

THOC2

806

Q8NI27
PSPDFSFHADEYLEV

TDRKH

296

Q9Y2W6
FISHRFPEDHDPTIE

RIT1

41

Q92963
HRVPFFDQEDPDSYL

SPEM2

171

Q0P670
SYHHLFPLDAFQEIP

GTF2H2

321

Q13888
HEFIPTLYHFPTNCE

ROCK2

1261

O75116
HRAAYHPDFPTVLTA

SMC6

576

Q96SB8
PALSTSHPFYDVARH

ARHGAP8

6

P85298
DDPAVSRFQYPFHEL

TRPM1

601

Q7Z4N2
DSFYIRTHFELEPSP

TJP3

476

O95049
PEPDYSEFQSHPYHR

TMC5

106

Q6UXY8
PASHFETRPQTYVDH

WASF1

231

Q92558
HPDFPDDFSRPDDFH

WDR33

1006

Q9C0J8
EFFHHPFLDASPSVR

ULK1

271

O75385
EPLLFHSGDHYPLSD

LPIN2

211

Q92539
FRLPTDSHFPYDLHL

NEUROD6

306

Q96NK8