Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	antigen binding	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	1.78e-12	190	68	12	GO:0003823
GeneOntologyMolecularFunction	serine-type peptidase activity	PRSS3P2 KLK15 PRSS1 PRSS3 RELN PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.04e-10	207	68	11	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PRSS3P2 KLK15 PRSS1 PRSS3 RELN PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.34e-10	212	68	11	GO:0017171
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PRSS3P2 KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	8.65e-10	190	68	10	GO:0004252
GeneOntologyMolecularFunction	endopeptidase activity	PRSS3P2 KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.84e-06	430	68	10	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	PRSS3P2 KLK15 PRSS1 PRSS3 RELN PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.20e-05	654	68	11	GO:0008233
GeneOntologyMolecularFunction	POU domain binding	POU5F1 POU5F1B	2.37e-04	7	68	2	GO:0070974
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	5.05e-04	10	68	2	GO:0001849
GeneOntologyMolecularFunction	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	POU5F1 POU5F1B	8.70e-04	13	68	2	GO:0001162
GeneOntologyMolecularFunction	intronic transcription regulatory region sequence-specific DNA binding	POU5F1 POU5F1B	1.50e-03	17	68	2	GO:0001161
GeneOntologyMolecularFunction	NAD binding	HADHA IDH3G SIRT3	1.98e-03	73	68	3	GO:0051287
GeneOntologyMolecularFunction	NAD+ binding	HADHA SIRT3	2.09e-03	20	68	2	GO:0070403
GeneOntologyBiologicalProcess	immunoglobulin mediated immune response	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 C4A C4B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	3.74e-14	235	69	14	GO:0016064
GeneOntologyBiologicalProcess	B cell mediated immunity	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 C4A C4B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	6.28e-14	244	69	14	GO:0019724
GeneOntologyBiologicalProcess	immune effector process	IGHV3-53 IGHV3-48 RFTN1 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 CD22 INS UNC13D C4A C4B KLK5 KLK3 ITGAL IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	3.27e-13	859	69	21	GO:0002252
GeneOntologyBiologicalProcess	lymphocyte mediated immunity	IGHV3-53 IGHV3-48 RFTN1 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 UNC13D C4A C4B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	1.30e-12	449	69	16	GO:0002449
GeneOntologyBiologicalProcess	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	IGHV3-53 IGHV3-48 RFTN1 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 UNC13D C4A C4B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	2.00e-12	462	69	16	GO:0002460
GeneOntologyBiologicalProcess	leukocyte mediated immunity	IGHV3-53 IGHV3-48 RFTN1 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 UNC13D C4A C4B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	5.42e-11	576	69	16	GO:0002443
GeneOntologyBiologicalProcess	adaptive immune response	IGHV3-53 IGHV3-48 RFTN1 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B UNC13D C4A C4B SIPA1 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	1.86e-10	838	69	18	GO:0002250
GeneOntologyBiologicalProcess	tissue kallikrein-kinin cascade	KLK3 KLK2	3.30e-05	3	69	2	GO:0002255
GeneOntologyBiologicalProcess	trophectodermal cell fate commitment	POU5F1 POU5F1B	3.30e-05	3	69	2	GO:0001830
GeneOntologyBiologicalProcess	bradykinin biosynthetic process	KLK3 KLK2	6.59e-05	4	69	2	GO:0002936
GeneOntologyBiologicalProcess	zymogen activation	PRSS1 PRSS3 KLK3 KLK2	6.66e-05	65	69	4	GO:0031638
GeneOntologyBiologicalProcess	ectodermal cell fate commitment	POU5F1 POU5F1B	1.10e-04	5	69	2	GO:0001712
GeneOntologyBiologicalProcess	positive regulation of antibacterial peptide production	KLK5 KLK3	1.10e-04	5	69	2	GO:0002803
GeneOntologyBiologicalProcess	kinin cascade	KLK3 KLK2	1.64e-04	6	69	2	GO:0002254
GeneOntologyBiologicalProcess	positive regulation of antimicrobial peptide production	KLK5 KLK3	2.29e-04	7	69	2	GO:0002225
GeneOntologyBiologicalProcess	ectoderm formation	POU5F1 POU5F1B	2.29e-04	7	69	2	GO:0001705
GeneOntologyBiologicalProcess	left ventricular cardiac muscle tissue morphogenesis	KLK3 KLK2	2.29e-04	7	69	2	GO:0003220
GeneOntologyBiologicalProcess	positive regulation of antimicrobial humoral response	KLK5 KLK3	3.05e-04	8	69	2	GO:0002760
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	3.05e-04	8	69	2	GO:2000427
GeneOntologyBiologicalProcess	regulation of vesicle-mediated transport	MICAL1 ABCA2 PRTN3 CD22 UNC13D C4A C4B POU5F1 POU5F1B	3.67e-04	667	69	9	GO:0060627
GeneOntologyBiologicalProcess	ectodermal cell differentiation	POU5F1 POU5F1B	3.91e-04	9	69	2	GO:0010668
GeneOntologyBiologicalProcess	regulation of antibacterial peptide production	KLK5 KLK3	3.91e-04	9	69	2	GO:0002786
GeneOntologyBiologicalProcess	brain renin-angiotensin system	KLK3 KLK2	3.91e-04	9	69	2	GO:0002035
GeneOntologyBiologicalProcess	germ-line stem cell population maintenance	POU5F1 POU5F1B	4.88e-04	10	69	2	GO:0030718
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	4.88e-04	10	69	2	GO:2000425
GeneOntologyBiologicalProcess	endodermal cell fate specification	POU5F1 POU5F1B	5.95e-04	11	69	2	GO:0001714
GeneOntologyBiologicalProcess	negative regulation of calcium ion-dependent exocytosis	POU5F1 POU5F1B	5.95e-04	11	69	2	GO:0045955
GeneOntologyBiologicalProcess	regulation of antimicrobial peptide production	KLK5 KLK3	5.95e-04	11	69	2	GO:0002784
GeneOntologyBiologicalProcess	antibacterial peptide production	KLK5 KLK3	7.12e-04	12	69	2	GO:0002778
GeneOntologyBiologicalProcess	humoral immune response	PRSS3 PRTN3 C4A C4B KLK5 KLK3	7.13e-04	321	69	6	GO:0006959
GeneOntologyBiologicalProcess	collagen catabolic process	PRSS1 PRSS3 PRTN3	7.45e-04	53	69	3	GO:0030574
GeneOntologyBiologicalProcess	regulation of antimicrobial humoral response	KLK5 KLK3	9.78e-04	14	69	2	GO:0002759
GeneOntologyBiologicalProcess	antimicrobial peptide production	KLK5 KLK3	9.78e-04	14	69	2	GO:0002775
GeneOntologyBiologicalProcess	regulation of blood volume by renin-angiotensin	KLK3 KLK2	9.78e-04	14	69	2	GO:0002016
GeneOntologyCellularComponent	immunoglobulin complex	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	2.51e-13	166	69	12	GO:0019814
GeneOntologyCellularComponent	secretory granule	KLK15 PRSS3 ANGPTL6 PRTN3 IGF2R INS FAM220A KLK8 KLK12 UNC13D KLK5 KLK3 ITGAL KLK2	4.65e-06	1014	69	14	GO:0030141
GeneOntologyCellularComponent	blood microparticle	PRSS1 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B	8.07e-06	144	69	6	GO:0072562
GeneOntologyCellularComponent	tricarboxylic acid cycle heteromeric enzyme complex	BCKDHB IDH3G SUCLG1	2.71e-05	18	69	3	GO:0045239
GeneOntologyCellularComponent	secretory vesicle	KLK15 PRSS3 ANGPTL6 PRTN3 IGF2R INS FAM220A KLK8 KLK12 UNC13D KLK5 KLK3 ITGAL KLK2	4.68e-05	1246	69	14	GO:0099503
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	2.97e-04	8	69	2	GO:0106139
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL4A2 PRSS1 PRSS3 ANGPTL6 RELN PRTN3 COL16A1 INS	3.48e-04	530	69	8	GO:0062023
GeneOntologyCellularComponent	other organism part	C4A C4B	3.81e-04	9	69	2	GO:0044217
GeneOntologyCellularComponent	extracellular matrix	COL4A2 PRSS1 PRSS3 ANGPTL6 RELN PRTN3 COL16A1 INS	1.40e-03	656	69	8	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL4A2 PRSS1 PRSS3 ANGPTL6 RELN PRTN3 COL16A1 INS	1.42e-03	658	69	8	GO:0030312
GeneOntologyCellularComponent	mitochondrial matrix	OXCT1 BCKDHB HADHA IDH3G SUCLG1 NAXE SIRT3	1.67e-03	523	69	7	GO:0005759
HumanPheno	Unusual infection by anatomical site	PRTN3 CARMIL2 TNFRSF13B UNC13D C4A C4B	2.22e-05	114	27	6	HP:0032158
HumanPheno	Focal sensory seizure with vestibular features	MICAL1 RELN	8.09e-05	3	27	2	HP:0032759
HumanPheno	Phantosmia	MICAL1 RELN	8.09e-05	3	27	2	HP:0033693
HumanPheno	Focal sensory seizure with olfactory features	MICAL1 RELN	8.09e-05	3	27	2	HP:0011161
HumanPheno	Focal aware sensory seizure	MICAL1 RELN	1.61e-04	4	27	2	HP:0032754
HumanPheno	Focal aware non-motor seizure	MICAL1 RELN	1.61e-04	4	27	2	HP:0032682
HumanPheno	Focal sensory seizure with cephalic sensation	MICAL1 RELN	1.61e-04	4	27	2	HP:0032810
HumanPheno	Focal aware sensory seizure with auditory features	MICAL1 RELN	1.61e-04	4	27	2	HP:0032864
HumanPheno	Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole	MICAL1 RELN	1.61e-04	4	27	2	HP:0032773
HumanPheno	Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	MICAL1 RELN	1.61e-04	4	27	2	HP:0011159
HumanPheno	Focal sensory seizure with auditory features	MICAL1 RELN	1.61e-04	4	27	2	HP:0011158
HumanPheno	Unusual CNS infection	PRTN3 TNFRSF13B UNC13D C4A C4B	2.17e-04	108	27	5	HP:0011450
HumanPheno	Focal sensory seizure with visual features	MICAL1 RELN	4.01e-04	6	27	2	HP:0011165
MousePheno	renal glomerular protein deposits	INS TNFRSF13B C4A C4B	1.85e-05	42	53	4	MP:0020518
MousePheno	abnormal interventricular septum thickness	IGF2R INS KLK3 KLK2	5.84e-05	56	53	4	MP:0020136
MousePheno	abnormal uterine artery morphology	KLK3 KLK2	1.40e-04	5	53	2	MP:0003995
MousePheno	increased anti-double stranded DNA antibody level	CD22 TNFRSF13B C4A C4B	1.40e-04	70	53	4	MP:0004762
MousePheno	increased autoantibody level	CD22 INS TNFRSF13B C4A C4B	1.44e-04	133	53	5	MP:0003725
Domain	TRYPSIN_HIS	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	2.02e-11	103	56	9	IPR018114
Domain	TRYPSIN_SER	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	2.62e-11	106	56	9	PS00135
Domain	TRYPSIN_HIS	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	2.86e-11	107	56	9	PS00134
Domain	Peptidase_S1A	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	4.70e-11	113	56	9	IPR001314
Domain	TRYPSIN_DOM	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	5.51e-11	115	56	9	PS50240
Domain	Tryp_SPc	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	6.44e-11	117	56	9	SM00020
Domain	Trypsin	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	8.72e-11	121	56	9	PF00089
Domain	Trypsin_dom	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	8.72e-11	121	56	9	IPR001254
Domain	Peptidase_S1_PA	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.01e-10	123	56	9	IPR009003
Domain	TRYPSIN_SER	PRSS1 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	9.11e-09	90	56	7	IPR033116
Domain	POU_dom_5	POU5F1 POU5F1B	2.64e-05	3	56	2	IPR015585
Domain	Anaphylatoxin_comp_syst	C4A C4B	8.78e-05	5	56	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	8.78e-05	5	56	2	IPR001840
Domain	ANATO	C4A C4B	1.84e-04	7	56	2	SM00104
Domain	ANATO	C4A C4B	1.84e-04	7	56	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	1.84e-04	7	56	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.84e-04	7	56	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	1.84e-04	7	56	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	2.44e-04	8	56	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	2.44e-04	8	56	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	2.44e-04	8	56	2	IPR019742
Domain	A2M_N	C4A C4B	3.91e-04	10	56	2	PF01835
Domain	A2M_N	C4A C4B	3.91e-04	10	56	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	3.91e-04	10	56	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	3.91e-04	10	56	2	PS00477
Domain	A2M	C4A C4B	3.91e-04	10	56	2	PF00207
Domain	A2M_N_2	C4A C4B	3.91e-04	10	56	2	IPR011625
Domain	A2M_comp	C4A C4B	3.91e-04	10	56	2	IPR011626
Domain	A2M_N_2	C4A C4B	3.91e-04	10	56	2	PF07703
Domain	A2M_recep	C4A C4B	3.91e-04	10	56	2	PF07677
Domain	A2M_comp	C4A C4B	3.91e-04	10	56	2	PF07678
Domain	Macroglobln_a2	C4A C4B	3.91e-04	10	56	2	IPR001599
Domain	Integrin_alpha	ITGA7 ITGAL	4.77e-04	11	56	2	PF00357
Domain	ABC_A	ABCA2 ABCA4	5.72e-04	12	56	2	IPR026082
Domain	POU	POU5F1 POU5F1B	1.03e-03	16	56	2	SM00352
Domain	POU_2	POU5F1 POU5F1B	1.03e-03	16	56	2	PS00465
Domain	POU_dom	POU5F1 POU5F1B	1.03e-03	16	56	2	IPR000327
Domain	Integrin_alpha_C_CS	ITGA7 ITGAL	1.03e-03	16	56	2	IPR018184
Domain	POU_3	POU5F1 POU5F1B	1.03e-03	16	56	2	PS51179
Domain	Pou	POU5F1 POU5F1B	1.03e-03	16	56	2	PF00157
Domain	POU_1	POU5F1 POU5F1B	1.03e-03	16	56	2	PS00035
Domain	C345C	C4A C4B	1.17e-03	17	56	2	SM00643
Domain	POU	POU5F1 POU5F1B	1.17e-03	17	56	2	IPR013847
Domain	Integrin_alpha-2	ITGA7 ITGAL	1.31e-03	18	56	2	IPR013649
Domain	Integrin_alpha2	ITGA7 ITGAL	1.31e-03	18	56	2	PF08441
Domain	Integrin_alpha	ITGA7 ITGAL	1.31e-03	18	56	2	IPR000413
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.31e-03	18	56	2	IPR008930
Domain	INTEGRIN_ALPHA	ITGA7 ITGAL	1.31e-03	18	56	2	PS00242
Domain	Int_alpha_beta-p	ITGA7 ITGAL	1.46e-03	19	56	2	IPR013519
Domain	NTR	C4A C4B	1.46e-03	19	56	2	PF01759
Domain	Int_alpha	ITGA7 ITGAL	1.46e-03	19	56	2	SM00191
Domain	Netrin_module_non-TIMP	C4A C4B	1.46e-03	19	56	2	IPR018933
Domain	FG_GAP	ITGA7 ITGAL	1.96e-03	22	56	2	PS51470
Domain	NTR	C4A C4B	2.15e-03	23	56	2	PS50189
Domain	Netrin_domain	C4A C4B	2.15e-03	23	56	2	IPR001134
Domain	FG-GAP	ITGA7 ITGAL	2.34e-03	24	56	2	PF01839
Domain	FG-GAP	ITGA7 ITGAL	2.34e-03	24	56	2	IPR013517
Domain	Integrin_dom	ITGA7 ITGAL	2.53e-03	25	56	2	IPR032695
Domain	TIMP-like_OB-fold	C4A C4B	2.74e-03	26	56	2	IPR008993
Domain	-	POU5F1 POU5F1B	2.95e-03	27	56	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU5F1 POU5F1B	3.40e-03	29	56	2	IPR010982
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B IGHV3-74 IGHV3-66 IGHV3-64D	3.20e-15	54	51	10	MM14655
Pathway	REACTOME_CD22_MEDIATED_BCR_REGULATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 IGHV3-74 IGHV3-66 IGHV3-64D	3.31e-15	35	51	9	MM17219
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 IGHV3-74 IGHV3-66 IGHV3-64D	1.98e-13	53	51	9	MM15716
Pathway	REACTOME_COMPLEMENT_CASCADE	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B IGHV3-74 IGHV3-66 IGHV3-64D	3.41e-13	84	51	10	MM14653
Pathway	REACTOME_CLASSICAL_ANTIBODY_MEDIATED_COMPLEMENT_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	9.33e-13	39	51	8	MM17212
Pathway	REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	3.22e-12	45	51	8	MM14912
Pathway	REACTOME_FCGR_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	5.58e-12	48	51	8	MM17214
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	2.06e-11	56	51	8	MM14815
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	2.76e-11	58	51	8	MM14914
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	3.66e-11	60	51	8	MM14913
Pathway	REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	3.66e-11	60	51	8	MM14872
Pathway	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 ITGAL IGHV3-74 IGHV3-66 IGHV3-64D	4.24e-11	135	51	10	MM14781
Pathway	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 IGHV3-74 IGHV3-66 IGHV3-64D	8.57e-10	131	51	9	MM15717
Pathway	REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	4.11e-09	107	51	8	MM14915
Pathway	REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 ITGAL IGHV3-74 IGHV3-66 IGHV3-64D	4.52e-09	158	51	9	MM14812
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	6.80e-09	114	51	8	MM14814
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B	1.37e-08	80	51	7	M6121
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	5.89e-08	150	51	8	MM14889
Pathway	REACTOME_CD22_MEDIATED_BCR_REGULATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22	7.90e-08	61	51	6	M27581
Pathway	REACTOME_COMPLEMENT_CASCADE	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B	1.72e-07	115	51	7	M19752
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	IGHV3-53 IGHV3-48 PRSS1 PRSS3 PRTN3 IGF2R IGHV3-23 IGHV3-13 IGHV3-7 UNC13D C4A C4B ITGAL IGHV3-74 IGHV3-66 IGHV3-64D	2.30e-07	995	51	16	MM14661
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22	6.24e-07	86	51	6	M601
Pathway	REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS	IGHV3-53 COL4A2 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.35e-06	98	51	6	M27152
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL4A2 PRSS1 PRSS3 COL16A1 ITGA7 KLK3 ITGAL KLK2	3.64e-06	258	51	8	MM14572
Pathway	REACTOME_HEMOSTASIS	IGHV3-53 IGHV3-48 PRTN3 IGHV3-23 IGHV3-13 IGHV3-7 ITGAL KIFC2 IGHV3-74 IGHV3-66 IGHV3-64D	4.76e-06	571	51	11	MM14472
Pathway	REACTOME_FCGR_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	4.78e-06	69	51	5	M27108
Pathway	REACTOME_SCAVENGING_OF_HEME_FROM_PLASMA	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	4.78e-06	69	51	5	M27150
Pathway	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 ITGAL	5.07e-06	190	51	7	M8240
Pathway	REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	5.51e-06	71	51	5	M1078
Pathway	REACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	5.51e-06	71	51	5	M27203
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 HERC2 SIPA1 ITGAL IGHV3-74 IGHV3-66 IGHV3-64D	7.15e-06	719	51	12	MM14540
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	PRSS1 PRSS3 KLK3 KLK2	1.02e-05	38	51	4	MM14611
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.12e-05	82	51	5	M27110
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.42e-05	86	51	5	M27206
Pathway	REACTOME_FCERI_MEDIATED_MAPK_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.50e-05	87	51	5	M27205
Pathway	REACTOME_VESICLE_MEDIATED_TRANSPORT	IGHV3-53 IGHV3-48 IGF2R IGHV3-23 IGHV3-13 IGHV3-7 INS KIFC2 IGHV3-74 IGHV3-66 IGHV3-64D	1.51e-05	645	51	11	MM15232
Pathway	REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	2.30e-05	95	51	5	M29842
Pathway	REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22	2.83e-05	166	51	6	M608
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL4A2 PRSS1 PRSS3 KLK3 KLK2	5.53e-05	114	51	5	MM14571
Pathway	REACTOME_PARASITE_INFECTION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	6.01e-05	116	51	5	M29843
Pathway	REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 ITGAL	6.76e-05	194	51	6	M16312
Pathway	REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.19e-04	134	51	5	M29840
Pathway	REACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.28e-04	136	51	5	M27207
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.62e-04	143	51	5	M27107
Pathway	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	IDH3G SUCLG1 SIRT3	2.25e-04	33	51	3	MM15407
Pathway	REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	2.28e-04	154	51	5	M39007
Pathway	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	IDH3G SUCLG1 SIRT3	2.47e-04	34	51	3	M784
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL4A2 COL16A1 ITGA7 ITGAL	2.48e-04	85	51	4	M16441
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	2.66e-04	7	51	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	3.54e-04	8	51	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	3.54e-04	8	51	2	M47872
Pathway	WP_MIRNAS_AND_TFS_IN_IPS_CELL_GENERATION	POU5F1 POU5F1B	3.54e-04	8	51	2	MM15855
Pathway	KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	OXCT1 BCKDHB HADHA	5.32e-04	44	51	3	M11835
Pathway	REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	5.44e-04	186	51	5	M27175
Pathway	REACTOME_INNATE_IMMUNE_SYSTEM	IGHV3-53 IGHV3-48 PRSS3 PRTN3 IGF2R IGHV3-23 IGHV3-13 IGHV3-7 UNC13D C4A C4B ITGAL	5.51e-04	1128	51	12	M1036
Pathway	REACTOME_UPTAKE_OF_DIETARY_COBALAMINS_INTO_ENTEROCYTES	PRSS1 PRSS3	5.67e-04	10	51	2	M45024
Pathway	REACTOME_HEMOSTASIS	IGHV3-53 IGHV3-48 MICAL1 PRTN3 IGHV3-23 IGHV3-13 IGHV3-7 ITGAL KIFC2	6.53e-04	679	51	9	M8395
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	6.91e-04	11	51	2	MM1430
Pathway	REACTOME_ALPHA_DEFENSINS	PRSS1 PRSS3	6.91e-04	11	51	2	MM14569
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	6.91e-04	11	51	2	M47874
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL4A2 PRSS1 COL16A1 ITGA7 ITGAL KLK2	7.11e-04	300	51	6	M610
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	8.28e-04	12	51	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	9.76e-04	13	51	2	M4732
Pathway	REACTOME_VESICLE_MEDIATED_TRANSPORT	IGHV3-53 COL4A2 IGHV3-48 IGF2R IGHV3-23 IGHV3-13 IGHV3-7 INS KIFC2	1.04e-03	725	51	9	M27507
Pathway	REACTOME_LEISHMANIA_INFECTION	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7	1.14e-03	219	51	5	M29836
Pathway	BIOCARTA_CDK5_PATHWAY	KLK3 KLK2	1.14e-03	14	51	2	MM1457
Pathway	BIOCARTA_TRKA_PATHWAY	KLK3 KLK2	1.31e-03	15	51	2	MM1523
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 ITGA7	1.31e-03	15	51	2	MM14922
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.31e-03	15	51	2	M7146
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL4A2 PRSS1 COL16A1 KLK2	1.62e-03	140	51	4	M587
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.69e-03	17	51	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.69e-03	17	51	2	MM1369
Pathway	WP_TCA_CYCLE_AKA_KREBS_OR_CITRIC_ACID_CYCLE	IDH3G SUCLG1	1.89e-03	18	51	2	M39460
Pathway	REACTOME_ANTIMICROBIAL_PEPTIDES	PRSS1 PRSS3 PRTN3	2.06e-03	70	51	3	MM15332
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	2.34e-03	20	51	2	M917
Pathway	WP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS	C4A C4B POU5F1 HADHA	2.58e-03	159	51	4	M39373
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL4A2 COL16A1 ITGAL	2.60e-03	76	51	3	MM14867
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 CD22 HERC2 SIPA1 ITGAL	2.61e-03	828	51	9	M1058
Pathway	BIOCARTA_NGF_PATHWAY	KLK3 KLK2	2.83e-03	22	51	2	MM1440
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	2.83e-03	22	51	2	M39502
Pathway	REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM	PRSS1 PRSS3	2.83e-03	22	51	2	M27084
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	COL4A2 RELN ITGA7	3.46e-03	84	51	3	M7098
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KLK8 KLK12 KLK5	3.82e-03	87	51	3	MM15351
Pathway	PID_INTEGRIN_CS_PATHWAY	ITGA7 ITGAL	3.95e-03	26	51	2	M47
Pathway	BIOCARTA_ERK_PATHWAY	KLK3 KLK2	4.57e-03	28	51	2	MM1391
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	COL4A2 RELN INS ITGA7 ITGAL	4.58e-03	302	51	5	M39719
Pathway	WP_FOCAL_ADHESION	COL4A2 RELN ITGA7 ITGAL	4.61e-03	187	51	4	MM15913
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 ITGA7	5.23e-03	30	51	2	M27216
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	INS SIRT3	5.23e-03	30	51	2	M27941
Pathway	REACTOME_DEFENSINS	PRSS1 PRSS3	5.58e-03	31	51	2	MM14568
Pathway	WP_TCA_CYCLE	IDH3G SUCLG1	5.58e-03	31	51	2	MM15856
Pathway	KEGG_CITRATE_CYCLE_TCA_CYCLE	IDH3G SUCLG1	5.58e-03	31	51	2	M3985
Pathway	KEGG_PROPANOATE_METABOLISM	HADHA SUCLG1	6.31e-03	33	51	2	M4086
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	PRSS1 KLK2	6.31e-03	33	51	2	M26976
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	COL4A2 RELN INS ITGA7 ITGAL	6.31e-03	326	51	5	MM15917
Pathway	WP_FATTY_ACID_BETAOXIDATION	GK2 HADHA	6.69e-03	34	51	2	M39596
Pathway	KEGG_BUTANOATE_METABOLISM	OXCT1 HADHA	6.69e-03	34	51	2	M3397
Pathway	WP_FATTY_ACID_BETAOXIDATION	GK2 HADHA	6.69e-03	34	51	2	MM15937
Pubmed	1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	1.00e-18	15	69	8	12657787
Pubmed	Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	4.93e-17	22	69	8	2499654
Pubmed	IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	4.72e-16	77	69	10	15608191
Pubmed	Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.45e-13	14	69	6	25666037
Pubmed	Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.45e-13	14	69	6	11054574
Pubmed	The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-16 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66	1.91e-13	91	69	9	9841928
Pubmed	Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	2.41e-13	15	69	6	15203212
Pubmed	Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	2.41e-13	15	69	6	16800723
Pubmed	A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	2.41e-13	15	69	6	16800724
Pubmed	Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	3.85e-13	16	69	6	20424135
Pubmed	Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.	KLK8 KLK12 KLK5 KLK3 KLK2	5.55e-13	7	69	5	10969073
Pubmed	Organization and evolution of the glandular kallikrein locus in Mus musculus.	KLK15 KLK12 KLK5 KLK3 KLK2	6.63e-12	10	69	5	12437987
Pubmed	Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus.	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7	1.51e-10	39	69	6	8490662
Pubmed	The new human kallikrein gene family: implications in carcinogenesis.	KLK15 KLK12 KLK5 KLK3	2.12e-10	6	69	4	10675891
Pubmed	Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.	KLK8 KLK5 KLK3 KLK2	2.95e-09	10	69	4	19558318
Pubmed	A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.	KLK15 KLK3 KLK2	7.47e-09	3	69	3	19823874
Pubmed	Human tissue kallikreins: physiologic roles and applications in cancer.	KLK15 KLK8 KLK12 KLK5	1.00e-08	13	69	4	15192120
Pubmed	Mapping of 12 markers in the proximal region of mouse chromosome 17 using recombinant t haplotypes.	C4A C4B POU5F1 POU5F1B	1.90e-08	15	69	4	7749235
Pubmed	Lineage allocation and asymmetries in the early mouse embryo.	POU5F1 POU5F1B ITGA7	2.99e-08	4	69	3	14511480
Pubmed	Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.	KLK8 KLK3 KLK2	2.99e-08	4	69	3	7623137
Pubmed	Determination of allelic expression of h19 in pre- and peri-implantation mouse embryos.	POU5F1 POU5F1B ITGA7	7.45e-08	5	69	3	23486912
Pubmed	Molecular analysis of spontaneous somatic mutants.	IGHV3-48 IGHV3-13 IGHV3-7	7.45e-08	5	69	3	401950
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	KLK15 KLK8 KLK3 KLK2	8.28e-08	21	69	4	19592578
Pubmed	Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.	PRSS1 IGHV3-23 IGHV3-13 IGHV3-7 C4A C4B	4.21e-07	143	69	6	22516433
Pubmed	A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.	KLK15 INS KLK3 KLK2	7.09e-07	35	69	4	23936387
Pubmed	Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.	PRSS3 INS KLK3 KLK2	7.96e-07	36	69	4	6690234
Pubmed	Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.	IGHV3-13 IGHV3-72 IGHV3-66	8.88e-07	10	69	3	3396540
Pubmed	Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans.	KLK15 KLK3 KLK2	1.22e-06	11	69	3	19902474
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL4A2 PRSS1 PRSS3 RELN COL16A1 INS	1.37e-06	175	69	6	28071719
Pubmed	Susceptibility loci associated with prostate cancer progression and mortality.	KLK15 KLK3 KLK2	1.62e-06	12	69	3	20460480
Pubmed	Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.	POU5F1 POU5F1B ITGA7	1.62e-06	12	69	3	15788452
Pubmed	Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb.	IGF2R POU5F1 POU5F1B	2.68e-06	14	69	3	11641723
Pubmed	Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome.	IGF2R POU5F1 POU5F1B	3.34e-06	15	69	3	26267271
Pubmed	Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.	INS KLK3 KLK2	3.34e-06	15	69	3	1460423
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	3.88e-06	2	69	2	22737222
Pubmed	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.	KLK3 KLK2	3.88e-06	2	69	2	24270797
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	3.88e-06	2	69	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	3.88e-06	2	69	2	15998580
Pubmed	Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage.	POU5F1 POU5F1B	3.88e-06	2	69	2	31843009
Pubmed	Characterization of novel alternative splicing variants of Oct4 gene expressed in mouse pluripotent stem cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	29266259
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	3.88e-06	2	69	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	3.88e-06	2	69	2	19062096
Pubmed	Detection of prostate specific transcripts in the peripheral blood during brachytherapy predicts postoperative PSA kinetics.	KLK3 KLK2	3.88e-06	2	69	2	19434652
Pubmed	Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression.	POU5F1 POU5F1B	3.88e-06	2	69	2	15685634
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	3.88e-06	2	69	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	3.88e-06	2	69	2	1357031
Pubmed	Regulatory Elements Outside Established Pou5f1 Gene Boundaries Are Required for Multilineage Differentiation of Embryonic Stem Cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	37895112
Pubmed	Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.	POU5F1 POU5F1B	3.88e-06	2	69	2	16950240
Pubmed	Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.	POU5F1 POU5F1B	3.88e-06	2	69	2	18837968
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	3.88e-06	2	69	2	16098595
Pubmed	[Investigation of transcriptional regulation of Oct4 (POU5F1) gene with distal enhancer].	POU5F1 POU5F1B	3.88e-06	2	69	2	25509123
Pubmed	Cruciform Formable Sequences within Pou5f1 Enhancer Are Indispensable for Mouse ES Cell Integrity.	POU5F1 POU5F1B	3.88e-06	2	69	2	33810223
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	3.88e-06	2	69	2	19933335
Pubmed	Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.	POU5F1 POU5F1B	3.88e-06	2	69	2	18063756
Pubmed	Neural stem cells express Oct-3/4.	POU5F1 POU5F1B	3.88e-06	2	69	2	19664601
Pubmed	Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency.	POU5F1 POU5F1B	3.88e-06	2	69	2	28157483
Pubmed	Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines.	POU5F1 POU5F1B	3.88e-06	2	69	2	19784378
Pubmed	Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.	POU5F1 POU5F1B	3.88e-06	2	69	2	28988986
Pubmed	Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos.	POU5F1 POU5F1B	3.88e-06	2	69	2	18932201
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	3.88e-06	2	69	2	2459207
Pubmed	A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.	POU5F1 POU5F1B	3.88e-06	2	69	2	1972777
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	3.88e-06	2	69	2	17645767
Pubmed	Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.	KLK12 KLK5	3.88e-06	2	69	2	23612974
Pubmed	The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.	POU5F1 POU5F1B	3.88e-06	2	69	2	1915274
Pubmed	The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: towards a biologically-based screening strategy.	KLK3 KLK2	3.88e-06	2	69	2	17657743
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	3.88e-06	2	69	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	3.88e-06	2	69	2	12207352
Pubmed	Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex.	POU5F1 POU5F1B	3.88e-06	2	69	2	1680810
Pubmed	Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	20376339
Pubmed	Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.	POU5F1 POU5F1B	3.88e-06	2	69	2	30653498
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	3.88e-06	2	69	2	30026462
Pubmed	Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.	POU5F1 POU5F1B	3.88e-06	2	69	2	15996113
Pubmed	Dual roles of Oct4 in the maintenance of mouse P19 embryonal carcinoma cells: as negative regulator of Wnt/β-catenin signaling and competence provider for Brachyury induction.	POU5F1 POU5F1B	3.88e-06	2	69	2	21083502
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	3.88e-06	2	69	2	6559257
Pubmed	Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis.	PRSS3P2 PRSS1	3.88e-06	2	69	2	25546417
Pubmed	Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.	POU5F1 POU5F1B	3.88e-06	2	69	2	26804242
Pubmed	Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.	POU5F1 POU5F1B	3.88e-06	2	69	2	21502535
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	3.88e-06	2	69	2	27758680
Pubmed	Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy.	KLK3 KLK2	3.88e-06	2	69	2	19003994
Pubmed	OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.	POU5F1 POU5F1B	3.88e-06	2	69	2	27499297
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	3.88e-06	2	69	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	3.88e-06	2	69	2	34299197
Pubmed	Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	11839818
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	3.88e-06	2	69	2	20506482
Pubmed	Role of Organic Cation Transporter 3 and Plasma Membrane Monoamine Transporter in the Rewarding Properties and Locomotor Sensitizing Effects of Amphetamine in Male andFemale Mice.	POU5F1 POU5F1B	3.88e-06	2	69	2	34948221
Pubmed	A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.	POU5F1 POU5F1B	3.88e-06	2	69	2	33221301
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	3.88e-06	2	69	2	12480675
Pubmed	Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences.	POU5F1 POU5F1B	3.88e-06	2	69	2	11309664
Pubmed	Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.	POU5F1 POU5F1B	3.88e-06	2	69	2	12641567
Pubmed	A nontranscriptional role for Oct4 in the regulation of mitotic entry.	POU5F1 POU5F1B	3.88e-06	2	69	2	25324523
Pubmed	A novel subpopulation lacking Oct4 expression in the testicular side population.	POU5F1 POU5F1B	3.88e-06	2	69	2	16328007
Pubmed	PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.	PRSS3 KLK5	3.88e-06	2	69	2	30755669
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	3.88e-06	2	69	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	3.88e-06	2	69	2	23749435
Pubmed	Novel variants of Oct-3/4 gene expressed in mouse somatic cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	18765667
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	3.88e-06	2	69	2	23918728
Pubmed	Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.	POU5F1 POU5F1B	3.88e-06	2	69	2	18283123
Pubmed	Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.	POU5F1 POU5F1B	3.88e-06	2	69	2	22832160
Pubmed	De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4.	POU5F1 POU5F1B	3.88e-06	2	69	2	16932739
Pubmed	Mechanisms of OCT4 on 3,5,3'-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice.	POU5F1 POU5F1B	3.88e-06	2	69	2	34463738
Cytoband	14q32.33	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66	5.04e-14	228	69	11	14q32.33
Cytoband	Ensembl 112 genes in cytogenetic band chr14q32	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 SLC25A47 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	2.73e-12	566	69	13	chr14q32
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	KLK15 KCNA7 CD22 KLK8 KLK12 KLK5 KLK3 KLK2 SYNE4	7.29e-05	1192	69	9	chr19q13
Cytoband	19q13.41	KLK15 KLK3 KLK2	2.28e-04	78	69	3	19q13.41
Cytoband	11p15.5	RNH1 INS SIRT3	7.66e-04	118	69	3	11p15.5
GeneFamily	Kallikreins	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	2.57e-12	16	50	6	616
GeneFamily	Immunoglobulin heavy locus at 14q32.33	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66	2.84e-12	187	50	11	349
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	2.67e-04	9	50	2	1234
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA4	6.68e-04	14	50	2	805
GeneFamily	Proteases, serine	PRSS1 PRSS3 KLK8	7.03e-04	63	50	3	738
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA7 ITGAL	1.11e-03	18	50	2	1160
GeneFamily	POU class homeoboxes and pseudogenes	POU5F1 POU5F1B	1.83e-03	23	50	2	523
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	4.45e-03	36	50	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	4.69e-03	37	50	2	454
GeneFamily	Collagens	COL4A2 COL16A1	7.18e-03	46	50	2	490
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGF2R CD22 TNFRSF13B ITGAL	2.33e-02	394	50	4	471
Coexpression	XU_CREBBP_TARGETS_DN	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	1.52e-12	56	67	8	MM642
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	2.15e-10	102	67	8	MM872
Coexpression	RASHI_RESPONSE_TO_IONIZING_RADIATION_6	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-66 IGHV3-64D	1.70e-09	132	67	8	MM996
Coexpression	SALVADOR_MARTIN_PEDIATRIC_TBD_ANTI_TNF_THERAPY_NONRESPONDER_POST_TREATMENT_DN	IGHV3-48 IGHV3-7 IGHV3-74	8.73e-06	16	67	3	M41742
Coexpression	WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP	PRSS1 PRSS3 KLK3 KLK2	6.45e-05	84	67	4	MM1049
Coexpression	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	GAS8 KLK8 POU5F1 POU5F1B KLK3 KLK2 NAXE SIRT3 IGHV3-73 IGHV3-72	6.96e-05	871	67	10	MM1005
Coexpression	HUTTMANN_B_CLL_POOR_SURVIVAL_UP	PRSS3 PTPRCAP RNH1 C4A ITGAL KLK2	8.80e-05	284	67	6	M19993
Coexpression	MOOTHA_HUMAN_MITODB_6_2002	OXCT1 MAST1 BCKDHB HADHA IDH3G SUCLG1 SDS	1.17e-04	432	67	7	M9433
Coexpression	GSE21927_SPLEEN_VS_BONE_MARROW_MONOCYTE_BALBC_UP	COL4A2 RFTN1 IGF2R MAST1 KLHDC8B	1.47e-04	196	67	5	M7562
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_DN	NKX2-8 ABCA2 PTPRCAP CD22 ITGAL	1.58e-04	199	67	5	M5249
Coexpression	GSE22432_UNTREATED_VS_TGFB1_TREATED_COMMON_DC_PROGENITOR_DN	TNFRSF13B UNC13D BCKDHB HERC2 ITGAL	1.62e-04	200	67	5	M7828
Coexpression	GSE24210_RESTING_TREG_VS_TCONV_UP	CD22 UNC13D HERC2 SIPA1 ITGAL	1.62e-04	200	67	5	M7839
Coexpression	SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12	IGHV3-23 OXCT1 IGHV3-7 MAST1 IGHV3-73 IGHV3-72	1.63e-04	318	67	6	M2429
Coexpression	VANASSE_BCL2_TARGETS_UP	RELN IGHV3-73 IGHV3-72	1.83e-04	43	67	3	MM799
Coexpression	TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN	PRTN3 OXCT1 PTPRCAP TNFRSF13B BCKDHB ITGAL	1.90e-04	327	67	6	M2351
CoexpressionAtlas	AravindRamakr_StemCell_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000_k-means-cluster#5	IGHV3-48 IGHV3-23 IGHV3-7 IGHV3-74 IGHV3-72 IGHV3-66	1.71e-05	183	63	6	Arv_SC_fibroblast_1000_K5
CoexpressionAtlas	AravindRamakr_StemCell-HD_top-relative-expression-ranked_1000_k-means-cluster#3	IGHV3-48 IGHV3-23 IGHV3-7 IGHV3-74 IGHV3-72 IGHV3-66	1.71e-05	183	63	6	Arv_SC-HD_1000_K3
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	7.07e-15	190	68	11	79ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66 IGHV3-64D	7.07e-15	190	68	11	18762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-7 TROAP TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66	8.91e-15	194	68	11	6ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.06e-14	197	68	11	2662138671262b30508c5759038bcdcfe6551696
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22 TNFRSF13B IGHV3-74 IGHV3-66	1.74e-13	178	68	10	107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72	3.91e-13	193	68	10	7b4b0271e4fbece703876acb053ae236afb7cdba
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-66	4.33e-13	195	68	10	f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCell	Biopsy_IPF-Immune-Plasma_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	4.56e-13	196	68	10	a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72	8.21e-12	179	68	9	837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72	8.21e-12	179	68	9	b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-66 IGHV3-64D	9.08e-12	181	68	9	e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCell	Mild-Lymphoid-B\|Mild / Condition, Lineage, Cell class and cell subclass	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-72 IGHV3-66 IGHV3-64D	1.00e-11	183	68	9	9b64d2d143525e6f48a191facfd101462ff36324
ToppCell	Mild_COVID-19-B_cell\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-73 IGHV3-66	1.00e-11	183	68	9	dea119e2988e954475f557f0bbe12556a83e81a4
ToppCell	Mild-Lymphoid-B-\|Mild / Condition, Lineage, Cell class and cell subclass	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-72 IGHV3-66 IGHV3-64D	1.00e-11	183	68	9	b5740f05a4dcdbbf24f7bf7a3f57ac01a5e75f60
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	1.10e-11	185	68	9	08bc817908076734d66f2805cb954141f2cc5a18
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	1.10e-11	185	68	9	1704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell	10x5'-Liver-Lymphocytic_B_plasma\|Liver / Manually curated celltypes from each tissue	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-64D	1.16e-11	186	68	9	a2c7430781f432c9c90ac4d620f4518ff767a223
ToppCell	Mild_COVID-19-B_cell-B_cell\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-73 IGHV3-66	1.16e-11	186	68	9	855a5a00ba2aa1b5c63b8db56d026ddecc546050
ToppCell	healthy_donor-Lymphocytic-Plasma_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	1.28e-11	188	68	9	bd53b0371154cff680226897b61c9809a239d1b6
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-23 IGHV3-13 IGHV3-7 TROAP TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.28e-11	188	68	9	6844cebca177fdf38b21a40d606230a033717a3a
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.62e-11	193	68	9	282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCell	COVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.85e-11	196	68	9	026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	1.85e-11	196	68	9	fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.94e-11	197	68	9	1e63879633f20646e44873ae6b662f6faf4806fd
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	1.94e-11	197	68	9	da175e66d0a743a1b91d46f224b5ff1d37aa5410
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22 TNFRSF13B IGHV3-66	1.94e-11	197	68	9	9fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-35 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72	8.77e-11	152	68	8	a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-73 IGHV3-64D	2.47e-10	173	68	8	0ca2169a275404118038c0489a48062879488765
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74	2.96e-10	177	68	8	4c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell	10x5'-Liver-Lymphocytic_B_plasma-Plasmablasts\|Liver / Manually curated celltypes from each tissue	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 TROAP TNFRSF13B IGHV3-66 IGHV3-64D	2.96e-10	177	68	8	1d88ae316d65ca5fdc736c9da93885b6b40c32bb
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74	2.96e-10	177	68	8	d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74	2.96e-10	177	68	8	fc40918825b7e1eb6861df59dfca944778a64b98
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-72	3.23e-10	179	68	8	494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	3.86e-10	183	68	8	5ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell	10x5'-Liver-Lymphocytic_B_plasma-Plasma_cells\|Liver / Manually curated celltypes from each tissue	IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-73 IGHV3-72 IGHV3-64D	4.03e-10	184	68	8	6f70d8f8ab8362d51f8a58735d42223e06566397
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-66 IGHV3-64D	4.20e-10	185	68	8	609080adb2cfb105bb7b8efb617553833299f371
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72 IGHV3-66	5.88e-10	193	68	8	34f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-66	6.12e-10	194	68	8	a4a70369541876e1192df8828b63e3d1746ae3d9
ToppCell	Biopsy_Other_PF-Immune-Plasma_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-66	6.38e-10	195	68	8	d0305c6a68c9e361507b04db94f86873085d49b3
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-72	6.38e-10	195	68	8	df009b18898c10686f75cf72b4ec0eff18f5bb50
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B IGHV3-74 IGHV3-66	6.92e-10	197	68	8	0e56255862fed099e771ebd2529393dc5a3641ba
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22 IGHV3-74 IGHV3-73	7.20e-10	198	68	8	79c690d21d3420d0bb1a3b3b4ea2c9aa3810a219
ToppCell	10x5'-blood-Lymphocytic_B_plasma\|blood / Manually curated celltypes from each tissue	IGHV3-48 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B KLK2 IGHV3-74	3.25e-09	150	68	7	6bab0a8bf78ed7de9e1b67ede7496488f80f4863
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 TNFRSF13B IGHV3-74 IGHV3-66	6.58e-09	166	68	7	2b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74	8.75e-09	173	68	7	7e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCell	3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells\|bone_marrow / Manually curated celltypes from each tissue	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 TNFRSF13B IGHV3-74 IGHV3-66	9.48e-09	175	68	7	51301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCell	COPD-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-64D	9.48e-09	175	68	7	d73ee324479172501481b54967a0f3bd870fcf3a
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74	9.86e-09	176	68	7	4b4416f342b732d2cc60133838728880326257d8
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	IGHV3-48 IGHV3-35 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-74	9.86e-09	176	68	7	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72	1.03e-08	177	68	7	c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72	1.03e-08	177	68	7	111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCell	BAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-53 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-66	1.15e-08	180	68	7	6a777a308fa3160d31eda468db930e71862020b2
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-66	1.34e-08	184	68	7	3f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-66	1.34e-08	184	68	7	64bede8db709fd32f40c03265b96f0b12155bb8a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-66	1.34e-08	184	68	7	15f2c10101ccc8ed059520fc082ee42593dff269
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-66	1.34e-08	184	68	7	a90a58d9e319afa1cd572e4c2f516fadc42f56e5
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22	1.39e-08	185	68	7	0fa7970709dc957dea95fabbd83263a0335babd5
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Immature_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV3-48 IGHV3-35 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.73e-08	191	68	7	8c35fccc4617694eae1e55b1107841ffe7f1bac8
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.86e-08	193	68	7	bcda1fb3db7d4c276e3370250a2b79fedd807fc5
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.86e-08	193	68	7	befab58da635723db4f9270d087afa981fc45bf1
ToppCell	Control-B_cell-B_cell\|Control / Disease group,lineage and cell class （2021.01.30）	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.86e-08	193	68	7	d43099c0b8ca68048d6497c4db89d6d5155375f9
ToppCell	BAL-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.86e-08	193	68	7	ba826e6e035e48e1b497af1081c43339b0019e76
ToppCell	Control-Lymphoid-Plasma,_B_cells\|Control / Condition, Lineage and Cell class	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.93e-08	194	68	7	31fff4361ebed6308b1e6b2b705ee6e0a695bd0c
ToppCell	Control-B_cell\|Control / Disease group,lineage and cell class （2021.01.30）	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.93e-08	194	68	7	8388fe4df3461d85b21bd6847a4d32c030aaece4
ToppCell	BAL-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-48 RFTN1 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	1.93e-08	194	68	7	1537e2285d0a8d0a4175dd0b8b1d1ccd887229fc
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-35 IGHV3-23 TNFRSF13B IGHV3-74 IGHV3-66	2.00e-08	195	68	7	2d18f08f33f3b261c77b8adf87d1a184cc6d7400
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-66	2.00e-08	195	68	7	13f4ee21568fd747608412d33559d10561dbb3c8
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-48 IGHV3-23 IGHV3-16 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-66	2.07e-08	196	68	7	c38e7f533c619afe008de0e99042f7180c2da918
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	2.07e-08	196	68	7	e9fe5090452ffdde4bb81b62d57037d823281d00
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	2.07e-08	196	68	7	c2e17f3b2217f20bd7f28a1db4aa7d9a95c52a9c
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	2.14e-08	197	68	7	88b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 CD22 TNFRSF13B	2.14e-08	197	68	7	76465bb2408c7c75f694e8f7cf1a606b796afc3a
ToppCell	Biopsy_Control_(H.)-Immune-Plasma_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	IGHV3-53 IGHV3-23 IGHV3-16 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-66	2.14e-08	197	68	7	275f38ed7e477000e864cecf9b7d49ae134c3b6a
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-53 IGHV3-23 PTPRCAP IGHV3-13 IGHV3-7 CD22 TNFRSF13B	2.22e-08	198	68	7	d51ee880acc5804cd918105fac846a1528333d6c
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-23 PTPRCAP IGHV3-13 CD22 TNFRSF13B IGHV3-72	1.68e-07	160	68	6	7ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-13 CD22 TNFRSF13B	1.81e-07	162	68	6	b46158e260bd2f35702cec73e3b035e8e9ec4469
ToppCell	367C-Lymphocytic-Plasma_cell-\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 IGHV3-72 IGHV3-66	2.16e-07	167	68	6	f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell	367C-Lymphocytic-Plasma_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGHV3-53 IGHV3-48 IGHV3-23 IGHV3-7 IGHV3-72 IGHV3-66	2.16e-07	167	68	6	5e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGHV3-53 IGHV3-7 TROAP IGHV3-74 IGHV3-66 IGHV3-64D	2.16e-07	167	68	6	afb6d0993f3fd44a295874673055189d514f7b11
ToppCell	tumor_Lung-B_lymphocytes-Plasma_cells\|tumor_Lung / Location, Cell class and cell subclass	IGHV3-53 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-73 IGHV3-72	2.32e-07	169	68	6	b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-64D	2.40e-07	170	68	6	ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-64D	2.40e-07	170	68	6	d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-64D	2.40e-07	170	68	6	52787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCell	(2)_Plasma_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-66	3.04e-07	177	68	6	ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-B_cells-Pro-B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGHV3-53 PTPRCAP IGHV3-13 CD22 TNFRSF13B IGHV3-66	3.04e-07	177	68	6	e0035eb725cd412169af1b424119f6422504af93
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	3.15e-07	178	68	6	6f50e2ee66bd9dc12fd3c9ea70e6d50ff76b02e8
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	3.15e-07	178	68	6	b132605f237e766a21042b9a65a564d64c4fec10
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 PTPRCAP IGHV3-7 CD22 TNFRSF13B	3.15e-07	178	68	6	99cd5e517855f1a2d6d75fb2d439751f884862c1
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-23 IGHV3-13 IGHV3-7 TNFRSF13B IGHV3-66	3.36e-07	180	68	6	cea079bc02e08c46600eed05ab9924ec90e1e3d3
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-53 IGHV3-23 TNFRSF13B IGHV3-73 IGHV3-72 IGHV3-66	3.36e-07	180	68	6	e3877f6ef5f54ff689058b4c996ab1851822f871
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-48 IGHV3-23 IGHV3-7 CD22 TNFRSF13B IGHV3-66	3.47e-07	181	68	6	700adfb41e4e377530f0dd31be89e12f109f3469
ToppCell	3'_v3-blood-Lymphocytic_B_plasma\|blood / Manually curated celltypes from each tissue	IGHV3-48 IGHV3-23 IGHV3-7 TROAP TNFRSF13B IGHV3-74	3.70e-07	183	68	6	2477183a290b2c45b6fa091ed76969a3826fe3d9
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-48 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-72 IGHV3-64D	3.70e-07	183	68	6	cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-64D	3.95e-07	185	68	6	0fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-48 IGHV3-23 IGHV3-13 IGHV3-7 IGHV3-74 IGHV3-64D	3.95e-07	185	68	6	79edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGHV3-53 IGHV3-7 TROAP C4A C4B IGHV3-64D	4.07e-07	186	68	6	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	severe_COVID-19-Plasmablast\|World / disease group, cell group and cell class (v2)	IGHV3-7 TROAP TNFRSF13B IGHV3-72 IGHV3-66 IGHV3-64D	4.34e-07	188	68	6	25ca19af4ac419a0f5026a6ccbd8b554b268a6f3
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRCAP CD22 INS KLK8 SIPA1 ITGAL	4.34e-07	188	68	6	13e72b0a2b62d95c805294645fca79d8f96e9e78
ToppCell	3'_v3-bone_marrow-Lymphocytic_B_plasma\|bone_marrow / Manually curated celltypes from each tissue	IGHV3-53 IGHV3-23 IGHV3-7 TNFRSF13B IGHV3-74 IGHV3-72	4.47e-07	189	68	6	dceb011216deb4ffd830144a53c635c05dff5ec5
ToppCell	BAL-Severe-Lymphocyte-B\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGHV3-23 PTPRCAP IGHV3-7 TROAP TNFRSF13B IGHV3-72	4.61e-07	190	68	6	d55b9f9b82bd2b2e1ea2446813fce04f04a1dcdf
Computational	Neighborhood of SERPINI2	PRSS3P2 PRSS1 PRSS3	8.89e-05	25	38	3	GNF2_SERPINI2
Computational	Neighborhood of SPINK1	PRSS3P2 PRSS1 PRSS3	1.12e-04	27	38	3	GNF2_SPINK1
Drug	chlorazanil	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.47e-12	16	57	6	CID000010374
Drug	FFRck	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK3 KLK2	2.15e-12	34	57	7	CID000126484
Drug	CHCl	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK5 KLK3 KLK2	4.18e-12	65	57	8	CID006432229
Drug	S2266	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK3 KLK2	7.36e-12	40	57	7	CID000122333
Drug	T-kinin	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK3 KLK2	8.86e-12	41	57	7	CID000123643
Drug	B3852	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.36e-11	22	57	6	CID003081658
Drug	epanolol	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	3.20e-11	25	57	6	CID000072014
Drug	acetone	KLK15 PRSS1 PRSS3 OXCT1 CD22 KLK8 KLK12 KLK5 KLK3 KLK2	3.39e-11	187	57	10	CID000000180
Drug	camostate	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK5 KLK3 KLK2	5.09e-11	88	57	8	CID000002536
Drug	AC1NRA8H	KLK15 OXCT1 INS KLK8 KLK12 KLK5 KLK3 KLK2	9.50e-11	95	57	8	CID005287756
Drug	N-benzoyl-L-arginine	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK3 KLK2	1.15e-10	58	57	7	CID000097369
Drug	SA446	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.32e-10	31	57	6	CID000071244
Drug	TLCK	KLK15 PRSS1 PRSS3 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.01e-10	158	57	9	CID000004427
Drug	L-lysyl-L-lysyl-L-lysine	KLK15 PRSS1 PRSS3 COL16A1 KLK8 KLK12 KLK5 KLK3 KLK2	2.51e-10	162	57	9	CID000072363
Drug	AC1L1J7E	KLK15 PRTN3 RNH1 INS TNFRSF13B UNC13D C4A KLK3 ITGAL	4.06e-10	171	57	9	CID000004900
Drug	Leupeptin hydrochloride	KLK15 PRSS1 PRSS3 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	1.52e-09	276	57	10	CID000003910
Drug	bumetanide	KLK15 PRSS1 PRSS3 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.39e-09	209	57	9	CID000002471
Drug	benzamidine	KLK15 PRSS1 PRSS3 KLK8 KLK12 BCKDHB KLK3 KLK2	3.15e-09	147	57	8	CID000002332
Drug	EACA	KLK15 PRSS1 PRSS3 KLK8 KLK12 KLK5 KLK3 KLK2	3.90e-09	151	57	8	CID000000564
Drug	L-adrenaline	KLK15 PRSS1 PRSS3 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2 SDS	1.18e-08	446	57	11	CID000000838
Drug	nimesulide	KLK15 CD22 KLK8 KLK12 KLK5 KLK3 KLK2	1.41e-08	114	57	7	CID000004495
Drug	LTC4 (leukotriene C4	KLK15 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	1.55e-08	180	57	8	CID000003907
Drug	phenylmethylsulfonyl fluoride	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	1.77e-08	263	57	9	CID000004784
Drug	kinin 9	KLK15 PRSS1 PRSS3 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	2.08e-08	363	57	10	CID000006026
Drug	atenolol	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.26e-08	122	57	7	CID000002249
Drug	amlodipine	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.82e-08	126	57	7	CID000002162
Drug	CAS 76095-16-4	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.82e-08	126	57	7	CID000003222
Drug	dibutyryl cyclic GMP	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	3.51e-08	130	57	7	CID000036095
Drug	diisopropylfluorophosphate	KLK15 PRSS1 PRSS3 PRTN3 KLK8 KLK12 KLK5 KLK3 KLK2	9.77e-08	321	57	9	CID000005936
Drug	meclofenamate	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	1.29e-07	94	57	6	CID000004036
Drug	theophylline	KLK15 RNH1 INS KLK8 KLK12 KLK5 KLK3 KLK2	1.48e-07	241	57	8	CID000002153
Drug	CP094	PRSS1 PRSS3 KLK8 KLK12 KLK5 KLK3 KLK2	1.80e-07	165	57	7	CID000086322
Drug	amsonine	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	3.38e-07	181	57	7	CID000002866
Drug	AC1LASJR	PRSS1 PRSS3 OXCT1 BCKDHB HADHA	4.04e-07	60	57	5	CID000474231
Drug	angiotensin	KLK15 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	4.90e-07	282	57	8	CID003083715
Drug	H526	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	5.03e-07	192	57	7	CID000002550
Drug	Kki 8	PRSS1 PRSS3 KLK2	5.17e-07	7	57	3	CID000064584
Drug	Kki 7	PRSS1 PRSS3 KLK2	5.17e-07	7	57	3	CID003082667
Drug	Betamethasone-d5	KLK15 PRSS1 PRSS3 COL16A1 INS KLK8 TNFRSF13B KLK12 C4A KLK5 ITGA7 KLK3 ITGAL KLK2 SDS	6.89e-07	1340	57	15	CID000003003
Drug	beta-estradiol 3-benzoate	KLK15 KLK8 KLK12 KLK5 KLK3 KLK2	8.05e-07	128	57	6	CID000003262
Drug	thryroxine	KLK15 RNH1 INS KLK8 KLK12 KLK5 KLK3 KLK2	8.21e-07	302	57	8	CID000000853
Drug	O-methyl-L-serine	PRSS1 PRSS3 SDS	8.26e-07	8	57	3	CID000088250
Drug	lithium aluminum hydride	KLK15 RNH1 INS KLK8 KLK12 KLK5 KLK3 KLK2	1.27e-06	320	57	8	CID000028112
Drug	AC1Q6PCP	KLK15 COL16A1 KLK8 KLK12 KLK5 KLK3 KLK2	1.69e-06	230	57	7	CID000005267
Drug	taurine	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	1.74e-06	231	57	7	CID000001123
Drug	3-mercaptopicolinate	GK2 INS C4A SDS	1.96e-06	36	57	4	CID000119070
Drug	clonidine	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	2.24e-06	240	57	7	CID000002803
Drug	acetylcholine	KLK15 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	3.10e-06	361	57	8	CID000000187
Drug	NSC-648146	PRSS1 PRSS3 PRTN3	3.22e-06	12	57	3	CID000372649
Drug	5-amidinoindole	PRSS1 PRSS3 RNH1	3.22e-06	12	57	3	CID000122670
Drug	4-amidinophenylpyruvic acid	PRSS1 PRSS3 KLK2	3.22e-06	12	57	3	CID000151496
Drug	AC1Q5HK6	KLK15 IGF2R INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	3.96e-06	501	57	9	CID000003640
Drug	furosemide	KLK15 INS KLK8 KLK12 KLK5 KLK3 KLK2	5.10e-06	272	57	7	CID000003440
Drug	LMWH	KLK15 PRSS1 PRSS3 COL16A1 INS KLK8 KLK12 C4A KLK5 KLK2	5.15e-06	663	57	10	CID000000772
Drug	vasopressin	KLK15 OXCT1 INS KLK8 KLK12 KLK5 KLK3 KLK2	5.27e-06	388	57	8	CID011979316
Drug	N-(all-trans-retinoyl)-DL-leucine	RELN C4A	6.16e-06	2	57	2	CID006439237
Drug	retinoylglycine	RELN C4A	6.16e-06	2	57	2	CID005379396
Drug	aldosterone	KLK15 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	6.24e-06	397	57	8	CID000005839
Drug	Cp51	KLK15 KLK3 KLK2	6.63e-06	15	57	3	CID000086345
Drug	Apgpr	PRSS1 PRSS3 INS	6.63e-06	15	57	3	CID003082883
Drug	desogestrel	KLK15 INS KLK8 KLK12 KLK5	6.87e-06	106	57	5	CID000040973
Drug	Hoe 140	KLK15 KLK8 KLK12 KLK3 KLK2	8.23e-06	110	57	5	CID000071362
Drug	sodium chloride	KLK15 PRSS1 PRSS3 IGF2R CD22 INS KLK8 KLK12 KLK5 KLK3 KLK2	8.32e-06	865	57	11	CID000000206
Drug	lauric acid	KLK15 PPP1R10 IGF2R INS BCKDHB HADHA	8.70e-06	193	57	6	CID000003893
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A	KLK15 COL4A2 MICAL1 NKX2-8 COL16A1 ITGA7	9.50e-06	196	57	6	3930_UP
Drug	8-azido-ADP	PRSS1 PRSS3 ABCA4	9.87e-06	17	57	3	CID000121934
Drug	cyclophorine	KLK15 INS KLK8 KLK12 KLK5 KLK3 ITGAL KLK2	1.04e-05	426	57	8	CID000002909
Drug	NSC9700	KLK15 ABCA4 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	1.25e-05	578	57	9	CID000005408
Drug	triflumuron	PRSS1 PRSS3 ANGPTL6 OXCT1	1.26e-05	57	57	4	CID000047445
Drug	AC1LC61J	PRSS1 PRSS3 RNH1 INS	1.45e-05	59	57	4	CID000548548
Drug	Lys-Bradykinin	PRSS1 PRSS3 C4A KLK2	1.55e-05	60	57	4	CID000009569
Drug	N-allylglycine	PRSS1 PRSS3	1.84e-05	3	57	2	CID000076651
Drug	N-acetyl-L-norvaline methyl ester	PRSS1 PRSS3	1.84e-05	3	57	2	CID000150916
Drug	YAKR-CK	PRSS1 PRSS3	1.84e-05	3	57	2	CID005487256
Drug	schizopeptin 791	PRSS1 PRSS3	1.84e-05	3	57	2	CID000636821
Drug	2 alpha-bromoacetoxyprogesterone	PRSS1 PRSS3	1.84e-05	3	57	2	CID000135256
Drug	Lapg-nh2	PRSS1 PRSS3	1.84e-05	3	57	2	CID003082486
Drug	Methotrexate-polylysine	PRSS1 PRSS3	1.84e-05	3	57	2	CID000163214
Drug	methyl octanesulfonate	PRSS1 PRSS3	1.84e-05	3	57	2	CID000165858
Drug	3HFGB	PRSS1 PRSS3	1.84e-05	3	57	2	CID000126268
Drug	4-chlorobenzenediazonium hexafluorophosphate	PRSS1 PRSS3	1.84e-05	3	57	2	CID002723983
Drug	methyl lignocerate	PRSS1 PRSS3	1.84e-05	3	57	2	CID000075546
Drug	10-(carboxyethyl)flavin	PRSS1 PRSS3	1.84e-05	3	57	2	CID003082170
Drug	Z-Lys-CH2Cl	PRSS1 PRSS3	1.84e-05	3	57	2	CID000127335
Drug	2,6-dimethyl-3-pyridinol	PRSS1 PRSS3	1.84e-05	3	57	2	CID000070732
Drug	N-phosphopyridoxyl-L-serine	PRSS1 PRSS3	1.84e-05	3	57	2	CID000195946
Drug	Z-Arg-OH	PRSS1 PRSS3	1.84e-05	3	57	2	CID000071055
Drug	GB-107	PRSS1 PRSS3	1.84e-05	3	57	2	CID000056813
Drug	p-amidinophenylpyruvate	PRSS1 PRSS3	1.84e-05	3	57	2	CID000444106
Drug	v 1194	PRSS1 PRSS3	1.84e-05	3	57	2	CID000074702
Drug	mitorubrinic acid	PRSS1 PRSS3	1.84e-05	3	57	2	CID000379537
Drug	2-aminothiophenol	C4A C4B	1.84e-05	3	57	2	ctd:C005464
Drug	ASA-PE	PRSS1 PRSS3	1.84e-05	3	57	2	CID003037809
Drug	L-TAPA	PRSS1 PRSS3	1.84e-05	3	57	2	CID000193734
Drug	Bvpam	PRSS1 PRSS3 KLK8	1.92e-05	21	57	3	CID000125185
Drug	corilagin	PRSS1 PRSS3 INS C4A	2.13e-05	65	57	4	CID000073568
Drug	NSC98537	KLK15 INS KLK8 KLK12 C4A KLK5 KLK3 KLK2	2.21e-05	473	57	8	CID000005410
Drug	Pro-phe-arg-mca	PRSS1 PRSS3 KLK2	2.21e-05	22	57	3	CID000174085
Drug	dimethyl suberimidate	PRSS1 PRSS3 RNH1 SDS	2.55e-05	68	57	4	CID000034750
Drug	paramethoxyphenyl-acetyl dehydroalanine	RELN ABCA2 C4A BCKDHB	2.70e-05	69	57	4	CID000130300
Disease	fibroblast growth factor 8 isoform A measurement	IGHV3-7 IGHV3-64D	4.93e-06	2	66	2	EFO_0020385
Disease	Autosomal dominant epilepsy with auditory features	MICAL1 RELN	1.48e-05	3	66	2	cv:C1838062
Disease	dynein light chain 1, cytoplasmic measurement	IGHV3-7 IGHV3-64D	1.48e-05	3	66	2	EFO_0020339
Disease	EPILEPSY, FAMILIAL TEMPORAL LOBE, 1	MICAL1 RELN	1.48e-05	3	66	2	600512
Disease	prostate-specific antigen measurement	KLK15 KLK3	1.48e-05	3	66	2	EFO_0020660
Disease	Epilepsy, Familial Temporal Lobe 1	MICAL1 RELN	1.48e-05	3	66	2	C4551957
Disease	Epilepsy, familial temporal lobe, 1	MICAL1 RELN	1.48e-05	3	66	2	cv:C4551957
Disease	complement factor H-like 1 protein measurement	KLK15 FAM220A KLK3	1.60e-05	22	66	3	EFO_0600092
Disease	prostate specific antigen measurement	KLK15 POU5F1B KLK5 KLK3 KLK2	6.49e-05	188	66	5	EFO_0004624
Disease	kallikrein-8 measurement	KLK8 KLK5	7.35e-05	6	66	2	EFO_0020516
Disease	systemic lupus erythematosus (implicated_via_orthology)	TNFRSF13B C4A C4B	1.24e-04	43	66	3	DOID:9074 (implicated_via_orthology)
Disease	disorder of pharynx	CARMIL2 TNFRSF13B ITGAL	1.51e-04	46	66	3	MONDO_0020592
Disease	kallikrein-11 measurement	KLK8 KLK12	1.76e-04	9	66	2	EFO_0010573
Disease	adult onset asthma, body mass index	COL16A1 UNC13D	2.19e-04	10	66	2	EFO_0004340, EFO_1002011
Disease	cancer	KLK15 PRSS1 GAS8 POU5F1B KLK3 KLK2	2.74e-04	400	66	6	MONDO_0004992
Disease	asthma, body mass index	COL16A1 UNC13D	4.41e-04	14	66	2	EFO_0004340, MONDO_0004979
Disease	gestational diabetes (is_marker_for)	ANGPTL6 INS	6.56e-04	17	66	2	DOID:11714 (is_marker_for)
Disease	Lewy Body Disease	IGF2R INS	1.11e-03	22	66	2	C0752347
Disease	Hodgkin Disease	RELN KLHDC8B	1.11e-03	22	66	2	C0019829
Disease	Behcet Syndrome	C4A ITGAL	1.32e-03	24	66	2	C0004943
Disease	Acute Confusional Senile Dementia	RELN IGF2R INS	1.44e-03	99	66	3	C0546126
Disease	Alzheimer's Disease, Focal Onset	RELN IGF2R INS	1.44e-03	99	66	3	C0750900
Disease	Alzheimer Disease, Early Onset	RELN IGF2R INS	1.44e-03	99	66	3	C0750901
Disease	Presenile dementia	RELN IGF2R INS	1.44e-03	99	66	3	C0011265
Disease	Alzheimer Disease, Late Onset	RELN IGF2R INS	1.44e-03	99	66	3	C0494463
Disease	Familial Alzheimer Disease (FAD)	RELN IGF2R INS	1.48e-03	100	66	3	C0276496
Disease	Alzheimer's Disease	RELN IGF2R INS	1.52e-03	101	66	3	C0002395
Disease	multiple myeloma	TNFRSF13B POU5F1 HERC2	2.05e-03	112	66	3	EFO_0001378
Disease	thoracic aortic aneurysm	RFTN1 COL16A1	2.06e-03	30	66	2	EFO_0004282

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVEGLCLAGGGGLAQ	C4B	871	P0C0L5
CLAGGGGLAQQVLVP	C4B	876	P0C0L5
GVRPGECFGLLGVNG	ABCA4	1961	P78363
KGDQGIPGVPGLDNC	COL16A1	976	Q07092
VELLGCGAGPQGEAA	CARMIL2	741	Q6F5E8
GPLGTCLAQVQQAGG	FAM220A	6	Q7Z4H9
GDRQEAIQPGCIGGP	COL4A2	671	P08572
SPGGLLCGVGVEGEA	RFTN1	521	Q14699
LCGVGVEGEAVQNGP	RFTN1	526	Q14699
LQVGQVELGGGPGAG	INS	61	P01308
NTPLCEQGIVGFGIG	BCKDHB	121	P21953
CGPQVGVGLVPQGGL	POU5F1B	76	Q06416
VQLVESGGGLIQPGG	IGHV3-66	21	A0A0C4DH42
VQLVESGGGLVQPGG	IGHV3-72	21	A0A0B4J1Y9
GDSGGPLVCNGVLQG	KLK2	211	P20151
VLVICGPGNNGGDGL	NAXE	111	Q8NCW5
GALEGVPISGCLGDQ	GK3P	246	Q14409
CQGDSGGPLVCGGVL	KLK12	196	Q9UKR0
GGPLVCGGVLQGLVS	KLK12	201	Q9UKR0
GRGGSEGCNIPQNIE	HERC2	3186	O95714
VQLVESGGGLVQPGG	IGHV3-7	21	P01780
VQLVESGGGLVQPGG	IGHV3-13	21	P01766
VQLVESGGGLVQPGG	IGHV3-48	21	P01763
EGDSGGPLVCGGILQ	KLK15	206	Q9H2R5
QELCGALGLEPGGGL	MICAL1	31	Q8TDZ2
VQLVESGGGLVQPGG	IGHV3-64D	21	A0A0J9YX35
GGPVVCNGSLQGLVS	KLK5	246	Q9Y337
VQLVESGGGLVQPGG	IGHV3-74	21	A0A0B4J1X5
VPVLVRDGQPCGGGG	NKX2-8	171	O15522
VQLVDGAVEPQGGGG	PCDH10	676	Q9P2E7
GDSGGPLICDGIIQG	PRTN3	201	P24158
GGPAQEAGLCAGDLI	MAST1	1006	Q9Y2H9
CGPQVGVGLVPQGGL	POU5F1	76	Q01860
IQGGVIGSGCGQLAP	RELN	3286	P78509
NNVCAGLVGGPGLVA	IDH3G	281	P51553
CGPLEGKANGGLVDG	KCNA7	421	Q96RP8
GALEGVPISGCLGDQ	GK2	246	Q14410
GVRPGECFGLLGVNG	ABCA2	2076	Q9BZC7
LERLCPGGAGGQQQV	ANGPTL6	181	Q8NI99
VQLVESGGGLVQPGG	IGHV3-23	21	P01764
PIVAAINGSCLGGGL	HADHA	136	P40939
FQGQQLLCGGVLVGG	KLK8	51	O60259
DSGGPLVCDGALQGI	KLK8	211	O60259
IGGLGNQPCPLGSVE	KLHDC8B	286	Q8IXV7
ELEGGQGPGQKGLCS	ITGA7	926	Q13683
VQLVESGGGLVQPGG	IGHV3-16	21	A0A0C4DH30
SVGGGGLLCGVVQGL	SDS	166	P20132
QGPEGQGGIQVAGLT	KIFC2	551	Q96AC6
CVAENILGTGQRGPG	CD22	396	P20273
PVEGLCLAGGGGLAQ	C4A	871	P0C0L4
CLAGGGGLAQQVLVP	C4A	876	P0C0L4
VQLVETGGGLIQPGG	IGHV3-53	21	P01767
VQLVESGGGLVQPGG	IGHV3-35	21	A0A0C4DH35
VQLVESGGGLVQPGG	IGHV3-73	21	A0A0B4J1V6
VLGGIGCVGQDKGQV	KBTBD12	496	Q3ZCT8
FAVGPEQGGCKDGGV	IGF2R	1841	P11717
GGPVVCNGQLQGIVS	PRSS3P2	201	Q8NHM4
CGQRGPQGRGQGLEE	SYNE4	276	Q8N205
GGLQADPGEGEQQCG	PTPRCAP	121	Q14761
VCELGGEGELGLGGP	SIPA1	166	Q96FS4
RVEAGGGVGPFQACG	SIRT3	21	Q9NTG7
DVPGVLVAGGCAGVL	SLC25A47	216	Q6Q0C1
VGGFGLCGIPENLID	OXCT1	61	P55809
QVGNGVIVGAPGEGN	ITGAL	51	P20701
VGLGQSLCVGIGGDP	SUCLG1	216	P53597
VEGLVGGQCVPLNGG	TROAP	446	Q12815
AGVRELCQGLGQPGS	RNH1	356	P13489
NQVVCVAAGGQPEGG	TACC2	386	O95359
DSGGPVVCNGQLQGV	PRSS3	256	P35030
DSGLGIVCVPAQEGG	TNFRSF13B	276	O14836
GGPVVCNGQLQGVVS	PRSS1	201	P07477
PQGPGGGGINVQEIL	PPP1R10	571	Q96QC0
CLLGIEQGVGVPGGS	UNC13D	136	Q70J99
VIGQTLGQGPAGLVG	GAS8	461	O95995
GDSGGPLVCNGVLQG	KLK3	211	P07288